Resonance

AUTOMATIC QUANTIFICATION AND LABELING OF CEREBRAL MICROBLEEDS, OXYGEN SATURATION AND SOURCES OF ABNORMAL SUSCEPTIBILITY

SUSCEPTIBILITY WEIGHTED IMAGING (SWI)

DEVELOPMENT OF FLOW AND VASCULAR QUANTIFICATION SOFTWARE FOR THE ASSESSMENT OF MR

BEYOND VIOLENCE PROGRAM

PULSED ESR OXYGEN IMAGING SYSTEM (ESROI) - PROJECT SUMMARY THE AIM OF THIS PROPOSAL IS TO SUPPORT THE PURCHASE OF AN ADVANCED PULSE ELECTRON SPIN RESONANCE OXYGEN IMAGER (ESROI), ALSO KNOWN AS ELECTRON PARAMAGNETIC RESONANCE OXYGEN IMAGER (EPROI), AT CORNELL UNIVERSITY. IT WILL BE INSTALLED AT THE CORNELL MAGNETIC RESONANCE IMAGING FACILITY (CMRIF) AND ADMINISTRATED BY THE NATIONAL RESOURCE FOR ADVANCED ELECTRON SPIN RESONANCE SPECTROSCOPY (ACERT), WHICH IS FUNDED BY THE NIGMS R24 AWARD. THE ESROI SYSTEM REQUESTED IS THE ONLY COMMERCIALLY AVAILABLE ESR-BASED OXYGEN IMAGER AND WOULD BE THE FIRST ONE IN THE NORTHEAST UNITED STATES. IT ENABLES FAST, NON-INVASIVE AND ACCURATE 3D PARTIAL PRESSION OF OXYGEN (PO2) MAPPING IN HIGH SPATIAL AND TEMPORAL RESOLUTIONS ACROSS A WIDE RANGE OF SAMPLE TYPES, INCLUDING IN VITRO, IN VIVO AND EX VIVO APPLICATIONS. THERE IS A SUBSTANTIAL AND GROWING DEMAND FOR SUCH OXYGEN IMAGING CAPACITIES, AS THEY PROVIDE CRITICAL SPATIAL AND TEMPORAL INFORMATION ABOUT TISSUE OXYGENATION. THE DATA IS HIGHLY RELEVANT TO NUMEROUS BIOMEDICAL, PHYSIOLOGICAL, PATHOLOGICAL CONDITIONS, INCLUDING HYPOXIA, TUMOR, INJURY RECOVERY AND DEMENTIA. THE ESROI SYSTEM WILL BE USED BY RESEARCH GROUPS AT CORNELL, UPSTATE NEW YORK, GREATER NEW YORK CITY AND ACROSS THE NORTHEAST REGION. THE NIH-FUNDED RESEARCH PROJECTS OF THE MAJOR USERS INCLUDE: (1) MITOCHONDRIAL (DYS)FUNCTION IN ARTICULAR CARTILAGE HEALTH, DISEASE AND REGENERATION; (2) NON- INVASIVE, IN VIVO MEASUREMENT OF TISSUE OXYGEN IN ACUTE CARDIOPULMONARY DISEASES; (3) ISLET FUNCTION UPON TRANSPLANTATION; (4) IMAGE-GUIDED LIGHT DOSIMETRY IN INTERSTITIAL PHOTODYNAMIC THERAPY (I-PDT) FOR THE TREATMENT OF LOCALLY ADVANCED CANCER REFRACTORY TO CURRENT STANDARD OF CARE THERAPIES; AND (5) MITOCHONDRIAL DYSFUNCTION IN OSTEOLINEAGE CELLS DURING AGING. ADDITIONAL PROJECTS FROM MINOR USERS INCLUDES: (6) SPATIALLY FRACTIONATED RADIOTHERAPY (SFRT) IN OSTEOSARCOMA; (7) ESROI IN PLANT SCIENCES: ROOT-ZONE OXYGEN DYNAMICS IN LETTUCE; (8) MITOCHONDRIAL DYSFUNCTION IN THE BRAIN DURING NEURODEGENERATION OF ALZHEIMER’S DISEASE; (9) 3D OXYGEN IMAGING OF ENTHESIS REPAIR IN ROTATOR CUFF AND ACL INJURY MODELS; AND (10) OXYGEN DYNAMICS AND MITOCHONDRIAL FUNCTION DURING THE POST-CARDIAC ARREST PERIOD. ACERT IS THE ONLY NATIONAL RESOURCE IN THE UNITED STATES DEDICATED TO ESR RESEARCH AND HAS A LONG-STANDING TRADITION OF LEADERSHIP IN DEVELOPING AND PROMOTING ESR TECHNOLOGIES, INCLUDING ESR IMAGING. HOWEVER, ACERT CURRENTLY LACKS IMAGING CAPABILITIES FOR LARGE BIOLOGICAL SPECIMENS—REPRESENTING THE LAST MAJOR ESR MODALITY NOT YET AVAILABLE AT THE CENTER. ACERT’S STRATEGIC LOCATION, ROBUST INFRASTRUCTURE, PROVEN HISTORY OF TECHNOLOGICAL INNOVATION, AND WELL-ESTABLISHED SYSTEMS FOR TICKETING, RESERVATIONS, AND SERVICE TRACKING, COMBINED WITH A STRONG ADMINISTRATIVE AND OUTREACH TEAM, ENSURE EFFECTIVE OPERATION AND MAINTENANCE OF NEW TECHNOLOGIES. MOST IMPORTANTLY, ITS UNWAVERING COMMITMENT TO USER SUPPORT—INCLUDING A FREE-ACCESS POLICY FOR ACADEMIC USERS—POSITIONS ACERT TO SUCCESSFULLY IMPLEMENT, PROMOTE, AND EXPAND THE USE OF THE ESROI SYSTEM.

OPTIMIZED CROP IRRIGATION USING A COST-EFFECTIVE IN-SITU NMR SOIL WATER PROBE

FULLY COMPENSATED DYNAMIC SHIM SYSTEM FOR IN VIVO MRI AND MRS

FULLY COMPENSATED DYNAMIC SHIM SYSTEM FOR IN VIVO MRI AND MRS

DYNAMIC HIGH-ORDER SHIM SYSTEM FOR IMPROVED NEURO-MRI - ABSTRACT THE PURPOSE OF THIS PROPOSAL TO DEMONSTRATE THE FEASIBILITY OF BUILDING A PRACTICAL SHIM SUB-SYSTEM BASED ON A MINIMALLY INTERACTING IN-BORE SHIM COIL USING A HIGHLY CONTROLLABLE POWER ARRAY FOR USE IN COMMERCIAL MRI SCANNERS FOR MULTI-BAND NEUROIMAGING AND SPECTROSCOPY APPLICATIONS AT HIGH FIELDS. OVER THE PAST SEVERAL YEARS, THE IMPORTANCE OF IMPROVED B0 SHIMMING FOR ECHO PLANAR IMAGING (EPI) HAS BEEN RECOGNIZED BY SEVERAL GROUPS. TECHNICAL DEVELOPMENTS HAVE FOCUSED ON WAYS OF PROVIDING HIGHER SPATIAL FREQUENCY CORRECTIONS AND HIGHER STRENGTH OF LOCAL B0 CORRECTIONS. TWO METHODS OF ACCOMPLISHING THOSE GOALS WERE APPLIED: 1) MULTI-COIL (MC) ARRAYS FREQUENTLY UTILIZING DC-COUPLED RF COILS OR 2) VERY-HIGH ORDER SHIM (VHOS) INSERTS BASED ON SPHERICAL HARMONIC (SH) SYMMETRIES. ALSO, FOR THE HUMAN BRAIN, OPTIMIZING THE B0 SHIM CORRECTIONS ON A SLICE-BY-SLICE (SBS) BASIS WAS DEMONSTRATED TO SIGNIFICANTLY IMPROVE HOMOGENEITY. BECAUSE OF THIS, SEVERAL GROUPS HAVE DEVELOPED DYNAMIC UPDATING APPROACHES, INCLUDING STRATEGIES TO MITIGATE ARTIFACTS DUE TO EDDY-CURRENT EFFECTS ASSOCIATED WITH DYNAMIC SHIM UPDATING (DSU). IT HAS BEEN DEMONSTRATED THAT THE USE OF VHOS INSERTS BASED ON 4TH ORDER SH CAN PROVIDE SUPERIOR SHIM PERFORMANCE TO SPARSE MC ARRAYS FOR BOTH STATIC AND DYNAMIC SHIMMING. IT HAS ALSO BEEN DEMONSTRATED THAT THEORETICALLY AND EXPERIMENTALLY VHOS INSERTS CAN ACHIEVE MB=2 WITH EQUIVALENT HOMOGENEITY TO SBS WITH SIGNIFICANT GAINS OVER WHOLE BRAIN SHIMMING MAINTAINED UP TO MB=4. THUS, A NEW VHOS INSERT TECHNOLOGY CAPABLE OF DISTINCT CORRECTIONS AT UP TO 3 OR 4 SPATIALLY DISPARATE SLICE LOCATIONS SIMULTANEOUSLY WITH EQUIVALENT PERFORMANCE TO SBS SHIMMING ENABLED BY DSU TECHNOLOGY WILL GREATLY IMPROVE PERFORMANCE OF MB EPI AND OTHER SENSITIVE TECHNIQUES. TO ACHIEVE THE GOAL OF UP TO MB=4 WE WILL LEVERAGE OUR RECENT WORK ON SECOND GENERATION 7T SCANNERS. THE GOAL OF THIS PHASE I PROPOSAL IS TO DEMONSTRATE AN OPTIMIZED PROTOTYPE OF EASILY INSTALLABLE DIGITALLY CONTROLLED, REAL-TIME MULTIBAND SHIMMING SYSTEM FOR SIEMENS TERRA 7T IMPLEMENTATION WITH COMMERCIALIZATION IN PHASE II.

SBIR PHASE I: INQR: A LOW-COST, SMART, PORTABLE SPECTROSCOPY DEVICE FOR MATERIAL AUTHENTICATION -THIS SMALL BUSINESS INNOVATION RESEARCH PHASE I PROJECT AIMS TO DEVELOP AND COMMERCIALIZE A HANDHELD AUTHENTICATION DEVICE, BASED ON THE PRINCIPLE OF NUCLEAR QUADRUPOLE RESONANCE (NQR) SPECTROSCOPY, THAT CAN HELP IMPROVE THE HEALTH AND SAFETY OF THE GENERAL PUBLIC. THE PORTABLE FORM FACTOR AND LOW COST OF THE DEVICE WILL MAKE IT ACCESSIBLE FOR EVERYONE TO UTILIZE WITHOUT ANY RESTRICTIONS. THE POWERFUL ANALYTICAL CAPABILITY OF THIS DEVICE TO PROVIDE ACCURATE AND RELIABLE RESULTS QUICKLY AND NON-INVASIVELY CAN BE USED IN DIFFERENT STAGES OF THE MODERN SUPPLY CHAIN. SPECIFIC USE CASES OF THE DEVICE WILL INCLUDE THE LAW-ENFORCEMENT AGENCIES AND POSTAL SYSTEMS, WHERE IT CAN BE USED TO RAPIDLY IDENTIFY AND ISOLATE ILLEGAL DRUGS, THEREBY MITIGATING THE ILLEGAL DRUG EPIDEMIC. IN ADDITION TO ITS USE IN LAW ENFORCEMENT AND FORENSICS, THIS SPECTROSCOPY TECHNOLOGY HAS POTENTIAL APPLICATIONS IN THE MEDICAL FIELD FOR DRUG SCREENING AND MONITORING. ITS APPLICABILITY IN DRUG AND PHARMACEUTICAL PRODUCTS DETECTION ALONE WILL IMPACT A MULTI-BILLION-DOLLAR MARKET. OVERALL, THIS INNOVATION WILL GREATLY ENHANCE OUR SCIENTIFIC AND TECHNICAL UNDERSTANDING OF THE CAPABILITIES AND LIMITATIONS OF THE NQR SPECTROSCOPY TECHNOLOGY FOR CHEMICAL ANALYSIS AND CREATE A PATHWAY FOR ITS WIDESPREAD DEPLOYMENT IN DIVERSE FIELDS. THE INTELLECTUAL MERIT OF THIS PROJECT LIES IN UTILIZING NQR SPECTROSCOPY TO PROVIDE A HIGHLY SPECIFIC AND SENSITIVE METHOD AT LOW COST FOR DETECTING DRUGS BASED ON THEIR UNIQUE CHEMICAL IDENTIFIERS (UCIS). THE PROJECT WILL FOCUS ON DEVELOPING A PORTABLE NQR SPECTROMETER DEVICE FOR GENERAL CONSUMER USE TO DETECT AND IDENTIFY VARIOUS COMPOUNDS BASED ON THEIR UNIQUE CHEMICAL AND STRUCTURAL PROPERTIES IN THE SOLID STATE. NQR SPECTROSCOPY CAN DETECT DRUGS THAT MAY BE DIFFICULT TO IDENTIFY USING OTHER TECHNIQUES, SUCH AS THOSE THAT ARE HIGHLY PURE OR ARE CONCEALED IN COMPLEX MIXTURES OR DISGUISED AS OTHER SUBSTANCES. THE PROJECT WILL EXPLORE NEW APPROACHES TO IMPROVING THE SENSITIVITY BASED ON PRE-POLARIZATION METHODS, AS WELL AS SIZE, COST, AND SELECTIVITY OF NQR SPECTROSCOPY FOR DRUG DETECTION, AS WELL AS DEVELOPING NEW PORTABLE INSTRUMENTATION. MAJOR HARDWARE COMPONENTS, INCLUDING THE BROADBAND TUNER AND BACKEND SIGNAL PROCESSING UNIT, WILL BE CUSTOM DESIGNED TO MINIMIZE THE FOOTPRINT AND IMPROVE SENSITIVITY. THE DEVICE WILL BE EXTENSIVELY EVALUATED FOR WIDE RANGE OF DRUGS AND OTHER SUBSTANCES (E.G., DIETARY SUPPLEMENTS, WHICH OFTEN INCLUDE UNREGULATED HARMFUL CHEMICALS) FOR ITS EFFICACY IN COMMERCIAL SETTINGS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

DEVELOPMENT OF A NOVEL MOBILE APPLICATION TO ASSIST IN THE DIAGNOSIS OF FETAL ALCOHOL SYNDROME (FAS)

FULLY COMPENSATED DYNAMIC SHIM SYSTEM FOR IN VIVO MRI AND MRS

OPTIMIZATION OF HUMAN HEAD MRI AND MRS USING HIGH ORDER SHIM INSERT

OPTIMIZATION AND EXTENSION OF MRE FOR THE STUDY OF FORCE CHAIN STRUCTURE IN 3D GRANULAR MATERIALS

SBIR PHASE I: OVERHAUSER-ENHANCED MRI (OMRI) COMBINED WITH FIELD-CYCLING

OPTIMIZED CROP IRRIGATION USING A COST-EFFECTIVE IN-SITU NMR SOIL WATER PROBE

SCHOLARSHIP AND MENTORSHIP EXPANSION AT THE ANNUAL SCIENTIFIC SESSIONS OF THE SOCIETY OF CARDIOVASCULAR MAGNETICRESONANCE

PURPOSE: TO SUPPORT A CHORAL PERFORMANCE AND FESTIVAL COMMEMORATING JAPANESE AMERICAN INCARCERATION DURING WORLD WAR II. 

SCHOLARSHIP AND MENTORSHIP EXPANSION AT THE 21ST SCMR SCIENTIFIC SESSIONS

SCHOLARSHIP AND MENTORSHIP EXPANSION AT THE 20TH SCMR SCIENTIFIC SESSIONS

SCHOLARSHIP AND MENTORSHIP EXPANSION AT THE 19TH SCMR SCIENTIFIC SESSIONS