Research Triangle Institute

GH/HIDN/ID 936-3100 AAD

HIGH TEMPERATURE SYNGAS CLEANUP TECHNOLOGY SCALE-UP AND DEMONSTRATION PROJECT

TO ADDRESS CHALLENGES AND GAPS, RTI¿S SUSTAIN TEAM HAS DESIGNED A CAPACITY STRENGTHENING FOR SUSTAINABILITY APPROACH FOR CEP-NTD ELEMENT 2. THROUGH SEVEN IMPLEMENTATION STRATEGIES, SUSTAIN WILL SUPPORT COUNTRIES TO ACCELERATE PROGRESS NOW; ADDRESS BARRIERS WITH INNOVATION; DOCUMENT AND SHARE SUCCESSES; IDENTIFY LONG-TERM CONTROL PLATFORMS; AND STRENGTHEN LOCAL CAPACITY FOR PLANNING, BUDGETING, AND DELIVERY SO THAT NTD PROGRAMS CAN CONTINUE WITH HIGH LEVELS OF EFFECTIVENESS. SUSTAIN EXPERTS AND COUNTRY TEAMS WILL TAILOR THIS CAPACITY STRENGTHENING APPROACH AND STRATEGIES THROUGH REGULAR COMMUNICATION WITH USAID¿S NTD STAFF AND MINISTRIES OF HEALTH (MOHS). DATA AND CONTEXT WILL BE INCREASINGLY IMPORTANT AT THE COUNTRY LEVEL AS ELIMINATION APPROACHES; COVERAGE CHALLENGES IN THE LAST ENDEMIC AREAS ARE UNIQUE, REQUIRING INNOVATIVE STRATEGIES BASED ON ACCURATE DATA IN A SPECIFIC CONTEXT.

DESCRIPTION:RESEARCH TRIANGLE INSTITUTE (RTI) WILL UTILIZE THE SUBSEQUENT AWARD TOTALING $95,000,000 IN EJ TCGM FUNDING TO SERVE AS ONE OF ELEVEN GRANTMAKER ORGANIZATIONS THAT ARE CHARGED WITH IMPLEMENTING THE PROGRAM. RTI WILL SERVE IN THE CAPACITY OF A NATIONAL GRANTMAKER (CENTRAL REGIONS) AS WELL AS THE PROVISION OF DIRECT ASSISTANCE TO REGIONS 4 AND REGION 7. RTI WILL IMPLEMENT AND DEPLOY FEDERAL FINANCIAL ASSISTANCE TO INSTILL RESILIENCE TO UNDERSERVED COMMUNITIES INCLUSIVE OF REGIONS 4, 5, 6 AND 7. THIS FUNDING IS THE LATTER HALF OF THE BIFURCATED AWARD THAT WILL BE USED FOR PASSTHROUGH GRANTMAKING ACTIVITIES AUTHORIZED UNDER CAA 138(B). THE RTI NATIONAL GRANTMAKER (CENTRAL REGIONS) WILL BE FUNDED BY THE INFLATION REDUCTION ACT (IRA) APPROPRIATIONS AT THE LEVEL TOTALING $120 MILLION AND DIVIDED INTO TWO AWARDS. THE INITIAL AWARD OF $25 MILLION WAS MADE IN AUGUST 2024 AND THE SUBSEQUENT AWARD OF $95 MILLION IS SLATED FOR DECEMBER 2024. THE BIFURCATED AWARD IS SOURCED FROM THE SAME FUNDING BUT WILL MAINTAIN SEPARATE BUT OVERLAPPING TIMELINES TO MEET THE OVERALL COMPONENTS OF THE AWARD. THE SUBSEQUENT AWARD INCLUDES AWARD COMPETITION, SELECTION AND DISTRIBUTION OF FUNDS, CAPACITY BUILDING AND TECHNICAL ASSISTANCE FOR REGIONAL GRANTMAKERS AND SUBRECIPIENTS, PARTICIPATORY GOVERNANCE AND OUTREACH EFFORTS THAT WILL SUPPORT THE REGIONAL GRANTMAKERS IN 4,5,6, AND 7 AS WELL AS ADDRESSING COVERAGE GAPS THAT THEY MAY HAVE DIFFICULTY REACHING. GAPS INCLUDE, BUT IS NOT LIMITED TO, REMOTE AND/OR RURAL AREAS OF THE U.S. TERRITORIES AND PARTS OF THE CONTIGUOUS UNITED STATES. OEJECR HAS ALSO PROVIDED ADDITIONAL WITHIN-SCOPE SUPPLEMENTAL FUNDING FOR EACH GRANTMAKER TO ADDRESS QUALITY ASSURANCE (QA), HUMAN SUBJECTS REVIEW (HSR), AS WELL AS PROVIDE FUNDING FOR ADDITIONAL MEANINGFUL OUTREACH AND GAP FILLING TO REMOTE, RURAL AND HARD-TO-REACH AREAS OF THE COUNTRY, AND TERRITORIES THAT MUST BE ADJUSTED DUE TO ELEVATED TRAVEL COSTS. SUPPLEMENTAL FUNDS TOTAL $20M OF THE $95 MILLION AND WILL BE USED TO SUPPORT THE SUCCESSFUL DISTRIBUTION AND COMPLETION PROJECTS FUNDED UNDER THE SUBAWARDS. IT SHOULD BE NOTED THAT THE INITIAL AWARD ENABLED THE GRANTMAKER TO PERFORM THE TASKS NEEDED TO PLAN AND IMPLEMENT PROPOSED PARTICIPATORY GOVERNANCE, OUTREACH, AND SYSTEM MOBILIZATION EFFORTS THAT ESTABLISHED THE CRITERIA FOR THE COLLECTION, REVIEW, SELECTION, AND DISTRIBUTION OF THE EJ THRIVING COMMUNITIES SUBAWARDS. THE PASS-THROUGH MODEL DEVELOPED BY EPA IS CENTRAL TO THE NEW APPROACH, AS IT ALLOWS THE GRANTMAKERS TO DISTRIBUTE SMALLER SUBAWARDS TO COMMUNITY-BASED ORGANIZATIONS (CBOS) MORE EFFICIENTLY THAN THE TRADITIONAL FEDERAL GRANTS PROCESS. THIS MODEL WILL ENDEAVOR TO ENSURE THAT UNDERSERVED COMMUNITIES CAN ACCESS FUNDS MORE QUICKLY AND WITH FEWER ADMINISTRATIVE BURDENS. THE WORK PREVIOUSLY CONDUCTED UNDER THE ENVIRONMENTAL JUSTICE SMALL GRANTS PROGRAM WILL BE MANAGED BY GRANTMAKERS WHILE ALLOWING EPA TO FOCUS ON ASSESSMENT, PLANNING, AND PROJECT DEVELOPMENT. RTI HAS EXTENSIVE EXPERIENCE IN GRANTMAKING AND PROVIDING TECHNICAL SUPPORT FOR EQUITY-CENTERED APPROACHES THAT BUILD COLLABORATIVE ENVIRONMENTALLY BASED OUTCOMES AND WILL ENDEAVOR TO ENSURE THAT EPA FUNDS UNDER THE THRIVING COMMUNITY GRANTMAKER PROGRAM ARE MANAGED AND DISTRIBUTED TO COMMUNITIES THAT ARE MOST IN NEED OF ADDRESSING HEALTH AND ENVIRONMENTAL CHALLENGES. BY INCREASING FUNDING ACCESS AND REDUCING ADMINISTRATIVE BARRIERS, THE EPA AIMS TO EMPOWER DISADVANTAGED COMMUNITIES TO ADDRESS LONG-STANDING ENVIRONMENTAL JUSTICE CHALLENGES. THIS APPROACH ALIGNS WITH THE GOALS OF EXECUTIVE ORDERS 13985 AND 14008, WHICH PRIORITIZE EQUITABLE ACCESS TO FEDERAL RESOURCES AND EMPHASIZES THE NEED FOR INCLUSIVE DECISION-MAKING PROCESSES THAT ADVANCE ENVIRONMENTAL JUSTICE NATIONWIDE. ACTIVITIES:AS IT RELATES TO EPA REGION 4, RTI WILL PARTNER WITH THE SOUTHERN ENVIRONMENTAL LAW CENTER (SELC), NATIONAL CENTER FOR HEALTHY HOUSING, INTERNATIONAL CITY/COUNTY HOUSING, INTERNATIONAL CITY/COUNTY MAN

THIS IS A FIVE YEARS COOPERATIVE AGREEMENTWITH A TOTAL ESTIMATED COST OF $129,828,192

DEFENSE SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) EDUCATION CONSORTIUM

THE PURPOSE OF THIS MODIFICATION IS TO 1) PROVIDE INCREMENTAL FUNDING IN THE AMOUNT OF $14,850,000.00, INCREASING THE AMOUNT OBLIGATED FROM $13,000,0

DATA COORDINATING CENTER FOR THE NICHD NEONATAL RESEARCH NETWORK (U24)

USAID EARLY GRADE READING AND MATH PROJECT

KENYA FEED THE FUTURE CROPS AND DAIRY MARKET SYSTEMS DEVELOPMENT ACTIVITY

UGANDA LITERACY AND HEALTH EDUCATION PROGRAM

THE PURPOSE OF THIS AWARD IS TO PROVIDE SUPPORT FOR A 5-YEAR PROGRAM ENTITLED "FAMILY PLANNING/MATERNAL & NEONATAL HEALTH INNOVATIONS AND CAPACITY BUILDING PLATFORM (REACHHEALTH)."

QUALITY INSTRUCTION TOWARDS BASIC EDUCATION IMPROVEMENT AND ACCESS 3 ACTIVITY (QITABI 3)

READING FOR ETHIOPIA''S ACHIEVEMENT DEVELOPED (READ) TECHNICAL ASSISTANCE

DATA COORDINATING CENTER FOR THE NICHD COOPERATIVE MULTICENTER NEONATAL RESEARCH

IDH WILL SUPPORT THE IMPLEMENTATION OF COMPREHENSIVE HEALTH PLANS AT THE DISTRICT LEVEL THAT ADDRESS THE KEY DRIVERS OF MALARIA, MATERNAL, NEONATAL, AND CHILD MORBIDITY AND MORTALITY IN FIVE PRIORITY REGIONS OF SENEGAL TO IMPROVE THE HEALTH STATUS OF THE TARGET POPULATIONS. THE ACTIVITY COMBINES TECHNICAL ASSISTANCE FOR SERVICE DELIVERY AND UNIVERSAL HEALTH COVERAGE, SOCIAL AND BEHAVIOR CHANGE, SUBGRANT FUNDING AND HEALTH SYSTEMS STRENGTHENING INTO ONE MECHANISM.

NEW COOPERATIVE AGREEMENT AWARD TO RTI

THE ABC+ ADVANCING BASIC EDUCATION IN THE PHILIPPINES (ABC+) PROJECT IS A FIVE-YEAR, $38.5 MILLION PROJECT TO IMPROVE BASIC LIFE SKILLS FOR CHILDREN IN THE EARLY GRADES THROUGHOUT THE PHILIPPINES. THIS INCLUDES THE ABILITY TO READ AND DO MATH, AND TO APPLY OTHER BASIC LIFE SKILLS. TO ACHIEVE ITS GOAL, THE PROJECT IS PURSUING AN INTEGRATED APPROACH TO ABC+'S THREE INTERMEDIATE RESULTS (IRS). IMPROVED INSTRUCTION AND LEARNING DELIVERY (IR1) WILL INVEST IN PROFESSIONAL DEVELOPMENT AND SUPPORT FOR TEACHERS. TO IMPROVE ACCESS TO QUALITY MATERIALS (IR2), THE PROJECT WILL INTRODUCE INNOVATIVE APPROACHES TO MATERIALS DEVELOPMENT AND BUILD CAPACITY TO DEVELOP AND MAKE AVAILABLE MATERIALS IN A VARIETY OF LANGUAGES. TO ENSURE THAT ABC+-INTRODUCED IMPROVEMENTS CAN REACH ALL SCHOOLS IN THE TARGET REGIONS AND BE SUSTAINED (IR3), THE PROJECT WILL BUILD SYSTEM CAPACITY AND DEPED COMMITMENT TO PLAN, MOBILIZE, AND MANAGE PUBLIC AND PRIVATE RESOURCES AND TO SUPPORT IMPROVED EARLY GRADE LEARNING.

TO IMPROVE THE READING SKILLS OF PRIMARY-GRADE LEARNERS IN GOVERNMENT SCHOOLS IN UGANDA THROUGH THE SCALE UP OF THE EGR METHODOLOGY

GUINEA MALARIA BILATERAL AWARD

SCIENCE TECHNOLOGY RESEARCH INNOVATION FOR DEVELOPMENT (STRIDE)

IGF::CL::IGF USAID/RENFORCEMENT DE LA LITTÉRATIE AU SENEGAL (RELIS). TO IMPROVE STUDENTS’ READING OUTCOMES IN KINDERGARTEN (KG) THROUGH SECOND GRADES IN NINE REGIONS OF SENEGAL.

KINERJA (LOCAL GOVERNANCE PROGRAM)

NEW CO-OPERATIVE AGREEMENT DSEC

GUINEA LOCAL HEALTH SYSTEMS STRENGTHENING (GLHSS) ACTIVITY WILL CONTRIBUTE TO SELF-RELIANCE AND SUSTAINABILITY BY BUILDING THE CAPACITY AND COMMITMENT OF COMMUNITY HEALTH COMMITTEES TO COLLABORATE PRODUCTIVELY WITH THEIR STRENGTHENED LOCAL PUBLIC HEALTH FACILITIES. ENGENDERING GREATER TRUST OF LOCAL COMMUNITIES IN THE PUBLIC HEALTH SYSTEM WOULD RESULT IN STRONGER PARTICIPATION IN THE MANAGEMENT AND GOVERNANCE OF THE HEALTH SECTOR. INCREASED CAPACITY AND COMMITMENT OF COMMUNITY MEMBERS AND HEALTH FACILITY STAFF WOULD SUSTAIN GLHSS GAINS BEYOND THE LIFE OF THE ACTIVITY.

THE FOOD FOR PROGRESS PROGRAM PROVIDES FOR THE DONATION OF U.S. COMMODITIES TO DEVELOPING COUNTRIES AND EMERGING DEMOCRACIES THAT ARE COMMITTED TO INTRODUCING OR EXPANDING FREE ENTERPRISE IN THEIR AGRICULTURAL ECONOMIES. THE PROGRAM HAS TWO PRIMARY STRATEGIC OBJECTIVES: (1) INCREASE AGRICULTURAL PRODUCTIVITY AND (2) EXPAND TRADE OF AGRICULTURAL PRODUCTS.

PELVIC FLOOR DISORDERS NETWORK DATA COORDINATING CENTER: (2016-2021)

HEALING COMMUNITIES STUDY DATA COORDINATING CENTER

THE IPE ACTIVITY WILL INCREASE ACCESS TO SAFE, QUALITY BASIC EDUCATION FOR CHILDREN AND YOUTH BY IMPROVING SOCIO- ECONOMIC OPPORTUNITIES, CONTRIBUTING TO THE MULTI-SECTORAL IMPACTS OF VIOLENCE PREVENTION EFFORTS, AND DECREASING IRREGULAR MIGRATION.

USAID/UGANDA BIODIVERSITY FOR RESILIENCE ACTIVITY

NUTRITION FOR PRECISION HEALTH, POWERED BY THE ALL OF US RESEARCH PROGRAM: RESEARCH COORDINATING CENTER - CONTACT PD/PI: GANTZ, MARIE G. PROJECT SUMMARY/ABSTRACT FROM PROPOSAL: THE OVERARCHING GOAL OF THE RTI INTERNATIONAL–CORNELL RESEARCH COORDINATING CENTER (RCC) IS TO PROVIDE SEAMLESS OPERATIONAL SUPPORT AND MULTIDISCIPLINARY EXPERIENCE FOR BUILDING CONSENSUS IN THE NUTRITION FOR PRECISION HEALTH CONSORTIUM (NPHC). IN THE 1-YEAR PLANNING PHASE, WE WILL PRIORITIZE EFFICIENCY AND OBJECTIVITY IN FACILITATING THE DESIGN OF DIET MODULES (1: USUAL DIETARY ASSESSMENT; 2: CONTROLLED FEEDING DIETARY INTERVENTION; AND 3: DOMICILED DIETARY INTERVENTION) NESTED IN ALL OF US AND THEIR RESEARCH PROTOCOLS. IN THE 4-YEAR IMPLEMENTATION PHASE, WE WILL FACILITATE THE IMPLEMENTATION OF MODULES 1–3, ENABLE THE FLOW OF QUALITY DATA AND SPECIMENS ACROSS THE NPHC, AND INTEGRATE CURATED, ARTIFICIAL INTELLIGENCE (AI)–READY DATA INTO THE ALL OF US RESEARCHER WORKBENCH, USING OUR ESTABLISHED DATA COORDINATION PROCESSES AND SYSTEMS. INNOVATIONS IN OUR APPROACH INCLUDE TOOLS FOR CONDUCTING DIETARY STUDIES IN HARD-TO-REACH POPULATIONS, IDIOGRAPHIC (OR SUBJECT-AS-OWN-CONTROL) CLINICAL TRIALS, AND WEARABLES RESEARCH TOOLS AND ANALYTICS. SPECIFICALLY, THE PROPOSED RCC WILL EXCEL IN ADMINISTRATING AND COORDINATING NPHC AND ITS RESEARCH INITIATIVES, CLINICAL INTERVENTIONS, AND DATA AND BIOSPECIMEN SHARING, AS FOLLOWS: AIM 1: OPTIMIZE THE SCIENTIFIC RIGOR OF MODULES 1–3 AIM 2: ENSURE NPHC STUDY DATA ARE FAIR (FINDABLE, ACCESSIBLE, INTEROPERABLE, AND REUSABLE) AIM 3: ENABLE SEAMLESS DATA COLLECTION, CURATION, AND TRANSFER INCLUDING TO THE RESEARCHER WORKBENCH AIM 4: MINIMIZE TIME TO LAUNCH OF MODULES 1–3 AIM 5: MAXIMIZE THE EFFICIENCY OF CONSORTIUM COMMUNICATIONS AND COLLABORATIONS NPHC IS BEING LAUNCHED TO ADDRESS MAJOR RESEARCH GAPS IN NUTRITION; THE NATURE OF THESE GAPS AND THE COMPLEXITY OF THE NPHC ACTIVITIES CANNOT BE UNDERSCORED ENOUGH. RCC WILL BE LED BY MULTIPLE PRINCIPAL INVESTIGATORS WITH COMPLEMENTARY EXPERTISE IN COORDINATING CENTER AND MULTISITE LEADERSHIP AND BIOSTATISTICS (DR. GANTZ AT RTI) AND NUTRITIONAL INTERVENTION AND CLINICAL EXPERTISE (DR. MEHTA AT CORNELL UNIVERSITY) WITH THE SUPPORT OF A STRONG AND DIVERSE TEAM, ORGANIZED AROUND CORES FOR DESIGN AND ANALYTICS, DATA CURATION AND SYSTEMS, AND STUDY IMPLEMENTATION. OTHER KEY COMPONENTS INCLUDE SINGLE IRB AND MEDICAL SAFETY MONITORING. THE RCC WILL ALSO BENEFIT FROM OUR COLLECTIVE INSTITUTIONAL STRENGTHS, WITH AN EXPERT POOL OF WIDE- RANGING RESEARCH AND CLINICAL BACKGROUNDS PERTINENT TO THE NPHC (E.G., OMICS, BIOINFORMATICS, AI, CLINICAL TRIAL INTERVENTION, NUTRITIONAL ASSESSMENT). THE PROPOSED RCC IS IMMEDIATELY AND AMPLY PREPARED TO SUPPORT TO NPHC IN ITS MISSION TO DEVELOP CLINICALLY MEANINGFUL ALGORITHMS THAT PREDICT INDIVIDUAL RESPONSES TO FOOD AND DIETARY PATTERNS AND TO IMPROVE HEALTH ACROSS DIVERSE U.S. POPULATIONS. PROJECT ABSTRACT

PHILIPPINES HEALTHGOV2 LUZON

THE PRIMARY GOAL OF THE UZBEKISTAN EDUCATION REFORM IS TO DEVELOP, TEST, IMPLEMENT, AND EVALUATE EFFECTIVE AND SCALABLE EDUCATION REFORMS THAT IMPROVE LEARNING OUTCOMES FOR UZBEK STUDENTS THROUGHOUT THE COUNTRY.

TO ADVANCE DEMOCRATIC GOVERNANCE IN GUINEA THROUGH MULTI-SECTORAL INTERVENTIONS BY IMPROVING GOVERNANCE IN THE HEALTH, THE EDUCATION AND THE AGRICULT

MENTAL AND SUBSTANCE USE DISORDERS PREVALENCE STUDY

PHILIPPINES SUSTAINABLE INTERVENTIONS FOR BIODIVERSITY, OCEANS, AND LANDSCAPES (SIBOL) ACTIVITY

DESCRIPTION:THE PURPOSE OF THE ENVIRONMENTAL PROTECTION AGENCY'S (EPA) THRIVING COMMUNITIES GRANTMAKING PROGRAM ( EJ TCGM ) IS TO TRANSFORM DISADVANTAGED AND UNDERSERVED COMMUNITIES INTO HEALTHY, THRIVING PLACES THAT CAN ADDRESS THE HEALTH AND ENVIRONMENTAL CHALLENGES THEY FACE NOW AND INTO THE FUTURE. EPA WILL DO THIS BY USING A PASS-THROUGH MODEL TO DISTRIBUTE GRANT FUNDS TO COMMUNITIES VIA MULTIPLE GRANTMAKERS SERVING COMMUNITIES ACROSS THE NATION. RESEARCH TRIANGLE INSTITUTE (RTI) INTERNATIONAL HAS BEEN SELECTED TO SERVE AS THE EPA REGION 4 AND NATIONAL-CENTRAL GRANTMAKER PROVIDING SUPPORT TO COMMUNITIES ACROSS EPA REGIONS 4-7, WITH A DEDICATED FOCUS ON EPA REGION 7. RTI'S DIVERSE TEAM BRINGS EXPERTISE IN GRANT MANAGEMENT, ENVIRONMENTAL SCIENCE, ENVIRONMENTAL JUSTICE, EQUITY#8208;CENTERED RESEARCH AND EVALUATION. RTI'S PROPOSED SOLUTION ADVANCES RACIAL EQUITY BY POSITIONING COMMUNITY MEMBERS, AS PART OF A COMMUNITY ADVISORY BOARD (CAB), AS DECISION MAKERS IN SELECTING SUB AWARDEES AND SUBGRANTEES. RTI'S PROCESS INCLUDES TARGETED OUTREACH AND RECRUITMENT STRATEGIES INCLUSIVE AND ACCESSIBLE TO POTENTIAL APPLICANTS IN VARIOUS MODALITIES, AND CULTURALLY APPROPRIATE TO REACH COMMUNITIES. RTI INTERNATIONAL WILL SUPPORT THE INFRASTRUCTURE TO QUICKLY LAUNCH AN APPLICATIONS INTAKE, REVIEW, AND AWARD PROCESS THAT IS SIGNIFICANTLY SIMPLIFIED FROM CURRENT FEDERAL GRANTS PROCESSES. RTI INTERNATIONAL WILL RECEIVE AN INITIAL AWARD OF $25,000,000 OF INFLATION REDUCTION ACT (IRA) FUNDING TO STAND-UP THE INFRASTRUCTURE TO SUPPORT COMMUNITIES DIRECTLY, AS WELL AS SUPPORT THE REGIONAL GRANTMAKERS IN THE CENTRAL REGIONS AND THE EJ TCGM NETWORK AS A WHOLE. ONCE THE INFRASTRUCTURE IS ESTABLISHED, RTI INTERNATIONAL WILL RECEIVE A SUBSEQUENT AWARD OF $75,000,000 TO IMPLEMENT SUBGRANTING PROGRAMS IN EPA REGIONS 4 AND EPA REGIONS 7, AS WELL AS TO PROVIDE SUPPORT TO THE EJ TCGM NETWORK AS A WHOLE. THIS BIFURCATED AWARDS PROCESS IS BEING IMPLEMENTED BY EPA TO ENSURE THAT THE GRANTMAKERS HAVE SUFFICIENT TIME TO ESTABLISH THE NECESSARY GRANTMAKING INFRASTRUCTURE BEFORE BEGINNING TO ISSUE SUBGRANTS. THE EJ TCGM PROGRAM IS A KEY LEVER TO ADVANCE ENVIRONMENTAL JUSTICE AND IMPROVE PUBLIC HEALTH IN COMMUNITIES ACROSS THE CENTRAL REGIONS WHILE ENSURING THAT COMMUNITY MEMBERS CAN SHAPE THE PROCESS.ACTIVITIES:RTI INTERNATIONAL AND ITS PARTNERS WILL COME TOGETHER TO SERVE AS THE REGION 4 AND NATIONAL-CENTRAL GRANTMAKERS. ACTIVITIES TO BE PERFORMED DURING THIS PROJECT ARE: 1) RTI WILL WORK, IN CONSULTATION WITH EPA REGIONAL LEADERS AND COMMUNITY REPRESENTATIVES, TO IDENTIFY AND ENGAGE THREE (3) NEW STATUTORY PARTNERS LOCATED WITHIN REGION 7 TO ENSURE TCGM PROVIDES DIRECT SUPPORT TO COMMUNITIES WITHIN THE REGION. 2) RTI INTERNATIONAL WILL IMPLEMENT THE COMMUNITY-ENGAGED TRANSFORMATIVE GOVERNANCE MODEL TO SUPPORT THE TYPE OF DECISION-MAKING THAT ACKNOWLEDGES THAT COMMUNITY ORGANIZATIONS HAVE THE AUTHORITY TO DEFINE SUCCESS FOR THEIR PROJECTS, DECIDE ON THE TYPE OF INTERVENTIONS THEY MOST NEED, AND CONTRIBUTE TO THE GRANTMAKING PROCESS. THE COMMUNITY ADVISORY BOARDS (CABS) ARE THE CORNERSTONE OF THE PROGRAM. WHILE APPLICATIONS WILL BE ACCEPTED ON A ROLLING BASIS, CABS WILL MEET TO MAKE FUNDING DECISIONS ON A QUARTERLY BASIS. THEY ARE ALSO CHARGED WITH GUIDING THE PROGRAM IMPLEMENTATION WITHIN THE REGIONS. IN CONSULTATION WITH EPA REGIONAL LEADERS, TCGM PARTNERS, AND COMMUNITY MEMBER INPUT, RTI WILL DEVELOP SELECTION CRITERIA TO SELECT COMMUNITY ADVISORY BOARD (CAB) MEMBERS. RTI WILL WORK CLOSELY TO ENSURE THAT SELECTION FOR CAB MEMBERS CONSIDERS CONTEXTUAL EQUITY CONSIDERATIONS SO THAT THE TCGM PROGRAM CAN SERVE THOSE COMMUNITIES THAT IT IS INTENDED TO BENEFIT. 3) THE COMMUNICATIONS AND OUTREACH TEAM WILL DEVELOP OUTREACH STRATEGIES THAT INCLUDE BOTH DIRECT IN-PERSON OUTREACH AND INDIRECT COMMUNICATION CHANNELS FOR THE COMPLETE LIFE CYCLE OF THE GRANT PROGRAM. FOR REGION 4 AND REGION 7, THE COMMUNICATIONS AND OUTREACH TEAM WILL

SUPPORT USAID INTEGRATION STRATEGY FOR STRENGTHENING LOAL GOVT. TO IMPROVE BASIC SERVICES: HEALTH EDUCATION WASH AND FOOD SECURITY.

MULTI-SECTOR ALLIANCES PROGRAM

HEALTHGOV-LGU COMPONENT

ENHANCING GLOBAL HEALTH SECURITY: EXPANDING EFFORTS AND STRATEGIES TO PROTECT AND IMPROVE PUBLIC HEALTH IN THE DEMOCRATIC REPUBLIC OF THE CONGO (DRC)

DATA COORDINATING CENTER (DCC) FOR THE NEONATAL OPIOID WITHDRAWAL SYNDROME PHARMACOLOGICAL TREATMENTS COMPARATIVE EFFECTIVENESS TRIAL (NOWS PHACET) - PROJECT SUMMARY/ABSTRACT MAJOR KNOWLEDGE GAPS EXIST IN OPTIMIZING PHARMACOLOGIC TREATMENT FOR NEONATAL OPIOID WITHDRAWAL SYNDROME (NOWS), A PRESSING PUBLIC HEALTH ISSUE. RIGOROUS, HIGH QUALITY, RANDOMIZED TRIALS ARE URGENTLY NEEDED TO DEVELOP THE EVIDENCE BASE AND BEST PRACTICES FOR NEONATAL MEDICINE IN THIS AREA. IN RESPONSE, THE NICHD HEAL INITIATIVE NOWS PHARMACOLOGICAL TREATMENTS COMPARATIVE EFFECTIVENESS TRIAL (NOWS PHACET) CONSORTIUM WILL DESIGN AND IMPLEMENT A MULTI-CENTER, COMPARATIVE EFFECTIVENESS, RANDOMIZED CONTROLLED TRIAL (RCT) TO ASSESS THE OPTIMAL PHARMACOLOGICAL TREATMENT FOR NOWS THAT INFORMS CLINICAL PRACTICE GUIDELINES. THERE IS A CRUCIAL NEED FOR AN INDEPENDENT AND EXPERIENCED DATA COORDINATING CENTER (DCC) TO PROVIDE HIGH-QUALITY AND IMPARTIAL BIOSTATISTICAL EXPERTISE TO ADDRESS THE SUBSTANTIAL METHODOLOGIC CHALLENGES IN THE DESIGN AND CONDUCT OF SUCH A TRIAL BY (1) BUILDING CONSENSUS TO HELP IDENTIFY CRITICAL METHODOLOGIC ISSUES; (2) BRINGING OBJECTIVE STATISTICAL EXPERTISE TO THE CONCEPTION, DESIGN, AND ANALYSES OF A RIGOROUS AND FEASIBLE RANDOMIZED TRIAL (WITH APPROPRIATE MONITORING); (3) DEVELOPING PROCESSES AND SYSTEMS TO INCREASE THE EFFICIENCY OF THE CONSORTIUM, ENSURE TRIAL FEASIBILITY, AND EFFECTIVE USE OF LIMITED TRIAL PARTICIPANTS AND RESOURCES; (4) ENSURING STANDARDIZATION OF STUDY DESIGN, DEVELOPMENT, DATA COLLECTION, DATA QUALITY, AND DATA ANALYSES WITH EXISTING HEAL ACTIVITIES; AND (5) DISSEMINATION OF STUDY RESULTS, PUBLIC REPORTS, AND PUBLIC USE DATA. AS LONGTIME DCC FOR THE NICHD NEONATAL RESEARCH NETWORK (NRN) AND THE ONGOING ADVANCING CLINICAL TRIALS IN NEONATAL OPIOID WITHDRAWAL (ACT NOW) STUDIES, RTI HAS SUCCESSFULLY COLLABORATED IN THE DESIGN AND IMPLEMENTATION OF 30+ RCTS IN NEONATES INFORMING CLINICAL PRACTICE. OUR SPECIFIC AIMS AS THE DCC FOR NOWS PHACET ARE TO (1) ENHANCE THE SCIENTIFIC RIGOR OF THE CONSORTIUM BY COLLABORATIVELY BUILDING CONSENSUS FOR A UNIFORM PROTOCOL THAT ADDRESSES THE UNIQUE FEASIBILITY AND IMPLEMENTATION CHALLENGES OF PHARMACOLOGICAL RCTS IN NOWS; (2) OPTIMIZE PRODUCTIVITY WITH FLEXIBLE, EFFICIENT, AND HIGH QUALITY DATA AND STUDY MANAGEMENT, AND PROMOTE HEAL DATA HARMONIZATION AND SHARING; (3) PROTECT PARTICIPANT SAFETY AND STUDY INTEGRITY WORKING WITH THE INDEPENDENT DATA SAFETY AND MONITORING COMMITTEE (DSMC), SINGLE IRB (SIRB), NICHD, AND FDA (AS NEEDED); (4) PROVIDE TIMELY REPORTING AND DATA ANALYSIS, AND COLLABORATE WITH INVESTIGATORS ON ALL CONSORTIUM ANALYSES AND PUBLICATIONS; AND (5) PROVIDE THE NECESSARY LOGISTICAL, CONTRACTUAL, COMMUNICATIONS, AND REGULATORY SUPPORT. THE UNIQUE STRENGTHS OF THIS APPLICATION INCLUDE (1) A HIGHLY QUALIFIED PI AND STAFF UNIQUELY EXPERIENCED IN ALL ASPECTS OF BOTH NEONATAL AND NOWS TRIALS INCLUDING NEURODEVELOPMENTAL FOLLOW-UP; (2) PROVEN TRACK RECORD OF COLLABORATION AND SCIENTIFIC PRODUCTIVITY IN PERINATAL STUDIES; (3) STATE-OF-THE-ART INFRASTRUCTURE OF FLEXIBLE TOOLS, PROCESSES, AND SYSTEMS CUSTOMIZED FOR NEONATAL/ NOWS RCTS INCORPORATING FOLLOW-UP; (4) MULTIDISCIPLINARY EXPERTS AVAILABLE AS NEEDED; AND (5) DEPTH AND BREADTH OF EXPERT STAFF WITH AN AGILE ADMINISTRATIVE STRUCTURE THAT CAN RESPOND QUICKLY TO CHANGING NEEDS.

EXCELLENCE IN HIGHER EDUCATION FOR LIBERIAN DEVELOPMENT (EHELD)

PRESIDENT''S MALARIA INITIATIVE PROGRAM

CRIME PREVENTION PROJECT

A NEW ONE YEAR COOPERATIVE AGREEMENT WITH A TEC OF 3,356,770 AND INITIAL OBLIGATION OF $2,812,000

CONTINUATION OF THE NUMOM2B HEART HEALTH STUDY

THE PURPOSE OF THE USAID/SENEGAL'S MILLENNIUM WATER AND SANITATION PROGRAM (USAID/PEPAM) DESCRIBED HEREIN IS TO IMPROVE SUSTAINABLE ACCESS TO WATER A

USAID/CAMBODIA INTEGRATED EARLY CHILDHOOD DEVELOPMENT (IECD) ACTIVITY

THE PURPOSE OF THIS AWARD IS TO PROVIDE ASSISTANCE FOR IMPLEMENTING THE AGRICULTURAL PRODUCTION COMPONENT OF THE MALI GLOBAL FOOD SECURITY STRATEGY FOR A SUSTAINABLE INTENSIFICATION OF TARGET VALUE CHAINS IN THE SIKASSO REGION.

GENOMIC RESOURCE GRANT FOR PHENX TOOLKIT (U41)

PELVIC FLOOR DISORDERS NETWORK DATA COORDINATING CENTER (U01)

USAID "UMUHIMU WA TAKWIMU ZA MALARIA" ACTIVITY¿S THEORY OF CHANGE STIPULATES THAT THE GOAL OF REDUCING MALARIA BURDEN AND MOVING MAINLAND TANZANIA AND ZANZIBAR TOWARD MALARIA ELIMINATION WILL BE ACHIEVED IF: (1) MALARIA SURVEILLANCE IS IMPROVED (RESULT 1); (2) ENTOMOLOGICAL MONITORING IS IMPROVED (RESULT 2); (3) DRUG EFFICACY MONITORING IS IMPROVED (RESULT 3); AND (4) GOT¿S EVIDENCE-BASED DECISION MAKING IS IMPROVED (RESULT 4) TO ACHIEVE THE ABOVE VISION, THE RECIPIENT¿S DESIGNED TECHNICAL APPROACH IS DIVIDED BY SIX GUIDING IMPLEMENTATION STRATEGIES THAT WILL ENABLE A SUCCESSFULLY EXECUTED USAID UMUHIMU WA TAKWIMU ZA MALARIA ACTIVITY SUSTAIN RESULTS THROUGH PROGRAMMATIC INTEGRATION, LOCAL OWNERSHIP, AND CAPACITY STRENGTHENING

PRETERM BIRTH IN NULLIPAROUS WOMEN: AN UNDERSTUDIED POPULATION AT GREAT RISK

FORENSIC TECHNOLOGY CENTER OF EXCELLENCE (FTCOE) FY17

GLOBAL NETWORK DATA COORDINATING CENTER

BASIC EDUCATION QUALITY AND TRANSITIONS ACTIVITY

FORENSIC SCIENCE TRAINING DEVELOPMENT AND DELIVERY PROGRAM

THE SHOBAI MILEY SHIKHI (“EVERYONE LEARNS TOGETHER”) ACTIVITY MAINLY AIMS TO IMPROVE LEARNING OUTCOMES FOR CHILDREN WITH DISABILITIES (CWD) IN BANGLADESH

2009 NATIONAL INMATE SURVEY

TO SUPPORT USAID/SENEGAL AND GOVERNMENT OF SENEGAL'S OBJECTIVE: BETTER EDUCATED YOUTH BY IMPROVING THE QUALITY OF BASIC EDUCATION FOR MIDDLE-SCHOOL A

IMPROVING CLINICAL AND PUBLIC HEALTH OUTCOMES THROUGH NATIONAL PARTNERSHIPS TO PREVENT AND CONTROL EMERGING AND RE-EMERGING INFECTIOUS DISEASE THREATS - SEE EVALUATION AND PERFORMANCE MGMT PLAN

GLOBAL NETWORK FOR WOMEN'S AND CHILDREN'S HEALTH RESEARCH DATA COORDINATING CENTER

ACHIEVING STUDENT CENTERED EDUCATION FOR A NEW TOMORROW (ASCENT)

THE CRIMINAL JUSTICE TESTING AND EVALUATION CENTER (CJTEC) PROVIDES RIGOROUS AND INDEPENDENT INFORMATION TO THE CRIMINAL JUSTICE COMMUNITY CONCERNING EMERGING TECHNOLOGIES AND PRACTICES IN LAW ENFORCEMENT, CORRECTIONS, COURTS, FORENSIC LABORATORIES, AND JUVENILE JUSTICE PROGRAMS. CJTEC WILL INFORM RESEARCH AND TECHNOLOGY ADOPTIONS BASED ON INPUT FROM PRACTITIONERS, STAKEHOLDERS, POLICYMAKERS, RESEARCHERS, AND INDUSTRY. WITH DIRECTION FROM THE NATIONAL INSTITUTE OF JUSTICE (NIJ), RTI INTERNATIONAL WILL PROVIDE OPERATIONAL OVERSIGHT AND TECHNICAL CAPACITY FOR THE CENTER WHICH WILL FOCUS ON FIVE PRIMARY TASKS: (1) CONDUCTING SECONDARY RESEARCH ON TECHNOLOGIES AND TECHNOLOGY IMPLEMENTATION FOR POTENTIAL USE BY CRIMINAL JUSTICE COMMUNITIES; (2) PERFORMING EXPERIMENTAL TESTING AND EVALUATION ON TECHNOLOGIES TO INFORM POTENTIAL ADOPTION; (3) CONDUCTING EXPERIMENTAL OR RIGOROUS QUASI-EXPERIMENTAL RESEARCH AND EVALUATION OF TECHNOLOGY IMPLEMENTATION; (4)ADMINISTERING THE NIJ COMPLIANCE TESTING PROGRAM; AND (5)SUPPORTING THE DEVELOPMENT, VALIDATION, AND MAINTENANCE OF CRIMINAL JUSTICE EQUIPMENT STANDARDS. CJTEC ACTS AS AN HONEST BROKER TO PROVIDE TECHNOLOGY AND IMPLEMENTATION INSIGHTS AND RIGOROUS RESEARCH, TESTING, AND EVALUATION TO EXAMINE SYSTEM PERFORMANCE, SAFETY, AND OPERATIONAL IMPACT WHILE ADDRESSING POTENTIAL UNINTENDED CONSEQUENCES OF PRACTITIONER ADOPTION IN REAL-WORLD SETTINGS. NCA/NCF

USAID DISASTER RISK MANAGEMENT (DRM) ACTIVITY

NEW AWARD TO RESEARCH TRIANGLE INSTITUTE UNDER REFUEL+IT FOA CONTROL NO: 2373-1502 TITLE: NEXT-GENERATION AMMONIA SYSTEM INTEGRATION UTILIZING INTERMITTENT RENEWABLE POWER RTI AND ITS PARTNERS PROPOSE TO DEVELOP A TECHNOLOGY INTEGRATION PLATFORM (TIP) TO DEMONSTRATE NEXT-GENERATION TECHNOLOGIES FOR AMMONIA (NH3) PRODUCTION AND UTILIZATION IN A MODULAR, LOAD-RESPONSIVE TESTBED AT 1 METRIC TON PER DAY SCALES FROM INTERMITTENT RENEWABLE ELECTRICITY.

ADMINISTRATIVE SUPPLEMENT FOR ACT NOW OBOE LONGITUDINAL STUDY

PREGNANCY AS A WINDOW TO FUTURE CARDIOVASCULAR HEALTH: ADVERSE PREGNANCY OUTCOMES

THE SEXUAL ASSAULT KIT INITIATIVE: NATIONAL TRAINING AND TECHNICAL ASSISTANCE

THE SEXUAL ASSAULT KIT INITIATIVE: NATIONAL TRAINING AND TECHNICAL ASSISTANCE PROGRAM

A THIN FILM POLYMER DEVICE (TFPD) THAT IS A SUBCUTANEOUSLY INJECTED AND BIODEGRADABLE.

BUILDING HEALTH DATA DISSEMINATION AND INFORMATION USE SYSTEMS IN THE REPUBLIC OF

HEAL INITIATIVE: COORDINATING CENTER TO SUPPORT NIDA PREVENTING OPIOID USE DISORDER IN OLDER ADOLESCENTS AND YOUNG ADULTS

DOD ALCOHOL AND SUBSTANCE ABUSE CONSORTIUM AWARD

ALCOHOL AND SUBSTANCE ABUSE DISORDERS RESEARCH PROGRAM CONSORTIUM AWARD

INTEGRATIVE OMICS CENTER FOR ACCELERATING NEUROBIOLOGICAL UNDERSTANDING OF OPIOID ADDICTION (ICAN) - PROJECT SUMMARY/ABSTRACT THE OVERARCHING GOAL OF THE INTEGRATIVE OMICS CENTER FOR ACCELERATING NEUROBIOLOGICAL UNDERSTANDING OF OPIOID ADDICTION (ICAN) IS TO IDENTIFY BIOLOGICALLY ACTIONABLE DRIVERS OF OPIOID ADDICTION (OA). WE WILL (1) CONDUCT LARGE-SCALE INTEGRATED MULTI-OMICS STUDIES OF OA IN HUMANS, (2) INTEGRATE RODENT–HUMAN STUDIES TO IDENTIFY GENES AND GENE NETWORKS IMPLICATED IN OA, AND (3) BUILD A PUBLICLY AVAILABLE NATIONAL OMICS RESOURCE FOR STUDYING OA. OUR COHERING PRINCIPLE IS THAT BY INTEGRATING MULTIPLE OMICS ACROSS HUMAN AND ANIMAL MODEL DATA WE WILL DISCOVER ROBUST DRIVERS OF INDIVIDUAL VARIATION THAT PREDISPOSE OPIOID USERS TO ADDICTION. THE OMICS REVOLUTION HAS DELIVERED MANY DISCOVERIES OF SUCH INDIVIDUAL VARIATION FOR COMPLEX DISEASES, INCLUDING FOR NICOTINE AND ALCOHOL PHENOTYPES, BUT NOT FOR OA. WE SEE FIVE FUNDAMENTAL CHALLENGES TO RAPID PROGRESS: (1) LIMITED SAMPLE SIZES AND UNACCOUNTED-FOR PHENOTYPIC HETEROGENEITY IN GENOME-WIDE ASSOCIATION STUDIES (GWAS) OF OA; (2) VERY LIMITED HUMAN BRAIN STUDIES OF GENE DYSREGULATION BY OA; (3) POOR TRANSLATION BETWEEN HUMAN AND ANIMAL MODEL STUDIES; (4) LACK OF CONCURRENT INTEGRATION OF MULTIPLE OMICS; AND (5) LIMITED PRACTICAL ACCESS TO, AND POOR HARMONIZATION OF, OA OMICS DATA. TO OVERCOME THESE CHALLENGES, ICAN HARNESSES FOUR PROJECTS AND TWO CORES: PROJECT 1: ELECTRONIC HEALTH RECORD PHENOTYPING AND GENOMICS OF OPIOID ADDICTION PROJECT 2: GENE REGULATION IN THE OPIOID DEPENDENT HUMAN BRAIN PROJECT 3: MULTI-SPECIES APPROACH TO OPIOID ADDICTION PROJECT 4: MULTI-OMICS GENE NETWORK IDENTIFICATION CORES: ADMINISTRATIVE CORE AND SYNERGY CORE ACROSS THESE PROJECTS AND CORES, WE WILL (1) CONDUCT THE LARGEST GWAS TO DATE (N>100,000 CASES) LEVERAGING GENOMIC STRUCTURAL EQUATION MODELING; (2) EXAMINE DIFFERENTIAL GENE REGULATION ACROSS KEY BRAIN REGIONS (PREFRONTAL CORTEX, NUCLEUS ACCUMBENS, AMYGDALA) IN THE LARGEST COLLECTION OF OA INFORMATIVE POSTMORTEM BRAINS TO DATE (N=641); (3) INTEGRATE RODENT AND HUMAN STUDIES USING GENEWEAVER.ORG, POLYGENIC TRANSCRIPTOME RISK SCORES, AND VARIANT FUNCTIONALIZING EXPERIMENTS; AND (4) APPLY EXPLAINABLE ARTIFICIAL INTELLIGENCE, GENE NETWORK MAPPING, AND MULTIPLE LINES-OF-EVIDENCE INTEGRATION FOR GENE NETWORK DISCOVERY. EACH PROJECT IS RIGOROUSLY DESIGNED TO MAKE NOVEL CONTRIBUTIONS. HOWEVER, BY INTEGRATING THE DIVERSITY OF ICAN’S SCIENCE THROUGH THE CROSS-FERTILIZATION AND COORDINATING EFFORTS OF THE CORES, WE WILL LEVERAGE THE AGNOSTIC DISCOVERY POWER OF OMICS AND PLACE IT WITHIN THE CONTEXT OF FUNCTIONAL NEUROBIOLOGY TO MAKE FIELD-CHANGING BREAKTHROUGHS AND IDENTIFY ACTIONABLE TARGETS FOR DEVELOPMENT OF OA TREATMENTS.

THE PURPOSE OF THIS ACTIVITY IS TO INCREASE ECONOMIC DEVELOPMENT AND FOOD SECURITY IN LIBERIA.

PHARMACOTHERAPIES FOR ALCOHOL AND SUBSTANCE USE DISORDER RESEARCH PROGRAM CONSORTIUM

NEW HIGHER EDUCATION ACTIVITY

CRIMINAL JUSTICE TESTING AND EVALUATION CONSORTIUM

MODELING OF INFECTIOUS DISEASE AGENT STUDY INFORMATION TECHNOLOGY

NATIONAL INMATE SURVEY (NIS-4) 2018-19

FY08 DRMRP CLINICAL TRIAL: STRENGTHENING PATHWAYS TO PTSD RECOVERY USING SYSTEMS-LEVEL INTERVENTION

NEW AWARD DE-FE0031590 WITH RESEARCH TRIANGLE INSTITUTE TITLED ENGINEERING SCALE TESTING OF TRANSFORMATIONAL NON-AQUEOUS SOLVENT-BASED CARBON DIOXIDE CAPTURE PROCESS AT TECHNOLOGY CENTRE MONGSTAD

WORKPLACE POLICIES AND PRACTICES COORDINATING CENTER

THE PURPOSE OF THIS REQUISITION IS TO SUPPORT THE GON IN THE SCALE-UP OF THE NATIONAL EARLY GRADE READING PROGRAM. THE LIFE OF THE ACTIVITY IS TWO YEARS I.E. JULY 2020 TO JULY 2022.

USAID'S STRENGTHENING LOCAL LEVEL HEALTH SYSTEM ACTIVITY

EMERGING INFECTIOUS DISEASES RESEARCH CENTERS COORDINATION CENTER (EIDRC CC)

EDUCATION SECTOR REFORM ASSISTANCE (ESRA)

DESCRIPTION:THIS ACTION PROVIDES FUNDING IN THE AMOUNT OF $4,000,000 FOR RESEARCH TRIANGLE INSTITUTE (RTI) TO PROVIDE MEANINGFUL ENGAGEMENT TO UNDERSERVED COMMUNITIES IN THE SOUTHEAST REGION OF THE UNITED STATES (REGION 4). THE ACTIVITIES TO BE PERFORMED UNDER THIS GRANT INCLUDE IDENTIFYING ENVIRONMENTAL AND ENERGY JUSTICE ISSUES, INCLUDING GEOGRAPHICAL ANALYSES USING GIS, AIR AND WATER QUALITY MONITORING, PERSONAL EXPOSURE ANALYSES, CLIMATE RESILIENCE ANALYSES, AND ENERGY POLICY IMPACT ASSESSMENTS. ADDITIONAL ACTIVITIES TO BE PERFORMED UNDER THIS GRANT ARE TO ASSIST PROGRAM PARTICIPANTS WITH NAVIGATING GOVERNMENT SYSTEMS, IDENTIFYING GRANT OPPORTUNITIES, APPLYING FOR GRANTS, AND MANAGING GRANTS. THE ANTICIPATED DELIVERABLES INCLUDE DOCUMENTATION FROM OUTREACH EFFORTS UNDERTAKEN, DESCRIPTIONS OF SERVICES PROVIDED, NUMBER OF PROGRAM PARTICIPANTS, TOOLS DEVELOPED, REPORTS ON FEEDBACK FROM PROGRAM PARTICIPANTS, PROGRAM EVALUATIONS, NUMBER OF IMPROVEMENTS MADE TO AN ENVIRONMENTAL JUSTICE THRIVING COMMUNITIES TECHNICAL ASSISTANCE CENTERS (EJ TCTAC), AND THE NUMBER OF CLEAN ENERGY DEMONSTRATION OPPORTUNITIES IDENTIFIED. THE EXPECTED OUTCOMES INCLUDE INCREASED AWARENESS, KNOWLEDGE AND UNDERSTANDING OF GRANT AMONG UNDERSERVED COMMUNITIES, INCREASED ACCESS TO GRANT WRITING AND MANAGEMENT RESOURCES, AND AN INCREASE TO THE NUMBER AND QUALITY OF APPLICATIONS FOR FUNDING RELATED TO ENVIRONMENTAL AND ENERGY JUSTICE FROM UNDERSERVED COMMUNITIES IN THE SOUTHEAST REGION. THE INTENDED BENEFICIARIES INCLUDE COMMUNITIES THROUGHOUT EACH OF THE REGION 4 STATES: (AL, FL, GA, KY, MS, NC, SC, TN). THE OUTCOMES OF THIS PROJECT WILL INCLUDE THE INCREASED GRANT WRITING CAPACITY, INCREASED COMMUNITY ENGAGEMENT, AND INCREASED PRODUCE YIELDED FROM THE GARDEN TO BENEFIT THE UNDERSERVED COMMUNITIES IN THE JACKSON, MISSISSIPPI AREA. ACTIVITIES:THE ACTIVITIES TO BE PERFORMED UNDER THIS GRANT INCLUDE IDENTIFYING ENVIRONMENTAL AND ENERGY JUSTICE ISSUES, INCLUDING GEOGRAPHICAL ANALYSES USING GIS, AIR AND WATER QUALITY MONITORING, PERSONAL EXPOSURE ANALYSES, CLIMATE RESILIENCE ANALYSES, AND ENERGY POLICY IMPACT ASSESSMENTS. ADDITIONAL ACTIVITIES TO BE PERFORMED UNDER THIS GRANT ARE TO ASSIST PROGRAM PARTICIPANTS WITH NAVIGATING GOVERNMENT SYSTEMS, IDENTIFYING GRANT OPPORTUNITIES, APPLYING FOR GRANTS, AND MANAGING GRANTS. RTI WILL FACILITATE COMMUNITY ENGAGEMENT AND PARTNERSHIP BUILDING TO ADDRESS ENVIRONMENTAL AND ENERGY JUSTICE ISSUES. RTI WILL PROVIDE TRANSLATION AND INTERPRETATION SERVICES WITH RESPECT TO GRANT PROGRAM AWARENESS AND APPLICATION, AWARD, AND MANAGEMENT PROCESSES TO PROVIDE PROGRAM PARTICIPANTS A MEANINGFUL OPPORTUNITY TO PARTICIPATE IN ENVIRONMENTAL AND ENERGY JUSTICE EFFORTS. RTI WILL FACILITATE FORMAL HANDS-ON TRAINING TO BUILD CAPACITY, INCLUDING STRENGTHENING HUMAN CAPITAL TO FOCUS ON ENVIRONMENTAL JUSTICE AND ENERGY JUSTICE ISSUES AND FOSTERING THIRD-PARTY 'COMMUNITY CHAMPIONS' (E.G., COMMUNITY ADVOCATES AND VOLUNTEER LEADERS) TO ENGAGE IN DECISION-MAKING PROCESS SO THEY WILL BE IN A STRENGTHENED POSITION TO PARTICIPATE IN ENVIRONMENTAL AND ENERGY JUSTICE PROGRAMS AND ADDRESS RELATED CHALLENGES. SUBRECIPIENT:THE SUB-AWARDEES WILL BE CONDUCTING CBO OUTREACH IN THEIR STATES, BEING THE PRIMARY CONDUIT FOR TECHNICAL ASSISTANCE IN THEIR RESPECTIVE STATE, AND PARTICIPATING IN REGION-WIDE TECHNICAL ASSISTANCE (TA) EVENTS.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE DOCUMENTATION FROM OUTREACH EFFORTS UNDERTAKEN, DESCRIPTIONS OF SERVICES PROVIDED, NUMBER OF PROGRAM PARTICIPANTS, TOOLS DEVELOPED, REPORTS ON FEEDBACK FROM PROGRAM PARTICIPANTS, PROGRAM EVALUATIONS, NUMBER OF IMPROVEMENTS MADE TO AN EJ TC TAC, AND THE NUMBER OF CLEAN ENERGY DEMONSTRATION OPPORTUNITIES IDENTIFIED. THE EXPECTED OUTCOMES INCLUDE INCREASED AWARENESS, KNOWLEDGE AND UNDERSTANDING OF GRANT AMONG UNDERSERVED COMMUNITIES, INCREASED ACCESS TO GRANT WRITING AND MANAGEMENT RESOURCES, AND AN INCREASE TO THE NUMBER AND QUALITY OF APPLICATIONS FOR FUNDING RELATED TO ENVI

ENHANCE PUBLIC SAFETY AND SECURITY IN THE TARGETED MUNICIPALITIES IN THE SIX CENTRAL REGION DEPARTMENTS OF: EI PROGRESO, ESCUINTLA JALAPA AND OTHERS

CHANGES IN LANGUAGE INCLUDED UNDER SECTION A.4 BUDGET AND IN THE PROGRAM DESCRIPTION

WITH THIS ACTIVITY, USAID SEEKS TO ADVANCE NUTRITION MONITORING, EVALUATION, RESEARCH, RESEARCH TRANSLATION, AND LEARNING TO IMPROVE THE NUTRITIONAL STATUS OF WOMEN AND CHILDREN. THE NEW ACTIVITY WILL FILL EVIDENCE GAPS TO IMPROVE NUTRITION OUTCOMES THROUGH HEALTH SYSTEMS WHILE ENSURING LOCAL PARTNERS DESIGN, IMPLEMENT, DISSEMINATE, AND USE SUCH EVIDENCE FOR POLICIES AND PROGRAMS.

DATA MANAGEMENT AND COORDINATING CENTER (DMCC) FOR THE MYALGIC ENCEPHALOMYELITIS/ CHRONIC FATIGUE SYNDROME (ME/CFS) COLLABORATIVE RESEARCH CENTERS (CRC)

SURVEY OF INMATES IN STATE AND FEDERAL CORRECTIONAL FACILITIES (SISFCF), 2012

BUILDING CONSENSUS FOR STANDARD MEASURES FOR GENOME-WIDE ASSOCIATION STUDIES

GLOBAL HEALTH SECURITY PARTNERSHIP ENGAGEMENT

TO PROVIDE SUPPORT FOR A PROGRAM IN COMMUNITY-BASED CRIME AND VIOLENCE PREVENTION.

FY 17 NATIONAL CRIME STATISTICS EXCHANGE (NCS-X-STATE) PROJECT: TECHNICAL ASSISTANCE AND IMPLEMENTATION SUPPORT

COORDINATING AND DATA SHARING CENTER - R&D OF VACCINES AND ANTIBODIES FOR PANDEMIC PREPAREDNESS (REVAMPP) - 0BPROJECT SUMMARY/ABSTRACT THE GLOBAL PANDEMIC CAUSED BY SARS-COV-2 HIGHLIGHTED THE CONTINUAL THREAT OF EMERGING AND RE-EMERGING PANDEMIC-POTENTIAL PATHOGENS AND THE CRITICAL VALUE OF COORDINATED MULTIDISCIPLINARY BASIC AND TRANSLATIONAL RESEARCH FOR PANDEMIC PREPAREDNESS. THERE IS AN URGENT NEED FOR AN INTEGRATED COLLABORATIVE EFFORT TO BUILD A ROBUST BASIC RESEARCH AND TRANSLATIONAL SCIENCE PORTFOLIO FOR PREPAREDNESS AGAINST HIGH-RISK VIRAL FAMILIES INCLUDING PARAMYXOVIRIDAE, PICORNAVIRIDAE, AND BUNYAVIRALES. THE NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) IS SUPPORTING THE DEVELOPMENT OF THE RESEARCH AND DEVELOPMENT OF VACCINES AND MONOCLONAL ANTIBODIES FOR PANDEMIC PREPAREDNESS (REVAMPP) NETWORK TO FILL THIS CRITICAL GAP. THE OVERALL GOAL OF THIS NEW COLLABORATIVE NETWORK, CONSISTING OF A COORDINATING AND DATA SHARING CENTER (CDSC) AND SIX TO EIGHT RESEARCH CENTERS, IS TO COLLABORATIVELY PRODUCE GENERALIZABLE KNOWLEDGE THAT ENABLES A RAPID RESPONSE WHEN PREVIOUSLY UNDERSTUDIED OR UNKNOWN PATHOGENS EMERGE. RTI INTERNATIONAL’S WELL-ESTABLISHED TRACK RECORD IMPLEMENTING LARGE-SCALE DOMESTIC AND INTERNATIONAL COORDINATING AND DATA MANAGEMENT CENTERS, INCLUDING IN THE EMERGING INFECTIOUS DISEASE ECOSYSTEM, MAKES US WELL QUALIFIED TO DEVELOP AND PROVIDE NETWORK GOVERNANCE, COMMUNICATIONS, AND DATA SHARING AND ANALYSIS AS THE REVAMPP CDSC. THE OVERALL GOAL OF THE RTI-BASED CDSC IS TO ESTABLISH AND MAINTAIN AN INTEGRATED NETWORK TO ACCELERATE DISCOVERY AND DISSEMINATION OF NOVEL VACCINE AND MONOCLONAL ANTIBODY STRATEGIES TO PREPARE FOR THE NEXT PANDEMIC OUTBREAK. TO ACCOMPLISH THIS GOAL, RTI PROPOSES A CDSC ORGANIZATIONAL STRUCTURE, CONSISTING OF TWO INTERCONNECTED TEAMS UNDER MPIS AND A PROJECT DIRECTOR—AN ADMINISTRATION AND LEADERSHIP TEAM, AND A DATA MANAGEMENT AND ANALYSIS TEAM. THIS STRUCTURE LEVERAGES RTI MULTIDISCIPLINARY EXPERTS AND WILL PROVIDE REVAMPP CENTERS, NIAID, AND STAKEHOLDERS CENTRALIZED ADMINISTRATIVE, COMMUNICATION, AND OPERATIONAL SUPPORT FOR NETWORK-WIDE ACTIVITIES, WHILE ALSO ESTABLISHING DATA SHARING AND ANALYSIS STANDARDS AND PLATFORMS. THE SPECIFIC AIMS OF THE RTI-BASED CDSC ALIGN WITH THESE TWO TEAMS AND WILL USE BOTH ESTABLISHED AND NOVEL INNOVATIVE APPROACHES AND TECHNOLOGIES TO (AIM 1) COORDINATE PREPARATORY VACCINE AND ANTIBODY STRATEGY RESEARCH BY ESTABLISHING AND MAINTAINING REVAMPP NETWORK GOVERNANCE, ADMINISTRATION, AND COMMUNICATION; AND (AIM 2) ACCELERATE TRANSPARENT COLLABORATIVE VACCINE AND ANTIBODY STRATEGY RESEARCH BY DEVELOPING AND MAINTAINING A SECURE REVAMPP NETWORK PRIVATE PORTAL THAT INCLUDES CENTRALIZED RESOURCE, DATA SHARING, AND REPORTING SYSTEMS. THIS INDEPENDENT, BUT INTEGRATED TEAM OF ADMINISTRATORS, COMMUNICATORS, AND DATA SCIENCE EXPERTS EMBEDDED WITHIN THE REVAMPP NETWORK AS THE CDSC, WILL COORDINATE, FACILITATE, AND EMPOWER NETWORK INVESTIGATORS AND NIAID TO PROACTIVELY PREPARE TO RAPIDLY SHARE INFORMATION WITH KEY STAKEHOLDERS ACROSS THE GLOBE WHEN NEW VIRAL PANDEMIC/OUTBREAKS OCCUR.

INCLUDE DOWN SYNDROME CLINICAL COHORT COORDINATING CENTER (DS-4C) - PROJECT SUMMARY/ABSTRACT THE OVERARCHING GOAL OF THE PROPOSED INCLUDE CLINICAL COHORT COORDINATING CENTER (DS-4C), CO-LED BY INVESTIGATORS AT RTI INTERNATIONAL AND EMORY UNIVERSITY, IS TO IMPROVE THE HEALTH AND WELL-BEING OF INDIVIDUALS WITH DOWN SYNDROME (DS) BY SUPPORTING THE INCLUDE PROJECT’S DS COHORT DEVELOPMENT PROGRAM (DS-CDP). IN THIS CAPACITY, THE DS-4C WILL SERVE AS THE CENTRAL HUB FOR ORCHESTRATING AND INTEGRATING ALL COMPONENTS OF THE DS-CDP, INCLUDING OVERSEEING THE DEVELOPMENT AND IMPLEMENTATION OF A COMMON PROTOCOL TO GUIDE HARMONIZED DATA COLLECTION ACROSS MULTIPLE DS COHORT RESEARCH SITES (DS-CRS) IN THE DS-CDP AND FACILITATING DATA TRANSFER INTO THE INCLUDE DATA COORDINATING CENTER (DCC) AND DATA HUB FOR AVAILABILITY TO RESEARCHERS. THE COMPLEX STRUCTURE OF THE DS-CDP REQUIRES THE DS-4C’S EXPERT LEADERSHIP AND COORDINATION TO GENERATE AN EFFECTIVE, INTEGRATED, UNIFIED NETWORK TO ACHIEVE THE GOAL OF GENERATING DEEP PHENOTYPING DATA AND COLLECTING BIOSPECIMENS IN A LARGE, DIVERSE COHORT OF INDIVIDUALS WITH DS ACROSS THE LIFESPAN TO SUPPORT FUTURE RESEARCH EFFORTS TO IMPROVE DS-ASSOCIATED CO-MORBIDITIES. THE FOUR CORES OF THE DS-4C (ADMINISTRATIVE, COHORT, OUTREACH, AND DATA MANAGEMENT) WILL LEVERAGE THE EXPERTISE OF CORE STAFF AND WORK COLLABORATIVELY TO PROVIDE ADMINISTRATIVE SUPPORT TO FACILITATE COLLABORATION AND COMMUNICATION ACROSS THE DS-CDP; ENSURE SEAMLESS IMPLEMENTATION OF THE PROTOCOL; IMPLEMENT AND SUPPORT INCLUSIVE OUTREACH EFFORTS TO FACILITATE INCLUSION AND REPRESENTATION IN RECRUITMENT; AND MANAGE THE FLOW OF DATA AND BIOSPECIMENS FROM THE DS-CRS TO THE INCLUDE DCC AND DATA HUB AND DS-BIOREPOSITORY, RESPECTIVELY. OUR SPECIFIC AIMS ARE AS FOLLOWS: AIM 1: IMPLEMENT TOOLS AND SYSTEMS TO FOSTER SEAMLESS INTEGRATION AND OPERATIONAL EFFICIENCY WITHIN THE DS-4C AND ACROSS THE DS-CDP. AIM 2: PROVIDE EXPERTISE AND RESOURCES TO DEVELOP AND IMPLEMENT THE COMMON PROTOCOL ACROSS THE DS-CDP WHILE ENHANCING THE SCIENTIFIC RIGOR OF DS-CRS STUDIES TO MAXIMIZE THE SCIENTIFIC IMPACT OF THE INCLUDE PROJECT. AIM 3: ENHANCE COMMUNITY ENGAGEMENT, FACILITATE RECRUITMENT OF PARTICIPANTS AND TEAM MEMBERS FROM TYPICALLY UNDERREPRESENTED GROUPS, ADVANCE HEALTH EQUITY GOALS, AND PROMOTE AWARENESS OF THE INCLUDE PROGRAM. AIM 4: MANAGE THE FLOW OF DATA FROM DS-CRS INTO THE INCLUDE DCC AND DATA HUB FOR ACCESS BY THE DS RESEARCH COMMUNITY. THE DS-4C WILL BE LED BY MULTIPLE PRINCIPAL INVESTIGATORS, DR. HUNTER AT RTI AND DR. ROSSER AT EMORY, WITH A COLLABORATIVE HISTORY AND EXTENSIVE EXPERTISE IN ELUCIDATING HEALTH OUTCOMES OF INDIVIDUALS WITH DS THROUGH PHENOTYPIC PROTOCOL DEVELOPMENT, BIOSPECIMEN COLLECTION, MULTI-SITE RECRUITMENT EFFORTS, AND DATA HARMONIZATION. THE PROPOSED DS-4C IS IMMEDIATELY AND AMPLY PREPARED TO SUPPORT ITS MISSION TO DEVELOP CLINICALLY MEANINGFUL FINDINGS THAT POSITIVELY IMPACT THOSE AFFECTED BY DS.

HUMAN HEALTH EXPOSURE ANALYSIS RESOURCE CORE: UNTARGETED ANALYSIS

EARLY CHECK: A COLLABORATIVE INNOVATION TO FACILITATE PRE-SYMPTOMATIC CLINICAL TRIALS IN NEWBORNS

TRANSFUSION-ASSOCIATED BRAIN IMPROVEMENT (TABI) TRIAL: DATA COORDINATING CENTER

ESTABLISHING THE PHENX TOOLKIT AS A BIOMEDICAL KNOWLEDGEBASE - PROJECT SUMMARY/ABSTRACT THE GOAL OF PHENX (CONSENSUS MEASURES FOR PHENOTYPES AND EXPOSURES) IS TO PROVIDE INVESTIGATORS WITH STANDARD MEASUREMENT PROTOCOLS (E.G., QUESTIONNAIRES, BIOASSAYS, PHYSICAL MEASUREMENTS) TO IMPROVE THE QUALITY AND CONSISTENCY OF DATA COLLECTION AND INCREASE THE IMPACT OF INDIVIDUAL STUDIES. OVER TIME, THIS COMMON CURRENCY WILL ENABLE INVESTIGATORS TO MORE EASILY COMBINE STUDIES TO INCREASE STATISTICAL POWER AND COMPARE STUDIES TO VALIDATE FINDINGS. ENABLING ANALYSIS OF SHARED DATA SHOULD LEAD TO A BETTER UNDERSTANDING OF THE ETIOLOGY, PROGRESSION, AND TREATMENT OF HUMAN DISEASE, ULTIMATELY LEADING TO IMPROVEMENTS IN PATIENT CARE, HEALTH OUTCOMES AND QUALITY OF LIFE. TO THIS END, PHENX HAS ESTABLISHED A FREELY AVAILABLE, WEB-BASED CATALOG (HTTPS://WWW.PHENXTOOLKIT.ORG/) OF MEASUREMENT PROTOCOLS INTENDED FOR USE IN GENOMIC, CLINICAL, TRANSLATIONAL, AND EPIDEMIOLOGICAL RESEARCH WITH HUMAN PARTICIPANTS. THE PHENX TOOLKIT CONTENT AND FEATURES ARE DRIVEN BY THE SCIENTIFIC COMMUNITY. THE PHENX STEERING COMMITTEE (SC) PROVIDES OVERARCHING GUIDANCE AND EACH MEASUREMENT PROTOCOL IN THE PHENX TOOLKIT IS SELECTED BY A WORKING GROUP (WG) OF EXPERTS USING A CONSENSUS-BASED PROCESS THAT RELIES ON INPUT FROM THE SCIENTIFIC COMMUNITY. INITIALLY RELEASED IN 2009, THE PHENX TOOLKIT CURRENTLY INCLUDES 874 PROTOCOLS ADDRESSING HUMAN PHENOTYPES AND EXPOSURES. IN THE NEXT 5 YEARS, PHENX WILL EXPAND THE BREADTH AND DEPTH OF THE TOOLKIT, INCREASE UTILITY, AND STRIVE TO INCREASE AWARENESS OF THE RESOURCE. THE SPECIFIC AIMS ARE TO (1) REVIEW, UPDATE, AND EXPAND PHENX TOOLKIT CONTENT; (2) LEVERAGE BIOMEDICAL STANDARDS TO INCREASE SCIENTIFIC IMPACT OF PHENX TOOLKIT; AND (3) RAISE AWARENESS AND INCREASE ADOPTION OF THE PHENX TOOLKIT. THIS RESEARCH PLAN WILL ESTABLISH THE PHENX TOOLKIT AS A SUSTAINABLE KNOWLEDGEBASE THAT ORGANIZES, ACCUMULATES, AND ANNOTATES STANDARD PROTOCOLS AND LINKS THEM TO RELEVANT RESOURCES AND DATA. THIS PLAN, WHICH REFLECTS A MULTIPRONGED APPROACH, WILL ENSURE THAT THE VALUE AND IMPACT OF THE PHENX TOOLKIT WILL CONTINUE TO INCREASE OVER TIME.

FY 2012 NATIONAL CRIME STATISTICS EXCHANGE (NCS-X) PROJECT: PHASE I

THE PURPOSE IS TO SUPPORT COMMUNITY POLICE. MODEL PRECINCT PROGRAM IN HONDURAS.

WARM SYNGAS CLEANUP OPERATIONAL TESTING AT TAMPA ELECTRIC COMPANY'S POLK 1 IGCC SITE

DESCRIPTION:THIS AGREEMENT PROVIDES FUNDING UNDER THE INFLATION REDUCTION ACT 9 (IRA) TO THE RESEARCH TRIANGLE INSTITUTE (RTI) IN THE AMOUNT OF $7,000,000 AS AUTHORIZED BY CAA 138(B). IN DECEMBER 2023, THE US ENVIRONMENTAL PROTECTION AGENCY'S (EPA) OFFICE OF ENVIRONMENTAL JUSTICE AND EXTERNAL CIVIL RIGHTS (OEJECR) SELECTED RESEARCH TRIANGLE INSTITUTE (RTI) TO RECEIVE $100 MILLION FROM THE $3 BILLION APPROPRIATION FROM THE INFLATION REDUCTION ACT (IRA) FOR THE ENVIRONMENTAL AND CLIMATE JUSTICE (ECJ) BLOCK GRANT PROGRAM UNDER CLEAN AIR ACT SECTION 138. THIS SELECTION IS A PART OF THE THRIVING COMMUNITIES GRANTMAKER PROGRAM (I.E. 'TCGM' OR 'GRANTMAKER'), WHERE RTI WILL USE $100 MILLION TO 1) MAKE SMALL SUBGRANTS TO ELIGIBLE ENTITIES THROUGH EPA REGIONS 4 - 7 THAT INCLUDE GRASSROOTS NONPROFIT ORGANIZATIONS AND TRIBAL AND LOCAL GOVERNMENTS AND 2) PROVIDE ADDITIONAL SUPPORT, COORDINATION, AND OVERSIGHT TO THE SUBGRANTEES, APPLICANTS, AND THE OTHER GRANTMAKERS. AS PART OF THE IRA LEGISLATION, OEJECR ALSO RECEIVED $200 MILLION TO PROVIDE TECHNICAL ASSISTANCE TO ELIGIBLE ENTITIES, AS DEFINED IN CAA SECTION 138, RELATED TO ANY GRANTS MADE FROM THE $3 BILLION APPROPRIATION. $20 MILLION OF THIS TECHNICAL ASSISTANCE IS BEING USED TO ESTABLISH AN INTERAGENCY AGREEMENT WITH AMERICORPS TO CREATE THE CLEAN ENVIRONMENT CORPS (CEC) VISTA PROGRAM. OF THIS $20 MILLION, $13 MILLION WILL BE SENT TO AMERICORPS VIA AN INTERAGENCY AGREEMENT AND $7 MILLION WILL BE DISTRIBUTED TO RTI AS A NONCOMPETITIVE AWARD ISSUED FOR THE PURPOSE OF SERVING AS THE INTERMEDIARY SPONSOR FOR ALL THE GRANTMAKERS. PROJECT ACTIVITIES DISCUSSED IN THIS FUNDING RECOMMENDATION WILL PRIMARILY FOCUS ON THOSE COVERED UNDER THE $7 MILLION NONCOMPETITIVE AWARD TO RTI. ACTIVITIES:VISTA MEMBERS WITH THE CEC ('CEC VISTA MEMBERS') PROGRAM WILL BE EMBEDDED WITH THE REGIONAL AND NATIONAL GRANTMAKERS TO PROVIDE TECHNICAL ASSISTANCE TO COMMUNITIES APPLYING FOR AND RECEIVING FUNDING THROUGH TCGM. THE AMERICORPS - TCGM PARTNERSHIP WILL SUPPORT APPROXIMATELY/UP TO 260 CEC VISTA MEMBERS AND APPROXIMATELY/UP TO 6 CEC VISTA LEADERS OVER A THREE-YEAR PERIOD. MEMBERS OF THE CEC VISTA PROGRAM WILL ALSO BE CONSIDERED MEMBERS OF THE AMERICAN CLIMATE CORPS, AN INITIATIVE TO PROVIDE AMERICANS WITH PATHWAYS TO HIGH-QUALITY, GOOD-PAYING CLEAN ENERGY AND CLIMATE RESILIENCE JOBS IN THE PUBLIC AND PRIVATE SECTORS AFTER THEY COMPLETE THEIR YEAR OF SERVICE. THE EPA AND AMERICORPS DECIDED THAT ONE NATIONAL GRANTMAKER WILL SERVE AS THE INTERMEDIARY SPONSOR RESPONSIBLE FOR MANAGING THE ENTIRE CEC PROGRAM ON BEHALF OF ALL THE GRANTMAKERS (BOTH REGIONAL AND NATIONAL). CENTRALIZING THE ADMINISTRATIVE RESPONSIBILITY FOR THE CEC PROGRAM WITH ONE NATIONAL GRANTMAKER, RATHER THAN USING ALL THREE NATIONAL GRANTMAKERS, CREATES ECONOMIES OF SCALE FOR RECRUITMENT AND REPORTING REQUIREMENTS AS WELL AS PROCESS STANDARDIZATION FOR THE ENTIRE PROGRAM. THE INTERMEDIARY SPONSOR WILL WORK WITH AMERICORPS, THE OTHER GRANTMAKERS, AND ANY PARTNERS TO THE GRANTMAKERS TO IMPLEMENT THE CEC PROGRAM. SECOND, THE INTERMEDIARY SPONSOR WILL APPLY TO AMERICORPS TO IMPLEMENT A VISTA PROJECT, THEREBY CREATING LESS ADMINISTRATIVE BURDEN FOR AMERICORPS. THIRD, THE INTERMEDIARY SPONSOR WILL RECRUIT, MANAGE, AND PLACE APPROXIMATELY/UP TO 260 CEC VISTA MEMBERS WITH 11 GRANTMAKERS AND THEIR PARTNERS. LASTLY, THE INTERMEDIARY SPONSOR WILL IDENTIFY PLACEMENTS FOR CEC VISTA MEMBERS AND ENTER INTO AGREEMENTS WITH GRANTMAKERS AND PARTNERS TO HOST THEM. ONCE THESE PLACEMENTS ARE IDENTIFIED, THE INTERMEDIARY SPONSOR WILL DESIGN AND IMPLEMENT A RECRUITMENT PROCESS FOR ALL CEC VISTA MEMBERS IN COORDINATION WITH AMERICORPS AND HOSTS. THE INTERMEDIARY SPONSOR WILL ALSO MANAGE THE PROGRAMMATIC, FINANCIAL, AND REPORTING REQUIREMENTS OF THE CEC PROGRAM ON BEHALF OF ALL OTHER HOSTS. RTI WILL ENSURE THAT ALL CEC VISTA MEMBERS AND LEADERS WILL PROVIDE TECHNICAL ASSISTANCE RELATED TO GRANTS FUNDED UN

PENNSYLVANIA: MULTI-SITE STUDY OF THE HEALTH IMPLICATIONS OF EXPOSURE TO PFAS-CONTAMINATED DRINKING WATER

OBSTETRICAL PHARMACOLOGY RESEARCH NETWORK - DATA COORDINATION AND ANALYSES CENTER

ANALYTIC RESOURCE CENTER

NATIONAL VICTIMIZATION STATISTICAL SUPPORT PROGRAM

THE DARBEPOETIN KINDERGARTEN DEVELOPMENT STUDY - PROJECT SUMMARY/ABSTRACT IMPROVED SURVIVAL OF VERY PRETERM INFANTS HAS NOT TRANSLATED INTO IMPROVED NEURODEVELOPMENT AT SCHOOL AGE. ONE PROMISING NEUROPROTECTIVE THERAPY IS THE USE OF ERYTHROPOIESIS STIMULATING AGENTS (ESAS) SUCH AS DARBEPOETIN. PRECLINICAL AND PRELIMINARY CLINICAL DATA SUGGEST THAT DARBEPOETIN TREATMENT WILL LEAD TO IMPROVED NEURODEVELOPMENTAL OUTCOMES IN HIGH-RISK PRETERM INFANTS. THE NHLBI-FUNDED “DARBEPOETIN TRIAL TO IMPROVE RED CELL MASS AND NEURODEVELOPMENT IN PRETERMS” (DARBE TRIAL) IS A MULTICENTER MASKED, RANDOMIZED TRIAL TO TEST THE HYPOTHESIS THAT DARBEPOETIN LEADS TO IMPROVED NEURODEVELOPMENT AT 2 YEARS IN VERY PRETERM INFANTS. IN THE CURRENT APPLICATION, WE PROPOSE THE DARBEPOETIN KINDERGARTEN DEVELOPMENT STUDY (DARBE-KIDS) IN WHICH WE WILL EVALUATE NEURODEVELOPMENT IN THE SAME CHILDREN AT PRESCHOOL AND SCHOOL AGE. THE SPECIFIC AIMS OF DARBE-KIDS ARE TO (1) TEST THE IMPACT OF NEONATAL EXPOSURE TO DARBEPOETIN ON NEURODEVELOPMENT AND BEHAVIOR AT 4.0-5.0 AND 6.0-7.0 YEARS CORRECTED AGE; (2) TEST THE IMPACT OF NEONATAL EXPOSURE TO DARBEPOETIN ON LONGITUDINAL NEURODEVELOPMENT AND BEHAVIOR FROM 2.0 TO 7.0 YEARS CORRECTED AGE; AND (3) EVALUATE MEDIATING AND MODERATING FACTORS ON THE EFFECTS OF DARBEPOETIN ON SCHOOL FUNCTIONING AT 6.0-7.0 YEARS CORRECTED AGE. WE HYPOTHESIZE THAT PRESCHOOL CHILDREN TREATED WITH DARBEPOETIN WILL HAVE BETTER COGNITIVE, MOTOR, AND BEHAVIOR OUTCOMES AT EACH TIME POINT AND OVER TIME, AS COMPARED TO THOSE TREATED WITH PLACEBO. FURTHER, WE HYPOTHESIZE THAT EXECUTIVE FUNCTION AND COGNITION WILL BE SIGNIFICANT MEDIATORS AND BIOLOGICAL SEX AND FAMILY SOCIOECONOMIC STATUS WILL BE SIGNIFICANT MODERATORS OF THE EFFECTS OF DARBEPOETIN ON PRE-ACADEMIC SKILLS AND TEACHER-REPORTED BEHAVIOR AND SOCIAL SKILLS. DARBE-KIDS BUILDS ON THE COLLECTIVE EXPERTISE IN FOLLOW-UP OF PRETERM INFANTS AMONG OUR CORE GROUP OF INVESTIGATORS AND AT THE 16 CLINICAL SITES THAT ENROLLED CHILDREN IN THE DARBE TRIAL AND CAPITALIZES ON THE EXISTING INFRASTRUCTURE THAT SUPPORTS BOTH THE DARBE TRIAL AND OTHER ONGOING SCHOOL-AGE STUDIES FUNDED BY NHLBI. THE STUDY IS LED BY A HIGHLY COLLABORATIVE, INTERDISCIPLINARY MULTI-PI TEAM WITH EXTENSIVE RELEVANT EXPERIENCE STUDYING THE IMPACTS OF ESAS IN PRETERM INFANTS AND A LONG HISTORY OF SUCCESSFUL COLLABORATIONS IN CONDUCTING HIGH-QUALITY DEVELOPMENTAL FOLLOW-UP THROUGH SCHOOL-AGE IN LARGE COHORTS OF HIGH-RISK INFANTS. DARBE-KIDS WILL BE THE FIRST COMPREHENSIVE EVALUATION OF DEVELOPMENTAL IMPACTS OVER TIME AND SCHOOL FUNCTIONING AT SCHOOL AGE IN A LARGE, MULTICENTER COHORT OF SCHOOL-AGE CHILDREN TREATED WITH DARBEPOETIN. IN ADDITION TO PROVIDING CRITICAL DATA ABOUT THE MULTIDIMENSIONAL EFFECTS OF DARBEPOETIN ON OUTCOMES THROUGH SCHOOL AGE, DARBE-KIDS WILL YIELD NOVEL AND IMPORTANT DATA ON SCHOOL FUNCTIONING IN A LARGE CONTEMPORARY COHORT OF PRETERM INFANTS TREATED IN U.S. NEONATAL INTENSIVE CARE UNITS. RESULTS OF THIS STUDY WILL DIRECTLY IMPACT INTERPRETATION OF THE DARBE TRIAL AND INFLUENCE WHETHER DARBEPOETIN SHOULD BE ADOPTED AS A NEUROPROTECTIVE THERAPY TO IMPROVE OUTCOMES FOR PRETERM INFANTS.

GH15-1621, GLOBAL HEALTH SECURITY PARTNERSHIP ENGAGEMENT

ENHANCE PUBLIC SAFETY AND SECURITY IN 31 TARGETED MUNICIPALITIES IN THE DEPARTMENTS OF QUETZALTENANGO, SOLALA, SAN MARCOS, AND RETALHULEU.

ENHANCE PUBLIC SAFETY AND SECURITY IN 31 TARGETED MUNICIPALITIES IN THE DEPARTMENTS OF QUETZALTENANGO, SOLALA, SAN MARCOS, AND RETALHULEU.

C60, MWCNTS AND THE INFLUENCE ON CARDIOVASCULAR, REPRODUCTIVE, AND DEVELOPMENTAL

CATALYTIC UPGRADING OF THERMOCHEMICAL INTERMEDIATES TO HYDROCARBONS.

CHRONIC KIDNEY DISEASES OF UNCERTAIN ETIOLOGY (CKDU) IN AGRICULTURAL COMMUNITIES (CURE) RESEARCH CONSORTIUM - SDCC - PROJECT SUMMARY/ABSTRACT A GROWING NUMBER OF GEOGRAPHICALLY DIVERSE REGIONS AROUND THE WORLD REPORT INCREASING RATES OF CHRONIC KIDNEY DISEASE OF UNCERTAIN OR UNKNOWN ETIOLOGY (CKDU), A LIFE-THREATENING CONDITION NOT ATTRIBUTABLE TO TRADITIONAL CHRONIC KIDNEY DISEASE RISK FACTORS. YET, THE ETIOLOGY OF CKDU REMAINS UNCLEAR AND DATA ARE LACKING ON CKDU PROGRESSION, BIOLOGICAL MANIFESTATIONS, GENETIC DETERMINANTS, AND RISK FACTORS THAT MAY EXPLAIN REGIONAL VARIATIONS. TO ADDRESS THESE CHALLENGES, THE NATIONAL INSTITUTES OF HEALTH HAS FORMED THE CHRONIC KIDNEY DISEASES OF UNCERTAIN ETIOLOGY (CKDU) IN AGRICULTURAL COMMUNITIES (CURE) RESEARCH CONSORTIUM. THE CONSORTIUM WILL DEVELOP A HARMONIZED STUDY PROTOCOL THAT CAN BE IMPLEMENTED IN MULTIPLE ENDEMIC REGIONS TO UNDERSTAND THE ETIOLOGIES OF CKDU AND DISEASE PROGRESSION AND TO IDENTIFY POTENTIAL THERAPEUTIC TARGETS AND PUBLIC HEALTH INTERVENTIONS. RTI INTERNATIONAL AND BOSTON UNIVERSITY ALONG WITH OUR PARTNERS FROM HARVARD UNIVERSITY, NATIONAL AUTONOMOUS UNIVERSITY OF NICARAGUA, UNIVERSITY OF COLORADO, AND STANFORD UNIVERSITY, PROPOSE TO ESTABLISH THE CURE RESEARCH CONSORTIUM SCIENTIFIC DATA COORDINATING CENTER (SDCC). THE SDCC WILL PROVIDE THE LEADERSHIP, INFRASTRUCTURE, AND TOOLS TO UNITE THE FIELD EPIDEMIOLOGY SITES, RENAL SCIENCE CORE, HUMAN HEALTH EXPOSURE ANALYSIS RESOURCE, AND NIH INTO A COHESIVE WHOLE BY PROMOTING CONSENSUS BUILDING AND COLLABORATIVE DECISION MAKING. THE SDCC'S ROLE IN CULTIVATING A COMMON RESEARCH AGENDA IS CRUCIAL TO THE CURE RESEARCH CONSORTIUM'S ABILITY TO IMPLEMENT ETHICAL EPIDEMIOLOGY RESEARCH DESIGNS; COMMON APPROACHES FOR DATA COLLECTION, AND BIOLOGICAL AND ENVIRONMENTAL ASSESSMENTS; BEST PRACTICES FOR DATA ANALYSIS AND DISSEMINATION; AND ANCILLARY RESEARCH STUDIES. SPECIFICALLY, THE SDCC WILL SUPPORT THE RESEARCH CONSORTIUM BY ACCOMPLISHING THE FOLLOWING AIMS: (1) ELUCIDATE THE LIKELY MULTIFACTORIAL ETIOLOGIES OF CKDU DEVELOPMENT AND PROGRESSION IN ENDEMIC REGIONS BY INTEGRATING A CLASSIC CASE-CONTROL STUDY WITH LONGITUDINAL ASSESSMENTS OF CASES TO ASSESS FACTORS FOR DISEASE PROGRESSION AND CONTROLS TO CAPTURE CKDU DEVELOPMENT; (2) PROMOTE CONSENSUS BUILDING AND FOSTER COLLABORATION AND COORDINATION BY PROVIDING SCIENTIFIC LEADERSHIP, EXPERTISE IN DATA SCIENCE AND ROBUST ANALYTICAL METHODS, AND COMMUNICATION, LOGISTICAL, AND OPERATIONAL SUPPORT; AND (3) ENHANCE CONSORTIUM RESEARCH EFFICIENCY, PRODUCTIVITY, AND SCIENTIFIC RIGOR BY PROVIDING SOUND STUDY MONITORING AND OVERSIGHT AND ESTABLISHING EFFICIENT DATA AND SPECIMEN MANAGEMENT SYSTEMS USING RELEVANT TECHNOLOGY AND DATA VISUALIZATION TOOLS. TOGETHER WITH A MULTIDISCIPLINARY TEAM OF CO-INVESTIGATORS, THE SDCC MULTIPLE PIS, JILL LEBOV, PHD (CONTACT PI), MARIE GANTZ, PHD, AND DANIEL BROOKS, PHD, BRING THE REQUIRED SCIENTIFIC AND ORGANIZATIONAL CAPABILITIES IN CONSORTIUM COORDINATION, PROJECT MANAGEMENT, EPIDEMIOLOGY, BIOSTATISTICS, DATA SCIENCE, NEPHROLOGY AND KIDNEY DISEASE RESEARCH, ENVIRONMENTAL AND OCCUPATIONAL HEALTH, GENETICS, AND ETHICAL CONDUCT OF INTERNATIONAL RESEARCH IN RESOURCE-LIMITED SETTINGS TO EFFECTIVELY MANAGE THE ACTIVITIES OF THE SDCC, THE CURE RESEARCH CONSORTIUM, AND THE CURE STUDY.

DATA COORDINATING CENTER FOR SICKLE CELL DISEASE IMPLEMENTATION CONSORTIUM (SCDIC)

RANDOM-ASSIGNMENT EVALUATION OF PAID MENTORING: PROCESS, OUTCOME AND COST-EFFECTIVENESS

TO PROVIDE ASSISTANCE TO THE IRAQI MINISTRY OF JUSTICE REAL ESTATE REGISTRY OFFICE IN ESTABLISHING A MODERNIZED NATIONAL PROPERTY TITLE RECORDING SYS

THE OBJECTIVE OF THE USAID/JAMAICA SUPPORTING VICTIMS OF VIOLENCE ACTIVITY IS TO STRENGTHEN AWARENESS OF AND ACCESS TO TRAUMA-INFORMED SERVICES FOR SURVIVORS, WITNESSES, AND PERPETRATORS OF VIOLENCE, LEADING TO SHIFTS IN ATTITUDES AND INCREASED RESILIENCE TO THE RISK FACTORS FACED BY YOUTH, FAMILIES, AND COMMUNITIES THAT MAKE THEM SUSCEPTIBLE TO CRIME AND VIOLENCE. SPECIFICALLY, THE ACTIVITY WILL STRENGTHEN THE CAPACITY OF THE GOVERNMENT OF JAMAICA (GOJ), NON-GOVERNMENTAL ORGANIZATIONS (NGOS), AND CIVIL SOCIETY ORGANIZATIONS (CSOS) TO PROVIDE QUALITY SUPPORT SERVICES AND FOSTER COORDINATION THROUGH COLLECTIVE ACTION INITIATIVES (CAIS) IN HOTSPOT COMMUNITIES THAT IDENTIFY, PREVENT, AND RESPOND TO VIOLENCE. BY FOCUSING ON VIOLENCE PREVENTION, SURVIVOR AND WITNESS PROTECTION, AND PERPETRATOR REHABILITATION, SVOV WILL SUPPORT USAID/JAMAICA’S DEVELOPMENT OBJECTIVE 2, WHICH INCLUDES YOUTH CRIME AND VIOLENCE PREVENTED IN TARGETED COMMUNITIES.

NEW ASSISTANCE PEPFAR GRANT ISSUED TO RTI, POP IS 45 MONTHS

INFORM ASIA: USAID'S HEALTH RESEARCH PROGRAM

THE FORENSIC TECHNOLOGY CENTER OF EXCELLENCE (FTCOE) SUPPORTS THE FORENSIC SCIENCE RESEARCH AND DEVELOPMENT PROGRAM OF THE NATIONAL INSTITUTE OF JUSTICE (NIJ) THROUGH EFFORTS TO TRANSITION TECHNOLOGIES FROM RESEARCH INTO PRACTICE. RTI INTERNATIONAL HAS PARTNERED WITH NIJ ON THE FTCOE SINCE 2011 TO PROVIDE OBJECTIVE SUPPORT TO FORENSIC SCIENCE STAKEHOLDERS. AS A WORLD-RENOWNED RESEARCH INSTITUTE, RTI HAS ASSEMBLED A WIDE RANGE OF ACADEMIC PARTNERS (INCLUDING FEPAC-ACCREDITED PARTNERS), FORENSIC LABORATORIES, AND PRACTITIONERS TO ACCOMPLISH NIJ’S OBJECTIVES AND TO SATISFY THE NEEDS OF THE FORENSIC AND CRIMINAL JUSTICE COMMUNITIES. THE FTCOE ADVANCES TECHNOLOGY THROUGH THE ASSESSMENT OF NIJ RESEARCH & DEVELOPMENT PROGRAMS FOR TESTING, EVALUATION, TECHNOLOGY TRANSITION AND IMPLEMENTATION, DISSEMINATION, AND COLLABORATIVE PARTNERSHIPS. IT SHARES KNOWLEDGE ABOUT EVIDENCE-BASED BEST PRACTICES USING A WIDE VARIETY OF STRATEGIES, INCLUDING FORUMS, REPORTS, WEBINARS, BLENDED LIVE AND ONLINE MEETINGS, PODCASTS, SOCIAL MEDIA, AND ITS WEBSITE. THE FTCOE ALSO ADDRESSES CHALLENGES TO THE FORENSIC SCIENCE COMMUNITY BY PROMOTING THE EXCHANGE OF IDEAS AND CONNECTING RESEARCHERS, PRACTITIONERS, INDUSTRY, AND OTHER STAKEHOLDERS IN OPEN DIALOGUES AT CONFERENCES. DURING THE PROPOSED PERIOD OF PERFORMANCE, AND SUBJECT TO NIJ DIRECTION UNDER THE COOPERATIVE AGREEMENT, THE RTI TEAM WILL PROVIDE TECHNOLOGY ASSISTANCE, FACILITATE THE DEMONSTRATION OF NEW TECHNOLOGIES, PROVIDE ACCESS TO RESEARCH AND EDUCATIONAL MATERIALS, AND DEVELOP AND COMMUNICATE THE SOCIAL IMPACT OF FORENSIC SCIENCE TO THE FIELD. ALONG WITH THE NIJ, THE RTI TEAM WILL WORK TO DEVELOP CRITERIA TO EVALUATE THESE AND OTHER PROGRAMS. PROPOSED INITIATIVES SUCH AS TECHNOLOGY IMPLEMENTATION WORKSHOPS AND ASSISTANCE PROGRAMS, IN-FIELD EVALUATIONS, GUIDES FOR BEST PRACTICES, AND INTERLABORATORY COMPARISON STUDIES WILL HELP GUIDE RESEARCH DISSEMINATION AND TECHNOLOGY ASSISTANCE. BY DIRECTLY ENGAGING THE COMMUNITY THROUGH DISCUSSIONS AMONG LABORATORY DIRECTORS AND RESEARCHERS (FLNTWG, VIRTUAL ROUND TABLES), PARTICIPATING IN NATIONAL CONFERENCES WITH PRACTITIONERS (AAFS, ASCLD, IAI, IACME), WORKING WITH LEGAL PROFESSIONALS (EXPERT WITNESS WORKSHOPS), AND ASSISTING THE MEDICOLEGAL COMMUNITY (WORKLOAD ANALYSIS), THE FTCOE WILL PROVIDE A STABLE PLATFORM FOR NIJ INITIATIVES. PROPOSED OUTREACH ACTIVITIES (GUIDANCE DOCUMENTS, FORUMS) SPECIFICALLY DESIGNATED FOR DIVERSE POPULATIONS WOULD PROMOTE INCLUSION WITHIN THE FORENSIC COMMUNITY. DEVELOPMENT OF A NATIONAL FORENSIC SCIENCE LIBRARY AND ADDITIONAL LIBRARY BASED REPOSITORIES (SCHOLARLY PRODUCTS, VALIDATED METHODS, FORENSIC COURT DECISIONS, LABORATORY STANDARD OPERATING PROCEDURES) BY THE FTCOE WOULD PROVIDE RESEARCHERS, LABORATORY DIRECTORS, AND PRACTITIONERS INVALUABLE, EASILY SEARCHABLE RESOURCES. NIJ AND ITS FTCOE TEAM WILL WORK TOWARD A NEW STRATEGIC FUTURE OF PROVIDING EVIDENCE-BASED RESOURCES ABOUT FORENSIC TECHNOLOGIES AND EMERGING CHALLENGES TO ENABLE FORWARD-LEANING METHODS TO AGILELY DRIVE INNOVATION.

THE LEARNING, ADVANCING, UNDERSTANDING, NURTURING AND COLLABORATING HUB - THE LEARNING, ADVANCING, UNDERSTANDING, NURTURING AND COLLABORATING HUB—LAUNCH—DEVELOPED BY RTI INTERNATIONAL IN PARTNERSHIP WITH POWER TO DECIDE, HEALTHY TEEN NETWORK, SISTERLOVE, AND YOUTH COLLABORATORY, WILL ADVANCE EQUITY IN ADOLESCENT SEXUAL HEALTH BY IDENTIFYING, RECRUITING, AND PARTNERING WITH TEAMS OF INNOVATORS THAT HAVE IDENTIFIED INITIAL OR EMERGENT SOLUTIONS TO THE CURRENT GAPS IN EVIDENCE FOR PROMOTING ADOLESCENT SEXUAL HEALTH. OVER 5 YEARS, LAUNCH WILL RECRUIT AND SUPPORT AT LEAST 25 INNOVATION DEVELOPMENT TEAMS. THESE TEAMS WILL HAVE EXISTING PROTOTYPES THAT DEMONSTRATE PROMISE IN ADVANCING EQUITY IN ADOLESCENT SEXUAL HEALTH OUTCOMES. WE WILL RECRUIT AND ENGAGE DIVERSE COHORTS OF INNOVATION DEVELOPMENT TEAMS THAT INCLUDE BOTH EXISTING GRANTEES FUNDED BY THE OFFICE OF POPULATION AFFAIRS (OPA) AND TEAMS FROM COMMUNITIES THAT HAVE NOT HISTORICALLY RECEIVED INVESTMENTS IN ADOLESCENT SEXUAL HEALTH. BY INCLUDING AN INTENTIONAL FOCUS ON EQUITY THROUGHOUT THE ACCELERATOR PROCESS—RECRUITMENT, SELECTION, SUPPORT, AND LEARNING—LAUNCH WILL CONTRIBUTE TO THE PIPELINE OF EVIDENCE-BASED INTERVENTIONS THAT ARE AVAILABLE FOR FAMILIES, COMMUNITIES, AND SCHOOLS TO USE TO SUPPORT YOUNG PEOPLE AND THE ADULTS IN THEIR LIVES. OTHER KEY PROJECT ACTIVITIES WILL INCLUDE DISSEMINATING THE LEARNINGS FROM THE LAUNCH ACCELERATOR AND OUR INNOVATION DEVELOPMENT TEAMS, MONITORING AND IMPROVING THE LAUNCH ACCELERATOR, AND COLLABORATING WITH OTHER INNOVATION HUBS AND OPA GRANTEES MORE BROADLY.

COMPREHENSIVE HIV/AIDS PREVENTION, CARE, TREATMENT AND SUPPORT PROJECT WITH THE UGANDA PEOPLE DEFENSE FORCES

TRANSFUSION OF PREMATURITY EARLY SCHOOL AGE FOLLOW-UP (TOP 5) DCC

DOD HIV/AIDS PREVENTION, CARE, AND TREATMENT PROGRAM - SOUTH SUDAN: IMPROVING HIV/AIDS CARE AND TREATMENT

COMPREHENSIVE HIV/AIDS PREVENTION CARE, TREATMENT AND SUPPORT PROJECT WITH THE UGANDA PEOPLE'S DEFENSE FORCES

MULTI-COUNTRY SUPPORT FOR HIV SURVEILLANCE AND RESEARCH STUDIES

DEATHS IN CUSTODY REPORTING PROGRAM AND ANNUAL SURVEY OF JAILS, 2016-2020

STILLBIRTH NETWORK

DARBEPOETIN TRIAL TO IMPROVE RED CELL MASS AND NEUROPROTECTION IN PRETERMS - DCC

THE BUREAU OF JUSTICE ASSISTANCE (BJA) SUPPORTS STATE AND LOCAL JURISDICTIONS WITH MEETING THE CHALLENGES ASSOCIATED WITH THE PROVISION OF FORENSIC SERVICES THROUGH SEVERAL FORENSIC SCIENCE GRANT PROGRAMS. AGENCIES RELY ON THESE PROGRAMS TO MEET CRIMINAL JUSTICE OBJECTIVES SUCH AS IMPROVING CASE OUTCOMES, STRENGTHENING PUBLIC SAFETY, AND REBUILDING TRUST WITH THE COMMUNITIES THEY SERVE. TO IMPROVE THE EFFICIENCY AND STRATEGIC USE OF THESE PROGRAMS, BJA CREATED THE FORENSICS TRAINING AND TECHNICAL ASSISTANCE (TTA) PROGRAM. RTI INTERNATIONAL IS A TRUSTED TTA PARTNER TO BJA AND WILL BUILD ON THE KNOWLEDGE GAINED FROM LEADING THE NATIONAL SEXUAL ASSAULT KIT INITIATIVE TTA PROGRAM TO ASSIST THE FORENSIC PROGRAM GRANTEES WITH IMPLEMENTING SUSTAINABLE POLICIES ALIGNED WITH NATIONAL RECOMMENDATIONS AND BEST PRACTICES. RTI’S DEMONSTRATED TTA MODEL COMBINES EVIDENCE-BASED SOLUTIONS AND PRACTITIONER-BASED STRATEGIES RESULTING IN TTA RESOURCES THAT ARE PRACTITIONER CENTRIC AND EASILY IMPLEMENTED. THESE RESOURCES WILL SUPPORT GRANTEES WITH CREATING SUSTAINABLE APPROACHES FOR THE PROVISION OF FORENSIC SERVICES. AS A RESPECTED PARTNER TO THE CRIMINAL JUSTICE, MEDICAL EXAMINER AND CORONER, AND CRIME LABORATORY COMMUNITIES, RTI UNDERSTANDS THAT GRANTEES MUST ADDRESS MULTIPLE CAPACITY ENHANCEMENT DEMANDS AND THEREFORE, CREATING COHESIVE STRATEGIES TO SUPPORT FORENSIC TESTING OF CASEWORK, LABORATORY CAPACITY ENHANCEMENT, AND IMPLEMENTATION OF EMERGING TECHNOLOGIES IS OFTEN MET WITH CHALLENGES AT THE DISCIPLINE, AGENCY, AND INTER-AGENCY LEVEL. TO ADDRESS THESE CHALLENGES, RTI’S TTA MODEL INCLUDES THE FOLLOWING PRINCIPLES: CREATING A SUSTAINABLE MULTIDISCIPLINARY TEAM, UNDERSTANDING CASE CONNECTIVITY, PROVIDING TRAINING FOR ADVANCED DNA TESTING INCLUDING FORENSIC GENETIC GENEALOGY AND DEVELOPING SUSTAINABLE POLICIES AND BEST PRACTICES. TO ENSURE RELEVANT AND TIMELY TTA RESOURCES, THE MODEL LEVERAGES COLLABORATION BETWEEN AN ADVISORY BOARD, COMPOSED OF NATIONALLY RECOGNIZED FORENSIC ORGANIZATIONS; TTACOACHES COMPOSED OF RTI STAFF WHO ARE FORMER SCIENTISTS AND PRACTITIONERS; AND A CADRE OF RESPECTED, STATURED, SUBJECT MATTER EXPERTS. THIS CONSORTIUM OF EXPERTS WILL ASSIST GRANTEES WITH APPROACHES THAT EFFECTIVELY USE FUNDING, REDUCE REDUNDANCIES, AND OPTIMIZE FORENSIC SERVICES. TO INFORM STRATEGIC PLANNING FOR PROGRAM SUCCESS, THE RTI TTA TEAM WILL COLLECT AND EVALUATE PERFORMANCE METRIC DATA. COMPREHENSIVE PERFORMANCE METRIC COLLECTION INFORMS STAKEHOLDERS, DEMONSTRATES IMPACT, AND PROVIDES JUSTIFICATION FOR CONTINUED PROGRAM SUPPORT AS WELL AS TRANSPARENCY TO BJA PROGRAM DOLLARS INVESTED. IN SUMMARY, RTI WILL ASSIST BJA WITH ACCURATELY ASSESSING BOTH THE NEW FORENSICS TTA PROGRAM AND THE EXISTING FORENSIC PROGRAMS, THEREBY STRENGTHENING AND IMPROVING THE QUALITY AND PRACTICE OF FORENSIC SCIENCE.

THE BUREAU OF JUSTICE STATISTICS (BJS) COLLECTS OBJECTIVE, TIMELY, HIGH-QUALITY DATA FROM U.S. LAW ENFORCEMENT AGENCIES (LEAS). DATA COLLECTION EFFORTS ARE HAMPERED BY THE COMPLICATED, DECENTRALIZED STRUCTURE OF AMERICAN POLICING, OPERATED BY LOCAL, COUNTY, STATE, TRIBAL, AND SPECIAL JURISDICTIONS. SUCCESSFUL EXECUTION OF BJSS LAW ENFORCEMENT DATA COLLECTION PORTFOLIO REQUIRES SUBJECT-MATTER EXPERTISE IN POLICING, EXPERIENCE WITH TESTING AND REFINING SURVEY INSTRUMENTS TO ENSURE INTEGRITY OF KEY CONCEPTS, FLEXIBLE DATA COLLECTION TOOLS, ABILITY TO CARRY OUT MULTIMODAL AGENCY OUTREACH, AND CAPABILITY TO IDENTIFY EMERGING TOPICS AND DEVELOP RELATED INSTRUMENTATION. THE PURPOSE OF THE LAW ENFORCEMENT CORE STATISTICS (LECS) PROGRAM IS TO ENUMERATE AND DESCRIBE THE VARIATIONS AND CHARACTERISTICS OF U.S. LEAS THROUGH THE 2024 LAW ENFORCEMENT MANAGEMENT AND ADMINISTRATIVE STATISTICS (LEMAS) CORE, 2026 CENSUS OF STATE AND LOCAL LAW ENFORCEMENT AGENCIES (CSLLEA), AND A 2027 LEMAS SUPPLEMENT. COLLECTIONS WILL BE FACILITATED BY WORK TO IMPROVE THE RELIABILITY AND TIMELINESS OF THE LAW ENFORCEMENT AGENCY ROSTER (LEAR), MANAGED BY THE AGENCY RECORDS MANAGEMENT SYSTEM (ARMS). A TOPICAL SUPPLEMENT TO THE LEMAS WILL ALSO BE DEVELOPED. KEY OBJECTIVES OF THE 2023 LECS PROGRAM WILL INCLUDE MAINTAINING CONSISTENCY WITH CRITICAL ITEMS OF PAST LEMAS AND CSLLEA COLLECTIONS, DEVELOPING A AND CONDUCTING A LEMAS SUPPLEMENT, ENSURING HIGH RESPONSE RATES AND REPRESENTATIVENESS, INVESTIGATING THE FEASIBILITY OF CONDUCTING MORE FREQUENT LEMAS SURVEYS, AND DEVELOPING STREAMLINED METHODS OF UNIVERSE MAINTENANCE. RTI INTERNATIONAL STAFF OFFER BJS THEIR EXPERTISE IN LAW ENFORCEMENT RESEARCH, AND THEY UNDERSTAND THE DATA NEEDS OF STAKEHOLDERS. THETEAM OF SUBJECT MATTER EXPERTS, STATISTICIANS, PROGRAMMERS, SURVEY METHODOLOGISTS, AND DATA COLLECTION MANAGERS HAVE DEMONSTRATED AN ABILITY TO SUCCESSFULLY ADDRESS THE CHALLENGES OF MAINTAINING FRAME INTEGRITY, COLLECTING HIGH-QUALITY DATA FROM LEAS, AND DELIVERING WELL-DOCUMENTED AND ACCURATE DATASETS. DURING THE 2015 AND 2019 LECS PROJECTS, THE RTI TEAM HAS CONDUCTED THE 2016 LEMAS, 2018 CSLLEA, 2020 LEMAS, AND 2022 CSLLEA; CREATED AND MAINTAINED THE LEAR; AND PERFORMED THE RESEARCH AND DEVELOPMENT ACTIVITIES CALLED FOR. RTI HAS PARTNERED WITH THE INTERNATIONAL ASSOCIATION OF CHIEFS OF POLICE (IACP) TO CARRY OUT THE 2023 LECS. FURTHERMORE, THE RTI/IACP TEAM HAS DEMONSTRATED ITS ABILITY TO WORK CLOSELY WITH OTHER POLICING STAKEHOLDERS TO PRODUCE LETTERS OF SUPPORT FOR THE LEMAS AND CSLLEA. OUTCOMES FROM THE 2023 LECS WILL INCLUDE DATASETS AND SUPPORTING DOCUMENTATION FOR THE 2024 LEMAS, 2026 CSLLEA, AND LEMAS SUPPLEMENT; AN UPDATED LEAR FILE AND SOURCE CODE ASSOCIATED WITH ARMS; AND A FEASIBILITY REPORT ON CONDUCTING MORE FREQUENT ITERATIONS OF LEMAS.

SCHOOL SAFETY AND SCHOOL-BASED MENTAL HEALTH SERVICES IN A LARGE METROPOLITAN SCHOOL DISTRICT

APP FOR AAD 936-3090

HEAL INITIATIVE: RESEARCH TO FOSTER AN OPIOID USE DISORDER TREATMENT SYSTEM PATIENTS CAN COUNT ON - 0BPROJECT SUMMARY/ABSTRACT OPIOID OVERDOSE DEATHS REACHED THE HIGHEST LEVEL EVER IN 2021. MEDICATIONS TO TREAT OPIOID USE DISORDER (MOUD) CAN MARKEDLY REDUCE OVERDOSE RISKS WHEN TAKEN FOR LONG ENOUGH. MORE THAN 650,000 PEOPLE RECEIVE MOUD IN OPIOID TREATMENT PROGRAMS (OTPS) ANNUALLY. UNFORTUNATELY, ON AVERAGE, LESS THAN HALF OF PATIENTS STAY IN OPIOID USE DISORDER (OUD) TREATMENT FOR THE RECOMMENDED MINIMUM 1 YEAR OF TIME. OTP RETENTION AND OUTCOME QUALITY MEASURES (I.E., “AUDIT AND FEEDBACK”) MAY IMPROVE TREATMENT RETENTION RATES AND OUTCOMES. QUALITY MEASURES CAN ALSO HELP MONITOR THE EFFECT OF NEW OTP REIMBURSEMENT AND REGULATORY POLICIES. EVENTUALLY, OTP QUALITY MEASURES COULD BE INCORPORATED INTO THE FEDERAL GOVERNMENT’S PUBLIC FACING HEALTHCARE PROVIDER COMPARE WEBSITE. HOWEVER, RESEARCH IS NEEDED TO DETERMINE HOW TO MOST EFFECTIVELY CREATE AND DISSEMINATE OTP QUALITY MEASURES. THE LITERATURE ON AUDIT AND FEEDBACK POINTS TO THREE FEATURES THAT INFLUENCE THE PROBABILITY THAT MEASURES WILL RESULT IN IMPROVED QUALITY: (1) THE CHARACTERISTICS OF THE MEASURES AND BENCHMARKS, (2) THE KNOWLEDGE THAT PROVIDERS HAVE ABOUT HOW TO IMPROVE THE MEASURES, AND (3) THE CONTROL THAT PROVIDERS HAVE OVER THE FACTORS THAT MATTER TO IMPROVE THE MEASURE. THIS STUDY WILL TEST APPROACHES FOR OPTIMIZING EACH OF THESE FACTORS. NIDA RFA-DA-23-046 IS SUPPORTING MULTI-PROJECT OUD QUALITY MEASUREMENT AND MANAGEMENT RESEARCH CENTERS THAT PAIR RESEARCHERS WITH PARTNER ORGANIZATIONS THAT HAVE AN OUD QUALITY MEASUREMENT AND MANAGEMENT STRATEGY THAT RESEARCH COULD ADVANCE. RTI INTERNATIONAL, UNIVERSITY OF CALIFORNIA LOS ANGELES, AND BEACON HEALTH CONNECTICUT ARE THE RESEARCH ORGANIZATIONS LEADING THIS STUDY. THEY ARE PARTNERING WITH TWO ORGANIZATIONS THAT NEED TO DEVELOP AN EFFECTIVE OTP QUALITY MEASUREMENT AND MANAGEMENT SYSTEM: BAYMARK HEALTH SERVICES AND THE LOS ANGELES COUNTY DIVISION OF SUBSTANCE ABUSE PREVENTION AND CONTROL. THE TEAM IS IMPLEMENTING THREE INTER-RELATED RESEARCH PROJECTS WITH THE FOLLOWING OVERALL AIMS: OVERALL AIM 1. CREATE AND PSYCHOMETRICALLY TEST OTP MEASURES OF RETENTION, OVERDOSE EMERGENCY DEPARTMENT VISITS, OVERDOSE HOSPITALIZATIONS, AND MORTALITY WITH BENCHMARKS AND TOOLKITS DESCRIBING HOW OTPS CAN IMPROVE RETENTION. OVERALL AIM 2. TEST THE EFFECT OF THE GIVING OTPS QUALITY MEASURES AND INFORMATION ON HOW TO IMPROVE RETENTION (A RETENTION TOOLKIT), WITH AND WITHOUT QUALITY IMPROVEMENT TRAINING, BY CONDUCTING A CLUSTERED RANDOMIZED TRIAL THAT ASSIGNS OTPS TO RECEIVE EITHER: (1) RETENTION AND OUTCOME MEASURES WITH THE TOOLKIT; OR (2) RETENTION AND OUTCOME MEAURES WITH THE TOOLKIT AS WELL AS QUALITY IMPROVEMENT (QI) TRAINING (I.E., NIATX) (ARM 2), OR (3) TREATMENT AS USUAL (CONTROL ARM). OVERALL AIM 3. TEST THE EFFECT OF ALIGNING OTP-LEVEL AND LA COUNTY POPULATION-LEVEL OUD MEASURES ON RETENTION AND OUTCOMES IN LA COUNTY RELATIVE TO OTHER COUNTIES IN CALIFORNIA.

RESEARCH AND SERVICE PROJECT

INVESTIGATION OF THC RECEPTORS

SHELBY COUNTY SCHOOL DISTRICT COMPREHENSIVE SCHOOL SAFETY INITIATIVE

PROSPECTIVE COHORT STUDY OF STELLATE GANGLION BLOCK FOR TREATMENT OF POSTTRAUMATIC STRESS DISORDER SYMPTOMS AND OTHER NON-PAIN CONDITIONS

ADVANCED, ENERGY-EFFICIENT HYBRID MEMBRANE SYSTEM FOR INDUSTRIAL WATER REUSE

PATHWAYS TO PARTICIPATION (PFP)

CO2-BINDING ORGANIC LIQUIDS

POSITIVE HEALTH CHECK EVALUATION TRIAL

INVESTIGATION OF SYNTHETIC CANNABINOID EXPOSURES AND PHARMACOLOGICAL CONSEQUENCES

INTENSIFIED WATER-LEAN SOLVENT CO2 CAPTURE SYSTEM FOR CEMENT FLUE GAS

AN EFFECTIVENESS REPLICATION OF TARGETED READING INSTRUCTION: INVESTIGATING LONG-TERM STUDENT AND TEACHER IMPACTS

2017 NCS-X NIBRS ESTIMATION PROJECT

SUBCUTANEOUS CONTRACEPTIVE AND HIV IMPLANT ENGINEERED FOR LONG-ACTING DELIVERY

RBS SURVEY

INTERNATIONAL EPI DATABASES TO EVALUATE AIDS (IEDEA) IN CENTRAL AFRICA (REGION 9)

COMMUNITY VIOLENCE AND REPRODUCTIVE HEALTH AMONG YOUTH IN SALINAS, CALIFORNIA

2/2 NEONATAL PLATELET TRANSFUSION THRESHOLD TRIAL (NEOPLATT) - ABSTRACT EXTREMELY PRETERM INFANTS BORN AT 23 TO 26 WEEKS GESTATION HAVE THE HIGHEST INCIDENCE OF THROMBOCYTOPENIA AND BLEEDING AND THE HIGHEST MORTALITY AMONG NEONATES ADMITTED TO THE NEONATAL INTENSIVE CARE UNIT (NICU). APPROXIMATELY 20% OF EXTREMELY PRETERM INFANTS DEVELOP A SEVERE INTRACRANIAL HEMORRHAGE, ALMOST ALWAYS IN THE FIRST WEEK OF LIFE, WHICH IS THE HIGHEST RISK PERIOD FOR BLEEDING. PLATELET TRANSFUSIONS ARE FREQUENTLY ADMINISTERED TO EXTREMELY PRETERM NEONATES AT HIGHER PLATELET COUNT THRESHOLDS THAN THOSE USED IN OLDER CHILDREN AND ADULTS TO DECREASE THE RISK OF BLEEDING. PARADOXICALLY, A RECENT MULTICENTER RANDOMIZED TRIAL OF INFANTS <34 WEEKS GESTATION CONDUCTED IN EUROPE (PLANET-2) FOUND THAT NEONATES RANDOMIZED TO A LOWER PLATELET TRANSFUSION THRESHOLD OF 25X10^9/L, COMPARED TO 50X10^9/L, HAD A SIGNIFICANTLY LOWER RISK OF DEATH OR SERIOUS BLEEDING. HOWEVER, 39% OF INFANTS RECEIVED ONE OR MORE PLATELET TRANSFUSIONS BEFORE ENROLLMENT, AND THE MEDIAN AGE AT RECRUITMENT WAS 7-8 DAYS, SUGGESTING THAT A HIGH PROPORTION OF THROMBOCYTOPENIC INFANTS IN THE FIRST WEEK OF LIFE WERE NOT RANDOMIZED BEFORE BEING TRANSFUSED. THIS LIKELY CONTRIBUTED TO THE PERSISTENT UNCERTAINTY REGARDING OPTIMAL PLATELET TRANSFUSION THRESHOLDS, SPECIFICALLY IN THE MOST IMMATURE PRETERM INFANTS IN THE FIRST WEEK OF LIFE. IN A RECENT SURVEY, 57% OF RESPONDING EUROPEAN NICUS CONTINUED TO USE THRESHOLDS ABOVE 25X10^9/L IN INFANTS <28 WEEKS’ GESTATION AND <7 DAYS OLD. ANOTHER QUESTION RAISED BY PLANET-2 WAS WHETHER THRESHOLDS LOWER THAN 25X10^9/L CAN BE SAFELY APPLIED TO EXTREMELY PRETERM INFANTS AFTER THE FIRST WEEK OF LIFE, WHEN THE RISK OF BLEEDING IS MUCH LOWER. THE NEONATAL PLATELET TRANSFUSION THRESHOLD (NEOPLATT) TRIAL WAS SPECIFICALLY DESIGNED TO ADDRESS THESE CRITICAL QUESTIONS AND WILL TEST THE HYPOTHESIS THAT, AMONG EXTREMELY PRETERM INFANTS BORN AT 23 TO 26 WEEKS GESTATION, A LOW PLATELET TRANSFUSION THRESHOLD, COMPARED TO A HIGH THRESHOLD, WILL IMPROVE SURVIVAL WITHOUT MAJOR OR SEVERE BLEEDING UP TO 40 WEEKS POSTMENSTRUAL AGE. THE SPECIFIC AIMS WILL (1) DETERMINE THE COMPARATIVE EFFECTIVENESS OF LOW PLATELET TRANSFUSION THRESHOLDS (25X10^9/L IN THE 1ST WEEK OF LIFE, 20X10^9/L THEREAFTER), COMPARED TO HIGH THRESHOLDS (50X10^9/L IN THE 1ST WEEK, 35X10^9/L THEREAFTER), ON THE RISKS OF DEATH OR MAJOR/SEVERE BLEEDING FOR INFANTS BORN AT 23 TO 26 WEEKS GESTATION; (2) DETERMINE THE COMPARATIVE EFFECTIVENESS OF HIGH VS. LOW THRESHOLDS ON MORTALITY AS A KEY SECONDARY OUTCOME, ALONG WITH SERIOUS MORBIDITIES AND NEED FOR PLATELET TRANSFUSION. IMPORTANTLY, THE TRIAL WILL BE CONDUCTED IN THE NICHD NEONATAL RESEARCH NETWORK, WHICH IS A CONSORTIUM OF NICUS WITH ESTABLISHED SITE RESEARCH INFRASTRUCTURE AND EXTENSIVE EXPERIENCE CONDUCTING MULTICENTER CLINICAL TRIALS WITH EARLY RECRUITMENT OF HIGH-RISK NEONATES. IF OUR HYPOTHESIS IS CONFIRMED, THIS TRIAL WILL CHANGE THE CURRENT PARADIGM REGARDING THE LIBERAL USE OF PLATELET TRANSFUSIONS TO PREVENT BLEEDING TOWARDS THE AVOIDANCE OF UNNECESSARY PLATELET TRANSFUSIONS IN THIS POPULATION. MOST IMPORTANTLY, KNOWLEDGE GENERATED FROM THE NEOPLATT TRIAL MAY IMPROVE OUTCOMES IN OUR MOST VULNERABLE PATIENTS, WHILE ALSO DECREASING COSTS AND CONSERVING RESOURCES.

LA HIV TREATMENT IN PEDIATRICS - PROJECT SUMMARY THE LONG-TERM GOAL OF THIS PROPOSED PROJECT IS TO DEVELOP AN INNOVATIVE, END-USER INFORMED DELIVERY OF ANTIRETROVIRALS VIA IMPLANTABLE SYSTEM FOR YOUNG CHILDREN (DAISY). DAISY WILL OFFER A COMBINATION OF PRODUCT ATTRIBUTES THAT SURPASS EXISTING ORAL REGIMENS FOR ANTIRETROVIRAL TREATMENT (ART) IN YOUNG CHILDREN (AGES 2-5): LONG-TERM ART (AT LEAST 6 MONTHS), REVERSIBILITY DURING DRUG DELIVERY, USER INDEPENDENCE, BIODEGRADATION, AND DISCRETION OF USE. WITH A FOCUS ON PREFERRED USER CHARACTERISTICS IN THE REPUBLIC OF SOUTH AFRICA (RSA), THE DAISY PLATFORM AIMS TO EXTEND TIME BETWEEN CLINIC VISITS AND SIMPLIFY DOSING REGIMENS OF ANTIRETROVIRALS (ARVS) IN YOUNG CHILDREN TO ULTIMATELY IMPROVE ADHERENCE, AND THUS, VIRAL SUPPRESSION, DISEASE PROGRESSION, AND CHILDHOOD DEVELOPMENT. THE IMPLANT IS UNIQUELY RETRIEVABLE, IF NEEDED, FOR THE DURATION OF ARV DELIVERY, BUT OTHERWISE REMAINS STATIONARY AND BIODEGRADES AFTER DEPLETION OF THE DRUG. IN THIS MANNER, REVERSAL OF DRUG DELIVERY IS POSSIBLE IN THE CASE OF ADVERSE REACTIONS OR NEED TO CHANGE IN THE REGIMEN. THE IMPLANT TECHNOLOGY ALSO DECOUPLES DRUG DELIVERY CHARACTERISTICS FROM BIODEGRADATION PROPERTIES AND CAN ACHIEVE ZERO-ORDER KINETICS OF ARV RELEASE. THE PROPOSED SPECIFIC AIMS DIRECTLY ADDRESS THE GOALS OF THIS NATIONAL INSTITUTES OF HEALTH OPPORTUNITY (RFA-AI-18-057) FOR INNOVATIVE LONG-ACTING DRUG DELIVERY SYSTEMS FOR TREATMENT OF HIV-1 INFECTED CHILDREN. THE SPECIFIC AIMS ARE TO (1) DEVELOP THE DAISY PRODUCT, INCLUDING ARV FORMULATIONS, IMPLANT FORM FACTORS, AND CHARACTERIZATION OF BIODEGRADATION; (2) EVALUATE SAFETY, PHARMACOKINETICS, AND EFFICACY OF DOWN-SELECTED DAISY PROTOTYPES DURING PRECLINICAL STUDIES IN NEW ZEALAND WHITE RABBITS AND NONHUMAN PRIMATES; AND (3) INFORM TECHNOLOGY DEVELOPMENT VIA ITERATIVE SOCIO-BEHAVIOR RESEARCH WITH END-USER POPULATIONS IN RSA. IMPORTANTLY, THE PROPOSED WORK WILL LEVERAGE ACHIEVEMENTS MADE DURING EARLIER PROGRAMS IN DEVELOPING THE IMPLANT PLATFORM AND WILL BUILD ON THIS WORK IN THE FOLLOWING KEY ASPECTS: LONG-TERM DELIVERY (UP TO 6 MONTHS) OF MULTIPLE ARVS AND INCORPORATION OF END-USER ACCEPTABILITY DATA FROM RSA INTO A TARGET PRODUCT PROFILE. OUR RESEARCH STRATEGY IS MILESTONE-DRIVEN, WITH CLEAR EXPECTED DELIVERABLES GUIDING PROGRESS OF PRODUCT DEVELOPMENT TO ALIGN WITH FUTURE CLINICAL TRANSLATION.

RTI HEAL HARM REDUCTION NETWORK COORDINATION CENTER - PROJECT SUMMARY/ABSTRACT THE MAGNITUDE OF THE OVERDOSE CRISIS HAS BROUGHT AN INCREASED FOCUS TO A WELL-KNOWN PUBLIC HEALTH TOOL REFERRED TO AS HARM REDUCTION—A SET OF STRATEGIES OR PROGRAMS IMPLEMENTED TO REDUCE THE NEGATIVE CONSEQUENCES ASSOCIATED WITH THE USE OF OPIOIDS AND OTHER SUBSTANCES WHILE MAINTAINING RESPECT FOR THE INDIVIDUAL. RECOGNIZING THE IMPORTANCE OF HARM REDUCTION IN ADDRESSING THE ONGOING OPIOID CRISIS AND SUBSTANCE USE DISORDER MORE BROADLY, THE NATIONAL INSTITUTES OF HEALTH (NIH), THROUGH THE HELPING TO END ADDICTION LONG-TERM (HEAL) INITIATIVE, INTENDS TO LAUNCH A HARM REDUCTION NETWORK (HRN) OF NINE RESEARCH PROJECTS AND A COORDINATION CENTER (CC) TO IMPROVE UNDERSTANDING OF THE EFFECTIVENESS AND OUTCOMES OF IMPLEMENTATION OF HARM REDUCTION STRATEGIES. RTI PROPOSES TO SERVE AS THE CC FOR THE HRN. IN THIS CAPACITY, RTI WILL PROVIDE SCIENTIFIC, ADMINISTRATIVE, AND LOGISTICAL SUPPORT FOR THE HRN TO FACILITATE NETWORK COORDINATION AND COMMUNICATION (AIM 1). RECOGNIZING THE IMPORTANCE OF DATA HARMONIZATION FOR HARM REDUCTION RESEARCH, RTI WILL FACILITATE A STAKEHOLDER-ENGAGED PROCESS OF DEVELOPING COMMON METRICS AND MEASURES TO SUPPORT HEAL DATA HARMONIZATION, DATA INFRASTRUCTURE AND SHARING, AND PROVIDE METHODOLOGY CONSULTATIONS (AIM 2). GIVEN THE IMPORTANCE OF INVOLVING STAKEHOLDER VOICES TO ADEQUATELY IDENTIFY THE PROBLEMS FACED BY SPECIFIC POPULATIONS AND SERVE THEM WITH EVIDENCE-BASED SOLUTIONS, RTI WILL FACILITATE A CONCEPTUALLY DRIVEN ENGAGEMENT OF STAKEHOLDERS REPRESENTING INDIVIDUALS AND COMMUNITIES AT HIGHEST RISK FOR HARMS ASSOCIATED WITH DRUG USE (AIM 3). TO ACCELERATE THE TRANSLATION OF RESEARCH FINDINGS INTO PRACTICE, RTI WILL ESTABLISH A RESEARCH INFRASTRUCTURE THAT FACILITATES THE TIMELY DEVELOPMENT AND DISSEMINATION OF TRANSLATIONAL PRODUCTS, INCLUDING EFFECTIVE DISSEMINATION STRATEGIES THROUGH USER-CENTERED DESIGN (AIM 4). OUR CC TEAM IS LED BY MULTIPLE PRINCIPAL INVESTIGATORS DRS. EMMANUEL OGA AND JESSICA CANCE, WHO ARE EXPERIENCED LEADERS OF THE LARGEST EXISTING NIH HEAL MULTISITE EFFORTS. THE BROADER TEAM OF CORE LEADERS, CO-INVESTIGATORS, AND SCIENTIFIC ADVISORS BRING SIGNIFICANT EXPERTISE IN HARM REDUCTION, DATA HARMONIZATION, STATISTICAL METHODOLOGY, DATA INFRASTRUCTURE DEVELOPMENT AND MANAGEMENT, AND IMPLEMENTATION SCIENCE. RTI HAS EXTENSIVE EXPERIENCE SUCCESSFULLY RUNNING CCS AND RETAINS SUBSTANTIVE COLLECTIVE EXPERTISE IN SUBSTANCE USE RESEARCH, HARM REDUCTION, AND COMMUNITY ENGAGEMENT TO IMPLEMENT A PORTFOLIO OF SCIENTIFIC AND SUPPORT ACTIVITIES FOR THE NETWORK. THE RTI CC WILL PROVIDE THE NEEDED ROBUST CENTRAL OPERATION TO COORDINATE A COMPREHENSIVE MULTIPROJECT, MULTIPRONGED RESEARCH ENDEAVOR THAT DEMONSTRATES AN UNDERSTANDING OF THE METHODOLOGICAL COMPLEXITIES OF INTEGRATING EVIDENCE FROM MULTIPLE SOURCES WITH DIVERSE POPULATIONS AND OUTCOMES.

ALCOHOL USE DISORDER TREATMENT SIMULATION: MODELING TREATMENT IMPACTS ON ALCOHOL-RELATED DISPARITIES - PROJECT SUMMARY/ABSTRACT EXCESSIVE DRINKING RESULTS IN TREMENDOUS ECONOMIC AND SOCIAL COSTS AND IS A LEADING CAUSE OF PREVENTABLE DEATH IN THE US. ONLY A SMALL MINORITY OF PEOPLE WITH ALCOHOL USE DISORDER (AUD) RECEIVE APPROPRIATE SERVICES, AND THERE ARE LARGE DISPARITIES IN ACCESS TO ALCOHOL HEALTH SERVICES FOR PEOPLE BASED ON RACE/ETHNICITY, GENDER, SOCIOECONOMIC STATUS, AND URBANICITY. THE PROPOSED STUDY WILL ANSWER PRESSING QUESTIONS ABOUT HOW TO REDUCE DISPARITIES IN ACCESS, USING SIMULATION MODELING TO EXAMINE WHETHER UNIVERSAL INCREASES IN ACCESS TO EVIDENCE-BASED PRACTICES (EBPS) SUCH AS SCREENING, BRIEF INTERVENTION, AND REFERRAL TO TREATMENT (SBIRT) OR MEDICATION-ASSISTED TREATMENT CAN REDUCE DISPARITIES, OR WHETHER MORE TARGETED EFFORTS TO IMPROVE ACCESS ARE NEEDED TO REACH HIGH-PRIORITY POPULATION SUBGROUPS. SIMULATION MODELS ARE WELL-SUITED FOR IDENTIFYING UNINTENDED CONSEQUENCES OF INTERVENTIONS IMPLEMENTED IN COMPLEX SYSTEMS, AS WELL AS OUTCOMES THAT MAY OCCUR YEARS AFTER IMPLEMENTATION. BY PROJECTING INTERVENTION EFFECTS ACROSS POPULATION SUBGROUPS OVER TIME, SIMULATION MODELING CAN HELP IDENTIFY AND PRIORITIZE TYPES OF ALCOHOL HEALTH SERVICES INTERVENTIONS TO REDUCE AUD DISPARITIES. ALTHOUGH SIMULATION METHODS ARE BEING USED TO ADDRESS THE OPIOID CRISIS, TO DATE THERE IS NO PUBLISHED SIMULATION MODEL COMPREHENSIVELY DESCRIBING THE CONTINUUM OF ALCOHOL HEALTH SERVICES IN RELATION TO AUD DISPARITIES. THE PROPOSED STUDY FILLS THIS GAP BY SIMULATING EFFECTS OF INCREASED ACCESS TO ALCOHOL HEALTH SERVICES ACROSS THE CONTINUUM OF CARE FROM SBIRT, TO SPECIALTY CARE (INCLUDING AUD MEDICATIONS) AND INFORMAL TREATMENT (INCLUDING 12-STEP GROUPS LIKE ALCOHOLICS ANONYMOUS), IN RELATION TO HEALTH DISPARITIES. FIRST, WE WILL BUILD AND CALIBRATE A MICROSIMULATION MODEL OF ALCOHOL HEALTH SERVICES FOR PEOPLE WITH MILD, MODERATE, AND SEVERE AUD, GUIDED BY A CONCEPTUAL MODEL THAT INCLUDES BARRIERS TO TREATMENT AT THE INDIVIDUAL, ORGANIZATIONAL, COMMUNITY, AND POLICY LEVELS. NEXT, WE WILL USE A GEOGRAPHICALLY SITUATED SIMULATED POPULATION REPRESENTING THE LARGE, DEMOGRAPHICALLY AND GEOGRAPHICALLY DIVERSE STATES OF CALIFORNIA AND TEXAS TO MAKE LONG-TERM PROJECTIONS FOR AUD SEVERITY AND RECOVERY FOR KEY POPULATION SUBGROUPS OVER TIME. FINALLY, INFORMED BY THEORIES OF HEALTHCARE ACCESS AND UTILIZATION, WE WILL PROJECT CHANGES IN AUD TREATMENT DISPARITIES UNDER SEVERAL ENHANCED CONDITIONS TO IDENTIFY THE MIX AND DISTRIBUTION OF SERVICES THAT WOULD BEST REDUCE DISPARITIES, AND WE ESTIMATE COSTS AND BENEFITS OF IMPROVED SERVICE ACCESS. STUDY AIMS ARE TO ASSESS EFFECTS OF (1) UNIVERSAL IMPLEMENTATION OF EBPS IN TRADITIONAL AND NON-TRADITIONAL SETTINGS AND (2) IMPROVING ACCESSIBILITY, AVAILABILITY, AFFORDABILITY, AND ACCEPTABILITY OF ALCOHOL HEALTH SERVICES ON DISPARITIES, AND TO (3) ESTIMATE COST AND COST-EFFECTIVENESS OF THESE CHANGES. RESULTS WILL PROVIDE DETAILED INFORMATION TO INFORM SERVICE PLANNING BY STATES, COUNTIES, AND COMMUNITIES TO IMPROVE HEALTH SERVICES, INCLUDING PROJECTIONS FOR HOW AND WHERE TO INTERVENE IN A COST- EFFECTIVE MANNER TO REDUCE THE BURDEN OF AUD AND INCREASE LONG-TERM RECOVERY FOR VULNERABLE POPULATIONS.

STRENGTHENING SYRINGE SERVICES PROGRAMS FOR PEOPLE WHO USE DRUGS - THE U.S. OVERDOSE CRISIS IS SURGING. MORE THAN HALF A MILLION AMERICANS HAVE DIED OF AN OPIOID-RELATED OVERDOSE SINCE 2000. OVER THE PAST 20 YEARS, OPIOID OVERDOSE MORTALITY RATES INCREASED FIVEFOLD, AND IN 2020, THE COVID-19 PANDEMIC ACCELERATED THE CRISIS—APRIL 2021 MARKED THE FIRST TIME IN THE U.S. WHEN OVER 100,000 PEOPLE DIED FROM AN OVERDOSE IN THE LAST YEAR. IN ADDITION, PEOPLE WHO INJECT DRUGS (PWID) IN THE U.S. HAVE FACED DISPROPORTIONATELY HIGH RATES OF HEPATITIS4 AND ENDOCARDITIS5 AND HIV OUTBREAKS.6 PROVIDING PWID SUFFICIENT SUPPLIES FOR STERILE INJECTIONS AND ACCESS TO MEDICATIONS FOR OPIOID USE DISORDER (MOUD) REDUCES HIV7, 8 AND HEPATITIS C TRANSMISSION.9 STUDIES SHOW THAT MOUD ACCESS IS ASSOCIATED WITH SIGNIFICANT AND MEANINGFUL REDUCTIONS IN ALL-CAUSE MORTALITY,10 OVERDOSE MORTALITY,11, 12 AND RISK BEHAVIORS, EVEN AMONG SYRINGE SERVICE PROGRAM (SSP) PARTICIPANTS.11, 13, 14 ADDITIONAL EVIDENCE-BASED INTERVENTIONS FOR ELIGIBLE PWID INCLUDE HEPATITIS A AND B VACCINATIONS15, 16; PRE-EXPOSURE PROPHYLAXIS (PREP); AND TREATMENT FOR PEOPLE LIVING WITH HEPATITIS B17, HEPATITIS C 18 OR HIV.19 SSPS HAVE BEEN THE MAINSTAY FOR COMMUNITY-BASED EFFORTS THAT REACH PWID. THEY PROVIDE EVIDENCE-BASED INTERVENTIONS TO PEOPLE WHO HAVE HISTORICALLY FACED INADEQUATE ACCESS. SSPS PROVIDE ACCESS TO AND DISPOSAL OF STERILE SYRINGES AND INJECTION EQUIPMENT21 AND ARE IDEAL SETTINGS FOR DELIVERING EVIDENCE-BASED INTERVENTIONS FOR PWID—THEIR STAFF ARE CULTURALLY COMPETENT IN PROVIDING SERVICES FOR PWID, WHO ALREADY ENGAGE WITH AND TRUST THESE ORGANIZATIONS TO CARE FOR THEIR HEALTH. PWID REPORT ACCEPTABILITY AND COMFORT WITH ACCESSING SERVICES AT SSPS.22-24 COMPARED WITH PWID WITH LIMITED/NO ACCESS TO SSPS, SSP PARTICIPANTS RECEIVING STERILE INJECTION EQUIPMENT ARE LESS LIKELY TO PRACTICE UNSAFE INJECTIONS.25-27 SSPS ARE PLACES WHERE PARTICIPANTS CAN ACCESS NALOXONE,28 VACCINATIONS,29, 30 TESTING, TREATMENT FOR INFECTIOUS DISEASES, 23, 30-33 MOUD,34-36AND PREP.37 IMPROVED SSP ACCESS CAN MITIGATE HEALTH DISPARITIES EXPERIENCED BY PWID, AND INTEGRATED SERVICE DELIVERY IS THE IDEAL MECHANISM FOR INCREASING THAT ACCESS.38 IT IS IMPERATIVE THAT WE UNDERSTAND THE EXPERIENCES, SCALE, AND CHALLENGES THAT SSPS FACE IN DELIVERING THESE SERVICES. RTI’S PROPOSED TEAM HAS DEVOTED THEIR WORK OVER THE LAST 30 YEARS TO GLOBAL INITIATIVES THAT IMPROVE EQUITABLE ACCESS TO EVIDENCE-BASED INTERVENTIONS FOR PWID. OUR TEAM INCLUDES LEADING EXPERTS WHO ARE EMINENTLY QUALIFIED TO CARRY OUT THE PROPOSED WORK. OUR TEAM HAS IMPLEMENTED AND DISSEMINATED AN ANNUAL NATIONAL SURVEY OF SYRINGE SERVICE PROGRAMS (NSSSP), ACHIEVING ~80% RESPONSE RATES OVER THE LAST 2 ROUNDS. OUR TEAM EXCELS AT CONVENING AND COMMUNICATING TO SSPS FOR VIRTUAL AND IN-PERSON EVENTS. RESPONDING TO COMPONENT 1 OF CDC-RFA-PS22-2208, RTI WILL CONTINUE TO EXPAND THESE PARTNERSHIPS TO SUPPORT A NATIONAL SSP NETWORK. RTI’S TEAM WILL CONDUCT UP TO 40 IN-DEPTH INTERVIEWS ANNUALLY TO IDENTIFY EMERGING COMMUNICATION STRUCTURES, EXPLORE NEW COMMUNICATION MECHANISMS, AND UNDERSTAND OTHER EMERGING ISSUES FACED BY SSPS. RTI’S TEAM WILL OVERSEE IMPLEMENTATION AND USE OF AN ANNUAL NSSSP, LEVERAGING PROCEDURES THAT HAVE HELPED US ACHIEVE AN ~80% RESPONSE RATE IN PRIOR SURVEYS. OUR STRATEGIES TO ASSESS AND IMPROVE COMMUNICATION STRATEGIES WILL ENSURE ALL VOICES ARE HEARD AND WILL CENTER THE VOICES OF PEOPLE WITH LIVED DRUG USE EXPERIENCE, INCLUDING BIPOC AND LGBTQ INDIVIDUALS. OUR APPROACH WILL YIELD ACCESS TO HIGH-QUALITY INFORMATION ABOUT THE CURRENT STATE OF SSP SERVICES IN THE U.S. WE WILL SUPPORT AND STRENGTHEN COMMUNICATION STRUCTURES SUCH THAT THE DISSEMINATION OF SURVEY FINDINGS (AND OTHER EMERGING INFORMATION) REACHES A BROAD AUDIENCE AND OPTIMIZES SERVICE DELIVERY. WORKING CLOSELY WITH THE COMPONENT 2 RECIPIENT AND TECHNICAL ASSISTANCE PROVIDERS, OUR ACTIVITIES WILL CONTRIBUTE TO INCREASED ACCESS TO HARM REDUCTION SERVICES, REDUCING INC

FY2015 LAW ENFORCEMENT CORE STATISTICS PROGRAM (LECS)

THE AIM OF THE NATIONAL NIBRS ESTIMATION PROJECT (NNEP) IS TO PRODUCE NATIONAL AND SUBNATIONAL ESTIMATES OF CRIMES REPORTED TO POLICE AND THEIR ASSOCIATED CHARACTERISTICS BASED ON THE SET OF LAW ENFORCEMENT AGENCIES WHO SUBMIT DATA TO THE UNIFORM CRIME REPORT (UCR) THROUGH THE NATIONAL INCIDENT BASED REPORTING SYSTEM (NIBRS). BEGINNING WITH THE 2021 DATA YEAR, WITH THE SUNSET OF THE SUMMARY REPORTING SYSTEM, THE ESTIMATES PRODUCED THROUGH THE NNEP ARE USED FOR THE OFFICIAL CRIME STATISTICS REPORTED BY THE FBI AND FOR DETAILED REPORTS ON CHARACTERISTICS OF CRIMES REPORTED TO THE POLICED PRODUCED BY THE BUREAU OF JUSTICE STATISTICS. AS THE OFFICIAL STATISTICS ON CRIME REPORTED TO THE POLICE, THE NNEP IS BENEFICIAL TO POLICY MAKERS, LAW ENFORCEMENT AGENCIES, RESEARCHERS, AND THE GENERAL PUBLIC. THE NNEP, WHICH BEGAN IN 2017, HAS COMPLETED THE FIRST TWO PHASES OF DEVELOPMENT: (1) THE DEVELOPMENT OF THE STATISTICAL METHODOLOGY USED TO PRODUCE REPRESENTATIVE ESTIMATES FOR A KEY SET OF NIBRS INDICATORS AT THE NATIONAL AND SUBNATIONAL LEVELS; AND (2) THE CREATION OF AN ESTIMATION SYSTEM, BASED SOLELY ON OPEN-SOURCED SOFTWARE, THAT COMPUTES AND INTEGRATE THE VARIOUS COMPONENTS OF THE STATISTICAL METHODOLOGY NEEDED TO PRODUCE THE NIBRS ESTIMATES. THESE FIRST TWO PHASES, CONDUCTED BY RTI INTERNATIONAL, CULMINATED IN THE PRODUCTION OF THE 2021 UNIFORM CRIME STATISTICS ON THE NUMBER OF OFFENSES AND ARRESTS IN THE UNITED STATES. BEGINNING IN 2022, THE NNEP, WHICH WILL CONTINUE TO BE CONDUCTED BY RTI, WILL SHIFT INTO ITS NEXT PHASE, WHICH WILL HAVE TWO COMPONENTS. THE FIRST OF THESE WILL BE TO MAINTAIN THE CURRENT SYSTEM AND PRODUCE THE 2022 UCR STATISTICS. AS AGENCIES ARE EXPECTED TO CONTINUE TRANSITIONING TO NIBRS, METHODOLOGIES WILL BE ADJUSTED TO MAXIMIZE THE GEOGRAPHIC AREAS FOR WHICH ESTIMATES CAN BE PRODUCED, AND THE ESTIMATION SYSTEM WILL BE OPTIMIZED TO ACCOMMODATE THE INCREASED NUMBER OF INCIDENTS. IN THE SECOND COMPONENT, NEW METHODOLOGIES WILL BE DEVELOPED TO FURTHER ENHANCE THE UTILITY OF THE NIBRS ESTIMATION SYSTEM. THIS COMPONENT WILL CONSIST OF SEVERAL RESEARCH AREAS INCLUDING THE EXPANSION OF THE INDICATORS REPORTED THROUGH THE NNEP; EXPANSION OF THE GEOGRAPHIC AREAS FOR WHICH ESTIMATES ARE PRODUCED; ENHANCEMENTS TO THE ESTIMATION PROCEDURES, INCLUDING HOW BIAS IS ESTIMATED; THE EXPANSION OF NIBRS DATA ELEMENTS THAT CAN BE IMPUTED; AND ADDITIONAL OPTIMIZATION PROCEDURES FOR THE ESTIMATION SYSTEM. WHERE POSSIBLE, THESE ENHANCEMENTS WILL BE BUILT INTO THE ESTIMATION SYSTEM AND INCORPORATED INTO THE 2022 DATA YEAR OR LATER UCR STATISTICS.

THIS EDA INVESTMENT SUPPORTS THE RESEARCH TRIANGLE INSTITUTE (RTI) AND ITS SUB-AWARD, THE STATE SCIENCE AND TECHNOLOGY INSTITUTE (SSTI), WITH ESTABLISHING THE COMMUNITY OF PRACTICE FOR BUILD BACK BETTER REGIONAL CHALLENGE (BBBRC) FINALISTS. THE PROJECT WILL SUPPORT BBBRC PHASE 1 AND PHASE 2 GRANTEES THROUGH THIS NATIONAL COMMUNITY OF PRACTICE. THE RTI AND SSTI AIM TO DEEPEN CONNECTIONS, FOSTER LEARNING, AND ULTIMATELY ACCELERATE INDUSTRY CLUSTER GROWTH BY ENCOURAGING THE TESTING OF NEW STRATEGIES, SHARING INSIGHTS, AND SURFACING BEST PRACTICES WHILE BLENDING THIS SHARED LEARNING ENVIRONMENT WITH TECHNICAL ASSISTANCE (TA) FOR THE GRANTEES. THIS AWARD WILL TAKE PLACE OVER A FIVE-YEAR PERIOD OF PERFORMANCE AND WILL PROVIDE AN ECONOMIC DEVELOPMENT PLANNING FRAMEWORK, PROCESS, AND STRATEGY THAT SUPPORTS THE GRANTEES.

THIS PROJECT IS FOR TWO TYPES OF CONFIDENTIAL, NO-COST TECHNICAL ASSISTANCE TO LIVESTOCK OPERATIONS THAT WILL HELP OPERATORS IDENTIFY AND ADDRESS EN

PILOT PROJECTS FOR MODELS OF INFECTIOUS DISEASE AGENT STUDY (MIDAS)

YOUNG WOMEN-FOCUSED HIV PREVENTION: SEEK & TEST IN NC CLINICS

EXPANSIOIN OF ROUTINE HIV COUNSELING & TESTING AND THE PROVISION OF BASIC

STRENGTHENING HIV STRATEGIC HEALTH MANAGEMENT INFORMATION SYSTEM (HMIS) ACTIVITIE

STRENGTHENING HEALTH MANAGEMENT INFORMATION SYSTEMS, DATA USE AND DATA QUALITY IN THE REPUBLIC OF ZI

NEW AWARD DE-FE0032220 DEPARTMENT OF ENERGY (DOE) WITH RESEARCH TRIANGLE INSTITUTE - TITLED, CARBON CAPTURE PLANT FRONT-END ENGINEERING DESIGN (FEED) STUDY FOR CEMENT MANUFACTURING.

ACCEPTABLE MULTI-USER BIODEGRADABLE EXTENDED RELEASE (AMBER) IMPLANT SYSTEM FOR HIV PREVENTION

A MULTILEVEL COMPREHENSIVE RESPONSE ON UPTAKE AND ADHERENCE TO HIV PREVENTION AMONG ADOLESCENT GIRLS AND YOUNG WOMEN

COMBINATION PREVENTION FOR VULNERABLE WOMEN IN SOUTH AFRICA.

"MULTIMODAL RETROSPECTIVE AND PROSPECTIVE UNIT-LEVEL ANALYSIS OF MILITARY WORKPLACE VIOLENCE"

INTEGRATED SEPARATIONS TO IMPROVE BIOCRUDE RECOVERY FOR BIOFUELS AND BIOPRODUCTS

ENHANCING DISCOVERY OF HIV HOST GENETICS USING DRUG ABUSE AND OTHER INTERACTIONS

ACCELERATING COLORECTAL CANCER SCREENING AND FOLLOW-UP THROUGH IMPLEMENTATION SCIENCE (ACCSIS) PROGRAM

SPEAK TO THE POTENTIAL, ABILITY, AND RESILIENCE INSIDE EVERY KID (SPARK): A MENTORING INTERVENTION FOR MIDDLE-SCHOOL STUDENTS

RTI CHEAR EXPOSURE ASSESSMENT HUB

2/2 MILRINONE FOR PREVENTION OF POST-PATENT DUCTUS ARTERIOSUS CLOSURE SYNDROME IN EXTREMELY PRETERM INFANTS (MIDAS TRIAL) - DCC RESUBMISSION - PROJECT SUMMARY INFANTS BORN PRETERM ARE EXPOSED TO AN ARRAY OF MORBIDITIES. THE MOST COMMON CARDIOVASCULAR PROBLEM OBSERVED IN THIS POPULATION IS PATENT DUCTUS ARTERIOSUS (PDA). FOLLOWING SURGICAL CLOSURE OF A PDA, INFANTS CAN DEVELOP POST-LIGATION CARDIAC SYNDROME (PLCS), A SERIOUS COMPLICATION WHICH REPRESENTS A STATE OF SEVERE POSTOPERATIVE CARDIOPULMONARY INSTABILITY. PLCS CAN BE OBSERVED IN UP TO 50% OF EXTREMELY PREMATURE INFANTS AFTER SURGICAL CLOSURE OF THE PDA. RECOGNITION AND TREATMENT OF PLCS OFTEN OCCURS LATE AND TREATMENT IS VARIABLE ACROSS HOSPITALS. TO DATE, THERE HAVE BEEN NO RANDOMIZED CONTROLLED CLINICAL TRIALS (RCTS) OF CARDIOVASCULAR DRUGS TO EITHER PREVENT OR TREAT PLCS IN PRETERM INFANTS. GIVEN THE VARIANCE IN TREATMENT OF PLCS, THE POTENTIAL USE OF HARMFUL TREATMENTS AMID SUBOPTIMAL EVIDENCE OR SCIENTIFICALLY PROVEN JUSTIFICATION FOR USE, A MASKED, MULTICENTER RANDOMIZED TRIAL IS ESSENTIAL. PRELIMINARY DATA SUGGEST THAT MILRINONE, A COMMONLY USED CARDIOVASCULAR MEDICATION, REDUCES THE RISK OF PLCS IN NEONATES REQUIRING SURGICAL LIGATION FOR PDA. THE PROPOSED MILRINONE FOR PREVENTION OF POST-LIGATION CARDIAC SYNDROME (MIDAS) TRIAL AIMS TO MOVE PRELIMINARY RESEARCH FORWARD BY DESIGNING AND IMPLEMENTING AN RCT TO OBTAIN ADDITIONAL DATA TO DETERMINE EFFICACY OF PROPHYLACTIC MILRINONE AT REDUCING THE INCIDENCE OF PLCS AND IMPROVING NEONATAL OUTCOMES. WE WILL APPLY THE EXPERIENCE AND RIGOR OF THE NEONATAL RESEARCH NETWORK INFRASTRUCTURE IN PERFORMING RANDOMIZED PLACEBO-CONTROLLED TRIALS IN UNION WITH RTI’S LEADERSHIP IN STATISTICAL DESIGN AND ANALYSIS AND NUMEROUS PRIOR SUCCESSES IN THE DEVELOPMENT AND IMPLEMENTATION OF RCTS. THE SPECIFIC AIMS FOR THE MIDAS TRIAL ARE: • SPECIFIC AIM #1: DETERMINE THE EFFICACY OF PROPHYLACTIC MILRINONE ON DECREASING PLCS AND MORTALITY IN EXTREMELY PRETERM INFANTS, BORN AT GESTATIONAL AGE <27 WEEKS AND 6 DAYS, AFTER PDA CLOSURE BY SURGICAL LIGATION OR PERCUTANEOUS CARDIAC CATHETERIZATION. • SUBSIDIARY AIM: DETERMINE THE EFFECTS OF PROPHYLACTIC MILRINONE ON 2-YEAR SURVIVAL AND INCIDENCE OF ADVERSE NEURODEVELOPMENTAL OUTCOMES IN EXTREMELY PRETERM INFANTS TREATED WITH PDA LIGATION. WITH SUCCESSFUL EXECUTION OF THESE PLANNED EXPERIMENTAL AIMS, THE DCC WILL BE ABLE TO CONTRIBUTE TOWARD IDENTIFICATION OF AN EVIDENCE-BASED APPROACH (DEMONSTRATIVE OF EXTERNAL VALIDITY AND REPRODUCIBILITY) FOR THE SAFE PREVENTION AND TREATMENT OF PCLS IN PRETERM INFANTS.

NATIONAL VICTIMIZATION STATISTICAL SUPPORT PROGRAM

INTEGRATING EPIGENOMICS IN HUMAN BRAIN AND GENOMICS OF NICOTINE DEPENDENCE

PHARMACOTHERAPIES FOR ALCOHOL AND SUBSTANCE USE DISORDERS ALLIANCE (PASA4)

INTEGRATED WARM GAS MULTICONTAMINANT CLEANUP TECHNOLOGIES FOR COAL-DERIVED SYNGAS

EVALUATION OF THE FY2011 BUREAU OF JUSTICE ASSISTANCE SECOND CHANCE ACT ADULT OFFENDER REENTRY DEMONSTRATION PROJECTS (FOCUS AREA 2)

GENOME-WIDE ASSOCIATION STUDY OF HIV-1 HOST GENETICS AMONG INJECTION DRUG USERS

BENCH SCALE DEVELOPMENT OF A NON-AQUEOUS SOLVENT CARBON DIOXIDE CAPTURE PROCESS FOR COAL FIRED POWER PLANTS

HARNESSING KNOWLEDGE OF GENE FUNCTION IN BRAIN TISSUE FOR DISCOVERING BIOLOGY UNDERLYING HEROIN ADDICTION

SUBSTANCE ABUSE TREATMENT TO HIV CARE (SAT2HIV)

RESEARCH TRIANGLE INSTITUE (RTI) 3234-1508, DE-FOA-0003234, NEW GREENWELLS TITLE: NEXT-GENERATION FLEXIBLE MODULAR E-METHANOL PRODUCTION

COORDINATING CENTER FOR RESEARCH CENTERS FOR IMPROVING MANAGEMENT OF SYMPTOMS DURING AND FOLLOWING CANCER TREATMENT

POTENTIAL TREATMENT MEDICATIONS FOR DRUG ABUSE

FINDING, TESTING AND TREATING HIGH-RISK PROBATIONERS AND PAROLEES WITH HIV

EVALUATION OF THE HONEST OPPORTUNITY PROBATION WITH ENFORCEMENT DEMONSTRATION FIELD EXPERIMENT (HOPE DFE)

COMPACT, INEXPENSIVE MICRO-REFORMERS FOR DISTRIBUTED GTL

ZOO U INTERVENTION STUDY 2018 (IES GOAL 3)

IMPLEMENTATION RESEARCH FOR VULNERABLE WOMEN IN SOUTH AFRICA