University Research Foundation Inc

FOR 30 YEARS SAN JOSE STATE UNIVERSITY (SJSU) HAS PARTNERED WITH NASA AMES RESEARCH CENTER (ARC) ON COLLABORATIVE HUMAN SYSTEMS INTEGRATION RESEARCH (HSIR) THAT HAS MADE AIR AND SPACE TRAVEL MORE SAFE EFFICIENT AND RELIABLE. WE NOW PROPOSE A FIVE-YEAR RESEARCH PLAN TO BUILD UPON OUR COLLABORATIVE WORK IN THE HUMAN SYSTEMS INTEGRATION DIVISION (CODE TH) OTHER ARC DIVISIONS AND THE US MILITARY UNDER COOPERATIVE AGREEMENT NNX12AB08A. THE RESEARCH WE PROPOSE FULFILLS THE TECHNICAL AREAS PREVIOUSLY IDENTIFIED IN NASA SOLICITATION NNA11364623A THAT REMAIN RELEVANT TO THE MISSION AND STRATEGIC GOALS OF NASA AND OTHER GOVERNMENTAL ORGANIZATIONS (E.G. FAA US ARMY). THESE AREAS ARE: (1) HUMAN-AUTOMATION INTERACTION (2) HUMAN-COMPUTER INTERACTION AND (3) INDIVIDUAL- AND TEAM-PERFORMANCE FACTORS. THIS PROPOSAL WILL ALSO EXPAND UPON PREVIOUS RESEARCH BY INCORPORATING NEW EMPHASES THAT HAVE EMERGED SINCE OUR LAST PROPOSAL. THIS PROPOSAL ENCOMPASSES THE EXISTING SJSU/ARC LABORATORY ORGANIZATION AND TECHNICAL COMPETENCIES BASED ON OUR KNOWLEDGE OF NASA S PROCESSES ACQUIRED DURING OUR LONG PARTNERSHIP. WE ANTICIPATE SIGNIFICANT BENEFITS FOR NASA FROM MAINTAINING THAT PARTNERSHIP INCLUDING: (1) AN EXISTING STRONG RESEARCH AND MANAGEMENT INFRASTRUCTURE THAT WILL REMAIN ON-SITE THROUGHOUT THE AWARD PERIOD PROVIDING TIMELY AGILE AND ADAPTIVE RESPONSES TO NASAS NEEDS AND PRIORITIES; (2) LONG-TERM CONTINUITY FOR RESEARCH ACTIVITIES; (3) SHARED GOALS AND SHARED INSTITUTIONAL KNOWLEDGE; (4) KNOWN AND RESPECTED PERSONNEL WHO HAVE ESTABLISHED PRODUCTIVE WORKING RELATIONSHIPS WITH NASA SCIENTISTS AND MANAGEMENT; (5) ACADEMIC STUDENT AND PUBLIC OUTREACH PROGRAMS CREATED TO ENHANCE NASA PROJECTS DEVELOP RELEVANT WORKFORCE SKILLS AND MEET NASA S MISSION AND STRATEGIC GOALS; (6) AN EXPERIENCED MANAGEMENT TEAM WITH A STRONG FOCUS ON SUSTAINED COLLABORATION; (7) A SUPPORTIVE AND RESPONSIVE ORGANIZATION IN THE SAN JOSE STATE UNIVERSITY RESEARCH FOUNDATION (SJSURF); (8) PROVEN SUCCESSFUL PROJECT MODELS; AND (9) RESOURCE EFFICIENCIES THROUGH AVOIDANCE OF A TIME-CONSUMING AND COSTLY TRANSITION TO ANOTHER RESEARCH ORGANIZATION.

ANTICIPATED DRAMATIC INCREASES IN AIR TRAFFIC HAVE FUELED THE PLANNED CONVERSION TO THE NEXT GENERATION AIR TRANSPORTATION SYSTEM, WHICH REINVENTS AI

HUMAN SYSTEMS INTEGRATION: COLLABORATIVE HUMAN FACTORS RESEARCH TO IMPROVE THE SAFETY EFFICIENCY AND RELIABILITY OF NASAS AERONAUTICS AND SPACE MISSIONS: PHASE 2

BEING A FIVE YEAR COOPERATIVE AGREEMENT WITH A TECOF $24,000,000 AND INITIAL OBLIGATION OF $500,000

INVESTING IN INNOVATION - SCALE UP

THE SCIENCE OF DECISION MAKING: CONNECTING PEOPLE AND POLICY

TO PROVIDE SUPPORT FOR "FAMILY PLANNING AND REPRODUCTIVE HEALTH METHODS TO ADDRESS UNMET NEEDS"

PROTOTYPE STUDY OF A NEW CENTRAL DRIFT CHAMBER FOR CLEO II & INVESTIGATION OF THE T PARADOX USING CLEO II OUTSTANDING JUNIOR INVESTIGATOR PROGRAM.

THERAPEUTICS TARGETING FILOVIRAL INTERFERON-ANTAGONIST AND REPLICATION FUNCTIONS

CROSS-INSTITUTIONAL COLLABORATION AND REIMAGINING TOWARD EQUITY, ACCESS, AND TEACHER EFFECTIVENESS: EXPANDING AND SUSTAINING PROJECT CREATE

GEAR-UP

FROM QUARKS TO NUCLEI

FY 2009 TEACHER QUALITY PARTNERSHIPS GRANTS

SCIENCE ROOTS: GROWING STUDENT FUTURES THROUGH GENAI ENHANCED PROJECT-BASED LEARNING USING GREEN NINJA

NATIONAL CENTER FOR SPECIAL RESEARCH (NCSER)

NEW COE CA "DOD CENTER OF EXCELLENCE IN ADVANCED COMPUTING AND SOFTWARE (COE-ACS)"

EDUCATION RESEARCH AND DEVELOPMENT CENTERS

THIS UNSOLICITED COOPERATIVE AGREEMENT PROPOSAL SEEKS FUNDING FOR THREE YEARS TO CONDUCT COLLABORATIVE RESEARCH BETWEEN THE U.S. ARMY AVIATION DEVELOPMENT DIRECTORATE AT NASA AMES RESEARCH CENTER AND THE DEPARTMENT OF PSYCHOLOGY AT SAN JOSE ...

STRENGTHENING THE UNIVERSITY-DISTRICT-COMMUNITY PARTNERSHIP: COMPASSION, REFLECTION AND EQUITY FOR ATLANTA TEACHER EFFECTIVENESS (CREATE)

MODELING AND SIMULATION OF HUMAN PERFORMANCETHE PRESENT PROPOSAL REQUESTS AN 18-MONTH CONTINUATION

CENTER FOR BEHAVIORAL NEUROSCIENCE

MULTIVARIATE METHODS FOR IDENTIFYING MULTI-TASK/MULTIMODAL BRAIN IMAGING BIOMARKE

MECHANISMS OF EVASION OF THE INNATE AND ADAPTIVE IMMUNE RESPONSES TO FILOVIRUSES

FY 2009 TEACHER QUALITY PARTNERSHIPS GRANTS

FIRST IN THE WORLD - VALIDATION

STARVE AND KILL: ENGINEERED ANTIGENS TARGETING NUTRIENT ACQUISITION PATHWAYS ESSENTIAL FOR GONOCOCCAL INFECTION AND DISEASE

THE PRESENT UNSOLICITED PROPOSAL REQUESTS FUNDING OF A THREE-YEAR COOPERATIVE AGREEMENT BETWEEN THE ARMY AEROFLIGHTDYNAMICS DIRECTORATE (AFDD) AT THE

UNIVERSITY TRANSPORTATION CENTERS

ADVANCED GAS TURBINE SYSTEMS RESEARCH - HIGH EFFICIENCY ENGINES AND TURBINES (AGTSR-HEET)

FUTURE VERTICAL LIFT: COLLABORATIVE RESEARCH ON FLIGHT CONTROL AUTONOMOUS ROTORCRAFT AND HUMAN-SYSTEMS INTERFACE DESIGN: PHASE 2

THE PRIMARY PURPOSE OF THE PROPOSED PROGRAM IS TO TRANSFER FUNDS TO ACCOMPLISH A PUBLIC PURPOSE OF SUPPORT OR STIMULATION OF THE HIV PREVENTION PRODUCTS TARGETED FOR ADOLESCENT GIRLS AND YOUNG WOMEN IN LOW AND MIDDLE INCOME COUNTRIES.

MATHEMATICAL BIOSCIENCES INSTITUTE

NURTURES

THE OHIO STATE UNIVERSITY CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE (UL1)

CREW FACTORS AND TEAM PERFORMANCE PHASE IITHE PRESENT PROPOSAL REQUEST THE CONTINUATION OF FUNDING

CREATE (COLLABORATION AND REFLECTION TO ENHANCE ATLANTA TEACHER EFFECTIVENESS)

TAS::57 3600::TAS (MURI 09) FUNDAMENTAL MECHANISMS, PREDICTIVE MODELING, AND NOVEL AEROSPACE APPLICATIONS OF PLASMA ASSISTED COMBUSTION

CENTER OF EXCELLENCE: ENVIRONMENTAL HEALTH DISPARITIES CORE

IMPLEMENTATION GRANT: COMMUNITY-SOIL-AIR-WATER (CSAW): A MODEL COMMUNITY-BASED LEARNING ECOSYSTEM TO TRANSFORM GEOSCIENCES -THE COMMUNITY-SOIL-AIR-WATER (CSAW) LEARNING ECOSYSTEM WILL INTEGRATE JUSTICE, EQUITY, DIVERSITY, AND INCLUSION INTO THE PRACTICES OF COLLABORATING WITH COMMUNITIES IN GEOSCIENCES RESEARCH. TO EXPAND CAPACITY AND ACCOUNTABILITY IN SOCIO-ENVIRONMENTAL RESEARCH COLLABORATIONS BETWEEN GEOSCIENTISTS AND COMMUNITY PARTNERS, CSAW WILL BRING TOGETHER THREE ACADEMIC PARTNERS (GEORGIA STATE UNIVERSITY, A PREDOMINANTLY BLACK INSTITUTION, SPELMAN COLLEGE, A HISTORICALLY BLACK COLLEGE, AND EMORY UNIVERSITY) WITH TWO COMMUNITY ORGANIZATIONS: THE WEST ATLANTA WATERSHED ALLIANCE AND ECO-ACTION. THIS PROJECT WILL ADDRESS THE QUESTION: HOW CAN GEOSCIENTISTS LEARN FROM, CONTRIBUTE TO, AND FIND SOLUTIONS WITH COMMUNITIES FACING FUNDAMENTAL PROBLEMS RELATED TO EARTH SYSTEMS? CSAW WILL EXAMINE HOW A LEARNING ECOSYSTEM MODEL CENTERED IN COMMUNITY-ENGAGED, PLACE-BASED RESEARCH CAN INCREASE: (1) RECRUITMENT, RETENTION, AND TRAINING OF DIVERSE GEOSCIENTISTS; AND (2) CAPACITY FOR AND ACCOUNTABILITY WITHIN COLLABORATION BETWEEN GEOSCIENTISTS AND COMMUNITIES ADDRESSING SOCIO-ENVIRONMENTAL PROBLEMS. COHORTS OF FACULTY AND COMMUNITY ORGANIZERS ALONG WITH 12 POST-BACCALAUREATE (POSTBAC) SCHOLARS AND 15 MASTER?S STUDENTS WILL BE TRAINED IN BUILDING OUTREACH AND RESEARCH PROJECTS WITH COMMUNITY PARTNERS USING A FRAMEWORK OF SHARED VALUES OF EQUITY, TRANSPARENCY, AND ACCOUNTABILITY. THESE PROJECTS WILL ADDRESS CRITICAL NEEDS IN PLACE-BASED EARTH SYSTEMS RESEARCH INCLUDING SOIL LEAD AND OTHER HEAVY METAL CONTAMINATION AND RADON EXPOSURE; AIR POLLUTION, CLIMATE CHANGE, AND HEAT MAPPING; AND WATER POLLUTION, URBAN FLOODING, AND GREEN STORMWATER INFRASTRUCTURE. THE OVERALL GOALS AND OBJECTIVES OF THE PROJECT ARE TO BUILD A BRIDGE: 1) BUILD AND FORMALIZE THE CSAW LEARNING ECOSYSTEM WITH ALL COHORT MEMBERS TO SOLVE SOCIO-ENVIRONMENTAL CHALLENGES; 2) RECRUIT DIVERSE COHORTS OF POSTBACS AND MASTER?S STUDENTS AND TRAIN THEM IN PROFESSIONAL DEVELOPMENT, COMMUNITY ENGAGEMENT, AND NETWORKING, WITH A FOCUS ON CENTERING JUSTICE, EQUITY, AND INCLUSION; 3) IMPLEMENT TRAINING, PROGRAMMING, AND PEDAGOGY PROTOCOLS TO RECRUIT, MENTOR, AND SUPPORT DIVERSE STUDENTS, COMMUNITY COLLABORATORS, AND FACULTY IN THE GEOSCIENCES; 4) DEVELOP AN ASSET-BASED MODEL OF COLLABORATION WITH COMMUNITY-DRIVEN RESEARCH TO INCLUDE FORMAL TRAINING, ACCOUNTABILITY, AND ASSESSMENT FOR ENGAGEMENT PRACTICES AND OUTCOMES; AND 5) GROW A NETWORK, MATERIALS, AND PROTOTYPE TO EXPAND THE CSAW LEARNING ECOSYSTEM MODEL TO OTHER COMMUNITIES, UNIVERSITIES, AND INSTITUTIONS. CSAW PARTNERSHIPS WILL ADVANCE A BROAD RANGE OF SCHOLARSHIP ON SOCIO-ENVIRONMENTAL PROBLEMS AND THEIR SOLUTIONS, AND ON BEST PRACTICES FOR GEOSCIENTISTS IN COMMUNITY ENGAGEMENT, ACCOUNTABILITY, AND CO-PRODUCTION. CSAW WILL PROVIDE A WELL-EVALUATED AND SUCCESSFUL MODEL TO ADOPT IN TRANSFORMATIVE GEOSCIENCES WORK ACROSS DISCIPLINES. THROUGH BROADENING PARTICIPATION OF UNDERREPRESENTED GROUPS AND BUILDING AND ENHANCING PARTNERSHIPS WITH COMMUNITY ADVOCACY GROUPS, THE CSAW LEARNING ECOSYSTEM WILL PROVIDE A PROTOTYPE TO PROMOTE GEOSCIENCE TRANSFORMATIONS AT OTHER INSTITUTIONS AND ACROSS DISCIPLINES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

COINSTAC: DECENTRALIZED, SCALABLE ANALYSIS OF LOOSELY COUPLED DATA

UNIVERSITY TRANSPORTATION CENTER

AMPK AS A REDOX SENSOR AND MODULATOR

TRANSITION TO TEACHING PROGRAM -- NATIONAL

(MURI 06) INTEGRATED FUSION, PERFORMANCE PREDICTION, AND SENSOR MANAGEMENT FOR AUTOMATIC TARGET EXPLOITATION

INNOVATIONS IN DEVELOPING RESIDENT EDUCATORS AND MENTORS

DEVELOPMENT OF THE OHIO STATE UNIVERSITY LABORATORY FOR ADVANCED LASER-TARGET INTERACTIONS (LALTI) FOR APPLICATION IN HIGH ENERGY DENSITY SCIENCE & D

TAS::57 3600::TAS "(MURI FY10) CRYOGENIC PELTIER COOLING"

MINING THE GENOMEWIDE SCAN: GENETIC PROFILES OF STRUCTURAL LOSS IN SCHIZOPHRENIA

NOVEL INFLUENZA A NANOVACCINES FOR BROAD CROSS PROTECTION

SAN JOSE STATE UNIVERSITY UNDERGRADUATE MBRS RISE PROGRAM

NEISSERIA GONORRHOEAE METAL TRANSPORTERS THAT SUBVERT NUTRITIONAL IMMUNITY

INTERROGATING STRESS-RELIEVING NEURAL CIRCUITS TO ALLEVIATE CARDIOVASCULAR DISEASE

THE PRESENT UNSOLICITED PROPOSAL REQUESTS FUNDING OF A THREE-YEAR COOPERATIVE AGREEMENT BETWEEN THE ARMY AEROFLIGHTDYNAMICS DIRECTORATE (AFDD) AT THE

IDENTIFICATION AND PRE-CLINICAL EVALUATION OF MEASLES VIRUS INHIBITORS

THE PRESENT PROPOSAL REQUESTS FUNDING OF A THREE-YEAR COOPERATIVE AGREEMENT BETWEEN THE ARMY AEROFLI

SHIP OPERATIONS R/V POINT SUR 2012 - 2016

NSEC: CENTER FOR AFFORDABLE NANOENGINEERING OF POLYMER BIOMEDICAL DEVICES (CANPBD)

SHIP OPERATIONS

PROJECT ENGINEERING SUCCESS: INCREASING HISPANIC STUDENT SUCCESS IN ENGINEERING AT SAN JOSE STATE UNIVERSITY, SAN JOSE CITY COLLEGE AND GAVILAN COLLEGE

EXPERIMENTAL NUCLEAR PHYSICS

PATHOPHYSIOLOGY OF TLR5KO COLITIS

CREST CENTER FOR DYNAMIC MULTISCALE AND MULTIMODAL BRAIN MAPPING OVER THE LIFESPAN [D-MAP]

TAS::89 0328::TAS RECOVERY - NEW AWARD THE OHIO STATE UNIVERSITY. I-SMART: INTEGRATED CURRICULUM FOR SMART POWER ENGINEERING. AWARD IS TO FACILITAT

DEVELOPMENT OF A BROAD-SPECTRUM INHIBITOR AGAINST SEASONAL AND HIGHLY-PATHOGENIC INFLUENZA VIRUSES

REUTTER: OHIO SEA GRANT COLLEGE PROGRAM FEBRUARY 2010-JANUARY 2012

AMP-ACTIVATED KINASE IN DIABETIC COMPLICATIONS

VIRGINIA SPACE GRANT CONSORTIUM

INCREMENTAL FUNDING

RECOVERY ACT GREEN JOBS

LEADERSHIP EDUCATION IN NEURODEVELOPMENTAL AND RELATED DISORDERS TRAINING PROGRAM

DECONSTRUCTING INFLAMMATION AND ALTERED MICROBIOTA IN METABOLIC SYNDROME

HUMAN-SYSTEM INEGRATION TECHNOLOGIES

EXPLORING THE MILLIARCSECOND FRONTIER: OPEN ACCESS TO THE RENEWED CHARA ARRAY

NEURONS EXPRESSING ANGIOTENSIN TYPE 2 RECEPTORS IN THE NTS AS AN ACCESS POINT FOR CARDIOVASCULAR CONTROL.

ADVANCING INNOVATIVE PARTNERSHIPS AND PATHWAYS TO ADDRESS MENTAL HEALTH WORKFORCE SHORTAGES IN GEORGIA SCHOOLS

MARC U STAR AT SAN JOSE STATE UNIVERSITY

SAN JOSE STATE UNIVERSITY PROPOSES A MULTI-UNIVERSITY CONSORTIUM (C-STTAR) TO ESTABLISH A CLIMATE CHANGE AND EXTREMEEVENTS TRAINING AND RESEARCH (CCEETR) PROGRAM. THE PROGRAM OBJECTIVE IS TO CONDUCT, RESEARCH, EDUCATION, ANDTECHNOLOGY TRANSFER ACTIVITIES TO IMPROVE THE RAIL NETWORK S SAFETY AND RESILIENCE AGAINST EXTREME EVENTS, INCLUDING CLIMATECHANGE. THE APPLICANT WILL FOCUS ON FIVE PROJECTS DIRECTED AT EDUCATING THE RAILROAD COMMUNITY AND EVALUATING ANDDEMONSTRATING TECHNOLOGIES AND APPROACHES THAT SHOW PROMISE FOR MITIGATING THE CONSEQUENCES OF EXTREME EVENTS ONRAILROAD OPERATIONS: APPLICATION OF EMERGING TECHNOLOGIES TO CREATE EVALUATION AND SIMULATION SCENARIOS FOR RAILROAD PERSONNELTRAINING CREATION AND DELIVERY OF TRAINING PROGRAMS THAT CAN BE USED BY FREIGHT AND PASSENGER RAILROADS TO ENHANCE THEIRABILITY TO DEVELOP RESPONSE PROGRAMS TO ENHANCE RESILIENCY. DEVELOPMENT OF PREDICTIVE ASSESSMENT TOOLS TO SUPPORTDETECTION, ALERT, AND WARNING SYSTEMS PLANNING, OPERATIONS, RESPONSE, AND RECOVERY FROM EMERGENCIES AND DISRUPTIVE EVENTS ENHANCE TECHNOLOGY TRANSFER, CAREER PATHWAYS, ECONOMIC AND WORKFORCE DEVELOPMENT FOR MINORITY, SMALL BUSINESSES, ANDUNDERSERVED COMMUNITIES EVALUATION AND DEMONSTRATION OF SENSORS ON MOBILE AND FIXED PLATFORMS TO IDENTIFY RISKS FOR THENORTH AMERICAN RAIL NETWORK

PIRE: CENTENNIAL GENETIC AND SPECIES TRANSFORMATIONS IN THE EPICENTER OF MARINE BIODIVERSITY

WESTERN KENTUCKY UNIVERSITY RESEARCH FOUNDATION, INC.

THE MOTIVATION FOR THE ESTABLISHMENT OF A NASA MIRO CENTER FOR APPLIED ATMOSPHERIC RESEARCH AND EDUCATION (CAARE) AT SAN JOSE STATE UNIVERSITY (SJSU)

EXPERIMENTAL AND COMPUTATIONAL TOOLS FOR THE DIGITAL REPRESENTATION AND PREDICTION OF MICROSTRUCTURE AND IT'S INCORPORATION IN THE DESIGNER'S KNOWLED

SAN JOSE GEAR UP COMMUNITY ACHIEVEMENT PROJECT

LEADERSHIP EDUCATION IN NEURODEVELOPMENTAL AND RELATED DISORDERS TRAINING PROGRAM

NOVEL NONLINEAR OPTICAL PROCESSES IN ACTIVE, RANDOM AND NANOSTRUCTURED SYSTEMS

"SCIENTIFIC CHALLENGES ASSOCIATED WITH MULTI-MATERIALS SYSTEM WITH ADAPTIVE MICROSTRUCTURES FOR AEROSPACE APPLICATIONS"

TEACHER QUALITY ENHANCEMENT GRANTS FOR STATE AND PARTNERSHIPS - PARTNERSHIP GRANTS

NEUROCOGNITIVE BASES OF TREATMENT RESISTANCE IN DEVELOPMENTAL DYSLEXIA

REACTIVE NITROGEN AND ACCELERATED ATHEROSCLEROSIS IN TYPE I DIABETES

VIRGINIA SPACE GRANT CONSORTIUM FY2020-2024

DISABILITY AND REHABILITATION RESEARCH PROJECTS

INFLUENZA VACCINES INDUCING BROADLY CROSS PROTECTIVE IMMUNITY

ADDRESSING SOCIAL DETERMINANTS OF HEALTH IN THE MOST DIVERSE SQUARE MILE IN AMERICA

STRUCTURE-BASED DESIGN OF CORONAVIRUS SUBUNIT VACCINES

PROJECT 6 - THE EXPRESSION OF HUMAN CATALYTIC PROTEINS IN MICRO ALGAE ON A COMMERCIAL SCALE

RATIONAL DESIGN AND EVALUATION OF NOVEL MRNA VACCINES AGAINST MERS-COV

BIOBEHAVIORAL FOUNDATIONS AND DEVELOPMENT OF COGNITIVE COMPETENCE

FY 2009 TEACHER QUALITY PARTNERSHIPS GRANTS

"A THEORETICALLY DRIVEN INVESTIGATION OF THE EFFICACY OF AN IMMERSIVE INTERACTIVE AVATAR"

ADVANCE INSTITUTIONAL TRANSFORMATION AWARD: COMPREHENSIVE EQUITY AT OHIO STATE (CEOS)

UNIVERSITY TRANSPORTATION CENTERS

CYBERCORPS SCHOLARSHIP FOR SERVICE: PREPARING FUTURE CYBERSECURITY LEADERS THROUGH APPLIED LEARNING EXPERIENCES

ADVANCING RURAL COMPUTER SCIENCE (ARCS)

NURSE EDUCATION, PRACTICE, QUALITY AND RETENTION

ENABLING MILLIARCSECOND ASTROPHYSICS: OPEN ACCESS FOR THE CHARA ARRAY

NOVEL NANOBODIES TO PREVENT AND TREAT SARS-COV-2 AND OTHER PATHOGENIC HUMAN CORONAVIRUSES

SNAP NUTRITION OBESITY GRANT

MULTIVALENT NANOCLUSTER UNIVERSAL INFLUENZA VACCINE GIVEN BY MICRONEEDLE PATCH

ENHANCING SAFETY AND WELL-BEING OF CHILDREN OF ADULT DRUG COURT PARTICIPANTS

COMMUNICATING ABOUT NICOTINE AND DIFFERENTIAL RISKS OF TOBACCO PRODUCTS

VLP VACCINE TECHNOLOGY

DATA DRIVEN DYNAMIC ACTIVITY/CONNECTIVITY METHODS FOR EARLY DETECTION OF ALZHEIMER?S - PROJECT SUMMARY/ABSTRACT THE DEVELOPMENT OF BIOMARKERS FOR IDENTIFYING PRECLINICAL OR PRODROMAL ALZHEIMER’S DISORDER ARE OF GREAT IN- TEREST. WHILE SOME INITIAL RESULTS BASED ON RESTING FMRI HAVE BEEN PRESENTED, ACCURACY, ROBUSTNESS, AND RELIA- BILITY ARE STILL RELATIVELY LOW. ONE HIGHLY PROMISING DIRECTION IS THE DEVELOPMENT OF DYNAMIC FUNCTIONAL ACTIVITY AND FUNCTIONAL CONNECTIVITY APPROACHES. THESE APPROACHES HAVE BEEN SHOWN TO BE ESPECIALLY PROMISING MOST LIKELY DUE TO THE HIGHLY DYNAMIC NATURE OF THE BRAIN AND THE UNCONSTRAINED NATURE OF RESTING FMRI. CURRENTLY, THERE ARE NO METHODS THAT CAN PROVIDE A FULL CHARACTERIZATION OF TEMPORAL, SPATIAL, AND SPATIO-TEMPORAL DYNAMICS NOR CAN MOST EXISTING APPROACHES CHARACTERIZE HETEROGENOUS SUBGROUPS OR COMPLEX MULTISCALE RELATIONSHIPS. WE WILL DEVELOP NEW METHODS THAT CAN EFFECTIVELY CAPTURE DYNAMIC CONNECTIVITY AND PROVIDE SUMMARY METRICS WITH A FOCUS ON INDIVIDUALIZED PREDICTION OF ALZHEIMER’S DISEASE WELL PRIOR TO THE ONSET OF THE ILLNESS. WE PROPOSE A NOVEL FAMILY OF MODELS THAT BUILDS ON THE WELL-STRUCTURED FRAMEWORK OF JOINT BLIND SOURCE SEPARATION TO CAPTURE A MORE COMPLETE CHARACTERIZATION OF (POTENTIALLY NONLINEAR) SPATIO-TEMPORAL DYNAMICS. OUR MODELS WILL ALSO PRO- DUCE A RICH SET OF METRICS TO CHARACTERIZE THE AVAILABLE DYNAMICS AND ENABLE IN DEPTH COMPARISON WITH CURRENTLY AVAILABLE MODELS. WE SHOW EVIDENCE THAT SUCH MEASURES ARE LIKELY TO BE CONSIDERABLY MORE SENSITIVE AND MORE ACCURATE IN CLASSIFYING INDIVIDUALS. WE WILL EXTENSIVELY VALIDATE OUR APPROACHES IN A VARIETY OF WAYS INCLUDING SIMULATIONS, CONCURRENT EEG/FMRI DATA, AND EVALUATION ON A LARGE NORMATIVE DATA SET. WE WILL APPLY THE DEVEL- OPED METHODS TO SEVERAL LARGE DATASETS INCLUDING A LARGE LONGITUDINAL SAMPLE OF INDIVIDUALS WHO HAVE BEEN SCANNED AT EMORY UNIVERSITY WITH RESTING FMRI WHO ALSO HAVE CSF AMYLOID AND TAU PET MEASURES. WE WILL USE THE DEVELOPED MARKERS TO PREDICT COGNITIVE DECLINE, AMYLOID, AND TAU LEVELS IN THESE DATA AND INCLUDE BOTH A DISCOVERY DATA SET AS WELL AS AN INDEPENDENT REPLICATION DATA SET. SUCCESSFUL COMPLETION OF OUR AIMS WILL BE AN IMPORTANT FIRST STEP TOWARDS PROVIDING AN OPPORTUNITY TO DEVELOP AND EVALUATE INTERVENTIONS EARLY ENOUGH TO HAVE A POSITIVE IMPACT ON LONG-TERM PROGNOSIS. WE WILL PROVIDE OPEN SOURCE TOOLS AND RELEASE DATA THROUGHOUT THE DURATION OF THE PROJECT VIA GITHUB, A WEB PORTAL AND THE NITRC REPOSITORY, HENCE ENABLING OTHER INVESTIGATORS TO COMPARE THEIR OWN METHODS WITH OUR OWN AS WELL AS TO APPLY THEM TO A LARGE VARIETY OF BRAIN DISORDERS. OUR TOOLS ALSO HAVE WIDE APPLICATION TO THE STUDY OF THE HEALTHY BRAIN AS WELL AS MANY OTHER DISEASES. 37

RESEARCH IN HEAVY ION NUCLEAR REACTIONS

MALE/FEMALE DIFFERENCES IN PSYCHOSIS AND MOOD DISORDERS:DYNAMIC IMAGING-GENOMIC MODELS FOR CHARACTERIZING AND PREDICTING PSYCHOSIS AND MOOD D

MOBY LWN TIME-SERIES UNCERTAINTY REDUCTION AND SYSTEM ENHANCEMENTS FOR IMPROVED VICARIOUS CALIBRATION ACROSS MULTIPLE AGENCY OCEAN COLOR SATELLITE MI

POLYMERASE INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS

MEANINGFUL ENGAGEMENT AND QUALITY OF LIFE AMONG ASSISTED LIVING RESIDENTS WITH DEMENTIA

ASSESSING THE INTENDED AND UNINTENDED CONSEQUENCES OF E-CIGARETTE TV ADVERTISING

VSGC ALIGNS WITH THE NATIONAL SPACE GRANT PROGRAM OBJECTIVES OF: (1) PROMOTING A STRONG STEM EDUCATION BASE FROM ELEMENTARY THROUGH SECONDARY LEVELS

FY 2009 TEACHER QUALITY PARTNERSHIPS GRANTS

CONTROLLING VSMC PROLIFERATION AND MIGRATION

EXAMINING CARBON MONOXIDE TO TREAT INFLAMMATORY CONDITIONS USING EXPERIMENTAL COLITIS MODELS

"(GAMECHANGER) -MULTIFUNCTIONAL DESIGN OF HYBRID COMPOSITES OF LOAD BEARING ANTENNAS" REVISED 23 APR 07

HIGH ANGULAR RESOLUTION COMMUNITY SCIENCE AT THE CHARA ARRAY -THE CENTER FOR HIGH ANGULAR RESOLUTION ASTRONOMY (CHARA) ARRAY IS THE NATION?S PREMIER FACILITY FOR LONG BASELINE OPTICAL INTERFEROMETRY. WITH THE NUMBER AND SIZE OF ITS TELESCOPES, THE LENGTH OF ITS BASELINES, AND THE RANGE OF WAVELENGTHS COVERED BY ITS BEAM COMBINERS, THE CHARA ARRAY IS A UNIQUELY POWERFUL FACILITY FOR MILLIARCSECOND IMAGING. WITH ADAPTIVE OPTICS AND FOUR NEW BEAM COMBINERS, THE ARRAY IS REACHING DEEPER THAN EVER. SINCE 2004 CHARA RESULTS HAVE APPEARED IN SOME 245 PAPERS IN THE REFEREED LITERATURE. THIS INCLUDES OBSERVATIONS OBTAINED DURING THE HIGH-DEMAND OPEN ACCESS PROGRAM SUPPORTED BY NSF FOR SOME YEARS, AND OPERATED IN COLLABORATION WITH NSF?S NATIONAL OPTICAL-INFRARED RESEARCH LABORATORY. THIS AWARD EXTENDS THAT PROGRAM FOR ANOTHER THREE YEARS, AND INCLUDES A NEW SNAPSHOT IMAGING MODE. THE TEAM ALSO PLANS TO OFFER USER SUPPORT, COMMUNITY WORKSHOPS, AND AN ACCESSIBLE DATA ARCHIVE. CHARA WILL FOSTER COLLABORATIONS WITH AMATEUR ASTRONOMERS THROUGH THE AMERICAN ASSOCIATION OF VARIABLE STAR OBSERVERS. CHARA TRAINS GRADUATE STUDENTS TO BUILD AND USE PRECISION TECHNOLOGY. THE CHARA ARRAY ACHIEVES SUB-MILLIARCSECOND RESOLUTION AT VISIBLE AND NEAR-INFRARED WAVELENGTHS, AND CAN BE USED TO RESOLVE THE RADII OF STARS ALL ALONG THE MAIN SEQUENCE AND AT DIFFERENT STAGES AS STARS EVOLVE OFF THE MAIN SEQUENCE. THE ARRAY REVEALS THE IMPACT OF LIMB- AND GRAVITY-DARKENING, THE SPATIAL DISTRIBUTION AND SIZE OF STAR-SPOTS AND ACTIVITY IN CONVECTION ZONES, AND PROVIDES PHYSICAL PROPERTIES OF EXOPLANET HOST STARS. THE CHARA ARRAY RESOLVES BINARY STARS, MAPS ORBITS, AND PROBES INTERACTING SYSTEMS. EXTRAGALACTIC OBSERVATIONS PROBE THE STRUCTURE OF ACTIVE GALACTIC NUCLEI CORES TO SHOW HOW SUPERMASSIVE BLACK HOLES IMPACT ACCRETION AND TRIGGER OUTFLOWS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

WRITING IN ADULT SECONDARY EDUCATION CLASSES (W-ASE)

(SURI) SPACE DOMAIN AWARENESS IN A PHOTON-STARVED ENVIRONMENT (SDAPSE)

UNIVERSITY TRANSPORTATION CENTER - TRANSPORTATION SYSTEMS POLICY AND MANAGEMENT

COLLABORATIVE RESEARCH: IPY: POLENET-ANTARCTICA: INVESTIGATING LINKS BETWEEN GEODYNAMICS AND ICE SHEETS

FLEXIBLE MULTIVARIATE MODELS FOR LINKING MULTI-SCALE CONNECTOME AND GENOME DATA IN ALZHEIMER'S DISEASE AND RELATED DISORDERS

PHOTOPERIODIC CONTROL OF OBESITY

LIGHTWEIGHT INTERMETALLICS FOR HYDROGEN STORAGE

ADVANCED OPTICAL FIBERS FOR HIGH POWER FIBER LASERS

MISSION STATEMENT: THE VIRGINIA SPACE GRANT CONSORTIUM ACTS AS AN UMBRELLA ORGANIZATION COORDINATING AND DEVELOPING QUALITY AEROSPACE-RELATED HIGH

DEVELOPING INHIBITORS OF SEASONAL AND PANDEMIC INFLUENZA VIRUSES - SUMMARY INFLUENZA VIRUSES ARE A LEADING CAUSE OF HUMAN DISEASE DUE TO RESPIRATORY VIRAL INFECTION WORLDWIDE. IT IS THE OVERARCHING OBJECTIVE OF THIS PROJECT TO ADVANCE PRODRUG CONJUGATES OF 4’-FLUOROURIDINE (4’-FLU), A NOVEL PYRIMIDINE ANALOG WITH CONFIRMED BROAD ORAL EFFICACY AGAINST INFLUENZA VIRUSES, AND AT LEAST ONE NON-NUCLEOSIDE INHIBITOR OF THE INFLUENZA VIRUS POLYMERASE COMPLEX, TO THE STAGE OF FORMAL PRECLINICAL DEVELOPMENT AND ASSEMBLY OF AN INVESTIGATIONAL NEW DRUG-ENABLING PACKAGE. THE PROJECT DESIGN IS DRIVEN BY OUR UNDERLYING HYPOTHESIS THAT EFFECTIVE NEXT-GENERATION THERAPEUTICS FOR THE TREATMENT OF INFLUENZA MUST BE ORALLY AVAILABLE, DISPLAY A BROAD INDICATION SPECTRUM AGAINST INFLUENZA VIRUS ISOLATES OF HUMAN, AVIAN, AND SWINE LINEAGES, AND IDEALLY COVER BOTH INFLUENZA A (IAV) AND B (IBV) VIRUSES. THESE PRODUCT PROFILE DEMANDS ARE DERIVED FROM THE CLINICAL BURDEN IMPOSED BY THE DIVERSE SPECTRUM OF SEASONAL INFLUENZA VIRUSES, THE PANDEMIC POTENTIAL ARISING FROM SPILLOVER OF ZOONOTIC AVIAN VIRUSES INTO THE HUMAN POPULATION, AND CURRENT FDA RECOMMENDATIONS THAT RECOGNIZE OUTPATIENT ADULTS SUFFERING FROM SEASONAL INFLUENZA AS THE PRIMARY PATIENT POPULATION FOR INITIAL CLINICAL TESTING. THESE DEVELOPMENTAL OBJECTIVES ARE BEST MET WITH DIRECT ACTING THERAPEUTICS, SINCE HOST-TARGETED ANTIVIRAL THERAPIES, ALTHOUGH OFTEN TANTALIZINGLY BROAD IN INDICATION RANGE, ARE PRONE TO UNACCEPTABLE SIDE EFFECTS THAT ARE INCOMPATIBLE WITH THE PRIMARY PATIENT GROUP PURSUED. IN PREVIOUS WORK UNDERPINNING THIS PROGRAM, WE HAVE DEMONSTRATED BROAD-SPECTRUM ANTIVIRAL ACTIVITY OF 4’-FLU IN CULTURED CELLS AND ANIMAL INFECTION MODELS AGAINST A CLINICALLY SIGNIFICANT PANEL OF RNA VIRUSES. AGAINST THE INFLUENZA VIRUS INDICATION, 4’-FLU HAS CONFIRMED ORAL EFFICACY AGAINST SEASONAL, PANDEMIC, AND HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUSES IN RODENT AND NON-RODENT MODELS. THE COMPOUND TRIGGERS IMMEDIATE CHAIN TERMINATION OF THE INFLUENZA VIRUS RNA-DEPENDENT RNA POLYMERASE (RDRP) COMPLEX AND CARRIES A HIGH BARRIER TO VIRAL RESISTANCE. IN PREPARATION OF CLINICAL DEVELOPMENT, WE HAVE GENERATED PRODRUG CONJUGATES OF 4’-FLU TO OPTIMIZE DELIVERY ACROSS THE GASTROINTESTINAL EPITHELIUM. TO BROADEN OUR INFLUENZA VIRUS RDRP INHIBITOR PORTFOLIO, WE HAVE IDENTIFIED A SET OF NON-NUCLEOSIDE RDRP INHIBITORS IN A LARGE-SCALE HIGH-THROUGHPUT SCREENING CAMPAIGN THAT WILL BE ADVANCED SIMULTANEOUSLY AS COMPANION DRUGS OR FOR COMBINATION THERAPY IN A MULTI- PRONGED APPROACH. TO SELECT A CLINICAL CANDIDATE FOR FORMAL DEVELOPMENT, 4’-FLU PRODRUG CONJUGATES WILL BE SUBJECTED TO DE-RISKING EFFICACY AND TOLERABILITY TESTING IN RELEVANT RODENT AND NON-RODENT ANIMAL MODELS AND DOSING PARADIGMS EXPLORED THROUGH INTERFACING OF DYNAMIC PK PROFILES WITH PERFORMANCE IN HUMAN AIRWAY EPITHELIUM ORGANOIDS (AIM 1). NON-NUCLEOSIDE RDRP INHIBITOR LEAD CANDIDATE SCAFFOLDS WILL BE SYNTHETICALLY DEVELOPED, MECHANISTICALLY CHARACTERIZED, AND SUBJECTED TO PROOF-OF-CONCEPT EFFICACY TESTING (AIM 2). EMERGING NON-NUCLEOSIDE LEADS WILL BE QUERIED FOR COMBINATION THERAPY WITH THE 4’-FLU CLINICAL CANDIDATE AND THE EFFECT OF MONO- AND COMBINATION THERAPY ON SUPPRESSING INFLUENZA VIRUS TRANSMISSION DETERMINED IN FERRETS (AIM 3).

1) TO SUPPORT FOR A PROGRAM AS DESCRIBED IN "DUAL MASTER'S PROGRAM IN APPLIED ECONOMMICS FOR INDONESIANS";2) TO OBLIGATE FUNDS $805 267;3) TO PR

PERSONALIZED INTEGRATED ALCOHOL AND SEXUAL ASSAULT PREVENTION AMONG COLLEGE STUDENTS - PROJECT ABSTRACT THE OVERARCHING GOAL OF THIS R01 IS TO TEST THE EFFICACY OF A BEHAVIORAL INTERVENTION FOR HEAVY EPISODIC DRINKING (HED) AND SEXUAL ASSAULT AMONG COLLEGE STUDENTS. SEXUAL AND GENDER MINORITY (SGM) STUDENTS EXPERIENCE SEXUAL ASSAULT AND ENGAGE IN HED AT EVEN HIGHER RATES THAN THEIR CISGENDER, HETEROSEXUAL PEERS. THEREFORE, TAILORED AND PERSONALIZED INTERVENTIONS ARE NEEDED FOR HED AND SEXUAL ASSAULT TO ADDRESS THE UNIQUE NEEDS OF COLLEGE STUDENTS BASED ON GENDER IDENTITY AND SEXUAL ORIENTATION. THE ALCOHOL AND SEXUAL ASSAULT PREVENTION (ASAP) PROGRAM WAS DEVELOPED BY THE RESEARCH TEAM WITH AN NIAAA-FUNDED PLANNING GRANT (R34) AND IS THE ONLY INTERVENTION THAT TARGETS BOTH HED AND SEXUAL ASSAULT (VICTIMIZATION RISK REDUCTION, PERPETRATION PREVENTION, AND BYSTANDER INTERVENTION TRAINING) IN AN INTEGRATED MANNER. ASAP PROVIDES TAILORED CONTENT ON ALCOHOL USE AND SEXUAL ASSAULT BASED ON GENDER IDENTITY AND SEXUAL ORIENTATION USING A SOCIAL NORMS AND PERSONALIZED FEEDBACK APPROACH. USABILITY TESTING AND FINDINGS FROM A RANDOMIZED CONTROLLED PILOT FEASIBILITY TRIAL SUGGEST USABILITY, FEASIBILITY, AND PRELIMINARY EFFICACY AND WARRANT RIGOROUS RANDOMIZED CONTROLLED TRIAL TESTING. ASAP IS DELIVERED IN A BRIEF, WEB-BASED FORMAT, AND ALTHOUGH SHORT-TERM OUTCOMES ARE PROMISING, MORE EFFORT IS NEEDED TO ENSURE LONG-TERM EFFICACY. THEREFORE, THE CURRENT STUDY INCLUDES AN ASSESSMENT OF ASAP AS WELL AS AN INNOVATIVE ASSESSMENT OF A 6-MONTH BOOSTER (ASAP+BOOSTER) SESSION TO DETERMINE THE MOST EFFECTIVE WAY TO DISSEMINATE ASAP TO COLLEGES NATIONWIDE IF FOUND TO BE EFFECTIVE. THE CURRENT STUDY INCLUDES THE FOLLOWING AIMS: 1A) TO TEST THE EFFICACY OF ASAP AND ASAP+BOOSTER AMONG COLLEGE STUDENTS IN REDUCING HED AND SEXUAL ASSAULT BOTH SHORT- AND LONG-TERM AMONG THREE RISK GROUPS (1. CISGENDER HETEROSEXUAL MEN; 2. CISGENDER HETEROSEXUAL WOMEN; 3. SGM); 1B) TEST THE RELATIVE EFFICACY OF A BOOSTER SESSION ON LONG-TERM ALCOHOL USE AND SA OUTCOMES; AND 2) INVESTIGATE THE MECHANISMS THROUGH WHICH ASAP CONDITIONS IMPACT ALCOHOL USE AND SA. OUTCOMES WILL BE ASSESSED AT 3-, 6-, 9-, AND 12-MONTHS POST- INTERVENTION. BY ACCOMPLISHING THESE AIMS, WE WILL ASSESS THE EFFICACY OF ASAP, A PROMISING INTERVENTION DEVELOPED BY THE RESEARCH TEAM. ASAP HAS THE POTENTIAL TO REDUCE ALCOHOL USE AMONG YOUNG ADULTS AS WELL AS REDUCE COLLEGE SA AND INCLUDES A FOCUS ON SGM POPULATIONS, ADDRESSING NIAAA AND PUBLIC HEALTH PRIORITIES.

SEX DIFFERENCES IN THE SOCIAL BRAIN

LIBERATE

"(03 MURI) GENETICALLY-ENGINEERED MICRODEVICRS (GEMS) WITH TAILORED 3-D SHAPES, NANOSCALE FEATURES, AND CHEMISTRIES"

PROMOTING PROSOCIAL BYSTANDER BEHAVIOR IN INTOXICATED MEN: EVALUATION OF REALCONSENT2.0

NEUROBIOLOGY OF SOCIAL BEHAVIOR

GRADUATE RESEARCH FELLOWSHIP PROGRAM

PAWS: EFFICACY

INFANT-TODDLER COURT PROGRAM - CENTER OF EXCELLENCE FOR CHILDREN’S BEHAVIORAL HEALTH GEORGIA HEALTH POLICY CENTER GEORGIA STATE UNIVERSITY 55 PARK PLACE, ATLANTA, GA 30303 (404) 413-0314 HTTPS://GACOEONLINE.GSU.EDU/ PROJECT DIRECTOR: ANN MUKHERJEE, MPP EMAIL ADDRESS: AHEDGES@GSU.EDU THE CENTER OF EXCELLENCE FOR CHILDREN’S BEHAVIORAL HEALTH (COE OR CENTER) IS SEEKING HRSA FUNDING OPPORTUNITY HRSA-22-073, INFANT-TODDLER COURT PROGRAM – STATE AWARD. THE CENTER IS SEEKING $625,000 PER YEAR FOR A 5-YEAR PROJECT PERIOD. THE CENTER PROPOSES A 5-YEAR PROJECT BEGINNING WITH A YEARLONG PLANNING PHASE TO DEVELOP AN INFANT-TODDLER COURT (ITC) LEADERSHIP TEAM AND STATEWIDE ACTION PLAN THAT WILL GUIDE 4 YEARS OF ITC IMPLEMENTATION. DURING IMPLEMENTATION, THE COE WILL INITIATE 3 ITC TEAMS IN LOCAL JURISDICTIONS THROUGH A REQUEST FOR APPLICATIONS (RFA) PROCESS AND PROVIDE STATEWIDE LEADERSHIP AND COORDINATION TO INCREASE CAPACITY FOR AND KNOWLEDGE OF THE ITC APPROACH ACROSS THE STATE. THE GOAL OF GEORGIA’S INFANT-TODDLER COURT (ITC) PROGRAM IS TO IMPROVE STATEWIDE SYSTEMS AND POLICIES TO SUPPORT YOUNG CHILDREN (AGES 0-3) AND THEIR FAMILIES WHO ARE INVOLVED, OR AT RISK OF INVOLVEMENT, WITH THE CHILD WELFARE SYSTEM, AND BUILD CAPACITY TO PREVENT CHILD MALTREATMENT MORE BROADLY. THE STATE WILL ACHIEVE THIS GOAL BY EXPANDING EVIDENCE-BASED INFANT-TODDLER COURT TEAMS AND IMPROVING EARLY DEVELOPMENTAL HEALTH AND WELL-BEING OF INFANTS, TODDLERS, AND THEIR FAMILIES BY COMPLETING THE FOLLOWING OBJECTIVES: ESTABLISH LEADERSHIP CAPACITY IN GEORGIA TO INFORM ITC IMPLEMENTATION THROUGH THE CREATION AND TRAINING OF A STATE-LEVEL ITC LEADERSHIP TEAM. THE LEADERSHIP TEAM WILL INCLUDE STATE-LEVEL PARTNERS, LOCAL LEADERS, AND FAMILIES WITH LIVED EXPERIENCE. DEVELOP A STATE ACTION PLAN TO GUIDE ITC IMPLEMENTATION IN THE STATE THROUGH A SYSTEMATIC PROCESS LED BY THE STATE-LEVEL ITC LEADERSHIP TEAM AND INVOLVING THE ITC NATIONAL RESOURCE CENTER, RELEVANT STAKEHOLDERS, AND FAMILIES WITH LIVED EXPERIEN CE. INCREASE CAPACITY THROUGH TRAINING OF STATE AND LOCAL PARTNERS IN THE ITC APPROACH AND TOPICS RELATED TO THE DEVELOPMENTAL HEALTH, MENTAL HEALTH, AND WELL-BEING OF VERY YOUNG CHILDREN. ESTABLISH LOCAL CAPACITY FOR ITC IMPLEMENTATION BY ESTABLISHING THREE LOCAL ITC SITES THROUGH A REQUEST FOR APPLICATIONS PROCESS INFORMED BY THE STATE ACTION PLAN, ITC LEADERSHIP TEAM, AND FAMILIES WITH LIVED EXPERIENCE. IMPROVE YOUTH AND FAMILY OUTCOMES DURING AND AFTER CHILD WELFARE AND/OR COURT INVOLVEMENT DEMONSTRATED THROUGH COLLECTION AND EVALUATION OF PROGRAM OUTCOMES DATA AT THE THREE LOCAL ITC SITES. ESTABLISH SUSTAINABILITY AND SCALING PLANS UTILIZING EVALUATION DATA AND LEARNINGS FROM IMPLEMENTATION TO INFORM SUSTAINABILITY AND FUTURE SCALING OF THE MODEL ACROSS GEORGIA. THE COE IS POSITIONED TO LEAD THIS WORK GIVEN ITS CURRENT LEADERSHIP IN STATEWIDE INITIATIVES BUILDING INFANT AND EARLY CHILDHOOD SYSTEMS OF CARE AND DEVELOPING SYSTEMS OF CARE FOR CHILDREN WITH BEHAVIORAL HEALTH NEEDS. THE CENTER HAS ESTABLISHED MULTI-SECTOR AND CROSS-AGENCY PARTNERSHIPS THROUGHOUT THE STATE, INCLUDING CONNECTIONS AND ENGAGEMENT WITH FAMILIES WHO HAVE LIVED EXPERIENCE NAVIGATING SERVICES FOR THEIR YOUNG CHILDREN ACROSS MULTIPLE STATE AGENCIES. THE COE AND ITS PARTNERS RECOGNIZE THE INCREDIBLE IMPORTANCE OF THE PRENATAL TO 3 PERIOD OF LIFE. THIS FOUNDATION OF COMMON UNDERSTANDING THAT YOUNG CHILDREN HAVE UNIQUE DEVELOPMENTAL NEEDS IS A STRENGTH OF THE STATE PARTNERS AND WILL HELP THE LEADERSHIP TEAM TRANSITION QUICKLY FROM KICK-OFF TO PLANNING AND IMPLEMENTATION.

ESTABLISHING SMOKE-FREE HOMES WITH FAMILIES INVOLVED IN CHILD PROTECTIVE SERVICES: AN EFFECTIVENESS-IMPLEMENTATION TRIAL OF AN INTEGRATED PROGRAM - PROJECT ABSTRACT CHILD EXPOSURE TO SECONDHAND SMOKE (SHS) IS LINKED TO MULTIPLE FORMS OF CANCER THROUGHOUT THE LIFESPAN. YOUNG CHILDREN LIVING IN LOW-SOCIOECONOMIC STATUS HOUSEHOLDS ARE AT INCREASED RISK FOR SHS EXPOSURE. FAMILIES INVOLVED WITH THE CHILD PROTECTION SYSTEM AS THE RESULT OF SUBSTANTIATED CHILD MALTREATMENT ARE AN ESPECIALLY HIGH-RISK GROUP FOR SHS, AS THESE FAMILIES ARE OFTEN LIVING IN POVERTY AND REPORT HIGH DAILY SMOKING RATES. IMPORTANTLY, CHILD MALTREATMENT VICTIMIZATION ALSO INCREASES RISK OF CANCER AND PREMATURE DEATH FROM CANCER, INDEPENDENT OF PARENT SMOKING BEHAVIOR. IDENTIFYING WAYS TO BROADLY DISSEMINATE EFFECTIVE SHS PREVENTION PROGRAMS TO THESE HIGH-RISK FAMILIES IS AN IMPORTANT STRATEGY FOR REDUCING CANCER DISPARITIES. WE PROPOSE AN EFFECTIVENESS-IMPLEMENTATION HYBRID TRIAL TYPE 1 TO EXAMINE THE IMPACT OF INTEGRATING TWO EVIDENCE-BASED PROGRAMS, SOME THINGS ARE BETTER OUTSIDE (SHS PREVENTION PROGRAM) AND SAFECARE® (CHILD MALTREATMENT PREVENTION PROGRAM), ON ESTABLISHING A SMOKE-FREE HOME AND ON IMPLEMENTATION PROCESS OUTCOMES. AIM 1 FOCUSES ON THE REFINEMENT OF THE STANDARDIZED INTEGRATION (SYSTEMATIC BRAIDING) OF THE TWO PROGRAMS INTO “SMOKE-FREE SAFECARE (SFSC).” AIMS 2 AND 3 FOCUS ON THE HYBRID TRIAL. FIFTY CERTIFIED SAFECARE PROVIDERS WILL BE RECRUITED AND RANDOMLY ASSIGNED TO DELIVER EITHER SFSC OR STANDARD SAFECARE. PROVIDERS WILL EACH SERVE TEN RESEARCH FAMILIES (N = 500) WHO MEET THE INCLUSION CRITERIA (MOTHER OR ANOTHER PERSON RESIDING IN THE HOME SMOKES AT HOME). THE PRIMARY OUTCOME, SMOKE-FREE HOME STATUS, WILL BE MEASURED VIA SELF-REPORT AT 4-TIMEPOINTS (BASELINE, 8-WEEKS, 20-WEEKS, AND 1-YEAR), AND VALIDATED VIA AIR NICOTINE MONITOR AT 8 WEEKS AND 1-YEAR (AIM 2). PROCESS MEASURES WILL BE COLLECTED TO EXAMINE HOW THE BRAIDED INTERVENTION IMPACTS PROVIDER FIDELITY, DELIVERY TIME AND COSTS, AND OTHER PROCESS MEASURES (AIM 3). IF EFFECTIVE, SFSC CAN BE EFFICIENTLY DISSEMINATED FOR WIDESPREAD ADOPTION BY THE NATIONAL SAFECARE TRAINING AND RESEARCH CENTER TO THE OVER 100 ACCREDITED SAFECARE AGENCIES ACROSS THE UNITED STATES AND WORLDWIDE THAT SERVE PARENTS INVOLVED WITH CHILD PROTECTION SERVICES, REDUCING CANCER RISK AND DISPARITIES FOR A HIGH-RISK POPULATION.

ORTHOGONAL UBIQUITIN TRANSFER TO PROFILE E3 SUBSTRATE SPECIFICITY

CYBERCORPS SCHOLARSHIP FOR SERVICE: CYBERSECURITY WORKFORCE PREPARATION IN THE AGE OF ARTIFICIAL INTELLIGENCE -THIS PROJECT AIMS TO ADDRESS THE GROWING NEED FOR A HIGHLY-SKILLED NATIONAL CYBERSECURITY WORKFORCE CAPABLE OF RESPONDING TO RAPIDLY EVOLVING CHALLENGES IN THE AGE OF ARTIFICIAL INTELLIGENCE (AI). WITH FUNDING FROM THE NSF CYBERCORPS(R) SCHOLARSHIP FOR SERVICE (SFS) PROGRAM, GEORGIA STATE UNIVERSITY (GSU) WILL PRODUCE GRADUATES CAPABLE OF ASSUMING A VARIETY OF CYBERSECURITY ROLES IN THE U.S. GOVERNMENT. MOREOVER, THE PROJECT WILL INCREASE THE DIVERSITY OF THE FEDERAL CYBERSECURITY WORKFORCE, LEVERAGING GSU'S POSITION AS A MINORITY-SERVING INSTITUTION (MSI). THE SFS PROJECT WILL EMPHASIZE RECRUITING AND GRADUATING HIGHLY QUALIFIED CANDIDATES FROM GROUPS THAT HAVE REMAINED UNDERREPRESENTED IN THE CYBERSECURITY FIELD, INCLUDING THOSE WITH MILITARY-AFFILIATIONS, FIRST-GENERATION COLLEGE ATTENDEES, AND LOW-INCOME STUDENTS. THIS PROJECT'S UNIQUE AND INNOVATIVE FOCUS WILL IMPACT THE NATION'S COMPETITIVENESS AND THE U.S. GOVERNMENT BY PRODUCING HIGHLY SKILLED CYBERSECURITY PROFESSIONALS WHO CAN DEVELOP AND DEPLOY TRUSTWORTHY CYBERSYSTEMS TO ADDRESS GRAND CHALLENGES FACING SOCIETY. GSU HAS ESTABLISHED A STRONG CURRICULUM IN CYBERSECURITY AND PRIVACY THAT BALANCES TECHNICAL RIGOR AND HANDS-ON EXPERIENCES, OFFERING STUDENTS THE OPPORTUNITY TO STUDY VARIOUS TOPICS IN CYBERSECURITY AND PRIVACY. THE PROJECT FOCUSES ON TRAINING AND PREPARING A WORKFORCE WITH INTEGRATED CYBERSECURITY, PRIVACY, AI, AND MACHINE LEARNING COMPETENCIES TO APPLY AI EXPERTISE TO CYBERSECURITY AND BUILD ROBUST AND TRUSTWORTHY AI SYSTEMS. STUDENTS WILL BE PREPARED WITH THE KNOWLEDGE AND PRACTICAL SKILLS TO APPLY AI EXPERTISE AND UNDERSTAND AI'S SAFETY, SECURITY, PRIVACY, RELIABILITY, FAIRNESS, AND ETHICAL IMPLICATIONS. OVER A FIVE-YEAR PERIOD THE PROJECT WILL PROVIDE SCHOLARSHIPS TO 25 STUDENTS STUDYING ISSUES AT THE INTERSECTION OF CYBERSECURITY AND AI. THE SFS STUDENTS WILL PARTICIPATE IN AN INTENSIVE ACADEMIC PROGRAM IN CYBERSECURITY, PRIVACY, AND TRUSTWORTHY AI, INCLUDING COURSEWORK AND RESEARCH IN CUTTING-EDGE AREAS TO SHARPEN THE STUDENTS' ABILITY FOR CREATIVE THINKING, MAKING THEM BETTER CYBERSECURITY PROFESSIONALS. IN ADDITION TO COMPLETING RIGOROUS, REQUIRED COURSEWORK, THE SFS SCHOLARS WILL ENGAGE IN EXPERIENTIAL LEARNING THROUGH OPPORTUNITIES FOR INDIVIDUAL AND GROUP RESEARCH PROJECTS AND OTHER EXTRACURRICULAR ACTIVITIES, WHICH WILL PROVIDED DEEPLY TECHNICAL AS WELL AS INTERDISCIPLINARY LEARNING EXPERIENCES AND LEADERSHIP DEVELOPMENT TAILORED TO EACH STUDENT'S PREPARATION AND ASPIRATION. THIS PROJECT IS SUPPORTED BY THE CYBERCORPS(R) SCHOLARSHIP FOR SERVICE (SFS) PROGRAM, WHICH FUNDS PROPOSALS ESTABLISHING OR CONTINUING SCHOLARSHIP PROGRAMS IN CYBERSECURITY AND ALIGNS WITH THE U.S. NATIONAL CYBER STRATEGY TO DEVELOP A SUPERIOR CYBERSECURITY WORKFORCE. FOLLOWING GRADUATION, SCHOLARSHIP RECIPIENTS ARE REQUIRED TO WORK IN CYBERSECURITY FOR A FEDERAL, STATE, LOCAL, OR TRIBAL GOVERNMENT ORGANIZATION FOR THE SAME DURATION AS THEIR SCHOLARSHIP SUPPORT. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

SEX DIFFERENCES IN STRESS INOCULATION OF ADDICTION-LIKE PHENOTYPES

ASSESSING THE EFFECTIVENESS OF THE SECOND CHANCE ACT GRANT PROGRAM THROUGH A PHASED EVALUATION APPROACH USING AN IMPLEMENTATION SCIENCE MIXED METHODS APPROACH

DATA-DRIVEN SOLUTIONS FOR TEMPORAL, SPATIAL, AND SPATIOTEMPORAL DYNAMIC FUNCTIONAL CONNECTIVITY - PROJECT SUMMARY/ABSTRACT EXISTING APPROACHES TO ESTIMATE AND CHARACTERIZE WHOLE BRAIN TIME-VARYING CONNECTIVITY FROM FMRI DATA HAVE SHOWN CONSIDERABLE PROMISE, WITH EXPONENTIAL GROWTH IN RESEARCH IN THIS FIELD. WE AND OTHERS HAVE DEVELOPED A POWERFUL SET OF TOOLS THAT ARE NOW IN WIDE USE IN THE COMMUNITY. HOWEVER, THE IMPACT OF MENTAL ILLNESS ON BRAIN CONNECTIVITY IS COMPLEX, AND AS WE SHOW, LIMITATIONS IN EXISTING METHODS OFTEN RESULT IN MISSING IMPORTANT FEATURES ASSOCIATED WITH BRAIN DISORDERS (E.G. TRANSIENT FRACTIONATION OF THE SPATIAL STRUCTURE OF BRAIN NETWORKS). SOME OF THESE IMPORTANT LIMITATIONS INCLUDE 1) THE MOST WIDELY-USED APPROACHES OFTEN REQUIRE A NUMBER OF PRIOR AND LIMITING ASSUMPTIONS THAT ARE NOT WELL STUDIED, 2) METHODS OFTEN ASSUME LINEAR RELATIONSHIPS EITHER WITHIN OR BETWEEN NETWORKS OVER TIME, AND 3) METHODS ASSUME SPATIALLY FIXED NODES AND IGNORE THE POSSIBILITY OF SPATIALLY FLUID EVOLUTION OF NETWORKS OVER TIME. WE PROPOSE A NOVEL FAMILY OF MODELS THAT BUILDS ON THE WELL-STRUCTURED FRAMEWORK OF JOINT BLIND SOURCE SEPARATION TO CAPTURE A MORE COMPLETE CHARACTERIZATION OF (POTENTIALLY NONLINEAR) SPATIO-TEMPORAL DYNAMICS WHILE PROVIDING A WAY TO RELAX OTHER LIMITING ASSUMPTIONS. OUR MODELS WILL ALSO PRODUCE A RICH SET OF METRICS TO CHARACTERIZE THE AVAILABLE DYNAMICS AND ENABLE IN DEPTH COMPARISON WITH CURRENTLY AVAIL- ABLE MODELS INCLUDING THOSE THAT ARE MODEL BASED. WE WILL EXTENSIVELY VALIDATE OUR APPROACHES IN A VARIETY OF WAYS INCLUDING SIMULATIONS AND EVALUATION OF RIGOR AND ROBUSTNESS IN LARGE NORMATIVE DATA SETS. FINALLY, WE WILL APPLY THE DEVELOPED TOOLS TO STUDY THE IMPORTANT AREA OF DYNAMIC PROPERTIES IN MENTAL ILLNESSES INCLUDING SCHIZ- OPHRENIA, BIPOLAR DISORDER, AND THE AUTISM SPECTRUM. THERE IS CONSIDERABLE EVIDENCE OF DISRUPTION OF DYNAMICS IN ALL THREE DISORDERS, AND AS WE SHOW THE USE OF STATIC (OR EVEN EXITING DYNAMIC) APPROACHES CAN MISS IMPORTANT INFORMATION ABOUT BRAIN RELATED DIFFERENCES ASSOCIATED WITH EACH. WE WILL PROVIDE OPEN SOURCE TOOLS AND RELEASE DATA THROUGHOUT THE DURATION OF THE PROJECT VIA A WEB PORTAL AND THE NITRC REPOSITORY, HENCE ENABLING OTHER INVESTIGATORS TO USE OUR APPROACHES AND COMPARE THEIR OWN METHODS WITH OUR OWN. OUR TOOLS HAVE WIDE APPLI- CATION TO THE STUDY OF THE HEALTHY BRAIN AS WELL AS MANY OTHER DISEASES SUCH AS ALZHEIMER'S DISEASE AND ATTENTION DEFICIT HYPERACTIVITY DISORDER. 38

CRCNS: CYTOSKELETAL MECHANISMS OF DENDRITE ARBOR SHAPE DEVELOPMENT