Ybh Inc

MECHANISMS OF STATE SWITCHING IN SLEEP AND SLEEP APNEA

NEIGHBORHOOD STABILIZATION PRG

DAMP-MEDIATED INNATE IMMUNE FAILURE AND PNEUMONIA AFTER TRAUMA

FUTILITY STUDY OF DEFEROXAMINE MESYLATE IN INTRACEREBRAL HEMORRHAGE (HI-DEF)

ENTITLED CITIES

ENTITLED CITIES

NATIONAL CENTER FOR FUNCTIONAL GLYCOMICS

MECHANISMS OF PROSTHETIC ARTERIAL GRAFT FAILURE

3/8 - PREDICTORS AND MECHANISMS OF CONVERSION TO PSYCHOSIS

STATE DEPENDENT ASPECTS OF COGNITION

RESEARCH RESOURCE FOR COMPLEX PHYSIOLOGIC SIGNALS

BIPOLAR & SCHIZOPHRENIA CONSORTIUM FOR PARSING INTERMEDIATE PHENOTYPES

METABOLIC ACTIONS OF FGF21

HOME INVESTMENT CPD

IN VIVO OPTICAL DETECTION OF DYSPLASIA IN ESOPHAGUS

CARDIOVASCULAR RESEARCH TRAINING PROGRAM

HARVARD HEPATITIS B CONSORTIUM

TARGETING TUMOR SUPPRESSIVE PATHWAYS FOR CANCER THERAPY

TARGETING PML FOR LEUKEMIA THERAPY.

HUMAN EOSINOPHILS: MECHANISMS OF FUNCTIONING

HOME INVESTMENT CPD

EFFICACY OF OPEN-LABEL PLACEBO, DOUBLE-BLIND PLACEBO, AND PEPPERMINT OIL IN IBS

APOL1 VARIANTS: UNDERSTANDING THE BASIS OF DISPARITIES IN RATES OF KIDNEY DISEASE

TLR4 SIGNALING IN ALCOHOLIC LIVER DISEASE

TARGETING THE ENDOTHELIUM IN SEPSIS

MECHANISMS UNDERLYING THE BLOOD PRESSURE LOWERING EFFECT OF SLEEP EXTENSION.

GLYCOPROTEOMICS AND THE GLYCOSYLATION CODE OF THE BRAIN IN ASYMPTOMATIC AND SYMPTOMATIC ALZHEIMER?S DISEASE

ULTRASENSITIVE C.DIFFICILE TOXIN MEASUREMENT FOR DIAGNOSIS AND OUTCOME PREDICTION

PERFUSION MRI FOR MULTISITE STUDIES OF BRAIN FUNCTION

MEMORY ADVANCEMENT BY INTRANASAL INSULIN IN TYPE 2 DIABETES (MEMAID)

MOLECULAR GENETICS OF INHERITED FOCAL GLOMERULEROSIS

BIOLOGICAL MECHANISM OF FSGS-1

ANALYSIS OF BRCA1 RECOMBINATION FUNCTIONS

MECHANISMS OF INNATE MODULATION OF SIV RESERVOIRS AND OPPORTUNISTIC DISEASE IN THE ORAL CAVITY

ROCK1 SIGNALING IN GLUCOSE METABOLISM

PROTEOMIC PATHWAY DISCOVERY IN CARDIOVASCULAR DISEASE

MICRORNAS IN AGING

VASCULAR THIOL ISOMERASES IN THROMBOSIS

DEVELOPMENT OF SELECTIVE PIN1 INHIBITORS TO TARGET A COMMON ONCOGENIC MECHANISM

IMPACT OF CIRCADIAN RHYTHM IN OBTAINING REFERENCE PROFILES OF EXRNAS IN HEALTHY I

PHOTOPHOBIA DURING MIGRAINE: SENSORY, AUTONOMIC AND EMOTIONAL RESPONSES TO LIGHT

SLEEP SPINDLES IN EARLY COURSE SCHIZOPHRENIA AND FIRST-DEGREE RELATIVES

BUILDING CAPACITY OF THE VIETNAM HEALTH SYSTEM THROUGH PROVISION OF HIV/AIDS CLINICAL CARE MENTORSHIP AND TECHNICAL ASSISTANCE UNDER THE PRESIDENTS EMERGENCY PLAN FOR AIDS RELIEF (PEPFAR)

RESEARCH TRAINING IN GASTROENTEROLOGY

TAI CHI AFTER PULMONARY REHABILITATION IN PATIENTS WITH COPD: A RANDOMIZED TRIAL

CLINICAL CENTERS (CC) FOR THE NHLBI PREVENTION AND EARLY TREATMENT OF ACUTE LUNG

RANDOMIZED TRIAL OF A MAMMOGRAPHY DECISION AID FOR WOMEN AGED 75 AND OLDER

NON-INVASIVE BRAIN STIMULATION FOR SWALLOWING RECOVERY AFTER A DYSPHAGIC STROKE

HYPOTHALAMIC AROUSAL SYSTEMS

IMPACT OF FATTY ACID IMBALANCE IN INTESTINAL HEALTH AND DISEASE IN PREMATURITY

PAIN SENSITIZATION AND HABITUATION IN A MODEL OF EXPERIMENTALLY-INDUCED INSOMNIA SYMPTOMS

(PQ7) IN VIVO CELLULAR OPTICAL IMAGING OF ESOPHAGEAL TUMORS AND MICROENVIRONMENT

FACILE SYNTHESIS OF GLYCOSULFOPEPTIDES AND RELATED BIOCONJUGATES

A PSGL-1 GLYCOPEPTIDE MIMETIC FOR TREATMENT OF METABOLIC SYNDROME

TRANSCRIPTION FACTORS AS THERAPEUTIC TARGETS IN FOCAL SEGMENTAL GLOMERULAR SCLEROSIS

BIOENGINEERED RED BLOOD CELLS AS EXTRACELLULAR VESICLE-MEDIATED DELIVERY PLATFORMS FOR GENE EDITING MACHINERY

DELIVERY TECHNOLOGIES FOR IN VIVO GENOME EDITING

BRAINSTEM REGULATION OF SLEEP

THIS AWARD FUNDS THE APPROVED 2022-23 RSVP PROGRAM. YOUR 2022-23 STATUTORY MATCH IS 30% AND YOUR BUDGETARY MATCH IS 55.4%.

CORTICAL PLASTICITY IN AUTISM SPECTRUM DISORDERS

RAIL INFRASTRUCTURE

TGFBETA-MEDIATED TRANSCRIPTIONAL REPROGRAMMING OF MATURE ADIPOCYTES IN OBESITY

CONTROL OF ENERGY BALANCE BY APOJ SIGNALING

APOJ AS A NOVEL HEPATOKINE TARGETING MUSCLE GLUCOSE METABOLISM

GLUTAMATERGIC NEURONS IN THE ARCUATE NUCLEUS (ARC) AND REGULATION OF SATIETY

NEURAL PATHWAY LINKING NUTRITIONAL STATE TO FOOD-CUE RESPONSES IN INSULAR CORTEX

HOPWA (FORMULA)

SPATIOTEMPORAL NETWORK DYNAMICS IN A RAT MODEL OF SCHIZOPHRENIA

NEUROBIOLOGY OF AGGRESSION COMORBIDITY IN AUTISM

HOPWA (FORMULA)

GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES

COMBATING RESISTANCE TO ANTIANGIOGENIC THERAPY IN RENAL CELL CARCINOMA

MIR-199~214 CLUSTER AT THE CROSSROADS OF PLASTICITY AND MALIGNANCY IN BREASTCANCER

EXPLOITING METABOLIC VULNERABILITIES IN THE PI3K AND AKT PATHWAY IN CANCER FOR THERAPEUTIC BENEFIT

CHARACTERIZING THE SIGNALING PATHWAYS THAT REGULATE SKP2 ONCOGENIC FUNCTION

ROLE OF BILIVERDIN REDUCTASE DURING STERILE INFLAMMATION IN THE LIVER.

MAPPING BRAINSTEM CONTROL OF CONTINENCE

TARGETING THE APC/CDC20 E3 UBIQUITIN LIGASE FOR CHEMORADIATION SENSITIZATION

BASAL FOREBRAIN HYPOTHALAMIC NETWORKS SUPPORTING WAKEFULNESS

NEURAL MECHANISMS UNDERLYING REM SLEEP REGULATION BY MCH NEURONS

PERIPHERAL MECHANISMS OF POSTTRAUMATIC HEADACHE

NEXT GENERATION ELECTRICAL IMPEDANCE MYOGRAPHY: THE VIRTUAL MUSCLE BIOPSY

PARABRACHIAL NUCLEUS CONTROL OF AROUSAL

APICAL ABSCISSION AND PERIVENTRICULAR HETEROTOPIA: A COMMON BASIS FOR DISEASE

DYSREGULATED SIGNALING IN CROHN'S DISEASE

BRAFV600E AND VEGFR2 SYNERGIZE TO TRIGGER PAPILLARY THYROID CANCER PROGRESSION

COMPLEX ROLE OF HSF1 IN BREAST CANCER

DRUG DISCOVERY AGAINST THE EARLY, SECRETED AND TOXIC TAU IN ALZHEIMER'S DISEASE

NOVEL MECHANISMS OF DISARMING ANTI-HIV HOST DEFENSES BY METHAMPHETAMINE

ALTERED CELL-CELL COUPLING IN ARRHYTHMOGENIC CARDIOMYOPATHY

A PSGL-1 GLYCOPEPTIDE MIMETIC FOR TREATMENT OF VENOUS THROMBOEMBOLISM

THE ROLE OF TBI DERIVED DAMPS IN BACTERIAL PNEUMONIA

HIV-SPECIFIC RESPONSES MEDIATED BY HUMAN NK CELLS

DRUG INHIBITION OF KCA3.1 CHANNEL KCNN4 AS A STRATEGY TO RETARD CYST GROWTH AND DISEASE PROGRESSION IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

TAS::97 0130::TAS "ROLE OF COMPLEMENT IN RED CELL DYSFUNCTION IN TRAUMA: A PROSPECTIVE STUDY"

MECHANISMS OF MOSAIC HETEROGENEITY IN ENDOTHELIUM

UNDERSTANDING THE MECHANISMS OF TRPC6 MEDIATED FSGS

AUTOCRINE REGULATION OF NEUTROPHIL CHEMOTAXIS

PLASMID EVICTION TO RESTORE SUSCEPTIBILITY IN CARBAPENEM-RESISTANT ENTEROBACTERIACEAE

LEPTIN AND ADIPOKINE PHYSIOLOGY

LEVERAGING A SOCIAL NETWORK OF ELDERS AND FAMILIES TO IMPROVE MEDICATION SAFETY AT TRANSITIONS OF CARE

ANSWERING THE CALL TO ENGAGE PATIENTS AND FAMILIES IN THE DIAGNOSTIC PROCESS: A NEW PATIENT-CENTERED APPROACH USING HEALTH INFORMATION TRANSPARENCY TO IDENTIFY DIAGNOSTIC BREAKDOWNS IN AMBULATORY CARE

USING AFFINITY-BASED PROTEOMICS TO IDENTIFY DIAGNOSTIC AND PLASMA BIOMARKERS FOR ENDOMETRIOSIS

TRAINING PROGRAM IN SYSTEMIC AUTOIMMUNITY

IDENTIFICATION OF RISK AND EARLY DETECTION BIOMARKERS FOR LIVER CANCER

IMPROVING SAFETY OF TRANSITIONS TO SKILLED NURSING CARE USING VIDEO-CONFERENCING

PERSONALIZED COMPUTATIONAL MODELING TO SUPPORT EFFECTIVE USE OF BACK SUPPORT EXOSUITS TO PREVENT BACK INJURIES

THIS AWARD FUNDS THE APPROVED 2025-26 AMERICORPS SENIORS RSVP PROGRAM. YOUR 2025–26 STATUTORY MATCH REQUIREMENT IS 10% AND YOUR BUDGETED MATCH IS 49.93%. YOU ARE APPROVED FOR PREAWARD COSTS FROM 4/1/25 - 5/1/25.

NPM1 REGULATION OF 2'-O-METHYLATION IN HEMATOPOIESIS AND BONE MARROW FAILURE DISORDER

FUNCTIONAL ANALYSIS OF A TISSUE CONTEXT-DEPENDENT ROLE FOR BETA-TRCP IN LIPID METABOLISM AND TUMORIGENESIS

HEALTH OF THE MUSCULOSKELETAL SYSTEM DEPENDS ON EXPOSURE TO MECHANICAL LOADING. REMOVAL OR REDUCTION OF MECHANICAL LOADING PRECIPITATES MUSCLE ATROPH

TARGETING MECHANISMS DRIVING ERBB2 ACTIVATION IN SUBSETS OF CRPC

THIAMINE V PLACEBO TO IMPROVE OXYGEN CONSUMPTION AFTER IN-HOSPITAL CARDIAC ARREST

LEGAL ASSISTANCE FOR VICTIMS OF DOMESTIC VIOLENCE, STALKING, SEXUAL ASSAULT AND DATING VIOLENCE

THE RURAL DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING PROGRAM (RURAL PROGRAM) IS AUTHORIZED BY 34 U.S.C. § 12341. RURAL PROGRAM FUNDS ARE USED TO SUPPORT PROGRAMS THAT: A) IDENTIFY, ASSESS, AND APPROPRIATELY RESPOND TO CHILD, YOUTH, AND ADULT VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING IN RURAL COMMUNITIES; B) ESTABLISH AND EXPAND VICTIM SERVICES IN RURAL COMMUNITIES FOR CHILD, YOUTH, AND ADULT VICTIMS; AND/OR C) INCREASE THE SAFETY AND WELL-BEING OF WOMEN AND CHILDREN IN RURAL COMMUNITIES BY DEALING DIRECTLY AND IMMEDIATELY WITH DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING, AND CREATING AND IMPLEMENTING STRATEGIES TO INCREASE AWARENESS AND PREVENT THESE CRIMES. GRANTEES MUST USE AT LEAST ONE OF THE FOLLOWING STRATEGIES IN IMPLEMENTING THEIR PROJECTS: A) IMPLEMENT, EXPAND, AND ESTABLISH COOPERATIVE EFFORTS AND PROJECTS AMONG LAW ENFORCEMENT OFFICERS, PROSECUTORS, VICTIM SERVICE PROVIDERS, AND OTHER RELATED PARTIES TO INVESTIGATE AND PROSECUTE INCIDENTS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING; B) PROVIDE TREATMENT, COUNSELING, ADVOCACY, LEGAL ASSISTANCE, AND OTHER LONG- AND SHORT-TERM ASSISTANCE TO ADULT AND MINOR VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING IN RURAL COMMUNITIES; C) WORK IN COOPERATION WITH THE COMMUNITY TO DEVELOP EDUCATION AND PREVENTION STRATEGIES DIRECTED TOWARD SUCH ISSUES; D) DEVELOP, ENLARGE, OR STRENGTHEN PROGRAMS ADDRESSING SEXUAL ASSAULT; AND E) DEVELOP PROGRAMS AND STRATEGIES THAT FOCUS ON THE SPECIFIC NEEDS OF VICTIMS WHO RESIDE IN REMOTE RURAL AND GEOGRAPHICALLY ISOLATED AREAS.    THE TIMING FOR PERFORMANCE OF THIS AWARD IS 36 MONTHS.

DEMOGRAPHICS CAUSES AND CONSEQUENCES OF B CELL REPERTOIRE DIVERSITY

RURAL SEXUAL ASSAULT, DOMESTIC VIOLENCE, DATING VIOLENCE AND STALKING ASSISTANCE PROGRAM TARGETING AFRICAN AMERICANS AGES 13-24.

CULTURALLY SPECIFIC SERVICES FOR YOUTH AND YOUNG ADULT VICTIMS OF INTERPERSONAL VIOLENCE IN THE MISSISSIPPI DELTA

AIR POLLUTION AND THE LUNG IN HEALTH AND COPD: OBSTRUCTIVE, RESTRICTIVE AND VASCULAR PATHWAYS

LONGITUDINAL IMAGING STUDIES IN BIPOLAR DISORDER

DIGITAL PHENOTYPING FOR COMPUTATIONAL MODELS OF RELAPSE PREDICTION IN EARLY COURSE PSYCHOSIS

CHARACTERIZATION OF BROADLY NEUTRALIZING ANTIBODIES AGAINST JC VIRUS

DIVERSITY OF IMMUNE RESPONSES ELICITED BY HIV VACCINES

INTEGRATIVE, MULTI-PARAMETRIC CHARACTERIZATION OF THE EV SURFACE PROTEIN AND NUCLEIC ACID LANDSCAPE BY NANO-FLOW AND SORTING CYTOMETRY

RISK-ADAPTED THROMBOPROPHYLAXIS OF HOSPITALIZED CANCER PATIENTS

BROADBAND MULTISPECTRAL MICROSCOPY OF INSULIN GRANULE DYNAMICS IN LIVE PANCREATIC ISLETS -DIABETES IS A CHRONIC DISEASE CHARACTERIZED BY A HIGH BLOOD SUGAR LEVEL OVER AN EXTENDED PERIOD OF TIME. AS OF 2019, IT WAS ESTIMATED THAT 463 MILLION PEOPLE WORLDWIDE OR ALMOST 9% OF THE WORLD ADULT POPULATION, HAD DIABETES, WITH RATES CONTINUING TO RISE. THE HALLMARK OF DIABETES IS THE FAILURE OF INSULIN SECRETING BETA CELLS LOCATED IN THE PANCREAS. THE BETA CELL IS THE ONLY CELL IN THE BODY THAT SECRETES INSULIN, WHICH IN TURN IS THE ONLY HORMONE ABLE TO LOWER PLASMA GLUCOSE LEVELS. GIVEN THE IMPORTANCE OF BETA CELLS, NUMEROUS METHODS HAVE BEEN APPLIED TO STUDY THEIR PHYSIOLOGY. BETA CELLS STORE INSULIN IN SMALL COMPARTMENTS CALLED INSULIN GRANULES AND WHEN BLOOD SUGAR LEVELS RISE, THESE GRANULES FUSE WITH THE CELL MEMBRANE, ALLOWING BETA CELLS TO RELEASE LARGE QUANTITIES OF INSULIN AT ONCE. UNFORTUNATELY, DIRECT VISUALIZATION OF INSULIN GRANULES IS NOT STRAIGHTFORWARD, SINCE CURRENT METHODS REQUIRE EXTERNAL LABELS THAT CAN AFFECT GRANULE FUNCTION AND DYNAMICS. THE TEAM OF INVESTIGATORS HAS BEEN DEVELOPING A STRAIGHTFORWARD OPTICAL MICROSCOPIC TECHNIQUE CALLED CONFOCAL BROADBAND BACKSCATTERING MICROSCOPY (CBBM) THAT CAN VISUALIZE INSULIN GRANULES WITHOUT ANY LABELS AND MONITOR THEIR DYNAMICS OVER THE COURSE OF HOURS AND EVEN DAYS, WHICH COULD POTENTIALLY LEAD TO A NEW TREATMENT FOR DIABETES. PROJECT OUTCOMES AND EFFORTS WILL BE INTEGRATED INTO A COURSE ON OPTICAL MICROSCOPY IN BIOLOGY; PROVIDE TRAINING OPPORTUNITIES FOR UNDERGRADUATE, GRADUATE, AND POST GRADUATE STUDENTS; AND ENHANCE RESEARCH EXPERIENCES FOR K-12 STUDENTS. THE OVERARCHING GOAL OF THIS PROJECT IS TO DEVELOP A LABEL-FREE MICROSCOPY SYSTEM FOR FUNCTIONAL IMAGING AND CONTINUOUS MONITORING OF INSULIN GRANULES IN LIVE PANCREATIC ISLETS IN A CUSTOM ISLET-ON-A-CHIP. THE APPROACH WILL COMBINE NOVEL CONFOCAL BROADBAND BACKSCATTERING MICROSCOPY (CBBM) WITH THE EXISTING CONFOCAL FRET AND SUPER-RESOLUTION STORM MODALITIES, WITH ALL THREE SHARING A MAJOR PART OF THE OPTICAL TRAIN AND HAVING A COMMON FIELD OF VIEW. THE CBBM TECHNIQUE WILL PROVIDE A FUNCTIONAL IMAGE OF A BETA CELL, RESOLVE INSULIN GRANULES, MONITOR THE CONVERSION OF PROINSULIN INTO INSULIN INSIDE THE GRANULES, AND VISUALIZE GRANULE-BASED INSULIN INTERCELLULAR TRANSPORT. THE PROJECT WILL ALSO DEVELOP A PHYSICAL AND MATHEMATICAL MODEL TO DESCRIBE LIGHT SCATTERING FROM INSULIN GRANULES WITHIN THE CONFOCAL VOLUME OF THE LABEL-FREE MICROSCOPY SYSTEM AND AN INVERSE ALGORITHM TO DIFFERENTIATE INSULIN AND NON-INSULIN GRANULES LABEL-FREE. THESE ALGORITHMS WILL BE USED TO MONITOR TEMPORAL CHANGES IN GRANULES AND CONTINUOUSLY VISUALIZE THEM IN 3D DURING INSULIN INTERCELLULAR TRANSPORT AND RELEASE. TO BETTER UNDERSTAND ISLET FUNCTION AND THE OPTIMAL ENVIRONMENTS FOR TRANSPLANTABLE ISLETS, GLUCOSE EXCHANGES WILL BE COMBINED WITH IN VIVO FUNCTIONAL IMAGING IN HUMAN PANCREATIC ISLETS, ALLOWING INVESTIGATION OF IMPORTANT FEEDBACK LOOPS IN GLUCOSE/INSULIN CYCLES. EXPERIMENTS WILL ALSO BE PERFORMED TO INVESTIGATE CRITICAL DIFFERENCES BETWEEN ISLETS DERIVED FROM DIABETIC AND HEALTHY SUBJECTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

IMPROVING USE OF SEDATING MEDICATIONS IN HOSPITALIZED OLDER ADULTS

COUPLING TECHNOLOGY WITH MIND-BODY EXERCISE TO FACILITATE PHYSICAL ACTIVITY IN PATIENTS WITH CHRONIC CARDIOPULMONARY DISEASE

RURAL (INTERVENTION & PREVENTION) INTERPERSONAL VIOLENCE PROJECT

MECHANISMS OF EXTRACELLULAR MATRIX MEDIATED DRUG RESISTANCE

DETERMINING THE ROLE OF DNMT-INTERACTING RNAS IN MYELOID DISORDERS

ROLE OF VITAMIN B5 AND COENZYME A METABOLISM IN PI3K DRIVEN TUMORIGENESIS

ACTIVE SURVEILLANCE OF CARDIOVASCULAR DEVICES: THE MULTI-REGISTRY DELTA NETWORK

DECREASING ADVERSE BIRTH OUTCOMES AMONG HIV-INFECTED WOMEN ON ANTIRETROVIRAL THERAPY

INSTRUMENTATION FOR NONINVASIVE MEASUREMENT OF GLUCOSE AND ENERGY BALANCE IN MICE WITH CONTINUOUS GLUCOSE TELEMETRY AND INDIRECT CALORIMETRY

AGE-RELATED CHANGES IN THORACIC SPINE BIOMECHANICS

A MULTISTAKEHOLDER EXAMINATION OF THE DRIVERS AND VALUE OF INPATIENT CONSULTATION

GLAUCOMA EPIGENETIC TREATMENT WITH LIGHT ACTIVATED CRISPR-DCAS9

NOVEL RNA-BASED THERAPIES FOR LUNG CANCER

SINGLE CELL TRANSCRIPTOME PROFILING TO DEFINE CELL TYPES IN BRAIN NUCLEI CONTROLLING BLADDER FUNCTION

PRE-CLINICAL EVALUATION OF A NEUTROPHIL ELASTASE INHIBITOR FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE

DISCOVERING NEW DRUG TARGETS IN RADIATION-INDUCED MYELOPROLIFERATIVE NEOPLASMS

FUNCTIONAL NEUROIMAGING OF URINE STORAGE AND VOIDING IN MICE

THROMBOPROPHYLAXIS WITH ROSUVASTATIN FOLLOWING SURGERY FOR OVARIAN CANCER

INTRAVASCULAR MOLECULAR-STRUCTURAL IMAGING OF CORONARY STENT PATHOBIOLOGY

PORT SECURITY GRANT PROGRAM

AUTOPHAGY-PROTEASOME CROSS-TALK IN PARKINSON'S PATHOGENESIS

ANALYSIS OF THE TANDEM DUPLICATOR PHENOTYPE AS A NEW DRIVER AND BIOMARKER OF BRCA1-LINKED TO OVARIAN CANCER

COLLABORATIVE RESEARCH: SCH: MACHINE LEARNING DRIVEN USER INTERFACES FOR INFORMATION GATHERING AND SYNTHESIS FROM MEDICAL RECORDS -CLINICIANS HAVE TO SEARCH THROUGH A PATIENT?S PAST MEDICAL RECORDS TO CONTEXTUALIZE THE PATIENT?S CONDITION AND REACH A PERSONALIZED DIAGNOSIS AND TREATMENT PLAN. HOWEVER, USER INTERFACES IN HEALTHCARE ARE UNWIELDY TO NAVIGATE AND ARE LARGELY A DIGITIZATION OF STATIC PAPER FORMS FROM LEGACY CLINICAL WORKFLOWS, A PARADIGM THAT HAS CONTRIBUTED TO POOR USABILITY AND CLINICIAN BURNOUT. THIS PROJECT BRINGS TOGETHER EXPERTS IN MACHINE LEARNING AND HUMAN-COMPUTER INTERACTION TO DEVELOP A NOVEL DYNAMIC CONTEXTUAL USER INTERFACE THAT TRANSFORMS THE MEDICAL NOTE-TAKING INTERFACE FROM A SIMPLE RECORDING DEVICE TO A TOOL THAT CAN HELP CLINICIANS QUICKLY FIND AND SYNTHESIZE INFORMATION. THE PROJECT?S NOVELTIES ARE IN ADVANCING THE FOUNDATIONS OF HUMAN-AI INTERACTION AND IN ADVANCING THE STATE-OF-THE-ART IN ARTIFICIAL INTELLIGENCE FOR HEALTH CARE WITH NOVEL METHODS THAT AUTONOMOUSLY RETRIEVE, SUMMARIZE, AND SURFACE RELEVANT INFORMATION FOR CLINICIANS, AT THE RIGHT TIME. THE PROJECT?S IMPACTS ARE IN AN AREA OF NATIONAL PRIORITY, HEALTH IT, AS IT AIMS TO MODERNIZE ELECTRONIC HEALTH RECORDS. THE RESULTING SYSTEM WILL HELP PREVENT SUBTLE FINDINGS FROM BEING OVERLOOKED, PATIENTS FROM BEING MISDIAGNOSED, AND CRITICAL INTERVENTIONS FROM BEING MISSED, ULTIMATELY RESULTING IN A DECREASE IN MORBIDITY, MORTALITY, AND OVERALL COST OF HEALTH CARE. IT WILL ADDITIONALLY DECREASE DOCUMENTATION BURDEN AND MITIGATE PHYSICIAN BURNOUT. PRIOR ATTEMPTS AT DEVELOPING CONTEXTUAL DISPLAYS OF PATIENT INFORMATION WERE MANUAL, LABOR-INTENSIVE PROCESSES THAT RELIED ON DOMAIN EXPERTISE AND WERE NEITHER SCALABLE, MAINTAINABLE, NOR CUSTOMIZED TO INDIVIDUAL USERS. AUTOMATING CONTEXTUAL DISPLAYS IS CHALLENGING BECAUSE WHAT INFORMATION IS RELEVANT HIGHLY DEPENDS ON THE USER, PATIENT, AND SPECIFIC CLINICAL CONTEXT. TRADITIONAL MACHINE LEARNING APPROACHES ARE INFEASIBLE BECAUSE OF THE LACK OF LABELED TRAINING DATA. THIS PROJECT DEVELOPS NEW USER INTERFACES THAT ENABLE THE LARGE-SCALE COLLECTION OF IMPLICIT USAGE-BASED TRAINING DATA AS PART OF ROUTINE USER WORKFLOWS. SPECIFICALLY, THIS PROJECT DEVELOPS A NOVEL INFORMATION FORAGING INTERFACE, THE ?SEMANTIC CLIPBOARD?, WHICH CLINICIANS WILL USE WHILE READING PATIENTS? PAST MEDICAL RECORDS AND WHILE WRITING NOTES. USING THE DATA COLLECTED THROUGH THIS NEW INTERFACE, THE INVESTIGATORS WILL DEVELOP NEW MACHINE LEARNING METHODOLOGIES TO PREDICT THE RELEVANT PIECES OF INFORMATION THAT SHOULD APPEAR IN THESE CONTEXTUAL DISPLAYS, CUSTOMIZED TO THE CLINICAL SCENARIO AS WELL AS THE USER. THROUGH THIS PROJECT AND THE INVESTIGATORS? ACADEMIC TEACHING, A NEW GENERATION OF CROSS-DISCIPLINARY RESEARCHERS WILL BE EDUCATED: GRADUATE STUDENTS WHO UNDERSTAND THE FUNDAMENTAL CHALLENGES OF HUMAN COMPUTER INTERACTION, MACHINE LEARNING, AND CLINICAL MEDICINE, AND MEDICAL FELLOWS WHO UNDERSTAND MACHINE LEARNING AND THE SUBTLETIES OF DEPLOYING MACHINE LEARNING IN HEALTH CARE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

SEXUAL ASSAULT SERVICES FOR AFRICAN AMERICANS (BLACKS) IN THE MISSISSIPPI DELTA

EFFECTS OF PALMITIC ACID ESTERS OF HYDROXY STEARIC ACIDS (PAHSAS) ON INTESTINAL MUCOSAL BIOLOGY FOR THE TREATMENT OF TYPE 2 DIABETES

OVERCOMING HYPOMETHYLATING AGENTS' TOXICITY AND NONSPECIFICITY USING AN APTAMER-BASED STRATEGY TO CORRECT ABERRANT DNA METHYLATION IN MYELODYSPLASTIC SY

SOCIAL AND BEHAVIORAL INTERVENTIONS TO INCREASE SOLID ORGAN AND TISSUE DONATION

CLINICAL IMPLICATIONS OF BLOOD PRESSURE PATTERNS AMONG OLDER ADULTS

BEHAVIOR-DEPENDENT NEUROMODULATION OF RETINOGENICULATE AXONAL BOUTONS

BETH ISRAEL DEACONESS MEDICAL CENTER, INC

BIOSENSING OF CHROMATIN PACKING IN LIVE CELLS -IN ORDER TO PACK A TWO-METER-LONG DNA MOLECULE THAT CONTAINS THE GENETIC CODE OF AN ORGANISM INTO A SEVERAL-MICRON SIZED NUCLEUS, THE MOLECULE COMPACTS INTO A DENSE STRUCTURE CALLED CHROMATIN. SOME PARTS OF CHROMATIN DISPLAY A MORE OPEN FORM CALLED EUCHROMATIN, WHICH IS CHARACTERISTIC OF HIGH GENE EXPRESSION, WHILE OTHERS EXHIBIT A MORE DENSELY PACKED CHROMATIN CALLED HETEROCHROMATIN. CURRENTLY, THERE IS NO BIOSENSING TECHNOLOGY CAPABLE OF SENSING THE CONVERSION FROM HETEROCHROMATIN TO EUCHROMATIN AND BACK IN REAL TIME, WHICH IS A CRITICALLY IMPORTANT QUESTION FOR UNDERSTANDING HOW CELLS FUNCTION AND HOW THE HUMAN GENOME IS REGULATED. THUS, THE GOAL OF THIS PROJECT IS TO DEVELOP A METHOD FOR DYNAMIC BIOSENSING OF CHROMATIN PACKING IN LIVE CELLS AND TO ACHIEVE THIS WITHOUT EMPLOYING EXTERNAL MARKERS THAT CAN AFFECT CELL FUNCTION AND, AS A RESULT, CHROMATIN DYNAMICS. THIS WILL BE ACHIEVED BY USING PROPERTIES OF SCATTERED LIGHT, WHICH CARRIES INFORMATION ABOUT THE OBJECT IT IS SCATTERED BY, EVEN IF THE STRUCTURE OF THE OBJECT IS SO TINY THAT REGULAR MICROSCOPES CANNOT RESOLVE IT. AN IMPORTANT PART OF THIS PROJECT WILL BE AN EDUCATIONAL OUTREACH PROGRAM TO SHARE THE TECHNOLOGY WITH UNDERREPRESENTED GROUPS AND K-12 STUDENTS. THIS OUTREACH PROGRAM IS DESIGNED TO REACH K-12 EDUCATIONALLY DISADVANTAGED STUDENTS FROM LOCAL NEIGHBORHOODS WITH PREDOMINANTLY ETHNIC-MINORITY STUDENT POPULATIONS. THE NOVEL LABEL-FREE TECHNOLOGY FOR DYNAMIC BIOSENSING OF CHROMATIN PACKING IN LIVE CELLS, PROPOSED IN THIS APPLICATION WILL ADDRESS FUNDAMENTAL UNSOLVED PROBLEMS IN GENETICS AND EPIGENETICS. IT SHOULD HELP TO ANSWER A POORLY UNDERSTOOD QUESTION OF HOW SIGNAL TRANSDUCTION PATHWAYS DIRECTLY COMMUNICATE WITH CHROMATIN TO CHANGE THE EPIGENETIC LANDSCAPE. IT CAN ALSO FACILITATE A NOVEL SYNTHETIC BIOLOGY BIOSENSING APPROACH AS CHROMATIN CAN SERVE AS A SENSOR OF METABOLIC CHANGES DURING EARLY DEVELOPMENT. IT SHOULD ALSO HAVE IMPORTANT IMPLICATIONS IN PUBLIC HEALTH, INCLUDING CHROMATIN CHANGES IN CANCER OR THE ROLE OF EPIGENETICS IN INFECTIOUS DISEASES. THE APPROACH WILL ADVANCE BOTH ENGINEERING AND LIFE SCIENCES AND WILL BE BASED ON A COMBINATION OF THE PRINCIPLES OF FRACTAL SENSING, SINCE IT IS KNOWN THAT CHROMATIN IN LIVE CELLS IS ORGANIZED AS A FRACTAL WITH HETEROCHROMATIN AND EUCHROMATIN DOMAINS EXHIBITING DIFFERENT FRACTAL DIMENSIONS, AND COHERENT CONFOCAL LIGHT ABSORPTION AND SCATTERING SPECTROSCOPIC MICROSCOPY. THE PROPOSED APPROACH IS MOTIVATED BY THE NEW FUNDAMENTAL INSIGHTS THAT SELF-SIMILAR PROPERTIES OF THE CHROMATIN FRACTAL ARE REFLECTED IN THE CHROMATIN LIGHT SCATTERING SPECTRA, AND THESE SPECTRA CAN BE CONTINUOUSLY AND RAPIDLY RECORDED CREATING A 3D DYNAMIC MAP OF CHROMATIN ON A MULTITUDE OF SPATIAL AND TEMPORAL SCALES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

CHARACTERIZATION OF SLEEP BEHAVIOR IN A RODENT MODEL OF HEADACHE

MICROSCOPY-BASED ANTIMICROBIAL SUSCEPTIBILITY TESTING (MAST)

USP30 AS A THERAPEUTIC TARGET IN PARKINSON?S DISEASE

ROLE OF INSULIN RECEPTOR-MEDIATED SIGNALING IN UNDERACTIVE BLADDER

BIOENGINEERING OF VEIN GRAFTS TO RESIST INTIMAL HYPERPLASIA

CHRONIC TWO-PHOTON CALCIUM IMAGING OF INTRACRANIAL MENINGEAL AFFERENTS IN AWAKE BEHAVING MICE

MITOCHONDRIAL MECHANISMS AND VULNERABILITY TO ALPHA-SYNUCLEIN TOXICITY

THE ROLE OF TLR4-DEPENDENT STERILE INFLAMMATION IN MEDIATING ADVERSE OUTCOMES AFTER SAH

APRAMYCIN SCAFFOLD EXPLORATION USING NOVEL GLYCOCHEMISTRY AND SAR STUDIES TO ENHANCE ACTIVITY AGAINST ACINETOBACTER BAUMANNII AND OTHER MULTIDRUG-RESISTANT GRAM-NEGATIVE PATHOGENS

SEX-SPECIFIC DIFFERENCES IN THE DEVELOPMENT OF ANTHRACYCLINE CARDIOTOXICITY

POTENTIAL ROLE OF HETEROCHROMATIN PROTEIN 1? IN THE CONTROL OF FOXP3 STABILITY AND EXPRESSION IN INDUCED CD4+ REGULATORY T CELLS

INFLUENZA-SPECIFIC MEMORY RESPONSES MEDIATED BY HUMAN NK CELLS

OPTIMIZATION AND DELINEATION OF OPTOKINETIC STIMULATION GLASSES FOR THE TREATMENT OF HEMISPATIAL NEGLECT

SOCIAL AND BEHAVIORAL INTERVENTIONS TO INCREASE SOLID ORGAN AND TISSUE DONATION

THERAPEUTIC VULNERABILITIES ASSOCIATED WITH PTEN MISSENSE MUTATIONS

DETERMINING THE ROLE OF GAS METABOLITE IN RESPONSE TO IMMUNOTHERAPY - PROJECT SUMMARY LUNG CANCER IS A LEADING CAUSE OF DEATH AND THE SECOND MOST COMMON CANCER IN THE UNITED STATES. APPLICATION OF IMMUNOTHERAPIES HAS LED TO SIGNIFICANT IMPROVEMENT IN SURVIVAL OF CANCER PATIENTS. HOWEVER, THERE IS FURTHER NEED TO ACHIEVE BETTER RESPONSES TO CURRENT IMMUNOTHERAPIES. THE MOST PROMISING RESULTS HAD BEEN ACHIEVED WHEN COMBINING ANTI-PD-L1/PD-1 WITH TREATMENTS THAT ACTIVATE IMMUNE FUNCTION. WE PROPOSE THAT EXOGENOUS CARBON MONOXIDE (COEX) APPLIED AT LOW NON-TOXIC DOSES IS A POTENTIAL ADJUVANT FOR PATIENTS WITH LUNG CANCER TREATED WITH IMMUNOTHERAPY. CO IS GENERATED ENDOGENOUSLY BY HEME OXYGENASE-1 (HO-1) THAT ACTS DURING HOMEOSTASIS TO BREAK DOWN HEME TO THREE ACTIVE METABOLITES. WE HAVE DEMONSTRATED THAT COEX APPLIED AT 250 PPM FOR 1 HOUR PER DAY (THAT CORRESPONDS TO THE DOSE OF CO OBTAINED FROM BURNING 2 CIGARETTES) BLOCKS PROGRESSION OF LUNG AND PROSTATE CANCERS. COEX CAN BLOCK TUMOR GROWTH VIA TARGETING METABOLISM OF CANCER CELLS. HOWEVER, SINCE COEX BLOCKS GROWTH OF DIFFERENT TUMOR TYPES AND AT VARIOUS METABOLIC RATES AS WELL AS IS MORE EFFICIENT IN VIVO THAN IN VITRO IN INDUCING APOPTOSIS OF CANCER CELLS, WE REASONED COEX HAS A BROADER EFFECT IN THE TME THAT INCLUDES IMMUNE CELLS. OUR PRELIMINARY DATA SUGGEST THAT COEX PROMOTES MORE ‘IMMUNO-RECEPTIVE’ TUMOR MICROENVIRONMENT (TME). WE PROPOSE THAT REPROGRAMING OF THE TME BY REGULATING HEME METABOLISM REGULATES RESPONSES TO IMMUNOTHERAPY. OUR AIM IS TO: TO DETERMINE THE ROLE OF COEX IN REDIRECTING IMMUNE RESPONSES TO INCREASE EFFICACY OF IMMUNOTHERAPY. SPECIFICALLY, WE INTENT TO: I) DETERMINE EFFECTIVENESS OF THE COMBINATION OF COEX AND ANTI-CTLA-4, ANTI-PD-L1 OR ANTI-PD-1 TREATMENT IN A MOUSE MODEL OF LUNG CANCER. II) DETERMINE COEX-MEDIATED INDUCTION OF CD86 VIA MTOR-NOTCH1 SIGNALING DURING RESPONSE TO IMMUNOTHERAPY IN THE LUNG CANCER MODEL. III) DEFINE THE IMPORTANCE OF ENDOGENOUS HO-1-DERIVED CO DURING RESPONSE TO IMMUNOTHERAPY. THE INVESTIGATIONS PROPOSED IN THIS APPLICATION WILL DELINEATE THE ROLE OF CO AND HO-1 IN ACTIVATION OF THE HOST IMMUNE RESPONSES VIA SELECTIVE SIGNALING PATHWAYS LEADING TO INCREASE IN MYELOID FUNCTION IN THE TME. OUR FINDINGS WILL HAVE FUNDAMENTAL AND THERAPEUTIC IMPLICATIONS FOR PATIENTS WITH LUNG CANCER, ESPECIALLY THAT COEX IS IN CLINICAL TRIALS. THIS STUDY IS WELL-ALIGNED WITH THE MISSION OF THE NCI AND THIS RFA “NCI CLINICAL AND TRANSLATIONAL EXPLORATORY/DEVELOPMENTAL STUDIES (R21 CLINICAL TRIAL OPTIONAL)” (PAR-19-356).

LEAN DEMO

DISCUSSIONS OF PROGNOSIS AND STOPPING CANCER SCREENING IN OLDER ADULTS

EXPLOITATION OF PD1-MEDIATED TOLEROGENIC SIGNALS FOR THE TREATMENT OF SLE

MECHANISMS UNDERLYING DIABETIC SKELETAL FRAGILITY

DIRECTED PURINERGIC SIGNALING AS IMMUNOTHERAPY IN LEUKEMIA

IDENTIFICATION OF PLASMA- AND EXOSOME-BASED PROTEIN BIOMARKERS FOR EARLY DETECTION OF PANCREATIC CANCER USING SOMASCAN TECHNOLOGY

THE SEXUAL ASSAULT SERVICES CULTURALLY SPECIFIC PROGRAM (SAS CULTURALLY SPECIFIC PROGRAM) WAS CREATED BY THE VIOLENCE AGAINST WOMEN AND DEPARTMENT OF JUSTICE REAUTHORIZATION ACT OF 2005 (VAWA 2005), 34 U.S.C. 12511(C), AND IS PART OF THE FIRST FEDERAL FUNDING STREAM SOLELY DEDICATED TO THE PROVISION OF DIRECT INTERVENTION AND RELATED ASSISTANCE FOR VICTIMS OF SEXUAL ASSAULT. INTERVENTION AND RELATED ASSISTANCE INCLUDE ADVOCACY, ACCOMPANIMENT (E.G., ACCOMPANYING VICTIMS TO COURT, MEDICAL FACILITIES, POLICE DEPARTMENTS, ETC.), CRISIS INTERVENTION AND SUPPORT SERVICES, AND REFERRALS, AMONG OTHER SERVICES. UNDER THIS PROGRAM, SUCH SERVICES MAY BE PROVIDED TO ADULT, YOUTH, AND CHILD VICTIMS OF SEXUAL ASSAULT, FAMILY AND HOUSEHOLD MEMBERS OF SUCH VICTIMS, AND THOSE COLLATERALLY AFFECTED BY THE VICTIMIZATION. SURVIVORS OF SEXUAL ASSAULT FROM CULTURALLY SPECIFIC COMMUNITIES FREQUENTLY CONFRONT UNIQUE CHALLENGES WHEN SEEKING ASSISTANCE, SUCH AS LINGUISTIC AND CULTURAL BARRIERS. CULTURALLY SPECIFIC COMMUNITY-BASED ORGANIZATIONS ARE MORE LIKELY TO UNDERSTAND THESE CHALLENGES BECAUSE THEY ARE FAMILIAR WITH THE CULTURE, LANGUAGE, AND BACKGROUND OF VICTIMS FROM THEIR COMMUNITIES, WHO IN TURN ARE MORE INCLINED TO SEEK SERVICES FROM SUCH ORGANIZATIONS. THE GOAL OF THE SAS CULTURALLY SPECIFIC PROGRAM IS TO ESTABLISH, MAINTAIN, AND EXPAND CULTURALLY SPECIFIC INTERVENTION AND RELATED ASSISTANCE FOR VICTIMS OF SEXUAL ASSAULT, WHICH SERVE A VITAL ROLE IN PROVIDING SERVICES THAT ARE RELEVANT FOR THEIR COMMUNITIES.

THE GRANTS TO ENHANCE CULTURALLY SPECIFIC SERVICES FOR VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING PROGRAM IS AUTHORIZED BY 34 U.S.C. § 20124. THIS PROGRAM SUPPORTS THE MAINTENANCE AND REPLICATION OF EXISTING SUCCESSFUL COMMUNITY-BASED PROGRAMS PROVIDING CULTURALLY SPECIFIC SERVICES TO VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING, AS WELL AS THE DEVELOPMENT OF INNOVATIVE CULTURALLY SPECIFIC STRATEGIES TO ENHANCE ACCESS TO SERVICES AND RESOURCES FOR VICTIMS WHO FACE OBSTACLES TO USING MORE TRADITIONAL PROGRAMS.  CULTURALLY SPECIFIC SERVICES MEANS COMMUNITY-BASED SERVICES THAT INCLUDE CULTURALLY RELEVANT AND LINGUISTICALLY SPECIFIC SERVICES AND RESOURCES TO CULTURALLY SPECIFIC COMMUNITIES WHICH ARE STATUTORILY DEFINED AS “AMERICAN INDIANS (INCLUDING ALASKA NATIVES, ESKIMOS, AND ALEUTS); ASIAN AMERICANS; NATIVE HAWAIIANS AND OTHER PACIFIC ISLANDERS; BLACKS; AND HISPANICS.”  PROJECTS MUST: 1) WORK WITH STATE AND LOCAL GOVERNMENTS AND SOCIAL SERVICE AGENCIES TO DEVELOP AND ENHANCE EFFECTIVE STRATEGIES TO PROVIDE CULTURALLY SPECIFIC VICTIM SERVICES ; 2) INCREASE COMMUNITIES’ CAPACITY TO PROVIDE CULTURALLY SPECIFIC RESOURCES AND SUPPORT FOR VICTIMS AND THEIR FAMILIES; 3) STRENGTHEN CRIMINAL JUSTICE INTERVENTIONS BY PROVIDING TRAINING FOR LAW ENFORCEMENT, PROSECUTION, COURTS, PROBATION, AND CORRECTIONAL FACILITIES ON CULTURALLY SPECIFIC RESPONSES; 4) ENHANCE TRADITIONAL SERVICES TO VICTIMS THROUGH THE LEADERSHIP OF CULTURALLY SPECIFIC VICTIM SERVICES PROGRAMS ; 5) WORK IN COOPERATION WITH THE COMMUNITY TO DEVELOP EDUCATION AND PREVENTION STRATEGIES HIGHLIGHTING CULTURALLY SPECIFIC ISSUES AND RESOURCES; 6) PROVIDE CULTURALLY SPECIFIC PROGRAMS FOR CHILDREN EXPOSED TO DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING; 7) PROVIDE CULTURALLY SPECIFIC RESOURCES AND SERVICES THAT ADDRESS THE SAFETY, ECONOMIC, HOUSING, AND WORKPLACE NEEDS OF VICTIMS, INCLUDING EMERGENCY ASSISTANCE; AND/OR 8) EXAMINE THE DYNAMICS OF CULTURE AND ITS IMPACT ON VICTIMIZATION AND HEALING. THE TIMING FOR PERFORMANCE OF THIS AWARD IS 24 MONTHS.

EMERG SHELTER GRANTS

EMERG SHELTER GRANTS

MECHANISMS OF RESISTANCE TO ANDROGEN DEPRIVATION THERAPY IN ADVANCED CASTRATION-RESISTANT PROSTATE CANCER (CRPC)

EXTRACELLULAR VESICLES IN ALCOHOLIC LIVER DISEASE: BASIC AND PRE-CLINICAL DISCOVERY

ESTABLISHING MECHANISTIC EFFECTS OF FSGS-CAUSING GENETIC MUTATIONS IN A COCULTURE GLOMERULAR TISSUE MODEL

CENTRAL REGULATION OF SODIUM APPETITE VIA SYNERGISTIC ACTION OF RAAS-SENSITIVE NEURONS

ADVOCATING FOR YOUTH IN THE MS DELTA

HOMELESS ASSISTANCE

HOMELESS ASSISTANCE

HOMELESS ASSISTANCE

HOMELESS ASSISTANCE

PROTEOMIC ANALYSIS OF POSTOPERATIVE DELIRIUM FROM A RANDOMIZED TRIAL IN OLDER PATIENTS UNDERGOING CARDIAC SURGERY EXPOSED TO INTRAOPERATIVE NORMOXIA VERSUS HYPEROXIA: A NESTED CASE-CONTROL STUDY

THE EFFECTS OF THE DASH DIET AND SODIUM REDUCTION ON SUBCLINICAL CARDIAC DAMAGE

HOMELESS ASSISTANCE

CARDIOPULMONARY MANIFESTATIONS AND TRANSLATIONAL POTENTIAL OF A NOVEL RADIOGRAPHIC BIOMARKER OF PULMONARY VASCULAR MORPHOLOGY

SYNAPTIC MECHANISMS OF INTERNEURON TRANSPLANT INDUCED PLASTICITY

EDI SPECIAL PROJECTS

TRENDS, PRACTICE VARIATIONS, AND OUTCOMES OF GASTROSTOMY TUBES PLACED DURING CRITICAL ILLNESS IN THE UNITED STATES

HOSPITALIZATION FOR ALCOHOL WITHDRAWAL SYNDROME: BURDEN AND TREATMENT