Federation Of American Societies For Experimental Biology

DIVERSITY RESOURCES FOR ENRICHMENT, ACCESS & MENTORING

LEADERSHIP, EXCELLENCE, AND DEVELOPMENT OF DIVERSITY IN RESEARCH

DIVERSITY RESOURCES FOR ENRICHMENT, ACCESS & MENTORING 2

A FEDERATION APPROACH FOR THE PROFESSIONAL DEVELOPMENT OF MOSAIC SCHOLARSIN THE BIOLOGICAL AND BIOMEDICAL SCIENCES - THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB) PROPOSES A MOSAIC PROGRAM THAT WILL PROVIDE DIVERSE SCHOLARS FROM HISTORICALLY EXCLUDED GROUPS IN BIOLOGICAL AND BIOMEDICAL RESEARCH WITH PROFESSIONAL SKILLS NEEDED TO ESTABLISH A SUCCESSFUL ACADEMIC CAREER, COUPLED WITH MENTORING, COHORT SUPPORT, NETWORK DEVELOPMENT, AND THE FOSTERING OF RESILIENCE. THIS SUPPORT WILL INCREASE SCHOLAR RETENTION IN ACADEMIC RESEARCH, THUS DIVERSIFYING THE BIOMEDICAL RESEARCH ENTERPRISE AND CONTRIBUTING TO LONG-TERM IMPROVEMENTS IN INCLUSIVE RESEARCH ENVIRONMENTS AT INSTITUTIONS AND WITHIN SCIENTIFIC SOCIETIES. IN TURN, THIS WILL LEAD TO ADVANCEMENTS IN HEALTH RESEARCH OUTCOMES DUE TO THE BENEFIT OF DIVERSE PERSPECTIVES BROUGHT TO THE EFFORT TO ADDRESS SCIENTIFIC CHALLENGES. FASEB HAS DEEP ORGANIZATIONAL EXPERIENCE IN PROVIDING SUPPORT TO EARLY-CAREER RESEARCHERS. THE PROJECT’S GOALS ARE TO PREPARE FIVE COHORTS OF DIVERSE EARLY-CAREER RESEARCHERS (POSTDOCS PROGRESSING TO INDEPENDENT FACULTY) IN RESEARCH TEAM MANAGEMENT AND PROVIDE SUPPORT THROUGH TRAINING, MENTORING, AND NETWORKING, LEADING TO THE MOSAIC SCHOLARS’ ABILITY TO PERSIST IN CAREER ADVANCEMENT WHILE MAINTAINING WELL-BEING THROUGH EMPOWERMENT AND RESILIENCE. SPECIFIC AIMS ARE TO (1) DEVELOP RESEARCH MANAGEMENT SKILL SETS IN DIVERSE POSTDOCTORAL AND EARLY-CAREER FACULTY RESEARCHERS BY LEVERAGING FASEB’S DEEP NETWORK OF EXPERTS AND MENTORS ACROSS SCIENTIFIC SOCIETIES, AS EVIDENCED BY SCHOLAR CAPABILITIES IN SETTING UP A LAB AND PROGRESSING IN RESEARCH; (2) DEVELOP RESILIENCE IN DIVERSE POSTDOCTORAL AND EARLY-CAREER FACULTY RESEARCHERS THROUGH IDENTITY DEVELOPMENT BASED ON COMPETENCE, PERFORMANCE, AND RECOGNITION, AS EVIDENCED BY INCREASED SCHOLAR CONFIDENCE TO OVERCOME BARRIERS AND ACHIEVE STAGE-APPROPRIATE RESEARCH CAREER PROGRESSION BOTH INSTITUTIONALLY AND THROUGH PROFESSIONAL SERVICE; AND (3) CREATE SUSTAINING SUPPORT SYSTEMS THAT INVOLVE SKILLS DEVELOPMENT, PEER SUPPORT, AND SAFE SPACES, AS EVIDENCED BY SCHOLAR PERCEPTIONS OF THE VALUE OF SUCH SUPPORT IN HELPING THEM PERSIST IN THEIR CAREER PATHWAY WHILE MAINTAINING RESILIENCE AND WELL-BEING. FASEB’S MOSAIC PROGRAM WILL IMPLEMENT A PROFESSIONAL DEVELOPMENT SERIES THAT COVERS SKILL SETS IMPORTANT FOR FACILITATING SCHOLAR CAREER PROGRESSION. THE SERIES COVERS FOUNDATIONAL SKILLS, PROFESSIONAL SKILLS, EFFECTIVE GRANT WRITING, AND ACADEMIC CAREER PLANNING OVER FOUR YEARS. RESILIENCE WILL BE COVERED IN A RESILIENCE AND SELF- ADVOCACY COURSE AND THROUGH VIRTUAL SUPPORT SPACES. IN A MULTI-MENTOR MODEL, THE SCHOLARS WILL BE MATCHED WITH A MENTOR IDENTIFIED THROUGH FASEB’S EXTENSIVE NETWORK TO COMPLEMENT THE MENTORING THEY RECEIVE THROUGH THEIR HOME INSTITUTIONS. MENTORING WILL COVER CAREER ISSUES, PROFESSIONAL MANAGEMENT, AND WORK-LIFE BALANCE AND WILL FOSTER THE DEVELOPMENT OF PROFESSIONAL NETWORKS. ADDITIONAL ACTIVITIES INCLUDE FINANCIAL SUPPORT FOR CONFERENCE ATTENDANCE; ENGAGEMENT OF LEADERS AT THE SCHOLARS’ HOME INSTITUTIONS TO ALIGN EFFORTS; AN ONLINE COHORT SUPPORT FORUM; AND OPPORTUNITIES TO PARTICIPATE IN NETWORKING, HONE SCIENTIFIC COMMUNICATION SKILLS, PREPARE FOR LEADERSHIP ROLES IN SCIENTIFIC SOCIETIES, AND INTERACT WITH FASEB COMMITTEES.

DESIGN: DRIVING CULTURE CHANGE IN A FEDERATION OF BIOLOGICAL SOCIETIES VIA COHORT-BASED EARLY-CAREER LEADERS -SCIENTIFIC SOCIETIES CAN PLAY A MAJOR ROLE IN CREATING A PROFESSIONAL CULTURE THAT IS WELCOMING TO INDIVIDUAL RESEARCHERS WHO ARE FROM GROUPS HISTORICALLY EXCLUDED FROM SCIENCE. THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB) IS AN ASSOCIATION OF 26 MEMBER SOCIETIES IN THE BIOLOGICAL SCIENCES AND WILL USE ITS RESOURCES AND CONNECTIONS TO DRIVE THIS CULTURE CHANGE TO BENEFIT DIVERSE EARLY-CAREER RESEARCHERS. A FEDERATED APPROACH ACROSS MULTIPLE SOCIETIES IS VALUABLE TO EXPANDING THE REACH OF THE PROJECT, ALLOWING FASEB TO AFFECT CULTURE CHANGE ON A LARGER SCALE IN BIOLOGY THROUGH ITS MEMBER SOCIETIES. IN THIS PROJECT, FASEB WILL ANALYZE AND DEFINE BARRIERS TO INCLUSIVITY IN THE ENTRENCHED CULTURE AND IDENTIFY MECHANISMS TO OVERCOME THESE BARRIERS. IN ADDITION, THE PROJECT WILL PROVIDE MENTORSHIP, SUPPORT, AND LEADERSHIP TRAINING TO COHORTS OF EARLY-CAREER RESEARCHERS FROM HISTORICALLY EXCLUDED POPULATIONS AND ASSIST THEM IN ENGAGING IN SOCIETY ROLES. THROUGH THIS MECHANISM OF INCREASED INVOLVEMENT, LEADERSHIP, AND RECOGNITION OF THEIR EFFORTS, PARTICIPANTS WILL DEVELOP A SENSE OF BELONGING AND GROW TO SERVE AS CHANGE AGENTS AS THEY DEVELOP AS LEADERS IN THEIR HOME SOCIETIES. WITH NEW COHORTS FORMING ANNUALLY, THIS CULTURE CHANGE IMPACT WILL CONTINUE TO GROW OVER THE YEARS. THIS PROJECT AIMS TO CHANGE THE CURRENT CULTURE OF BIOLOGICAL SOCIETIES THAT NEGATIVELY AFFECTS DIVERSE EARLY-CAREER RESEARCHERS. THE CULTURAL FOCUS IS ON ACTIVE PARTICIPATION IN SOCIETY ACTIVITIES; THE ABILITY TO ENTER SOCIETY LEADERSHIP POSITIONS; AND INVITATIONS INTO CULTURAL NORMS NEEDED FOR RETENTION IN A RESEARCH CAREER, SUCH AS NETWORKING, COLLABORATIVE GRANT APPLICATIONS, PUBLICATIONS, AND CONFERENCE ATTENDANCE. THE PROJECT OBJECTIVES ARE TO (1) DOCUMENT THE CURRENT BASELINE RELATED TO CURRENT POLICIES AND PRACTICES AND RECOMMENDATIONS TO PROMOTE INCLUSION FROM FASEB?S MEMBER SOCIETIES; (2) PILOT A COHORT-BASED PROJECT FOR EARLY-CAREER RESEARCHERS THAT PROVIDES MENTORSHIP, SUPPORT, AND LEADERSHIP TRAINING AND DEMONSTRATES INCREASED ENGAGEMENT IN SOCIETIES, SENSE OF BELONGING, AND ABILITY TO SERVE AS A CHANGE AGENT; AND (3) CREATE AN INFRASTRUCTURE FOR CHANGE THROUGH IDENTIFIED STRATEGIES, RESOURCE SHARING ACROSS MEMBER SOCIETIES, AND OUTREACH. STRATEGIES TO ADDRESS BARRIERS WILL SERVE AS THE FOUNDATION FOR FUTURE SUPPORT TO BE SHARED ACROSS SOCIETIES AND WILL PROVIDE A FRAMEWORK FOR THE PARTICIPANTS TO ACT AS CHANGE AGENTS. EVALUATION DATA FROM THE PILOT IMPLEMENTATION WILL PROVIDE PRELIMINARY EVIDENCE OF THE EFFECTIVENESS OF INITIATING CULTURE CHANGE THROUGH MENTORING, LEADERSHIP TRAINING, AND VIRTUAL COMMUNITY SUPPORT. PROJECT DATA WILL EXAMINE THE EFFECTIVENESS OF PROPAGATING RESOURCES AND CHANGE STRATEGIES THROUGH MULTIPLE SOCIETIES USING A FEDERATED APPROACH. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

FASEB SRC RETINAL NEUROBIOLOGY & VISUAL PROCESSING

PURPOSE: THE PURPOSE OF THIS AGREEMENT IS TO GATHER INFORMATION REGARDING THE IMPLEMENTATION OF THE CONTINGENCY PLAN RULE BY REGISTERED RESEARCH FACILITIES, INCLUDING SUCCESSES, AREAS OF CONCERN, AND OPPORTUNITIES FOR IMPROVEMENT AND ADDITIONAL OUTREACH TO ENHANCE COMPLIANCE. ACTIVITIES TO BE PERFORMED: IN COLLABORATION WITH APHIS ANIMAL CARE, THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB) WILL GENERATE AND DISTRIBUTE A SURVEY TO REGISTERED RESEARCH FACILITIES TO CHARACTERIZE THEIR EXPERIENCE GENERATING, TRAINING, IMPLEMENTING, AND REVIEWING THEIR CONTINGENCY PLANS. DELIVERABLES AND EXPECTED OUTCOMES: FASEB WILL ANALYZE THE DATA AND GENERATE A REPORT INCLUDING RECOMMENDATIONS FOR THE AGENCY. INTENDED BENEFICIARIES: APHIS ANIMAL CARE WILL BENEFIT FROM A BETTER UNDERSTANDING OF RESEARCH FACILITY CONTINGENCY PLAN IMPLEMENTATION, AND THE GENERAL PUBLIC WILL BENEFIT THROUGH ENHANCED TRANSPARENCY OF RESEARCH FACILITY COMPLIANCE WITH ANIMAL WELFARE REGULATIONS. SUBAWARDS: NO SUBAWARDS PLANNED.

BIOMEDICAL TRAINING PROGRAM DIRECTORS’ CONFERENCE - THIS PROPOSAL IS FOR R13 SUPPORT FOR THE BIOMEDICAL TRAINING PROGRAM DIRECTORS’ CONFERENCE. THIS BIENNIAL PROGRAM DIRECTORS’ MEETING WOULD PROVIDE ~500 PROGRAM DIRECTORS, ADMINISTRATORS, AND NIGMS PROGRAM STAFF WITH 2.5 DAYS OF FORMAL AND INFORMAL SESSIONS DESIGNED TO PROMOTE AND ADVANCE BEST PRACTICE IN DEVELOPING A DIVERSE BIOMEDICAL WORKFORCE AND TO CATALYZE RESEARCH TRAINING INTERCHANGE. THE OVERARCHING GOAL IS TO BUILD UPON AND EXTEND THE PAST SUCCESS OF THE FORMER CONFERENCE FOR NIGMS TWD-FUNDED INSTITUTIONAL TRAINING PROGRAM DIRECTORS AND ADMINISTRATORS. THAT CONFERENCE WAS LAST ORGANIZED BY FASEB AND NIGMS STAFF IN 2019, AND THERE IS POPULAR DEMAND FROM THE TWD PROGRAM DIRECTORS ORGANIZATION (PDO) TO REVIVE THIS OPPORTUNITY TO GATHER IN PERSON. THE PROPOSED MEETING IS PRIMARILY INTENDED FOR PROGRAM DIRECTORS AND ASSOCIATE DEANS (OR THE EQUIVALENT) AT INSTITUTIONS WITH NIGMS TWD INSTITUTIONAL TRAINING PROGRAMS INCLUDING: BRIDGES TO THE BACCALAUREATE, BRIDGES TO THE DOCTORATE, G-RISE, IMSD, IRACDA, MARC, MSTP, PREP, U-RISE, AND T32 PREAND POSTDOCTORAL PROGRAMS. HIGH-QUALITY INTERACTIVE PRESENTATIONS OF EVIDENCE-BASED RESEARCH TRAINING PRACTICES AND INTERVENTIONS WOULD BE COMBINED WITH INFORMAL ACTIVITIES TO ENCOURAGE NETWORKING AND EXCHANGE OF IDEAS. THE CONFERENCE WOULD PROVIDE INTERACTIVE OPPORTUNITIES FOR IN-DEPTH DISCUSSIONS AND TRAINING, WITH A MINIMUM OF PLATFORM LECTURES. THE 4 MAJOR THEMES OF THE CONFERENCE ARE INTERCONNECTED, AND DESIGNED TO DRIVE INSTITUTIONAL CHANGE TO IMPROVE TRAINING OF THE BIOMEDICAL AND BIOBEHAVIORAL WORKFORCE. THE THEMES ARE: 1) TRAINEE AND FACULTY WELLNESS; 2) ADVANCING RESEARCH MENTORING; 3) INCLUSIVE EXCELLENCE INCLUDING RECRUITING AND ADMISSIONS; AND 4) PROMOTING POSITIVE RESEARCH LABORATORY CULTURE. REPRESENTATION OF NEWER INVESTIGATORS, WOMEN, INDIVIDUALS FROM UNDERREPRESENTED GROUPS, AND ASPIRING PROGRAM DIRECTORS ARE KEY FACTORS FOR CONFERENCE ADMISSION. THE MEETING WOULD BE ORGANIZED BY THE TWD PDO STEERING COMMITTEE WITH THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB). THE PROPOSED MPI PLAN PROVIDES CONTINUITY FOR FUTURE CONFERENCES, AND ALLOWS FOR DISTRIBUTION OF EFFORTS; ONE MPI WOULD BE RESPONSIBLE FOR THE PROGRAMMING FOR EACH OF THE 4 MAJOR THEMES. NIGMS LEADERS WOULD BE INVITED TO ADDRESS THE CONFEREES, TO PARTICIPATE IN ALL SESSIONS, AND TO MEET PROGRAM DIRECTORS ONE-ON-ONE. THERE WOULD ALSO BE BREAKOUT SESSIONS FOR PROGRAM DIRECTORS FROM EACH OF THE VARIOUS TWD TRAINING PROGRAMS TO MEET AND EXCHANGE BEST PRACTICES WITH EACH OTHER. POSTER SESSIONS WOULD PROVIDE OPPORTUNITIES FOR INFORMAL DISCUSSIONS, NETWORKING AND EXCHANGE OF INFORMATION PERTAINING TO THE MAJOR THEMES. THE SPECIFIC AIMS ARE TO: 1) DEVELOP A MEETING PROGRAM THAT INFORMS AND ENGAGES THE THOUGHT LEADERS IN THE NIGMS TWD BIOMEDICAL RESEARCH TRAINING AND WORKFORCE DEVELOPMENT COMMUNITY; 2) PROMOTE COLLEGIAL INTERACTIONS, INCREASE COLLABORATIONS AND NETWORKING AMONG DIVERSE GROUPS OF PROGRAM DIRECTORS AND ADMINISTRATORS; 3) PROVIDE OPPORTUNITIES FOR EXCHANGE BETWEEN ATTENDEES AND NIGMS TWD PROGRAM STAFF.

RETINAL NEUROBIOLOGY AND VISUAL PROCESSING - PROJECT SUMMARY/ABSTRACT WE SEEK RENEWED PARTIAL SUPPORT FOR THE NEXT THREE MEETINGS (2024, 2026 AND 2028) OF THE PREMIER CONFERENCE ON RETINAL NEUROSCIENCE: “RETINAL NEUROBIOLOGY AND VISUAL PROCESSING,” ADMINISTERED BY THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB). THIS UNIQUE FORUM ATTRACTS TOP RETINAL AND VISION SCIENTISTS WITH DIVERSE BACKGROUNDS IN SYSTEMS AND CELLULAR NEUROBIOLOGY, COMPUTATIONAL AND DEVELOPMENTAL BIOLOGY AND VISION RESEARCH. INTERACTION IS EXTENSIVE THROUGHOUT THE FIVE-DAY MEETING AND OFFERS STIMULATING DEBATE, SOUND GUIDANCE, AND FERTILE GROUND FOR COLLABORATION. THE 2024 CONFERENCE WILL BE HELD JUNE 16 - 21 AT THE SOUTHBRIDGE HOTEL & CONFERENCE CENTER IN SOUTHBRIDGE, MASSACHUSETTS AND REPRESENTS THE 16TH MEETING OF THIS HIGHLY VALUED BIENNIAL CONFERENCE, WHICH WAS FIRST HELD IN 1992. THE PROVISIONAL PROGRAM PROVIDES A COMPREHENSIVE SURVEY OF GROUNDBREAKING NEW RESEARCH INTO TOPICS OF PROFOUND INTEREST TO THE EARLY-VISION COMMUNITY, INCLUDING: 1) RETINAL SYNAPSES; 2) CIRCUIT DEVELOPMENT; 3) PHOTORECEPTORS AND OUTER RETINAL PROCESSING; 4) RETINAL GANGLION CELLS: CODING AND COMPUTATION; 5) NON-IMAGE FORMING VISION; 6) RETINAL PATHWAYS AND BEHAVIOR; 7) DEGENERATION AND REGENERATION AND 8) VISUAL PROCESSING: BEYOND THE RETINA. IN ADDITION, TWO INTERACTIVE WORKSHOPS ARE PLANNED: NEW ADVANCES IN MOLECULAR TECHNIQUES FOR CELLULAR AND SYSTEMS NEUROSCIENCE; AND CAREER DEVELOPMENT FOR EARLY INVESTIGATORS. TWO SPECIAL SESSIONS WILL FEATURE EXCITING AND TIMELY WORK SELECTED FROM SUBMITTED POSTER ABSTRACTS FROM JUNIOR COLLEAGUES, ESPECIALLY GRADUATE STUDENTS. THESE HIGHLY POPULAR “DATA BLITZ” SESSIONS ALLOW 24 JUNIOR COLLEAGUES TO PRESENT A FIVE-MINUTE SYNOPSIS OF THEIR POSTER TO THE FULL CONFERENCE AUDIENCE. THIS ENSURES ACTIVE ENGAGEMENT OF JUNIOR PARTICIPANTS AND STIMULATES ATTENDANCE AT THE POSTER SESSIONS. PROGRAMMING FOR THE 2026 AND 2028 MEETINGS WILL BE DEVELOPED CLOSER TO THOSE DATES, TO ALLOW ORGANIZERS TO FEATURE THE LATEST WORK, BUT THE GOALS REMAIN CONSTANT: A DIVERSE AND ENGAGING SET OF FORMAL PRESENTATIONS; AND INTENSIVE AND PRODUCTIVE INFORMAL EXCHANGES SPANNING THE RETINAL PROCESSING FIELD. AS REFLECTED IN THE PROPOSED PROGRAM AND DOCUMENTED POSITIVE FEEDBACK FROM YOUNGER ATTENDEES, WE DESIGN THE MEETING TO ENGAGE AND SERVE OUR PRE- AND POSTDOCTORAL TRAINEES, AS WELL AS EARLY-STAGE INDEPENDENT INVESTIGATORS. WE PROVIDE TRAVEL AWARDS TO HELP JUNIOR MEMBERS ATTEND THE MEETING, PROVIDE OPPORTUNITIES TO SPEAK OR OTHERWISE PRESENT THEIR WORK AND PROVIDE POSTER PRIZES TO ACKNOWLEDGE THEIR ACCOMPLISHMENTS. GRADUATE STUDENTS OBTAIN EXPERIENCE IN PUBLIC PRESENTATION, EXPAND THEIR CONCEPTUAL AND TECHNICAL HORIZONS AND ENJOY EXTENDED ACCESS TO WORLD-CLASS FACULTY AS THEY PLAN THE NEXT STAGE OF THEIR CAREERS. WE RESERVE MANY PLENARY TALKS FOR ADVANCED POSTDOCTORAL FELLOWS AND JUNIOR FACULTY TO ENHANCE THEIR VISIBILITY AND CAREER DEVELOPMENT AND PLACE SPECIAL EMPHASIS ON RECRUITING SPEAKERS FROM UNDERREPRESENTED GROUPS IN SCIENCE.

FASEB'S THE BIOLOGY AND CHEMISTRY OF VISION CONFERENCE - PROJECT SUMMARY THIS APPLICATION SEEKS FUNDS FOR JUNIOR INVESTIGATORS AND TRAINEES TO ATTEND THE BIENNIAL FEDERATION OF AMERICAN SOCIETIES OF EXPERIMENTAL BIOLOGY (FASEB) SCIENCE RESEARCH CONFERENCES ON THE “THE BIOLOGY AND CHEMISTRY OF VISION”. SINCE ITS INCEPTION IN 1985, THIS HAS BEEN ONE OF THE MOST SUCCESSFUL AND INFLUENTIAL MEETINGS FOCUSED ON PHOTORECEPTOR BIOLOGY. THE MAJOR GOAL OF THE MEETING IS TO BRING TOGETHER ESTABLISHED AND YOUNG SCIENTISTS TO DISCUSS THE MOST RECENT ADVANCES IN THE BROAD AND DIVERSE FIELDS OF PHOTORECEPTOR BIOLOGY AND PATHOBIOLOGY. THIS FOCUSED MEETING IS HELD IN AN INTIMATE SETTING (SMALL CONFERENCE CENTER WITH SHARED MEALS) FOR A RELATIVELY SMALL NUMBER OF RESEARCHERS (~150) IN ORDER TO CATALYZE SCIENTIFIC INTERCHANGE. THE PROGRAM COMBINES HIGH- QUALITY, FORMAL PRESENTATIONS OF NOVEL EXPERIMENTAL RESULTS WITH INFORMAL INTERACTIONS IN A FRIENDLY, COLLEGIAL ATMOSPHERE. THE MEETING ALSO HAS TREMENDOUS EDUCATIONAL, CAREER-DEVELOPMENT AND NETWORKING VALUE FOR JUNIOR INVESTIGATORS. ACCORDINGLY, THE FUNDING REQUESTED IN THIS APPLICATION WILL BE USED FOR COVERING THE TRAVEL EXPENSES AND CONFERENCE FEES FOR THE YOUNG SCIENTISTS, INCLUDING PRE- AND POST-DOCTORAL TRAINEES AND JUNIOR INVESTIGATORS AT THE LEVEL OF ASSISTANT PROFESSOR. THE PROGRAM EMPHASIZES THE MOST RECENT, AND OFTEN MOST CONTROVERSIAL, RESEARCH IN THE FIELD, ADDRESS TIMELY QUESTIONS AND IDENTIFIES EMERGING TRENDS, ALL OF WHICH CATALYZES COLLABORATIONS FOR FUTURE WORK. IN 2021, THE PROGRAM WILL INCLUDE 9 PLATFORM SESSIONS, 4 POSTER SESSIONS, TWO DATABLITZ PRESENTATIONS, A KEYNOTE SPEAKER, AND A CAREER DEVELOPMENT WORKSHOP FOCUSED ON GRANT WRITING.

TRAINING, WORKFORCE DEVELOPMENT & DIVERSITY (TWD) PROGRAM DIRECTORS? MEETING

POST-TRANSCRIPTIONAL CONTROL OF GENE EXPRESSION: MECHANISMS OF MRNA DECAY

2011-15 FASEB SUMMER CONFERENCE ON AUTOIMMUNITY

FASEB SRC ON BIOLOGY AND CHEMISTRY OF VISION

FASEB SUMMER RESEARCH CONFERENCE ON RETINAL NEUROBIOLOGY AND VISUAL PROCESSING

FASEB SRC ON THE BIOLOGY AND CHEMISTRY OF VISION

FASEB SRC ON THE BIOLOGY AND CHEMISTRY OF VISION

FASEB SRC ON TRANSCRIPTION, CHROMATIN, & EPIGENETICS

THE LUNG EPITHELIUM IN HEALTH AND DISEASE - PROJECT SUMMARY THE 2026 FASEB SUMMER RESEARCH CONFERENCE, THE LUNG EPITHELIUM IN HEALTH AND DISEASE , IS THE 13TH BIANNUAL CONFERENCE IN THIS AREA, BRINGING TOGETHER DEVELOPMENTAL, CELL AND MOLECULAR BIOLOGISTS, GENETICISTS, PHYSIOLOGISTS, CLINICIANS AND TRANSLATIONAL RESEARCHERS WITH A PRIMARY INTEREST IN LUNG EPITHELIAL BIOLOGY. THE TOPICS SELECTED REPRESENT THE CUTTING-EDGE OF LUNG RESEARCH AND THE PROGRAM IS PLANNED TO DISSEMINATE NEW FINDINGS WITH TRANSLATIONAL POTENTIAL TO ACCELERATE PROGRESS TOWARD NOVEL THERAPIES FOR LUNG DISEASE. TOPICS INCLUDE (1) MOLECULAR MECHANISMS OF LUNG EPITHELIAL DEVELOPMENT, REPAIR/REGENERATION, AND PLASTICITY, (2) COMMON AND UNIQUE PATHWAYS OF INTRA-EPITHELIAL COMMUNICATIONS IN LUNG PHYSIOLOGY AND DISEASES, (3) INTERACTIONS BETWEEN LUNG EPITHELIUM AND DISTINCT IMMUNE CELLS, AND (4) CUTTING-EDGE TECHNOLOGIES INCLUDING SINGLE-CELL ANALYSIS APPROACHES AND EX-VIVO MODELS FOR INVESTIGATING LUNG EPITHELIAL BIOLOGY. IN ADDITION TO THE UNIQUE COLLECTION OF RESEARCH TOPICS, THIS MEETING PROVIDES A PLATFORM FOR NEW SPEAKERS, EARLY STAGE INVESTIGATORS, AND TRAINEES. 8 OF 24 INVITED SPEAKERS (33%) ARE ESI AND 20/24 HAVE NOT SPOKEN AT THIS CONFERENCE IN THE LAST FOUR YEARS. FOURTEEN SHORT-TALK SESSIONS ARE DESIGNATED FOR TRAINEES OR NEW INVESTIGATORS. IN ADDITION TO TALKS, THERE ARE 3 POSTER SESSIONS AND 3 “MEET-THE-EXPERTS” SESSIONS TO FACILITATE SCIENTIFIC AND SOCIAL INTERACTIONS BETWEEN ALL PARTICIPANTS. BY BRINGING THE BEST OF THE LUNG EPITHELIUM RESEARCH COMMUNITY TOGETHER, THE OVERALL GOAL OF THIS CONFERENCE IS TO PUSH THE FIELD FORWARD TOWARDS INNOVATIVE DIRECTIONS FOR BASIC RESEARCH AND NOVEL THERAPEUTICS FOR IMPORTANT LUNG DISEASES, INCLUDING ARDS, ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, PULMONARY FIBROSIS, AND BRONCHOPULMONARY DYSPLASIA.

GI EPITHELIUM: INTERFACE WITH THE OUTSIDE WORLD - THIS APPLICATION IS SEEKING TRAVEL SUPPORT FOR EARLY-CAREER INVESTIGATORS, STUDENTS, AND POST-DOCS TO TRAVEL ATTEND A FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB) SCIENTIFIC RESEARCH CONFERENCE FOCUSED ON INSPIRING AND ENERGIZING THE GASTROINTESTINAL (GI) RESEARCH COMMUNITY: GI EPITHELIUM 2025: SPECIALIZATION, PLASTICITY, AND PATHWAYS TO DISEASE. THE MEETING, SCHEDULED FOR THE WEEK OF SEPTEMBER 7TH, 2025, AT SOUTHBRIDGE HOTEL AND CONFERENCE CENTER IN SOUTHBRIDGE, MA, WILL HELP PREPARE THE NEXT GENERATION OF INDEPENDENT RESEARCHERS FOCUSED ON GI HEALTH AND DISEASE. THE ORGANIZERS OF THE MEETING ARE ALL FUNDED BY THE NATIONAL INSTITUTE FOR DIGESTIVE DISEASE AND KIDNEY, AND WE SHARE THE GOAL OF STRENGTHENING INNOVATIVE SCIENCE THAT WILL POSITIVELY IMPACT HEALTH RELATED TO THE GASTROINTESTINAL TRACT. THE FASEB GASTROINTESTINAL TRACK SCIENTIFIC CONFERENCES REPRESENT A SERIES OF HIGHLY SUCCESSFUL CONFERENCES HELD BIENNIALLY SINCE 1985 WITH THE ADDITION OF A GI EPITHELIAL MEETING ON ALTERNATING YEARS STARTING IN 2023. GIVEN THE BREADTH, DEPTH, AND IMPACT OF RESEARCH INTO GASTROINTESTINAL PHYSIOLOGY AND PATHOLOGY, AS WELL AS THE BENEFITS OF IN-PERSON INTERACTION, IT IS APPROPRIATE TO HOLD AN ANNUAL MEETING FOR EXCHANGE OF IDEAS, NEW KNOWLEDGE OF THE FIELD, NURTURING COLLABORATIONS, AND MENTORING THE NEXT GENERATION OF GI INVESTIGATORS. IN THE LAST 15 YEARS, ADVANCES IN MULTI-OMIC TECHNOLOGIES, ORGANOID MODELS, SINGLE-CELL APPROACHES, SPATIAL TRANSCRIPTOMICS, AND STEM CELL CULTURE METHODOLOGIES HAVE SPURRED MAJOR GROWTH IN IMPACTFUL SCIENCE STUDYING THE ROLE OF THE GASTROINTESTINAL EPITHELIUM IN HEALTH AND DISEASE. TO REFLECT THIS PROGRESS, WE HAVE IDENTIFIED LEADERS IN THE FIELD TO SERVE AS KEYNOTE AND ANCHOR SPEAKERS IN SESSIONS THROUGHOUT THE MEETING. IN ADDITION TO THESE WELL-ESTABLISHED SPEAKERS, OUR GOAL IS TO INTENTIONALLY INVITE AND INCLUDE EARLY-CAREER INVESTIGATORS, STUDENTS, POST-DOCS IN THE MEETING TO MIX WITH THE MORE ESTABLISHED CAREER LEADERS, BOOST THEIR EARLY CAREERS, AND CREATE A DYNAMIC MEETING AND EXCHANGE OF IDEAS. EARLY-STAGE TRAINEES WILL ALSO PARTICIPATE IN CAREER DEVELOPING AND NETWORKING SESSIONS. A WORKSHOP IN “BEST PRACTICES IN RESEARCH WITH ORGANOIDS” WILL ALSO HELP INCREASE RIGOR AND REPRODUCIBILITY ACROSS NIDDK FUNDED STUDIES BY FILLING THIS IMPORTANT NEED IN THE FIELD. TO ENSURE PARTICIPATION OF EARLY-STAGE INVESTIGATORS AND TRAINEES IN THIS IMPACTFUL MEETING, WE ARE REQUESTING FUNDING TO OFFSET TRAVEL COSTS. OUR GOAL WITH THIS IN-PERSON MEETING IS TO BUILD AND STRENGTHEN THE GI RESEARCH COMMUNITY AND FOSTER NEW COLLABORATIONS. WHILE ZOOM MAKES IT EASIER THAN EVER FOR COLLABORATIONS BETWEEN INSTITUTIONS TO FLOURISH, IN-PERSON MEETINGS REMAIN AN ESSENTIAL WAY TO SPARK AND INITIATE THOSE COLLABORATIONS AND CROSS-INSTITUTIONAL MENTORSHIP OPPORTUNITIES. AS A GROUP OF ORGANIZERS, WE REPRESENT BOTH MDS AND PHDS, AND WE RECOGNIZE THAT ENCOURAGING DISCUSSION OF KEY CLINICAL PROBLEMS IN DIGESTIVE HEALTH AND IDENTIFYING CREATIVE RESEARCH APPROACHES TAKES COLLABORATION AND IDEA-SHARING. WE ARE EXCITED ABOUT OUR UPCOMING MEETING AND HOPE TO EFFECTIVELY PARTNER WITH NIH TO SUPPORT THE NEXT GENERATION OF DIGESTIVE DISEASE RESEARCHERS.

MOBILE DNA: MECHANISMS AND HEALTH IMPACT - MOBILE DNA ELEMENTS SHAPE THEIR HOST GENOMES. SINCE THE DISCOVERY OF TRANSPOSONS, MOST INVESTIGATIONS HAVE FOCUSED ON THEIR CONTRIBUTION TO GERM LINE DISEASES, WHICH PROVED TO BE RELEVANT TO HUMAN HEALTH. THE MAJOR DEPARTURE OF THE 2025 FASEB CONFERENCE FROM THIS LINE OF THINKING IS ITS FOCUS ON THE TE CONTRIBUTION TO SOMATIC GENETIC VARIATION AND ITS IMPACT ON NORMAL AGING AND AGE-ASSOCIATED DISEASES, SPECIFICALLY THOSE INVOLVING TRANSFORMATION, DEGENERATION, AND INFLAMMATION. WE’RE ALSO EMPHASIZING THE FUNCTIONAL ROLES OF TE-ENCODED PROTEINS AND MACROMOLECULAR ASSEMBLIES (ASPECTS THAT HAVE BEEN MORE CHALLENGING TO STUDY BUT FOR RECENT ANALYTICAL BREAK THROUGHS). INTEGRATION OF THESE RESEARCH THEMES INTO THE FASEB “MOBILE DNA: MECHANISMS AND HEALTH IMPACT” MEETING SETS IT APART FROM PREVIOUS FASEB CONFERENCES AS WELL AS OTHER TE- AND AGING-RELATED MEETINGS. INDEED, TWO MEMBERS OF THE ORGANIZING COMMITTEE ARE NIA-FUNDED INVESTIGATORS. A UNIQUE FEATURE OF THE 2025 CONFERENCE IS A DELIBERATE PUSH FOR UNDERSTANDING THE CONNECTION BETWEEN TES, PHENOTYPE, AND AGING – WITH EMPHASIS ON HUMAN HEALTH (E.G., CANCER, IMMUNITY, NEURODEGENERATION). OUR PROPOSED PROGRAM COVERS ALL KNOWN POINTS OF CONNECTION BETWEEN TES, AGING, AND AGING-RELATED DISEASES, MAKING IT A USEFUL OVERVIEW FOR ALL SUCH CONNECTIONS. WE ARE DRAWING TOGETHER A MIX OF TE AND AGING INVESTIGATORS THAT WILL PROMOTE THOUGHTFUL DISCUSSIONS AND INTER-DISCIPLINARY COLLABORATIONS. GOALS. THE OBJECTIVE OF THE 2025 FASEB CONFERENCE IS TO BUILD ON THIS TREND BY BRINGING TOGETHER INVESTIGATORS WITH COMMON INTERESTS IN MOBILE DNA AND ITS IMPACT ON SOMATIC AND GERMLINE GENOMIC VARIATION, THE AGING PROCESS, AND AGE-ASSOCIATED PATHOLOGIES. THE MAIN GOAL OF THE CONFERENCE IS TO SYNERGIZE THE TE AND AGING FIELDS. THUS, THE MEETING WILL FOCUS ON HIGHLIGHTING TRANSPOSON IMPACT ON AGE-ASSOCIATED DISEASES AS WELL AS MODELS AND TECHNOLOGIES THAT ARE AVAILABLE FOR RIGOROUS TE ANALYSIS WITH THE INTENT TO IMPROVE OUR ABILITY TO SCREEN, DIAGNOSE, AND/OR TREAT THESE DISEASES. INNOVATIONS. THE CONFERENCE WILL FACILITATE SHARING OF UNPUBLISHED FINDINGS AND DISCUSSION OF EXPERIMENTAL CHALLENGES AND OUTSTANDING QUESTIONS IN THESE TWO RAPIDLY EVOLVING FIELDS AMONG STUDENTS, POSTDOCTORAL TRAINEES, JUNIOR AND SENIOR PRINCIPAL INVESTIGATORS. THIS IS PARTICULARLY VALUABLE BECAUSE TES DO NOT CONFORM TO MENDELIAN GENETIC PRINCIPLES ALONE AND EXHIBIT UNIQUE FUNCTIONAL CHARACTERISTICS DISTINCT FROM “NORMAL HOST GENE PRODUCTS,” THEREFORE REQUIRING UNIQUE APPROACHES FOR THEIR ANALYSIS. OUR SESSION CHAIRS WILL GIVE TALKS THAT REVIEW THE SCIENTIFIC FIELD, AS RELEVANT TO THEIR SESSION TOPIC, AND WILL CONTEXTUALIZE THE OTHER TALKS WITHIN THE SESSION TO FOLLOW, TO ORIENT NEWCOMERS TO THE TOPICS. OUR CAREER DEVELOPMENT AND MEET-THE-EXPERTS SESSIONS WILL ASSIST NEW COMMUNITY MEMBERS IN DEVELOPING ROBUST STRATEGIES FOR SCIENTIFIC SUCCESSFUL AND INTRODUCE SCIENTISTS ACROSS FIELDS AND GENERATIONS TO CRITICAL CHALLENGES AT THE INTERFACE OF TES AND AGING.

FASEB'S TRANSCRIPTION, CHROMATIN AND EPIGENETICS IN AGING CONFERENCE - SUMMARY THE GOAL OF THIS FASEB MEETING “TRANSCRIPTION, CHROMATIN AND EPIGENETICS IN AGING” IS TO COVER THE ROLE NEW EPIGENETIC MECHANISMS IN THE REGULATION OF AGING AND IN ‘REJUVENATION’ STRATEGIES FOR AGE-RELATED DISEASES. EPIGENETIC MECHANISMS ENCOMPASS POST-TRANSLATIONAL MODIFICATIONS OF CHROMATIN AND RNA AS WELL AS TRANSCRIPTIONAL REGULATION. THIS FASEB MEETING WILL BE UNIQUE IN INTEGRATING THE LATEST DISCOVERIES IN EPIGENETICS AND THEIR IMPORTANCE IN AGING AND ‘REJUVENATION’ STRATEGIES FOR AGE-RELATED DISEASES. THERE IS A VITAL NEED FOR SUCH A MEETING. EXCITING RECENT STUDIES HAVE REVEALED HOW ORGANISMAL AND CELLULAR AGING CAN BE REGULATED BY EPIGENETIC MECHANISMS. THE FIELD OF EPIGENETIC IS RAPIDLY EXPANDING, AND THE AGING FIELD NEEDS TO BENEFIT FROM THE LATEST AND GREATEST DISCOVERIES IN THIS AREA. CONVERSELY, CHALLENGES AND QUESTIONS ABOUT THE ROLE OF EPIGENETICS IN AGING AND AGE-RELATED DISEASES ABOUND, AND IT IS CRITICAL FOR RESEARCHERS IN THE CHROMATIN AND TRANSCRIPTION FIELDS TO BETTER GRASP THE IMPLICATIONS OF THEIR WORK FOR HEALTH AND DISEASE. THIS FASEB MEETING WILL DISCUSS THE MOST CUTTING-EDGE QUESTIONS IN FIELD OF CHROMATIN, TRANSCRIPTION, AND EPIGENETICS. A KEY TOPIC WILL BE THE UNDERLYING MOLECULAR BASIS OF EPIGENETIC MECHANISMS. THE QUESTION OF HOW THESE MECHANISMS GET DYSREGULATED DURING NORMAL AGING AND DISEASE WILL ALSO BE DISCUSSED. THE MEETING WILL ALSO COVER NEW FRONTIERS, INCLUDING THE EXCITING EMERGING FIELD OF THREE-DIMENSIONAL CHROMATIN STRUCTURE AND RNA EPIGENOMICS. THE MEETING WILL PARTICULARLY FOCUS ON TRANSFORMATIVE EPIGENOMIC TECHNOLOGIES AT THE SINGLE CELL AND SINGLE MOLECULE LEVELS AND HOW THEY CAN BE USED TO BUILD AND USE ‘EPIGENETIC CLOCKS’ IN CELLS FROM INDIVIDUALS AT DIFFERENT AGES AND TO IDENTIFY NOVEL ‘REJUVENATION’ STRATEGIES FOR DIFFERENT AGE-RELATED DISEASES. THIS MEETING SHOULD FOSTER EXCITING FUNDAMENTAL KNOWLEDGE AND INFORMATION, NEW METHODOLOGY AND TECHNICAL CAPABILITIES, AND INTERDISCIPLINARY COLLABORATIONS. THE MEETING WILL ALSO PROVIDE A UNIQUELY INTERACTIVE, DIVERSE, AND INCLUSIVE FORUM FOR TRAINEES AND NEW INVESTIGATORS IN VERY DIFFERENT AREAS, HIGHLIGHTING THEIR RESEARCH THROUGH SHORT TALKS, POSTER TEASERS AND SESSIONS AND PROMOTING SEVERAL NETWORKING AND MEET-THE-EXPERT EVENTS.

CALCIUM AND CELL FUNCTION - PROJECT SUMMARY THE OBJECTIVE OF THE 19TH FASEB SUMMER RESEARCH CONFERENCE ON CALCIUM AND CELL FUNCTION IS TO STIMULATE DISCOURSE, SEED NEW IDEAS, AND PROMOTE COLLABORATIONS TO ACCELERATE NEW DISCOVERIES ON CALCIUM SIGNALING AT THE BASIC AND TRANSLATIONAL LEVELS. CALCIUM IS A UNIVERSAL SIGNALING MOLECULE CONTROLLING A VAST ARRAY OF CELL FUNCTIONS AND THUS PLAYS AN IMPORTANT ROLE IN THE NERVOUS, CARDIOVASCULAR, AND IMMUNE SYSTEMS AS WELL AS MANY OTHER ORGANS. BASIC SCIENCE DISCOVERY INTO THE PHYSIOLOGY OF CALCIUM TRANSPORTERS AND BINDING PROTEINS HAS BEEN ACCOMPANIED BY NEW INSIGHTS INTO THE PATHOPHYSIOLOGICAL ROLE OF ABNORMAL CALCIUM SIGNALS IN NUMEROUS DISEASES, SUCH AS ALZHEIMER’S DISEASE, CARDIAC ARRHYTHMIAS, AUTOIMMUNITY, AND CANCER. A COMPREHENSIVE UNDERSTANDING OF CALCIUM SIGNALING IS ESSENTIAL FOR THERAPEUTIC DEVELOPMENT AND IS OF HIGH INTEREST TO SCIENTISTS IN ACADEMIC AND BIOTECHNOLOGY SECTORS. THIS FASEB SUMMER RESEARCH CONFERENCE WILL BE HELD FROM JULY 6-10, 2025, IN WINNIPEG, CANADA. IT WILL INCLUDE THREE KEYNOTE ADDRESSES FROM LEADERS IN CALCIUM SIGNALING: MASAMITSU IINO (NIHON UNIVERSITY, JAPAN), TOBIAS MEYER (WEILL CORNELL MEDICINE), AND THOMAS C SUDHOF (STANFORD UNIVERSITY). IT WILL BE THE MOST SIGNIFICANT INTERNATIONAL MEETING OF THE CALCIUM FIELD IN 2025 AND A FORUM WHERE LEADING SCIENTISTS FROM AROUND THE WORLD COME TOGETHER TO PRESENT AND DISCUSS THEIR LATEST AND MOST IMPORTANT RESEARCH. THE CONFERENCE FORMAT COMPRISES 8 SESSIONS WITH 32 INVITED TALKS, 16 SHORT TALKS SELECTED FROM SUBMITTED ABSTRACTS, TWO POSTER SESSIONS, AND THREE CAREER DEVELOPMENT SESSIONS. SCIENTIFIC TALKS WILL COVER A WIDE SPECTRUM OF CALCIUM SIGNALING STUDIES FROM BASIC TO CLINICAL RESEARCH WITH A SPECIAL EMPHASIS ON THE NERVOUS SYSTEM AND AGING BIOLOGY. THIS HIGHLY INCLUSIVE CONFERENCE PROGRAM IS CRAFTED TO FOSTER INTERACTIONS BETWEEN TRAINEES, EARLY CAREER SCIENTISTS, AND ESTABLISHED INVESTIGATORS. AN IMPORTANT GOAL OF THIS CONFERENCE IS TO EMPOWER THE NEXT GENERATION OF SCIENTISTS. TO ACHIEVE THIS GOAL, WE SEEK FUNDING TO SUPPORT THE PARTICIPATION OF GRADUATE STUDENTS, POSTDOCTORAL RESEARCHERS, AND EARLY CAREER INVESTIGATORS, WITH A SPECIAL EMPHASIS ON INCLUDING WOMEN, UNDERREPRESENTED MINORITIES, AND INDIVIDUALS WITH DISABILITIES. THE LOGISTICAL ARRANGEMENTS OF THE CONFERENCE WILL PROVIDE NUMEROUS OPPORTUNITIES FOR ORGANIZED AND SPONTANEOUS INTERACTIONS, PROVIDING JUNIOR SCIENTISTS OPPORTUNITIES TO PRESENT THEIR WORK, OBTAIN VALUABLE FEEDBACK FROM LEADERS IN THE FIELD, AND RECEIVE GUIDANCE FOR CAREER DEVELOPMENT. SINCE ITS INCEPTION IN 1984, THIS BIENNIAL CONFERENCE HAS BEEN VERY SUCCESSFUL IN BRINGING TOGETHER LEADING INVESTIGATORS FROM DIVERSE FIELDS TO SHARE THE LATEST AND MOST EXCITING DEVELOPMENTS IN CALCIUM AND CELL FUNCTION. IT CONTINUES TO SERVE AS A UNIQUE PLATFORM FOR RESEARCHERS TO EXCHANGE IDEAS AND PROMOTE FUTURE COLLABORATIONS IN THIS DYNAMIC FIELD.

PROTEIN FOLDING IN THE CELL - PROJECT SUMMARY THIS PROPOSAL SEEKS FUNDING FOR 21 US-BASED EARLY CAREER SCIENTISTS (ECSS) TO ATTEND THE FASEB PROTEIN FOLDING IN THE CELL MEETING IN LOUISVILLE, KENTUCKY FROM JUNE 1-4, 2026. THIS CONFERENCE FOCUSES ON THE LATEST DEVELOPMENTS REGARDING HOW THE NATIVE CONFORMATIONS OF CELLULAR AND SECRETED PROTEINS ARE ACHIEVED AND MAINTAINED. THE MEETING’S FOCUS IS ON THE BASIC SCIENCE DEFINING PROTEIN HOMEOSTASIS, WHOSE DECLINE IS ESPECIALLY PROMINENT DURING AGING AND ASSOCIATED WITH MANY DIFFERENT NEURODEGENERATIVE DISEASES, INCLUDING ALZHEIMER’S DISEASE AND RELATED DEMENTIAS. THUS, WE WILL DEDICATE CLOSE TO HALF OF THE TALKS TO THIS TOPIC AND PAY PARTICULAR FOCUS ON RECENT ADVANCES IN THERAPEUTIC STRATEGIES. SPECIAL EMPHASIS FOR THE TRANSMISSION OF INFORMATION WILL BE PLACED BOTH ON THE FORMAL PRESENTATIONS AS WELL AS ON INFORMAL INTERACTIONS THROUGH ROUND TABLE DISCUSSIONS AND, GROUP BRAINSTORMING SESSIONS TO CATALYZE THE GENERATION OF NEW HYPOTHESES AND THE INITIATION OF COLLABORATIONS. GIVEN THE STRONG CONNECTION BETWEEN PROTEIN FOLDING AND PROTEIN DEGRADATION AND THE FACT THAT FAILURE IN EITHER OF THESE PROCESSES CONTRIBUTES TO AGING AND DISEASE, WE ARE EXCITED TO REPORT THAT WE WILL, FOR THE FIRST TIME, JOIN FORCES WITH THE FASEB UBIQUITIN (UB) MEETING. WE HAVE PRECISELY COORDINATED OUR TWO PROGRAMS IN AN EFFORT TO PROVIDE MAXIMAL INTERACTIONS. WE WILL ORGANIZE A JOINT IGNITE CAREER FORUM (SEE BELOW), AND WILL HOLD THE KEYNOTE SESSION, THE POSTER SESSIONS, TWO MORNING SESSIONS (HALF OF THE SPEAKERS FROM UB, HALF FROM PROTEIN FOLDING (PF)), AND ALL COFFEE BREAKS, LUNCHES, DINNERS AND WORKSHOPS TOGETHER. BY DOING SO, WE WILL SIGNIFICANTLY EXPAND THE BREADTH OF OUR COVERED TOPICS AND EXPOSE ECSS TO A MUCH BROADER RESEARCH COMMUNITY WHILE, AT THE SAME TIME, REDUCING THE NUMBER OF MARQUEE SPEAKERS IN THE INDIVIDUAL MEETINGS AND SAVING COSTS ON REGISTRATION. WE WILL ORGANIZE THE SECOND “IGNITE CAREER FORUM”, WHICH WILL TAKE PLACE RIGHT BEFORE THE MAIN MEETING, AND WILL GIVE SIXTEEN GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS THE OPPORTUNITY TO PRESENT THEIR RESEARCH. THE TWO BEST TALKS WILL BE AWARDED SPEAKING SLOTS IN THE JOINT MORNING SESSIONS OF THE MAIN MEETING. IN ADDITION, WE HAVE SET ASIDE 11 TALKS FOR INVITED ECSS AND ECSS SELECTED FROM THE SUBMITTED ABSTRACTS, WITH A FOCUS ON BRINGING POSTDOCS AND ASSISTANT PROFESSORS INTO THE MAIN PROGRAM. FUNDING IS SOUGHT TO PROVIDE REGISTRATION AND TRAVEL AWARDS FOR THE 8 PRE-MEETING SPEAKERS (PF ONLY), THE TWO STUDENTS REPRESENTING PF ON THE ORGANIZATION COMMITTEE AS WELL AS THE 11 ECS, WHO WILL BE SELECTED FOR TALKS IN THE PF-PROGRAM. WE WILL ORGANIZE 2-MIN LIGHTNING TALKS FOR POSTER PRESENTERS. ROUND TABLE DISCUSSIONS OVER LUNCH WILL ENABLE ECSS TO DISCUSS TOPICS LIKE CAREERS, EFFECTIVE GRANT WRITING, HOW TO PICK THE BEST RESEARCH PROJECTS ETC. WITH EXPERTS IN THE FIELD.

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** A BETTER UNDERSTANDING OF NUTRIENT SENSING AND SIGNALINGWILL LED TO NEWINTERVENTIONSTO PREVENT OR DELAY THE ONSET OF METABOLIC DISORDERS AND CHRONIC DISEASES. THIS CONFERENCE PROPOSALDIRECTLY SUPPORTS THE AFRI FOOD SAFETY, NUTRITION, AND HEALTH PROGRAM UNDER THE DIET, NUTRITION AND THE PREVENTION OF CHRONIC DISEASES AREA AND ADDRESSES THE PRIORITY DEVELOP, IMPLEMENT AND EVALUATE INNOVATIVE RESEARCH STRATEGIES TO IMPROVE EATING PATTERNS THAT PREVENT AND CONTROL DIET-RELATED CHRONIC DISEASES AND THE PRIORITY APPROACH PRECISION NUTRITION (A1344).AS A RESULT OF THIS CONFERENCE, NEW APPROACHES TO STUDY DIET AND MEASURE METABOLISM WILL BE DISCUSSED IN AN INTERDISCIPLINARY SETTING, LEADING TO NEW AND DIFFERENT RESEARCH PARTNERSHIPS.NUTRIENT SENSINGAND SIGNALING AREKEY MECHANISMS IN THE DEVELOPMENT OF INSULIN RESISTANCE, METABOLIC SYNDROME, OBESITY, DYSLIPIDEMIA, METABOLIC ASSOCIATED LIVER STEATOSIS, CARDIOVASCULAR DISEASE, CANCER, DIABETES, NEUROLOGICAL DISEASE, SARCOPENIA AND CACHEXIA.THE PROPOSED CONFERENCE WILL BRING TOGETHER SCIENTISTS FROM MULTIPLE DISCIPLINES WITH A COMMON INTEREST IN NUTRIENT SENSING AND THE REGULATION OF METABOLISM AND CELL FUNCTION BY NUTRIENTS. IN THIS WAY, INVESTIGATORS USING MORE INTER-ORGAN AND HOLISTIC APPROACHES CAN SHARE EXPERTISE WITH THOSE WHOSE RESEARCH FOCUSES MORE ON A CELLULAR OR MOLECULAR LEVEL, AND VICE VERSA.ALL OF THE PLANNED CONFERENCE SESSIONS COVER CONCEPTS THAT ARE HIGHLY RELEVANT TO PRECISION/PERSONALIZED NUTRITION AND DIET-RELATED CHRONIC DISEASE. THE LINEUP OF SCIENTIFIC SESSION CHAIRS AND INVITED SPEAKERS INCLUDESRACIAL/ETHNIC MINORITIES, LGBTQ+, GEOGRAPHIC DIVERSITY, AND OTHERGROUPSUNDERREPRESENTED IN SCIENCE. FORMAL AND INFORMAL EVENTS ARE PLANNED TO FACILITATE NEW COLLABORATIONS AND CREATE A CHANGE IN KNOWLEDGE AMONG THE ATTENDEES.

PHOSPHOLIPIDS IN AGING AND DISEASE - PROJECT SUMMARY THIS PROPOSAL REQUESTS PARTIAL SUPPORT FOR THE FASEB RESEARCH CONFERENCE “PHOSPHOLIPID SIGNALING IN AGING AND DISEASE” TO BE HELD JULY 21-25, 2024, AT THE INTERCONTINENTAL HOTEL SAINT PAUL RIVERFRONT HOTEL IN ST. PAUL, MINNESOTA, USA. THIS CONFERENCE, WHICH BEGAN IN 1988 AND HAS BEEN ATTENDED BIENNIALLY BY RESEARCHERS FROM ACROSS THE WORLD, IS CRITICAL TO THE MISSIONS OF THE NIA BECAUSE LIPIDS ARE CRITICAL MEDIATORS OF SIGNALING, AGING, MITOCHONDRIAL BIOLOGY, METABOLISM, CANCER AND NEURODEGENERATION. ALTHOUGH THERE ARE SEVERAL CONFERENCES THAT FOCUS ON LIPID SIGNALING AND METABOLISM, THE PROPOSED 2024 FASEB CONFERENCE WILL HAVE A FOCUS ON LIPIDS AND AGING, LONGEVITY, METABOLISM, AND NEURODEGENERATION. THIS CONFERENCE WILL (1) BRING TOGETHER LEADING INVESTIGATORS IN LIPID METABOLISM AND SIGNALING IN AGING, HEALTH AND LONGEVITY, (2) HELP TRAIN THE NEXT GENERATION OF US INVESTIGATORS TO BRING NEW ADVANCES TO LIPID AND AGING DISCOVERY SCIENCES, AND (3) PROMOTE THE IMPROVEMENT OF HUMAN HEALTH BY INVESTIGATING LIPID METABOLISM AND SIGNALING IN AGING AND LONGEVITY. THE MAJOR GOALS OF THE 2024 FASEB CONFERENCE ON “PHOSPHOLIPID SIGNALING IN AGING AND DISEASE” ARE TO: (1) SHARE THE MOST CURRENT INFORMATION ON LIPID METABOLISM AND SIGNALING IN AGING, (2) FACILITATE NEW INTERACTIONS AMONG SCIENTISTS WHO DO NOT NORMALLY INTERACT IN RESEARCH, (3) PROMOTE INTERDISCIPLINARY INTERACTIONS THAT WILL LEAD TO NEW COLLABORATIONS, AND (4) ENABLE UNDERSTANDING AND TRANSLATIONAL RESEARCH LEADING TO SAFE HUMAN INTERVENTIONS TO IMPROVE HEALTHY AGING AND METABOLISM. WE EXPECT THAT THE NEW INSIGHTS THAT ARE FORMED DURING THE COURSE OF THIS MEETING WILL ADVANCE THE ENTIRE LIPID FIELD AND ESPECIALLY ADVANCE RESEARCH WITH A FOCUS ON LIPIDS IN AGING AND NEURODEGENERATION AS WELL AS LONGEVITY, METABOLISM, AND MITOCHONDRIAL BIOLOGY. THE OBJECTIVE OF THIS PROPOSAL IS TO OBTAIN FUNDS TO SUPPORT TRAVEL AND CONFERENCE FEES FOR SCIENTISTS, WITH A SPECIAL EMPHASIS ON JUNIOR FACULTY, TRAINEES, AND THOSE THAT ARE UNDERREPRESENTED IN SCIENCE. THE ORGANIZING COMMITTEE CONSISTS OF FOUR MEMBERS (DRS. BURKE, EMERLING, HIRSCH, AND TOOZE), WHO WERE NOMINATED BY THE 2022 FASEB PHOSPHOLIPIDS: DYNAMIC LIPID SIGNALING IN HEALTH AND DISEASE CONFERENCE ORGANIZERS. EACH ORGANIZER IS AN EXPERT IN ONE OR MORE OF THE TOPICS THAT WILL BE COVERED DURING THE COURSE OF THE MEETING. TOGETHER, THE INTERDISCIPLINARY COMMITTEE HAS A BROAD RANGE OF EXPERTISE IN LIPID RESEARCH RELATED TO LIPIDS IN AGING AND DISEASE. THE ORGANIZING COMMITTEE HAS MADE CALCULATED EFFORTS TO REPRESENT MAJOR AREAS OF LIPID METABOLISM AND SIGNALING IN AGING, FROM METABOLIC REGULATION TO SPECIFIC AREAS OF BIOLOGY AND DISEASE. FURTHER, SEVERAL WORKSHOPS ON LIPIDS AS WELL AS MENTORING SESSIONS WILL BE HELD, WHICH WE BELIEVE WILL PROVIDE 1) TRAINING ON LIPIDS AND LIPID CHANGES WITH AGING, AS WELL AS 2) NEW OPPORTUNITIES FOR ATTENDEES TO THINK ABOUT THEIR RESEARCH AND HOW IT CAN CROSSOVER INTO THE AGING FIELD.

2010 FASEB SUMMER CONFERENCE ON THE BIOLOGY OF INTEGRATED NUCLEAR AND EXTRANUCLEAR STEROID SIGNALING. CONFERENCE PROGRAM AUGUST 8 - 12 2010 ASPEN

FASEB'S THE REPRODUCTIVE AGING CONFERENCE - PROJECT SUMMARY WE ARE REQUESTING FUNDS TO SUPPORT THE INAUGURAL 2021 FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB) REPRODUCTIVE AGING CONFERENCE, TO BE HELD AT THE OMNI RANCHO LAS PALMAS RESORT (PALM SPRINGS, CALIFORNIA, USA) ON MAY 23 - 27, 2021. AGING IN THE GONAD DRAMATICALLY AFFECTS AGING IN SOMATIC TISSUES, YET WE KNOW LITTLE ABOUT THE MECHANISMS REGULATING HEALTHY AGING IN REPRODUCTIVE ORGANS, NOR HOW THIS CROSSTALK IS ACHIEVED. THIS INAUGURAL CONFERENCE WILL FOCUS ON UNDERSTANDING MECHANISMS THAT REGULATE AGING IN REPRODUCTIVE TISSUES AND THEIR RELATIONSHIP TO OVERALL ORGANISMAL HEALTHSPAN AND LONGEVITY. FUNDS ARE REQUESTED TO HELP COVER EXPENSES OF 1) INVITED SPEAKERS AND 2) MERITORIOUS JUNIOR SCIENTISTS (STUDENTS, POSTDOCTORAL FELLOWS AND JUNIOR FACULTY) AND MINORITY TRAINEES WHO WILL BENEFIT FROM FORMAL AND INFORMAL INTERACTIONS WITH SENIOR SCIENTISTS, TO PRESENT THEIR RESEARCH FINDINGS, RECEIVE FEEDBACK FROM EXPERTS IN THE FIELD, AND EXCHANGE IDEAS FOR SHAPING THE FIELD. TO OUR KNOWLEDGE, THIS WILL BE THE FIRST INTERNATIONAL MEETING DEDICATED ENTIRELY TO THE TOPIC OF REPRODUCTIVE AGING. THE GOAL OF THE FASEB REPRODUCTIVE AGING CONFERENCE IS TO SHOWCASE RESEARCH AND STIMULATE COLLABORATIONS THAT BRIDGE THE DISCIPLINES OF REPRODUCTIVE BIOLOGY AND AGING RESEARCH TO HELP DEFINE NEW PARADIGMS TO ACCELERATE PROGRESS. OUR PRIMARY OBJECTIVE IS TO BECOME THE PREMIER FORUM FOR COALESCING THE FIELD AND FOSTERING THE DISCUSSION OF CONCEPTS AND PRESENTATION OF RESEARCH AT THE FOREFRONT OF DISCOVERY RELATED TO AGING IN THE REPRODUCTIVE SYSTEM AND ITS CONNECTION TO AGING IN THE REST OF THE BODY. REPRODUCTIVE AGING RESEARCH ENCOMPASSES MULTIPLE FRONTS OF INTEREST: IDENTIFICATION OF THE MOLECULAR AND CELLULAR MECHANISMS THAT REGULATE AGING IN REPRODUCTIVE ORGANS THAT FACILITATE OVERALL HEALTHSPAN AND LONGEVITY; MECHANISMS OF GERM CELL AND NICHE AGING AND HOW THESE MIGHT REGULATE SYSTEMIC AGING; AND DEVELOPING NEW MODELS TO STUDY THESE INTERACTIONS. THE INTERSECTION OF THESE HISTORICALLY SEPARATE AREAS, THE BASIC BIOLOGY OF AGING AND AGING IN THE REPRODUCTIVE TRACT, HAVE BEGUN TO MERGE AROUND COMMON MOLECULAR PRINCIPLES. INVITED SPEAKERS INCLUDE ESTABLISHED AS WELL AS OUTSTANDING EARLY CAREER SCIENTISTS SELECTED FOR THE QUALITY OF THEIR SCIENCE AND ABILITY TO STIMULATE DEBATE. THIS CONFERENCE WILL PROVIDE A FORUM FOR BOTH FORMAL AND INFORMAL INTERACTIONS BETWEEN TRAINEES AND FACULTY AT ALL STAGES TO PROMOTE THE EXCHANGE OF IDEAS AND COLLABORATIVE SYNERGIES AROUND REPRODUCTIVE AGING. POSTER AND ORAL PRESENTATIONS WILL EXAMINE REPRODUCTIVE AGING AT THE MOLECULAR, CELLULAR AND ORGANISMAL LEVEL, INCLUDING ITS MOLECULAR DRIVERS, AND THE EFFECTS OF GENETIC AND ENVIRONMENTAL FACTORS ON RELEVANT CELLULAR/SYSTEM PROPERTIES AND INTERACTIONS ACROSS DIVERSE MODEL SYSTEMS RANGING FROM WORMS TO HUMANS. THIS UNIQUE CONFERENCE WILL BRING TOGETHER SCIENTISTS TACKLING THIS PROBLEM FROM FUNDAMENTAL TO CLINICAL ANGLES TO BRAINSTORM CREATIVE WAYS TO BUILD AND STRENGTHEN THE FIELD.

FASEB SRC ON THE BIOLOGY OF CILIA AND FLAGELLA

FASEB CONFERENCE FOR SKELETAL MUSCLE SATELLITE AND STEM CELLS

B VITAMINS AND ONE-CARBON METABOLISM IN HEALTH AND DISEASE - PROJECT SUMMARY/ABSTRACT THIS R13 APPLICATION AIMS TO OBTAIN PARTIAL FUNDING FOR THE “B-VITAMINS AND ONE-CARBON METABOLISM IN HEALTH AND DISEASE” CONFERENCE SET TO CONVENE AUGUST 9-13, 2026, IN WASHINGTON, DC. THE MEETING IS PART OF THE FASEB SRC SERIES AND HAS ASSEMBLED BIENNIALLY SINCE ITS INCEPTION IN 1986 AND YEAR 2026 WILL MARK THE 40-TH ANNIVERSARY OF THE CONFERENCE. THE MEETING AIMS TO ASSEMBLE BASIC SCIENTISTS, CLINICIANS, EPIDEMIOLOGISTS, AND PUBLIC HEALTH EXPERTS TO PRESENT AND DISCUSS THE LATEST RESEARCH IN B-VITAMINS AND ONE-CARBON METABOLISM (OCM) AND GENERATE INTEGRATED KNOWLEDGE. IT BRINGS TOGETHER PROMINENT EXPERTS IN THE FIELD FROM ALL-OVER THE WORLD AND THE PROMISING YOUNG SCIENTISTS, STUDENTS AND POSTDOCS. THE SPECIFIC AIMS OF THE CONFERENCE ARE: 1) CONVENE THE WORLD EXPERTS, JUNIOR INVESTIGATORS, AND TRAINEES WORKING IN AREAS OF B-VITAMINS AND OCM, TO PRESENT, DISCUSS AND ANALYZE THE MOST RECENT, CUTTING-EDGE RESEARCH, WITH SPECIAL EMPHASIS ON UNPUBLISHED STUDIES; 2) ENGAGE THE STUDENTS, TRAINEES AND INVESTIGATORS WHO ARE NEW TO THE MEETING, TO PRESENT AND DISCUSS THEIR WORK, INTERACT AND RECEIVE FEEDBACK FROM EXPERTS, ESTABLISH COLLABORATIONS AND PROFESSIONAL CONNECTIONS; 3) PROMOTE PARTICIPATION IN THE CONFERENCE BY PROVIDING TRAVEL SUPPORT TO STUDENTS AND TRAINEES FOR OUTSTANDING ORAL AND POSTER PRESENTATIONS AND TRAVEL FUNDING ASSISTANCE FOR INVITED SPEAKERS. THE SCIENTIFIC AIMS OF THE 2026 MEETING INCLUDE: 1) INTEGRATE NEW EPIDEMIOLOGICAL DATA ON B-VITAMINS DEFICIENCIES IN THE MODERN WORLD: LINKS TO MALABSORPTION, MALNUTRITION, INFECTIOUS/CHRONIC DISEASES, INCLUDING OBESITY AND DIABETES. 2) EVALUATE DATA ON THE TRANSGENERATIONAL LINK BETWEEN THE MATERNAL/PATERNAL B-VITAMINS/OCM STATUS AND PERI/POST-NATAL OFFSPRING HEALTH: LINKS TO OBESITY, DIABETES, NEUROLOGICAL/PSYCHIATRIC/DEVELOPMENTAL DISORDERS. 3) UPDATE ADVANCES IN SCIENCE AND CLINICAL PRACTICE FOR DIAGNOSIS, PATHOPHYSIOLOGY, AND TREATMENT OF THE INHERITED METABOLIC DISORDERS IN B-VITAMINS & OCM PATHWAYS. 4) EVALUATE EFFICACY OF PERI-CONCEPTIONAL B-VITAMINS INTERVENTIONS IN IMPROVING BIOMARKERS AND OVERALL INFANT HEALTH. 5) ASSESS THE LATEST DATA ON GENOMIC AND EPIGENOMIC EFFECTS OF THE B-VITAMINS AND OCM STATUS IN HEALTH AND DISEASE. 6) INTEGRATE NEW DEVELOPMENTS ON THE ROLE OF B-VITAMINS AND OCM IN CANCER PREVENTION, DIAGNOSIS, PATHOPHYSIOLOGY AND TREATMENT. 7) DISCUSS LATEST DEVELOPMENTS ON THE “TWO SIDES OF THE COIN” ARGUMENT WITH REGARD TO B-VITAMINS SUPPLEMENTATION/FORTIFICATION. SPECIFIC AIMS WILL BE ACCOMPLISHED OVER 8 SESSIONS INCLUDING INVITED SPEAKERS’ PRESENTATIONS AND SHORT TALKS FROM YOUNG SCIENTISTS’ ABSTRACTS, TWO POSTER SESSIONS (2H EACH), & 3 PROFESSIONAL DEVELOPMENT SESSIONS: “CAREER OPPORTUNITIES IN ACADEMIA AND BEYOND”, “WRITING SUCCESSFUL GRANT APPLICATIONS” AND “MEET THE EDITOR”. A PLENARY SESSION “40 YEARS OF B-VITAMINS & ONE- CARBON METABOLISM CONFERENCE: ACHIEVEMENTS, DIRECTIONS AND GOALS FOR THE FUTURE” WILL DEFINE FUTURE DIRECTIONS FOR THE MEETING. INFORMAL INTERACTIONS AMONG ATTENDEES DURING MEALS, BREAKS, POSTER SESSIONS AND OUTDOOR RECREATIONAL ACTIVITIES ARE FREQUENT, AND PERSONAL INTERACTIONS ENSUE NEW IDEAS, RESEARCH DIRECTIONS, COLLABORATIONS, PROMOTE PROFESSIONAL DEVELOPMENT OF YOUNG INVESTIGATORS, AND ENERGIZE THE FUTURE OF THE FIELD.

FASEB SRC ON MOLECULAR MECHANISM AND PHYSIOLOGICAL CONSEQUENCES OF PROTEIN AGGREG

FASEB'S "THE NAD+ METABOLISM AND SIGNALING CONFERENCE" - SUMMARY THIS PROPOSAL REQUESTS PARTIAL SUPPORT FOR THE FASEB RESEARCH CONFERENCE ON “NAD+ METABOLISM AND SIGNALING” TO BE HELD JUNE 13-18, 2021 AT THE WESTIN SNOWMASS HOTEL, SNOWMASS, CO. THIS CONFERENCE, WHICH BEGAN IN 2009 AND HAS BEEN ATTENDED BIENNIALLY BY RESEARCHERS FROM ACROSS THE WORLD, IS CRITICAL TO THE MISSION OF THE NIA BECAUSE NAD+-DEPENDENT PROCESSES MEDIATE KEY ASPECTS OF HEALTHY AGING AND METABOLIC DISORDERS. ALTHOUGH THERE ARE SPECIALIZED CONFERENCES THAT FOCUS ON SIRTUINS, POLY(ADP-RIBOSE) POLYMERASES (PARPS), CALCIUM SIGNALING, AND DRUGS AND NUTRITIONAL INTERVENTIONS THAT INTERFACE WITH THE FUNDAMENTAL AND TRANSLATIONAL SCIENCE OF NAD+ (E.G., AGING, METABOLISM, CANCER), THIS CONFERENCE IS THE ONLY ONE THAT CUTS ACROSS ALL OF THESE AREAS. THE STRENGTH AND INNOVATION OF THIS MEETING IS THAT IT PROVIDES A UNIQUE VENUE FOR CROSS-DISCIPLINARY INTERACTIONS AMONG NAD+ BIOLOGISTS FROM DIVERSE AREAS, WHO USE A WIDE VARIETY OF APPROACHES AND MODEL SYSTEMS. THIS CONFERENCE WILL (1) BRING TOGETHER LEADING SCIENTISTS WORKING ON NAD+ METABOLISM AND SIGNALING, (2) CREATE NETWORKING AND CAREER OPPORTUNITIES FOR EARLY-STAGE INVESTIGATORS, (3) TRAIN THE NEXT GENERATION OF SCIENTISTS, AND (4) PROMOTE THE IMPROVEMENT OF HUMAN HEALTH AS IT PERTAINS TO NAD+ METABOLISM AND SIGNALING. THE MAJOR GOALS OF THIS CONFERENCE ARE TO: (1) SHARE THE MOST CURRENT INFORMATION ON NAD+ METABOLISM AND SIGNALING, (2) FOSTER NEW INTERACTIONS AMONG SCIENTISTS WHO DO NOT NORMALLY INTERACT TO PROMOTE INTERDISCIPLINARY INTERACTIONS AND COLLABORATIONS, (3) PROVIDE CAREER AND TRAINING OPPORTUNITIES FOR EARLY-STAGE INVESTIGATORS AND TRAINEES THROUGH INTERACTIONS WITH LEADERS IN THE FIELD, AND (4) FACILITATE TRANSLATIONAL RESEARCH LEADING TO IMPROVEMENTS IN HEALTHY AGING AND OTHER ASPECTS OF HUMAN HEALTH. WE EXPECT THAT NEW INSIGHTS FROM THIS MEETING WILL ADVANCE THE ENTIRE FIELD AND LEAD TO A GREATER EVIDENCE-BASED UNDERSTANDING OF NAD+ METABOLISM IN HEALTHY PEOPLE, AS WELL AS IN INDIVIDUALS AFFECTED BY DISEASES OF AGING. THE OBJECTIVE OF THIS PROPOSAL IS TO OBTAIN FUNDS TO SUPPORT CONFERENCE FEES FOR OUTSTANDING JUNIOR INVESTIGATORS, AS WELL AS THOSE WHO ARE UNDERREPRESENTED IN SCIENCE. TO MEET THESE GOALS AND OBJECTIVE, WE PROPOSE THREE SPECIFIC AIMS: (1) FINALIZE THE SCIENTIFIC PROGRAM BY SELECTING INDIVIDUALS FROM THE SUBMITTED ABSTRACTS TO PRESENT SHORT TALKS THAT WILL COMPLEMENT OTHER TALKS PRESENTED AT THE MEETING; (2) IDENTIFY EARLY-STAGE SCIENTISTS AND TRAINEES WHO WILL RECEIVE FINANCIAL SUPPORT, AND (3) PROVIDE ADMINISTRATIVE SUPPORT TO DISTRIBUTE THE FUNDS FROM THIS R13 MECHANISM. THE ORGANIZING COMMITTEE COMPRISES FOUR MEMBERS (DRS. KRAUS, MOSTOSLAVSKY, GORBUNOVA, AND GUSE), WHO WERE NOMINATED BY THE 2019 FASEB NAD+ METABOLISM AND SIGNALING CONFERENCE ORGANIZERS AND VOTED ON BY THE PARTICIPANTS AT THAT MEETING. EACH MEMBER IS AN EXPERT IN ONE OR MORE OF THE TOPICS THAT WILL BE COVERED DURING THE COURSE OF THE MEETING. THE ORGANIZERS HAVE RELIED ON THEIR DIVERSE BACKGROUNDS AND BROAD RANGE OF EXPERTISE TO ORGANIZE A COMPREHENSIVE MEETING COVERING ALL MAJOR AREAS OF NAD+ METABOLISM AND SIGNALING RESEARCH. NEW AND EXCITING IDEAS WILL UNDOUBTEDLY EMERGE FROM SUCH DIVERSE, BUT ULTIMATELY UNIFYING TOPICS.

TGF-BETA SUPERFAMILY: SIGNALING AND DEVELOPMENT

NAD METABOLISM AND SIGNALING - PROJECT SUMMARY THE 2024 FASEB NAD METABOLISM AND SIGNALING MEETING SERVES TO UNITE RESEARCHERS AND CLINICIANS WHO SHARE THE DESIRE TO ELUCIDATE NAD-DEPENDENT MECHANISMS AND TO EVALUATE THE POTENTIAL FOR NAD-BASED APPROACHES FOR IMPROVING HUMAN HEALTH. THIS MEETING OVERCOMES BARRIERS THAT INEVITABLY FORM AROUND SUB- DISCIPLINES AND PROMOTES NEW COLLABORATIONS. THE MEETING ATTRACTS ATTENDEES WHO WORK IN DIFFERENT FIELDS AND RETAINS A CLEAR FOCUS AND INTERACTIVE CLIMATE. THIS PROMOTES GENUINE DISCOURSE, SINCERE COLLABORATION, SHARING OF UNPUBLISHED DATA, AND EXCHANGE OF BURGEONING IDEAS. IN TURN, THIS MEETING HAS ACCELERATED THE PACE OF DISCOVERY, EXPANSION OF NAD RESEARCH INTO NEW AREAS, AND RESULTED IN FORWARD PROGRESS OF THE FIELD. IN 2024 WE SEEK TO ACCOMMODATE THIS GROWING AND DYNAMIC FIELD, TO PUSH FOR TECHNICAL BREAKTHROUGHS, TO OBTAIN CLARITY IN MEASUREMENT STANDARDS AND EVALUATION CRITERIA FOR HUMAN TRIALS, AND TO WELCOME INVESTIGATORS FROM NEW AREAS OF RESEARCH INTO OUR COMMUNITY. WE ARE HOSTING NEW TOPIC-SPECIFIC SESSIONS FOR CANCER AND NEUROBIOLOGY, AND WILL PILOT A PRE-MEETING EVENT FOR TRAINEES CALLED PRECURSORS. WE ARE ALSO HOSTING A DEDICATED SPEAKER SESSION FOR CLINICAL TRIALS, AS WELL AS A PROFESSIONALLY MODERATED PANEL WITH THE OBJECTIVE TO DEVELOP DISCOURSE AND CONSENSUS AROUND HOW TO APPROACH STUDIES OF NAD IN HUMAN HEALTH. THE BREADTH OF THIS MEETING ENCOMPASSES A VAST DIVERSITY OF BIOLOGICAL TOPICS AND DISEASES, AS WELL AS INCLUDES THE ENTIRE NAD METABOLOME SUCH AS NAD+, NADH, NADP+, NADPH, NAADP, ADP-RIBOSE, CYCLIC ADPR, METHYLATED-NAM, AND PYRIDONE NUCLEOTIDES. THE MEETING FURTHER HOSTS RESEARCHERS WHO USE APPROACHES THAT SCALE FROM ATOMIC STRUCTURAL ANALYSES TO HUMAN PHYSIOLOGY. REPRESENTED FIELDS INCLUDE CHEMISTRY, BIOCHEMISTRY, MOLECULAR AND CELL BIOLOGY, PRECLINICAL ORGANISMAL MODELS, SYNTHETIC BIOLOGY, ENGINEERING, AND HUMAN TRIALS. THUS, THE MAJOR BENEFITS OF THIS MEETING ARE THE INTEGRATION OF IDEAS AND COLLABORATIVE OUTCOMES ACROSS DISCIPLINES, AS WELL AS CLARITY AND LEADERSHIP FOR STANDARDS IN NAD RESEARCH.

FASEB SRC ON BIOLOGY AND CHEMISTRY OF VISION

THE GASTROINTESTINAL EPITHELIUM CONFERENCE - INTERFACE WITH THE OUTSIDE WORLD - PROJECT SUMMARY/ABSTRACT THIS APPLICATION REQUESTS PARTIAL SUPPORT FOR A FASEB SCIENTIFIC RESEARCH CONFERENCE ENTITLED “GASTROINTESTINAL EPITHELIUM: INTERFACE WITH THE OUTSIDE WORLD” THAT IS SCHEDULED FOR SEPTEMBER 17-21, 2023 IN STEAMBOAT SPRINGS, CO. THE MEETING WILL CONVENE A DIVERSE GROUP OF SPEAKERS, INCLUDING MANY WOMEN, UNDERREPRESENTED MINORITIES, AND YOUNG INVESTIGATORS, TO DISCUSS THE BIOLOGY OF THE GASTROINTESTINAL EPITHELIUM AND ITS ROLE IN HOMEOSTASIS AND DISEASE. THE KEYNOTE PRESENTATIONS PLUS SEVEN LECTURE SESSIONS WILL ADDRESS GASTROINTESTINAL STEM CELL HOMEOSTASIS AND PLASTICITY IN RESPONSE TO INJURY/DISEASE; DEVELOPMENT AND DIFFERENTIATION OF THE EPITHELIUM; INJURY REPAIR, PROLIFERATION, AND REGENERATION IN THE ESOPHAGUS, STOMACH, SMALL INTESTINE, AND COLON; CELL-CELL INTERACTIONS; HOST-PATHOGEN INTERACTIONS; INTESTINAL BARRIER; HYPOXIA, INFLAMMATION AND IBD; AND CANCER. AMPLE TIME WILL BE SET ASIDE FOR DISCUSSIONS AMONGST PARTICIPANTS, AND THE PRESENTATION OF UNPUBLISHED DATA WILL BE PRIORITIZED. THERE WILL ALSO BE TWO POSTER SESSIONS AS WELL AS SEVERAL CAREER DEVELOPMENT ACTIVITIES FOR EARLY CAREER INVESTIGATORS AND TRAINEES, AS WELL AS OPPORTUNITIES TO PROMOTE THE VISIBILITY OF THESE INDIVIDUALS WHO REPRESENT THE FUTURE OF THE FIELD. WE HAVE ASSEMBLED AN INNOVATIVE PROGRAM WITH COMMITTED PARTICIPATION FROM LEADERS WITH DIVERSE EXPERTISE WITHIN GI-RELATED RESEARCH FIELDS. OVERALL, IN AN INTIMATE AND SECLUDED SETTING THAT ENCOURAGES INFORMAL INTERACTIONS BETWEEN SCIENTISTS AT ALL LEVELS, WE PROVIDE AN INNOVATIVE APPROACH TO THE EXCHANGE OF IDEAS AND SYNTHESIS OF SCIENCE THAT WILL MOVE THE FIELD OF GI RESEARCH FORWARD. THE CONFERENCE WILL HAVE HIGH IMPACT AS THE PROGRAM SPANS BASIC SCIENCE DISCOVERY TO CLINICAL SIGNIFICANCE FOR GI HEALTH AND DISEASE. IT IS THEREFORE EXPECTED THAT THE MEETING WILL PROVIDE NEW INSIGHTS NOT ONLY INTO BASIC GASTROINTESTINAL PHYSIOLOGY, NEUROBIOLOGY, DEVELOPMENTAL BIOLOGY AND MICROBIOLOGY, BUT ALSO HOW TO TREAT, AND ULTIMATELY CURE, A WIDE VARIETY OF DIGESTIVE DISEASE STATES.

FASEB SRC ON FOLIC ACID, VITAMIN B12 AND ONE CARBON METABOLISM

FASEB SRC ON

LIVER GROWTH INJURY AND METABOLISM: BASIC AND APPLIED BIOLOGY

2010 FASEB CONFERENCE ON THE RETINOIDS

FASEB'S "THE PROTEIN FOLDING IN THE CELL CONFERENCE"

CELLULAR AND MOLECULAR MECHANISMS OF BRAIN AGING - AGE IS THE GREATEST RISK FACTOR FOR MOST CAUSES OF MORBIDITY IN DEVELOPED NATIONS. RESEARCH INTO THE CELLULAR AND MOLECULAR PROCESSES THAT UNDERLIE AGING AND AGE-RELATED DISEASES IS ESSENTIAL IF SIGNIFICANT IMPROVEMENTS IN HEALTHY AGING ARE TO BE ACCOMPLISHED, INCLUDING INSIGHTS FOR CLINICAL PRACTICE AND FOR NOVEL TREATMENT DEVELOPMENT. THE SCIENCE RESEARCH CONFERENCE (SRC) “CELLULAR AND MOLECULAR MECHANISMS OF BRAIN AGING” IS A PARTNERSHIP BETWEEN THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB) AND THE AMERICAN AGING ASSOCIATION (AGE) AND IS DESIGNED TO PROVIDE A FORUM FOR INVESTIGATORS TO PRESENT AND DISCUSS THE LATEST IN BRAIN AGING RESEARCH. WHILE BOTH AGE AND FASEB PROMOTE DISSEMINATION OF BIOMEDICAL RESEARCH RESULTS, AGE WORKS SPECIFICALLY TO PROMOTE RESEARCH ON THE FUNDAMENTAL PROCESSES OF BIOLOGICAL AGING WITH THE GOALS OF INCREASING THE FUNCTIONAL LIFE OF HUMANS, INFORM THE PUBLIC OF PROGRESS IN AGING RESEARCH, AND EXPAND KNOWLEDGE OF BIOGERONTOLOGY AMONG MEDICAL PROFESSIONALS AND THE LAY PUBLIC. ALONG WITH DISSEMINATING CUTTING-EDGE RESEARCH ON THE MECHANISMS CONTRIBUTING TO BRAIN AGING, ADDITIONAL GOALS OF THIS FASEB/AGE SRC ARE TO PROVIDE A VENUE FOR CAREER ADVANCEMENT FOR EARLY INVESTIGATORS AND TRAINEES, AND TO FOSTER GROWTH OF THE NEUROBIOLOGY OF AGING RESEARCH COMMUNITY. THIS MEETING IS UNIQUE IN THAT IT FOCUSES ON THE NEUROBIOLOGY OF AGING AS DISTINCT FROM BEING FOCUSED ON AGE-RELATED NEURODEGENERATIVE DISEASE, INCLUDES DIVERSE EXPERTISE ON A HOST OF EMERGING TOPICS AND TECHNOLOGIES IN NEUROBIOLOGY, AND INCLUDES KEY FEATURES OF TRANSLATIONAL AND HUMAN RESEARCH, PROVIDING A BLUEPRINT FOR NEW INVESTIGATORS TO FORGE TRANSLATIONAL AVENUES. WE ARE REQUESTING FUNDS TO SUPPORT THE “CELLULAR AND MOLECULAR MECHANISMS OF BRAIN AGING” SRC THAT WILL TAKE PLACE ON SEPTEMBER 15-19, 2024, IN NIAGARA FALLS, NEW YORK. THERE ARE THREE SPECIFIC AIMS. AIM 1: BRING TOGETHER THOUGHT LEADERS/RESEARCHERS IN THE AREA OF CELLULAR AND MOLECULAR MECHANISMS OF BRAIN AGING TO ADVANCE THE FIELD AND ACCELERATE THE PACE OF DISCOVERY; AIM 2: FOSTER CAREER DEVELOPMENT IN THE FIELD OF NEUROBIOLOGY OF AGING, SUPPORTING RECRUITMENT OF NEW IDEAS AND NEW INNOVATION IN THIS GROWING RESEARCH DISCIPLINE; AND AIM 3: RAISE PUBLIC AWARENESS OF AND COMMUNICATE THE VALUE OF NEUROBIOLOGY OF AGING RESEARCH TO A BROADER AUDIENCE. TO ACCOMPLISH THESE AIMS, WE HAVE DESIGNED A PROGRAM THAT FEATURES (I) NEW IDEAS AND EMERGING LEADERS IN NEUROBIOLOGY, (II) A BREADTH OF TOPICS SPANNING MULTIPLE DISCIPLINES THAT CAPTURE THE STATE-OF-THE-ART IN NEUROBIOLOGY OF AGING RESEARCH, (III) CONTRIBUTIONS FROM EARLY CAREER INVESTIGATORS (ECI) (EACH SESSION INCLUDES AT LEAST ONE ECI AND ONE TRAINEE TALK SELECTED FROM ABSTRACTS), (IV) DIVERSITY AMONG THE INVITED AND SELECTED SPEAKERS, AND (V) SPECIFIC OUTREACH TO UNDERREPRESENTED COMMUNITIES TO ENHANCE DIVERSITY AT THE CONFERENCE. THIS UNIQUE CONFERENCE WILL SERVE AS A CRITICAL VENUE FOR EXCHANGING IDEAS, FOSTERING NEW COLLABORATIONS, AND DEVELOPING THE NEXT GENERATION OF RESEARCHERS. IN ADDITION, THIS MEETING WORKS TOWARDS THE GOAL OF TRANSLATING KNOWLEDGE INTO THERAPEUTIC INTERVENTIONS THAT PROMOTE BRAIN HEALTH EVEN INTO ADVANCED AGE.

LUNG EPITHELIUM IN HEALTH AND DISEASE - PROJECT SUMMARY THE 2024 FASEB SUMMER RESEARCH CONFERENCE, "THE LUNG EPITHELIUM IN HEALTH AND DISEASE", IS THE 12TH BIANNUAL CONFERENCE IN THIS AREA, BRINGING TOGETHER DEVELOPMENTAL, CELL AND MOLECULAR BIOLOGISTS, GENETICISTS, PHYSIOLOGISTS, CLINICIANS AND TRANSLATIONAL RESEARCHERS WITH A PRIMARY INTEREST IN LUNG EPITHELIAL BIOLOGY. THE TOPICS SELECTED REPRESENT THE CUTTING-EDGE OF LUNG RESEARCH AND THE PROGRAM IS PLANNED TO DISSEMINATE NEW FINDINGS WITH TRANSLATIONAL POTENTIAL TO ACCELERATE PROGRESS TOWARD NOVEL THERAPIES FOR LUNG DISEASE. TOPICS INCLUDE (1) MOLECULAR MECHANISMS OF LUNG EPITHELIAL DEVELOPMENT, REPAIR/REGENERATION, AND PLASTICITY (2) COMMON AND UNIQUE PATHWAYS OF INTRA-EPITHELIAL COMMUNICATIONS IN LUNG PHYSIOLOGY AND DISEASES, (3) INTERACTIONS BETWEEN LUNG EPITHELIUM AND DISTINCT IMMUNE CELLS, INCLUDING IN THE CONTEXT OF COVID-19 INFECTION (4) CUTTING-EDGE TECHNOLOGIES INCLUDING SINGLE-CELL ANALYSIS APPROACHES AND EX-VIVO MODELS FOR INVESTIGATING LUNG EPITHELIAL BIOLOGY . IN ADDITION TO THE UNIQUE COLLECTION OF RESEARCH TOPICS, THIS MEETING PROVIDES A PLATFORM FOR NEW SPEAKERS, EARLY STAGE INVESTIGATORS, AND TRAINEES. TWENTY-FIVE OF 33 SPEAKERS (55%) HAVE NOT SPOKEN AT THIS CONFERENCE IN THE LAST FOUR YEARS, AND SIXTEEN OF THE 37 SPEAKERS/SESSION CHAIRS (44%) ARE WOMEN. SIXTEEN SHORT-TALK SESSIONS ARE DESIGNATED FOR TRAINEES OR NEW INVESTIGATORS. SPECIFIC EFFORTS ARE BEING MADE TO ENCOURAGE PARTICIPATION BY UNDERREPRESENTED MINORITIES IN THE FIELD. IN ADDITION TO TALKS, THERE ARE 3 POSTER SESSIONS AND 4 “MEET-THE-EXPERTS” SESSIONS TO FACILITATE SCIENTIFIC AND SOCIAL INTERACTIONS BETWEEN ALL PARTICIPANTS. BY BRINGING THE BEST OF THE LUNG EPITHELIUM RESEARCH COMMUNITY TOGETHER, THE OVERALL GOAL OF THIS CONFERENCE IS TO PUSH THE FIELD FORWARD TOWARDS INNOVATIVE DIRECTIONS FOR BASIC RESEARCH AND NOVEL THERAPEUTICS FOR IMPORTANT LUNG DISEASES, INCLUDING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, PULMONARY FIBROSIS, AND BRONCHOPULMONARY DYSPLASIA.

PROTEIN FOLDING IN THE CELL - PROJECT SUMMARY THIS PROPOSAL SEEKS FUNDING FOR 25 EARLY CAREER SCIENTISTS TO ATTEND THE FASEB PROTEIN FOLDING IN THE CELL MEETING IN SOUTHBRIDGE, MA JULY 7-11, 2024. THIS CONFERENCE FOCUSES ON THE LATEST DEVELOPMENTS REGARDING HOW THE NATIVE CONFORMATIONS OF CELLULAR AND SECRETED PROTEINS ARE ACHIEVED AND MAINTAINED, AND WHAT HAPPENS IN THE CELL AND IN MULTICELLULAR ORGANISMS WHEN ABERRANT PROTEIN CONFORMATIONS ARISE, SUCH AS IN ALZHEIMER’S DISEASE AND RELATED DEMENTIAS OF AGING. THE MEETING’S FOCUS IS ON THE BASIC SCIENCE DEFINING PROTEIN HOMEOSTASIS, ENABLED BY ~2500 GENES ENCODING THE PROTEOSTASIS NETWORK, COMPRISING MOLECULAR CHAPERONES AND CO- CHAPERONES THAT MAKE FOLDING VERSUS DEGRADATION DECISIONS. A DECLINE IN PROTEOSTASIS CAPACITY IS ESPECIALLY PROMINENT DURING AGING-ASSOCIATED DISEASE SETTINGS, PARTICULARLY AGE-ASSOCIATED NEURODEGENERATIVE DISEASES. THUS, WE WILL DEDICATE AT LEAST 40% OF THE TALKS TO THIS TOPIC, PAYING PARTICULAR FOCUS ON RECENT ADVANCES IN THERAPEUTIC STRATEGIES. STUDIES IN EXPERIMENTAL MODELS HAVE REVEALED THAT SMALL MOLECULE PROTEOSTASIS REGULATORS MAY BE USEFUL FOR AMELIORATING SOME OF THESE NEURODEGENERATIVE DISEASES. SPECIAL EMPHASIS FOR THE TRANSMISSION OF INFORMATION WILL BE PLACED BOTH ON THE FORMAL PRESENTATIONS AS WELL AS ON INFORMAL INTERACTIONS THROUGH DISCUSSION SESSIONS, WHICH WILL CATALYZE THE GENERATION OF NEW HYPOTHESES AND THE INITIATION OF COLLABORATIONS. AN IMPORTANT GOAL OF THE MEETING IS TO ENABLE EARLY CAREER SCIENTISTS (ECSS) AND UNDERREPRESENTED MINORITY TO SPEAK IN THE MAIN ORAL PRESENTATION VENUE. FOR THIS REASON, A 4-MEMBER DIVERSITY AND INCLUSION TRAINING COMMITTEE (DITC) WAS CREATED, WHO WILL ORGANIZE A ½ DAY PRE-MEETING ENTITLED “FUTURE THOUGHT LEADERS IN CELLULAR PROTEOSTASIS, AGING AND NEURODEGENERATION”. FIFTEEN UNDERREPRESENTED GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS WILL BE INVITED TO SPEAK AT THIS PREMEETING, WHICH WILL BE ATTENDED BY A SIGNIFICANT PROPORTION OF MAIN MEETING SPEAKERS. THREE OF THE BEST PRE-MEETING TALKS WILL BE AWARDED ECS SPEAKING SLOTS IN THE MAIN MEETING. IN ADDITION, WE HAVE ALREADY CONFIRMED AN ADDITIONAL SEVEN ASSISTANT PROFESSORS (SIX FEMALE AND/OR URM) TO SPEAK AT THE MAIN VENUE. MOREOVER, WE OUTLINE A STRATEGY TO ULTIMATELY ACHIEVE A 50:50 RATIO IN FEMALE AND MALE SPEAKERS, INCLUDING AT LEAST 20% URM AND 40% EARLY CAREER SCIENTISTS. FUNDING IS SOUGHT TO PROVIDE REGISTRATION AND TRAVEL AWARDS FOR THE 15 PRE-MEETING SPEAKERS, THE FOUR MEMBERS OF THE DITC AND 6 ECSS SPEAKING AT THE MEETING. AT LEAST 30 POSTER PRESENTERS WILL BE SELECTED TO SHOWCASE THEIR WORK ON THE MAIN STAGE IN FORM OF 2-MIN LIGHTNING TALKS. THUS OVER 65% OF ATTENDEES WILL HAVE THE OPPORTUNITY TO PRESENT THEIR RESEARCH IN FRONT OF THE ENTIRE AUDIENCE. ROUND TABLE DISCUSSIONS AND PANEL SESSIONS OVER LUNCH WILL ENABLE EARLY CAREER SCIENTISTS TO DISCUSS TOPICS LIKE CAREERS, INCLUSION OF UNDERREPRESENTED SCIENTISTS, EFFECTIVE GRANT WRITING, ETC. WITH EXPERTS IN THE FIELD.

FASEB'S MOBILE DNA: EVOLUTION, DIVERSITY, AND IMPACT CONFERENCE. - MOBILE ELEMENTS CONTINUE TO PLAY A MAJOR ROLE IN RESTRUCTURING THEIR HOST GENOMES. SINCE THE DISCOVERY OF TRANSPOSONS, THE MAIN FOCUS HAS BEEN ON THEIR CONTRIBUTION TO GERM LINE DISEASES, WHICH IS PROVEN TO BE RELEVANT TO HUMAN HEALTH. THE MAJOR DEPARTURE OF THE 2021 FASEB CONFERENCE FROM THIS LINE OF THINKING IS ITS FOCUS ON THE TE CONTRIBUTION TO SOMATIC GENETIC VARIATION AND ITS IMPACT ON NORMAL AGING AND AGE-ASSOCIATED DISEASES, SPECIFICALLY THOSE INVOLVING TRANSFORMATION OR DEGENERATION. INTEGRATION OF THIS RESEARCH DIRECTION INTO THE FASEB “MOBILE DNA: EVOLUTION, DIVERSITY, AND IMPACT” MEETING SETS IT APART FROM PREVIOUS FASEB CONFERENCES AS WELL AS OTHER TE- AND AGING-RELATED MEETINGS. THREE MEMBERS OF THE ORGANIZING COMMITTEE, INCLUDING THE ORGANIZER OF THE CONFERENCE, ARE NIA-FUNDED INVESTIGATORS. ONE MEMBER OF THE COMMITTEE, DR. STEVEN AUSTAD, IS A PROMINENT MEMBER OF THE AGING FIELD. FOUR US NATIONAL ACADEMY OF SCIENCES MEMBERS AND TWO MEMBERS OF THE EUROPEAN ACADEMY OF SCIENCES AGREED TO PRESENT AT THE CONFERENCE AND PARTICIPATE IN THE CAREER DEVELOPMENT AND MEET-THE-EXPERT SESSIONS. OUR 2021 FASEB CONFERENCE WAS SCHEDULED FOR JUNE 6-9 IN DUBLIN, IRELAND. HAVING AN INTERNATIONAL LOCATION FOR THE FIRST TIME IN THE HISTORY OF THIS CONFERENCE IS BENEFICIAL BECAUSE BOTH FIELDS ARE STRONG IN EUROPE. THE EUROPEAN LOCATION WILL ALSO MAKE TRAVEL EASIER (I.E. FEWER VISA RESTRICTIONS) AND LESS EXPENSIVE, WHICH WILL INCREASE ATTENDANCE. IN RESPONSE TO COVID THE FASEB HAS CHANGED THE FORMAT TO A 2- DAY VIRTUAL CONFERENCE IN JUNE 8-9, 2021, FOLLOWED BY THE TRADITIONAL ON-SITE CONFERENCE IN JUNE 5-9, 2022. THIS FORMAT IS BENEFICIAL TO OUR GOALS OF ESTABLISHING AND FOSTERING COLLABORATIONS BETWEEN THE TWO FIELDS OF RESEARCH.

EPIGENETICS, CHROMATIN & TRANSCRIPTION

FASEB SRC: THE GASTROINTESTINAL TRACT XIX CONFERENCE: MAKING AND BREAKING A GUT - PROJECT SUMMARY/ABSTRACT THIS APPLICATION REQUESTS PARTIAL SUPPORT FOR A FASEB SCIENTIFIC RESEARCH CONFERENCE ENTITLED “GASTROINTESTINAL TRACT XIX: MAKING AND BREAKING THE GUT” THAT IS SCHEDULED FOR AUGUST 7-12, 2022 IN STEAMBOAT SPRINGS, CO. THE MEETING WILL CONVENE A DIVERSE GROUP OF SPEAKERS, INCLUDING MANY WOMEN, UNDERREPRESENTED MINORITIES AND YOUNG INVESTIGATORS, TO DISCUSS THE BIOLOGY OF THE GASTROINTESTINAL TRACT AND ITS DYSREGULATION IN THE SETTING OF DISEASE. A KEYNOTE ADDRESS PLUS EIGHT LECTURE SESSIONS WILL ADDRESS GASTROINTESTINAL STEM CELL HOMEOSTASIS AND PLASTICITY IN RESPONSE TO INJURY/DISEASE, NUTRITION AND METABOLISM, NOVEL APPROACHES USING GI ORGANOIDS, THE MICROBIOTA-GUT-BRAIN AXIS, EPITHELIAL PHYSIOLOGY, MICROBIAL HOMEOSTASIS AND DISEASE PATHOGENESIS, MUCOSAL INFLAMMATION AND IBD, AND CANCER. AMPLE TIME WILL BE SET ASIDE FOR DISCUSSIONS AMONGST PARTICIPANTS, AND THE PRESENTATION OF UNPUBLISHED DATA WILL BE PRIORITIZED. THERE WILL ALSO BE TWO POSTER SESSIONS AS WELL AS SEVERAL CAREER DEVELOPMENT ACTIVITIES FOR EARLY CAREER INVESTIGATORS AND TRAINEES, AS WELL AS OPPORTUNITIES TO PROMOTE THE VISIBILITY OF THESE INDIVIDUALS WHO REPRESENT THE FUTURE OF THE FIELD. WE HAVE ASSEMBLED AN INNOVATIVE PROGRAM WITH COMMITTED PARTICIPATION FROM LEADERS WITH DIVERSE EXPERTISE WITHIN GI-RELATED RESEARCH FIELDS. OVERALL, IN AN INTIMATE AND SECLUDED SETTING THAT ENCOURAGES INFORMAL INTERACTIONS BETWEEN SCIENTISTS AT ALL LEVELS, WE PROVIDE AN INNOVATIVE APPROACH TO THE EXCHANGE OF IDEAS AND SYNTHESIS OF SCIENCE THAT WILL MOVE THE FIELD OF GI RESEARCH FORWARD. THE CONFERENCE WILL HAVE HIGH IMPACT AS THE PROGRAM SPANS BASIC SCIENCE DISCOVERY TO CLINICAL SIGNIFICANCE FOR GI HEALTH AND DISEASE. IT IS THEREFORE EXPECTED THAT THE MEETING WILL PROVIDE NEW INSIGHTS NOT ONLY INTO BASIC GASTROINTESTINAL PHYSIOLOGY, NEUROBIOLOGY, DEVELOPMENTAL BIOLOGY AND MICROBIOLOGY, BUT ALSO HOW TO TREAT, AND ULTIMATELY CURE, A WIDE VARIETY OF DIGESTIVE DISEASE STATES.

FERROPTOSIS, OXIDATIVE STRESS, AND LIPID METABOLISM - THE INAUGURAL FASEB SUMMER RESEARCH CONFERENCE ON FERROPTOSIS, OXIDATIVE STRESS, AND LIPID METABOLISM WILL COMPREHENSIVELY SURVEY THE RAPIDLY EVOLVING FIELD OF FERROPTOSIS. FERROPTOSIS IS AN IRON-DEPENDENT FORM OF REGULATED CELL DEATH CHARACTERIZED BY OXIDATIVE DAMAGE TO MEMBRANE LIPIDS. CURRENT RESEARCH FOCUSES ON IDENTIFYING NEW SMALL MOLECULE TOOLS AND THERAPEUTICS TO INDUCE AND INHIBIT FERROPTOSIS, DISCOVERING GENETIC REGULATORS OF FERROPTOSIS IN DIFFERENT CELL TYPES AND PATHOLOGICAL CONDITIONS, AND EXPLORING HOW FERROPTOSIS CONTRIBUTES TO NORMAL PHYSIOLOGY AND THE PATHOLOGY OF DISEASES SUCH AS CANCER AND NEURODEGENERATION. THE DISEASE CONNECTIONS AND THERAPEUTIC POTENTIAL OF FERROPTOSIS HAVE GARNERED SIGNIFICANT INTEREST FROM SCIENTISTS IN ACADEMIC AND BIOTECHNOLOGY SECTORS. IT IS THEREFORE IMPORTANT TO HAVE APPROPRIATE FORUMS TO ADVANCE UNDERSTANDING OF FERROPTOSIS AND DISCUSS EMERGING CONTROVERSIES AND CHALLENGES. THIS CONFERENCE WILL TAKE PLACE FROM JULY 27-31, 2025, IN SCOTTSDALE, AZ, AND IS THE FIRST FERROPTOSIS CONFERENCE SERIES IN NORTH AMERICA FOCUSED ON ADVANCING UNDERSTANDING OF FERROPTOSIS. THE CONFERENCE WILL INCLUDE TWO KEYNOTE ADDRESSES FROM LEADERS IN FERROPTOSIS AND OXIDATIVE STRESS: DRS. BRENT STOCKWELL (COLUMBIA UNIVERSITY) AND GINA DENICOLA (MOFFITT CANCER CENTER). THE CONFERENCE WILL FEATURE AN EXCEPTIONAL SPEAKER LINE-UP FOCUSED ON CUTTING-EDGE RESEARCH, INCLUDING SEVEN SESSIONS WITH TALKS BY 21 INVITED SPEAKERS, 4 LATE-BREAKING SPEAKERS, 16 SHORT TALKS SELECTED FROM SUBMITTED ABSTRACTS, 2 POSTER SESSIONS, 20 FLASH TALKS HIGHLIGHTING POSTER PRESENTERS, A CAREER DEVELOPMENT WORKSHOP, AND SEVERAL MEET THE EXPERTS SESSIONS. THE MEETING WILL FOSTER A COLLABORATIVE ENVIRONMENT THROUGH FORMAL INTERACTION MECHANISMS (E.G., “MEET THE EXPERTS” AND NETWORKING SESSIONS), AND EFFORTS TO ENGAGE ATTENDEES IN PROVIDING FEEDBACK ON TALKS AND PRESENTATIONS. THIS MEETING WILL FACILITATE INTERACTIONS ACROSS CAREER STAGES TO ADVANCE SCIENTIFIC COLLABORATION. CONFIRMED SPEAKERS STUDY VARIOUS ASPECTS OF FERROPTOSIS, INCLUDING (BUT NOT LIMITED TO) DEVELOPING SMALL MOLECULE TOOLS AND THERAPEUTICS, UNDERSTANDING BIOCHEMICAL AND CELLULAR MECHANISMS, AND DEFINING CONNECTIONS WITH DISEASE PATHOGENESIS. A CENTRAL GOAL OF THIS CONFERENCE IS TO ENGAGE THE NEXT GENERATION OF SCIENTISTS BY OFFERING OPPORTUNITIES FOR GRADUATE STUDENTS, POSTDOCTORAL FELLOWS, EARLY-CAREER INVESTIGATORS, AND NEWCOMERS TO PARTICIPATE AND PRESENT THEIR WORK. THE CONFERENCE VENUE WAS SELECTED TO FOSTER OPPORTUNITIES FOR BOTH PLANNED AND SPONTANEOUS INFORMAL INTERACTIONS, PROVIDING SCIENTISTS WITH PLATFORMS TO PRESENT RESEARCH, RECEIVE FEEDBACK FROM FIELD LEADERS, AND GAIN CAREER GUIDANCE. DEDICATED EXCLUSIVELY TO THE INVESTIGATION OF FERROPTOSIS AND ITS IMPLICATIONS IN HUMAN DISEASE, THIS INTERNATIONAL CONFERENCE SERVES AS A UNIQUE PLATFORM FOR RESEARCHERS TO EXCHANGE IDEAS AND SHOWCASE PIONEERING DISCOVERIES IN THIS DYNAMIC, RAPIDLY ADVANCING FIELD.

FASEB SRC: THE LUNG EPITHELIUM CONFERENCE: IN HEALTH AND DISEASE - PROJECT SUMMARY THE 2022 FASEB SUMMER RESEARCH CONFERENCE, "THE LUNG EPITHELIUM IN HEALTH AND DISEASE", IS THE 11TH BIANNUAL CONFERENCE IN THIS AREA, BRINGING TOGETHER DEVELOPMENTAL, CELL AND MOLECULAR BIOLOGISTS, GENETICISTS, PHYSIOLOGISTS, CLINICIANS AND TRANSLATIONAL RESEARCHERS WITH A PRIMARY INTEREST IN LUNG EPITHELIAL BIOLOGY. THE TOPICS SELECTED REPRESENT THE CUTTING-EDGE OF LUNG RESEARCH AND THE PROGRAM IS PLANNED TO DISSEMINATE NEW FINDINGS WITH TRANSLATIONAL POTENTIAL TO ACCELERATE PROGRESS TOWARD NOVEL THERAPIES FOR LUNG DISEASE. TOPICS INCLUDE (1) MOLECULAR MECHANISMS OF LUNG EPITHELIAL DEVELOPMENT, REPAIR/REGENERATION, AND PLASTICITY (2) COMMON AND UNIQUE PATHWAYS OF INTRA-EPITHELIAL COMMUNICATIONS IN LUNG PHYSIOLOGY AND DISEASES, (3) INTERACTIONS BETWEEN LUNG EPITHELIUM AND DISTINCT IMMUNE CELLS, INCLUDING IN THE CONTEXT OF COVID-19 INFECTION (4) CUTTING-EDGE TECHNOLOGIES INCLUDING SINGLE-CELL ANALYSIS APPROACHES AND EX-VIVO MODELS FOR INVESTIGATING LUNG EPITHELIAL BIOLOGY . IN ADDITION TO THE UNIQUE COLLECTION OF RESEARCH TOPICS, THIS MEETING PROVIDES A PLATFORM FOR NEW SPEAKERS, EARLY STAGE INVESTIGATORS, AND TRAINEES. TWENTY-THREE OF 33 SPEAKERS (70%) HAVE NOT SPOKEN AT THIS CONFERENCE IN THE LAST FOUR YEARS, AND SIXTEEN OF THE 40 SPEAKERS/SESSION CHAIRS (40%) ARE WOMEN. SIXTEEN SHORT-TALK SESSIONS ARE DESIGNATED FOR TRAINEES OR NEW INVESTIGATORS. SPECIFIC EFFORTS ARE BEING MADE TO ENCOURAGE PARTICIPATION BY UNDERREPRESENT MINORITIES IN THE FIELD. IN ADDITION TO TALKS, THERE ARE 3 POSTER SESSIONS AND 4 “MEET-THE-EXPERTS” SESSIONS TO FACILITATE SCIENTIFIC AND SOCIAL INTERACTIONS BETWEEN ALL PARTICIPANTS. BY BRINGING THE BEST OF THE LUNG EPITHELIUM RESEARCH COMMUNITY TOGETHER, THE OVERALL GOAL OF THIS CONFERENCE IS TO PUSH THE FIELD FORWARD TOWARDS INNOVATIVE DIRECTIONS FOR BASIC RESEARCH AND NOVEL THERAPEUTICS FOR IMPORTANT LUNG DISEASES, INCLUDING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, PULMONARY FIBROSIS, AND BRONCHOPULMONARY DYSPLASIA.

FASEB SRC ON GASTROINTESTINAL TRACT XVIII: INTEGRATED BIOLOGY AND PATHOBIOLOGY OF THE GI SUPER-ORGAN

FASEB SRC ON RETINOIDS

FOLIC ACID VITAMIN B12 AND ONE CARBON METABOLISM

FASEB SRC ON NUTRIENT SENSING AND METABOLIC SIGNALING

VIRUS STRUCTURE AND ASSEMBLY - PROJECT SUMMARY/ABSTRACT “THE VIRUS STRUCTURE AND ASSEMBLY CONFERENCE” IS THE PREMIER INTERNATIONAL MEETING FOR STRUCTURAL VIROLOGY, ATTRACTING HUNDREDS OF RESEARCHERS AT EVERY CAREER LEVEL FROM AROUND THE WORLD. ORGANIZED AS PART OF THE FASEB SCIENCE RESEARCH CONFERENCE SERIES, IT HAS BEEN RUNNING BIENNIALLY SINCE 1990. THE CONFERENCE COVERS A BROAD RANGE OF BACTERIAL AND EUKARYOTIC VIRUSES, WITH AN INITIAL FOCUS ON VIRUS STRUCTURE AND ASSEMBLY PATHWAYS, MECHANISMS OF VIRUS ENTRY, VIRUS-HOST INTERACTIONS, AND VIRAL REPLICATION, RECENTLY EXPANDED TO ENCOMPASS VIRAL GENOMICS AND EVOLUTION, THERAPEUTICS, VACCINES, AND NANOTECHNOLOGICAL APPLICATIONS. A UNIQUE FEATURE OF THE VIRUS STRUCTURE AND ASSEMBLY CONFERENCE HAS BEEN THE ABILITY TO MERGE AND INTEGRATE TREMENDOUS ADVANCES IN BIOPHYSICAL STUDIES OF VIRUSES WITH FUNCTIONAL ASPECTS OF VIRUS BIOLOGY. FUELED BY THE CRYO-ELECTRON MICROSCOPY REVOLUTION, THE FASEB MEETING HAS BROUGHT TOGETHER STRUCTURAL BIOLOGISTS, VIROLOGISTS, AND MICROBIOLOGISTS, PROMOTING INTERACTIONS AND GUIDING YOUNG RESEARCHERS TO EMBRACE STUDIES ON VIRUSES. THE BROAD FOCUS ON VIRUS SYSTEMS STUDIED FROM DIFFERENT ANGLES ENCOURAGES INTER-DISCIPLINARY APPROACHES, STIMULATES COLLABORATIONS, AND SUPPORTS THE RAPID TRANSFER OF TECHNOLOGY, OVERCOMING SILOS AND ROADBLOCKS OF MORE TOPIC-FOCUSED CONFERENCES. TO MAINTAIN ITS LEGACY OF SCIENTIFIC INNOVATION IN VIROLOGY, OUR PROGRAM INCLUDES TOP INVESTIGATORS IN ALL AREAS OF STRUCTURAL VIROLOGY FROM AROUND THE WORLD, MORE THAN ONE-THIRD OF WHOM ARE NEW TO THE CONFERENCE. FOR 2024, WE WILL STRENGTHEN THE FOCUS ON PANDEMIC READINESS WITH AMPLE EXPOSURE TO RNA VIRUSES SUCH AS HIV-1, INFLUENZA, AND SARS-COV-2. A VITAL ASPECT OF THE FASEB VIRUS STRUCTURE AND ASSEMBLY CONFERENCE PEDIGREE IS THE FOCUS ON MENTORING AND TRAINING SESSIONS THAT WE ACHIEVE THROUGH EXTENSIVE SMALL-GROUP ACTIVITIES BETWEEN SENIOR AND JUNIOR RESEARCHERS. SCIENTIFIC DISCUSSIONS WITH SPEAKERS AND AMONG PARTICIPANTS ARE VITAL TO ENCOURAGE THE FLOW OF NEW IDEAS AND NEW COLLABORATIONS, EXPANDING THE BASE AND BRINGING NEW SCIENTISTS TO THE CONFERENCE. IN 2024, WE WILL HAVE FEATURE DAILY “MEET THE EXPERT” SESSIONS AS WELL AS “MEET THE SPONSOR” AND “FLASH TALK” SESSIONS FOR GRADUATE STUDENTS TO PRESENT POSTERS SELECTED BY OUR JUDGES FOR 15-MINUTE PLATFORM TALKS. A RICH “CAREER DEVELOPMENT WORKSHOP” WILL BE OFFERED TO EARLY-STAGE RESEARCHERS WITH GUESTS FROM ACADEMIA, THE PRIVATE SECTOR, AND GOVERNMENT AGENCIES, WHO WILL PRESENT, COMPARE AND CONTRAST ALTERNATIVE CAREER PATHS IN SCIENCE. ALL SESSIONS WILL KEEP A STRONG FOCUS ON WOMEN AND UNDERREPRESENTED GROUPS IN SCIENCE, CREATING AWARENESS AND PROMOTING SCIENTIFIC INCLUSIVENESS. ROBUST FUNDRAISING PRIMARILY MADE POSSIBLE BY OUR SUPER-SPONSOR THERMO SCIENTIFIC AND SUPPORT THROUGH THIS NIH R13 WILL ALLOW US TO OFFER TRAVEL SCHOLARSHIPS TO AN UNPRECEDENTED NUMBER OF GRADUATE STUDENTS, POSTDOCS, AND EARLY-STAGE RESEARCHERS. WHILE CONTINUING THE TRADITION OF TOP-QUALITY FASEB MEETINGS, THE 2024 VIRUS STRUCTURE AND ASSEMBLY CONFERENCE WILL ALSO SUBSTANTIALLY ATTEMPT TO ENLARGE THE SCIENTIFIC BASE AND PROMOTE THE PARTICIPATION OF UNDERREPRESENTED SCIENTISTS.

THE NUTRITIONAL IMMUNOLOGY ACROSS THE LIFESPAN CONFERENCE - ABSTRACT “THE NUTRITION AL IMMUNOLOGY ACROSS THE LIFESPAN CONFERENCE” WAS SELECTED BY FASEB FOR THEIR SCIENCE RESEARCH CONFERENCE (SRC) SERIES AND WILL BE HELD ON JULY 30 – AUGUST 3, 2023, AT THE CROWNE PLAZA HOTEL IN MELBOURNE, FL. THIS IS THE SECOND ITERATION OF THIS CONFERENCE SERIES, WHICH HIGHLIGHTS MECHANISTIC RESEARCH, INCLUDING CLINICAL STUDIES, EXAMINING THE ROLE OF SPECIFIC NUTRIENTS ON IMMUNE FUNCTION AND HOST RESISTANCE. FOR THIS MEETING WE WILL FOCUS ON THE EFFECT OF NUTRITION ON INNATE AND ADAPTIVE IMMUNITY BUT NOW INCLUDE A SPECIAL EMPHASIS ON HOW LIFE STAGE IS AN IMPORTANT DETERMINANT OF NUTRITIONAL REQUIREMENTS AND OUTCOMES. TALKS WILL RANGE FROM BASIC MECHANISMS TO CLINICAL STUDIES AND WILL COVER THEMES RELATED TO NUTRITION AND INFECTION, GUT MICROBIAL HEALTH, INFLAMMAGING, NEONATAL IMMUNITY, AND THE BRAIN-IMMUNITY CONNECTION. TO DATE THERE HAS BEEN A LACK OF ATTENTION TO THE IMPORTANCE OF LIFE STAGE, FROM PRENATAL TO ADVANCED AGE, IN THIS FIELD AND WE SEEK TO ADDRESS THAT GAP WITH THIS CONFERENCE. WE WILL BRING TOGETHER LEADING SCIENTISTS IN THE FIELD TO DRIVE A DISCUSSION ON THIS TOPIC THAT IS HIGHLY TIMELY ACROSS A WIDE RANGE OF DISCIPLINES. IN ADDITION TO HOSTING TALKS BY ESTABLISHED LEADERS IN THE FIELD WE WILL HAVE SEVERAL TALKS BY EARLY CAREER INVESTIGATORS. FURTHER EFFORTS TO SUPPORT CAREER DEVELOPMENT WILL INCLUDE MEET-THE-EXPERT SESSIONS AND CAREER DEVELOPMENT PANEL DISCUSSIONS. IMPORTANTLY, WE HAVE A ROBUST PLAN TO SECURE THE INVOLVEMENT OF INVESTIGATORS FROM DIVERSE AND UNDERREPRESENTED BACKGROUNDS. FUNDRAISING EFFORTS HAVE BEEN FRUITFUL SO FAR, AND WE NOW SEEK TO SUPPLEMENT THOSE FUNDS SO THAT WE CAN BEST SUPPORT THE INVOLVEMENT OF JUNIOR AND MID-CAREER RESEARCHERS. FINALLY, INFORMATION FROM THE MEETING WILL BE DISSEMINATED IN A SPECIAL ISSUE OF A LEADING JOURNAL THAT WILL FEATURE REVIEW ARTICLES FROM THE SPEAKERS.

THE HEMATOLOGIC MALIGNANCIES CONFERENCE - SUMMARY/ABSTRACT THE GOAL OF THIS R13 APPLICATION IS TO PROVIDE PARTIAL SUPPORT TO THE 2023 SCIENTIFIC RESEARCH CONFERENCE ON HEMATOLOGIC MALIGNANCIES ADMINISTERED BY THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB). THIS BIANNUAL CONFERENCE IS THE PREMIER MEETING IN THE FIELD, AND PROVIDES INVALUABLE OPPORTUNITIES FOR EARLY-CAREER SCIENTISTS TO INTERACT WITH PEERS AND LEADING ESTABLISHED INVESTIGATORS IN THE FIELD IN A HIGHLY COLLEGIAL AND INTIMATE SETTING. NUMEROUS ESTABLISHED INVESTIGATORS IN THE FIELD SEE THEIR ATTENDANCE AT THIS CONFERENCE WHEN THEY WERE TRAINEES AS PIVOTAL TO THEIR CAREER DEVELOPMENT, AND THE ABILITY TO HELP CATALYZE THE CAREER DEVELOPMENT OF YOUNG INVESTIGATORS IS A MAJOR DRAW FOR ESTABLISHED SCIENTISTS TO THIS CONFERENCE. THE PROVISIONAL SCIENTIFIC PROGRAM HIGHLIGHTS THE MOST EXCITING SCIENCE AT THE CUTTING EDGE OF DIVERSE SUB-FIELDS OF HEMATOLOGIC MALIGNANCIES OF DEEP INTEREST TO THE SCIENTIFIC COMMUNITY. MAJOR TOPICS INCLUDE 1) MALIGNANT HEMATOPOIETIC STEM CELL BIOLOGY, 2) NORMAL HEMATOPOIETIC DEVELOPMENT, 3) CLONAL HEMATOPOIESIS AND AGING, 4) INFLAMMATION AND HEMATOPOIESIS, 5) THE HEMATOPOIETIC NICHE, 6) REGULATION OF LEUKEMOGENIC GENE EXPRESSION PROGRAMS, 6) METABOLISM AND EPIGENETICS, AND 7) NOVEL THERAPEUTIC STRATEGIES. TWO KEYNOTE LECTURES FROM INTERNATIONALLY RECOGNIZED LEADERS IN THE FIELD BOOKEND THE CONFERENCE. A NUMBER OF PRESENTATION SLOTS ARE SPECIFICALLY DEDICATED TO ORAL PRESENTATIONS BY TO JUNIOR INVESTIGATORS TO BE SELECTED FROM ABSTRACTS. POSTER LIGHTING ROUNDS PROVIDE AN OPPORTUNITY FOR TRAINEES TO INTRODUCE THE AUDIENCE TO THEIR WORK DURING ORAL SESSIONS, AND ENSURE THAT THE POSTER SESSIONS ARE ONE OF THE MOST INTERACTIVE PARTS OF THE CONFERENCE. THE SOLE BUDGETARY REQUEST IN THIS R13 APPLICATION IS FOR 50% SUPPORT OF THE REGISTRATION AND HOUSING COSTS FOR ALL TRAINEES (GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS) WHO WILL PRESENT ORAL OR POSTER PRESENTATIONS AT THIS CONFERENCE.

FASEB SRC ON BIOLOGY AND CHEMISTRY OF VISION

FASEB SRC: THE CONSEQUENCES OF ANEUPLOIDY: HONORING THE CONTRIBUTIONS OF ANGELIKA AMON - ABSTRACT WE ARE REQUESTING GRANT SUPPORT FOR A NEW FASEB CONFERENCE ENTITLED “THE CONSEQUENCES OF ANEUPLOIDY: HONORING THE CONTRIBUTIONS OF ANGELIKA AMON.” THIS CONFERENCE WILL BE HELD FROM SEPTEMBER 11TH TO 16TH, 2022, IN SOUTHBRIDGE, MASSACHUSETTS. THE BROAD GOALS FOR THIS CONFERENCE ARE TWO-FOLD: FIRST, TO BRING TOGETHER THE WORLD’S LEADING EXPERTS IN STUDYING THE CONSEQUENCES OF ANEUPLOIDY, AND SECOND, TO HONOR THE CONTRIBUTIONS OF ANGELIKA AMON, A PIONEER OF ANEUPLOIDY RESEARCH WHO PASSED AWAY FROM OVARIAN CANCER IN 2020. ANEUPLOIDY, OR A CHROMOSOME COPY NUMBER STATE THAT IS NOT A WHOLE-NUMBER MULTIPLE OF AN ORGANISM’S NORMAL HAPLOID COMPLEMENT, IS A HALLMARK OF MALIGNANT GROWTH AND IS THE MOST COMMON GENETIC CAUSE OF INTELLECTUAL DISABILITY. CURRENT SEQUENCING-BASED ESTIMATES SUGGEST THAT UP TO 90% OF HUMAN TUMORS EXHIBIT ANEUPLOIDY, AND HIGH LEVELS OF ANEUPLOIDY ARE ASSOCIATED WITH METASTATIC DISEASE, DRUG RESISTANCE, AND DISMAL PATIENT OUTCOMES. DESPITE THE UBIQUITY OF ANEUPLOIDY IN CANCER AND ITS SIGNIFICANCE TO HUMAN HEALTH, THERE ARE NO REGULAR CONFERENCES IN THE UNITED STATES DEDICATED TO SHARING THE LATEST ADVANCES ON THIS CLASS OF GENOMIC ALTERATIONS. WE AIM TO ESTABLISH A NEW CONFERENCE ON THIS TOPIC THAT WILL SERVE AS A FORUM TO BRING TOGETHER SCIENTISTS TO SHARE THE LATEST ADVANCES IN THIS EXCITING AND FAST-MOVING FIELD. THE ORGANIZING TEAM FOR THIS CONFERENCE CONSISTS OF LEADING ANEUPLOIDY RESEARCHERS WHO WERE ANGELIKA’S COLLEAGUES AND TRAINEES AND ARE CONVENING THIS INAUGURAL CONFERENCE IN HER MEMORY. THIS TEAM HAS ALREADY SECURED THE SUPPORT OF FASEB FOR THIS CONFERENCE, WHICH WILL PROVIDE SIGNIFICANT ORGANIZATIONAL, LOGISTIC, AND TECHNICAL SUPPORT FOR THE EVENT. R13 GRANT FUNDING IS BEING REQUESTED TO SUBSIDIZE THE COSTS FOR EARLY-CAREER RESEARCHERS AND RESEARCHERS FROM UNDER-REPRESENTED BACKGROUNDS TO ATTEND THIS EVENT. WE CURRENTLY HAVE 41 CONFIRMED SPEAKERS ACROSS 10 TOPIC AREAS RELATED TO ANEUPLOIDY AND CHROMOSOME SEGREGATION, WITH A PARTICULAR FOCUS ON THE IMPACT OF ANEUPLOIDY ON TUMOR DEVELOPMENT AND HUMAN HEALTH. ADDITIONAL PROGRAMMING IS PLANNED FOR EARLY-CAREER SCIENTISTS, INCLUDING A SERIES OF SHORT TALKS, TWO POSTER SESSIONS, AND SEVERAL CAREER-DEVELOPMENT EVENTS.

THE 3RD INTERNATIONAL FASEB CONFERENCE ON RETINOIDS

THE CONSEQUENCES OF ANEUPLOIDY - PROJECT SUMMARY/ABSTRACT WE ARE REQUESTING GRANT SUPPORT FOR THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB) CONFERENCE “THE CONSEQUENCES OF ANEUPLOIDY.” IN PARTNERSHIP WITH FASEB, THE NEXT MEETING WILL BE HELD FROM SEPTEMBER 15-19, 2024 IN MELBOURNE, FLORIDA. THE BROAD GOAL OF THE MEETING IS TO BRING TOGETHER A DIVERSE AND CROSS-DISCIPLINARY GROUP OF EXPERTS WHO STUDY ANEUPLOIDY AND ITS IMPACTS ON HUMAN HEALTH. IMPORTANTLY, THIS MEETING FILLS A SUBSTANTIAL GAP FOR THE SCIENTIFIC COMMUNITY BECAUSE THERE IS NO RECURRING CONFERENCE SERIES IN THE UNITED STATES FOCUSED ON THE CONSEQUENCES OF ANEUPLOIDY. OUR LONG-TERM GOAL IS TO DEVELOP THE CONFERENCE INTO A REGULAR MEETING SERIES THAT OCCURS EVERY TWO YEARS. ANEUPLOIDY, AN ABNORMAL NUMBER OF CHROMOSOMES, IS ASSOCIATED WITH MANY HUMAN CONDITIONS AND DISEASES. DURING HUMAN DEVELOPMENT, ANEUPLOIDY IS THE LEADING CAUSE OF MISCARRIAGES AND BIRTH DEFECTS. IN ADDITION, ANEUPLOIDY IS ALSO A HALLMARK OF AGING AND CANCER, OCCURRING IN APPROXIMATELY 85% OF ALL CANCERS. ALTHOUGH RECENT ADVANCES HAVE EXPANDED OUR UNDERSTANDING OF THE CONSEQUENCES OF ANEUPLOIDY, MANY CRITICAL QUESTIONS REMAIN: WHAT ARE THE FATES OF ANEUPLOID CELLS DURING DEVELOPMENT, TUMORIGENESIS, AND AGING? WHAT ARE THE UNIVERSAL VS. CHROMOSOME- OR TISSUE-SPECIFIC PATHOLOGIES ASSOCIATED WITH ANEUPLOIDY? WHAT ARE THE VULNERABILITIES OF ANEUPLOID CELLS? HOW CAN WE THERAPEUTICALLY TARGET ANEUPLOIDY-ASSOCIATED PATHOLOGIES TO DEVELOP MEDICAL REHABILITATION INTERVENTIONS AND HOW CAN WE EXPLOIT THE VULNERABILITIES OF ANEUPLOID CELLS TO SELECTIVELY ELIMINATE THESE CELLS? WE ARE ASSEMBLING THE WORLD’S EXPERTS ON ANEUPLOIDY TO SHARE THEIR LATEST FINDINGS, FOSTER COLLABORATIONS, AND ADVANCE RESEARCH IN THE FIELD. OUR CURRENT PROGRAM AGENDA HAS 34 CONFIRMED MALE AND FEMALE SENIOR AND JUNIOR EXPERTS AND INCLUDES INTERNATIONAL INVESTIGATORS AS WELL AS UNDERREPRESENTED GROUPS. AN ADDITIONAL 19 SPEAKERS WILL BE SELECTED FROM ABSTRACT SUBMISSIONS WITH AN EMPHASIS ON PROVIDING OPPORTUNITIES FOR JUNIOR TRAINEES AND EARLY CAREER INVESTIGATORS TO PRESENT THEIR RESEARCH. FURTHERMORE, THE PROGRAM AGENDA INCLUDES NETWORKING OPPORTUNITIES FOR JUNIOR TRAINEES AND INVESTIGATORS DURING POSTER SESSIONS AND CAREER DEVELOPMENT SESSIONS. CRITICALLY, AN R13 GRANT WILL HELP US TO DEFRAY THE COSTS FOR JUNIOR TRAINEES AND EARLY CAREER INVESTIGATORS TO ATTEND THE MEETING. IN CONCLUSION, A MEETING DEDICATED TO ANEUPLOIDY RESEARCH WILL SUBSTANTIALLY ADVANCE OUR UNDERSTANDING OF HUMAN HEALTH AND DISEASE AND LEAD TO NEW THERAPEUTIC STRATEGIES THAT PREVENT ANEUPLOIDY, ELIMINATE ANEUPLOID CELLS, AND TREAT ANEUPLOIDY ASSOCIATED PATHOLOGIES.

FASEB SRC: THE PHOSPHOLIPIDS CONFERENCE: DYNAMIC LIPID SIGNALING IN HEALTH AND DISEASE - SUMMARY THIS PROPOSAL REQUESTS PARTIAL SUPPORT FOR THE FASEB RESEARCH CONFERENCE “THE PHOSPHOLIPIDS CONFERENCE: DYNAMIC LIPID SIGNALING IN HEALTH AND DISEASE” TO BE HELD JULY 31-AUGUST 5, 2022 AT THE WYNDHAM GRAND JUPITER AT HARBOURSIDE PLACE, JUPITER, FL, USA. THIS CONFERENCE, WHICH BEGAN IN 1988 AND HAS BEEN ATTENDED BIENNIALLY BY RESEARCHERS FROM ACROSS THE WORLD, IS CRITICAL TO THE MISSIONS OF THE NIA BECAUSE LIPIDS ARE CRITICAL MEDIATORS OF SIGNALING, AGING, MITOCHONDRIAL BIOLOGY, METABOLISM, AND NEURODEGENERATION. ALTHOUGH THERE ARE SEVERAL CONFERENCES THAT FOCUS ON LIPID SIGNALING AND METABOLISM, THE PROPOSED 2022 FASEB CONFERENCE WILL HAVE A FOCUS ON LIPIDS AND AGING, LONGEVITY, METABOLISM, AND NEURODEGENERATION. THIS CONFERENCE WILL (1) BRING TOGETHER LEADING INVESTIGATORS IN LIPID METABOLISM AND SIGNALING IN AGING, HEALTH AND LONGEVITY, (2) HELP TRAIN THE NEXT GENERATION OF US INVESTIGATORS TO BRING NEW ADVANCES TO LIPID AND AGING DISCOVERY SCIENCES, AND (3) PROMOTE THE IMPROVEMENT OF HUMAN HEALTH BY INVESTIGATING LIPID METABOLISM AND SIGNALING IN AGING AND LONGEVITY. THE MAJOR GOALS OF THE 2022 FASEB CONFERENCE ON PHOSPHOLIPIDS: DYNAMIC LIPID SIGNALING IN HEALTH AND DISEASE ARE TO: (1) SHARE THE MOST CURRENT INFORMATION ON LIPID METABOLISM AND SIGNALING IN AGING, (2) FACILITATE NEW INTERACTIONS AMONG SCIENTISTS WHO DO NOT NORMALLY INTERACT IN RESEARCH, (3) PROMOTE INTERDISCIPLINARY INTERACTIONS THAT WILL LEAD TO NEW COLLABORATIONS, AND (4) ENABLE UNDERSTANDING AND TRANSLATIONAL RESEARCH LEADING TO SAFE HUMAN INTERVENTIONS TO IMPROVE HEALTHY AGING AND METABOLISM. WE EXPECT THAT THE NEW INSIGHTS THAT ARE FORMED DURING THE COURSE OF THIS MEETING WILL ADVANCE THE ENTIRE LIPID FIELD AND ESPECIALLY A FOCUS ON LIPIDS IN AGING AND NEURODEGENERATION AS WELL AS LONGEVITY, METABOLISM, AND MITOCHONDRIAL BIOLOGY. THE OBJECTIVE OF THIS PROPOSAL IS TO OBTAIN FUNDS TO SUPPORT TRAVEL AND CONFERENCE FEES FOR SCIENTISTS, WITH A SPECIAL EMPHASIS ON JUNIOR FACULTY, TRAINEES, AND THOSE THAT ARE UNDERREPRESENTED IN SCIENCE. THE ORGANIZING COMMITTEE CONSISTS OF FOUR MEMBERS (DRS. STAHELIN, KIGER, BLIND, AND MERIDA), WHO WERE NOMINATED BY THE 2018 FASEB PHOSPHOLIPIDS: DYNAMIC LIPID SIGNALING IN HEALTH AND DISEASE CONFERENCE ORGANIZERS. EACH ORGANIZER IS AN EXPERT IN ONE OR MORE OF THE TOPICS THAT WILL BE COVERED DURING THE COURSE OF THE MEETING. TOGETHER, THE INTERDISCIPLINARY COMMITTEE HAS A BROAD RANGE OF EXPERTISE IN LIPID RESEARCH RELATED TO LIPIDS IN HEALTH AND DISEASE. THE ORGANIZING COMMITTEE HAS MADE CALCULATED EFFORTS TO REPRESENT MAJOR AREAS OF LIPID METABOLISM AND SIGNALING IN AGING, FROM METABOLIC REGULATION TO SPECIFIC AREAS OF BIOLOGY AND DISEASE. A WORKSHOP ON LIPIDS IN AGING AND NEURODEGENERATION WILL ALSO BE HELD, WHICH WE BELIEVE WILL PROVIDE 1) TRAINING ON LIPIDS AND LIPID CHANGES WITH AGING, AS WELL AS 2) NEW OPPORTUNITIES FOR ATTENDEES TO THINK ABOUT THEIR RESEARCH AND HOW IT CAN CROSSOVER INTO THE AGING FIELD.

FASEB SUMMER RESEARCH CONFERENCE ON MOLECULAR BIOPHYSICS OF CELLULAR MEMBRANES

THE THREAT OF EXTREMISM TO MEDICAL RESEARCH: AN INTERNATIONAL SUMMIT

FASEB SRC ON ION CHANNEL REGULATION

FASEB SRC ON THE LUNG EPITHELIUM IN HEALTH AND DISEASE

FASEB SRC ON THE LUNG EPITHELIUM IN HEALTH AND DISEASE

FASEB SUMMER CONFERENCE ON RETINAL NEUROBIOLOGY AND VISUAL PROCESSING

7TH INTERNATIONAL CONFERENCE ON RETINOIDS - PROJECT SUMMARY / ABSTRACT THE SEVENTH INTERNATIONAL CONFERENCE ON RETINOIDS FASEB SRC IS SCHEDULED FOR JULY 7-11, 2024, AT THE RIVERFRONT INTERCONTINENTAL IN ST. PAUL, MN. WITH ORIGINS DATING BACK TO 1982, THIS UNIQUE CONFERENCE CONVENES RESEARCHERS TO EXPLORE BOTH BASIC AND TRANSLATIONAL ASPECTS OF RETINOID BIOLOGY. THE CONFERENCE PROVIDES A PLATFORM TO DISSEMINATE THE LATEST DEVELOPMENTS IN WELL-ESTABLISHED RETINOID RESEARCH AREAS SUCH AS IMMUNITY, DEVELOPMENT, METABOLIC DISORDERS, NUTRITIONAL REGULATION, AND VISUAL DISORDERS. IT WILL ALSO DELVE INTO EMERGING RETINOID APPLICATIONS IN FIELDS LIKE GASTROINTESTINAL ENTEROPATHY, NEURAL PLASTICITY, NEURODEGENERATION, STEM CELL BIOLOGY, AND REGENERATIVE PATHWAYS. THE CONFERENCE WILL PLACE SIGNIFICANT EMPHASIS ON RETINOID THERAPEUTICS, ANALYTICAL TOOLS AND METHODS IN RETINOID RESEARCH, AND NEW DEVELOPMENTS IN THE STRUCTURAL BIOLOGY OF RETINOID ENZYMES AND TRANSPORTERS. THE CLINICAL PORTION OF THE MEETING WILL CENTER ON THE DEVELOPMENT AND APPLICATION OF NOVEL RETINOID AND REXINOID THERAPIES FOR TREATING CANCER, VISUAL AND METABOLIC DISORDERS, AND SKIN AND NEURODEGENERATIVE DISEASES. ATTENDEES WILL BROADEN THEIR UNDERSTANDING OF THE GENETIC AND ENVIRONMENTAL FACTORS IMPACTING THE UPTAKE, METABOLISM, AND BIOLOGICAL RESPONSE TO RETINOIDS. THE CONFERENCE WILL ASSEMBLE INVESTIGATORS AT DIFFERENT STAGES OF THEIR CAREERS AND FROM VARIOUS DISCIPLINES, INCLUDING BIOCHEMISTRY, NUTRITION SCIENCE, CANCER RESEARCH, VISION RESEARCH, STEM CELL BIOLOGY, STRUCTURAL BIOLOGY, IMMUNOLOGY, CHEMISTRY, AND CLINICAL FIELDS. BY PROMOTING COLLABORATION AND INTERDISCIPLINARY DIALOGUE, WE AIM TO ADVANCE UNDERSTANDING AND RESEARCH IN THE RETINOID FIELD. WE WILL HOST CAREER-ORIENTED TRAINING AND MEET-THE-EXPERT SESSIONS TO BENEFIT EARLY-STAGE RESEARCHERS, TRAINEES, POSTDOCTORAL FELLOWS, AND YOUNG INVESTIGATORS. SELECTED ABSTRACTS WILL ALSO BE GIVEN THE OPPORTUNITY FOR ORAL PRESENTATIONS, THEREBY INCREASING THE VISIBILITY OF THESE EMERGING PROFESSIONALS. WE ARE SEEKING PARTIAL FUNDING FOR THE FASEB RETINOID CONFERENCE TO SUSTAIN ITS MISSION, SUPPORT THE ATTENDANCE OF UNDERREPRESENTED AND WOMEN SCIENTISTS, AND FACILITATE THE ENTRY OF EARLY-STAGE INVESTIGATORS INTO THE RETINOID RESEARCH FIELD.

FASEB SRC ON FUNDAMENTAL BIOLOGY AND PATHOPHYSIOLOGY OF THE LIVER

FASEB SRC ON LIVER BIOLOGY: FUNDAMENTAL MECHANISMS AND TRANSLATIONAL APPLICATIONS

POLYCYSTIC KIDNEY DISEASE: BASIC, TRANSLATIONAL, AND CLINICAL SCIENCE

14TH BIENNIAL FASEB SUMMER RESEARCH CONFERENCE ON RETINOIDS

GENETIC RECOMBINATION AND GENOME REARRANGEMENTS - PROJECT SUMMARY/ABSTRACT THIS APPLICATION SEEKS PARTIAL SUPPORT FOR THE FEDERATION OF AMERICAN SOCIETIES OF EXPERIMENTAL BIOLOGY (FASEB) SUMMER RESEARCH CONFERENCE (SRC) ON GENETIC RECOMBINATION AND GENOME REARRANGEMENTS, TO BE HELD JULY 14-19, 2024 IN TUCSON, ARIZONA. THIS WILL BE THE 20TH IN A SERIES OF HIGHLY SUCCESSFUL BIENNIAL CONFERENCES DE- VOTED TO THESE TOPICS. THIS CONFERENCE BRINGS TOGETHER DIVERSE INVESTIGATORS STUDYING BROAD ASPECTS OF GENETIC RECOMBINATION AND GENOME REARRANGEMENTS IN A RANGE OF BIOLOGICAL SYSTEMS AND USING DIFFERENT EXPERIMENTAL APPROACHES. PRESENTATIONS WILL DESCRIBE CUTTING-EDGE UNPUBLISHED WORK ON TIMELY QUESTIONS IN THE FIELD AND WILL FOSTER DISCUSSIONS AMONG PARTICIPANTS AT ALL CAREER STAGES. THIS CONFERENCE WILL PROVIDE UNIQUE OPPORTUNITIES FOR THE OPEN EXCHANGE OF DATA AND TECHNOLOGICAL INNOVATIONS THAT CAN BE ASSIMILATED AND EXPLOITED ACROSS THE ENTIRE FIELD. GENETIC RECOMBINATION COVERS MANY AREAS DIRECTLY RELEVANT FOR UNDERSTANDING THE BIOLOGY OF AGING, CELLULAR SENESCENCE, TELOMERE MAINTENANCE, AND THE ETIOLOGY OF AGING-RELATED DISEASES. HOMOLOGOUS RECOMBINATION IS ESSENTIAL FOR MAINTAINING GENOME STABILITY AND LIMITING GENOME REARRANGEMENTS THAT CAN PROMOTE DISEASE, AND MANY RECOMBINATION PROTEINS ACT AS SUPPRESSORS OF CANCER AND PREMATURE AGING. CONVERSELY, RECOMBINATION MEDIATES PROCESSES PROMOTING DISEASE, INCLUDING COMPLEX GENOME REARRANGEMENTS LEADING TO CANCER AND NEU- ROLOGICAL DISORDERS, FREQUENT CROSSING-OVER ASSOCIATED WITH PREMATURE AGING, AND ALTERNATIVE LENGTHENING OF TELO- MERES (ALT), WHICH ALLOWS CELLS LACKING TELOMERASE TO ESCAPE SENESCENCE. RECOMBINATION PATHWAYS REPAIR DOU- BLE-STRAND DNA BREAKS AND INTER-STRAND CROSSLINKS RESULTING FROM EXPOSURE TO ENVIRONMENTAL STRESSORS SUCH AS GAMMA-RAYS, IONIZING IRRADIATION, ALKYLATING AGENTS, AND UV LIGHT. HENCE UNDERSTANDING RECOMBINATION IS PARA- MOUNT TO UNDERSTANDING THE BIOLOGY OF AGING AND AGING-ASSOCIATED HUMAN DISEASE, INCLUDING THE ROLE OF ENVIRON- MENTAL EXPOSURE. THE FASEB CONFERENCE BRINGS TOGETHER INVESTIGATORS INTERESTED IN GENETIC RECOMBINATION FROM DIVERSE DISCIPLINES, INCLUDING BIOCHEMISTRY, BIOPHYSICS, GENETICS, GENOMICS, AND CELL BIOLOGY. KEY TOPICS TO BE COVERED IN 2024 INCLUDE: (I) THE MOLECULAR MECHANISMS OF RECOMBINATION, (II) MEIOTIC RECOMBINATION, (III) TELOMERE DYNAMICS, AND THE ROLE OF ALT IN ESCAPING SENESCENCE; (IV) COMPLEX GENOME REARRANGEMENTS AND THEIR ROLE IN NEUROLOGICAL DISEASES AND CANCER, (V) REPAIR OF REPLICATION-ASSOCIATED DNA LESIONS, (VI) THE INFLUENCE OF CHROMATIN STRUCTURE ON RECOMBINATION, AND (VII) DNA DAMAGE SIGNALING. SPECIAL EMPHASIS ON THESE TOPICS IS REFLECTED IN OUR INITIAL SPEAKER INVITATIONS. IN ADDITION, ABOUT ONE-THIRD OF PLENARY SESSION TALKS WILL BE SELECTED FROM ABSTRACTS WITH AN EMPHASIS ON LATE-BREAKING ADVANCES FROM UNDERREPRESENTED AND EARLY-STAGE SCIENTISTS. A NUMBER OF INNOVATIONS TO THE CONFERENCE PLAN AND PROGRAM AIM TO FURTHER ENHANCE PARTICIPATION, INTERACTION, EXCHANGE AND DISCUSSION AMONG A DIVERSE GROUP OF PARTICIPANTS; AND INCREASE THE EXPOSURE OF YOUNGER SCIENTISTS. IN SUM, THE FASEB SRC ON GENETIC RECOMBINATION AND GENOME REARRANGEMENTS REMAINS THE MOST IMPORTANT CONFERENCE ON A TOPIC OF THE HIGH INTEREST AND IMPORTANCE TO RESEARCH ON AGE-RELATED DISEASES AND THE SCIENTIFIC COMMUNITY.

FASEB SRC: THE TRANSLATIONAL NEUROIMMUNOLOGY CONFERENCE: FROM BENCH TO BEDSIDE AND BACK - PROJECT SUMMARY THE PURPOSE OF THIS R13 PROPOSAL IS TO SUPPORT THE ATTENDANCE OF TRAINEES, YOUNG INVESTIGATORS, AND INDIVIDUALS HISTORICALLY UNDERREPRESENTED IN SCIENCE AND MEDICINE, AT THE 2022 FASEB CONFERENCE: TRANSLATIONAL NEUROIMMUNOLOGY: FROM BENCH TO BEDSIDE AND BACK. THIS WILL BE THE 15TH BIANNUAL FASEB NEUROIMMUNOLOGY CONFERENCE, THE FIRST HAVING BEEN HELD IN 1988. THE CURRENT MEETING WILL BE HELD AUGUST 29-SEPTEMBER 2, 2022 AT THE RENAISSANCE ASHEVILLE HOTEL IN ASHEVILLE, NORTH CAROLINA. NEUROIMMUNOLOGY IS ONE OF THE FASTEST GROWING FIELDS IN BIOMEDICAL RESEARCH. IT HAS ALSO BEEN ONE OF THE MOST FRUITFUL IN TERMS OF THE SUCCESSFUL TRANSLATION OF WET BENCH DISCOVERIES INTO IMPACTFUL CLINICAL THERAPIES. THE OVERALL INTENT OF THIS CONFERENCE IS TO BRING TOGETHER THE WORLD’S LEADING SCIENTISTS, YOUNG INVESTIGATORS, AND TRAINEES, WHO ARE ENGAGED IN NEUROIMMUNOLOGY RESEARCH FROM A BROAD RANGE OF PERSPECTIVES, IN A COLLEGIAL AND SUPPORTIVE ENVIRONMENT. THE SPECIFIC GOALS ARE TO: 1) PROVIDE A FORUM FOR THE PRESENTATION OF UNPUBLISHED, CUTTING-EDGE RESEARCH ON IMMUNE- NERVOUS SYSTEM INTERACTIONS DURING HEALTH AND DISEASE, BY SPEAKERS FROM DIVERSE BACKGROUNDS; 2) PROVIDE OPPORTUNITIES FOR BOTH FORMAL AND INFORMAL DISCUSSIONS ON NEUROIMMUNE PATHWAYS IN HEALTH AND DISEASE, THE ENVIRONMENTAL AND GENETIC FACTORS THAT INFLUENCE THOSE PATHWAYS, AND EFFORTS TO TRANSLATE SCIENTIFIC INSIGHTS IN NEUROIMMUNOLOGY FROM “BENCH TO BEDSIDE”; 3) SUPPORT THE PARTICIPATION OF YOUNG INVESTIGATORS, PARTICULARLY THOSE TRADITIONALLY UNDER-REPRESENTED IN THE FIELD, AND FACILITATE THEIR INTEGRATION INTO THE BROADER RESEARCH COMMUNITY IN A MEANINGFUL AND INTERACTIVE WAY; (4) PROMOTE PRINCIPLES OF RIGOR, TRANSPARENCY, AND EQUIPOISE IN THE CONDUCT AND EVALUATION OF RESEARCH. THE PROGRAM IS INTENTIONALLY MULTIFACETED TO ENSURE THAT ATTENDEES WORKING ON DIFFERENT ASPECTS OF NEUROIMMUNOLOGY RESEARCH HAVE THE OPPORTUNITY TO MEET COLLEAGUES WITH COMPLEMENTARY INTERESTS AND AREAS OF EXPERTISE, EITHER ONE-ON-ONE OR IN SMALL GROUP SETTINGS. THE AGENDA CONSISTS OF A SERIES OF SEQUENTIAL SESSIONS IN A SINGLE TRACK, WITHOUT COMPETING TALKS, AND UNSCHEDULED AFTERNOON TIME TO ENCOURAGE INFORMAL COMMUNICATIONS. THESE COLLECTIVE FEATURES OF THE CONFERENCE WILL FACILITATE BRAINSTORMING AND MENTORING IN A VARIETY OF FORMATS. A PRIORITY IS TO INSPIRE WOMEN SCIENTISTS, AND LEARNERS AND JUNIOR FACULTY FROM GROUPS THAT ARE TRADITIONALLY UNDERREPRESENTED IN SCIENCE AND MEDICINE, AND TO CONNECT THOSE INDIVIDUALS WITH ROLE MODELS, FUTURE MENTORS, AND PEERS, THEREBY STRENGTHENING THEIR COMMITMENT TO NEUROIMMUNOLOGY RESEARCH. TO THAT END, WE ARE INTRODUCING WORKSHOPS ON “HOW TO FORGE COLLABORATIONS WITH CLINICIANS AND TRANSLATE WET BENCH FINDINGS TO HUMAN STUDIES”; “WOMEN AND UNDER-REPRESENTED MINORITIES IN NEUROIMMUNOLOGY: CHALLENGES AND OPPORTUNITIES”; AND “SCIENTIFIC RIGOR AND TRANSPARENCY IN RESEARCH”, AS WELL AS A CAREER PANEL DISCUSSION ON “CAREER TRAJECTORIES IN NEUROIMMUNOLOGY”. THIS CONFERENCE IS DESIGNED TO FOSTER CREATIVE PARTNERSHIPS AND COLLABORATIONS BETWEEN WET BENCH SCIENTISTS, CLINICAL TRIALISTS/ RESEARCHERS, AND CLINICIANS WHO ARE FOCUSED ON NEUROIMMUNOLOGY, ULTIMATELY LEADING TO CLINICAL ADVANCES IN THE FIELD.

FASEB SRC ON GASTROINTESTINAL TRACT XV: EPITHELIA, MICROBES, INFLAMMATION AND CAN

CONFERENCE: FASEB CONFERENCE ON MECHANISMS IN PLANT DEVELOPMENT -SCIENTIFIC MEETINGS ENABLE THE EXCHANGE OF NEW FINDINGS FROM INTERNATIONAL EXPERTS IN SPECIFIC AREAS OF STATE-OF-THE-ART RESEARCH, WHILE ALSO PROVIDING A FORUM TO ENHANCE THE TRAINING AND NETWORKING OF YOUNGER SCIENTISTS WHO REPRESENT THE FUTURE OF RESEARCH IN THE DISCIPLINE. PLANT DEVELOPMENTAL BIOLOGY IS THE STUDY OF THE PROCESSES WHEREBY PLANTS FORM ALL THE SPECIALIZED CELLS, TISSUES, AND ORGANS OF THE ADULT PLANT, BEGINNING WITH THE FERTILIZATION OF THE SINGLE-CELLED ZYGOTE AND ENCOMPASSING ALL THE SUBSEQUENT STAGES OF DEVELOPMENT INCLUDING EMBRYO FORMATION AND GERMINATION, VEGETATIVE DEVELOPMENT OF LEAVES, ROOTS AND STEMS, AND CULMINATING IN THE FORMATION OF SPORES, SEEDS AND/OR FLOWERS AND FRUITS. THIS NSF AWARD WILL BE USED TO ORGANIZE AN INTERNATIONAL MEETING IN THE AREA OF PLANT DEVELOPMENTAL BIOLOGY, WHICH WILL FEATURE TALKS AND POSTER PRESENTATIONS FROM EXPERTS IN THE FIELD. IN ADDITION, THE MEETING WILL FEATURE TALKS SELECTED FROM YOUNG SCIENTISTS AT EARLY-CAREER STAGES, AND FROM SCIENTISTS FROM UNDER-REPRESENTED GROUPS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS. FURTHERMORE, THE MEETING WILL ALSO HOST INTERACTIVE SESSIONS WHERE YOUNG PLANT DEVELOPMENTAL BIOLOGISTS WILL MEET WITH ESTABLISHED EXPERTS TO DISCUSS STRATEGIES TOWARD ESTABLISHING SUCCESSFUL CAREERS IN SCIENCE. THIS AWARD WILL ENABLE THE ORGANIZATION OF THE 19TH INTERNATIONAL FASEB MECHANISMS IN PLANT DEVELOPMENT, WHICH BRINGS TOGETHER LEADING RESEARCHERS IN WORLD OF PLANT DEVELOPMENTAL BIOLOGY TO EXCHANGE UNPUBLISHED IDEAS AND ADVANCE CONCEPTS IN THE FIELD. LIKEWISE, THE MEETING WILL PROMOTE THE PARTICIPATION AND RECOGNITION OF EARLY-CAREER SCIENTISTS. ACTIVITIES INCLUDE INVITED SPEAKER SESSIONS, EARLY-CAREER SPEAKERS SELECTED FROM ABSTRACTS, MINORITY PARTICIPATION, POSTER SESSIONS, AND CAREER DEVELOPMENT WORKSHOPS. PLANT DEVELOPMENTAL BIOLOGY IS A CORE DISCIPLINE THAT STUDIES SELF-ORGANIZATION OF THE MULTICELLULAR PLANT. DISCOVERIES IN PLANT CELL-TO-CELL SIGNALING, TRANSCRIPTIONAL NETWORKS, AND PHYSIOLOGY ARE RELEVANT TO THE WIDER FIELD OF DEVELOPMENTAL BIOLOGY. NONETHELESS, THERE ARE UNIQUE ASPECTS OF PLANT DEVELOPMENT THAT REQUIRE A DEDICATED MEETING WHERE SCIENTISTS CAN DISCUSS AND EXCHANGE TECHNICAL/CONCEPTUAL INNOVATIONS AND PROVIDE A POINT OF INSPIRATION FOR YOUNG PLANT DEVELOPMENTAL BIOLOGISTS. THIS YEAR?S PROPOSED TOPICS SPAN FOCUS AREAS FOR NSF IOS AND MCB PROGRAMS. THE MEETING PROVIDES A CRITICAL FORUM FOR GRADUATE STUDENTS AND POSTDOCS. THE SMALL SIZE OF THIS MEETING (< 150 PARTICIPANTS) FACILITATES INTERACTION AMONG PARTICIPANTS FROM ALL CAREER STAGES AT MEALS, POSTER SESSIONS, AND ?MEET THE EXPERTS? SESSIONS ADDRESSING CAREER CONCERNS OF YOUNG SCIENTISTS. THIS YEAR?S MEETING WILL FEATURE 14 SHORT TALKS SELECTED PRESENTED BY EARLIER-STAGE RESEARCHERS. PARTICIPATION BY MINORITY AND FEMALE SCIENTISTS IS STRONGLY ENCOURAGED; MORE THAN HALF OF THE INVITED SPEAKERS AT THE CONFERENCE ARE WOMEN. FURTHERMORE, PARTICIPATION OF OTHER UNDERREPRESENTED GROUPS WILL BE AN EMPHASIS OF SHORT-TALK SELECTIONS. THE OUTCOMES OF THE CONFERENCE WILL BE DISSEMINATED THROUGH STUDENT-GENERATED JOURNAL PUBLICATION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

B VITAMINS AND ONE-CARBON METABOLISM IN HEALTH AND DISEASE - PROJECT SUMMARY/ABSTRACT OUR R13 APPLICATION AIMS TO OBTAIN PARTIAL FUNDING FOR THE “B-VITAMINS AND ONE-CARBON METABOLISM IN HEALTH AND DISEASE” CONFERENCE SET TO CONVENE AUGUST 11-16, 2024, IN NIAGARA FALLS, NY. THE MEETING IS PART OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB) SCIENCE RESEARCH CONFERENCE (SRC) SERIES AND CONVENED EVERY 2 YEARS SINCE ITS INCEPTION IN 1986, CELEBRATING ITS 40-TH ANNIVERSARY/20TH MEETING IN 2024. THE IDEA UNDER IT IS TO ASSEMBLE BASIC SCIENTISTS, CLINICIANS, EPIDEMIOLOGISTS, AND PUBLIC HEALTH EXPERTS TO PRESENT AND DISCUSS THE LATEST RESEARCH IN B-VITAMINS AND ONE-CARBON METABOLISM (OCM). IT BRINGS TOGETHER THE MOST PROMINENT EXPERTS IN THE FIELD FROM ALL-OVER THE WORLD AND THE PROMISING YOUNG SCIENTISTS, BOTH STUDENTS AND POSTDOCS. SPECIFIC AIMS OF THE CONFERENCE ARE: 1) ASSEMBLE THE WORLD EXPERTS AND TRAINEES WORKING IN AREAS OF B-VITAMINS AND OCM, TO PRESENT, ANALYZE AND DISCUSS THE MOST RECENT, CUTTING-EDGE RESEARCH, WITH SPECIAL FOCUS ON UNPUBLISHED STUDIES; 2) PROVIDE OPPORTUNITIES FOR STUDENTS, TRAINEES AND INVESTIGATORS THAT ARE NEW TO THIS MEETING TO PRESENT AND DISCUSS THEIR WORK, INTERACT AND RECEIVE FEEDBACK FROM EXPERTS, ESTABLISH COLLABORATIONS AND PROFESSIONAL CONNECTIONS; 3) PROMOTE PARTICIPATION IN THE CONFERENCE BY PROVIDING TRAVEL AWARDS TO STUDENTS AND TRAINEES FOR OUTSTANDING ORAL AND POSTER PRESENTATIONS AND TRAVEL FUNDING ASSISTANCE FOR INVITED SPEAKERS. SCIENTIFIC OBJECTIVES OF THE 2024 MEETING INCLUDE: 1) UPDATE THE EPIDEMIOLOGICAL LANDSCAPE OF THE VITAMINS B DEFICIENCIES AND THEIR LINKS TO MALABSORPTION, INFECTIOUS AND CHRONIC DISEASES, SUCH AS OBESITY AND DIABETES. 2) EVALUATE EVIDENCE OF THE TRANSGENERATIONAL IMPACT OF MATERNAL/PATERNAL OCM AND B-VITAMINS STATUS IN PERI- AND POST-NATAL HEALTH: OBESITY, DIABETES, NEUROLOGICAL/PSYCHIATRIC/DEVELOPMENTAL DISORDERS. 3) REVISE THE SCIENCE AND CLINICAL PRACTICE IN INHERITED METABOLIC DISORDERS OF B-VITAMINS AND OCM FOR DIAGNOSIS, PATHOPHYSIOLOGY, AND TREATMENT ASPECTS. 4) EVALUATE EXPERIMENTAL- AND POPULATION-BASED EVIDENCE OF THE CROSSTALK BETWEEN VITAMINS B/OCM STATUS AND GENOMICS/EPIGENOMICS IN HEALTH AND DISEASE. 5) DISCUSS/COMPARE UTILITY OF CELL AND ANIMAL MODELS IN EXPERIMENTAL STUDIES OF OCM/B-VITAMINS IN HEALTH AND DISEASES. 6) UPDATE OUR KNOWLEDGE ON THE B- VITAMINS AND OCM IN CANCER PREVENTION, PATHOPHYSIOLOGY, AND TREATMENT. 7) ANALYZE THE EXPERIMENTAL- AND POPULATION-BASED EVIDENCE ON THE “TWO SIDES OF THE COIN” ISSUE WITH B-VITAMINS SUPPLEMENTATION/FORTIFICATION. THE ABOVE AIMS WILL BE ACCOMPLISHED OVER 10 SESSIONS INCLUDING THE INVITED SPEAKERS’ PRESENTATIONS AND SHORT TALKS FROM SELECT ABSTRACTS SUBMITTED BY YOUNG SCIENTISTS, TWO POSTER SESSIONS (2 HOURS EACH), “MEET THE EXPERTS” METABOLOMICS WORKSHOP FOR TRAINEES/YOUNG INVESTIGATORS, AND A CAREER-ORIENTED WORKSHOP WITH YOUNG SCIENTISTS DISCUSSING RESEARCH AND PROFESSIONAL DEVELOPMENT WITH SESSION CHAIRS IN SMALL GROUPS. OPPORTUNITIES FOR INFORMAL INTERACTIONS AMONG ATTENDEES ARE FREQUENT DURING THE MEALS, BREAKS, POSTER SESSIONS AND OUTDOOR RECREATIONAL ACTIVITIES. THESE DIRECT PERSONAL INTERACTIONS ENSUE NEW IDEAS, RESEARCH DIRECTIONS/COLLABORATIONS, PROMOTE PROFESSIONAL DEVELOPMENT OF YOUNG INVESTIGATORS, AND ENERGIZE THE FUTURE OF THE FIELD.

FASEB SUMMER RESEARCH CONFERENCE: THE BIOLOGY OF CALPAINS IN HEALTH AND DISEASE

FASEB SRC ON SKELETAL MUSCLE SATELLITE AND STEM CELLS

TRACE ELEMENTS IN BIOLOGY AND MEDICINE - PROJECT SUMMARY THE 2024 FASEB CONFERENCE ON TRACE ELEMENTS IN BIOLOGY AND MEDICINE WILL TAKE PLACE IN MELBOURNE, FLORIDA FROM JUNE 12 – 16, 2024. THIS CONFERENCE, THE 17TH ITERATION OF THIS BIENNIAL MEETING SINCE 1983, IS DESIGNED TO BRING TOGETHER A DIVERSE GROUP OF RESEARCHERS TO SHARE AND DISCUSS THE LATEST FINDINGS IN TRACE ELEMENT RESEARCH. TRACE ELEMENTS SUCH AS IRON, COPPER, ZINC, MANGANESE, AND SELENIUM PLAY CRITICAL ROLES IN BIOLOGY, NUTRITION, AND HEALTH AS ILLUSTRATED BY THE WIDE RANGE OF DISORDERS AND DISEASES ASSOCIATED WITH IMBALANCES IN THESE ESSENTIAL MICRONUTRIENTS. A NOTABLE STRENGTH OF THIS CONFERENCE SERIES HAS BEEN ITS ABILITY TO UNITE BASIC SCIENTISTS FOCUSED ON THE STRUCTURAL AND MOLECULAR DETAILS OF TRACE ELEMENT HOMEOSTASIS IN DIVERSE MODEL SYSTEMS WITH CLINICAL SCIENTISTS/PHYSICIANS STUDYING THE DIRECT IMPACT OF TRACE ELEMENTS ON HUMAN HEALTH, NUTRITION, AND DISEASE, THUS BRIDGING THE GAP BETWEEN BASIC AND APPLIED SCIENCE. BY INTEGRATING MOLECULAR AND BIOMEDICAL RESEARCH, THIS CONFERENCE HAS BEEN HIGHLY SUCCESSFUL IN FOSTERING FRUITFUL COLLABORATIONS ACROSS DISCIPLINES AND IN IDENTIFYING NOVEL SYSTEMS AND APPROACHES TO SOLVE PROBLEMS RELATED TO MICRONUTRIENTS AND HEALTH. THE PROGRAM WILL SPAN A RANGE OF SCIENTIFIC INTERESTS RANGING FROM CELLULAR AND SYSTEMIC TRACE ELEMENT TRANSPORT AND HOMEOSTASIS, TRACE ELEMENTS AND DISEASE, METAL SIGNALING, AND NUTRITIONAL ASPECTS OF TRACE ELEMENTS. THE MEETING ALSO INCLUDES A CAREERS WORKSHOP, A “MEET THE EXPERTS” EVENT, TWO FLASH TALK SESSIONS, AND INFORMAL GROUP ACTIVITIES, WHICH PROVIDE OPPORTUNITIES FOR TRAINEES AND EARLY CAREER INVESTIGATORS TO GAIN ADDITIONAL KNOWLEDGE AND CULTIVATE PROFESSIONAL SKILLS. THE ULTIMATE GOAL OF THIS CONFERENCE SERIES IS TO PROVIDE A FORUM FOR EDUCATION, COLLABORATION, AND INCLUSIVENESS IN ORDER TO FOSTER FURTHER SCIENTIFIC ADVANCEMENTS IN THE ROLE OF TRACE ELEMENTS IN BIOLOGY, HEALTH, AND DISEASE.

FASEB SRC: THE TRACE ELEMENTS IN BIOLOGY AND MEDICINE CONFERENCE - PROJECT SUMMARY THE 2022 FASEB CONFERENCE ON TRACE ELEMENTS IN BIOLOGY AND MEDICINE WILL TAKE PLACE IN ASHEVILLE, NORTH CAROLINA FROM JUNE 12TH TO JUNE 16TH, 2022. THIS CONFERENCE, THE 16TH ITERATION OF THIS BIENNIAL MEETING SINCE 1983, IS DESIGNED TO BRING TOGETHER A DIVERSE GROUP OF RESEARCHERS TO SHARE AND DISCUSS THE LATEST FINDINGS IN TRACE ELEMENT RESEARCH. TRACE ELEMENTS SUCH AS IRON, COPPER, ZINC, MANGANESE, AND SELENIUM PLAY CRITICAL ROLES IN BIOLOGY, NUTRITION, AND HEALTH AS ILLUSTRATED BY THE WIDE RANGE OF DISORDERS AND DISEASES ASSOCIATED WITH IMBALANCES IN THESE ESSENTIAL MICRONUTRIENTS. A NOTABLE STRENGTH OF THIS CONFERENCE SERIES HAS BEEN ITS ABILITY TO UNITE BASIC SCIENTISTS FOCUSED ON THE MOLECULAR DETAILS OF TRACE ELEMENT HOMEOSTASIS IN DIVERSE MODEL SYSTEMS WITH CLINICAL SCIENTISTS/PHYSICIANS STUDYING THE DIRECT IMPACT OF TRACE ELEMENTS ON HUMAN HEALTH, NUTRITION, AND DISEASE, THUS BRIDGING THE GAP BETWEEN BASIC AND APPLIED SCIENCE. BY INTEGRATING MOLECULAR AND BIOMEDICAL RESEARCH, THIS CONFERENCE HAS BEEN HIGHLY SUCCESSFUL IN FOSTERING FRUITFUL COLLABORATIONS ACROSS DISCIPLINES AND IN IDENTIFYING NOVEL SYSTEMS AND APPROACHES TO SOLVE PROBLEMS RELATED TO MICRONUTRIENTS AND HEALTH. THE PROGRAM WILL SPAN A RANGE OF SCIENTIFIC INTERESTS RANGING FROM CELLULAR AND SYSTEMIC TRACE ELEMENT TRANSPORT AND HOMEOSTASIS, TRACE ELEMENTS AND DISEASE, METAL SIGNALING, AND NUTRITIONAL ASPECTS OF TRACE ELEMENTS. THE MEETING ALSO INCLUDES A CAREERS WORKSHOP, A “MEET THE EXPERTS” EVENT, AND A POSTER BLITZ, WHICH PROVIDE OPPORTUNITIES FOR TRAINEES AND EARLY CAREER INVESTIGATORS TO GAIN ADDITIONAL KNOWLEDGE AND CULTIVATE PROFESSIONAL SKILLS. THE ULTIMATE GOAL OF THIS CONFERENCE SERIES IS TO FOSTER THE ONGOING DEVELOPMENT OF NEW THERAPEUTIC TREATMENTS FOR DISORDERS AND DISEASES RELATED TO TRACE ELEMENT METABOLISM.

FASEB SRC ON FOLIC ACID, VITAMIN B12 AND ONE-CARBON METABOLISM

FASEB SRC ON LIVER BIOLOGY: FUNDAMENTAL MECHANISMS AND TRANSLATIONAL APPLICATIONS

FOLIC ACID, VITAMIN B12 AND ONE CARBON METABOLISM

FASEB'S "THE FOLIC ACID, VITAMIN B12 AND ONE-CARBON METABOLISM CONFERENCE"

THE UBIQUITIN SYSTEM: MECHANISMS, FUNCTIONS, AND THERAPEUTICS - PROJECT SUMMARY THE 2026 FASEB SUMMER RESEARCH CONFERENCE (SRC) ON THE UBIQUITIN SYSTEM: MECHANISMS, FUNCTIONS, AND THERAPEUTICS (UB) WILL BE HELD JUNE 1-4, 2026, AT THE GALT HOUSE HOTEL IN LOUISVILLE, KY. THE UB SRC HAS BEEN HELD BIENNIALLY FOR NEARLY FOUR DECADES, SINCE 1989, AND IS THE PREMIER FORUM FOR SHARING AND DISCUSSING THE LATEST DEVELOPMENTS IN UNDERSTANDING THE BASIC BIOLOGY OF PROCESSES REGULATED BY UBIQUITIN AND UBIQUITIN- LIKE (UBL) PROTEINS, AND THERAPEUTIC APPROACHES THAT TARGET OR HARNESS THESE SYSTEMS TO TREAT DISEASE. THIS APPLICATION REQUESTS SUPPORT FOR 12 NEW AND EARLY CAREER INVITED SPEAKERS AND 2 TRAINEE ORGANIZERS OF A PRE- MEETING CAREER FORUM TO ATTEND THE 2026 SRC, WHICH WILL BRING TOGETHER APPROXIMATELY 150 SCIENTISTS AT ALL CAREER STAGES, FROM GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS TO PRINCIPAL INVESTIGATORS, PROFESSORS, AND COMPANY LEADERS WORKING IN ACADEMIA, GOVERNMENT, AND INDUSTRY. REGULATED PROTEIN DEGRADATION THROUGH THE UBIQUITIN-PROTEASOME SYSTEM IS A CRITICAL ASPECT OF PROTEIN HOMEOSTASIS, THE CELL CYCLE, GENE EXPRESSION, METABOLISM, AND DEVELOPMENT. UBIQUITIN AND UBLS ALSO REGULATE A MYRIAD OF OTHER CELLULAR FUNCTIONS, INCLUDING VESICULAR TRAFFICKING, AUTOPHAGY, SIGNAL TRANSDUCTION, AND MEMBRANE PROTEIN BIOGENESIS, VIA NON-DEGRADATIVE MECHANISMS. HENCE, UBIQUITIN AND UBL PATHWAYS IMPACT ESSENTIALLY ALL ASPECTS OF EUKARYOTIC CELL BIOLOGY AND THUS HUMAN HEALTH AND DISEASE, INCLUDING DEVELOPMENTAL, NEUROLOGIC, AND INFLAMMATORY DISORDERS, AS WELL AS CANCERS. THE 2026 UB SRC WILL FEATURE 8 THEMED SESSIONS COVERING A BROAD RANGE OF TOPICS FOCUSED ON UBIQUITIN AND UBL SYSTEMS. THESE SESSIONS WILL INCLUDE 28 INVITED SPEAKERS AND 24 SHORT OR “LIGHTNING” POSTER TALKS THAT WILL BE SELECTED FROM THE SUBMITTED ABSTRACTS. IN ADDITION, FOR THE FIRST TIME, THE 2026 UB SRC WILL CO- LOCATE AND RUN CONCURRENTLY WITH THE FASEB SRC ON PROTEIN FOLDING IN THE CELL (PF), HIGHLIGHTING THE CLOSE CONNECTION BETWEEN PROTEIN BIOGENESIS AND DEGRADATION WHILE ALSO MAXIMIZING COST SAVINGS. THE ORGANIZERS OF THE TWO SRCS HAVE JOINED FORCES TO COORDINATE THE PROGRAMS OF EACH SRC TO MAXIMIZE INTERACTIONS. THIS INCLUDES 3 JOINT SESSIONS, INCLUDING THE OPENING KEYNOTE LECTURES, RUNNING THE POSTER SESSIONS CONCURRENTLY, AND SCHEDULING ALL COFFEE BREAKS, ON-SITE MEALS, AND PANEL AND ROUNDTABLE DISCUSSIONS TO BE HELD TOGETHER. IN ADDITION, THERE WILL BE A JOINT HALF-DAY CAREER FORUM BEFORE THE MAIN SRCS, AIMED AT INTRODUCING TRAINEES TO EACH OTHER, THE SRC ORGANIZERS, AND INVITED SPEAKERS. THIS PRE-MEETING FORUM WILL BE ORGANIZED BY A PEER GROUP OF 4 TRAINEES AND PROVIDES OPPORTUNITIES FOR 16 ADDITIONAL TRAINEES (8 EACH FROM UB AND PF) TO PRESENT THEIR WORK. FINALLY, A NEW OUTREACH COMPONENT WILL BE INTRODUCED TO THE SRC THROUGH THE INVITATION OF LOCAL HIGH SCHOOL STUDENTS TO ATTEND THE POSTER SESSIONS. THUS, IN ADDITION TO UPHOLDING THE LONG-STANDING TRADITION OF THE UB SRC IN FEATURING THE LATEST HIGH-QUALITY WORK FROM BASIC SCIENCE TO TRANSLATION TO THE CLINIC, THESE INNOVATIONS WILL DISTINCTLY ENHANCE AND BROADEN THE UB COMMUNITY TO FOSTER A SAFE, WELCOMING, AND STIMULATING ENVIRONMENT FOR SHARING NASCENT IDEAS AND UNPUBLISHED RESULTS AND FORMING NEW COLLABORATIONS.

FASEB SRC ON TRANSLATIONAL NEUROIMMUNOLOGY: FROM MECHANISMS TO THERAPEUTICS

MITOCHONDRIAL ASSEMBLY AND DYNAMICS IN HEALTH AND DISEASE

FASEB SRC ON THE LUNG EPITHELIUM IN HEALTH AND DISEASE

FASEB SUMMER RESEARCH CONFERENCE TITLED "THE LUNG EPITHELIUM IN HEALTH AND DISEAS

LUNG EPITHELIUM IN DEVELOPMENT AND DISEASE

FASEB SRC ON GASTROINTESTINAL TRACT XVI: GI HOMEOSTASIS, THE MICROBIOME AND THE BARRIER, DEVELOPMENT AND DISEASE.

FASEB SRC ON RETINOIDS

FASEB SRC 2012 ON TRACE ELEMENTS IN BIOLOGY AND MEDICINE

FASEB SRC ON G PROTEIN-COUPLED RECEPTOR KINASES: FROM MOLECULES TO DISEASES.

FASEB SRC ON THE GROWTH HORMONE/PROLACTIN FAMILY IN BIOLOGY AND DISEASE

FASEB SRC ON GASTROINTESTINAL TRACT XVII: CURRENT BIOLOGY OF THE GI TRACT, MUCOSA, MICROBIOTA, AND BEYOND

FASEB SRC ON NUTRITIONAL IMMUNOLOGY: ITS EFFECTS ON HEALTH AND DISEASE.

FASEB'S THE LYSOPHOSPHOLIPID AND RELATED MEDIATORS CONFERENCE: FROM BENCH TO CLINIC - ABSTRACT THE FASEB SCIENCE RESEARCH CONFERENCE ON LYSOPHOSPHOLIPID AND RELATED MEDIATORS: FROM BENCH TO CLINIC WILL BE HELD JULY 11 - JULY 16, 2021 AT THE GRAND HOTEL MALAHIDE, IRELAND. THIS CONFERENCE WILL ADDRESS CURRENT RESEARCH AND EMERGING CONCEPTS RELATED PRIMARILY TO THE LYSOPHOSPHOLIPIDS SPHINGOSINE 1-PHOSPHATE (S1P) AND LYSOPHOSPHATIDIC ACID (LPA) AND THEIR ROLES IN HEALTH AND DISEASE. S1P AND LPA ARE SIGNALING LIPIDS THAT ACTIVATE 5 AND 6 G PROTEIN-COUPLED RECEPTORS, RESPECTIVELY, AND BIND TO INTRACELLULAR TARGET PROTEINS TO REGULATE CELL BIOLOGY. THESE BIOLOGICAL INTERACTIONS CONTROL VITAL FUNCTIONS IN THE CARDIOVASCULAR SYSTEM, THE IMMUNE SYSTEM, AND THE NERVOUS SYSTEM. THESE LIPIDS ARE IMPORTANT IN PULMONARY FIBROSIS, ATHEROSCLEROSIS, CANCER, AUTOIMMUNITY, AND OTHER DISEASE STATES. BOTH RECEPTORS AND ENZYMES REGULATING LYSOPHOSPHOLIPID METABOLISM HAVE BEEN SHOWN TO FUNCTION AS POTENTIAL THERAPEUTIC TARGETS TO DIAGNOSE, PREVENT OR TREAT DISEASE. THE CONFERENCE WILL EMPHASIZE THE TRANSLATION OF THIS WORK INTO CLINICAL PRACTICE AND HIGHLIGHT THE RESEARCH ADVANCES BEING MADE AT A RAPID PACE BY MANY NEW INVESTIGATORS IN THIS FIELD. THE MEETING PROVIDES A UNIQUE AND INVALUABLE FORUM FOR SCIENTISTS FROM DIVERSE DISCIPLINES TO MEET AND DISCUSS THEIR LATEST RESEARCH FINDINGS. THE CONFERENCE AIMS ARE TO 1) PROVIDE INTELLECTUAL EXCHANGE BETWEEN SCIENTISTS AND TRAINEES FROM MULTIPLE DISCIPLINES ENGAGED IN LYSOPHOSPHOLIPID RESEARCH; 2) ENCOURAGE AND FACILITATE ACTIVE DISCUSSION BETWEEN EARLY CAREER AND NEW INVESTIGATORS AND ESTABLISHED SCIENTISTS VIA INTERACTIVE CAREER WORKSHOPS AND MULTIPLE OPPORTUNITIES FOR NETWORKING/COLLABORATION; AND 3) PROVIDE A PLATFORM TO PROMOTE THE PARTICIPATION OF WOMEN AND UNDERREPRESENTED MINORITIES. THE CONFERENCE WILL ALLOW DIVERSE EARLY CAREER AND ESTABLISHED INVESTIGATORS TO COMMUNICATE LATE-BREAKING RESEARCH RESULTS AND PROMOTE FUTURE INTERACTIONS ALIGNED WITH DEVELOPING THERAPIES FOR DISEASES IN WHICH LYSOPHOSPHOLIPIDS PLAY A PREDOMINANT ROLE. THE CONFERENCE SITE IN IRELAND WILL FACILITATE MAXIMUM PARTICIPATION OF EUROPEAN SCIENTISTS, SCIENTISTS FROM OTHER COUNTRIES ABROAD, AND US COUNTERPARTS TO PROMOTE PRODUCTIVE INTERACTIONS FOCUSING ON THE TRANSLATIONAL IMPLICATIONS OF LYSOPHOSPHOLIPIDS.

FASEB SRC ON MOLECULAR, STRUCTURAL & CLINICAL ASPECTS OF VITAMIN K & VITAMIN K-DEPENDENT PROTEINS

FASEB SRC ON CALPAINS IN HEALTH AND DISEASE

FASEB SRC ON FOLIC ACID, VITAMIN B12 AND ONE-CARBON METABOLISM

DNA PALINDROMES:ROLES, CONSEQUENCES AND IMPLICATIONS OF STRUCTURALLY AMBIVALENT D

FASEB SRC: SKELETAL MUSCLE STEM CELLS AND REGENERATION - PROJECT SUMMARY THIS APPLICATION SEEKS PARTIAL SUPPORT FOR THE UPCOMING FEDERATION OF AMERICAN SOCIETIES OF EXPERIMENTAL BIOLOGY (FASEB) CONFERENCE ENTITLED, "SKELETAL MUSCLE STEM CELLS AND REGENERATION", WHICH WILL BE HELD JULY 24-28TH, 2022 IN NEW ORLEANS, LOUISIANA. THIS WILL BE THE 11TH EDITION OF THIS CONFERENCE FOCUSING ON ADULT SKELETAL MUSCLE STEM CELLS (MUSCS) AND THE 10TH SPONSORED BY FASEB. BASED ON ATTENDANCE RECORDS FROM PREVIOUS YEARS, WE EXPECT APPROXIMATELY 175 ATTENDEES FROM AROUND THE WORLD OF WHOM ~50% ARE EXPECTED TO BE WOMEN AND ~60% JUNIOR RESEARCHERS. NO OTHER SCIENTIFIC MEETING HAS A PRIMARY FOCUS ON MUSCS. THE NEED FOR A CONFERENCE WITH THIS FOCUS IS DEMONSTRATED BY THE STEADY INCREASE IN ATTENDANCE SINCE THE MEETING'S INCEPTION AND THE CONSISTENTLY EXCELLENT POST-MEETING EVALUATIONS PROVIDED BY MEETING ATTENDEES. THIS MEETING ATTRACTS ALL LEADING MUSC RESEARCHERS FROM AROUND THE WORLD, FURTHER DEMONSTRATING ITS VALUE FOR ESTABLISHED AND FUTURE LEADERS IN THE FIELD. THE OVERALL OBJECTIVES OF THIS BIENNIAL MEETING INCLUDE: 1) TO PROVIDE A COMPREHENSIVE ANALYSIS OF RECENT DISCOVERIES IN THE FIELD, WITH THE GOAL OF UNDERSTANDING THE REGULATORY MECHANISMS CONTROLLING NORMAL AND ABNORMAL FUNCTIONS OF MUSCS IN MUSCLE HOMEOSTASIS, REGENERATION, HYPERTROPHY, AGING, AND MYOPATHY; 2) TO CREATE AND FOSTER AN INTERACTIVE ENVIRONMENT FOR THE EXCHANGE OF IDEAS AND UNPUBLISHED DATA, SO AS TO HASTEN DISCOVERIES AND FACILITATE NEW AND EXISTING COLLABORATIONS; 3) TO PROVIDE OPPORTUNITIES FOR JUNIOR INVESTIGATORS TO PRESENT THEIR WORK AND NETWORK WITH SENIOR INVESTIGATORS; AND 4) TO FACILITATE CAREER DEVELOPMENT OF WOMEN AND OTHER UNDERREPRESENTED GROUPS BY ENSURING REPRESENTATION IN ALL ASPECTS OF THE CONFERENCE PROGRAM. OUR KEYNOTE SPEAKER WILL BE DR. EDWARD DE ROBERTIS, A PIONEER IN DEVELOPMENT AND STEM CELL BIOLOGY. EIGHT SESSIONS ARE PLANNED, PRESENTING 48 SPEAKERS (24 INVITED SPEAKERS AND AT LEAST 24 SELECTED FROM SUBMITTED ABSTRACTS) AT ALL CAREER LEVELS. SESSION TOPICS INCLUDE: (I) MOLECULAR REGULATION OF MUSCS, (II) STEM CELLS AND REGENERATION IN DISEASED MUSCLE, (III) THE MUSC NICHE AND CELL SIGNALING, (IV) INTERACTION OF MUSCS WITH, AND REGENERATION OF, THE MTJ AND THE NMJ, (V) DYNAMICS OF MUSCLE REGENERATION, (VI) ENGINEERING AND TRANSLATING MUSCS, (VII) MUSCLE HOMEOSTASIS AND REGENERATION IN AGING, (VIII) METABOLISM AND EXERCISE IN MUSCLE REGENERATION. INVITED SPEAKERS HAVE BEEN SELECTED FOR THEIR SCIENTIFIC EXCELLENCE, WITH PARTICULAR ATTENTION TO EQUAL REPRESENTATION OF WOMEN AND MINORITIES AND GEOGRAPHICAL DIVERSITY. SPEAKERS ARE EXPLICITLY REQUIRED TO PRESENT UNPUBLISHED WORK, TO ENSURE SCIENTIFIC DISCUSSION IS AT THE FOREFRONT OF THE FIELD. WE WILL HAVE FOUR POSTER SESSIONS, EACH PRECEDED BY A “POSTERS BLITZ” WHERE SELECTED POSTER PRESENTERS WILL GIVE A ONE-MINUTE TALK TO HIGHLIGHT THEIR WORK; CAREER-ORIENTED WORKSHOPS AND “MEET-THE-EXPERT” BREAKFAST AND LUNCH SESSIONS. THIS MEETING WILL PROVIDE A FORUM TO FOSTER DISCUSSION AND CROSS-FERTILIZATION FROM DIVERSE AREAS OF RESEARCH, TO ADVANCE OUR UNDERSTANDING OF MUSCLE REGENERATION AND HELP IN THE DEVELOPMENT OF THERAPEUTICS.

FASEB SRC ON MOLECULAR MECHANISMS OF IMMUNE CELL DEVELOPMENT AND FUNCTION

TRANSCRIPTION, CHROMATIN, AND EPIGENETICS IN AGING - SUMMARY THE GOAL OF THIS FASEB MEETING “TRANSCRIPTION, CHROMATIN AND EPIGENETICS IN AGING” IS TO COVER INNOVATIVE TOPICS IN THE ROLES EPIGENETIC MECHANISMS PLAY IN THE REGULATION OF AGING AND HOW THIS IS LINKED TO DISEASE STATES. IN THIS MEETING WE WILL COVER BOTH FUNDAMENTAL MECHANISMS AS WELL AS NOVEL THERAPEUTIC STRATEGIES FOR AGE-RELATED DISEASES, INTRODUCING FOR THE FIRST TIME A METABOLISM SESSION AS WELL AS THREE INTERDISCIPLINARY AND THERAPEUTIC- RELATED SESSIONS. EPIGENETIC MECHANISMS ENCOMPASS POST-TRANSLATIONAL MODIFICATIONS OF CHROMATIN AND RNA AS WELL AS TRANSCRIPTIONAL REGULATION, WHICH TOGETHER DEFINE THE TRANSCRIPTIONAL PROGRAM OF THE CELL. THIS FASEB MEETING WILL BE UNIQUE IN INTEGRATING THE LATEST DISCOVERIES IN EPIGENETICS AND THEIR IMPORTANCE IN AGING AS WELL AS ‘NOVEL THERAPEUTIC STRATEGIES FOR AGE-RELATED DISEASES. THERE IS A VITAL NEED FOR SUCH A MEETING, PARTICULARLY IN BRINGING IN TOGETHER SCIENTISTS AT THE FOREFRONT OF BOTH FIELDS, TO DISCUSS INTERDISCIPLINARY APPROACHES TO ADDRESS KEY QUESTIONS IN BOTH FIELDS. EXCITING RECENT STUDIES HAVE REVEALED HOW ORGANISMAL AND CELLULAR AGING CAN BE REGULATED BY EPIGENETIC MECHANISMS, AND HOW THIS IS LINK TO THE METABOLIC STATE OF THE CELL AND ITS MICROENVIRONMENT. THE FIELD OF EPIGENETIC IS RAPIDLY EXPANDING, AND THE AGING FIELD CAN BENEFIT FROM THE LATEST DISCOVERIES AND ADVANCES IN TECHNOLOGIES IN THIS AREA. CONVERSELY, CHALLENGES AND QUESTIONS ABOUT THE ROLE OF EPIGENETICS IN AGING AND AGE-RELATED DISEASES ABOUND, AND IT IS CRITICAL FOR RESEARCHERS IN THE CHROMATIN AND TRANSCRIPTION FIELDS TO BETTER GRASP THE IMPLICATIONS OF THEIR WORK FOR HEALTH AND DISEASE. THIS FASEB MEETING WILL DISCUSS CUTTING-EDGE QUESTIONS IN FIELD FOCUSING ON THE KEY TOPIC OF THE UNDERLYING MOLECULAR MECHANISMS THAT GOVERN EPIGENETIC REGULATION IN AGING. THE MEETING WILL COVER NEW FRONTIERS, INCLUDING THE EXCITING EMERGING FIELD OF RNA EPIGENOMICS AND NEW INTERDISCIPLINARY CHEMICAL-BIOLOGY APPROACHES TO STUDY THESE. THE MEETING WILL PARTICULARLY FOCUS ON TRANSFORMATIVE EPIGENOMIC TECHNOLOGIES INCLUDING THE DEVELOPMENT AND UTILITY OF NEW CHEMICAL MODALITIES TO MANIPULATE AND EVENTUALLY TARGET THESE FOR THERAPEUTICS. THIS MEETING WILL FOSTER EXCITING INTERACTIONS BETWEEN SCIENTISTS ADDRESSING FUNDAMENTAL QUESTIONS, DEVELOPING NEW METHODOLOGIES AND THERAPEUTIC MODALITIES. THE MEETING WILL ALSO PROVIDE A UNIQUELY INTERACTIVE, DIVERSE, AND INCLUSIVE FORUM THROUGHOUT THE MEETING THROUGH SHORT TALKS, POSTER TEASERS AND SESSIONS AND PROMOTING SEVERAL NETWORKING AND MEET-THE-EXPERT EVENTS. TO FURTHER ENHANCE OUR SUPPORT OF THE NEXT GENERATION OF SCIENTIST, WE ESTABLISHED FOR THE FIRST TIME A FULL DAY OF FASEB-JUNIOR SECTION THAT IS DEDICATED TO CAREER-DEVELOPMENT AND NETWORKING FOR TRAINEES AND NEW INVESTIGATORS. BRINGING THESE YOUNG INVESTIGATORS AT EARLY STAGES OF THEIR CAREER WILL NOT ONLY ENCOURAGE THEM TO WORK IN THIS FIELD BUT ALSO FOSTER LONG-TERM INTERDISCIPLINARY COLLABORATIONS IN VERY DIFFERENT AREAS THAT WILL BE HIGHLY BENEFICIAL FOR BOTH FIELDS.

FASEB SRC ON THE BIOLOGY OF CALPAINS IN HEALTH AND DISEASE

MOLECULAR METABOLISM: FROM CELL BIOLOGY TO SYSTEMS PHYSIOLOGY - PROJECT SUMMARY/ABSTRACT JEFFREY ELMENDORF, DAVID GUERTIN AND KATHRYN WELLEN ARE PLEASED TO CO-CHAIR THE NEXT FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB) CONFERENCE ON “MOLECULAR METABOLISM: FROM CELL BIOLOGY TO SYSTEMS PHYSIOLOGY.” THE EVENT WILL BE HELD AT SOUTHBRIDGE HOTEL & CONFERENCE CENTER SOUTHBRIDGE, MA, DURING THE WEEK OF JULY 14-18, 2024. THIS MARKS A NEW VENUE AND AN EXPANDED THEME FOR ONE OF THE LONGEST- RUNNING AND BEST-REGARDED MEETINGS IN THE FASEB SRC SERIES, HISTORICALLY FOCUSED ON GLUCOSE TRANSPORTERS, INSULIN SIGNALING AND GLUCOSE HOMEOSTASIS. THE CONFERENCE WAS ORIGINALLY LAUNCHED IN 1993 IN RECOGNITION OF THE CLONING AND CHARACTERIZATION OF A SUBSET OF THE MAJOR GLUCOSE TRANSPORTER ISOFORMS. OVER THE ENSUING YEARS, THE MEETING HAS CONTINUED TO FEATURE IMPORTANT ADVANCES IN GLUCOSE REGULATION, EVOLVING IN RECENT MEETINGS TO EMBRACE NEW TOPICS IN GLUCOSE HOMEOSTASIS, METABOLITE SIGNALING, AND SYSTEMS PHYSIOLOGY AS THEY RELATE TO CHRONIC DISEASES AND CONDITIONS INCLUDING OBESITY, DIABETES, AND CARDIOVASCULAR DISEASES. OUR 2024 CONFERENCE WILL HIGHLIGHT NEWLY DISCOVERED MECHANISMS OF METABOLIC REGULATION AND DYSREGULATION AT BOTH THE CELL AND ORGAN LEVEL. THE THEMES OF THE MEETING WERE ALSO CHOSEN TO ALIGN WITH CHALLENGES FACED BY THE PHARMACEUTICAL AND BIOTECH INDUSTRIES IN IDENTIFYING NEW THERAPEUTIC TARGETS THAT COMBAT TRACTABLE DISEASE MECHANISMS. FOR EXAMPLE, THE CONFERENCE WILL SHINE A SPOTLIGHT ON BASIC, CLINICAL, AND PHARMACEUTICAL SCIENCE BEHIND BENCH-TO-BESIDE ASPECTS OF DRUG DEVELOPMENT, AS WELL AS ON BREAKTHROUGH ADVANCES IN THE METABOLIC RELATIONSHIPS BETWEEN VARIOUS DISEASES. A PARTICULAR EXAMPLE WILL BE A SESSION CENTERED AROUND GLP1-BASED THERAPIES TO INSPIRE BOTH YOUNG AND ESTABLISHED, INVESTIGATORS TO FORGE AHEAD WITH STUDIES AIMED AT DISEASE PREVENTION AND TREATMENT AVENUES. IMPORTANTLY, THIS AND OTHER SESSIONS HAVE BEEN DESIGNED WITH THE GOALS OF ATTRACTING YOUNG INVESTIGATORS AND IN MAINTAINING AN INCLUSIVE CONFERENCE ENVIRONMENT BY WHICH TRAINEES AND ESTABLISHED INVESTIGATORS OF ALL CULTURAL BACKGROUNDS AND PERSONAL CHARACTERISTICS CAN BENEFIT. WE HAVE INVITED 32 SCIENTISTS FROM INSTITUTIONS AND COMPANIES WORLDWIDE TO SPEAK AT THE MEETING, AS WELL AS AN ADDITIONAL DOZEN PROMINENT SCIENTISTS TO SERVE AS SESSION CHAIRS AND DISCUSSION LEADERS. IN ADDITION TO THESE SPEAKERS WE WILL BE SELECTING APPROXIMATELY 16 SHORT TALKS FROM ABSTRACTS TO BE PRESENTED BY JUNIOR INVESTIGATORS, POSTDOCTORAL FELLOWS, AND STUDENTS. WE WILL ALSO RUN SEVERAL POSTER SESSIONS, AND CONTINUE TWO VERY WELL- RECEIVED EVENTS LAUNCHED AT PREVIOUS MEETINGS; A "SPEED-DATING" SESSION TO FACILITATE NETWORKING AND ENCOURAGE STUDENT PARTICIPATION FROM THE VERY BEGINNING OF THE MEETING; AND AN “OPEN MIKE” SESSION OF APPROXIMATELY 2 HOURS TO ALLOW VOLUNTEERS TO PRESENT PARTICULARLY EXCITING DATA FOR DISCUSSION, WITH ABOUT 10 MINUTES PER SPEAKER. WE WILL ALSO HOLD A CAREER DEVELOPMENT WORKSHOP FOCUSING ON THE USE OF SOCIAL MEDIA PLATFORMS IN SCIENCE.

FASEB SRC ON TRACE ELEMENTS IN BIOLOGY AND MEDICINE

FASEB SRC ON GASTROINTESTINAL TRACT XIV: STEM CELLS, ADAPTATION, INFLAMMATION AND

FASEB SRC ON NAD+ METABOLISM & SIGNALING

MECHANOBIOLOGY OF THE NUCLEUS - THE NUCLEUS IS THE DEFINING FEATURE OF EUKARYOTIC CELLS AND HOUSES THE CELL’S GENETIC INFORMATION. WHEREAS CURRENTLY SUBSTANTIAL EFFORTS AND ROBUST COMMUNITIES OF RESEARCHERS EXIST THAT FOCUS ON THE GENETIC SEQUENCES CONTAINED IN THE NUCLEUS AND RELATED BIOCHEMICAL PROCESSES (E.G., DNA REPLICATION AND TRANSCRIPTION), IT IS INCREASINGLY RECOGNIZED THAT THE PHYSICAL PROPERTIES OF THE NUCLEUS, INCLUDING ITS SIZE, STIFFNESS, AND THE THREE-DIMENSIONAL ORGANIZATION OF THE NUCLEAR CONTENT, PLAY CRITICAL ROLES IN DEFINING NUCLEAR AND CELLULAR FUNCTION. IN ADDITION, A RAPIDLY GROWING BODY OF RESEARCH INDICATES THAT PHYSICAL FORCES EXERTED ON THE NUCLEUS MODULATE NUCLEAR STRUCTURE AND FUNCTION, AND THEREBY INFLUENCE CELL FATE AND DECISION-MAKING, ALTHOUGH THE UNDERLYING MECHANICS REMAIN LARGELY UNCLEAR. THIS ‘NUCLEAR MECHANOBIOLOGY’ IS NOW RECOGNIZED TO PLAY IMPORTANT ROLES IN TISSUE DEVELOPMENT, HOMEOSTASIS AND VARIOUS DISEASES, INCLUDING MUSCULAR DYSTROPHY, HEART DISEASE, SKIN DISEASE, AND CANCER. DESPITE THE GREAT THERAPEUTIC PROMISE OF LEVERAGING THESE INSIGHTS TO TACKLE THESE DISEASES, MANY FUNDAMENTAL QUESTIONS REMAIN REGARDING BOTH THE PHYSIOLOGICAL AND PATHOLOGICAL ROLES OF NUCLEAR MECHANOBIOLOGY. ANSWERING THESE QUESTIONS WILL REQUIRE MULTIDISCIPLINARY APPROACHES AND COLLABORATION BETWEEN BIOLOGISTS, BIOPHYSICISTS, BIOMEDICAL ENGINEERS, PHYSICISTS, AND MATHEMATICAL/COMPUTATIONAL MODELERS. TOWARDS THIS GOAL, THIS APPLICATION REQUESTS FUNDS TO SUPPORT A “MECHANOBIOLOGY OF THE NUCLEUS” CONFERENCE ORGANIZED THROUGH THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB) SCIENCE RESEARCH CONFERENCE FRAMEWORK, WHICH WILL TAKE PLACE IN MELBOURNE, FLORIDA, OCTOBER 26-31, 2025. THIS WILL BE THE FIRST EVER RESEARCH CONFERENCE DEDICATED SPECIFICALLY TO NUCLEAR MECHANOBIOLOGY WITH APPLICATIONS ACROSS CELLULAR FUNCTIONS AND DISEASE. WE REQUEST FUNDS TO COVER REGISTRATION FOR STUDENTS, POSTDOCTORAL RESEARCHERS, AND EARLY-CAREER FACULTY TO DEFRAY TRAVEL COSTS FOR DOMESTIC PARTICIPANTS AS WELL AS TO PROVIDE FAMILY CARE AWARDS. THE MEETING WILL PROVIDE A UNIQUE FORUM TO DISCUSS THE MOST RECENT ADVANCES IN UNDERSTANDING THE ROLE OF MECHANICAL FORCES IN MODULATING CELLULAR DECISION-MAKING BY ALTERING NUCLEAR AND CHROMATIN BIOPHYSICS AND THE ROLE THESE PROCESSES PLAY IN FUNDAMENTAL CELL BIOLOGICAL PROCESSES (E.G., MIGRATION, DIFFERENTIATION, DEVELOPMENT) AND DISEASE PATHOGENESIS. WE HAVE ORGANIZED A STIMULATING PROGRAM OF SCIENTIFIC SESSIONS IN AN ENVIRONMENT THAT IS CONDUCIVE TO INTERACTIVE DISCUSSION AND DISCOURSE AMONG A COMMUNITY OF BOTH ESTABLISHED INVESTIGATORS AND JUNIOR SCIENTISTS REPRESENTING MULTIPLE DISCIPLINES. AIM 1 IS TO PROVIDE AN INTERDISCIPLINARY FORUM AND TO CREATE A SCIENTIFIC NETWORK CENTERED ON NUCLEAR MECHANOBIOLOGY AND ITS ROLE IN CELLULAR FUNCTIONS AND DISEASE. AIM 2 IS TO HIGHLIGHT NOVEL SCIENTIFIC THEMES AND CUTTING-EDGE RESEARCH TOOLS FOR NUCLEAR MECHANOBIOLOGY THROUGH SESSIONS LED BY LEADERS IN THE FIELD AND RELEVANT TALKS BY INVESTIGATORS OUTSIDE THE FIELD. AIM 3 IS TO FOSTER THE ENGAGEMENT AND FUTURE SUCCESS OF EARLY CAREER SCIENTISTS IN THIS NASCENT FIELD TO EMPOWER THE NEXT GENERATION OF LEADERS IN NUCLEAR MECHANOBIOLOGY.

MOLECULAR, STRUCTURAL & CLINICAL ASPECTS OF VITAMIN K-DEPENDENT PROTEINS

FASEB SRC ON TRACE ELEMENTS IN BIOLOGY AND MEDICINE

CHANNELS AND TRANSPORTERS IN IMMUNITY - SUMMARY THIS PROPOSAL REQUESTS FUNDS TO SUPPORT THE FASEB SCIENCE RESEARCH CONFERENCE (SRC) ON "CHANNELS AND TRANSPORTERS IN IMMUNITY" (CTI) THAT WILL BE HELD FROM JUNE 14–20, 2024 IN ST. PAUL, MN. FASEB SRCS ARE ONE OF THE LEADING CONFERENCE SERIES THAT BRING TOGETHER SCIENTISTS FROM ALL OVER THE WORLD WHO ARE EXPERTS IN A SPECIFIC RESEARCH AREA TO PRESENT AND DISCUSS THEIR LATEST AND MOST IMPORTANT RESEARCH. THIS WILL BE THE FIRST FASEB SRC ON THIS PARTICULAR TOPIC AND THE MOST SIGNIFICANT MEETING OF THE YEAR ON THIS TOPIC. THE ONLY OTHER MULTI-DAY CONFERENCE IN THE CTI FIELD TOOK PLACE IN 2021 AND WAS ATTENDED BY MORE THAN 150 PARTICIPANTS, BOTH VIRTUALLY AND IN PERSON. THE CURRENT FASEB CONFERENCE, ORGANIZED BY THE SAME TEAM, BUILDS ON THE SUCCESS OF THE 2021 MEETING AND AIMS AT ESTABLISHING A RECURRING VENUE FOR SCIENTISTS IN THE FIELDS OF IMMUNOLOGY, PHYSIOLOGY, BIOPHYSICS, STRUCTURAL BIOLOGY AND CELL BIOLOGY. EFFECTIVE IMMUNE RESPONSES TO INFECTION OR TISSUE DAMAGE RELY ON THE ABILITY OF IMMUNE CELLS TO RAPIDLY RESPOND TO STIMULI. SEVERAL CHANNELS AND TRANSPORTERS (C&TS) HAVE EMERGED TO BE IMPORTANT CONTROL SWITCHES THAT SHAPE IMMUNOLOGICAL AND INFLAMMATORY RESPONSES DURING INFECTION, CANCER AND AUTOIMMUNITY. MUTATIONS IN SOME OF THESE CHANNELS HAVE BEEN LINKED TO IMMUNODEFICIENCY IN RARE POPULATIONS OF HUMAN PATIENTS. NEVERTHELESS, WE KNOW VERY LITTLE ABOUT THE FUNCTION OF THE VAST MAJORITY OF THE HUNDREDS OF C&TS THAT ARE EXPRESSED IN IMMUNE CELLS. MAJOR GAPS IN OUR CURRENT KNOWLEDGE INCLUDE A MECHANISTIC UNDERSTANDING OF HOW ION FLUXES REGULATE IMMUNE RESPONSES AT THE CELLULAR AND ORGANISMAL LEVEL. THIS IS A CLEARLY MISSED OPPORTUNITY FOR OUR BASIC UNDERSTANDING OF IMMUNOLOGY AS WELL AS ITS CLINICAL APPLICATIONS. AS A RESULT, THERE ARE CURRENTLY NO FDA–APPROVED DRUGS TARGETING C&TS FOR IMMUNOLOGICAL DISORDERS. CLINICAL AREAS THAT WOULD BENEFIT FROM A BETTER UNDERSTANDING OF THE ROLE OF ICTS IN IMMUNE CELLS INCLUDE ASTHMA/ALLERGY, AUTOIMMUNE DISEASES, ANTITUMOR IMMUNITY AND IMMUNITY TO INFECTION. THE FASEB SRC ON "CHANNELS AND TRANSPORTERS IN IMMUNITY" WILL PROVIDE A UNIQUE AND NOVEL OPPORTUNITY FOR SCIENTISTS FROM DIFFERENT FIELDS THAT TYPICALLY DO NOT INTERACT TO DISCUSS THE LATEST ADVANCES IN THE REGULATION, FUNCTION AND PHYSIOLOGICAL ROLES OF ICTS IN INNATE AND ADAPTIVE IMMUNITY. THE PURPOSE OF THIS CONFERENCE THEREFORE IS NOTHING LESS THAN TO INVIGORATE THE ENTIRE FIELD OF C&TS IN IMMUNOLOGY AND TO IGNITE BROAD INTEREST AMONG ACADEMIC LABS AND PHARMACEUTICAL COMPANIES TO DEVELOP DRUGS TARGETING C&TS FOR THE TREATMENT OF IMMUNOLOGICAL DISEASES. THE SPECIFIC AIMS OF THE SYMPOSIUM ARE TO (1) DISCUSS CUTTING-EDGE SCIENCE IN THE ION CHANNEL AND IMMUNOLOGY FIELDS AND PROMOTE OPPORTUNITIES FOR NEW INTERDISCIPLINARY COLLABORATIONS; (2) FACILITATE THE TRANSLATION OF BASIC KNOWLEDGE INTO PRE-CLINICAL EXPLORATIONS AND CLINICAL INITIATIVES; (3) PROVIDE PRESENTATION, NETWORKING AND CAREER- DEVELOPMENT OPPORTUNITIES FOR TRAINEES INCLUDING STUDENTS, POSTDOCS AND JUNIOR FACULTY; AND (4) INCREASE THE NUMBER OF WOMEN, UNDER-REPRESENTED MINORITIES (URMS) AND DISABLED INDIVIDUALS IN THIS FIELD.

FASEB'S "THE LIVER BIOLOGY CONFERENCE: FUNDAMENTAL MECHANISMS AND TRANSLATIONAL APPLICATIONS"

FASEB SRC: THE BIOLOGY OF CALPAINS IN HEALTH AND DISEASE - SUMMARY THIS R13 PROPOSAL IS BEING SOLICITED TO PROVIDE PARTIAL SUPPORT FOR A FASEB SUMMER RESEARCH CONFERENCE ON “THE BIOLOGY OF CALPAINS IN HEALTH AND DISEASES”. THIS CONFERENCE HAS BECOME A VITAL MEANS FOR CALPAIN RESEARCHERS FROM DIFFERENT DISCIPLINES TO MEET AND EXCHANGE UNPUBLISHED DATA AND EXPERTISE. THROUGH THESE CONFERENCES (WHICH OCCUR EVERY THREE YEARS), PRODUCTIVE COLLABORATIONS BETWEEN CALPAIN-FOCUSED INVESTIGATORS, CLINICIANS AND INDUSTRY HAVE BEEN FACILITATED, DUE TO INCREASED INTERACTION AND EXPOSURE, WHICH ARE FOSTERED BY THE FASEB SRC VENUES. THE MEETING HAS PROVIDED AN INTELLECTUALLY ENGAGING FORUM FOR INFORMATION EXCHANGE PRIOR TO PUBLICATION AND HAS ALLOWED FACULTY AND THEIR TRAINEES TO LEARN ABOUT EMERGING RESEARCH AND THE AVAILABILITY OF RARE RESOURCES AND REAGENTS. THESE OPPORTUNITIES EFFECTIVELY INCREASE THE INTEREST IN CALPAIN RESEARCH, ATTRACT YOUNG INVESTIGATORS AND PROPEL NEW DISCOVERIES. CALPAINS COMPRISE A LARGE FAMILY OF PROTEASES THAT ARE TREMENDOUSLY CONSERVED AMONGST SPECIES AND ARE UBIQUITOUSLY DISTRIBUTED IN TISSUES. SINCE THEIR DISCOVERY, THERE HAS BEEN REMARKABLE PROGRESS IN UNDERSTANDING THEIR DIVERSITY, STRUCTURE, PHYSIOLOGICAL ROLES AND INVOLVEMENT IN A NUMBER OF DISEASES. TODAY, MORE THAN 7,000 RESEARCH ARTICLES FOCUS ON THE CALPAINS. BECAUSE OF THE INCREASING RELEVANCE OF CALPAINS TO DISEASES SUCH AS EYE DISEASES, NEURODEGENERATION, MUSCLE AND METABOLIC DISEASES, WOUND HEALING, GASTROINTESTINAL DISEASE, INFLAMMATION, AND CANCER, THE FIELD IS CONTINUOUSLY EXPANDING. BETWEEN THE NIH, THE DOD AND NSF, THE FEDERAL GOVERNMENT INVESTS MORE THAN $33 MILLIONS PER YEAR IN THIS RESEARCH AREA, FUNDING MORE THAN 90 PROJECTS INVOLVING CALPAIN PROTEASES. THE MEETING IS BEING CO-ORGANIZED BY: VINIT MAHAJAN, STANFORD UNIVERSITY, MICHEL BAUDRY, WESTERN UNIVERSITY OF HEALTH SCIENCES, POMONA, CA, LEAH KOTTYAN, CINCINNATI CHILDREN’S HOSPITAL MEDICAL CENTER AND FREDERIC BROCARD, UNIVERSITE AIX-MARSEILLE, FRANCE. THE MEETING ADVISORY COMMITTEE INCLUDES: PETER DAVIES, QUEENS UNIVERSITY, ATHAR CHISHTI, TUFTS UNIVERSITY, DOROTHY CROALL, UNIVERSITY OF MAINE, JIM GEDDES, UNIVERSITY OF KENTUCKY, PETER GREER, QUEENS UNIVERSITY, CANADA, AND KEVIN WANG, UNIVERSITY OF FLORIDA. THIS FASEB-ORGANIZED MEETING IS THE PRIMARY OPPORTUNITY FOR CALPAIN RESEARCHERS AROUND THE WORLD TO GATHER AND EXCHANGE UNPUBLISHED DATA AND TO SYNERGIZE RESEARCH PROJECTS AND IDEAS. THUS, THIS MEETING LEVERAGES NIH’S INVESTMENT AND CATALYZES PROGRESS IN THE FIELD. THIS YEAR CONFERENCE HAS A STRONG COMPONENT ON CALPAINS AND EYE DISORDERS, AS RECENT FINDINGS HAVE REVEALED THE ROLES OF VARIOUS CALPAIN MUTATIONS IN SEVERAL EYE DISORDERS.

CONFERENCE: 2012 FASEB SUMMER RESEARCH CONFERENCE ON VIRUS STRUCTURE AND ASSEMBLY TO BE HELD AT THE VERMONT ACADEMY, SAXTONS RIVER, VERMONT

GENETIC RECOMBINATION AND GENOME REARRANGEMENTS - SUMMARY/ABSTRACT THIS APPLICATION SEEKS PARTIAL SUPPORT FOR THE FEDERATION OF AMERICAN SOCIETIES OF EXPERIMENTAL BIOLOGY (FASEB) SUMMER RESEARCH CONFERENCE (SRC) ON GENETIC RECOMBINATION AND GENOME REARRANGEMENTS, TO BE HELD JULY 12-17, 2026 IN SCOTTSDALE, ARIZONA. THIS WILL BE THE 21ST IN A SERIES OF HIGHLY SUCCESSFUL BIENNIAL CONFERENCES DEVOTED TO THESE TOPICS. THIS CONFERENCE BRINGS TOGETHER INVESTIGATORS STUDYING BROAD ASPECTS OF GENETIC RECOMBINATION AND GENOME REARRANGEMENTS IN A RANGE OF BIOLOGICAL SYSTEMS AND USING DIFFERENT EXPERIMENTAL APPROACHES. PRESENTATIONS WILL DESCRIBE CUTTING-EDGE, UNPUBLISHED WORK ON TIMELY QUESTIONS IN THE FIELD AND WILL FOSTER DISCUSSIONS AMONG PARTICIPANTS AT ALL CAREER STAGES. THIS CONFERENCE WILL PROVIDE UNIQUE OPPORTUNITIES FOR THE OPEN EXCHANGE OF DATA AND TECHNOLOGICAL INNOVATIONS THAT CAN BE ASSIMILATED AND EXPLOITED ACROSS THE ENTIRE FIELD. GENETIC RECOMBINATION COVERS MANY AREAS DIRECTLY RELEVANT FOR UNDERSTANDING THE BIOLOGY OF CANCER, NORMAL AGING, CELLULAR SENESCENCE, TELOMERE MAINTENANCE, AND THE ETIOLOGY OF AGING- RELATED DISEASES. HOMOLOGOUS RECOMBINATION IS ESSENTIAL FOR MAINTAINING GENOME STABILITY AND LIMITING GENOME REARRANGEMENTS THAT CAN PROMOTE DISEASE, AND MANY RECOMBINATION PROTEINS ACT AS SUPPRESSORS OF CANCER AND PREMATURE AGING. CONVERSELY, RECOMBINATION MEDIATES PROCESSES PROMOTING DISEASE, INCLUDING COMPLEX GENOME REARRANGEMENTS LEADING TO CANCER AND NEUROLOGICAL DISORDERS, FREQUENT CROSSING-OVER ASSOCIATED WITH PREMATURE AGING, AND ALTERNATIVE LENGTHENING OF TELOMERES (ALT), WHICH ALLOWS CELLS LACKING TELOMERASE TO ESCAPE SENESCENCE. RECOMBINATION PATHWAYS REPAIR DOUBLE-STRAND DNA BREAKS AND INTER-STRAND CROSSLINKS RESULTING FROM EXPOSURE TO ENVIRONMENTAL STRESSORS SUCH AS GAMMA-RAYS, IONIZING IRRADIATION, ALKYLATING AGENTS, AND UV LIGHT. THE FASEB CONFERENCE BRINGS TOGETHER INVESTIGATORS INTERESTED IN GENETIC RECOMBINATION FROM MANY DISTINCT DISCIPLINES, INCLUDING BIOCHEMISTRY, BIOPHYSICS, GENETICS, GENOMICS, AND CELL BIOLOGY. KEY TOPICS TO BE COVERED IN 2026 INCLUDE: (I) THE MOLECULAR MECHANISMS OF RECOMBINATION, (II) MEIOTIC RECOMBINATION, (III) TELOMERE DYNAMICS, AND THE ROLE OF ALT IN ESCAPING SENESCENCE; (IV) COMPLEX GENOME REARRANGEMENTS AND THEIR ROLE IN CANCER AND OTHER DISEASES, (V) REPAIR OF REPLICATION-ASSOCIATED DNA LESIONS, AND (VI) THE INFLUENCE OF CHROMATIN STRUCTURE ON RECOMBINATION. SPECIAL EMPHASIS ON THESE TOPICS IS REFLECTED IN OUR INITIAL SPEAKER INVITATIONS. IN ADDITION, ABOUT ONE-THIRD OF PLENARY SESSION TALKS WILL BE SELECTED BASED ON LATE-BREAKING ADVANCES AND FROM ABSTRACTS. A NUMBER OF INNOVATIONS TO THE CONFERENCE PLAN AND PROGRAM WILL FURTHER ENHANCE PARTICIPATION, INTERACTION, EXCHANGE AND DISCUSSION AMONG ALL PARTICIPANTS; AND INCREASE THE ABILITY OF YOUNGER SCIENTISTS TO HAVE SUSTAINED DISCUSSIONS WITH AND MENTORSHIP FROM MORE SENIOR CONFERENCE ATTENDEES. IN SUM, THE FASEB SRC ON GENETIC RECOMBINATION AND GENOME REARRANGEMENTS REMAINS THE MOST LONG- LASTING AND MOST IMPORTANT CONFERENCE ON THIS TOPIC OF DIRECT RELEVANCE TO HUMAN DISEASE.

ION CHANNEL REGULATION - THE FASEB SCIENCE RESEARCH CONFERENCE ON ION CHANNEL REGULATION, SCHEDULED FOR AUGUST 3-7, 2025, AT THE WELLSWORTH HOTEL IN SOUTHBRIDGE, MA, IS A BIENNIAL EVENT THAT HAS BEEN HELD SINCE 2003. THIS CONFERENCE WILL BE BE THE MOST SIGNIFICANT ION CHANNEL MEETING OF 2025, BRINGING TOGETHER GLOBAL EXPERTS TO PRESENT CUTTING-EDGE RESEARCH AND ENGAGE IN INTERDISCIPLINARY DISCUSSIONS. ION CHANNELS, CRUCIAL MEMBRANE PROTEINS REPRESENTING 1- 2% OF HUMAN GENES, ARE ESSENTIAL FOR VARIOUS CELLULAR PROCESSES AND ARE IMPLICATED IN NUMEROUS DISEASES, MAKING THEM IMPORTANT TARGETS FOR CURRENT AND FUTURE THERAPEUTICS. THE CONFERENCE, CO-CHAIRED BY DRS. ROSE DIXON AND JONATHAN SILVA, WILL FEATURE A KEYNOTE LECTURE BY DR. JEANNE NERBONNE, TEN SCIENTIFIC SESSIONS WITH 30 INVITED SPEAKERS, POSTER SESSIONS, AND 23 SHORT TALKS DEDICATED TO TRAINEES AND EARLY-CAREER RESEARCHERS. THE CONFERENCE HAS THREE MAIN AIMS: TO DISSEMINATE THE LATEST DISCOVERIES AND FACILITATE CROSS-POLLINATION OF IDEAS ACROSS SUBFIELDS, TO DEVELOP MULTIDISCIPLINARY NETWORKS INTEGRATING VARIOUS APPROACHES, AND TO SUPPORT AND TRAIN THE NEXT GENERATION OF ION CHANNEL RESEARCHERS. THE INTIMATE SETTING WITH 100-175 PARTICIPANTS PARTICIPATING IN SCIENTIFIC DISCOURSE IN A VENUE WHERE THEY WILL ALSO ENJOY MEALS AND SOCIAL GATHERINGS ALLOWS FOR MORE ORGANIC AND LESS DAUNTING EXCHANGES AMONG ATTENDEES AT ALL CAREER STAGES. SPECIAL FEATURES INCLUDE FLASH TALKS, A TRAINEE-FIRST QUESTION FORMAT, AND BREAKOUT SESSIONS FOR EARLY-CAREER PROFESSIONALS. THE CONFERENCE WILL FEATURE ACCOMPLISHED INVITED SPEAKERS AND DISCUSSION LEADERS SELECTED FOR THEIR SCIENTIFIC EXPERTISE AND CONTRIBUTIONS TO THE FIELD, AS WELL AS THE MOST PROMISING EARLY-CAREER RESEARCHERS SHOWCASING INNOVATIVE WORK. BY ACHIEVING THESE AIMS, THE 2025 FASEB SRC ON ION CHANNEL REGULATION WILL SIGNIFICANTLY CONTRIBUTE TO ADVANCING THE FIELD, NURTURING EMERGING TALENT, AND FOSTERING COLLABORATION IN THE FIELD OF ION CHANNEL RESEARCH.

FASEB SRC ON ION CHANNEL REGULATION

FASEB SRC ON ION CHANNEL REGULATION

FASEB SRC ON MOBILE DNA IN MAMMALIAN GENOMES

FASEB SRC: THE 6TH INTERNATIONAL CONFERENCE ON RETINOIDS - PROJECT SUMMARY / ABSTRACT THIS NIH R13 APPLICATION REQUESTS REQUESTING PARTIAL FUNDING FOR THE 2022 FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB) “6TH INTERNATIONAL CONFERENCE ON RETINOIDS” THAT WILL BE HELD AT OHIO UNIVERSITY, ATHENS, OH FROM JUNE 5, 2022 TO JUNE 10, 2022. THE FASEB SCIENCE RESEARCH CONFERENCE ON RETINOIDS HAS BEEN HELD EVERY OTHER YEAR SINCE 1982 WHERE THE MEETING PLANNED FOR 2022 WILL BE THE 21ST FASEB SCIENCE RESEARCH CONFERENCE ON RETINOIDS. THIS BIENNIAL RESEARCH CONFERENCE HAS BEEN VERY WELL ATTENDED (RANGING FROM 100 TO 200 ATTENDEES OVER THE PAST 40 YEARS) AND REMAINS THE ONLY MAJOR NATIONAL AND INTERNATIONAL CONFERENCE COMMITTED TO FOCUS ON THE STUDIES OF RETINOIDS, AND TO COMPREHENSIVELY ADDRESS THE BROAD SPECTRUM OF RETINOID ACTIONS AND APPLICATION IN AN INTEGRATIVE MANNER. WHILE THE MECHANISMS OF ACTION AND THE BIOLOGICAL FUNCTIONS OF RETINOIDS HAVE BEEN INTENSIVELY STUDIED, THERE IS AN INCREASING NEED FOR UNDERSTANDING AND APPLYING RETINOIDS IN HUMAN NUTRITION AND DISEASES. CURRENTLY, A GREAT DEAL OF RESEARCH ACTIVITY IS SUPPORTED BY THE NIH (THE NIH REPORTER DATABASE INDICATES 2190 NIH FUNDED INDIVIDUAL RESEARCH GRANTS INVOLVING ASPECTS OF RETINOID/VITAMIN A BIOLOGY). THE MAIN TOPICS TO BE ADDRESSED INCLUDE BOTH BASIC AND TRANSLATIONAL FRONTS OF RETINOID BIOLOGY: 3 SESSIONS ON RETINOID MECHANISMS (I, RETINOID RECEPTORS, RETINOID RECEPTOR-MEDIATED BIOLOGY; II, RETINOID METABOLISM, HOMEOSTASIS, AND ENZYMOLOGY; III, DEVELOPMENT, STEM CELL AND REGENERATIVE BIOLOGY); 3 SESSIONS ON RETINOIDS AND DISEASE (I, IMMUNE DISORDERS AND IMMUNOLOGY; II, SIGNALING AND METABOLIC DYSFUNCTION; III, CANCER AND RELATED PATHOLOGIES), AND 2 SESSIONS ON MOLECULAR THERAPEUTICS (I, RETINOID MECHANISMS AND NOVEL TARGETS; II, REXINOIDS AND NOVEL PHARMACOLOGICAL APPLICATIONS). THE OVERALL GOAL IS TO BRING TOGETHER A GROUP OF COMMITTED INVESTIGATORS (SENIOR SCIENTISTS, MID-CAREER SCIENTISTS, JUNIOR SCIENTISTS, POSTDOCTORAL FELLOWS, AND GRADUATE STUDENTS), WHO WORK IN DIVERSE DISCIPLINES (AS BIOCHEMISTS, MOLECULAR BIOLOGISTS, NUTRITIONAL SCIENTISTS, CANCER RESEARCHERS, VISION RESEARCHERS, STEM CELL BIOLOGISTS, BIOPHYSICISTS, STRUCTURAL BIOLOGISTS, IMMUNOLOGISTS, CHEMISTS, AND CLINICIANS) TO PRESENT AND DISCUSS THEIR LATEST RESEARCH FINDINGS THAT SHARE A COMMON FOCUS ON THE RETINOIDS. TO ENCOURAGE NEW/YOUNG INVESTIGATORS AND TRAINEES TO ATTEND THIS MEETING, WE PLAN TO OFFER SIX CAREER- ORIENTED TRAINING SESSIONS AND SIX MEET-THE-EXPERT SESSIONS. TO INCREASE VISIBILITY OF EARLY-STAGE INVESTIGATORS AND TRAINEES THROUGH ORAL PRESENTATIONS, WE PLAN EIGHT SPEAKING OPPORTUNITIES AND TWENTY-NINE SHORT TALK AND CAPSULE REPORTS PRESENTATIONS TO BE CHOSEN FROM THE SUBMITTED ABSTRACTS. THIS MEETING HAS BEEN STRONGLY SUPPORTED BY NIH IN THE PAST. WE RESPECTFULLY REQUEST PARTIAL SUPPORT FOR THE 2022 FASEB RETINOID CONFERENCE TO INCREASE THE ATTENDANCE BY UNDER-REPRESENTED AND WOMEN SCIENTISTS, TRAINEES, POSTDOCTORAL FELLOWS, AND EARLY- STAGE INVESTIGATORS TO FACILITATE ENTRY INTO THIS RESEARCH AREA IN ORDER TO SPUR INTERDISCIPLINARY AND TRANSLATIONAL SCIENCE AS WELL AS COLLABORATIONS BETWEEN BASIC SCIENTISTS AND CLINICIANS.

FASEB SRC ON MITOCHONDRIAL BIOGENESIS AND DYNAMICS IN HEALTH, DISEASE AND AGING

TAS::89 0222::TAS; NEW; FASEB SUMMER CONFERENCES: MECHANISMS IN PLANT DEVELOPMENT AUGUST 15-19 2010; PI: SARAH HAKE

FASEB SCIENCE RESEARCH CONFERENCE ON MECHANISMS IN PLANT DEVELOPMENT

FASEB SCIENCE RESEARCH CONFERENCE ON MECHANISMS OF PLANT DEVELOPMENT

FASEB SRC ON MECHANISMS IN PLANT DEVELOPMENT

CONFERENCE: FASEB MEETING SUPPORT - MECHANISMS OF PLANT DEVELOPMENT AUGUST 15-19 2010 SAXONS RIVER VERMONT

2008 FASEB MEETING FOR RETINAL NEUROBIOLOGY AND VISUAL PROCESSING; JULY 20-25, 2008 IN SNOWMASS COLORADO

TGF-Β SUPERFAMILY CONFERENCE: SIGNALING IN DEVELOPMENT AND DISEASE - ABSTRACT THE FASEB SRC TGF-Β SUPERFAMILY: SIGNALING IN DEVELOPMENT AND DISEASE CONFERENCE IN 2024 (HEREAFTER “TGF-Β 2024”) WILL BRING TOGETHER INVESTIGATORS WHO ARE LEADERS IN A VARIETY OF INTERCONNECTED AND INTERRELATED DISCIPLINES THAT INTERSECT THROUGH A KEY ROLE OF TGF-Β SIGNALING IN THE PROCESS. BRINGING TOGETHER SUCH A DIVERSE GROUP OF SCIENTISTS IS ESSENTIAL FOR A COMPREHENSIVE UNDERSTANDING AND ASSESSMENT OF THE TGF-Β SIGNALING AXIS IN DEVELOPMENT, HOMEOSTASIS, REGENERATION, AGING, INJURY, AND DISEASE. THE SCIENTIFIC PRESENTATIONS, FORMAL AND INFORMAL DISCUSSIONS, AND POSTER PRESENTATIONS THROUGHOUT THE CONFERENCE ARE DESIGNED TO EXPAND THE UNDERSTANDING OF THE GENETIC, MOLECULAR AND CELLULAR MECHANISMS AND PROCESSES BY WHICH THE TGF-Β SIGNALING AXIS INFLUENCES DEVELOPMENT AND MAINTENANCE OF ORGAN SYSTEMS, AND TO UNCOVER HOW DEREGULATION OF THIS CONTROL RESULTS IN DISEASE. THIS KNOWLEDGE IS FUNDAMENTAL TO UNDERSTAND HOW TGF-Β SIGNALING PATHWAYS ARE REGULATED AND HOW THEY EXECUTE THEIR FUNCTIONS UNDER NORMAL CONDITIONS IN RESTORING THE HOMEOSTASIS OF THE BODY AND FACILITATING SUCCESSFUL TISSUE REPAIR AND REGENERATION. TGF-Β 2021 WILL LEVERAGE NEW AND IMPORTANT FINDINGS AND PROVIDE ATTENDEES WITH: A BROADER APPRECIATION AND PERSPECTIVE OF THE COMPLEXITY OF THE TGF-Β SIGNALING AXIS; EXAMPLES OF THERAPEUTIC STRATEGIES BEING TESTED AND OPPORTUNITIES FOR CONSIDERING AND DISCUSSING FUTURE ONES. THIS IS THE 13TH FASEB TGF-Β CONFERENCE. THE FIELD OF TGF-Β SIGNALING HAS BEEN RAPIDLY ADVANCING AND EXPANDING; IN PARTICULAR, ALMOST 10,000 ARTICLES PER YEAR RELATED TO TGF-Β/BMP/GDF/ACTIVIN/NODAL HAVE BEEN PUBLISHED IN THE PAST FIVE YEARS. THIS FAST PACE WARRANTS THE CONVENING OF THIS CONFERENCE AND ENSURES ITS SUCCESS. TGF-Β 2024 TAKES PRIDE IN THE STRONG TRADITION OF COLLEGIALITY OF CONFERENCE ATTENDEES AND, MOST IMPORTANTLY, THE COLLABORATIONS THAT ARE GENERATED THROUGH THIS CONFERENCE. THE COLLECTIVE EXPERIENCE BUILT OVER THE PREVIOUS TWELVE CONFERENCES HAS PROVIDED US WITH THE CONFIDENCE THAT TGF-Β 2024 PROVIDES A FORUM FOR EXTENDED DISCUSSIONS AND CONVERSATIONS, INTERACTIONS, NETWORKING, DEBATING OF NOVEL HYPOTHESES AND PRIORITIZATION OF UNMET RESEARCH OR THERAPEUTIC NEEDS, AND CAREER TRAINING/ADVICE PARTICULARLY FOR YOUNG INVESTIGATORS AND TRAINEES FROM DIVERSE BACKGROUNDS WHO REPRESENT FUTURE RESEARCHERS IN THIS FIELD.

CONFERENCE - MECHANISMS IN PLANT DEVELOPMENT, IN SAXTONS RIVER, VERMONT, USA.

MEETING: FASEB CONFERENCE ON MECHANISMS IN PLANT DEVELOPMENT, JULY 30 - AUGUST 4, 2017 SAXTONS RIVER, VERMONT, USA

FASEB CONFERENCE-HEMATOLOGICAL MALIGNANCIES

MEETING: FASEB CONFERENCE ON MECHANISMS IN PLANT DEVELOPMENT MEETING TO BE HELD ON JULY 28 - AUGUST 2, 2019 AT ST. BONAVENTURA UNIVERSITY, OLEAN (NY)

FASEB SRC ON MATRICELLULAR PROTEINS IN INFLAMMATION AND TISSUE REMODELING

TRANSCRIPTIONAL REGULATION DURING CELL GROWTH; DIFFERENTIATION AND DEVELOPMENT

FASEB SUMMER CONFERENCES: MECHANISMS IN PLANT DEVELOPMENT

HIPPO PATHWAY IN BIOLOGY AND DISEASES - PROJECT SUMMARY THE OVERALL GOAL OF THIS PROPOSAL IS TO OBTAIN FUNDING SUPPORT FOR EARLY-CAREER RESEARCHERS (I.E., PHD STUDENTS, POSTDOCTORAL FELLOWS) AND JUNIOR FACULTY TO ATTEND THE “2024 FASEB SCIENTIFIC RESEARCH CONFERENCE: HIPPO PATHWAY IN BIOLOGY AND DISEASES” HELD AT THE CROWNE PLAZA MELBOURNE-OCEANFRONT, MELBOURNE, FLORIDA BETWEEN NOVEMBER 10-14, 2024. THE HIPPO PATHWAY FUNCTIONS IN NUMEROUS PHYSIOLOGICAL PROCESSES AND IS FREQUENTLY DYSREGULATED IN HUMAN DISEASES INCLUDING CANCER. WE WILL CONVENE AN OUTSTANDING AND DIVERSE GROUP OF SCIENTISTS WORKING AT THE FOREFRONT OF THE HIPPO FIELD TO GAIN NEW INSIGHTS INTO THE HIPPO PATHWAY IN BROAD BIOLOGICAL EVENTS, ITS ALTERATION IN CONTRIBUTING TO CANCER AND OTHER HUMAN DISEASES, AND NEW CONCEPTS ON DRUG DEVELOPMENT TARGETING THE HIPPO PATHWAY. TO ACHIEVE THESE GOALS, THE CONFERENCE WILL FOCUS ON MULTIPLE TOPICS RELATED TO THE HIPPO PATHWAY RESEARCH, WHICH INCLUDE BUT ARE NOT LIMITED TO THE MECHANISM OF HIPPO SIGNALING, HIPPO PATHWAY IN STEM CELLS AND DEVELOPMENT, HIPPO PATHWAY IN CANCER, HIPPO PATHWAY IN IMMUNOLOGY AND CANCER IMMUNITY, HIPPO-BASED DRUG DEVELOPMENT. TWO CAREER DEVELOPMENT WORKSHOPS AND ONE MEET THE EXPERTS SESSION ARE PLANNED FOR EARLY-CAREER RESEARCHERS AND JUNIOR FACULTY DURING THE CONFERENCE. THROUGH THESE EXCITING PROGRAMS, WE AIM TO 1) IDENTIFY KNOWLEDGE GAPS AND OPPORTUNITIES FOR SCIENTISTS, CLINICIANS, NONPROFITS, AND INDUSTRY PARTNERS TO SHARE AND DISCUSS CUTTING-EDGE RESEARCH ON HIPPO PATHWAY REGULATION, FUNCTION, AND THERAPY; 2) TRAIN THE NEXT GENERATION OF SCIENTIFIC LEADERS BY PROVIDING NETWORKING AND PROFESSIONAL DEVELOPMENTAL OPPORTUNITIES FOR EARLY- CAREER RESEARCHERS AND JUNIOR FACULTY; 3) PROMOTE THE PARTICIPATION AND PUBLIC PRESENTATIONS OF WOMEN AND UNDERREPRESENTED MINORITIES BY PROVIDING WITH OPPORTUNITIES OF PLENARY TALKS, TRAVELING AWARDS, AND POSTER/WORKSHOP DISCUSSIONS; AND 4) DISSEMINATE THE LATEST HIPPO SIGNALING DISCOVERIES BY PUBLISHING THE PROCEEDINGS OF THE CONFERENCE, BOOSTING NEW COLLABORATIONS, AND WRITING CO-AUTHORED REVIEWS. WE ARE COMMITTED TO BRINGING DIVERSE SCIENTISTS TOGETHER TO DISCUSS SCIENTIFIC ADVANCES AND SHARE CUTTING-EDGE RESEARCH IN A SAFE AND INCLUSIVE ENVIRONMENT. THIS VERY FIRST FASEB HIPPO CONFERENCE WILL HAVE A MAJOR IMPACT ON THE FIELD BY ACCELERATING TEAM SCIENCE AND PROVIDING A UNIQUE OPPORTUNITY FOR CROSS-FERTILIZATION OF NEW IDEAS AND TRAINING THE NEXT GENERATION OF SCIENTIFIC LEADERS IN CANCER RESEARCH.

DYNAMICS AND ENCODING IN CELL SIGNALING - PROJECT SUMMARY CELL COMMUNICATION RESEARCH IS A GROWING FIELD THAT IS COMPLIMENTARY TO, BUT DISTINCT FROM, TRADITIONAL SIGNAL TRANS- DUCTION FIELDS. THIS EMERGING FIELD EMPHASIZES THE SPATIOTEMPORAL ASPECTS OF CELL COMMUNICATION AND QUANTITATIVE UNDERSTANDING OF HOW INFORMATION TRANSMISSION AND PROCESSING OCCURS. A CENTRAL FOCUS ON THE FIELD IS TO UNDER- STAND EXACTLY WHAT DISTINGUISHES “NORMAL” AND “DISEASE” CELL SIGNALING BEHAVIOR IN TERMS OF SPATIAL AND TEMPORAL DETAILS. THERE ARE AT LEAST 80 LABS WORLDWIDE THAT USE LIVE CELL IMAGING, GENETICALLY ENCODED BIOSENSORS, COMPU- TATIONAL IMAGE ANALYSIS, AND MATHEMATICAL MODELS TO DETERMINE MODERN QUANTITATIVE CONCEPTS FOR CELL COMMUNI- CATION. IN 2024 WE HELD THE INAUGURAL SIGNALING DYNAMICS AND ENCODING CONFERENCE. THE CONFERENCE WAS CRE- ATED TO PROVIDE SCIENTISTS IN THE FIELD WITH THE OPPORTUNITY FOR CROSS-FERTILIZATION OF SHARED HIGHER-LEVEL CONCEPTS ACROSS THE MANY PATHWAYS STUDIED IN THE FIELD, INCLUDING IMMUNE SIGNALING, RECEPTOR-MEDIATED SIGNAL TRANSDUC- TION, GENE EXPRESSION, CELL CYCLE, AND METABOLIC SIGNALING PATHWAYS. THE CONFERENCE WAS A SUCCESS, ATTRACTING 136 SCIENTISTS FROM AROUND THE WORLD, INCLUDING OVER 60 PIS AND 57 TRAINEES. TO CONTINUE THE SUCCESS OF THIS CONFERENCE, WE ARE PLANNING A 2ND SIGNALING DYNAMICS AND ENCODING FASEB SCIENTIFIC RESEARCH CONFERENCE ON JUNE 21-25, IN NASHVILLE TENNESSEE. WE WILL BRING TOGETHER AN INTERNATIONAL COMMUNITY IN THE CELL COMMUNICATION FIELD. TO ACCOMPLISH THIS, WE AIM TO (1) PROVIDE STRUCTURE FOR AN EMERGING RESEARCH FIELD BY ESTABLISHING AND BUILDING RELATIONSHIPS AND COLLABORATIONS BETWEEN SENIOR SCIENTISTS AND EARLY CAREER RESEARCHERS THROUGH NET- WORKING OPPORTUNITIES AND A SPEAKER LINEUP INCLUDING BOTH EARLY CAREER RESEARCHERS AND ESTABLISHED LEADERS. THIS INCLUDES 20 TRAINEE TALKS OVER THE COURSE OF THE CONFERENCE. LIGHTENING TALKS WILL HIGHLIGHT TRAINEE POSTERS AND ENCOURAGE INTERACTIONS AND NETWORKING AT POSTER SESSIONS BETWEEN TRAINEES AND ESTABLISHED INVESTIGATORS. WE AIM TO (2) PROVIDE TRAINEES WITH KNOWLEDGE, NETWORKS, AND MENTORS FOR CAREER OPPORTUNITIES THROUGH MEETINGS AND NETWORKING OPPORTUNITIES WITH ESTABLISHED RESEARCHERS IN BOTH INDUSTRY AND ACADEMIA. THIS FIRST ITERATION OF THE MEETING WILL AIM TO (3) CREATE NEW MODELS BY CONNECTING RESEARCHERS INTERESTED IN RELATED CONCEPTS ACROSS BIOLOGICALLY DIFFERENT SIGNALING AND REGULATORY SYSTEMS, PROVIDING OPPORTUNITIES FOR RESEARCHERS TO THINK OUTSIDE THE TYPICAL BOUNDARIES OF THEIR WORK AND FIND NEW INSIGHTS FROM COLLEAGUES IN PARALLEL FIELDS. WE WILL ALSO AIM TO (4) PROMOTE ACCESS TO NEW IMAGE ANALYSIS AND MODELING TECHNOLOGIES BY EMPHASIZING THE LATEST TECHNICAL AD- VANCES IN THESE AREAS. ALTOGETHER, THE DYNAMICS AND ENCODING IN CELL SIGNALING FASEB SCIENTIFIC RESEARCH CONFERENCE PROVIDES A MUCH NEEDED AND EXCITING FORUM FOR THE CELL COMMUNICATION FIELD AND WILL ENABLE CROSS- DISCIPLINARY COLLABORATIONS AND INSIGHTS INTO CELL FUNCTION AND BEHAVIOR THAT IS NOT CURRENTLY POSSIBLE.

FASEB SRC ON FROM CAUSES TO CONSEQUENCES, TO TREATMENT: OBESITY IN PERSPECTIVE

THE PHYSIOLOGICAL BASIS FOR OBESITY THERAPEUTICS

FASEB SRC ON SKELETAL MUSCLE SATELLITE CELLS AND REGENERATION

FASEB SCIENCE RESEARCH CONFERENCE ON SKELETAL MUSCLE SATELLITE AND STEM CELLS

GASTROINTESTINAL TRACT XXI - PROJECT SUMMARY/ABSTRACT THIS APPLICATION REQUESTS PARTIAL SUPPORT FOR A FASEB SCIENTIFIC RESEARCH CONFERENCE ENTITLED “GASTROINTESTINAL TRACT XXI: "LIFE, DEATH AND DISEASE OF THE GUT” THAT IS SCHEDULED FOR SEPTEMBER 8-12, 2024 IN BANFF, ALBERTA, CANADA. THE MEETING WILL CONVENE A DIVERSE GROUP OF SPEAKERS, INCLUDING MANY WOMEN, UNDERREPRESENTED GROUPS, AND YOUNG INVESTIGATORS, TO DISCUSS THE BIOLOGY OF THE GASTROINTESTINAL TRACT AND ITS DYSREGULATION IN THE SETTING OF DISEASE. A KEYNOTE ADDRESS PLUS EIGHT LECTURE SESSIONS WILL ADDRESS GASTROINTESTINAL STEM CELL HOMEOSTASIS AND PLASTICITY IN RESPONSE TO INJURY/DISEASE, NUTRITION AND METABOLISM, NOVEL APPROACHES USING GI ORGANOIDS, THE MICROBIOTA-GUT-BRAIN AXIS, EPITHELIAL PHYSIOLOGY, MICROBIAL HOMEOSTASIS, MUCOSAL INFLAMMATION, IBD, AND CANCER. AMPLE TIME WILL BE SET ASIDE FOR DISCUSSIONS AMONGST PARTICIPANTS, AND THE PRESENTATION OF UNPUBLISHED DATA WILL BE PRIORITIZED. THERE WILL ALSO BE TWO POSTER SESSIONS AS WELL AS SEVERAL CAREER DEVELOPMENT ACTIVITIES FOR EARLY CAREER INVESTIGATORS AND TRAINEES, AND OPPORTUNITIES TO PROMOTE THE VISIBILITY OF THESE INDIVIDUALS WHO REPRESENT THE FUTURE OF THE FIELD. WE HAVE ASSEMBLED AN INNOVATIVE PROGRAM WITH COMMITTED PARTICIPATION FROM LEADERS WITH DIVERSE EXPERTISE WITHIN GI-RELATED RESEARCH FIELDS. OVERALL, IN AN INTIMATE AND SECLUDED SETTING THAT ENCOURAGES INFORMAL INTERACTIONS BETWEEN SCIENTISTS AT ALL LEVELS, WE PROVIDE AN INNOVATIVE APPROACH TO THE EXCHANGE OF IDEAS AND SYNTHESIS OF SCIENCE THAT WILL MOVE THE FIELD OF GI RESEARCH FORWARD. THE CONFERENCE HAS A 39-YEAR TRACK RECORD OF SERVING AS A FOUNDATIONAL MEETING FOR TRAINEES AS EVIDENCED BY YEAR-AFTER-YEAR ATTENDANCE BY THOSE WHO HAVE MATRICULATED IN RESEARCH-RELATED CAREERS SPANNING FROM BASIC SCIENCE DISCOVERY TO CLINICAL SIGNIFICANCE FOR GI HEALTH AND DISEASE. IT IS THEREFORE EXPECTED THAT THE MEETING WILL PROVIDE NEW INSIGHTS NOT ONLY INTO BASIC GASTROINTESTINAL PHYSIOLOGY, NEUROBIOLOGY, DEVELOPMENTAL BIOLOGY, AND MICROBIOLOGY, BUT ALSO HOW TO TREAT, AND ULTIMATELY CURE, A WIDE VARIETY OF DIGESTIVE DISEASE STATES.

LIPID DROPLETS - PROJECT SUMMARY THE 9TH FASEB SUMMER RESEARCH CONFERENCE ON "LIPID DROPLETS" WILL DELVE INTO THE RAPIDLY EVOLVING FIELD OF LIPID DROPLET BIOLOGY. AS THE PRIMARY CELLULAR LIPID STORAGE ORGANELLES, LIPID DROPLETS SERVE AS VITAL HUBS OF LIPID METABOLISM, INFLUENCING ENERGY METABOLISM, LIPID SIGNALING, MEMBRANE BIOGENESIS, AND LIPOTOXICITY. THE ACCUMULATION OF LIPID DROPLETS IS A PATHOLOGICAL HALLMARK OF METABOLIC DISEASES, INCLUDING OBESITY, INSULIN RESISTANCE, DIABETES, NONALCOHOLIC FATTY LIVER DISEASE, LIPODYSTROPHY, AND CARDIOVASCULAR DISEASE. NEW ROLES FOR LIPID DROPLETS HAVE EMERGED IN THE ETIOLOGY OF NEURODEGENERATION, CANCER, AND THE HOST RESPONSE TO PATHOGENS. THE ESCALATING GLOBAL PREVALENCE OF LIPID DISORDERS UNDERSCORES THE URGENCY TO UNDERSTAND THE MOLECULAR UNDERPINNINGS OF LIPID DROPLET BIOLOGY AS WELL AS THEIR PROFOUND IMPACT ON DISEASE PATHOGENESIS. A COMPREHENSIVE UNDERSTANDING OF LIPID DROPLETS IS ESSENTIAL FOR THERAPEUTIC DEVELOPMENT AND IS OF HIGH INTEREST TO SCIENTISTS IN ACADEMIC AND BIOTECHNOLOGY SECTORS. THIS CONFERENCE WILL TAKE PLACE FROM JULY 21-25 2024, IN SAINT PAUL, MN AND WILL INCLUDE TWO KEYNOTE ADDRESSES FROM LEADERS IN THE FIELDS OF LIPID METABOLISM AND ORGANELLE BIOLOGY: JENNIFER LIPPINCOTT-SCHWARTZ (HHMI JANELIA FARM) AND GÖKHAN HOTAMIŞLIGIL (HARVARD). AS ONE OF THE LIPID METABOLISM COMMUNITY’S PREMIERE SCIENTIFIC CONFERENCES, AND THE LONGEST-RUNNING MEETING SOLELY FOCUSED ON LIPID DROPLET BIOLOGY, IT WILL FEATURE A MULTI-DISCIPLINARY SPEAKER LINE-UP FOCUSED ON LEADING- EDGE RESEARCH. THE CONFERENCE FORMAT COMPRISES 8 SESSIONS WITH TALKS BY 24 INVITED SPEAKERS, 14 SHORT TALKS SELECTED FROM SUBMITTED ABSTRACTS, TWO POSTER SESSIONS, A CAREER-ORIENTED WORKSHOP, AND SEVERAL MEET THE EXPERTS SESSIONS. THIS HIGHLY INCLUSIVE ENVIRONMENT IS CRAFTED TO FOSTER INTERACTIONS BETWEEN TRAINEES, EARLY CAREER INVESTIGATORS, AND ESTABLISHED RESEARCHERS. DURING THE SCIENTIFIC SESSIONS, DISTINGUISHED RESEARCHERS WILL DELIVER TALKS SPANNING THE ENTIRE SPECTRUM OF LIPID DROPLET BIOLOGY FROM BASIC TO CLINICAL RESEARCH, PRESENTING DIVERSE APPROACHES (BIOPHYSICS, GENETICS, BIOCHEMISTRY, CELL BIOLOGY, PHYSIOLOGY) AND CUTTING-EDGE TECHNOLOGIES (CHEMICAL BIOLOGY, LIPIDOMICS, IMAGING) IN A RANGE OF MODEL SYSTEMS (CULTURED CELLS, FLIES, YEAST, C. ELEGANS, MICE, HUMANS). A PRIMARY AIM OF THIS CONFERENCE IS TO EMPOWER THE NEXT GENERATION OF SCIENTISTS. TO THAT END, WE SEEK FUNDING TO SUPPORT THE PARTICIPATION OF GRADUATE STUDENTS, POSTDOCTORAL FELLOWS, AND EARLY CAREER INVESTIGATORS, WITH A SPECIAL EMPHASIS ON INCLUSIVITY, INCLUDING WOMEN, UNDERREPRESENTED MINORITIES, AND PERSONS WITH DISABILITIES. THE CONFERENCE'S SETTING WILL PROVIDE NUMEROUS OPPORTUNITIES FOR BOTH PLANNED AND SPONTANEOUS INFORMAL INTERACTIONS, AFFORDING YOUNG INVESTIGATORS THE CHANCE TO PRESENT THEIR WORK, OBTAIN VALUABLE FEEDBACK FROM LEADERS IN THE FIELD, AND RECEIVE CAREER GUIDANCE. THIS CONFERENCE STANDS AS THE PIONEERING INTERNATIONAL GATHERING DEDICATED EXCLUSIVELY TO LIPID DROPLET BIOLOGY AND ITS RELEVANCE TO HUMAN DISEASE. IT CONTINUES TO SERVE AS A UNIQUE PLATFORM FOR RESEARCHERS TO EXCHANGE IDEAS AND SHARE GROUNDBREAKING RESULTS IN THIS DYNAMIC AND TIMELY FIELD.

TRANSLATIONAL NEUROIMMUNOLOGY - PROJECT SUMMARY THE PURPOSE OF THIS R13 PROPOSAL IS TO SUPPORT THE ATTENDANCE OF TRAINEES, YOUNG INVESTIGATORS, AND INDIVIDUALS HISTORICALLY UNDERREPRESENTED IN SCIENCE AND MEDICINE, AT THE 2024 FASEB CONFERENCE: TRANSLATIONAL NEUROIMMUNOLOGY: FROM BENCH TO BEDSIDE AND BACK. THIS WILL BE THE 16TH BIANNUAL FASEB NEUROIMMUNOLOGY CONFERENCE, THE FIRST HAVING BEEN HELD IN 1988. THE CURRENT MEETING WILL BE HELD JULY 28-AUGUST 1, 2024 AT THE NIAGARA FALLS CONFERENCE CENTER. NEUROIMMUNOLOGY IS ONE OF THE FASTEST GROWING FIELDS IN BIOMEDICAL RESEARCH AND HAS BEEN HIGHLY SUCCESSFUL IN TERMS OF THE TRANSLATION OF WET BENCH DISCOVERIES INTO IMPACTFUL CLINICAL THERAPIES. THE OVERALL OBJECTIVE OF THIS CONFERENCE IS TO BRING TOGETHER DIVERSE LEADING EXPERTS AND TRAINEES ENGAGED IN NEUROIMMUNOLOGY RESEARCH FROM A BROAD RANGE OF PERSPECTIVES, IN A COLLEGIAL AND SUPPORTIVE ENVIRONMENT. THE SPECIFIC GOALS ARE TO: 1) PROVIDE A FORUM FOR THE PRESENTATION OF UNPUBLISHED, CUTTING-EDGE RESEARCH ON THE INTERSECTION OF THE IMMUNE AND NERVOUS SYSTEMS IN HUMAN HEALTH AND DISEASE, BY SPEAKERS FROM DIVERSE BACKGROUNDS; 2) PROVIDE OPPORTUNITIES FOR BOTH FORMAL AND INFORMAL DISCUSSIONS AMONGST WORLD EXPERTS TO PROMOTE NEW COLLABORATIONS AND NEW EFFORTS TO TRANSLATE SCIENTIFIC INSIGHTS FROM “BENCH TO BEDSIDE”; 3) SUPPORT THE PARTICIPATION OF YOUNG INVESTIGATORS, PARTICULARLY THOSE TRADITIONALLY UNDER-REPRESENTED IN THE FIELD, AND FACILITATE THEIR INTEGRATION INTO THE BROADER RESEARCH COMMUNITY IN A MEANINGFUL AND INTERACTIVE WAY; (4) PROMOTE CAREER DEVELOPMENT SKILLS AND PRINCIPLES OF JUSTICE, EQUITY, DIVERSITY AND INCLUSION IN THE DESIGN, CONDUCT AND EVALUATION OF RESEARCH AND THE DEVELOPMENT OF THE NEUROIMMUNOLOGY WORKFORCE. THE PROGRAM IS INTENTIONALLY MULTIFACETED IN A SINGLE-TRACK, WITHOUT COMPETING TALKS, TO ENSURE THAT ATTENDEES WORKING ON DIFFERENT ASPECTS OF NEUROIMMUNOLOGY RESEARCH HAVE THE OPPORTUNITY TO MEET COLLEAGUES WITH COMPLEMENTARY INTERESTS AND AREAS OF EXPERTISE TO INSPIRE NEW IDEAS AND COLLABORATIVE PROJECTS. THE AGENDA ALSO CONSISTS OF POSTER SESSIONS, WORKSHOPS AND “MEET THE EXPERT” SESSIONS AND UNSCHEDULED AFTERNOON TIME TO ENCOURAGE INFORMAL COMMUNICATIONS. THESE COLLECTIVE FEATURES OF THE CONFERENCE WILL FACILITATE BRAINSTORMING AND MENTORING IN A VARIETY OF FORMATS. A PRIORITY IS TO INSPIRE WOMEN SCIENTISTS, AND LEARNERS AND JUNIOR FACULTY FROM GROUPS THAT ARE TRADITIONALLY UNDERREPRESENTED IN SCIENCE AND MEDICINE, AND TO CONNECT THOSE INDIVIDUALS WITH ROLE MODELS, FUTURE MENTORS, AND PEERS, THEREBY STRENGTHENING THEIR COMMITMENT TO NEUROIMMUNOLOGY RESEARCH. TO THAT END, WE ARE SPONSORING WORKSHOPS ON “FOSTERING DIVERSITY AND EQUITY IN STUDY DESIGN AND THE NEUROIMMUNOLOGY WORKFORCE.” AND “SCIENTIFIC TRANSPARENCY AND RIGOR” AS WELL AS A CAREER PANEL DISCUSSION ON ““CAREER PATHWAYS FROM ACADEMIA TO INDUSTRY.” THIS CONFERENCE IS DESIGNED TO FOSTER NEW, CREATIVE PARTNERSHIPS AND MENTORSHIPS AMONG WET BENCH SCIENTISTS, CLINICAL TRIALISTS/ RESEARCHERS, AND CLINICIANS WHO ARE FOCUSED ON NEUROIMMUNOLOGY, ULTIMATELY LEADING TO CLINICAL ADVANCES AND THE LONG-TERM SUCCESS OF THE FIELD.

FASEB SRC ON TRACE ELEMENTS IN BIOLOGY AND MEDICINE

FASEB'S "THE STEROID HORMONES AND RECEPTORS IN HEALTH AND DISEASE CONFERENCE - JOINTLY HOSTED BY FASEB AND THE INTERNATIONAL COMMITTEE ON RAPID RESPONSES TO STEROID HORMONES (RRSH)"

CHANNELS AND TRANSPORTERS IN IMMUNITY - PROJECT SUMMARY ION CHANNELS AND TRANSPORTERS (ICTS) CONSTITUTE APPROXIMATELY 25% OF ALL FDA-APPROVED DRUG TARGETS, YET PARADOXICALLY, NOT A SINGLE ICT-TARGETED THERAPY EXISTS FOR IMMUNE DISORDERS DESPITE THEIR CRITICAL ROLES IN IMMUNE CELL FUNCTION. THIS GLARING THERAPEUTIC GAP PERSISTS DUE TO FORMIDABLE INTERDISCIPLINARY BARRIERS: IMMUNOLOGISTS LACK BIOPHYSICAL TRAINING TO INTERPRET ELECTROPHYSIOLOGY DATA, WHILE CHANNEL PHYSIOLOGISTS RARELY APPRECIATE IMMUNE SIGNALING COMPLEXITY. THE 2026 FASEB SCIENCE RESEARCH CONFERENCE ON CHANNELS AND TRANSPORTERS IN IMMUNITY WILL SERVE AS THE WORLD'S ONLY DEDICATED INTERNATIONAL VENUE BRIDGING THESE SILOS, BUILDING ON OUR INAUGURAL 2024 MEETING'S REMARKABLE SUCCESS (106 PARTICIPANTS FROM 9 COUNTRIES, 4.5/5 SATISFACTION RATINGS, MULTIPLE NEW COLLABORATIONS). THE 2026 CONFERENCE (JULY 12-16, SHERATON NIAGARA FALLS) WILL AMPLIFY THIS MOMENTUM THROUGH STRATEGIC INNOVATIONS: NEARLY COMPLETE SPEAKER REFRESH ENSURING CUTTING- EDGE PERSPECTIVES, DYNAMIC LATE-BREAKING SLOTS CAPTURING BREAKTHROUGH DISCOVERIES, UNPRECEDENTED TRAINEE EMPOWERMENT WITH 30% OF PODIUM TIME, AND STRATEGIC CO-LOCATION WITH THE FASEB SRC ON IMMUNORECEPTORS AND IMMUNOTHERAPY TO MAXIMIZE INTERDISCIPLINARY EXCHANGE. OUR PROGRAM WILL PROGRESS SYSTEMATICALLY FROM METHODOLOGICAL ADVANCES THROUGH MECHANISTIC INSIGHTS TO TRANSLATIONAL APPLICATIONS, MIRRORING THE DRUG DEVELOPMENT PIPELINE. THREE SPECIFIC AIMS WILL GUIDE OUR EFFORTS: (1) DISSEMINATE CUTTING-EDGE DISCOVERIES IN ICT STRUCTURE, FUNCTION, AND THERAPEUTIC TARGETING THROUGH SIX THEMATIC SESSIONS INTEGRATING DIVERSE DISCIPLINARY PERSPECTIVES; (2) IGNITE THE NEXT GENERATION OF ICT-IMMUNITY RESEARCHERS BY DEDICATING UNPRECEDENTED RESOURCES TO TRAINEE DEVELOPMENT, INCLUDING TRAVEL AWARDS, STRUCTURED MENTORING, AND AN INTIMATE CONFERENCE ENVIRONMENT FOSTERING LASTING COLLABORATIONS; AND (3) ACCELERATE TRANSLATION OF ICT DISCOVERIES INTO IMMUNOTHERAPIES THROUGH DEDICATED PROGRAMMING ON DRUG DEVELOPMENT, PHARMACEUTICAL INDUSTRY ENGAGEMENT, AND STRUCTURED DIALOGUES ADDRESSING BARRIERS TO CLINICAL TRANSLATION. LED BY DR. BIMAL DESAI (UVA) AND DR. AXEL CONCEPCION (U CHICAGO), THIS CONFERENCE WILL TRANSFORM ICT-IMMUNITY FROM AN OVERLOOKED NICHE INTO A VIBRANT THERAPEUTIC FRONTIER. BY PROVIDING THE ESSENTIAL PLATFORM FOR INTERDISCIPLINARY CONVERGENCE, TRAINEE DEVELOPMENT, AND TRANSLATIONAL ADVANCEMENT, WE WILL CATALYZE THE DISCOVERY OF PRECISE, TISSUE-SPECIFIC IMMUNOMODULATORS FOR MILLIONS SUFFERING FROM INFLAMMATION, AUTOIMMUNITY, AND CANCER.

FASEB SRC ON TGF-BETA SUPERFAMILY: SIGNALING IN DEVELOPMENT AND DISEASE

FASEB SRC ON PROTEIN PHOSPHATASES

FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES

CONFERENCE: FASEB SCIENCE RESEARCH CONFERENCE: GENETIC RECOMBINATION AND GENOME REARRANGEMENTS -THIS AWARD WILL PROVIDE SUPPORT FOR THE 2026 FEDERATION OF AMERICAN SOCIETIES OF EXPERIMENTAL BIOLOGY (FASEB) SCIENCE RESEARCH CONFERENCE ON ?GENETIC RECOMBINATION AND GENOME REARRANGEMENTS?, TO BE HELD JULY 12-17, 2026, IN SCOTTSDALE, ARIZONA. THE CONFERENCE ADDRESSES A UNIQUE NEED IN THE FIELD. IT BRINGS TOGETHER RESEARCHERS FOCUSED ON ?GENETIC RECOMBINATION?: THE PROCESS BY WHICH A BROKEN DNA MOLECULE INTERACTS WITH ANOTHER DNA MOLECULE TO ENABLE ITS REPAIR THAT IMPACT THE DEVELOPMENT OF BIOTECHNOLOGIES RELEVANT TO UNDERSTANDING AND TREATING CANCER AND OTHER HUMAN DISEASES. THE PRIMARY GOALS OF THE CONFERENCE ARE TO SHARE CUTTING-EDGE INSIGHTS INTO RECOMBINATION AND TO FOSTER NEW COLLABORATIONS, LEADING TO A DEEPER UNDERSTANDING OF THE PROCESS. MORE BROADLY, THE CONFERENCE WILL EDUCATE TRAINEES AND HELP THEM TO NETWORK WITH LEADERS IN THE FIELD FOR CAREER DEVELOPMENT IN BIOTECHNOLOGY AND STEM CAREERS. THE CONFERENCE WILL COVER A BROAD RANGE OF TOPICS, FROM STRUCTURAL AND BIOPHYSICAL ANALYSES OF RECOMBINATION ENZYMES TO WHOLE-GENOME ANALYSIS OF MUTAGENESIS, GENOME REARRANGEMENTS AND TELOMERE MAINTENANCE, WITH STUDIES PERFORMED IN A BROAD ARRAY OF MODEL SYSTEMS. THESE STUDIES ARE RELEVANT TO PHYSIOLOGICAL PROCESSES SUCH AS MEIOSIS AND ALSO TO BIOTECHNOLOGY DEVELOPMENT THAT CAN IMPACT HUMAN DISEASE, NOTABLY CANCER AND AGING. THE CONFERENCE WILL FEATURE UNPUBLISHED RESEARCH ON CUTTING-EDGE QUESTIONS THAT DRIVE THE FIELD FORWARD. THE PROGRAM INCLUDES TALKS AND POSTER PRESENTATIONS FROM TRAINEES, EARLY-STAGE INVESTIGATORS AND SENIOR SCIENTISTS. ALL ATTENDEES ARE ENCOURAGED TO PARTICIPATE BY PRESENTING A POSTER OR AN INVITED/SELECTED ORAL PRESENTATION AND BY PARTICIPATING IN POSTER SESSIONS AND SOCIAL EVENTS. THE CONFERENCE DESIGN ENCOURAGES FORMAL AND INFORMAL DISCUSSIONS THAT WILL PROMOTE NEW COLLABORATIONS AND WELCOME NEWCOMERS TO THE RESEARCH COMMUNITY, INCLUDING YOUNG INVESTIGATORS AND TRAINEES. SUCCESSFUL OUTCOMES OF THE CONFERENCE WILL INCLUDE NEW COLLABORATIONS THAT DRIVE THE FIELD FORWARD. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

FASEB SUMMER RESEARCH CONFERENCE 2008 - MELATONIN RECEPTORS: ACTIONS AND THERAPEU

RENAL HEMODYNAMICS: MECHANISMS TO UNDERSTAND DISEASE

FASEB SRC: TRACE ELEMENTS IN BIOLOGY AND MEDICINE

FASEB SUMMER CONFERENCE ON PROTEIN PHOSPHATASES

UBIQUITIN AND CELLULAR REGULATION

REGULATION & FUNCTION OF SMALL GTPASES

FASEB SRC ON MEMBRANE ORGANIZATION BY MOLECULAR SCAFFOLDS

CONFERENCE: FASEB 2024 CONFERENCE ON GENETIC RECOMBINATION AND GENOME REARRANGEMENTS -THIS AWARD IS FOR SUPPORT OF THE CONFERENCE GENETIC RECOMBINATION AND GENOME REARRANGEMENTS, TO BE HELD JULY 14-19 2024 IN TUCSON, ARIZONA. THIS IS A WELL-ESTABLISHED CONFERENCE THAT HAS OCCURRED BIENNIALLY SINCE 1985. THE MEETING WILL INCLUDE 8 PLENARY SESSIONS, EACH OF WHICH WILL HAVE 5 TO 8 20 MINUTE PRESENTATIONS. APPROXIMATELY TWO-THIRDS OF THE SPEAKERS ARE BY INVITATION, AND THE REMAINDER WILL BE SELECTED FROM CONTRIBUTED ABSTRACTS, WITH AN EMPHASIS ON EARLY CAREER SCIENTISTS. IN ADDITION, APPROXIMATELY 70 JUNIOR PARTICIPANTS GIVING POSTERS WILL ALSO BE GIVING SHORT POSTER PRIMER TALKS, INTRODUCING THEMSELVES AND THEIR POSTER TOPICS. THIS MEETING WILL HAVE OVER 200 PARTICIPANTS REPRESENTING ALL CAREER STAGES, FROM TRAINEES TO ESTABLISHED PI?S. THE ORGANIZING COMMITTEE WILL MAKE A SPECIAL EFFORT TO PROVIDE PLENARY SPEAKING OPPORTUNITIES TO DIVERSE JUNIOR SCIENTISTS AS WELL. NOTABLY, ALL NSF FUNDS WILL BE USED TO SUPPORT PARTICIPATION BY TRAINEES AND YOUNG INVESTIGATORS, WITH AN EMPHASIS ON THOSE FROM HISTORICALLY UNDERREPRESENTED GROUPS AS WELL AS THOSE WITH FINANCIAL NEED. THE CONFERENCE WILL FOCUS ON THE TOPIC OF RECOMBINATION AND ITS IMPLICATIONS FOR GENOME REARRANGEMENT, MUTATION, DNA REPAIR AND CHROMOSOME FUNCTION. THESE TOPICS WILL BE EXPLORED FROM MULTIPLE, MECHANISTIC PERSPECTIVES, INCLUDING STRUCTURAL AND BIOPHYSICAL ANALYSES OF THE PROTEINS INVOLVED IN RECOMBINATION, AND GENOMIC ANALYSES OF THE CONSEQUENCES OF RECOMBINATION FOR GENOME STRUCTURE. THE MEETING WILL EMPHASIZE BREAKTHROUGHS SPURRED BY CUTTING-EDGE APPROACHES USING MOLECULAR GENETICS, BIOCHEMISTRY AND STRUCTURAL BIOLOGY, AS APPLIED TO DNA DAMAGE RESPONSES, CHROMATIN REMODELING, AND THE GENERAL PROCESSES OF REPLICATION, TRANSCRIPTION AND RECOMBINATION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

FASEB SRC ON TRANSLATIONAL NEUROIMMUNOLOGY: FROM MECHANISMS TO THERAPEUTICS

FASEB CONFERENCE ON MECHANISMS IN PLANT DEVELOPMENT, SAXTON'S RIVER, VERMONT, AUGUST 2 - 7, 2015

DYNAMICS AND ENCODING IN SIGNAL TRANSDUCTION - PROJECT SUMMARY CELL COMMUNICATION RESEARCH IS A GROWING FIELD THAT IS COMPLIMENTARY TO, BUT DISTINCT FROM, TRADITIONAL SIGNAL TRANS- DUCTION FIELDS. THIS EMERGING FIELD EMPHASIZES THE SPATIOTEMPORAL ASPECTS OF CELL COMMUNICATION AND QUANTITATIVE UNDERSTANDING OF HOW INFORMATION TRANSMISSION AND PROCESSING OCCURS. A CENTRAL FOCUS ON THE FIELD IS TO UNDER- STAND EXACTLY WHAT DISTINGUISHES “NORMAL” AND “DISEASE” CELL SIGNALING BEHAVIOR IN TERMS OF SPATIAL AND TEMPORAL DETAILS. THERE ARE AT LEAST 80 LABS WORLDWIDE THAT USE LIVE CELL IMAGING, GENETICALLY ENCODED BIOSENSORS, COMPU- TATIONAL IMAGE ANALYSIS, AND MATHEMATICAL MODELS TO DETERMINE MODERN QUANTITATIVE CONCEPTS FOR CELL COMMUNI- CATION. HOWEVER, THERE IS NOT A CURRENTLY EXISTING “HOME” CONFERENCE FOR BIOMEDICAL SCIENTISTS WORKING IN THIS FIELD, LIMITING CROSS-FERTILIZATION OF SHARED HIGHER-LEVEL CONCEPTS ACROSS THE MANY PATHWAYS STUDIED IN THE FIELD, INCLUDING IMMUNE SIGNALING, RECEPTOR-MEDIATED SIGNAL TRANSDUCTION, GENE EXPRESSION, CELL CYCLE, AND METABOLIC SIGNALING PATHWAYS. THEREFORE, THERE IS AN URGENT NEED FOR A CONFERENCE WHICH CAN BRING TOGETHER THE DIVERSITY OF GROUPS IN THE CELL COMMUNICATION FIELD TO SHARE IDEAS AND DEVELOPMENT OF WORK FOCUSING ON HOW CELL COMMUNICATION OCCURS NORMALLY AND IS PERTURBED BY DISEASE. TO ADDRESS THIS NEED, WE ARE FACILITATING A NEW CONFERENCE, THE 2024 DYNAMICS AND ENCODING IN CELL SIGNALING FASEB SCIENTIFIC RESEARCH CONFERENCE. FOR THE FIRST TIME, WE WILL BRING TOGETHER IN-PERSON AN INTERNATIONAL COMMUNITY IN THE CELL COMMUNICATION FIELD. TO ACCOMPLISH THIS, WE AIM TO (1) PROVIDE STRUCTURE FOR AN EMERGING RESEARCH FIELD BY ESTABLISHING AND BUILDING RELATIONSHIPS AND COLLAB- ORATIONS BETWEEN SENIOR SCIENTISTS AND EARLY CAREER RESEARCHERS THROUGH NETWORKING OPPORTUNITIES AND A SPEAKER LINEUP INCLUDING BOTH EARLY CAREER RESEARCHERS AND ESTABLISHED LEADERS. THIS INCLUDES 20 TRAINEE TALKS OVER THE COURSE OF THE CONFERENCE. LIGHTENING TALKS WILL HIGHLIGHT TRAINEE POSTERS AND ENCOURAGE INTERACTIONS AND NETWORK- ING AT POSTER SESSIONS BETWEEN TRAINEES AND ESTABLISHED INVESTIGATORS. WE AIM TO (2) PROVIDE TRAINEES WITH KNOWLEDGE, NETWORKS, AND MENTORS FOR CAREER OPPORTUNITIES THROUGH MEETINGS AND NETWORKING OPPORTUNITIES WITH ESTABLISHED RESEARCHERS IN BOTH INDUSTRY AND ACADEMIA. THIS FIRST ITERATION OF THE MEETING WILL AIM TO (3) CREATE NEW MODELS BY CONNECTING RESEARCHERS INTERESTED IN RELATED CONCEPTS ACROSS BIOLOGICALLY DIFFERENT SIGNALING AND REGULATORY SYSTEMS, PROVIDING OPPORTUNITIES FOR RESEARCHERS TO THINK OUTSIDE THE TYPICAL BOUNDARIES OF THEIR WORK AND FIND NEW INSIGHTS FROM COLLEAGUES IN PARALLEL FIELDS. WE WILL ALSO AIM TO (4) PROMOTE ACCESS TO NEW IMAGE ANALYSIS AND MODELING TECHNOLOGIES BY EMPHASIZING THE LATEST TECHNICAL ADVANCES IN THESE AREAS. THE CONFER- ENCE WILL ALSO HIGHLIGHT THE DIVERSITY OF THE FIELD AS OUT OF OUR 31 INVITED SPEAKERS, 13 ARE WOMEN AND 10 ARE FROM INSTITUTIONS OUTSIDE THE UNITED STATES. ALTOGETHER, THE DYNAMICS AND ENCODING IN CELL SIGNALING FASEB SCIENTIFIC RESEARCH CONFERENCE PROVIDES A MUCH NEEDED AND EXCITING FORUM FOR THE CELL COMMUNICATION FIELD AND WILL EN- ABLE CROSS-DISCIPLINARY COLLABORATIONS AND INSIGHTS INTO CELL FUNCTION AND BEHAVIOR THAT IS NOT CURRENTLY POSSIBLE.

FASEB'S THE NUTRITION, IMMUNITY, AND INFLAMMATION CONFERENCE: FROM MODEL SYSTEMS TO HUMAN TRIALS - PROJECT SUMMARY/ABSTRACT “THE NUTRITION, IMMUNITY AND INFLAMMATION CONFERENCE: FROM MODEL SYSTEMS TO HUMAN TRIALS” WAS SELECTED BY FASEB FOR THEIR SCIENCE RESEARCH CONFERENCE (SRC) SERIES AND WILL BE HELD IN 2021 FROM JULY 25-29 AT THE WESTIN SNOWMASS RESORT IN SNOWMASS, CO. THIS IS THE SIXTH OCCURRENCE OF THE CONFERENCE, WHICH HAS TRADITIONALLY HIGHLIGHTED MECHANISTIC RESEARCH, INCLUDING CLINICAL STUDIES, EXAMINING THE ROLE OF SPECIFIC NUTRIENTS ON IMMUNE FUNCTION AND HOST RESISTANCE. CONTINUING THIS TRADITION, WE WILL FOCUS ON THE EFFECT OF NUTRITION ON INNATE AND ADAPTIVE IMMUNITY IN MODEL SYSTEMS AND HUMAN TRIALS. NEW ADDITIONS TO THE CONFERENCE THIS YEAR, DESIGNED TO EXPAND THE BASE OF ATTENDEES FROM PREVIOUS YEARS, INCLUDE A SESSION ON “NUTRITIONAL IMMUNITY”, WHICH WILL EXAMINE THE COMPETITION BETWEEN HOST AND PATHOGEN FOR ESSENTIAL NUTRIENTS, PARTICULARLY MINERALS SUCH AS IRON AND ZINC. THIS SESSION WILL BRING A DISTINCT HOST-PATHOGEN FOCUS IN ADDITION TO TALKS ON THE ROLE OF DIET IN ESTABLISHING THE COMMENSAL MICROBIOME. ANOTHER NEW FOCUS INCLUDES EXAMINATION OF THE ASSOCIATION OF DIETARY PATTERNS WITH DEVELOPMENT OF INFLAMMATION-RELATED METABOLIC DISEASES, THUS BRINGING AN EPIDEMIOLOGICAL AND CLINICAL FOCUS TO THE CONFERENCE. WE ARE EXPANDING OUR FUNDING REQUEST TO PROVIDE SUPPORT FOR STUDENTS AND EARLY CAREER INVESTIGATORS. THIS IS CONSISTENT WITH A SPECIFIC AIM OF THE CONFERENCE THIS YEAR TO CREATE OPPORTUNITIES FOR STUDENTS AND EARLY CAREER INVESTIGATORS, PARTICULARLY OF DIVERSE AND UNDERREPRESENTED BACKGROUNDS, TO DEVELOP CONNECTIONS WITH EACH OTHER AND WITH MORE SENIOR INVESTIGATORS AS NETWORKING IS IMPORTANT FOR CAREER DEVELOPMENT. FINALLY, INFORMATION FROM THE MEETING WILL BE DISSEMINATED IN A SPECIAL ISSUES OF A LEADING JOURNAL THAT WILL FEATURE REVIEW ARTICLES FROM THE SPEAKERS.

PROTEIN FOLDING IN THE CELL

FASEB SUMMER CONFERENCE ON 'AUTOIMMUNITY'

HIPPO PATHWAY IN BIOLOGY AND DISEASES - PROJECT SUMMARY THIS APPLICATION REQUESTS FUNDING SUPPORT FOR EARLY-CAREER RESEARCHERS (PHD STUDENTS, POSTDOCTORAL FELLOWS AND JUNIOR FACULTY) TO ATTEND FOR THE 2026 FASEB SCIENTIFIC RESEARCH CONFERENCE: HIPPO PATHWAY IN BIOLOGY AND DISEASES, TO BE HELD SEPTEMBER 1–4, 2026 AT THE FORT GARRY HOTEL, SPA & CONFERENCE CENTRE IN WINNIPEG, CANADA. ORGANIZED BY DRS. ANWESHA DEY, KENNETH IRVINE, KUN-LIANG GUAN, AND WENQI WANG, THIS FOUR-DAY MEETING WILL BRING TOGETHER HIPPO SIGNALING RESEARCHERS FROM AROUND THE WORLD. THE HIPPO PATHWAY FUNCTIONS IN NUMEROUS PHYSIOLOGICAL PROCESSES AND IS FREQUENTLY DYSREGULATED IN CANCER AND OTHER DISEASES. WE WILL CONVENE AN OUTSTANDING AND BROAD GROUP OF SCIENTISTS WORKING AT THE FOREFRONT OF THE HIPPO FIELD TO GAIN NEW INSIGHTS INTO THE HIPPO PATHWAY IN BIOLOGICAL PROCESSES, ITS ALTERATION IN CANCER AND OTHER DISEASES, AND ADVANCES IN THERAPIES TARGETING THE HIPPO PATHWAY. INVESTIGATORS WORKING ON HIPPO SIGNALING REMAIN DISPERSED ACROSS DISCIPLINES, DISEASE AREAS, AND CONTINENTS, AND GIVEN THE RAPID ADVANCEMENTS AND BREADTH OF THE FIELD A REGULAR CONFERENCE DEDICATED TO THIS PATHWAY IS GREATLY NEEDED. THE PROGRAM WILL INCLUDE A KEYNOTE LECTURE, THEMED SCIENTIFIC SESSIONS, PLENARY TALKS, SHORT TALKS AND LIGHTNING TALKS, POSTER SESSIONS, A “MEET THE HIPPO EXPERTS” WORKSHOP, AND PARALLEL CAREER DEVELOPMENT WORKSHOPS TAILORED TO TRAINEES AND JUNIOR FACULTY. THROUGH THIS PROGRAM, WE AIM TO 1) STIMULATE SCIENTIFIC EXCHANGE AND CATALYZE NEW COLLABORATIONS FOR SCIENTISTS, CLINICIANS, NONPROFITS, AND INDUSTRY PARTNERS SHARING AND DISCUSSING CUTTING-EDGE RESEARCH ON HIPPO PATHWAY REGULATION, FUNCTION, AND THERAPY; 2) ADVANCE THE CAREERS OF EARLY-STAGE INVESTIGATORS BY PROVIDING NETWORKING AND PROFESSIONAL DEVELOPMENTAL OPPORTUNITIES FOR EARLY-CAREER RESEARCHERS AND JUNIOR FACULTY, PROMOTING PARTICIPATION AND ENGAGEMENT THROUGH PRESENTATION OPPORTUNITIES, TRAVELING AWARDS, AND POSTER/WORKSHOP DISCUSSIONS; AND 3) DISSEMINATE THE LATEST DISCOVERIES IN THE FIELD AND ESTABLISH A RECURRING CONFERENCE SERIES BY PUBLISHING THE PROCEEDINGS OF THE CONFERENCE, BOOSTING NEW COLLABORATIONS, AND PROVIDING A REGULAR FORUM FOR EXCHANGE AND TRAINING. R13 SUPPORT WILL BE USED PRIMARILY TO PROVIDE 20 TRAVEL AWARDS FOR PHD STUDENTS, POSTDOCTORAL FELLOWS, AND BEGINNING ASSISTANT PROFESSORS. BY FOSTERING SCIENTIFIC EXCHANGE, CATALYZING NEW COLLABORATIONS, AND PROVIDING STRUCTURED MENTORING, NETWORKING, AND PROFESSIONAL DEVELOPMENT OPPORTUNITIES, THIS FASEB CONFERENCE WILL HAVE A MAJOR IMPACT ON THE FIELD, ACCELERATING ADVANCES IN HIPPO SIGNALING AND ITS APPLICATION TO CANCER, REGENERATIVE MEDICINE AND DISEASES OF HIGH

CONFERENCE: FASEB CONFERENCE ON CHROMOSOME BIOLOGY AND CELL STATES IN YEASTS 2026 -THIS AWARD WILL PROVIDE SUPPORT FOR THE 2026 FASEB CONFERENCE: ?CHROMOSOME BIOLOGY AND CELL STATES IN YEASTS?, JULY 27-29. THE MEETING OCCURS EVERY TWO YEARS AND ATTRACTS THE BEST SCIENTISTS IN THE FIELD FROM AROUND THE WORLD. THE MEETING INCLUDES TALKS THAT DESCRIBE EXCITING NEW FINDINGS FROM BOTH INVITED SPEAKERS AND MIX OF TRAINEES, YOUNG INVESTIGATORS, AND SENIOR SCIENTISTS. THERE ARE ACCOMPANYING POSTER SESSIONS WHERE ALL ATTENDEES CAN PRESENT THEIR RECENT FINDINGS. ADDITIONALLY, ALL TRAINEES ARE INVITED TO PRESENT A ?FLASH TALK? TO DESCRIBE THEIR RESEARCH. A LONGSTANDING GOAL OF THE MEETING IS TO PROVIDE NETWORKING, COLLABORATION, AND LEARNING OPPORTUNITIES TO HELP BUILD A STRONG WORKFORCE OF SCIENTISTS IN THIS FIELD AND BIOTECHNOLOGY. THE MEETING INCLUDES A ?MEET THE EXPERT? SESSION WHERE YOUNG SCIENTISTS CAN MEET ESTABLISHED RESEARCHERS TO DISCUSS THEIR RESEARCH AND CAREER GOALS, AND A CAREER DEVELOPMENT SESSION THAT SUPPORTS NEW INVESTIGATORS. THIS MEETING BRINGS TOGETHER SCIENTISTS WHO USE VARIOUS YEAST SPECIES TO STUDY TWO BROAD QUESTIONS THAT ARE CENTRAL TO ALL LIFE FORMS: 1. HOW DO ARE CHROMOSOMES FAITHFULLY DUPLICATED AND PARTITIONED? AND 2. HOW DO CELLS CONTROL THEIR GROWTH AND DIVISION? TOPICS COVERED AT THE MEETING INCLUDE DNA REPLICATION AND REPAIR, CHROMOSOME STRUCTURE AND FUNCTION, CELL GROWTH AND DIVISION, AND GENOME EVOLUTION. THE METHODOLOGIES USED RANGE FROM COMPUTATIONAL SCIENCE AND ADVANCED IMAGING TO POPULATION BIOLOGY AND MOLECULAR GENETICS THAT HAVE IMPLICATIONS FOR BIOTECHNOLOGY DEVELOPMENTS. IN SUMMARY, THIS LONG-STANDING MEETING CONTINUES TO GROW AND CHANGE TO SHARE EMERGING SCIENTIFIC INFORMATION ON THE CRITICAL TOPICS OF CHROMOSOME BIOLOGY AND CELL GROWTH, AND TO BUILD A STRONG STEM BIOTECHNOLOGY WORKFORCE FOR THE FUTURE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

THE PROTEIN AGGREGATION CONFERENCE: EXPLORING RUGGED LANDSCAPES - PROJECT SUMMARY PROTEIN AGGREGATION IS CRITICAL TO BOTH NORMAL AND PATHOLOGICAL BIOLOGICAL PHENOMENA. INAPPROPRIATE PROTEIN AGGREGATION UNDERPINS MANY NEUROLOGICAL AND SYSTEMIC DISEASES, ESPECIALLY THOSE ASSOCIATED WITH AGING. DESPITE ENORMOUS PROGRESS IN THE ADVANCEMENT OF KNOWLEDGE FOR HOW PROTEIN AGGREGATION RELATES TO DISEASE PATHOGENESIS THERE REMAIN FEW EFFECTIVE THERAPIES FOR THESE DISEASES - ESPECIALLY RELATIVE TO THE SUCCESSES IN CARDIOVASCULAR DISEASES AND CANCER. RECENT DISCOVERIES HAVE UNEARTHED NUMEROUS EXAMPLES OF FUNCTIONAL PROTEIN AGGREGATION IN MEMBRANELESS ORGANELLES AND SIGNALING PATHWAYS. THE STRUCTURAL BASES OF SUCH PHENOMENA INCLUDE NOT ONLY AMYLOIDS AND OTHER ORDERED POLYMERS BUT ALSO LIQUID-LIQUID PHASE SEPARATION. THE MECHANISMS AND REGULATION OF THESE FORMS OF AGGREGATION ARE STILL BEING DECIPHERED, BUT ARE ALREADY ILLUMINATING FRUITFUL INTERSECTIONS WITH PATHOLOGICAL AGGREGATION. THESE NEW DIRECTIONS IN THE FIELD PLACE PROTEIN AGGREGATION AT AN ENERGETIC AND EXCITING MOMENT OF PROGRESS. THIS R13 PROPOSAL SEEKS SUPPORT FOR A FASEB SUMMER RESEARCH CONFERENCE ON “PROTEIN AGGREGATION: EXPLORING RUGGED LANDSCAPES”. THIS WILL BE THE FOURTEENTH CONFERENCE OF A SERIES THAT BEGAN IN 1995. OUR 4-DAY PROGRAM WILL BRING THE BEST RESEARCHERS ON THE MOST CUTTING- EDGE TOPICS OF THE DISCIPLINE, WHILE EMPHASIZING DIVERSITY, EQUITY, AND INCLUSION. WE WILL USE THE R13 FUNDING TO SUPPORT THESE MEASURES AND FURTHER INCREASE ENGAGEMENT BY JUNIOR RESEARCHERS.

FASEB'S THE ION CHANNEL REGULATION CONFERENCE - THIS IS AN APPLICATION FOR PARTIAL SUPPORT OF THE 10TH BIENNIAL FASEB SCIENCE RESEARCH CONFERENCE ON ION CHANNEL REGULATION THAT WILL BE HELD FROM JUNE 27 TO JULY 2 2021 AT THE OAK ISLAND RESORT & CONFERENCE CENTER IN NOVA SCOTIA, CANADA. THE OBJECTIVES OF THIS CONFERENCE ARE TO: STIMULATE DISCOURSE, SEED NEW IDEAS, AND FACILITATE COLLABORATION IN WAYS THAT WILL ACCELERATE NEW DISCOVERIES ABOUT ION CHANNELS AT THE BASIC AND TRANSLATIONAL LEVELS, AND TO PROVIDE A FORUM FOR TRAINEES TO PARTICIPATE IN SCIENTIFIC SESSIONS AND IN CAREER DEVELOPMENT ACTIVITIES. REGULATION OF ION CHANNEL FUNCTION IS ESSENTIAL FOR MYRIAD PHYSIOLOGICAL FUNCTIONS INCLUDING NEURONAL SIGNALING, PAIN TRANSDUCTION, AND THE BEATING OF THE HEART. ACCOUNTING FOR ~2% OF HUMAN GENES, ION CHANNELS ARE SUBJECT TO NUMEROUS DISEASE-CAUSING MUTATIONS, LEADING TO OVER 55 INHERITED DISORDERS TERMED “CHANNELOPATHIES”, INCLUDING EPILEPSY, MIGRAINE, SEVERAL NEUROLOGICAL DISORDERS, BLINDNESS, DEAFNESS, DIABETES, HYPERTENSION, SEVERAL DIFFERENT CARDIAC ARRHYTHMIAS, ASTHMA, IRRITABLE BOWEL SYNDROME, SKIN DISEASES AND CANCER. IMPORTANTLY, CONSIDERING THE CENTRAL INVOLVEMENT OF ION CHANNELS, THESE DISEASES SHARE A GREAT DEAL IN COMMON IN TERMS OF DISEASE MECHANISMS AND POTENTIAL THERAPEUTIC DEVELOPMENT WITH ION CHANNELS BEING THE TARGET OF NUMEROUS DRUGS. THUS, THE TOPIC OF OUR CONFERENCE IS BOTH TIMELY AND HIGHLY RELEVANT FOR A BROAD POPULATION OF SCIENTISTS, CLINICIANS, AND THE GENERAL PUBLIC AND WILL BENEFIT GREATLY FROM THE ION CHANNEL COMMUNITY COMING TOGETHER. THE MEETING WILL BE CO-CHAIRED BY ISABELLE DESCHÊNES FROM THE OHIO STATE UNIVERSITY AND GEA-NY TSENG FROM VIRGINIA COMMONWEALTH UNIVERSITY, BOTH RECOGNIZED LEADERS IN ION CHANNEL BIOLOGY WITH EXPERTISE BETWEEN THE TWO OF THEM COVERING ALL ASPECTS OF ION CHANNEL RESEARCH GOING FROM STRUCTURE-FUNCTION, TRANSCRIPTIONAL REGULATION, TRAFFICKING, REGULATION AND CHANNELOPATHIES. THE PROGRAM CONSISTS OF NINE SCIENTIFIC SESSIONS, TWO KEYNOTE ADDRESSES, AND TWO BREAKOUT SESSIONS FOCUSED ON INTERACTIONS WITH EXPERTS FROM ACADEMIA, NIH AND INDUSTRY AND A CAREER DEVELOPMENT SESSION. MOST SCIENTIFIC SESSIONS ARE ORGANIZED AROUND GENERAL THEMES RATHER THAN ION CHANNEL SUBTYPE AND ORGANS, TO FOSTER CROSSTALK BETWEEN FIELDS TYPICALLY KEPT SEPARATE IN TRADITIONAL CONFERENCES. THERE WILL BE 32 SESSION SPEAKERS GIVING FULL TALKS, INCLUDING AT LEAST 18 WOMEN (56% OF SPEAKERS) AND 9 SESSION CHAIRS (4 OF WHOM ARE WOMEN, 44%). MOST OF THE INVITED SPEAKERS (90%) HAVE NOT PRESENTED AT THIS CONFERENCE DURING THE PRIOR TWO MEETINGS. OF THE 32 SESSION SPEAKERS, WE CURRENTLY HAVE 9 EARLY CAREER STAGE INVESTIGATORS (28%) AND 9 MEMBERS OF UNDER-REPRESENTED MINORITIES IN SCIENCE (28%). WE WILL ALSO HAVE 8 ADDITIONAL SHORT TALKS WHICH WILL BE SELECTED FROM THE ABSTRACTS SUBMITTED AND DEDICATED TO JUNIOR INVESTIGATORS WHICH WILL THEREFORE ENCOMPASS 36% OF OUR SPEAKERS, GIVING THEM THE OPPORTUNITY TO GET BROAD EXPOSURE. WE HAVE PLACED EMPHASIS ON COMPREHENSIVE SCIENTIFIC THEMES SHARED ACROSS ION CHANNEL TYPES SEEKING TO CATALYZE ON THE KNOWLEDGE FROM EACH TO BENEFIT THE BROADER FIELD AND WILL ALLOW US TO BUILD MULTIDISCIPLINARY NETWORKS ACROSS THE DIFFERENT ION CHANNELS.

FASEB SRC ON PROTEIN AGGREGATION, FROM STRUCTURAL VARIANTS TO IN VIVO SEQUELA

FASEB SRC ON CALCIUM AND CELL FUNCTION

FASEB SRC ON ION CHANNEL REGULATION

FASEB SRC ON MELATONIN RECEPTORS: ACTIONS AND THERAPEUTICS

NEURAL-IMMUNE INTERACATIONS: PATHOLOGY AND MOLECULAR MECHANISMS OF REPAIR

FASEB SRC ON FUNCTIONAL DISULFIDE BONDS IN HEALTH AND DISEASE

FASEB SRC: THE LUNG EPITHELIUM IN HEALTH & DISEASE

FASEB SRC ON LIPID DROPLETS ON THE MOVE FROM HEALTH TO DISEASE

FASEB SRC ON LIPID DROPLETS: DYNAMIC ORGANELLES IN METABOLISM AND BEYOND

FASEB SRC ON GLUCOSE TRANSPORT:GATEWAY TO METABOLIC SYSTEMS BIOLOGY

FASEB SRC ON MOLECULAR MECHANISMS OF INTESTINAL LIPID ABSORPTION

FASEB SRC ON GLUCOSE TRANSPORT: GATEWAY FOR METABOLIC SYSTEMS BIOLOGY

FASEB SRC ON LIPID DROPLETS: METABOLIC CONSEQUENCES OF THE STORAGE OF NEUTRAL LIP

FASEB SRC ON LIVER BIOLOGY: FUNDAMENTAL MECHANISMS & TRANSLATIONAL APPLICATION

FASEB SRC ON GLUCOSE TRANSPORTERS, SIGNALING AND DIABETES

LIPID DROPLETS: METABOLIC CONSEQUENCES OF THE STORAGE OF NEUTRAL LIPIDS

DYNAMIC STRUCTURE OF THE NUCLEAR HORMONE RECEPTORS

LIVER BIOLOGY, DEVELOPMENT AND DISEASE

EXTRA-NUCLEAR STEROID RECEPTORS: INTEGRATION WITH MULTIPLE SIGNALING PATHWAYS

RNA PROCESSING IN CANCER: FROM BENCH TO BEDSIDE - ALTERATIONS IN RNA PROCESSING HAVE RECENTLY EMERGED AS BOTH BIOMARKERS AND DRIVERS OF CANCER, AND REPRESENT A PROMISING TARGET FOR NOVEL CANCER THERAPIES. THUS, THERE IS A NEED FOR MEETINGS THAT BRING TOGETHER EXPERTS AND TRAINEES IN RNA BIOLOGY AND CANCER TO LEAD THE INTEGRATION OF NOVEL FINDINGS IN THESE FIELDS THAT WILL CATALYZE NOVEL THERAPEUTIC DEVELOPMENT AND PREPARE THE NEXT GENERATION OF SCIENTISTS AND PHYSICIANS TO UNCOVER HOW RNA CAN BE THERAPEUTICALLY TARGETED. TO FILL THIS GAP, WE ARE ORGANIZING THE UNIQUE AND TIMELY INTERDISCIPLINARY CONFERENCE “2025 FASEB RNA PROCESSING IN CANCER: FROM BENCH TO BEDSIDE” MEETING, IN ORDER TO FOSTER FUTURE COLLABORATIONS AND RESEARCH ADVANCES. BUILDING UPON THE SUCCESS OF THE INAUGURAL 2023 MEETING, THE MAIN OBJECTIVES OF THIS MEETING ARE TO SHARE NOVEL RESEARCH FINDINGS THAT DEFINE THE ROLE OF RNA PROCESSING IN CANCER INITIATION, PROGRESSION, AND DRUG RESPONSES, AND TO IDENTIFY NOVEL THERAPEUTIC STRATEGIES TO TARGET RNA PROCESSING DEFECTS IN CANCER. THIS 5-DAY LONG CONFERENCE TO BE HELD IN SACRAMENTO, CA IN OCTOBER 2025 WILL BRING TOGETHER SCIENTISTS, INCLUDING GRADUATE STUDENTS, POSTDOCTORAL FELLOWS, AND JUNIOR AND SENIOR INVESTIGATORS, AS WELL AS CLINICIANS AND PHYSICIANS, AND SCIENTISTS FROM INDUSTRY AND PHARMACEUTICAL COMPANIES, FROM THE FIELDS OF RNA BIOLOGY AND CANCER. THE CONFERENCE PROGRAM WILL INCLUDE INVITED LECTURES, SHORT TALKS FROM TRAINEES, AND EDUCATIONAL/PROFESSIONAL SESSIONS, FEATURING LEADING SCIENTISTS WITH DISTINCT EXPERTISE YET SHARED INTEREST IN UNDERSTANDING THE ROLE OF RNA PROCESSING IN CANCER PATHOGENESIS AND DEVELOPING NOVEL CANCER THERAPEUTICS THAT ENCOMPASS A VARIETY OF BACKGROUNDS, EXPERTISE, AND EXPERIENCE. OUR SPECIFIC AIMS ARE TO (1) ORGANIZE AN INTERDISCIPLINARY CONFERENCE ON RNA PROCESSING AND CANCER; (2) PROMOTE INTERACTIONS TO FOSTER COLLABORATIVE RESEARCH AND CAREER ADVANCEMENT; (3) FOSTER THE RECRUITMENT AND DEVELOPMENT OF JUNIOR INVESTIGATORS TO THE FIELD OF RNA BIOLOGY AND CANCER; AND (4) ACCELERATE TRANSLATION OF FUNDAMENTAL ADVANCES INTO NOVEL CLINICAL CANCER THERAPEUTICS. THE PROPOSED CONFERENCE WILL CROSS-POLLINATE THE FIELDS OF RNA BIOLOGY AND CANCER BIOLOGY, SEED NEW COLLABORATIONS ACROSS DISCIPLINES, AND FACILITATE THE NEXT GENERATION OF SCIENTISTS TO IMPLEMENT NOVEL STRATEGIES TOWARDS TARGETING RNA PROCESSING IN ONCOLOGY.

HEMATOLOGIC MALIGNANCIES - THE FASEB SCIENTIFIC RESEARCH CONFERENCE ON HEMATOLOGIC MALIGNANCIES PLAYS A KEY ROLE IN THE PROFESSIONAL AND CAREER DEVELOPMENT OF THE NEXT GENERATION OF LEADERS IN OUR FIELD. SINCE ITS INCEPTION IN 1995, THIS MEETING HAS HAD A STRONG TRADITION OF EXCEPTIONAL SCIENTIFIC PROGRAMMING, ABUNDANT OPPORTUNITIES FOR NETWORKING, AND HIGH-QUALITY CAREER DEVELOPMENT ACTIVITIES FOR OUR TRAINEES. A CRITICAL FEATURE OF THIS MEETING IS THE PRESENTATION OF HIGH-IMPACT UNPUBLISHED WORK IN A SETTING THAT PROMOTES DISCUSSION AND SPARKS COLLABORATION. THE PROGRAM REFLECTS THE FULL BREADTH OF RESEARCH IN THE FIELD, SPANNING STEM AND PROGENITOR DYSREGULATION, PREMALIGNANT HEMATOPOIESIS, MOLECULAR PATHOGENESIS, IMMUNE AND MICROENVIRONMENTAL REGULATION, AND THERAPEUTICS. THE WORK OF EARLY CAREER SCIENTISTS IS SHOWCASED THROUGHOUT THE MEETING THROUGH LIGHTNING TALKS, POSTER SESSIONS, AND SHORT TALKS SELECTED FROM THE ABSTRACTS. THIS MEETING OFFERS FORMAL OPPORTUNITIES FOR MENTORSHIP THROUGH INTERACTIVE PANEL DISCUSSIONS, MEET THE EXPERTS’ SESSIONS, AND NUMEROUS INFORMAL OPPORTUNITIES OVER SHARED MEALS AND ACTIVITIES. THE AIMS OF THIS PROPOSAL ARE TO (1) DEVELOP A CONFERENCE PROGRAM THAT HIGHLIGHTS THE MOST INNOVATIVE AND IMPACTFUL SCIENCE IN HEMATOLOGIC MALIGNANCIES, (2) TO CATALYZE SCIENTIFIC INTERACTIONS AND EXCHANGE OF IDEAS DURING AND BETWEEN SCIENTIFIC SESSIONS, AND (3) TO PROVIDE EARLY CAREER SCIENTISTS WITH OPPORTUNITIES TO PRESENT AND DISCUSS THEIR RESEARCH, NETWORK, AND FOSTER THEIR CAREER DEVELOPMENT. THE SOLE BUDGETARY REQUEST IN THIS R13 APPLICATION IS FOR 50% SUPPORT OF THE REGISTRATION AND HOUSING COSTS FOR GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS WHO WILL PRESENT ORAL OR POSTER PRESENTATIONS AT THIS CONFERENCE. FUNDING OF THIS APPLICATION WILL ENSURE THAT EARLY CAREER SCIENTISTS, WHO PLAY A KEY ROLE IN ITS VIBRANCY, ARE ABLE TO ATTEND.

REVERSIBLE BIOLOGICAL ACETYLATION IN HEALTH AND DISEASE - PROGRAM SUMMARY WE SEEK FUNDING FOR THE CONFERENCE "REVERSIBLE BIOLOGICAL ACETYLATION IN HEALTH AND DISEASES" UNDER THE AUSPICES OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB). THE 2024 CONFERENCE WILL BE THE 9TH MEETING OF THIS HIGHLY VALUED BIENNIAL CONFERENCE. THIS UNIQUE FORUM ATTRACTS SCIENTISTS WITH DIVERSE EXPERTISE IN BIOCHEMISTRY, STRUCTURAL BIOLOGY, CELL AND MOLECULAR BIOLOGY, DEVELOPMENTAL BIOLOGY, TRANSLATIONAL AND CLINICAL RESEARCH. WE AIM TO SHOWCASE THE LATEST CONCEPTUAL INSIGHTS AND TECHNICAL ADVANCES IN THE FIELD. THIS MEETING IS PARTICULARLY TIMELY BECAUSE OF EXCITING NEW FUNDAMENTAL DISCOVERIES IN THE LINKAGE OF ACETYLATION, METABOLISM, 3D CHROMATIN AND CANCER. FURTHERMORE, NOVEL SMALL MOLECULAR INHIBITORS ARE BEING DEVELOPED TO EFFECTIVELY BLOCK ONCOGENIC LYSINE ACETYLTRANSFERASES OR LYSINE DEACETYLASES. A PROVISIONAL CUTTING-EDGE PROGRAM PROVIDES A BALANCED SURVEY OF GROUNDBREAKING BASIC AND TRANSLATIONAL RESEARCH. MAJOR TOPICS INCLUDE: 1) WRITERS OF PROTEIN ACETYLATION; 2) READERS OF PROTEIN ACETYLATION; 3) ERASERS OF PROTEIN ACETYLATION; 4) 3D CHROMATIN ORGANIZATION; 5) METABOLIC REGULATION OF REVERSIBLE ACETYLATION; 6) BIOLOGICAL ACETYLATION IN CANCER; 7) BIOLOGICAL ACETYLATION IN DEVELOPMENT AND AGING; 8) ‘OMICS’ IN ACETYLATION; AND 9) CHEMICAL BIOLOGY AND DRUG DEVELOPMENT. THE FASEB MEETING TRADITIONALLY BRINGS ALL PARTICIPANTS IN A SINGLE CONFERENCE VENUE FOR UNOPPOSED SESSIONS. THE FORMAT INCLUDES PLENARY AND POSTER SESSIONS, WITH THE FORMER COVERING STATE-OF-THE-ART TOPICS BY LEADERS IN THE FIELD AND CUTTING-EDGE AND TIMELY ORAL PRESENTATIONS SELECTED FROM SUBMITTED POSTER ABSTRACTS FROM JUNIOR COLLEAGUES, PARTICULARLY PRE- AND POST-DOCTORAL TRAINEES. THIS ENSURES ACTIVE ENGAGEMENT OF JUNIOR PARTICIPANTS IN THE CONFERENCE AND STIMULATES ATTENDANCE AT POSTER SESSIONS. MOREOVER, THERE WILL BE A ‘MEET THE SPEAKER’ PERIOD FOLLOWING EACH PLENARY SESSION. TWO INTERACTIVE WORKSHOPS ARE PLANNED, ONE ON DIVERSITY NETWORKING, AND ANOTHER ON CAREER DEVELOPMENT FOR EARLY INVESTIGATORS. BOTH WORKSHOPS OFFER PARTICIPANTS THE OPPORTUNITY TO INFORMALLY SHARE CHALLENGES AND SOLUTIONS THAT THEY ENCOUNTER AT THE WORKPLACE AND TO PROMOTE AWARENESS OF THE DIVERSITY OF PEOPLES’ SITUATIONS, ALLYSHIP, NETWORKING AND MENTORSHIP. THE PRIMARY OBJECTIVE OF THE CONFERENCE IS TO BRING TOGETHER TOP BASIC SCIENTISTS, AND CLINICIAN INVESTIGATORS TO FOSTER INTERDISCIPLINARY COLLABORATIONS. A SECOND OBJECTIVE IS TO HELP DEVELOPMENT OF A NEW GENERATION OF SCIENTISTS INVESTIGATING MOLECULAR MECHANISMS INVOLVING KATS AND KDACS. THE ORGANIZERS WILL MAKE A CONCERTED EFFORT TO DESIGN A MEETING THAT ENGAGES AND SERVES OUR PRE- AND POSTDOCTORAL TRAINEES, EARLY-STAGE INDEPENDENT INVESTIGATORS AND SCIENTISTS FROM UNDER-REPRESENTED GROUPS. WE PROVIDE TRAVEL AWARDS AND BEST- POSTER AWARDS AS WELL AS PLENARY TALK OPPORTUNITIES FOR ACCOMPLISHED EARLY INVESTIGATORS AND INVESTIGATORS FROM UNDER-REPRESENTED COMMUNITIES TO ENHANCE THEIR INTERNATIONAL VISIBILITY AND ALLOW THEM TO ENJOY EXTENDED ACCESS TO WORLD-CLASS FACULTY AS THEY PONDER THEIR CAREER OPTIONS.

GENETIC RECOMBINATION & GENOME REARRANGEMENTS

FASEB SRC ON SKELETAL MUSCLE SATELLITE CELLS AND REGENERATION

FASEB SRC ON SIGNAL TRANSDUCTION IN THE IMMUNE SYSTEM

FASEB SUMMER RESEARCH CONFERENCES ON VIRUS STRUCTURE AND ASSEMBLY