Trinity

MICHIGAN CANCER RESEARCH CONSORTIUM

DESCRIPTION:THIS AGREEMENT PROVIDES FUNDING UNDER THE INFLATION REDUCTION ACT (IRA) TO TRINITY ALLIANCE OF THE CAPITAL REGION. SPECIFICALLY THE PROJECT WILL SUPPORT CLIMATE RESILIENCY THROUGH TWO COMMUNITY RESILIENCE HUBS, REMEDIATE INDOOR POLLUTANTS IN HOMES, IMPLEMENT RESIDENTIAL ENERGY EFFICIENCY MEASURES, PROVIDE FOR WORKFORCE DEVELOPMENT FOR COMMUNITY RESIDENT CLEAN ENERGY JOBS, SUPPORT WASTE REDUCTION AND A CIRCULAR FOOD ECONOMY THROUGH COMMUNITY COMPOSTING, AND EXPAND GREEN INFRASTRUCTURE THROUGH TREE PLANTING AND EDUCATION. FURTHER, THE GRANT WILL ENABLE MUCH DEEPER COLLABORATION BETWEEN ORGANIZATIONS, HOPING TO REDUCE SILOED APPROACHES TO IMPLEMENTING SOLUTIONS BY SUPPORTING COMMUNITY ENGAGEMENT AND COLLABORATIVE GOVERNANCE. ACTIVITIES:THE ACTIVITIES INCLUDE PROJECT MANAGEMENT, COORDINATION, AND REPORTING; RETROFITTING THE EXISTING AND BUILDING NEW PORTIONS TO THE SOUTHERN RESILIENCE HUB; CONSTRUCTING A NEW NORTHERN RESILIENCE HUB; REMEDIATING SOME HOMES; PROVIDING ENERGY EFFICIENCY UPGRADES FOR OTHER HOMES; PROVIDING AND RECRUITING FOR THE CAPITAL REGION CLEAN ENERGY WORKFORCE DEVELOPMENT PROGRAM; SUPPORTING AND EXPANDING THE COMMUNITY COMPOST INITIATIVE; PLANTING TREES; AND CONDUCTING COMMUNITY ENGAGEMENT AND OUTREACH ACROSS ALL OF THESE ACTIVITIES. SUBRECIPIENT:STATUTORY PARTNER CLEAN+HEALTHY WILL PROVIDE STAFF TO LEAD THE COORDINATION AND COMMUNICATION TO THE PARTNERS, COMMUNITY AND ACROSS THE PROJECT AS A WHOLE. UNDERGROUND RAILROAD EDUCATION CENTER (UREC) WILL CONSTRUCT THE NORTHERN RESILIENCE HUB (AKA UREC RESILIENCE CENTER) AND PROVIDE EMERGENCY RESPONSE PLAN TRAININGS AND RESIDENTIAL EMERGENCY PLAN WORKSHOPS. AFFORDABLE HOUSING PARTNERSHIP WILL PROCESS APPLICATIONS FOR, INSPECT AND REMEDIATE 25 HOMES TO MAKE THEM MOLD, ASBESTOS, RADON OR LEAD SAFE, AND CONDUCT OUTREACH FOR THE PROGRAM. ARBOR HILL DEVELOPMENT CORPORATION WILL INSPECT AND PROVIDE ENERGY-EFFICIENCY RENOVATIONS FOR 33 HOMES AND ADVERTISE AND EDUCATE COMMUNITY MEMBERS ABOUT THE PROGRAM WITH MONTHLY MEETINGS. AVILLAGE WILL EMPLOY ITS INNOVATION BLOCK AMBASSADOR PROGRAM TO PROMOTE, ENGAGE, EDUCATE OR OTHERWISE PROVIDE OUTREACH TO THE COMMUNITY ABOUT THE PROJECT ACTIVITIES. CAPITAL AREA URBAN LEAGUE WILL RECRUIT FOR AND CARRY OUT THE CAPITAL REGION CLEAN ENERGY WORKFORCE DEVELOPMENT PROGRAM. RADIX ECOLOGICAL SUSTAINABILITY CENTER WILL IMPLEMENT THE TREE PLANTING PROGRAM AND ASSOCIATED COMMUNITY ENGAGEMENT AND EDUCATION INCLUDING GENERATING AND SHARING INFORMATION FROM AIR POLLUTION MONITORS, AND RADIX WILL CARRY OUT THE COMMUNITY COMPOST INITIATIVE.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE MONTHLY WORKING GROUP AND QUARTERLY STEERING COMMITTEE MEETINGS FOR PROJECT COORDINATION; 20,907 SQUARE FEET OF RETROFITTED AND 15,593 SQUARE FEET OF NEW SPACE FOR THE SOUTHERN RESILIENCE HUB; 14,000 SQUARE FEET FOR A NEW NORTHERN RESILIENCE HUB; 6 DISASTER PREPAREDNESS TRAININGS PER YEAR FOR EACH HUB; 25 HOMES INSPECTED AND REMEDIATED OF MOLD OR ASBESTOS INCLUDING VERMICULITE, LEAD OR RADON; 33 HOMES TO BE WEATHERIZED AND RECEIVE ENERGY EFFICIENCY UPGRADES; 90 DISADVANTAGED COMMUNITY RESIDENTS PARTICIPATING IN THE CAPITAL REGION CLEAN ENERGY WORKFORCE DEVELOPMENT PROGRAM; COMMUNITY COMPOST INITIATIVE EXPANDED FROM 250 TO 400 RESIDENTS; 200 TREES PLANTED; AND COMMUNITY ENGAGEMENT AND OUTREACH CAMPAIGNS FOR EACH. THE EXPECTED OUTCOMES INCLUDE INCREASED # OF HOUSEHOLDS EDUCATED ON EMERGENCY PREPAREDNESS AS MEASURED BY ATTENDANCE AT PLANNED SESSIONS; INCREASED # OF HOUSEHOLDS WITH ACCESS TO COMMUNITY-WIDE AND INDIVIDUAL HOUSEHOLD EMERGENCY RESPONSE PLANS AND SHELTER AS MEASURED BY NUMBER OF PARTICIPANTS IN SESSIONS; # OF COMMUNITY MEMBERS WITH ACCESS TO EMERGENCY SERVICES AND SAFE SHELTER AS MEASURED BY BUILDING OCCUPANCY LIMITS; INCREASED BUILDING EFFICIENCY AS MEASURED BY ENERGY USAGE BEFORE AND AFTER CONSTRUCTION; % REDUCTION OF FOSSIL-FUEL BASED HOME HEATING/COOLING AND CALCULATED REDUCTION IN ASSOCIATED GREENHOUSE GAS EMISSIONS; REDUCED A

HEALTH CENTER CLUSTER

CARES ACT FUNDING WILL BE USED TO COVER COSTS ASSOCIATED WITH SIGNIFICANT CHANGES TO THE DELIVERY OF INSTRUCTION DUE TO COVID PANDEMIC

SHASTA COLLEGE WILL UTILIZE CARES FUNDS TO ASSIST STUDENTS WITH EMERGENCY FINANCIAL AID ASSISTANCE DUE TO COVID 19

RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN-LICENSED AND TEXAS-EXEMPT AND FLORIDA-DELICENSED ONLY

HEALTH CENTER CLUSTER

TRINITY VALLEY COMMUNITY COLLEGE CARES INSTITUTIONAL GRANT

THE PURPOSE OF THIS PROJECT IS TO REDUCE FUEL BUILDUP IN HIGH WILDFIRE RISK AREAS BY REMOVING ALL LADDER FUELS IN THE AREA AND ANY REMAINING VEGETATION AROUND LARGER TREES LEFT TO SHADE THE UNDERSTORY TO REDUCE REGROWTH.

MICHIGAN CANCER RESEARCH CONSORTIUM CCOP

"ADVANCING DIABETES AWARENESS AND PREVENTION AT TRINITY HEALTH" (ADAPT)

THIS PROJECT SUPPORTS PRIORITY WILDFIRE MITIGATION ACTIONS, SUCH AS ROADSIDE SHADED FUEL BREAKS, DEFENSIBLE SPACE IMPROVEMENTS, AND OTHER STRATEGIC FUEL BREAKS

SHAPE-DP: STRATEGIC HEALTH APPROACH TO PROMOTE EQUITY IN DIABETES PREVENTION - TRINITY HEALTH IS THE FIFTH LARGEST HEALTH SYSTEM IN THE UNITED STATES AND ONE OF THE LARGEST NOT-FOR-PROFIT, CATHOLIC HEALTH CARE SYSTEMS IN THE NATION. IT SERVES PEOPLE AND COMMUNITIES IN 26 STATES WITH 88 HOSPITALS, 135 CONTINUING CARE LOCATIONS, PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE), SENIOR LIVING FACILITIES AND 136 URGENT CARE LOCATIONS. TRINITY HEALTH EMPLOYS 123,000 COLLEAGUES AND NEARLY 27,000 PHYSICIANS AND CLINICIANS CARING FOR DIVERSE POPULATIONS AND COMMUNITIES. WITH AN ANNUAL OPERATING REVENUE OF $21.5 BILLION, THE ORGANIZATION RETURNS $1.4 BILLION ANNUALLY TO COMMUNITIES IN THE FORM OF CHARITY CARE AND OTHER COMMUNITY BENEFIT INITIATIVES. TO DELIVER ON THE ORGANIZATION’S MISSION OF “…BEING A TRANSFORMING, HEALTH PRESENCE IN OUR COMMUNITIES…” IT INCLUDES NATIONAL STRATEGIES TO REDUCE HEALTH INEQUITIES AND DELIVER VALUE-BASED CARE TO VULNERABLE POPULATIONS BY SCREENING AND REFERRING FOR SDOH-RELATED NEEDS AND IMPLEMENTING THE NATIONAL DIABETES PREVENTION PROGRAM (NDPP) TO MANAGE CHRONIC DISEASE BY PREVENTING OR DELAYING THE ONSET OF TYPE 2 DIABETES. USING A MULTI-SECTORAL APPROACH TO REDUCE TYPE 2 DIABETES PREVALENCE AND ADVANCE HEALTH EQUITY IN COMMUNITIES SERVED, TRINITY HEALTH IS APPLYING FOR COMPONENT C OF CDC-RFA-DP-23-0020 TARGETING TRINITY HEALTH’S REGIONAL GEOGRAPHIES IN 16 STATES (CALIFORNIA, CONNECTICUT, DELAWARE, IDAHO, GEORGIA, FLORIDA, IOWA, INDIANA, ILLINOIS, MARYLAND, MASSACHUSETTS. MICHIGAN, NEW YORK, OHIO, OREGON, PENNSYLVANIA) FOCUSING ON THE 4141 MOST POPULOUS CITIES AND THEIR SURROUNDING COMMUNITIES--WHICH INCLUDES OVER 16.5 MILLION PEOPLE OVER THE AGE OF 18. BEGINNING IN YEAR ONE, TRINITY HEALTH WILL LAUNCH SHAPE-DP – STRATEGIC HEALTH APPROACH TO PROMOTE HEALTH EQUITY AND DIABETES PREVENTION. THIS NATIONAL NETWORK OF COLLABORATORS (HUB), INCLUDING TRINITY HEALTH, AETNA/CVS HEALTH, CAPITAL DISTRICT PHYSICIAN’S HEALTH PLAN, COMMUNITY PHARMACY ENHANCED SERVICES NETWORK, YMCA OF THE USA, CATHOLIC CHARITIES USA, HABITNU, AND THE AMERICAN MEDICAL ASSOCIATION AND WILL ADVANCE HEALTH EQUITY AND REDUCE HEALTH DISPARITIES BY IMPLEMENTING A BOLD STRATEGY THAT PROMOTES OPTIMAL HEALTH FOR PEOPLE EXPERIENCING POVERTY AND OTHER VULNERABILITIES, INCLUDING UNMET SDOH RELATED NEEDS, BY BUILDING A NETWORK OF NATIONAL DIABETES PREVENTION PROGRAM (NDPP) PROVIDERS ACROSS THE 16 STATE SERVICE AREA. TOGETHER, THE HUB WILL IMPLEMENT WORKPLAN ACTIVITIES DESIGNED TO SUPPORT THE 4 STRATEGIES FOCUSING ON 3 PRIORITY POPULATIONS INCLUDING ADULTS 65+, AFRICAN AMERICAN/BLACK AND HISPANIC/LATINO. OVER THE COURSE OF THE 5-YEAR PERFORMANCE PERIOD, THE HUB WILL EXPAND MEMBERSHIP TO ENROLL A TOTAL OF 20,000 PARTICIPANTS (14,000 FROM A PRIORITY POPULATION) AND APPLY STRATEGIES TO ENSURE A 60% COMPLETION RATE; ENGAGE 6 COMMERCIAL PAYERS TO COVER THE COSTS OF NDPP PROGRAM DELIVERY THROUGH EXISTING AND NEW PAYMENT MODELS, STANDARDIZE PROCESSES FOR HUB PARTNERS TO SCREEN 100% OF ALL PARTICIPANTS FOR SDOH-RELATED NEEDS, AND REFER 100% OF THOSE WHO REQUEST ASSISTANCE TO A LOW/NO-COST COMMUNITY RESOURCE AND CONTINUALLY WORK TO REMOVE BARRIERS TO PARTICIPATION IN THE NDPP. THROUGH THIS BOLD APPROACH AND STRATEGIC INTERVENTIONS TO ADVANCE HEALTH EQUITY, TRINITY HEALTH EXPECTS TO SEE REDUCED RATES OF TYPE 2 DIABETES INCIDENCE AMONG THE PRIORITY POPULATIONS IN THE SERVICE AREA.

TRINITY VALLEY COMMUNITY COLLEGE CARES EMERGENCY STUDENT GRANT

TRINITY CHURCH, INC. PEACEMAKER FAMILY CENTER PLANBE_ TEEN PREGNANCY PREVENTION PROGRAM (TIER 1B)

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

CARES ACT INSTITUTIONAL RELIEF

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

S202 CAP ADV METRO UNITS

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

UNKNOWN TITLE

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

UNKNOWN TITLE

SUPPORTIVE HOUSING FOR THE ELDERLY

FY10 TEENAGE PREGNANCY PREVENTION: REPLICATION OF EVIDENCE-BASED PROGRAMS (TIER 1)

RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN- PRELICENSED - TRINITY YOUTH SERVICES IS A FEDERALLY FUNDED RESIDENTIAL SHELTER PROGRAM WITHIN THE OFFICE OF REFUGEE RESETTLEMENT (ORR) THAT PROVIDES TEMPORARY CARE AND SERVICES FOR UNACCOMPANIED CHILDREN ARRIVING IN THE UNITED STATES WITHOUT PARENTS OR LEGAL GUARDIANS. THE PROGRAM ENSURES CHILDREN RECEIVE ESSENTIAL SERVICES INCLUDING HOUSING, MEDICAL CARE, EDUCATION, AND MENTAL HEALTH SUPPORT WHILE IDENTIFYING AND VETTING SUITABLE SPONSORS THROUGH COMPREHENSIVE BACKGROUND CHECKS. THE PRIMARY OBJECTIVE IS TO SAFELY REUNITE CHILDREN WITH VETTED SPONSORS IN THE LEAST RESTRICTIVE ENVIRONMENT WHILE MAINTAINING ONGOING CASE MANAGEMENT AND SUPPORT SERVICES.

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

COVID-19 PANDEMIC RELIEF GRANTS FOR STUDENTS

RESIDENTIAL (LONG TERM FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

S202 CAP-ADV ELD MET

IMPACT AID PROGRAM TITLE VIII SECTION 8003

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

TRINITY UNIVERSITY CARES ACT FOR RELIEF OF INSTITUTIONAL EXPENSES DUE TO THE COVID 19 PANDEMIC

COMPETITIVE PERSONAL RESPONSIBILITY EDUCATION PROGRAM

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

TRINITY CHURCH'S PERSONAL RESPONSIBILITY EDUCATION PROGRAM INNOVATIVE STRATEGIES

IMPACT AID PROGRAM TITLE VIII SECTION 8003

TRINITY CHURCH PLANBE_ TEEN PREGNANCY PREVENTION PROJECT

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

THE ROLE OF ADENOSINE IN KETOGENIC DIET THERAPY

TRINITY'S PLANBE_ READY4LIFE PROJECT

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

SAFETY, TRAINING, SITE ASSESSMENTS AND FEASIBILITY STUDIES.

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND FOR TRINITY UNIVERSITY. FUNDS WILL BE MADE AVAILABLE TO STUDENTS IN ACCORDANCE WITH THE ATTACHED CERTIFICATE OF AGREEMENT.

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

TRINITY COLLEGE: CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND (SECOND SUBMISSION)

IMPACT AID PROGRAM TITLE VIII SECTION 8003

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND, 50% INSTITUTIONAL ALLOCATION

IMPACT AID PROGRAM TITLE VIII SECTION 8003

CASA-TRINITY CERTIFIED COMMUNITY BEHAVIORAL HEALTH CENTER (CCBHC) OF THE SOUTHERN TIER NY - CASA-TRINITY WILL CREATE A CERTIFIED COMMUNITY BEHAVIORAL HEALTH CLINIC (CCBHC) THAT SERVES RESIDENTS OF THE HIGH NEED COUNTIES OF STEUBEN, CHEMUNG, LIVINGSTON AND TIOGA IN RURAL NY STATE IN NORTHERN APPALACHIA. IN THE FIRST YEAR, THE PROJECT WILL SERVE 5,500 PERSONS WHO HAVE SERIOUS MENTAL ILLNESS (SMI) OR SUBSTANCE USE DISORDERS (SUD), INCLUDING OPIOID USE DISORDERS; CHILDREN AND ADOLESCENTS WITH SERIOUS EMOTIONAL DISTURBANCE (SED); AND INDIVIDUALS WITH CO-OCCURRING MENTAL AND SUBSTANCE DISORDERS (COD). AN ADDITIONAL 1,350 INDIVIDUALS WILL BE SERVED IN THE SECOND YEAR OF THE PROJECT. THIS CCBHC WILL PROVIDE COMPREHENSIVE 24/7 ACCESS TO COMMUNITY-BASED MENTAL AND SUBSTANCE USE DISORDER SERVICES; TREATMENT OF CO-OCCURRING DISORDERS; AND PHYSICAL HEALTHCARE IN ONE SINGLE LOCATION, WITH LOCATIONS PLANNED THROUGHOUT THE REGION. TELEHEALTH WILL BE USED WHEN APPROPRIATE TO LIMIT TRAVEL, AND TREATMENT WILL BE PROVIDED IN A HOLISTIC, PATIENT-CENTERED MANNER. PARTNERSHIPS WITH COUNTY DEPARTMENTS OF COMMUNITY SERVICES, OTHER SUBJECT MATTER EXPERTS AND PRIMARY CARE PROVIDERS AS DESIGNATED COLLABORATING ORGANIZATIONS (DCOS) WILL BUILD CAPACITY FOR ADDRESSING THESE DISORDERS THROUGHOUT THE REGION.

IMPACT AID PROGRAM TITLE VIII SECTION 8003 AND SECTION 8007(A)

INSTITUTIONAL PORTION OF HEERF/CARES ACT

TRINITY COLLEGE: CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

WATER & SEWER LINES

WILDLAND CRISIS STRATEGY FOR COMMUNITY RISK REDUCTION STEWARDSHIP PROJECT

THE SHASTA-TEHAMA-TRINITY JOINT COMMUNITY COLLEGE DISTRICT SERVES A VAST SUBURBAN AND RURAL AREA WITH A HIGH PERCENTAGE OF PELL GRANT RECIPIENTS. FUNDS WILL BE USED TO SUPPORT STUDENTS

PREDOMINANTLY BLACK INSTITUTIONS PROGRAM - FORMULA GRANTS

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND, 50% DIRECT-TO-STUDENT ALLOCATION

FUNDS TO BE USED FOR SUPPORTING RELATED TRINITY INTERNATIONAL UNIVERSITY ENTITIES AFFECTED BY COVID-19.

GAINING EARLY AWARENESS AND READINESS FOR UNDERGRADUATE PROGRAMS (GEAR-UP) - GEAR-UP

CS 10K: MOBILE CSP: USING MOBILE LEARNING TO TEACH CS PRINCIPLES IN CONNECTICUT SCHOOLS

TRINITY UNIVERSITY UPWARD BOUND

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

ANE - NURSE PRACTITIONER RESIDENCY PROGRAM

DEVELOPMENT OF IMMUNOLOGICAL REAGENTS FOR THE IDENTIFICATION OF NEW WORLD MONKEY BIOMARKERS - PROJECT SUMMARY MARMOSETS, SQUIRREL MONKEYS, AND OWL MONKEYS ARE NEW WORLD MONKEYS (NWM) STUDIED EXTENSIVELY IN A BROAD ARRAY OF RESEARCH AREAS, INCLUDING INFECTION, VISION, AUDITION, SOCIAL BEHAVIOR, COGNITION, NEURODEGENERATIVE DISEASES, REPRODUCTION, AND GENETIC MANIPULATION. ONE CRITICAL SHORTCOMING OF THE NWM ANIMAL MODELS IS THE LIMITED NUMBER OF IMMUNOLOGICAL REAGENTS THAT ARE CURRENTLY AVAILABLE DUE TO MORE THAN 33 MILLION OF YEARS OF EVOLUTIONARY DIVERGENCE. THIS SCARCITY OF RESEARCH TOOLS REDUCES THE TRANSLATIONAL VALUE OF THESE NONHUMAN PRIMATES. THE GOAL OF THIS R24 APPLICATION IS TO REMEDY THIS DEFICIENCY BY GENERATING ANTIBODIES AND VALIDATING IMMUNOLOGICAL ASSAYS THAT IDENTIFY IMPORTANT NWM BIOMARKERS OF INFLAMMATION AND METABOLISM, FOR WHICH THERE IS CURRENTLY LACK OF REAGENTS. INFLAMMATION IS A COMMON PROCESS INVOLVED IN AGING, OBESITY, AND PATHOLOGIES SUCH AS INFECTIOUS DISEASES, MULTIPLE SCLEROSIS, AND AGE-RELATED NEURODEGENERATIVE DISORDERS, ALL OF WHICH ARE BEING MODELED IN THESE SPECIES. THE NWM INFLAMMATORY BIOMARKERS TO BE PRODUCED INCLUDE C-REACTIVE PROTEIN (CRP), INTERLEUKIN-4 (IL-4), IL-6, IL-10, INTERFERON GAMMA-INDUCIBLE PROTEIN 10 (CXCL10, IP-10), GRANZYME B, AND THE SURFACE GLYCOPROTEIN CD69. GASTROINTESTINAL HORMONES TO BE PRODUCED, CRITICAL FOR VALIDATION OF STUDIES OF METABOLIC SYNDROME, INCLUDE INSULIN, ADIPONECTIN, AND LEPTIN. IN ORDER TO ACCOMPLISH OUR GOAL, WE HAVE ASSEMBLED A TEAM OF SCIENTISTS FROM ACADEMIC AND RESEARCH INSTITUTIONS AND A BIOTECHNOLOGY COMPANY SPECIALIZED IN THE PRODUCTION OF REAGENTS OF VETERINARY AND HUMAN USE. WE WILL PRODUCE NWM PROTEINS IN EUKARYOTIC CELLS, AND USE THE RECOMBINANT MARMOSET PROTEINS TO PRODUCE MONOCLONAL ANTIBODIES (MMABS) IN MICE (SPECIFIC AIM 1). WE WILL THEN USE THE MARMOSET RECOMBINANT PROTEINS TO IDENTIFY EPITOPE SPECIFICITY OF THESE MABS, SELECT THE ONES THAT ALSO RECOGNIZE SQUIRREL MONKEY AND OWL MONKEY HOMOLOGUES, AND IDENTIFY OPTIMAL ANTIBODY PAIRS FOR TECHNIQUES SUCH AS ELISA, ELISPOT, LUMINEX, AND INTRACELLULAR CYTOKINE STAINING (ICS) ASSAYS (SA 2). FINALLY, THESE IMMUNOLOGICAL ASSAYS WILL BE VALIDATED WITH SAMPLES OBTAINED FROM PLASMA ALIQUOTS FROM NWM EXPOSED TO TRANSIENT METABOLIC AND INFLAMMATORY CHALLENGES, AND FROM EX VIVO STIMULATED NWM CELLS (SA 3). AT THE END OF THIS PROJECT, RESEARCHERS WORKING IN DIFFERENT NWM MODELS OF HUMAN DISEASE WILL HAVE ACCESS TO RESEARCH TOOLS FOR IMPROVED VALIDATION OF THEIR PRECLINICAL MODELS. A RESOURCE WEBSITE WILL BE DEVELOPED TO DISSEMINATE THE AVAILABILITY OF REAGENTS, TO TRACK THE IMPACT OF THESE REAGENTS IN BIOMEDICAL STUDIES, AND TO DISTRIBUTE PROTOCOLS AND SOPS. DEVELOPMENT OF THESE REAGENTS IS OF TRANS-NIH INTEREST, WILL INCREASE THE TRANSLATIONAL VALUE OF MARMOSET, SQUIRREL MONKEY AND OWL MONKEY MODLES, AND WILL EXPAND THE SCIENTIFIC DATA OBTAINED FROM THESE ANIMALS.

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

THE SHASTA-TEHAMA-TRINITY JOINT COMMUNITY COLLEGE DISTRICT IS APPLYING UNDER ABSOLUTE PRIORITY 4 FOR SUPPLEMENTAL HEERF FUNDING

UPWARD BOUND

EXPANDING EDUCATIONAL OPPORTUNITY THROUGH COLLABORATIVE COMMUNITY-BASED PARTNERSHIP

SHASTA COLLEGE WILL PROVIDE TUTORING, FINANCIAL AID ASSISTANCE AND EDUCATION, COUNSELING,TRANSFER ASSISTANCE, AND CAREER PLANNING SERVICES TO LOW INCOME, FIRST GENERATION, AND STUDENTS WITH DISABILITY

HEALTHY MARRIAGE DEMONSTRATION, PRIORITY AREA 8

SHASTA COLLEGE, IN FAR NORTHERN CALIFORNIA, WILL PROVIDE TUTORING, ACADEMIC GUIDANCE, FINANCIAL AID ASSISTANCE, AND A 6 WEEK SUMMER PROGRAM TO 65 STUDENTS FROM TWO HIGH NEED TARGET HIGH SCHOOLS.

STUDENT SUPPORT SERVICES PROGRAM

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM-IMPACT - THE OPIOID EPIDEMIC IN NY STATE IS UNFORTUNATELY ACCELERATING AT A FASTER RATE THAN IN MOST STATES IN THE NATION, AND MUCH OF WESTERN NY HAS THE HIGHEST RATES OF OPIOID OVERDOSES AND DEATHS IN NY STATE OVERALL. CASA-TRINITY’S WESTERN NY RURAL ALLIANCE: COMMUNITIES THAT HEAL (WNYRA:CTH) INITIATIVE WILL ADDRESS THE CRITICAL OPIOID EPIDEMIC IN SIX COUNTIES IN WESTERN NY: ALLEGANY, CATTARAUGUS, CHAUTAUQUA, LIVINGSTON STEUBEN AND WYOMING. WITH TECHNICAL ASSISTANCE AND EXPERTISE FROM COLUMBIA UNIVERSITY IN THE EVIDENCE-BASED COMMUNITIES THAT HEAL (CTH) AND OPIOID-OVERDOSE REDUCTION CONTINUUM OF CARE APPROACH (ORCAA), WNYRA:CTH, A COALITION OF NINE CORE PARTNERS AND MULTITUDES OF OTHER PARTNERS WILL INVOLVE THE ENTIRE COMMUNITY IN ADDRESSING OPIOID USE DISORDER (OUD), INCLUDING ADDING CRITICALLY NEEDED MEDICATIONS FOR OPIOID USE DISORDER (MOUD) SERVICES IN TWO COUNTIES, ADDING TWO RECOVERY CENTERS AND EXPANDING THE SERVICES OF A THIRD RECOVERY CENTER TO INCLUDE EMPLOYMENT SERVICES, AND ADDING A TOTAL OF FIVE CERTIFIED RECOVERY PEER ADVOCATES (CRPA- PEERS) TO BETTER CONNECT PERSONS WITH OUD, WITH SPECIAL FOCUS ON THE JUSTICE-INVOLVED POPULATION, CHILDREN AND ADOLESCENTS, PREGNANT WOMEN, RURAL FARMERS, PERSONS WITH DISABILITIES AND THE SENECA NATION OF INDIANS. PEERS ARE PEOPLE WITH LIVED-EXPERIENCE WITH SUD/OUD AND ARE BEST ABLE TO ENGAGE AND SUPPORT PERSONS WITH OUD IN THEIR LONG-TERM RECOVERY AND ASSIST THEM IN ACCESSING ANY SUPPORTS THEY MAY NEED TO OVERCOME OBSTACLES TO THEIR RECOVERY. A PEER AFFILIATED WITH THE HOSPITAL IN CHAUTAUQUA COUNTY WILL DIRECTLY CONNECT PERSONS WITH OUD WITH NEEDED SERVICES. AS A RESULT OF THESE ADDITIONAL SERVICES, OVER 4,500 PEOPLE (UNDUPLICATED) WILL RECEIVE NEEDED SERVICE FOR OUD OVER FOUR YEARS, INCLUDING OVER 2,300 RECEIVING TREATMENT SERVICES AND OVER 2,200 BENEFITTING FROM RECOVERY SERVICES, WITH HALF OF EACH NUMBER LIKELY TO ACCESS BOTH SERVICES. IN ADDITION TO VASTLY EXPANDING THE AVAILABILITY OF TREATMENT AN D RECOVERY SERVICES FOR PEOPLE WITH OUD, THE PROJECT INVOLVES INNOVATIVE APPROACHES TO REACH THE MOST RURAL OF THE RURAL POPULATIONS, INCLUDING ENGAGING AND SUPPORTING INFORMAL COMMUNITY LEADERS TO REDUCE THE STIGMA ASSOCIATED WITH OUD, AND DISCREETLY BUT DIRECTLY CONNECTING RURAL FARMERS AND OTHERS TO OUD SERVICES. AN INNOVATIVE CONNECTION WITH 211 (NATIONWIDE INFORMATION AND REFERRAL SERVICE) ON A SUD-SPECIFIC TEXTING PROGRAM WILL ALSO HELP TO CONNECT PEOPLE TO SERVICES. THE PROJECT ALSO INCLUDES DEVELOPING BETTER LINKAGES WITH SCHOOLS, JAILS AND PRENATAL PROVIDERS TO BETTER CONNECT THE POPULATIONS THESE GROUPS SERVE TO TREATMENT. XYLAZINE AND FENTANYL-ADULTERATED DRUGS ARE EMERGING THREATS, AND TEST STRIPS FOR THESE WILL BE DISTRIBUTED SO THAT PEOPLE USING DRUGS CAN TEST THEIR SUPPLY AND REDUCE THE LIKELIHOOD OF OVERDOSE AND DEATH. METHODS ARE INCLUDED TO IMPROVE AND SUSTAIN THE WORKFORCE, PROMOTING FROM WITHIN AND GROWING OUR OWN TO ADDRESS SHORTAGES OF A QUALIFIED WORKFORCE, EMBEDDING NEW SKILLS AND ABILITIES THROUGH TRAINING, AND HELPING TO ENSURE THAT FUTURE HEALTH PROFESSIONALS SUCH AS PHYSICIAN ASSISTANT STUDENTS UNDERSTAND SUD/OUD ISSUES AND HOW THEY ARE AN INTEGRAL PART OF EACH PERSON’S OVERALL HEALTH. ALL TREATMENT AND RECOVERY SERVICES BEING DEVELOPED ARE EXPECTED TO BE SUSTAINABLE AFTER GRANT FUNDING ENDS. THE WNYRA:CTH WILL ALSO DEVELOP A CONTINUITY OF OPERATIONS PLAN FOR THE REGION TO SUSTAIN LONG-TERM RECOVERY.

NOYCE TEACHING FELLOWS AT TRINITY UNIVERSITY

UPWARD BOUND PROGRAM

HEALTHY MARRIAGE DEMONSTRATION, PRIORITY AREA 7

SHASTA COLLEGE IS A COMMUNITY COLLEGE LOCATED IN FAR NORTHERN CALIFORNIA. OUR TRIO ETS WILL SERVE 500 STUDENTS WITH TUTORING, MENTORING,COUNSELING, ENROLLMENT AND FINANCIAL AID ASSISTANCE AND TRANSFER

TO ASSIST THE THREE COUNTY CONSORTIUM IMPROVE THE NUMBER OF MENTAL HEALTH PROFESSIONALS IN EACH COMMUNITY BY HAVING THE GRANT ASSIST IN THE TRAINING/EDUCATION OF EACH MENTAL HEALTH PROFESSIONAL HIRED.

STUDENT SUPPORT SERVICES PROGRAM

MARMOSETS AS A MODEL FOR UNDERSTANDING SOCIAL, NEUROENDOCRINE, AND VASCULAR CONTRIBUTIONS TO COGNITIVE AGING

PROGRAM FOR SURVIVORS OF TORTURE (PSOT)

TRINITY CHURCH'S PLANBE_ HARLEM SEXUAL RISK AVOIDANCE EDUCATION PROGRAM

TO COVER COSTS ASSOCIATED WITH SIGNIFICANT CHANGES TO THE DELIVERY OF INSTRUCTION AND THE DISRUPTION OF CAMPUS OPERATIONS DUE TO CORONAVIRUS.

HEALTH CENTER CLUSTER

TALENT SEARCH PROGRAM

HIGHER EDUCATION EMERGENCY RELIEF FOR MINORITY SERVING INSTITUTION

UPWARD BOUND PROGRAM

SHASTA COLLEGE IS A NORTHERN CALIFORNIA COMMUNITY COLLEGE, THAT WILL SERVE TRIO UB ELIGIBLE STUDENTS FROM ENTERPRISE, CENTRAL VALLEY, AND GATEWAY TO COLLEGE HIGH SCHOOLS

SHASTA COLLEGE IS PROPOSING PACT (PROMISE FOR ACCESS, COMPLETION AND TRANSFER)TO BUILD INSTITUTIONAL RESILIENCE THROUGH TECHNOLOGY & EXPAND DUAL ENROLLMENT IN RURAL OPPORTUNITY ZONE HIGH SCHOOLS

TRIO - STUDENT SUPPORT SERVICES - STUDENT SUPPORT SERVICES PROGRAM

UPWARD BOUND

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

METABOLIC THERAPY TO RELIEVE PAIN: KETOGENIC DIET AND ADENOSINE

TRINITY UNIVERSITY MCNAIR SCHOLARS PROGRAM

SHASTA COLLEGE IS A COMMUNITY COLLEGE LOCATED IN FAR NORTHERN CALIFORNIA. OUR TRIO UB WILL SERVE 60 LOW INCOME AND/OR FIRST GENERATION CORNING HIGH SCHOOL STUDENTS WITH EVIDENCE-BASED SUPPORT SERVICES

TRINITY CHURCH, INC. PEACEMAKERS FAMILY CENTER SEXUAL RISK AVOIDANCE EDUCATION PROGRAM

TRINITY CHURCH COMMUNITY BASED ABSTINENCE EDUCATION PROJECT

NEUROINFLAMMATORY AND COGNITIVE CONSEQUENCES OF LOSING CHOLINERGIC ANTI-INFLAMMATORY TONE IN THE FOREBRAIN

UPWARD BOUND PROGRAM

TALENT SEARCH PROGRAM

TRIO - STUDENT SUPPORT SERVICES - STUDENT SUPPORT SERVICES PROGRAM

PROVIDE EMERGENCY FINANCIAL AID GRANTS TO STUDENTS FOR EXPENSES RELATED TO THE DISRUPTION OF CAMPUS OPERATIONS DUE TO CORONAVIRUS.

MCNAIR SCHOLARS PROGRAM AT TRINITY UNIVERSITY

RONALD E. MCNAIR POSTBACCALAUREATE ACHIEVEMENT

TRINITY CHURCH READY4LIFE PROJECT - TRINITY CHURCH WILL IMPLEMENT THE READY4LIFE PROGRAM TO HELP HIGH SCHOOL YOUTH IN GRADES 9-12 AND HIGH SCHOOL-AGED YOUTH (14-17) IN MIAMI-DADE COUNTY BUILD HEALTHY RELATIONSHIP SKILLS WHILE SUPPORTING POSITIVE SOCIOEMOTIONAL DEVELOPMENT AND PROMOTING SUCCESSFUL TRANSITIONS TO YOUNG ADULTHOOD. THE PROJECT WILL DELIVER A 17.5-HOUR PRIMARY WORKSHOP USING EVIDENCE-BASED RELATIONSHIP SMARTS PLUS CURRICULUM, MIND MATTERS RESILIENCE EDUCATION, AND NEXT GEN PERSONAL FINANCE LESSONS TO 2,250 YOUTH OVER FIVE YEARS, WITH 1,800 COMPLETING AT LEAST 90% OF WORKSHOPS. TRINITY WILL ALSO PROVIDE SUPPLEMENTAL CAREER SUCCESS SEQUENCE WORKSHOPS TO HELP YOUTH TRANSITION TO ADULTHOOD BY STRENGTHENING THEIR CAPACITY TO CONTINUE EDUCATION, BEGIN CAREERS, AND ESTABLISH HEALTHY RELATIONSHIPS, WHILE SERVING PRIORITY ZIP CODES WITH HIGH RATES OF POVERTY, UNEMPLOYMENT, AND FAMILY INSTABILITY.

MULTIFAMILY HOUSING SERVICE COORDINATORS

RONALD E. MCNAIR POST-BACCALAUREATE ACHIEVEMENT

PREDOMINANTLY BLACK INSTITUTIONS PROGRAM - FORMULA GRANTS

TRINITY MIAMI SEXUAL RISK AVOIDANCE EDUCATION PROGRAM

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

RAIL AND TRANSIT SECURITY GRANT PROGRAM

SEE NOTICE OF AWARD, ATTACHMENT 1 - TERMS AND CONDITIONS, ATTACHMENT D, STATEMENT OF WORK, ABSTRACT.

THE CAPITAL REGION GERIATRIC CENTER WILL: EXPAND THE SAFETY NET FOR THOSE LIVING ALONE WITH ADRD, COLLABORATE WITH THOSE OFFERING SERVICES TO THE DEVELOPMENTALLY DISABLED, AND WORK WITH CAREGIVERS.

RURAL COMMUNITIES OPIOID RESPONSE-IMPLEMENTATION

TALENT SEARCH PROGRAM

UBM INSTITUTIONAL: INTEGRATED RESEARCH IN BIOMATHEMATICS AT TRINITY UNIVERSITY

TRINITY CHURCH SEXUAL RISK AVOIDANCE EDUCATION PROJECT

SRSLY DRUG FREE COMMUNITIES SUPPORT PROGRAM

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

CONTINUUM OF CARE PROGRAM

RURAL HEALTH OUTREACH SPECIAL INITIATIVE

ALS RISK IN LATIN AMERICANS- A POPULATION BASED CASE CONTROL COMPARATIVE STUDY WITH 3 EUROPEAN POPULATION BASED COHORTS.

TRINITY CHURCH'S PLANBE_ NYC SEXUAL RISK AVOIDANCE EDUCATION PROGRAM

QUAD CITIES BE HEALTHY QC

6/7 PSYCHIATRIC GENOMICS CONSORTIUM: ADVANCING DISCOVERY AND IMPACT - PROJECT SUMMARY NOW IN ITS 13TH YEAR, THE PSYCHIATRIC GENOMICS CONSORTIUM IS PERHAPS THE MOST INNOVATIVE AND PRODUCTIVE EXPERIMENT IN THE HISTORY OF PSYCHIATRY. THE PGC UNIFIED THE FIELD AND ATTRACTED A CADRE OF OUTSTANDING SCIENTISTS (802 INVESTIGATORS FROM 157 INSTITUTIONS IN 41 COUNTRIES). PGC WORK HAS LED TO IDENTIFICATION OF ~500 GENETIC LOCI IN THE 11 PSYCHIATRIC DISORDERS WE STUDY. OUR WORK HAS LED TO 320 PAPERS, MANY IN HIGH-PROFILE JOURNALS (NATURE 3, CELL 5, SCIENCE 2, NAT GENET 27, NAT NEUROSCI 9, MOL PSYCH 37, BIOL PSYCH 25). AS SUMMARY STATISTICS ARE FREELY AVAILABLE, PSYCHIATRIC DISORDERS OFTEN FEATURE PROMINENTLY IN PAPERS BY NON-PGC INVESTIGATORS. TO ADVANCE DISCOVERY AND IMPACT, WE PROPOSE TO CONTINUE THE WORK OF THE PGC ACROSS 11 DISORDER GROUPS. CONSIDERABLE NEW DATA ARE COMING IN THE NEXT FIVE YEARS. WE THUS CAN RAPIDLY AND EFFICIENTLY INCREASE OUR KNOWLEDGE OF THE FUNDAMENTAL BASIS OF MAJOR PSYCHIATRIC DISORDERS. AIM 1: WE WILL CONTINUE TO ADVANCE GENETIC DISCOVERY FOR SEVERE PSYCHIATRIC DISORDERS IN ALL WORKING GROUPS, SYSTEMATICALLY INTERFACE WITH LARGE BIOBANK STUDIES TO ENSURE MAXIMAL COMPARABILITY, AND AGGRESSIVELY PROMOTE NEW STUDIES OF INDIVIDUALS WITH PSYCHIATRIC DISORDERS FROM DIVERSE ANCESTRIES TO INCREASE DISCOVERY AND IMPROVE FINE-MAPPING. AIM 2: MOST STUDIES ANALYZE COMMON VARIATION (AIM 1), RARE CNV (AIM 2), AND RARE EXOME/GENOME RESEQUENCING RESULTS (VIA COLLABORATION) IN ISOLATION: WE WILL APPLY AN INTEGRATIVE FRAMEWORK TO RIGOROUSLY EVALUATE THE CONTRIBUTIONS OF ALL MEASURED TYPES OF GENETIC VARIATION ON RISK FOR PSYCHIATRIC DISORDERS. AIM 3: WE WILL MOVE BEYOND CLASSICAL CASE-CONTROL DEFINITIONS TO A MORE BIOLOGICALLY-BASED AND NUANCED UNDERSTANDING BY ENABLING LARGE TRANS-DIAGNOSTIC STUDIES, CONVENE TRANS-DISCIPLINARY TEAMS TO USE GENETICS TO ADDRESS UNRESOLVED QUESTIONS ABOUT THE NATURE OF PSYCHIATRIC DISORDERS, AND TO PROMOTE LARGE STUDIES OF THE SEVEREST CASES SEEN IN PSYCHIATRIC PRACTICE (LEVERAGING THE GLOBAL REACH OF PGC INVESTIGATORS). AIM 4: WE WILL WORK TO MAXIMIZE THE IMPACT OF OUR WORK VIA TRANSLATIONAL EFFORTS: CLOSE COLLABORATIONS WITH NEUROSCIENCE CONSORTIA TO UNDERSTAND THE BIOLOGICAL IMPLICATIONS OF OUR FINDINGS; WORK TO IDENTIFY MODIFIABLE CAUSAL RISK FACTORS; AND WORK TO ROBUSTLY PREDICT CLINICAL OUTCOMES AND IDENTIFY PATIENT SUBSETS. AIM 5: WE WILL INCREASE IMPACT OF OUR WORK BY EXTENDING AND FORMALIZING OUTREACH TO DIFFERENT COMMUNITIES (INCLUDING PHARMA AND BIOTECH), VIA DIGITAL MEDIA (TWITTER, FACEBOOK, WIKIPEDIA), AND BY DEVELOPING, DISTRIBUTING, AND UPDATING RESOURCES/EDUCATIONAL MATERIAL FOR PATIENTS, FAMILIES, AND MEDICAL PROFESSIONALS. WE WILL CONVENE A SCIENTIFIC ADVISORY BOARD TO ENSURE WE RESPOND POSITIVELY TO THOSE INVESTED IN OUR RESULTS SUCCESSFUL COMPLETION OF THIS BODY OF WORK WILL GREATLY ADVANCE KNOWLEDGE OF THE GENETIC BASIS OF PSYCHIATRIC DISORDERS WITH POTENTIALLY MAJOR NOSOLOGICAL AND TREATMENT IMPLICATIONS. THESE GOALS ARE CONSISTENT WITH A CORE MISSION OF THE NIMH, AND THE CENTRAL IDEA OF THE PGC: TO CONVERT THE FAMILY HISTORY RISK FACTOR INTO BIOLOGICALLY, CLINICALLY, AND THERAPEUTICALLY MEANINGFUL INSIGHTS.

CARES ACT HIGHER EDUCATION INSTITUTIONAL FUNDING

15.904 HISTORIC PRESERVATION FUND GRANTS-IN-AID AACR PRESERVATION SAM.GOV HISTORIC PRESERVATION FUND GRANTS-IN-AID ASSIST IN THE IDENTIFICATION, EVALUATION, AND PROTECTION OF HISTORIC PROPERTIES BY SUCH MEANS AS EDUCATION, SURVEY, PLANNING, TECHNICAL ASSISTANCE, PRESERVATION, DOCUMENTATION, AND FINANCIAL INCENTIVES LIKE GRANTS AND TAX CREDITS AVAILABLE FOR HISTORIC PROPERTIES. OPPORTUNITY P22AS00648 AFRICAN AMERICAN CIVIL RIGHTS (AACR) IS A COMPETITIVE PHYSICAL PRESERVATION GRANT PROGRAM TO DOCUMENT, INTERPRET, AND PRESERVE THE SITES AND STORIES OF THE FULL HISTORY OF THE AFRICAN AMERICAN STRUGGLE TO GAIN EQUAL RIGHTS AS CITIZENS FROM THE TRANSATLANTIC SLAVE TRADE FORWARD. PROJECTS ARE FOR HISTORIC SITES LISTED IN, OR ELIGIBLE FOR LISTING IN THE NATIONAL REGISTER, AND INCLUDE ARCHITECTURAL SERVICES, HISTORIC STRUCTURE REPORTS, PRESERVATION PLANS, AND PHYSICAL PRESERVATION TO STRUCTURES. BENEFICIARIES INCLUDE STATES, TRIBES, LOCAL GOVERNMENTS, AND NONPROFITS. THIS PROJECT IS AWARDED TO THE NON-PROFIT TRINITY UNITED METHODIST CHURCH FOR WINDOW REPAIRS, BRICK REPOINTING, ROOF IMPROVEMENTS, AND TO ADDRESS WATER DAMAGE AND SAFETY ISSUES OF THE HISTORIC SITE OF TRINITY UNITED METHODIST CHURCH IN ORANGEBURG, SC.

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

REDUCING CHILD FATALITIES AND RECURRING INJURIES

COLD ENGRAMS AT THE INTERFACE OF MEMORY AND METABOLISM

LIPID PHOSPHATASES AS DYNAMIC REGULATORS OF PROTEIN CONFORMATION

RENOVATION OF CHEMISTRY RESEARCH LABORATORIES AT TRINITY COLLEGE

ONE SIDE WELDING SYSTEM

PROGRAM FOR SURVIVORS OF TORTURE (PST)

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND- IHES (CFDA: 84:425F)

HEALTH CARE AND OTHER FACILITIES

TRINITY RIVER WATERSHED RESTORATION

PUBLIC OUTREACH AND EDUCATION

HIGHER EDUCATION EMERGENCY RELIEF FUND INSTITUTIONAL PORTION

THE HCTC COALITION OF LIVINGSTON CITY

MRI: ACQUISITION OF HIGH PERFORMANCE SCIENTIFIC COMPUTING CLUSTER AT TRINITY UNIVERSITY

MULTIFAMILY HOUSING SERVICE COORDINATORS

CARES ACT HIGHER EDUCATION STUDENT EMERGENCY FUNDING

SOLAR STILL RESEARCH AND EXPANDED DEMONSTRATION PROJECT FOR INTEGRATED ONFARM DRAINAGE MANAGEMENT PR

CAMPUS ADVOCACY, RESOURCES, AND EDUCATION FOR SAFETY PROJECT (CARES)

COLLABORATIVE RESEARCH: RUI: REGULATING THE TRIBOLIUM SEGMENTATION CLOCK

FINANCIAL AID FOR SCIENCE AND TECHNOLOGY STUDENTS ENHANCED WITH RESEARCH

FINANCIAL AID FOR SCIENCE AND TECHNOLOGY STUDENTS

INNATE MEMORY - THE PLASTICITY OF INSTINCT

ROBERT NOYCE SCHOLARSHIPS AT TRINITY UNIVERSITY

CAREER: SYNTHETIC CO-HOSTS FOR SEQUENCE-SPECIFIC RECOGNITION AND LABELING OF PEPTIDES IN AQUEOUS SOLUTION

RURAL HEALTH CLINIC VACCINE CONFIDENCE PROGRAM

EFFECTS OF A KETOGENIC DIET ON REGIONAL BRAIN ENERGY AND PLASTICITY

1. AWARD PURPOSE:THIS AGREEMENT COVERS TRINITY COUNTY PARTICIPATION IN ACTIVITIES UNDER THE AUTHORITY OF SECTION 3406(B)(1) THAT RECTIFY THE PHYSICAL IMPACTS SUSTAINED BY OPERATION OF THE TRD. IMPACTS INCLUDE CHANGES IN THE PHYSICAL HABITAT IN THE TRINITY RIVER THAT AFFECT THE HEALTH AND WELL-BEING OF THE PUBLIC BY AFFECTING DOMESTIC WATER SOURCES, SEPTIC SYSTEMS, AND OTHER PHYSICAL INFRASTRUCTURE. ASSIST IN RESTORING THE RIVER AND SURROUNDING HABITATS IN ORDER TO PROTECT LOCAL FISH AND OTHER SPECIES.2. ACTIVITIES TO BE PERFORMED: PRIMARY EMPHASIS WILL BE ON TMC PARTICIPATION, FEMA EFFORTS AND ON TECHNICAL ASSISTANCE FROM TRINITY COUNTY DEPARTMENT OF TRANSPORTATION AND PLANNING DEPARTMENT. FUNDING AVAILABLE THROUGH THIS COOPERATIVE AGREEMENT WILL ENSURE THAT TRINITY COUNTY EMPLOYEES ARE SUPPORTED FINANCIALLY WHEN WORKING ON ALL ASPECTS OF TRRP PROJECT IMPLEMENTATION INCLUDING BUT NOT LIMITED TO: 1) PARTICIPATION IN MEETINGS AND COLLABORATION THROUGH PROJECT SITE PLANNING AND DESIGN PROCESS, 2) DEPARTMENT OF TRANSPORTATION ON-SITE TECHNICAL ASSISTANCE AND IMPLEMENTATION SUPPORT ACTIVITIES, 3) COORDINATION AND PRODUCTION OF ENVIRONMENTAL DOCUMENTATION AS NEEDED (E.G., NEPA/CEQA DOCUMENTS, FEMA COORDINATION FOR FLOODPLAIN DEVELOPMENT, AND PROJECT PERMIT APPROVAL), 4) TRINITY MANAGEMENT COUNCIL (TMC) PARTICIPATION; 5) IDENTIFICATION AND PLANNING ASSISTANCE FOR CRITICAL INFRASTRUCTURE NEEDS IN RELATION TO TRINITY RIVER FLOWS; 6) REALTY ACTIONS IN THE FORM OF RIGHTS-OF-ENTRY, RIGHT-OF-WAY, AND FLOW EASEMENTS.3.PROJECTED DELIVERABLES OR OUTCOMES:OVERALL THIS COOPERATIVE AGREEMENT IS MEANT TO SUPPORT COORDINATION BETWEEN RECLAMATION'S TRRP AND THE TRINITY COUNTY SO THAT LEGAL GUIDELINES MAY BE EFFICIENTLY MET. THE COOPERATIVE AGREEMENT IS INTENDED TO ENSURE THAT TRRP PROJECTS ALONG THE TRINITY RIVER CORRIDOR MAY EFFICIENTLY USE TRINITY COUNTY STAFF AND RESOURCES TO MAXIMIZE THE EFFECTIVENESS OF TRRP PROJECTS IN IMPLEMENTING THE RECORD OF DECISION.4. INTENDED BENEFICIARIES:THE PURPOSE OF THE TRINITY MANAGEMENT COUNCIL IS TO PROVIDE OVERALL GUIDANCE AND DIRECTION TO THE TRINITY RIVER RESTORATION PROGRAM IN ORDER TO RESTORE, ENHANCE, AND CONSERVE NATURAL PRODUCTION OF ANADROMOUS FISHERIES, NATIVE PLANT COMMUNITIES, AND ASSOCIATED WILDLIFE RESOURCES TO THE TRINITY RIVER BASIN IN SUFFICIENT QUANTITY AND QUALITY TO ENSURE LONG-TERM SUSTAINABILITY. 5.SUBRECIPIENT ACTIVITIES (IF KNOWN OR SPECIFIED AT TIME OF AWARD): N/A

6/7 PSYCHIATRIC GENOMICS CONSORTIUM FINDING ACTIONABLE VARIATION

RISK AND PROTECTIVE FACTORS FOR PSYCHOSOCIAL RESILIENCE IN SPOUSAL CAREGIVERS FOR SPOUSES WITH COGNITIVE DECLINE - ABSTRACT FAMILY CARING PLAYS AN ESSENTIAL ROLE IN SUSTAINING HEALTH SYSTEMS, BUT CAN PLACE SOCIAL, FINANCIAL, PHYSICAL, AND EMOTIONAL DEMANDS ON CARERS. UNDERSTANDING WHAT CAREGIVERS NEED TO SUPPORT THEM IS KEY TO FACILITATING FAMILY CARE. SPOUSAL CARERS FOR SPOUSES WITH ALZHEIMER’S AND ALZHEIMER’S-RELATED DEMENTIA (AD/ADRD) ARE PARTICULARLY SUBJECT TO ADDITIONAL STRESS AND BURDEN. WHY SOME CARERS SEEM TO MANAGE THEIR LONG-TERM WELL-BEING BETTER THAN OTHERS IS LESS UNDERSTOOD. DIFFERENCES IN WELL-BEING OBSERVED BETWEEN CAREGIVERS MAY BE AN INDICATOR OF HOW THEY DIFFER IN ADAPTING TO CHANGING CIRCUMSTANCES AND THEIR ABILITY TO MAINTAIN OR RECOVER THEIR MENTAL HEALTH AND WELL-BEING FOLLOWING AN ADVERSE EVENT (PSYCHOSOCIAL RESILIENCE). THIS STUDY LEVERAGES DATA FROM INTERNATIONAL HARMONIZED COGNITIVE ASSESSMENT PROTOCOL (HCAP) STUDIES AND LONGITUDINAL DATA FROM THE HEALTH AND RETIREMENT STUDY (HRS) FRAMEWORK OF BIENNIAL AGING COHORT STUDIES. THE HRS (15 WAVES), THE IRISH LONGITUDINAL STUDY ON AGEING (TILDA) (6 WAVES), THE ENGLISH LONGITUDINAL STUDY OF AGEING (ELSA) (9 WAVES) AND THE SURVEY OF HEALTH, AGEING AND RETIREMENT IN EUROPE (SHARE) (8 WAVES) ARE LARGE, NATIONALLY REPRESENTATIVE, PROSPECTIVE COHORT STUDIES THAT EXAMINE THE SOCIAL, ECONOMIC AND HEALTH CIRCUMSTANCES OF COMMUNITY-DWELLING ADULTS AGED ≥50 YEARS FROM WHICH SPOUSAL CARER- DYADS CAN BE DRAWN. COGNITIVE ASSESSMENTS ARE AVAILABLE FROM HCAP AND DETAILED MEASUREMENTS OF WELL- BEING AND MENTAL HEALTH AND COGNITION FROM THE INDIVIDUAL LONGITUDINAL COHORT STUDIES (INCLUDING MEASURES OF DEPRESSIVE SYMPTOMS, QUALITY OF LIFE AND LIFE SATISFACTION), IN ADDITION TO WELL-CHARACTERIZED SOCIAL, ECONOMIC AND HEALTH DATA, FORMAL CARE PROVISION, AND POLICY CONTEXT. THIS STUDY AIMS TO: (1) IDENTIFY CHANGES OVER TIME IN PSYCHOSOCIAL RESILIENCE IN MENTAL HEALTH AND WELL-BEING, AND COGNITIVE HEALTH IN SPOUSAL CAREGIVERS FOR SPOUSES WITH NORMAL COGNITION/AD/ARD; (2) DETERMINE THE RISK AND PROTECTIVE FACTORS ASSOCIATED WITH RESILIENT GROUPS AND INVESTIGATE WHAT ROLE SOCIETAL AND POLICY CONTEXTS PLAY IN SHAPING THESE TRAJECTORIES; (3) INVESTIGATE HOW THE NEEDS OF BOTH THE CAREGIVER AND THE CARE RECIPIENT INFLUENCE PSYCHOSOCIAL RESILIENCE. TO ADDRESS THESE AIMS, MULTIPLE WAVES OF HRS FRAMEWORK SURVEY DATA COMBINED WITH HCAP DATA WILL BE INVESTIGATED AND ADVANCED LONGITUDINAL STATISTICAL TECHNIQUES (GROWTH MIXTURE MODELS, MULTILEVEL ANALYSIS AND ACTOR-PARTNER INTERDEPENDENCE MODELS) WILL BE APPLIED. GIVEN THE COMPLEX NATURE OF THIS STUDY, WE HAVE ASSEMBLED AN OUTSTANDING MULTI-DISCIPLINARY TEAM OF CLINICAL AND ACADEMIC RESEARCHERS WITH EXPERTISE IN EACH OF THE CONSTITUENT PARTS OF THE PROJECT. STUDY RESULTS WILL IDENTIFY IMPORTANT RISK AND PROTECTIVE FACTORS FOR PSYCHOSOCIAL RESILIENCE IN CARER-DYADS THAT ARE AMENABLE TO INTERVENTION. IN DOING SO, THE STUDY WILL INFORM THE PRIORITIES FOR SOCIAL AND COMMUNITY-LEVEL SERVICES AND SUPPORTS FOR SPOUSAL CAREGIVERS TO ENHANCE RESILIENCE AND MAINTAIN COGNITION IN BOTH CAREGIVERS AND THEIR SPOUSES, AS WELL AS AID IN THE DESIGN OF NEW POLICIES AND PROGRAMS TO MEET THESE NEEDS.

SHASTA COLLEGE WILL UTILIZE CARES HERRF FUNDS TO ASSIST STUDENTS WITH EMERGENCY FINANCIAL AID AND COVER COSTS ASSOCIATED WITH SIGNIFICANT CHANGES TO THE DELIVERY OF INSTRUCTION DUE TO COVID-19

RURAL HEALTH CARE SERVICES OUTREACH GRANT PROGRAM

SHASTA/SIMPSON CARES

RIGHT PLACE, RIGHT TIME: INFORMATION DESIGN TO SUPPORT DECISIONS IN ACUTE CARE

CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND

COLLABORATIVE RESEARCH: RUI: STRUCTURE-FUNCTION RELATIONSHIPS AND EFFICIENCY OF BACTERIAL FLAGELLAR MOTORS USING COMPUTATIONAL FLUID DYNAMICS AND DIRECTED EVOLUTION EXPERIMENTS -BACTERIA ARE AMONG THE OLDEST ORGANISMS ON EARTH. THROUGH BIOLOGICAL EVOLUTION, MANY BACTERIA HAVE ACQUIRED A BIOMECHANICAL FLAGELLUM CONSISTING OF A HELICAL APPENDAGE THAT IS ROTATED BY A MOLECULAR MOTOR TO MOVE THEM THROUGH THEIR FLUID ENVIRONMENT. FLAGELLAR GENETIC ORGANIZATION, REGULATION, AND STRUCTURE ARE BROADLY CONSERVED ACROSS BACTERIAL SPECIES, AND FLAGELLA PLAY VITAL ROLES IN THE BACTERIAL LIFE CYCLE, INCLUDING IN HOST-MICROBE INTERACTIONS. THUS, UNDERSTANDING BACTERIAL MOTILITY HAS BROAD IMPLICATIONS IN MEDICINE, IN BIOLOGY, AND IN THE DEVELOPMENT OF MICRO-ROBOTIC SWIMMERS. THIS RESEARCH AIMS TO UNDERSTAND HOW THE ENERGY EFFICIENCY OF THE BACTERIAL MOTOR HAS INFLUENCED THE EVOLUTIONARY DEVELOPMENT OF THE BACTERIAL MOTILITY SYSTEM. THE PROJECT WILL CREATE PRECISELY CALIBRATED COMPUTATIONAL TOOLS TO STUDY VARIANTS OF THE MEDICALLY IMPORTANT ORGANISM PSEUDOMONAS AERUGINOSA WITH DIFFERENT MOTOR PROPERTIES. THE ENERGY EFFICIENCY OF EACH VARIANT WILL BE MEASURED AND ASSOCIATED WITH STRUCTURAL CHANGES IN MOTOR COMPONENTS. THE COMPUTATIONAL TOOLS AND A LIBRARY OF THESE MOTOR VARIANTS WILL BE MADE PUBLICLY AVAILABLE SO THAT OTHER RESEARCHERS MAY USE THEM FOR RELATED RESEARCH. THE EXPERIMENTS AND COMPUTATIONS REQUIRED FOR THIS WORK WILL ALL BE CONDUCTED IN TANDEM WITH UNDERGRADUATE STUDENTS, WITH THE GOAL THAT MANY OF THEM, INCLUDING STUDENTS FROM UNDERREPRESENTED BACKGROUNDS, WILL PURSUE CAREERS IN INTERDISCIPLINARY SCIENTIFIC RESEARCH. RECENT WORK HAS UNCOVERED THE MOLECULAR STRUCTURE OF THE STATOR UNIT RESPONSIBLE FOR GENERATING TORQUE IN THE BACTERIAL FLAGELLAR MOTOR. THIS PROJECT AIMS TO CHARACTERIZE THE RELATIONSHIPS BETWEEN SPECIFIC STRUCTURAL PROPERTIES OF THE BACTERIAL STATOR AND ITS ENERGY EFFICIENCY. STRAINS OF P. AERUGINOSA WITH SUBOPTIMAL STATORS WILL BE CREATED AND USED IN DIRECTED EVOLUTION EXPERIMENTS TO SELECT FOR VARIANT STRAINS WITH IMPROVED MOTILITY. QUANTITATIVE MICROSCOPY WILL BE USED TO MEASURE BACTERIAL MOTION AS THEY MOVE THROUGH DIFFERENT FLUID ENVIRONMENTS. EXPERIMENTALLY DETERMINED TRAJECTORIES WILL BE INPUT INTO PRECISELY CALIBRATED COMPUTATIONAL FLUID DYNAMICS SIMULATIONS TO DETERMINE THE ENERGY EFFICIENCY OF THE STATOR. THE DETERMINATION OF SEQUENCE AND STRUCTURAL FEATURES OF EVOLVED STATORS WITH DIFFERENT ENERGY EFFICIENCIES WILL PROVIDE INSIGHTS INTO THE RELATIONSHIP BETWEEN THE MECHANICAL PROPERTIES AND BIOMOLECULAR STRUCTURES OF NANOMOTORS. ADDITIONALLY, TO STUDY HOW THE PRESENCE OF A NEARBY BOUNDARY AFFECTS THE SWIMMING EFFICIENCY OF THE EVOLVED STRAINS, MOTILITY EXPERIMENTS WILL BE PERFORMED NEAR SMOOTH SURFACES AND SURFACES WITH TUNABLE VISCOSITY AND ELECTROSTATIC PROPERTIES. THE SURFACES WILL BE CONSTRUCTED FROM LIPIDS AND PROTEINS TO MIMIC THE ENVIRONMENTS THAT P. AERUGINOSA COMMONLY ENCOUNTERS IN ITS NATURAL ENVIRONMENT AS IT UNDERGOES MOTILE-TO-SESSILE TRANSITIONS. THE CALIBRATION MEASUREMENTS WILL ALLOW OTHER RESEARCHERS TO CREATE ADDITIONAL PRECISELY CALIBRATED COMPUTATIONAL FLUID DYNAMICS MODELS AND DEVELOP SIMILAR COMPUTATIONAL PROBES AS USED IN THIS PROJECT. THE PUBLICLY AVAILABLE LIBRARY OF EVOLVED MOTOR VARIANTS AND THE STRUCTURE-FUNCTION MAP FOR THE STATOR WILL DEEPEN THE UNDERSTANDING OF THE RELATIONSHIP BETWEEN MOTOR PROTEINS AND MOTOR PERFORMANCE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

FUNCTIONALIZED RECEPTORS FOR EFFICIENT EPITOPE RECOGNITION - PROJECT SUMMARY BIOMEDICAL SCIENCE RELIES HEAVILY ON METHODS FOR ATTACHING LIGAND BINDING SITES TO PROTEINS. SUCH EPITOPE TAGS ARE IMPORTANT FOR PROTEIN AFFINITY PURIFICATION, FOR IMPROVING PROTEIN SOLUBILITY, AND FOR ADDING FUNCTIONALITY TO PROTEINS SUCH AS FLUORESCENT LABELS OR SITES FOR CHEMICAL MODIFICATION. THE PROPOSED RESEARCH AIMS TO DEVELOP SYNTHETIC RECEPTORS THAT TARGET PROTEINS ENGINEERED WITH EFFICIENT EPITOPES COMPRISING ONLY 2-3 AMINO ACID RESIDUES. THE EPITOPES ARE BOUND SITE-SELECTIVELY AND WITH SUBNANOMOLAR AFFINITY BY SMALL (1-2 KDA) MONOFUNCTIONAL SYNTHETIC RECEPTORS WITH ADDED ABILITY TO BIND, FLUORESCE, OR ATTACH TO SOLID SUPPORTS. THE RECEPTORS ARE STABLE AND FUNCTIONAL IN PHYSIOLOGICAL CONDITIONS, INCLUDING SERUM, AND PROTEINS BOUND TO THESE RECEPTORS CAN BE RELEASED ON DEMAND UPON THE ADDITION OF SMALL MOLECULE COMPETITORS. THE PROPOSED AIMS WILL: 1) FURTHER OPTIMIZE THE EPITOPES; 2) INSTALL THE EPITOPES INTO RECOMBINANT PROTEINS AND HUMAN INSULIN; AND 3) DEVELOP MONOFUNCTIONAL DERIVATIVES OF THE SYNTHETIC RECEPTOR TO ENHANCE BINDING AND TO ENABLE AFFINITY PURIFICATION AND PROTEIN SENSING. THE PROPOSED EPITOPES WILL ADD FUNCTION TO TARGET PROTEINS WHILE HAVING MINIMAL IMPACT ON STRUCTURE AND ACTIVITY. THE PROPOSED WORK BUILDS ON THE RULES FOR SEQUENCE-SELECTIVE RECOGNITION OF PEPTIDES AND PROTEINS BY CUCURBIT[N]URILS ESTABLISHED IN THE UNDERGRADUATE RESEARCH LAB OF THE PI. MANY RESEARCH GROUPS HAVE DEVELOPED APPLICATIONS BUILT ON THESE RULES, AND WE ANTICIPATE THAT THE PROPOSED RESEARCH WILL ESTABLISH A CORE COMPETENCY THAT SHOULD FACILITATE EXISTING BIOMEDICAL APPLICATIONS AND INSPIRE NEW ONES.

IMPROVE EXISTING AIRPORT I

SMALL HEALTH CARE PROVIDER QUALITY IMPROVEMENT

PREVENTING PRESCRIPTION STIMULANT DIVERSION AND MEDICATION MISUSE VIA A WEB-BASED SIMULATION INTERVENTION

RUI: BEHAVIORAL CONVERGENCE IN CARIBBEAN LIZARDS: MORPHOLOGICAL AND PHYSIOLOGICAL MECHANISMS

MINIMAL PROTEIN AFFINITY TAGS - PROJECT SUMMARY BIOMEDICAL SCIENCE RELIES HEAVILY ON METHODS FOR ATTACHING LIGAND BINDING SITES TO PROTEINS. SUCH AFFINITY TAGS ARE ESSENTIAL FOR PROTEIN AFFINITY PURIFICATION, FOR IMPROVING PROTEIN SOLUBILITY, AND FOR ADDING FUNCTIONALITY TO PROTEINS SUCH AS FLUORESCENT LABELS OR SITES FOR CHEMICAL MODIFICATION. THE PROPOSED RESEARCH AIMS TO DEVELOP A GENERAL METHOD FOR MODIFYING TARGET PROTEINS USING AFFINITY TAGS THAT COMPRISE ONLY 1-2 AMINO ACID RESIDUES. THE MINIMAL AFFINITY TAGS ARE BOUND SITE-SPECIFICALLY AND WITH HIGH-AFFINITY BY SMALL (1-2 KDA) SYNTHETIC RECEPTOR THAT CAN BE CONJUGATED TO SOLID SUPPORTS AND SMALL MOLECULES. THE RECEPTORS ARE STABLE AND FUNCTIONAL IN PHYSIOLOGIC CONDITIONS, INCLUDING SERUM, AND PROTEINS BOUND TO THESE RECEPTORS CAN BE RELEASED EASILY UPON THE ADDITION OF SMALL MOLECULE COMPETITORS. THE PROPOSED AIMS INCLUDE: 1) FURTHER OPTIMIZING DIPEPTIDE RECOGNITION SITES; 2) INVESTIGATING THE BINDING OF SYNTHETIC RECEPTORS TO TARGET SITES THAT ALREADY EXIST IN PROTEIN PHARMACEUTICALS AND OTHER BIOACTIVE PEPTIDES AND PROTEINS; 3) INSTALLING MINIMAL AFFINITY TAGS INTO RECOMBINANT PROTEINS AND PROTEIN PHARMACEUTICALS; AND 4) DEVELOPING FUNCTIONAL DERIVATIVES OF THE SYNTHETIC RECEPTOR TO BRING FUNCTIONALITY TO THE TARGET PROTEINS. SUCH MINIMAL AFFINITY TAGS WILL ADD SUBSTANTIAL FUNCTION TO TARGET PROTEINS WHILE HAVING MINIMAL IMPACT ON THEIR STRUCTURE AND ACTIVITY. THE PROPOSED WORK BUILDS ON THE RULES FOR SELECTIVE, HIGH-AFFINITY RECOGNITION OF PEPTIDES AND PROTEINS BY CUCURBIT[N]URILS ESTABLISHED IN THE UNDERGRADUATE RESEARCH LAB OF THE PI. MANY RESEARCH GROUPS HAVE DEVELOPED APPLICATIONS BUILT ON THESE RULES, AND WE ANTICIPATE THAT THE PROPOSED RESEARCH WILL ESTABLISH A CORE COMPETENCY THAT SHOULD FACILITATE EXISTING BIOMEDICAL APPLICATIONS AND INSPIRE NEW ONES.

FUNDING FOR HIGHER EDUCATION STUDENTS WHO HAVE BEEN DEALING WITH COVID-19 RELATED ISSUES.

ARRA - CAPITAL IMPROVEMENT PROGRAM

SAVE AMERICAS TREASURES GRANTS FROM THE HISTORIC PRESERVATION FUND PROVIDE PRESERVATION AND OR CONSERVATION ASSISTANCE TO NATIONALLY SIGNIFICANT HISTORIC PROPERTIES AND COLLECTIONS. GRANTS REQUIRE A DOLLAR-FOR-DOLLAR, NON-FEDERAL MATCH, WHICH CAN BE CASH OR DOCUMENTED IN-KIND. THE GRANT PROGRAM IS ADMINISTERED BY THE NATIONAL PARK SERVICE (NPS) IN PARTNERSHIP WITH THE NATIONAL ENDOWMENT FOR THE ARTS (NEA), THE NATIONAL ENDOWMENT FOR THE HUMANITIES (NEH), AND THE INSTITUTE OF MUSEUM AND LIBRARY SERVICES (IMLS). BENEFICIARIES INCLUDE STATES, TRIBES, LOCAL GOVERNMENTS, AND NONPROFITS.THIS PHYSICAL PRESERVATION PROJECT IS AWARDED TO THE NONPROFIT, TRINITY REPERTORY COMPANY, VIA CONGRESSIONALLY DIRECTED SPENDING FOR REPAIRS TO THE FACADE OF THE LEDERER THEATER.

2020 HPF AACR - TRINITY UNITED METHDST CHURCH, PRESERVATION AND REPAIR OF HISTORIC TRINITY UNITED METHODIST CHURCH: PHASE III

2018 HPF AACR - TRINITY UNITED METHODIST CHURCH

2017 HPF AACR - TRINITY UNITED METHODIST CHURCH

NORTHERN CALIFORNIA SAWMILLS LOG FLARE REDUCER INSTALLATIONS

TRINITY COUNTY ADULT DRUG TREATMENT COURT.

PRISON RE-ENTRY INITIATIVE

SUPPORT THE HEALTHY COMMUNITIES THAT CARE COALITION OF LIVINGSTON COUNTY

2007 COMMUNITY PARTNERSHIPS TO ELIMINATE HEALTH DISPARITIES

MRI-R2: ACQUISITION OF A 500 MHZ NMR SPECTROMETER BY TRINITY UNIVERSITY

IMPROVE EXISTING AIRPORT I

CPATH-2: COLLABORATIVE RESEARCH: BUILDING A COMMUNITY TO INCORPORATE HUMANITARIAN FREE AND OPEN SOURCE SOFTWARE INTO UNDERGRADUATE COMPUTING EDUCATIO

COLLABORATIVE RESEARCH: RUI: ADDING SEGMENTS ONE BY ONE: A COMPARATIVE ANALYSIS OF THE GROWTH ZONE IN ARTHROPODS

RUI: PHYSIOLOGICAL REGULATION OF ATP AND ADENOSINE: LINKING METABOLISM TO NEURONAL EXCITABILITY

HANDS-ON-TRAINING, TECHNICAL ASSISTANCE AND OUTREACH FOR HISORICALLY UNDERSERVED FARMERS AND RANCHERS IN NORTH CENTRAL MISSISSIPPI.

ICOB:COLLABORATIVE RESEARCH:RUI: GENERATING COMPLEXITY: INTEGRATING EXPERIMENTAL AND COMPUTER MODELING APPROACHES TO LINK GENES AND CELL BEHAVIOR IN

METALLOPEPTIDE BASED MIMICS OF MONONUCLEAR NONHEME IRON ENZYMES: UNDERSTANDING ENZYMATIC REACTIVITY USING DESIGNED METALLOPEPTIDES - PROJECT ABSTRACT. MONONUCLEAR NONHEME IRON (MNHFE) ENZYMES PERFORM AN ARRAY OF CHEMICALLY DIVERSE REACTIONS THAT ARE VITAL TO MANY DIFFERENT ASPECTS OF HUMAN HEALTH INCLUDING: ANTIBIOTIC BIOSYNTHESIS, PRODUCTION OF KEY METABOLITES, AND DNA REPAIR. THUS, THE MISREGULATION AND DYSFUNCTION OF MNHFE ENZYMES HAVE BEEN IMPLICATED IN A NUMBER OF DISORDERS INCLUDING NEURODEGENERATION, CANCERS, DIABETES, AND CARDIOVASCULAR DISEASES. A LARGE CLASS OF MNHFE ENZYMES CONTAINS A REDUCED FE(II) ION THAT ACTIVATES DIOXYGEN, FORMING A HIGHLY REACTIVE FEIII-O2– SPECIES. ONCE FORMED, THIS FEIII-O2– INTERMEDIATE CAN PROMOTE A LARGE NUMBER OF DIFFERENT REACTIONS LEADING TO AN ENORMOUS DIVERSITY IN CHEMICAL REACTIVITY. DESPITE THE SURPRISING SIMILARITIES IN ACTIVE-SITE (AND SOMETIMES SUBSTRATE) STRUCTURES, EACH ENZYME PROMOTES A HIGHLY SPECIFIC REACTION AND YIELDS A HIGHLY SPECIFIC PRODUCT. THE FACTORS LEADING TO SUCH HIGH REACTION SPECIFICITY FROM THESE SIMILAR ACTIVE-SITE STRUCTURES ARE NOT FULLY UNDERSTOOD. THE OVERARCHING GOAL OF THE WORK PROPOSED HEREIN IS TO UNDERSTAND HOW THE FEIII-O2– INTERMEDIATE IN TWO MNHFE ENZYMES, CYSTEINE DIOXYGENASE (CDO) AND ISOPENICILLIN-N-SYNTHASE (IPNS), CAN SELECTIVELY PROMOTE TWO VASTLY DIFFERENT REACTIONS ON STRUCTURALLY SIMILAR SUBSTRATES: SULFUR OXYGENATION (CDO) VS C-H ATOM ABSTRACTION (IPNS). BOTH CDO AND IPNS MODIFY A THIOL-CONTAINING SUBSTRATE ONCE IT IS COORDINATED TO THE IRON-CENTER. WE HYPOTHESIZE THAT THE DIFFERENTIAL REACTIVITY IN THESE TWO ENZYMES IS PROMOTED BY THE ORIENTATION OF THE NOMINAL S(3P)-TYPE ORBITAL OF THE COORDINATED SUBSTRATE, WHICH WILL TURN ON OR OFF A THERMODYNAMICALLY FAVORED S-BASED OXYGENATION REACTION. TO EXPLORE THIS HYPOTHESIS, WE WILL PREPARE A LIBRARY OF STRUCTURALLY RELATED METALLOPEPTIDES THAT WILL PROMOTE EITHER CDO- OR IPNS-LIKE CHEMISTRIES. THE MAJOR DIFFERENCE BETWEEN THESE PEPTIDES WILL BE THE ORIENTATION OF THE S(3P)-TYPE ORBITAL RELATIVE TO THE VECTOR OF ATTACK OF THE SUPEROXO LIGAND OF THE FEIII-O2– INTERMEDIATE. BECAUSE THE GEOMETRIC AND ELECTRONIC STRUCTURES OF THESE PEPTIDES WILL ALL BE NEARLY IDENTICAL, ALL DIFFERENCES IN REACTIVITY WILL BE ATTRIBUTABLE TO THE S(3P) ORBITAL ORIENTATION. THIS RESEARCH MAKES USE OF A LARGE NUMBER OF TOOLS ENCOUNTERED IN BIOINORGANIC CHEMISTRY, THUS PROVIDING AN EXCELLENT TRAINING PLATFORM FOR UNDERGRADUATE RESEARCHERS. IN ADDITION TO BIOMIMIETIC METALLOPEPTIDE DESIGN AND SYNTHESIS, THESE SYSTEMS WILL BE SUBJECTED TO MECHANISTIC, SPECTROSCOPIC (ELECTRONIC ABSORPTION, EPR, (M)CD, X-RAY ABSORPTION, VIBRATIONAL AND MÖSSBAUER SPECTROSCOPIES), AND HIGH-LEVEL COMPUTATIONAL STUDIES. THE USE OF METALLOENZYME MIMICS IN OUR INVESTIGATIONS IS ESPECIALLY NOTEWORTHY; FEW STUDIES HAVE BEEN PERFORMED WHERE INSIGHT INTO SPECIFIC BIOCHEMICAL PROCESSES ARE REVEALED THROUGH METALLOPEPTIDE BASED METALLOENZYME MIMICS. THEREFORE, COMPLETION OF THIS PROJECT WILL NOT ONLY REVEAL INTERESTING ASPECTS OF MNHFE BIOCHEMISTRY, BUT WILL ALSO EXPAND THE LIMITS OF INVESTIGATIONS CONCERNING METALLOPEPTIDE BASED METALLOENZYME MIMICS.

PUBLIC CHARTER SCHOOLS

MACROSTRUCTURAL AND MICROSTRUCTURAL ANALYSIS OF THE PRIMATE CORPUS CALLOSUM

AFFORDABLE CARE ACT (ACA) GRANTS FOR SCHOOL-BASED HEALTH CENTERS CAPITAL PROGRAM

FUNDING WILL BE USED TO COVER THE INSTITUTIONS EXPENSES RELATED TO THE DISRUPTION OF CAMPUS OPERATIONS DUE TO CORONAVIRUS.

TRINITY SCHOOL FOR MINISTRY SEEKS MUCH-NEEDED FIPSE GRANT ASSISTANCE AS PART OF THE CARES ACT TO ACCOMPANY THE PREVIOUS STUDENT RELIEF GRANT AWARDED TO OUR PRIVATE INSTITUTION OF HIGHER EDUCATION.