Marshfield Clinic Health System Inc

WISCONSIN NCI COMMUNITY ONCOLOGY RESEARCH PROGRAM (WINCORP)

NATIONAL CHIDREN'S CENTER FOR RURAL AND AGRICULTURAL HEALTH AND SAFETY

ANNUAL ESTIMATES OF INFLUENZA VACCINE EFFECTIVENESS AND EVALUATION OF IMMUNE RESPONSE IN A WISCONSIN POPULATION

CORE_PLUS OPTION_B_C_INFLUENZA VACCINE EFFECTIVENESS IN A WISCONSIN POPULATION

ALL OF US, WISCONSIN

HOUSEHOLD TRANSMISSON OF INFLUENZA VIRUSES IN THE COMMUNITY

PHEWAS AND GWAS OF TELOMERE LENGTH TO UNDERSTAND HUMAN DISEASE

PHEWAS OF LOSS-OF-FUNCTION VARIANTS

LONGITUDINAL SURVEILLANCE OF PRIORITY EXPOSURES AND OUTCOMES AMONG PREGNANT PEOPLE AND INFANTS (COMPONENT A)

TELEHEALTH NETWORK GRANT PROGRAM

TELEHEALTH NETWORK GRANT PROGRAM

UNDERSTANDING AND ADDRESSING THE DISPARITY IN VACCINATION COVERAGE AMONG U.S. ADOLESCENTS LIVING IN RURAL VERSUS URBAN AREAS

MCHS - NORTHWOODS PFS 2024 - AS THE LARGEST, NONPROFIT, INTEGRATED RURAL HEALTHCARE SYSTEM SERVING WISCONSIN, MARSHFIELD CLINIC HEALTH SYSTEM (MCHS), IN PARTNERSHIP WITH COMMUNITY COALITIONS IN FIVE, RURAL WISCONSIN COUNTIES-BARRON, FOREST, ONEIDA, PORTAGE, AND PRICE—WILL IMPLEMENT THE MCHS - SPF-PFS GRANT TO ADDRESS UNDERAGE DRINKING AND PROMOTE MENTAL HEALTH IN THOSE REGIONS. PRIORITY SUBPOPULATIONS TO BE SERVED INCLUDE RURAL, TRIBAL, AND LGBTQ YOUTH. MCHS WILL CAPITALIZE ON ESTABLISHED RELATIONSHIPS WITH PARTNERING COALITIONS AND UTILIZE THE EXPERIENCE OF THE MCHS PREVENTION AND RECOVERY (PAR) TEAM TO PROVIDE CAPACITY BUILDING WITHIN THE COALITIONS AND DELIVER TRAINING AND TECHNICAL SUPPORT FOR IMPLEMENTATION OF EVIDENCE-BASED PREVENTION STRATEGIES CENTERED ON ALCOHOL USAGE. MCHS WILL GUIDE COALITIONS THROUGH THE STRATEGIC PREVENTION FRAMEWORK MODEL AS THEY CONDUCT COMMUNITY ASSESSMENTS, BUILD CAPACITY, IDENTIFY/PLAN STRATEGIES, IMPLEMENT EVIDENCE-BASED STRATEGIES TO REDUCE UNDERAGE DRINKING, AND EVALUATE PROJECT SUCCESS. BUILDING OFF THE COMMUNITY ANTI-DRUG COALITIONS OF AMERICA'S (CADCA) SEVEN STRATEGIES FOR CREATING EFFECTIVE COMMUNITY CHANGE, COALITIONS WILL ALIGN ELECTED STRATEGIES WITH THEIR COMMUNITY NEEDS, INCORPORATING TWO INDIVIDUAL AND ONE ENVIRONMENTAL STRATEGY EACH YEAR, BEGINNING IN YEAR 2, OVER THE FIVE-YEAR PROJECT. COALITIONS WILL ENGAGE IN AN ANNUAL HEALTH EQUITY PROJECT TO PROMOTE CULTURAL COMPETENCY IN DECISION-MAKING AND TO ADVANCE MENTAL HEALTH IN COMMUNITIES. SUPPORT SYSTEMS FOR SUBSTANCE MISUSE AND MENTAL HEALTH CONCERNS ARE LIMITED IN THE TARGET COUNTIES, WHERE CURRENT ALCOHOL USE RATES AMONG YOUTH (28%) EXCEED BOTH THE STATE AND NATIONAL AVERAGES (25.4% AND 22.7% RESPECTIVELY). APPROXIMATELY 78% OF THE COMBINED POPULATION OF FOCUS, OR 139,880 INDIVIDUALS, ARE CONSIDERED RURAL, AND FACE HEALTH DISPARITIES COMMON TO RURAL POPULATIONS. THIS EQUATES TO APPROXIMATELY 23,723 SCHOOL-AGE YOUTH LIVING IN RURAL AREAS. THE REGION ALSO INCLUDES TWO FEDERALLY RECOGNIZED TRIBAL NATIONS—POTAWATOMI AND SOKAOGON CHIPPEWA—AND BORDERS A THIRD, THE OJIBWE CHIPPEWA. THE LGBTQ YOUTH POPULATION, WHICH MAKES UP APPROXIMATELY 3.8% OF TOTAL YOUTH POPULATION, EXPERIENCES HIGHER NUMBERS OF ALCOHOL USE AND MENTAL HEALTH CONCERNS THAN THEIR STRAIGHT/CISGENDER CLASSMATES. PROJECT GOALS INCLUDE THE FOLLOWING: GOAL 1: STRENGTHEN COMMUNITY-LEVEL PREVENTION CAPACITY AND COLLABORATION AMONG COMMUNITY SECTORS TO ADDRESS UNDERAGE DRINKING. GOAL 2: DECREASE UNDERAGE ALCOHOL USAGE BY IMPLEMENTING EVIDENCE-BASED STRATEGIES THAT ADDRESS YOUTH RISK AND PROTECTIVE FACTORS. GOAL 3: INCREASE THE CAPACITY OF COALITIONS TO IMPROVE HEALTH EQUITY, MENTAL HEALTH, AND WELL-BEING AMONG YOUTH. RELATED OBJECTIVES INCLUDE MEASURABLE ACTION STEPS BY COALITIONS, INCLUDING CONDUCTING COMMUNITY ASSESSMENTS, BUILDING CAPACITY WITHIN THEIR COMMUNITIES TO ADDRESS THE ISSUE, PRODUCING A 4-YEAR LOGIC MODEL AND ANNUAL WORK PLANS TO IDENTIFY AND PLAN FOR APPROPRIATE STRATEGIES IMPLEMENTATION, AND EVALUATING THE SUCCESS OF THOSE PROJECTS. OTHER OBJECTIVES REFLECT RISK FACTOR REDUCTION, PROTECTIVE FACTOR PROMOTION, AND CONSUMPTION OR BEHAVIOR OF YOUTH. WHILE THE PROJECT FOCUSES ON DECREASING YOUTH ALCOHOL USAGE, UNIVERSAL AND COMMUNITY LEVEL STRATEGIES WILL BE IMPLEMENTED AND SOCIAL NORMS ADDRESSED. AS SUCH, THE PROJECT WILL IMPACT ENTIRE COMMUNITIES, INCLUDING ADULTS, IN ADDITION TO THE TARGET YOUTH POPULATION. ANNUALLY, THIS PROJECT IS EXPECTED TO REACH UP TO 179,333 INDIVIDUALS, INCLUDING THE TARGETED 34,560 YOUTH AND THEIR RESPECTIVE FAMILIES IN THE FIVE-COUNTY REGION. OVER THE GRANT'S LIFE, ABOUT 896,665 YOUTH AND ADULTS WILL BE REACHED.

HOSPITAL-ASSOCIATED RESPIRATORY VIRUS INFECTIONS: MOLECULAR EPIDEMIOLOGY, CLINICAL OUTCOMES, AND COST-EFFECTIVENESS OF INTERVENTIONS - COVID-19 ADMINISTRATIVE SUPPLEMENT

TELEHEALTH NETWORK GRANT PROGRAM

UNITING A COMMUNITY

DEVELOPMENT AND APPLICATION OF PHENOME-WIDE SCAN OF HERITABILITY (PHESH)

THE ROLE OF COGNITIVE DEVELOPMENT IN SAFE TRACTOR OPERATION: A SIMULATION STUDY

RURAL HEALTH CLINIC VACCINE CONFIDENCE PROGRAM

IDENTIFICATION OF CANDIDATE GENOMIC REGULATORY ELEMENTS INVOLVED IN ORAL CLEFTS - PROJECT SUMMARY/ABSTRACT DISTURBANCES IN THE MOLECULAR PATHWAYS THAT CONTROL LIP AND PALATE DEVELOPMENT DURING EMBRYOGENESIS CAN LEAD TO ORAL CLEFTS, BUT KNOWLEDGE OF THE REGULATORY INTERACTIONS INVOLVED IN MODULATING THE EXPRESSION OF GENES IN THESE PATHWAYS REMAINS LIMITED. BECAUSE ENHANCERS ARE CRITICAL TO THE SPATIOTEMPORAL REGULATION OF GENE EXPRESSION DURING EMBRYOGENESIS, THOSE THAT ARE ACTIVE IN CRANIOFACIAL TISSUES DURING LIP AND PALATE DEVELOPMENT ARE LIKELY TO CONTROL THE EXPRESSION OF GENES RELEVANT TO ORAL CLEFTS. THE OVERALL GOAL OF THE PROPOSED RESEARCH IS TO IDENTIFY INTERACTIONS BETWEEN ENHANCERS, TRANSCRIPTION FACTORS THAT BIND THE ENHANCERS, AND TARGET GENES OF THE ENHANCERS IN LIP AND PALATE DEVELOPMENT AND ORAL CLEFTS. AIM 1 IS TO IDENTIFY THE SUBSET OF ENHANCERS THAT DRIVE GENE EXPRESSION OVERALL IN HUMAN EMBRYONIC PALATAL MESENCHYME CELLS. THE TRANSCRIPTION FACTORS WITH BINDING SITE MOTIFS THAT ARE ENRICHED IN THE ENHANCERS WILL BE IDENTIFIED, AND BINDING OF THE TRANSCRIPTION FACTORS WITHIN THE ENHANCERS IN HUMAN EMBRYONIC PALATAL MESENCHYME CELLS WILL BE CONFIRMED USING ASSAYS OF CHROMATIN IMMUNOPRECIPITATION FOLLOWED BY SEQUENCING. AIM 2 IS TO IDENTIFY ENHANCERS THAT REGULATE TRANSCRIPTION SPECIFICALLY WITHIN HUMAN EMBRYONIC PALATAL MESENCHYME CELLS, BECAUSE SUCH ENHANCERS ARE MORE LIKELY TO BE INVOLVED IN CRANIOFACIAL-SPECIFIC PROCESSES DURING DEVELOPMENT. ENHANCERS THAT CAN DISTINGUISH BETWEEN HUMAN EMBRYONIC PALATAL MESENCHYME CELLS AND OTHER TYPES OF TISSUES AND CELLS WILL BE CONSIDERED PALATE-SPECIFIC ENHANCERS. THE PALATE SPECIFICITY OF A SUBSET OF THE ENHANCERS WILL BE CONFIRMED USING IN VITRO ASSAYS.

RURAL HEALTH CARE SERVICES OUTREACH GRANT PROGRAM

SECONDARY ANALYSIS OF EHR DATA TO EXAMINE RELATIVE IMPACT OF ORAL HEALTH HISTORY ON INCIDENT PNEUMONIA BY SETTINGS

SECONDARY ANALYSIS OF EHR DATA TO ENHANCE CARE OF DENTAL PATIENTS WITH DIABETES

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM-OVERDOSE RESPONSE

TELEHEALTH NETWORK GRANT PROGRAM

SOBER TRUTH ON PREVENTING UNDERAGE DRINKING ACT

COMMUNITY-BASED COALITION ENHANCEMENT GRANTS TO ADDRESS LOCAL DRUG CRISES

2020 NORTH AMERICAN AGRICULTURAL SAFETY SUMMIT

UNITING A COMMUNITY

RURAL HEALTH NETWORK DEVELOPMENT PLANNING GRANT PROGRAM

STATISTICAL DESIGNS AND METHODS

STATISTICAL DESIGNS AND METHODS

CDC-RFA-CE21-2106