Eastern Virginia Medical School

AWARDED TO EASTERN VIRGINIA MEDICAL SCHOOL IN SUPPORT OF THE CONRAD-PPRD PROGRAM.

COMPLETION OF PHASE III CLINICAL TRIAL, NEW DRUG APPLICATION DOSSIER, AND IMPLEMENTATION STUDIES FOR TENOFOVIR 1% GEL, A FIRST-IN-CLASS TOPICAL PROD

APP FOR AAD 936-3090

TO INCREASE THE TEC TO $109,000,000 AND TO EXTEND THE COOPERATIVE AGREEMENT TO AUGUST 13, 2009.

NEXT GENERATION PRODUCTS FOR PREVENTION OF HIV INFECTION IN WOMEN (NIX HIV)

PRH/RTU-BIO: CONRAD COMBINED CONTRACEPTIVE/HIV PREVENTION PRODUCT

APP FOR AAD 936-3090

ADDRESSING LOW-INCOME HOUSING RESIDENT MISTRUST IN COVID-19 GUIDANCE

BRAIN MACROPHAGE RESERVOIRS OF HIV DURING SUPPRESSIVE ART

LIMBIC MODULATION OF STRESS-INDUCED ALTERATIONS IN SLEEP

NOVEL TOOLS FOR THE NONINVASIVE EVALUATION OF THE HUMAN PLACENTA

DEVELOPMENT OF PROTEIN BIOMARKERS IN POST-DRE URINE FOR USE IN LIQUID BIOPSY OF PROSTATE CANCER

NOVEL LONG-ACTING MICROBICIDE AND CONTRACEPTIVE INTRAUTERINE SYSTEM

DIFFERENTIAL HIV INFECTION AND TENOFOVIR ACTIVITY IN PRE AND POSTMENOPAUSAL WOMEN

MYELOID CELL-SPECIFIC ROLE OF STAT4 IN ATHEROSCLEROSIS AND METABOLIC DYSFUNCTION

PROJECT HORIZON: HYDROGEL INJECTABLE DEPOT SYSTEM FOR NEXT-GENERATION LONG-ACTING HIV PREVENTION AND CONTRACEPTION

ROLE OF THE INTERLEUKIN12/STAT4 PATHWAY IN INSULIN RESISTANCE AND ATHEROSCLEROSIS

TARGETING MEMBRANE REPAIR IN DEFORMATION-INDUCED LUNG INJURY

B CELL ANERGY, MODIFIED LDL UPTAKE, AND ATHEROSCLEROSIS

PRE-DOCTORAL TRAINING IN PRIMARY CARE

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

MECHANISMS OF CORONARY ARTERIOLAR DYSFUNCTION IN TYPE 2 DIABETES

MICROBICIDES APS ROUND 2

T CELL PLASTICITY IN ATHEROSCLEROSIS

PRH/RTU-APS ON BIOMEDICAL RESEARCH

PROTEINS MEDIATING INTERACTION OF HIV-1 AND JCV IN CNS

PROSTAGLANDIN RECEPTORS IN PRIMATE OVULATORY FOLLICLES

HTLV-1 TAX DISRUPTS DNA DAMAGE REPAIR-RESPONSE COMPLEXES

PRIMARY CARE TRAINING AND ENHANCEMENT

HISTONE H4 LYSINE16 ACETYLATION IN AGING AND LUNG FIBROSIS

PUBLIC HEALTH TRAINING CENTER

IDENTIFICATION AND CHARACTERIZATION OF DRIVER GENE(S) IN RECURRENT LUNG CANCER AM

SIAH2-DEPENDENT PROTEOLYSIS IN CELL MIGRATION TUMOR GROWTH AND CANCER METASTASIS

THE GOAL OF THIS APPLICATION IS TO USE PROTEOMIC PROFILING/IMAGING TO ESTABLISH THE MECHANISTIC BASIS OF HZE-INDUCED COGNITIVE IMPAIRMENT. OUR UNDERL

NOVEL COMBINATION THERAPIES TO REVERSE TYPE 1 DIABETES

PROTEOMIC AIDED INVEST/MECHANISTIC BASIS FOR HZE INDUCED COGNITIVE IMPAIRMENT/DEV.DIAGNOSTIC

EARLY DETECTION OF CANCER BY AFFINITY MASS SPECTROMETRY

EVMS - CARES ACT INSTITUTIONAL PORTION 18004 (A)1

PSMA GLYCOSYLATION AND AGGRESSIVE PROSTATE CANCER PROGRESSION

LEAD HEALTHY HOME

PHYSICIAN ASSISTANT TRAINING IN PRIMARY CARE

ARRA - TRAINING IN PRIMARY CARE MEDICINE AND DENTISTRY: RESIDENCY TRAINING IN PRIMARY CARE

CARES ACT EMERGENCY FINANCIAL ASSISTANCE GRANT TO STUDENTS DUE TO COVID-19 RELATED DISRUPTION TO CAMPUS OPERATIONS

A-TO-I RNA MODIFICATIONS IN MOUSE OOCYTES - PROJECT SUMMARY/ABSTRACT THE PRIMARY OBJECTIVE OF THIS PROPOSAL IS TO FACILITATE THE DEVELOPMENT OF DR. BRACHOVA INTO AN INDEPENDENT RESEARCH SCIENTIST. THIS OBJECTIVE WILL BE ACCOMPLISHED THROUGH A COMBINATION OF ACTIVE MENTORSHIP, DIDACTIC TRAINING, ENRICHMENT ACTIVITIES, AND RESEARCH. THE MENTORSHIP PHASE IS WELL DESCRIBED BY HER MENTORS AND INCLUDES WEEKLY CONTACT AND FORMAL COURSE WORK. THE CORE OF THE RESEARCH FOCUSES ON THE ROLE OF A POST- TRANSCRIPTIONAL REGULATION MECHANISM KNOWN AS RNA EDITING IN OVERALL OOCYTE QUALITY. DEFECTS IN OOCYTE GROWTH AND MEIOTIC MATURATION REPRESENT A SIGNIFICANT CAUSE OF HUMAN BIRTH DEFECTS, MISCARRIAGE, AND INFERTILITY. THE CONTRIBUTION OF RNA POST-TRANSCRIPTIONAL MODIFICATIONS IS EMERGING AS AN IMPORTANT REGULATOR OF RNA STABILITY AND OOCYTE QUALITY, HOWEVER THE ROLE OF ADENOSINE DEAMINASE ACTING ON DOUBLE STRANDED RNA (ADAR1), WHICH CATALYZES THE DEAMINATION OF AN ADENOSINE (A) INTO INOSINE (I) REMAINS UNEXPLORED. THE GOAL OF THIS RESEARCH IS TO DETERMINE THE EFFECT OF ADAR1 RNA EDITING ON RNA STABILITY AND OOCYTE COMPETENCE IN YOUNG AND OLD MICE. PRELIMINARY DATA SHOW THAT ADARFL/FLZP3-CRE OOCYTES HAVE REDUCED EMBRYONIC DEVELOPMENTAL POTENTIAL, SUGGESTING THAT ADAR1 IS A NOVEL FACTOR THAT CONTRIBUTES TO FEMALE FERTILITY. WE ALSO SHOW THAT OOCYTES AND EGGS FROM AGED INDIVIDUALS HAVE REDUCED RNA EDITING EFFICIENCY, SUGGESTING THAT RNA EDITING DEFICIENCIES COULD BE INVOLVED IN FEMALE AGE-ASSOCIATED DECLINE OF FERTILITY. THE CENTRAL HYPOTHESIS IS THAT ADAR1 RNA EDITING IS A NOVEL MECHANISM FOR MAINTAINING FEMALE FERTILITY THROUGH THE REGULATION OF RNA STABILITY DURING OOCYTE GROWTH AND EARLY EMBRYONIC DEVELOPMENT. THE HYPOTHESIS WILL BE TESTED IN TWO INDEPENDENT SPECIFIC AIMS. SPECIFIC AIM 1 WILL ASSESS THE ROLE OF ADAR1 A-TO-I RNA EDITING IN THE REGULATION OF MATERNAL MRNA DOSAGE IN THE OOCYTE AND EARLY EMBRYO. SPECIFIC AIM 2 WILL DETERMINE HOW ADAR1 A-TO-I RNA EDITING EFFECTS MRNA DEGRADATION IN OOCYTES. THE PROPOSED RESEARCH WILL UTILIZE OOCYTES AND EGGS FROM YOUNG AND MATERNALLY AGED MICE TO EXPLORE THE ROLE OF A-TO-I EDITING IN OOGENESIS AND AGE-RELATED REDUCTION IN FERTILITY. THIS PROPOSAL REPRESENTS AN INNOVATIVE APPROACH TO STUDY OOCYTE COMPETENCE, AND HAS THE POTENTIAL TO EXPAND OUR UNDERSTANDING OF FEMALE FERTILITY. FURTHERMORE, THE STUDIES PROPOSED HEREIN ARE INTEGRAL TO ENHANCE THE SCIENTIFIC TRAINING OF DR. BRACHOVA AND ENABLE HER TO ACCOMPLISH HER GOAL OF ACHIEVING INDEPENDENCE AND BECOMING AN INDEPENDENT SCIENTIST IN THE FIELD OF FEMALE REPRODUCTION.

CNS PATHOLOGY AFTER HSV INFECTION IS IMMUNE CELL-MEDIATED

MECHANISM OF THIN FILAMENT REGULATION OF CARDIAC ACTOMYOSIN HYDROLYSIS

WNT5A AND PLANAR CELL POLARITY IN KIDNEY DEVELOPMENT AND CYST FORMATION

TARGETING SIAH E3 LIGASE DOWNSTREAM OF THE HER2/NEU/RAS SIGNALING PATHWAY TO BLOCK TUMORIGENESIS AND METASTASIS OF HIGHLY INVASIVE HUMAN BREAST CANCE

PHENOTYPICAL EXPRESSION OF ANXIETY AND SLEEP

ORAL POLIO VACCINE CIRCULATION IN MEXICO

LEAD-BASED PAINT HAZARD CONTROL IN PRIVATELY-OWNED HOUSING

THE EFFECT OF DEAFNESS ASSOCIATED MUTATIONS ON MYOSINVIIA FUNCTION

GRADUATE PSYCHOLOGY EDUCATION PROGRAMS

TARGETING BRAIN MACROPHAGE RESERVOIRS OF INFECTION IN PEDIATRIC NEUROAIDS

TUNING OF INNATE IMMUNITY IN LOCAL LUNG

HEALTHY HOMES ASTHMA INVENTION

CANNABINOID-2 RECEPTOR SIGNALING IN VESICANT INDUCED LUNG INJURY - SULFUR MUSTARD (SM), A VESICANT THAT IS ONE OF THE MOST LETHAL CHEMICAL WARFARE AGENTS, REMAINS AS A GREAT THREAT IN MODERN TIMES. EXPOSURE TO SM AND ITS MONO-FUNCTIONAL ANALOG 2-CHLOROETHYL ETHYL SULFIDE (CEES) INDUCES DELETERIOUS EFFECTS ON THE LUNG. OXIDATIVE STRESS AND UNCONTROLLED INFLAMMATION ARE CONSIDERED AS THE MAJOR MECHANISMS OF SM TOXICITY ON THE LUNG. CURRENTLY, THERE ARE NO EFFECTIVE MEDICAL COUNTERMEASURES TO MITIGATE THE VESICANT INDUCED LUNG DAMAGE. THEREFORE, IT IS ESSENTIAL TO EXPAND OUR UNDERSTANDING OF THE MOLECULAR MECHANISMS AND TO IDENTIFY EFFECTIVE MEASURES, INCLUDING PHARMACOLOGICAL INTERVENTIONS, TO ALLEVIATE THE INFLAMMATION AND OXIDATIVE STRESS INDUCED BY SM. CANNABINOID-2 RECEPTORS (CB2R), EXPRESSED MAINLY IN THE IMMUNE CELLS, HAVE SHOWN PROMISING ANTI-INFLAMMATORY AND ANTI-INJURY POTENTIAL WITHOUT ANY ADVERSE PSYCHOTIC EFFECTS. OUR PRELIMINARY FINDINGS INDICATED A SIGNIFICANT REDUCTION OF CEES- INDUCED ACUTE LUNG INJURY AND IMMUNE CELL INFILTRATION BY PHARMACOLOGICAL ACTIVATION OF CB2R, WHILE THE GENETIC DELETION OF CB2R WORSENED THE LUNG INJURY. MOREOVER, CB2R LIGANDS SHOW MARKED FUNCTIONAL SELECTIVITY, SUGGESTING CB2R CAN BE A GOOD TARGET FOR DEVELOPING COUNTER MEASURES TO CEES. GIVEN THESE PROMISING INDICATIONS, THIS PROJECT AIMS TO FURTHER INVESTIGATE HOW CB2R ACTIVATION ATTENUATES CEES-INDUCED ACUTE LUNG INJURY, USING PHARMACOLOGICAL ACTIVATION AND GENETIC DELETION APPROACH IN THE FOLLOWING SPECIFIC AIMS: 1) TO DETERMINE THE EXTENT TO WHICH CB2R REGULATES THE CEES-INDUCED ACUTE LUNG INJURY, INFLAMMATORY RESPONSE, AND OXIDATIVE STRESS. 2) TO DELINEATE THE MECHANISM OF THE PROTECTIVE ROLE OF CB2R IN CEES-INDUCED LUNG INJURY, INFLAMMATORY RESPONSE, AND OXIDATIVE STRESS. THESE EFFORTS WILL REVEAL A NOVEL MECHANISM OF ENDOCANNABINOID SIGNALING THROUGH CB2R IN CEES-INDUCED LUNG INJURY AND WOULD ASSIST IN TRANSLATIONAL STRATEGIES FOR THE DEVELOPMENT OF THERAPEUTIC AGENT AGAINST VESICANT-INDUCED LUNG DAMAGE.

PEPTIDE INHIBITORS OF OXIDATIVE HEME TOXICITY IN ACUTE HEMOLYSIS

PIC1 INHIBITION OF MYELOPEROXIDASE ACTIVITY AND INFLAMMATION

ROLE OF AMYGDALAR INPUTS TO LOCUS COERULEUS IN SLEEP REGULATION

STRUCTURE AND FUNCTION ANALYSIS OF C1/C1Q AND MBL USING A NOVEL PEPTIDE INHIBITOR

AN APTAMER-BASED BIOSENSOR FOR POINT-OF-CARE MONITORING OF ADHERENCE TO ORAL TENOFOVIR ANTIRETROVIRAL REGIMENS FOR HIV PREVENTION AND TREATMENT

STAPHYLOCOCCUS AUREUS BINDS FACTOR H TO MODERATE COMPLEMENT HOST DEFENSE

VIRAL ENCEPHALITIS, CHEMOKINES AND SLEEP

STRUCTURE AND MECHANISM OF CARDIOMYOPATHY MYOSIN MUTANTS

PCL - ALLOPATHIC MEDICINE - LOAN GRANT WITH FUNDS FOR NEW BUDGET PERIOD

CARES ACT EMERGENCY FINANCIAL ASSISTANCE GRANT TO STUDENTS DUE TO COVID-19

EQUIPMENT ENHANCEMENTS TO THE EVMS VIVARIUM

12/15 LIPOXYGENASES ROLE IN INFLAMMATION AND ANGIOGENESIS IN HUMAN ADIPOSE TISSUE

USING DIFFERENCES IN PERCEIVED LEGITIMACY AND RESIDENT COMPLIANCE TO PROMOTE FAIR AND EFFECTIVE IMPLEMENTATION OF SMOKE FREE HOUSING - PROJECT SUMMARY SMOKE-FREE HOUSING (SFH) HAS RECENTLY BEEN MANDATED BY THE U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) TO PROTECT PUBLIC HOUSING RESIDENTS FROM SECONDHAND SMOKE (SHS) EXPOSURE. HOWEVER, OUR PRELIMINARY WORK SUGGESTS THAT SFH MIGHT NOT BE EFFECTIVE. IN FOCUS GROUPS, SMOKERS IN LOW-INCOME HOUSING HAVE REPORTED TO US THAT THEY ARE PRIMARILY MOTIVATED BY FEAR OF PUNISHMENT, RATHER THAN AN OBLIGATION TO COMPLY WITH SFH, WHICH THEY PERCEIVE TO BE UNFAIR. THEY DESCRIBE A SITUATION IN WHICH MANY SMOKERS RESPOND BY HIDING THEIR SMOKING INSIDE THEIR APARTMENTS—WHERE THEY THINK THEY WILL BE LESS LIKELY TO BE SEEN—WHEN COMPLIANCE WITH SFH IS PERCEIVED TO BE AN INCONVENIENCE OR EVEN UNSAFE (E.G., IF THEY WOULD HAVE TO WALK ACROSS THEIR COMMUNITY AT NIGHT TO SMOKE OFF THE PROPERTY). THIS SUGGESTS THAT THE PERCEIVED LEGITIMACY OF SFH IS LOW—RESIDENTS FEEL SO STRONGLY ABOUT ITS UNFAIRNESS THAT THEY ARE UNLIKELY TO COMPLY WITH IT ON THEIR OWN. THIS MEANS THAT EFFORTS TO INCREASE RESIDENT COMPLIANCE BY RELYING ON THREATS OF PUNISHMENT COULD BE COUNTERPRODUCTIVE. RESIDENTS ALSO REPORT SEVERAL BARRIERS TO COMPLIANCE WITH SFH THAT THEY ALSO PERCEIVE TO BE UNFAIR (E.G., BANNING SMOKING IN PUBLIC HOUSING BUT ALLOWING IT ON OTHER TYPES OF PROPERTIES). THESE BARRIERS VARY BETWEEN HOUSING AUTHORITIES AND REPRESENT IMPORTANT DIFFERENCES IN SFH IMPLEMENTATION STRATEGY. PRINCIPLES AND APPROACHES FROM COMMUNITY-BASED PARTICIPATORY RESEARCH GUIDE THIS STUDY. IN AIM 1 WE ASSESS FACTORS ASSOCIATED WITH PERCEIVED LEGITIMACY AND COMPLIANCE ACROSS SIX HOUSING AUTHORITIES. WE WILL USE A MIXED METHODS APPROACH TO ESTABLISH: (1) WHO EXHIBITS LOWER PERCEIVED LEGITIMACY OF SFH, AND UNDER WHAT CIRCUMSTANCES, AND (2) WHAT PROPERTY AND ORGANIZATIONAL FACTORS THAT DIFFER BETWEEN AND WITHIN HOUSING AUTHORITIES COULD AFFECT SFH IMPLEMENTATION AND RESIDENT COMPLIANCE. IN AIM 2 WE TEST ASSOCIATIONS BETWEEN PERCEIVED LEGITIMACY, SFH IMPLEMENTATION STRATEGY, AND SEVERAL MARKERS FOR SHS (FINE PARTICULATE MATTER, AIRBORNE NICOTINE, AND EXHALED CO). WE HYPOTHESIZE THAT: (A) PERCEIVED LEGITIMACY WILL BE RELATED TO DIFFERENCES IN SFH IMPLEMENTATION, (B) DIFFERENCES IN SFH IMPLEMENTATION STRATEGY WILL AFFECT SFH COMPLIANCE, AS MEASURED BY SHS, AND (C) LOW PERCEIVED LEGITIMACY OF SFH WILL MEDIATE THE IMPACT OF IMPLEMENTATION STRATEGY ON SFH COMPLIANCE. IN AIM 3 WE DEVELOP A SCALABLE IMPLEMENTATION STRATEGY FOR SFH THAT TO IMPROVE RESIDENT COMPLIANCE AND PERCEIVED LEGITIMACY. COMMUNITY ADVISORY BOARDS WILL BE USED TO INFORM THIS PROCESS TO ENSURE THAT SOLUTIONS ARE GROUNDED IN REAL-WORLD EXPERIENCES.

ROLE OF THE EPS URINE-DERIVED MICRORNA MIR-888 IN PROSTATE CANCER PROGRESSION

STRUCTURE OF THE PREPOWERSTROKE CONFORMATION OF ACTOMYOSIN-ADP-PI BY TIME-RESOLVED CRYO-EM

MODIFIER OF CANCER SENSITIVITY TO STATINS

PROXIMAL PROSTATE FLUIDS FOR PROTEIN AND MIRNA BIOMARKERS

CRYO ELECTRON MICROSCOPY OF ACTO-S1 ATPASE INTERMEDIATES

QUALITY OF LIFE TOOL SENSITIVE TO COGNITIVE AND PHYSICAL MEASURES OF FATIGUE

PRIMARY CARE TRAINING AND ENHANCEMENT

GRADUATE PSYCHOLOGY EDUCATION PROGRAMS

LIPID MEDIATORS IN PANCREATIC ISLET DYSFUNCTION

REGULATED PROTEOLYSIS IN RAS SIGNAL TRANSDUCTION

EXTRACELLULAR VESICLES MIRNAS AS MEDIATORS OF SLEEP FRAGMENTATION EFFECTS ON DIABETES AND LIVER DISEASE PROGRESSION

ROLE OF NEUROPEPTIDE Y IN DIABETES AND OBESITY

DEPRESSION: AUTONOMIC-CHOLINERGIC MECHANISMS

GRADUATE PSYCHOLOGY EDUCATION PROGRAMS

REGULATION AND FUNCTION OF THE HCMV PP71 TEGUMENT PROTEIN

LOAN GRANT WITH FUNDS FOR NEW BUDGET PERIOD

EVMS CORONAVIRUS HEERF - FIPSE

MEASURE DEVELOPMENT FOR PREDICTION OF E-CIGARETTE INITIATION

LDS - ALLOPATHIC MEDICINE - LOAN GRANT WITH FUNDS FOR NEW BUDGET PERIOD

ADOLESCENT MARIJUANA USE AND MARIJUANA POSSESSION ARRESTS: HAVE CHANGES IN MARIJUANA POLICY AFFECTED DISPARITIES BETWEEN BLACKS AND WHITES?

CO-REGULATION AND FUNCTION OF PUR-GAMMA AND WRN IN THE CNS

THE ROLE OF MICRORNAS IN PROSTATE CANCER PROGRESSION

ROLE OF PANCREATIC NEUROPEPTIDE Y IN OBESITY AND DIABETES

EXOSOMES AS NOVEL MICRORNA-DELIVERY VEHICLES TO MODULATE PROSTATE CANCER PROGRESSION

INFLAMMATION AND 12/15-LIPOXYGENASE ACTIVITY IN VISCERAL FAT

FUNCTIONAL ANALYSIS OF FREQUENT LUNG CANCER AMPLICONS UNDER CURRENT GENOME ANNOTATION

IDENTIFICATION AND CHARACTERIZATION OF A NEW PERICYTE SUBSET: ROLE IN BLOOD-BRAIN BARRIER BREAKDOWN

EASTERN VA MEDICAL SCHOOL RURAL EASTERN SHORE PARTNERSHIP TO ADDRESS OBESITY

COLLABORATIVE RESEARCH: ABI INNOVATION: INTEGRATIVE ANALYSIS OF THE ANATOMIC AND GENETIC LANDSCAPES IN THE MOUSE BRAIN

SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

EASTERN VA MEDICAL SCHOOL RURAL EASTERN SHORE PARTNERSHIP TO ADDRESS OBESITY

SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

HIV-1 EFFECTS ON TGF-BETA PATHWAY IN AIDS/PML

ARRA - SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

LEAD HEALTHY HOME

RYAN WHITE HIV/AIDS PROGRAM PART C EIS COVID-19 RESPONSE

CLINICAL PRACTICE GUIDELINES FOR EMERGENCY CARE OF CHILDREN

PHYSICIAN ASSISTANT TRAINING IN PRIMARY CARE