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NEURO-EXERGAMING FOR THE PREVENTION AND REMEDIATION OF DECLINE DUE TO PARKINSON'S DISEASE: CLINICAL TRIAL OF THE INTERACTIVE PHYSICAL AND COGNITIVE EXERCISE SYSTEM (IPACES V3) - PROJECT SUMMARY/ABSTRACT PARKINSON’S DISEASE (PD) IS THE SECOND MOST PREVALENT NEURODEGENERATIVE DISORDER AFTER ALZHEIMER’S DISEASE WITH PREVALENCE ESTIMATED AT 0.3% IN THE GENERAL POPULATION AND AT 1% IN INDIVIDUALS OVER AGE 60 (GETZ & LEVIN, 2017). IN ADDITION TO THE CARDINAL MOTOR FEATURES ASSOCIATED WITH THIS ILLNESS, INDIVIDUALS WITH PD ALSO EXPERIENCE COGNITIVE DECLINE. WHILE ESTIMATES VARY (GOLDMAN ET AL, 2013), IT IS ESTIMATED THAT UP TO 40% OF PD PATIENTS WOULD MEET CRITERIA FOR A DIAGNOSIS OF MILD COGNITIVE IMPAIRMENT AND THAT UP TO 80% WILL DEVELOP DEMENTIA OVER THE COURSE OF THE DISEASE (KENNEY ET AL, 2022). GIVEN LIMITATIONS IN CURRENT TREATMENTS FOR PD AND THE LACK OF A COMPLETE CURE, THERE IS AN OUTCRY FOR ADDITIONAL RESEARCH INTO EFFECTIVE INTERVENTIONS, PARTICULARLY THOSE THAT MIGHT SLOW COGNITIVE DECLINE AS WELL AS CONVERSION TO DEMENTIA (CAMMISULI ET AL, 2019). AT PRESENT, WHILE DOPAMINERGIC MEDICATIONS AND SURGICAL INTERVENTIONS (DBS) OFTEN AMELIORATE SOME MOTORIC SYMPTOMS (AT LEAST TEMPORARILY), THERE IS MINIMAL DOCUMENTED NEUROPSYCHOLOGICAL BENEFIT. AS RESULT, THERE HAS BEEN A CALL FOR LIFESTYLE INTERVENTIONS FOR OLDER ADULTS TO PREVENT, DELAY OR AMELIORATE COGNITIVE DECLINE VIA NON-PHARMACOLOGICAL INTERVENTIONS SUCH AS EXERCISE (CAMISUL ET AL, 2019). OUR INITIAL RANDOMIZED CONTROLLED TRIAL (RCT) INVESTIGATED EXERGAMING FOR OLDER ADULTS (ANDERSON-HANLEY ET AL., 2012A), AND REVEALED SIGNIFICANT COGNITIVE BENEFIT AFTER THREE MONTHS OF PEDALING A VIRTUAL REALITY ENHANCED BIKE OR “CYBERCYCLE,” COMPARED WITH TRADITIONAL PEDALING ONLY. RESULTS SUGGEST THAT FOR THE SAME EFFORT, INTERACTIVE PHYSICAL AND MENTAL EXERCISE ON A CYBERCYCLE CAN YIELD GREATER COGNITIVE BENEFIT THAN PHYSICAL EXERCISE ALONE ON A STATIONARY BIKE. FURTHERMORE, THERE WAS A 23% REDUCTION IN RISK OF CONVERSION TO MCI AMONG THE CYBERCYCLISTS. THE PI AND COLLABORATORS HAVE WORKED TO REPLICATE AND EXTEND THIS LINE OF RESEARCH WITH PATIENTS WITH VARIED NEUROLOGICAL CONDITIONS WHICH SPARKED DEVELOPMENT OF A PORTABLE, AFFORDABLE TABLET-BASED PROTOTYPE: THE INTERACTIVE PHYSICAL AND COGNITIVE EXERCISE SYSTEM (IPACES) WHICH CAN BE PAIRED WITH AN UNDER-TABLE ELLIPTICAL PEDALER FOR IN-HOME USE. DATA FROM IN-HOME PILOT TRIALS (V1 & V2), FOUND EXECUTIVE FUNCTION SIGNIFICANTLY IMPROVED AFTER 3-MONTHS OF PEDALING-TO-PLAY IN THE IPACES NEURO-EXERGAME, AND MORE SO THAN GAME-ONLY (ANDERSON-HANLEY ET AL., 2018B; WALL ET AL., 2018). THE PROPOSED RESEARCH AIMS TO REPLICATE AND EXTEND THESE FINDINGS IN PARKINSON’S. IF WARRANTED BY THE DATA, WE WILL PURSUE THE GOAL OF OFFERING TO PATIENTS, FAMILIES, AND HEALTHCARE PROVIDERS AN ADDITIONAL TOOL FOR PD PATIENTS AND CAREGIVERS TO PRESERVE BRAIN HEALTH AND CURB COGNITIVE DECLINE, ALL IN THE FIGHT AGAINST DEMENTIA.

NEURO-EXERGAMING FOR THE PREVENTION AND REMEDIATION OF DECLINE DUE TO ALZHEIMER'S DISEASE AND RELATED DEMENTIAS: A CLINICAL TRIAL OF THE INTERACTIVE PHYSICAL AND COGNITIVE EXERCISE SYSTEM (IPACES V3)

ARRA - TRAINING IN PRIMARY CARE MEDICINE AND DENTISTRY: RESIDENCY TRAINING IN PRIMARY CARE

PREVENTIVE MEDICINE RESIDENCIES

PREVENTIVE MEDICINE RESIDENCIES

PRIMARY CARE TRAINING AND ENHANCEMENT

PREVENTIVE MEDICINE RESIDENCY

ARRA - PREVENTIVE MEDICINE RESIDENCY PROGRAM

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

PREVENTIVE MEDICINE RESIDENCIES

TO PROVIDE SUPPORT FOR A PROGRAM IN RESPONSIBLE SOURCING PARTNERSHIP

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** A PRESCRIPTION FOR HEALTH EQUITY: A HEALTHCARE PROVIDER-BASED PRODUCE PRESCRIPTION PROGRAM FOR PEOPLE WITH PRE-DIABETES AND TYPE 2 DIABETES

CENTRAL AFRCA FOREST MONITORING

CONGO BASIN FOREST MONITORING

PREVENTIVE MEDICINE RESIDENCIES

HEALTH CARE AND OTHER FACILITIES

HEALTH CARE AND OTHER FACILITIES

FIXED OBLIGATION GRANT

ARRA - EQUIPMENT TO ENHANCE TRAINING FOR HEALTH PROFESSIONALS

PRIMARY CARE TRAINING AND ENHANCEMENT

HEALTH CARE AND OTHER FACILITIES

THE PROVIDENCE COMMUNITY BASKETBALL LEAGUE, MANAGED BY THE GREATER PROVIDENCE YMCA, AIMS TO REDUCE CRIME AND PROMOTE POSITIVE COMMUNITY ENGAGEMENTAMONG AT-RISK YOUNG ADULTS THROUGH ORGANIZED SPORTS ACTIVITIES. INSPIRED BY THE SUCCESSFUL MIDNIGHT BASKETBALL LEAGUE, THIS PROGRAM PROVIDES A STRUCTURED ENVIRONMENT DURING PEAK TIMES OF YOUTH-RELATED DISTURBANCES. PARTNERING WITH LOCAL LAW ENFORCEMENT AND COMMUNITY ORGANIZATIONS, THE PROGRAM OFFERS BASKETBALL GAMES AND LIFE SKILLS WORKSHOPS TO PARTICIPANTS, TARGETING KEY ISSUES SUCH AS DRUG USE, GANG INVOLVEMENT, AND STRAINED POLICE-COMMUNITY RELATIONS. THROUGH QUALITATIVE AND QUANTITATIVE METHODS, THE PROJECTS IMPACT WILL BE MEASURED BY EVALUATING CHANGES IN PARTICIPANTS' BEHAVIOR AND ENGAGEMENT LEVELS. THE INITIATIVE SEEKS TO PROVIDE A SENSE OF COMMUNITY OWNERSHIP, ENHANCE COMMUNITY-POLICE RELATIONS, AND ULTIMATELY GUIDE YOUNG ADULTS TOWARD POSITIVE LIFE CHOICES AND ACADEMIC SUCCESS.

CELL-FREE PROTEIN SYNTHESIS (CFPS) DEVICES WITH HIGH-YIELD FOR SYNTHETIC BIOLOGY

SUSTAINABLE SOURCING PARTNERSHIP

INTEGRATIVE MEDICINE PROGRAM

ASSISTANCE TO FIREFIGHTERS GRANT

TO MANAGE THE AMERICAN CENTRE OPERATIONS AND PUBLIC DIPLOMACY SECTION (PDS) PROGRAMMING AT THE CENTER FOR A PERIOD OF 24 MONTHS, FROM OCTOBER 2, 2023, TO SEPTEMBER 30, 2025.

TO MANAGE THE AMERICAN CENTER OPERATIONS AND PROVIDE INNOVATIVE OUTREACH PROGRAMMING TO EXISTING AND NEW AUDIENCES IN LINE WITH THE U.S. MISSION GOAL

MANAGE THE AMERICAN CENTRE OPERATIONS AND PUBLIC AFFAIRS SECTION (PAS) PROGRAMMING AT THE CENTRE FOR A PERIOD OF 12 MONTHS, STARTING SEPTEMBER 30, 2022 TO SEPTEMBER 29, 2023.

THIS PROPOSAL FOCUSES ON THE CONTINUATION OF THE CORE PROGRAMMING AREAS WHICH INCLUDE AMERICAN CULTURE AND VALUES EDUCATION USA STEM PROMOTION FOR GIRLS AND YOUNG WOMEN THE POWER OF CREATIVITY ENTREPRENEURSHIP/ECONOMIC EMPOWERMENT

TO ENHANCE THE EFFECTIVENESS OF AMERICAN CENTER PROGRAMMING BY ENSURING STRONG HUMAN RESOURCE MANAGEMENT AND OPERATIONAL SUPPORT AS THE EMBASSY'S PRIMARY PROGRAMMING SPACE FOR AMERICA 250.

TO COVER RENT, FURNISHING, AND DESIGN COSTS FOR THE AMERICAN CENTER TO ENSURE CONTINUOUS PROGRAMMING AND MANAGEMENT FOR A PERIOD OF 12 MONTHS, FROM MAY 1, 2023, TO FEBRUARY 29, 2024.

TO MANAGE THE AMERICAN CENTER OPERATIONS AND PROGRAMMING FOR ONE YEAR.

AFFORDABLE CARE ACT (ACA) GRANTS FOR SCHOOL-BASED HEALTH CENTERS CAPITAL PROGRAM

COMMUNITY FACILITY GRANTS

#1072233V154 -OVERSEE THE EDUCATIONUSA ADVISORY FUNCTION AT THE AMERICAN CENTER

TO HIRE A FULL TIME EDUCATIONUSA ADVISOR FOR A PERIOD OF 12 MONTHS.

REDESIGN THE OVERALL LOOK OF THE AMERICAN CENTER, AND AID VISIBILITY THROUGH BRANDING AND MULTIMEDIA PROMOTION IN COLLABORATION WITH THE PUBLIC DIPLOMACY SECTION FOR A PERIOD OF 12 MONTHS, FROM OCTOBER 1, 2024, TO SEPTEMBER 30, 2025.

MANAGE THE PLANNING, LOGISTICS, AND DELIVERY OF THE WORLD101 COURSE ON U.S FOREIGN POLICY, TO 100 SELECTED UGANDAN PARTICIPANTS INCLUDING JOURNALISTS, CIVIL SOCIETY LEADERS, GOVERNMENT OFFICIALS, POLICY ANALYSTS AND ACADEMIA.

IMPLEMENT A STEM AND SOFT SKILLS TRAINING PROGRAM TARGETING OVER 200 YOUNG WOMEN AND MEN AGED BETWEEN 19 AND 24, IN ORDER TO ENCOURAGE THEM PURSUE STEM CAREER OPPORTUNITIES, AND ALSO EQUIP THEM WITH LIFE SKILLS.

1072244V199-OVERSEE THE EDUCATIONUSA ADVISORY FUNCTION AND MANAGEMENT OF THE OPPORTUNITY FUND PROGRAM THROUGH THE AMERICAN CENTER FOR A PERIOD OF 12 MONTHS, STARTING JULY 1, 2024, TO JUNE 30, 2025

THIS GRANT SUPPORTS THE COSTS INCURRED TO IMPLEMENT MEASURES TO RESPOND TO THE NOVEL CORONAVIRUS 2019 (COVID-19), WHICH MAY INCLUDE WORKPLACE SAFETY, MARKET PIVOTS, RETROFITTING FACILITIES, TRANSPORTATION, WORKER HOUSING, AND MEDICAL EXPENSES. IT PROVIDES NEEDED RELIEF TO THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS FOR THEIR COSTS INCURRED BETWEEN JANUARY 27, 2020, THE DATE UPON WHICH THE PUBLIC HEALTH EMERGENCY WAS DECLARED BY THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICE (HHS) UNDER SECTION 319 OF THE PUBLIC HEALTH SERVICE ACT, AND DECEMBER 31, 2021. BENEFICIARIES INCLUDE THE EMPLOYEES OF THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS.

A00322M5033-TO RECENTER FACTS ABOUT THE RUSSIAN-UKRAINIAN WAR AMONG UGANDA'S OPINION LEADERS.

OVERSEE THE EDUCATION USA ADVISORY FUNCTION AND MANAGEMENT OF THE OPPORTUNITY FUND PROGRAM THROUGH THE AMERICAN CENTER

PREVENTIVE MEDICINE RESIDENCIES

PREVENTIVE MEDICINE RESIDENCIES