High Point University

ASCEND: AMALGAMATING SCHOOL LEADERSHIP CERTIFICATES AND EXECUTIVE COACHING FOR NEW LEADER DEVELOPMENT

HIGH EDUCATION RELIEF FUND - INSTITUTIONAL - HIGH POINT UNIVERSITY

HIGHER EDUCATION EMERGENCY RELIEF FUND - HIGH POINT UNIVERSITY

PREPARE+: PIEDMONT-TRIAD RESIDENCY EDUCATOR PROGRAM AND RECRUITMENT EFFORTS FOR PRINCIPAL LEADERS IN UNDERSERVED SCHOOLS

PREPARE: PIEDMONT - TRIAD RESIDENCY EDUCATOR PROGRAM AND RECRUITMENT EFFORTS

DEVELOPMENT OF HIGH-AFFINITY AND SELECTIVE LIGANDS AS A PHARMACOLOGICAL TOOL FOR THE DOPAMINE D4 RECEPTOR (D4R) SUBTYPE VARIANTS - PROJECT SUMMARY/ABSTRACT THE DOPAMINE D4 RECEPTOR (D4R) PLAYS IMPORTANT ROLES IN COGNITION, ATTENTION, AND DECISION-MAKING. THE HUMAN DRD4 GENE IS HIGHLY POLYMORPHIC, WITH DIFFERENT VARIANTS ASSOCIATED WITH VARIOUS NEUROPSYCHIATRIC DISORDERS. IN PARTICULAR, VNTR VARIANTS (THE THREE MAJOR ONES ARE TERMED D4.2R, D4.4R, AND D4.7R) ARE DIFFERENTIALLY ASSOCIATED WITH ADHD AND SUBSTANCE USE DISORDERS, WITH THE D4.7R RELIABLY ASSOCIATED WITH INCREASED PREVALENCE OF ADHD AND SUBSTANCE USE DISORDERS (SUDS). DETERMINING PRECISE PHYSIOLOGICAL ROLES OF D4R SIGNALING AS WELL AS UNDERSTANDING THE CONSEQUENCES OF D4R VARIANTS IN CONTRIBUTING TO DISEASE STATES HAS BEEN HAMPERED BY THE LACK OF SUITABLE COMPOUNDS WITH HIGH AFFINITY, SUFFICIENT SELECTIVITY, CHARACTERIZED AGONIST-ANTAGONIST RESPONSES, AND/OR SUITABLE IN VIVO ACTIVITY. CURRENTLY THERE ARE NO KNOWN COMPOUNDS WITH DIFFERENTIAL ACTIVITY AT D4R VARIANTS. THEREFORE, WE SEEK TO DEVELOP NEW, OPTIMIZED D4R LIGANDS WITH VARIANT-SPECIFIC ACTIVITY TO EXPAND OUR UNDERSTANDING OF D4R FUNCTION AND IN THE DEVELOPMENT OF POTENTIAL THERAPEUTIC COMPOUNDS. D4.7R HAS ALTERED ABILITY TO HETEROMERIZE WITH DOPAMINE D2 RECEPTORS (D2RS) OR A2A ADRENERGIC RECEPTORS (A2ARS), WHEN COMPARED TO THE MORE COMMON D4.4R. OUR TEAM HAS DISCOVERED THAT D4R AGONIST A-412997 PRODUCES DIFFERENTIAL SIGNALING AT D4.7R OR D4.4R HETEROMERIZED WITH D2R OR A2AR, AND DIFFERENTIAL SIGNALING AT GAI1 VERSUS GAO1. WE WILL LEVERAGE OUR EXISTING LIBRARY OF A-412997 ANALOGS, AND CREATE NEW RATIONALLY DESIGNED ANALOGS, TO IDENTIFY NEW PHARMACOLOGICAL TOOLS WILL HAVE THE POTENTIAL TO SURMOUNT CURRENT LIMITATIONS ON THE UNDERSTANDING OF THE FUNCTIONAL SIGNIFICANCE OF D4R VNTR POLYMORPHISMS. NOVEL D4R LIGANDS ALSO HOLD THE POTENTIAL TO BE USED AS PHARMACOTHERAPEUTICS FOR SUD. SINCE THERE ARE NO FDA-APPROVED MEDICATIONS FOR THE TREATMENT OF PSYCHOSTIMULANT USE DISORDERS, AND NO FDA-APPROVED MEDICATIONS SELECTIVE FOR D4R, NOVEL PHARMACOLOGICAL TOOLS TARGETING D4R VARIANTS CAN ADDRESS MULTIPLE NEEDS. THE PROPOSED RESEARCH SEEKS TO DESIGN, SYNTHESIZE, AND EVALUATE NEW LIGANDS USING COMPUTATIONAL MODELING APPROACHES THAT EXPLOIT UNDEREXPLORED REGIONS WITHIN THE D4R PROTEIN STRUCTURE TO DEVELOP SELECTIVE D4.2R, D4.4R, AND D4.7R LIGANDS.

PASTA PROBES: DEFINING THE ROLE OF THE PASTA KINASE STK1 IN S. AUREUS VIRULENCE GENE EXPRESSION USING A CHEMICAL BIOLOGY APPROACH

REAL-TIME OPTIMIZED BIOFEEDBACK UTILIZING SPORT TECHNIQUES (ROBUST)

ASPIRE: ACTIVITIES SUPPORTING PRINCIPAL INDUCTION AND RESIDENCY EDUCATION

LOW-EFFICACY DOPAMINE D4 RECEPTOR PARTIAL AGONISTS FOR COCAINE ADDICTION

EXPLORING THE IMPACT OF SUBSTELLAR OBJECTS ON LATE STELLAR EVOLUTION

MRI: ACQUISITION OF A 400 MHZ NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROMETER TO SUPPORT UNDERGRADUATE RESEARCH AT HIGH POINT UNIVERSITY

SEX DIFFERENCES IN ACL INJURY RISK FACTORS EMERGE DURING ADOLESCENT GROWTH

COLLABORATIVE RUI PROPOSAL: EFFECTS OF CONTRASTING CLOUD REGIMES ON PLANT CARBON/WATER RELATIONS AT TREELINE

RUI: DEVELOPMENT OF A BIOCOMPATIBLE VISIBLE-LIGHT-CATALYZED THIOL-ENE COUPLING REACTION TO STUDY REDOX ACTIVE DISULFIDE BONDS.

THE ROLE OF RITUAL IN THE DEVELOPMENT OF COMPLEX SOCIETY

EQUIPMENT: MRI: TRACK 1 ACQUISITION OF A MASKLESS PHOTOLITHOGRAPHY INSTRUMENT FOR UNDERGRADUATE RESEARCH AND TEACHING AT HIGH POINT UNIVERSITY -THIS MAJOR RESEARCH INSTRUMENTATION (MRI) AWARD IS FOR THE ACQUISITION OF A MASKLESS PHOTOLITHOGRAPHY TOOL FOR USE BY FACULTY AND UNDERGRADUATE RESEARCHERS IN THE DEPARTMENTS OF CHEMISTRY, PHYSICS AND ENGINEERING AT HIGH POINT UNIVERSITY (HPU) (NC) IN COLLABORATION WITH FACULTY AND UNDERGRADUATE RESEARCHERS FROM THE DEPARTMENT OF CHEMISTRY AT THE UNIVERSITY OF RICHMOND (VA), DEPARTMENT OF PHYSICS AT JAMES MADISON UNIVERSITY (VA) AND THE DEPARTMENT OF BIOLOGY AT THE UNIVERSITY OF VIRGINIA ALONG WITH OTHER REGIONAL UNDERGRADUATE INSTITUTIONAL PARTNERS. THE ABILITY TO RAPIDLY PROTOTYPE STRUCTURES AND DEVICES WITH DIMENSIONS SMALLER THAN A CELL IS A KEY ENABLING CAPABILITY FOR A VARIETY OF TECHNOLOGIES, AND THE TRAINING OF UNDERGRADUATE CHEMISTRY, PHYSICS AND ENGINEERING STUDENTS WILL HELP EXPAND THE PIPELINE OF FUTURE NANOTECHNOLOGISTS. MICROLITHOGRAPHY IS A CRITICAL PROCESSING STEP IN THE PRODUCTION OF INTEGRATED CIRCUITS AND DEVICES, AND DEVELOPING A TRAINED WORKFORCE IN NANOFABRICATION IS VITAL TO THE ECONOMIC AND NATIONAL SECURITY INTERESTS OF THE UNITED STATES. FINALLY, STRUCTURES CREATED USING THIS TOOL WILL BE USED IN CONJUNCTION WITH THE IMAGING LABORATORY AT HPU FOR SCIENTIFIC OUTREACH TO LOCAL SCHOOLS AND MUSEUMS IN THE PIEDMONT TRIAD REGION OF NORTH CAROLINA TO SPARK AN INTEREST IN THE NEXT GENERATION OF LEARNERS IN THE MICRO AND NANOSCOPIC WORLD. THIS INSTRUMENT WILL BE USED TO TRAIN UNDERGRADUATE STUDENTS HOW TO RAPIDLY PROTOTYPE MICRO- AND NANOSTRUCTURES USED IN CHEMICAL SENSING, OPTICS, NEUROSCIENCE STUDIES, SURFACE ENGINEERING AND BIOMEDICAL DEVICES. THIS MAJOR RESEARCH INSTRUMENTATION AWARD IS FOR THE ACQUISITION OF A DIRECT-WRITE MASKLESS PHOTOLITHOGRAPHY TOOL FOR USE BY FACULTY AND UNDERGRADUATE RESEARCHERS AT HIGH POINT UNIVERSITY IN COLLABORATION WITH FACULTY AND UNDERGRADUATE RESEARCHERS AT JAMES MADISON UNIVERSITY AND THE AND THE UNIVERSITY OF VIRGINIA. THIS LITHOGRAPHY TOOL WILL ENABLE THE RAPID PROTOTYPING OF MICROSTRUCTURES DOWN TO 0.6 ?M IN SUPPORT OF THE RESEARCHERS ON THE PROJECT TEAM AND WILL BE MADE AVAILABLE TO OTHER INVESTIGATORS AT REGIONAL PRIMARILY UNDERGRADUATE INSTITUTIONS (PUIS) THROUGH THE PRIMARILY UNDERGRADUATE NANOMATERIALS COOPERATIVE (PUNC) AS A RESOURCE TO HELP FURTHER DEVELOP THEIR MICROFABRICATION RESEARCH AND EDUCATIONAL PROJECTS. THIS PROJECT WILL DIRECTLY ENABLE THE RAPID PROTOTYPING OF MICROSTRUCTURES IN RESEARCH PROJECTS RANGING FROM POLYMER MATERIALS SCIENCE TO NEUROSCIENCE. SPECIFICALLY, THESE PROJECTS INCLUDE THE RAPID PROTOTYPING OF SILICONE-BASED MICROSTRUCTURES FOR MICROFLUIDIC APPLICATIONS AND BIOFILM PREVENTION, MICROCONTACT PRINTING (?-CP) OF SURFACES FOR GRAFTING-FROM CONDUCTIVE POLYMER SYNTHESIS, MICROFABRICATION OF SILICON-BASED PHOTODETECTORS, DESIGN AND PROTOTYPING OF NANOPARTICLE-ENHANCED CHEMICAL SENSING PLATFORMS, AND RAPID PROTOTYPING OF MICROFLUIDIC STRUCTURES FOR NEUROSCIENCE STUDIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

THE PURPOSE OF THIS GRANT IS TO IMPROVE FOOD SECURITY AND EDUCATIONAL ENGAGEMENT IN HIGH POINT, NORTH CAROLINA. TO DO THIS, HIGH POINT UNIVERSITY WILL PERFORM THE FOLLOWING HIGH-LEVEL ACTIVITIES: BUILDING THE CAPACITY OF THE FOOD CHAIN, INCREASING GARDEN FOOD PRODUCTION, IMPROVED STEAM EDUCATION, CONNECTING STUDENTS AND FAMILIES TO WRAPAROUND SERVICES AND EXPANDING AFTERSCHOOL OPTIONS. THIS WILL BENEFIT LOW-INCOME YOUTH, ADULTS AND COMMUNITIES. GENERAL EXPECTED OUTCOMES INCLUDE INCREASED ORGANIZATION EFFICIENCY, EFFECTIVENESS AND PROGRAM REACH, IMPROVED STUDENT ACADEMIC PERFORMANCE, AND INCREASED FOOD SECURITY.

THE LUNAR SURFACE PROPAGATION GRANT PROGRAM S GOAL IS TO FUND RESEARCH INTO MODELING THE PROPAGATION EFFECTS OF LUNAR ENVIRONMENTAL CONSIDERATIONS FOR RADIO WAVE PROPAGATION ON THE MOON.

THE DEVELOPMENT OF A STANDARDIZED ASSESSMENT FOR INTRODUCTORY PHYSICS COURSES

COLLABORATIVE RESEARCH: USING WEB DATA TO STUDY CONGRESSIONAL CAMPAIGNS AND REPRESENTATION

COLLABORATIVE RESEARCH: USING WEB DATA TO STUDY CAMPAIGNS AND REPRESENTATION

HERE WE PROPOSE BOTH 20S AND 2MIN CADENCE TESS OBSERVATIONS OF KNOWN BINARY AND PULSATING HOT SUBDWARF STARS VISIBLE IN CYCLE 3. WE HAVE ALSO IDENTIFIED A LARGE NUMBER OF CANDIDATE VARIABLE HOT SUBDWARFS FROM THEIR ANOMALOUSLY HIGH GAIA FLUX ERRORS

HIGH POINT UNIVERSITY'S MISSION IS TO DELIVER EDUCATIONAL EXPERIENCES THAT ENLIGHTEN, CHALLENGE, AND PREPARE STUDENTS TO LEAD LIVES OF SIGNIFICANCE IN COMPLEX GLOBAL COMMUNITIES. THE PROPOSED VISTA PROJECT ALIGNS WITH THE HEALTHY FUTURES AND EDUCATION CNCS FOCUS AREAS. THE VISTA PROJECT WILL SEEK TO IMPROVE FOOD SECURITY AND EDUCATIONAL ENGAGEMENT IN HIGH POINT, NC. THE VISTA PROJECT EXPECTS TO BENEFIT 480 PEOPLE BY ENGAGING 410 NEW VOLUNTEERS IN IMPROVED VOLUNTEER MANAGEMENT PRACTICES. EIGHT VISTA MEMBERS, PLUS ONE VISTA LEADER, WILL CONTRIBUTE TO THE GOALS OF THE PROJECT BY PERFORMING TASKS, LIKE BUILDING THE CAPACITY OF THE FOOD CHAIN, FROM GARDEN FOOD PRODUCTION, TO INCREASED FARMERS MARKETS AND CO-OPS, TO IMPROVED FOOD EDUCATION AND COOKING SKILLS, AND ALSO BY CONNECTING STUDENTS AND FAMILIES TO WRAP-AROUND SERVICES, PROVIDING EXPANDED AFTER-SCHOOL EDUCATIONAL OPTIONS, AND DEVELOPING PATHWAYS TO COLLEGE FOR FIRST GENERATION STUDENTS. THESE ACTIVITIES WILL OCCUR OVER THE COURSE OF ONE YEAR.

COLLABORATIVE RESEARCH: TOOTH WEAR AND DIET AMONG LIVING AND FOSSIL PRIMATES

RUI: COLLABORATIVE RESEARCH: CDS&E: A MODULAR MULTILAYER FRAMEWORK FOR REAL-TIME HYPERSPECTRAL IMAGE SEGMENTATION -THE ANALYSIS OF IMAGES HAS BEEN USED BY THE SCIENTIFIC COMMUNITY TO SOLVE CHALLENGING PROBLEMS AND TO GET INSIGHT INTO DIVERSE NATURAL, SOCIAL, AND TECHNICAL PHENOMENA. DIFFERENT TYPES OF IMAGES HAVE BEEN EMPLOYED IN VARIOUS AREAS OF STUDY. ONE EXAMPLE IS THE HYPERSPECTRAL IMAGES, WHICH HAVE HIGHER RESOLUTION WHEN COMPARED TO CONVENTIONAL CAMERA IMAGES. ANALYZING SUCH IMAGES HAS ITS CHALLENGES. FOR INSTANCE, IT IS COMPUTATIONALLY DEMANDING, AND TRADITIONAL METHODS HAVE SOME LIMITATIONS. THIS PROJECT PROVIDES AN EFFICIENT SOLUTION TO ANALYZE SUCH IMAGES, BY EXPLOITING HIGH-PERFORMANCE COMPUTING TOOLS AND MACHINE LEARNING TECHNIQUES. THE RESULTING METHODS ARE APPLIED TO IMAGE-BASED ATMOSPHERIC CLOUD DETECTION. THE PROJECT DEVELOPS A REAL TIME, MULTI-LAYER, AND MODULAR SEGMENTATION FRAMEWORK FOR HYPERSPECTRAL IMAGES. THE DEVELOPED FRAMEWORK AUTOMATICALLY IDENTIFIES VARIOUS REGIONS WITHIN A HYPERSPECTRAL IMAGE BY CLASSIFYING EACH PIXEL OF THE IMAGE AND ASSOCIATING THEM TO CLASS SEGMENTS. THE DEVELOPED SYSTEM IS MULTI-LAYER, WHERE EACH LAYER?S RESPONSIBILITY IS TO PERFORM AN OPERATION ON ITS INPUT, GENERATE REGION CLASSIFICATION DATA, AND PASS THE RESULTANT OUTPUT TO THE NEXT LAYER. IMPORTANTLY, EACH LAYER ANALYZES ITS INPUT FROM DISTINCT VIEWPOINTS, UTILIZING SPECTRAL AND SPATIAL DATA, RESULTING IN A MULTI-LAYER FRAMEWORK WHERE THE LAYERS COMPLEMENT EACH OTHER. ALSO, THIS PROJECT AIMS TO PROVIDE AN OPTIMIZED HIGH-PERFORMANCE (SPEED-UP AND ACCURACY) COMPUTATIONAL TOOL FOR REAL-TIME HYPERSPECTRAL IMAGE ANALYSIS. THIS IS ACHIEVED BY ADAPTING THE ALGORITHMS USED IN THE DIFFERENT PARTS OF THE MODEL FOR PARALLEL PROCESSING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

NEH ENDURING QUESTIONS COURSE ON CONCEPTIONS OF CONSCIENCE IN WESTERN PHILOSOPHY, RELIGION, AND HISTORY

HERE WE PROPOSE TESS PHOTOMETRY OF KNOWN AND CANDIDATE VARIABLE HOT SUBDWARF B (SDB) STARS WITH AN EMPHASIS ON ECLIPSING SYSTEMS WITH LOW-MASS COMPANIONS.

COLLABORATIVE RESEARCH: USING WEB DATA TO STUDY U.S. CONGRESSIONAL CAMPAIGNS AND REPRESENTATION

COLLABORATIVE RESEARCH: USING WEB DATA TO STUDY THE NATURE AND CONSEQUENCES OF U.S. CONGRESSIONAL CAMPAIGNS

THIS INNOVATIVE MUSICAL PROGRAM WILL BUILD AWARENESS OF CLIMATE ISSUES AND OCEAN STEWARDSHIP AMONG YOUNG PEOPLE IN MARSEILLE, NICE, AND MONACO WHILE HIGHLIGHTING AMERICAN COMMITMENT TO ADDRESSING COMMON ENVIRONMENTAL CHALLENGES.

A POLITICAL ECOLOGY OF VALUE: A COHORT-BASED ETHNOGRAPHY OF URBAN SOCIAL POLICY