School Foundation Inc

PHSU SPECIALIZED CENTER IN HEALTH DISPARITIES - IMPACT OF COVID-19 ON LIFE EXPERIENCES OF VULNERABLE CHILDREN AND FAMILIES

HEALTH INFORMATION TECHNOLOGY COOPERATIVE REGIONAL CENTER

PONCE SCHOOL OF MEDICINE-MOFFITT CANCER CENTER PARTNERSHIP (1/2)

RCMI PROGRAM AT THE PONCE SCHOOL OF MEDICINE

RECOVERY ACT

PUERTO RICO ENHANCED SURVEILLANCE AND CONTROL OF ARBOVIRUSES (PRESCA) PROGRAM

PONCE SCHOOL OF MEDICINE RCMI PROGRAM

PONCE SCHOOL OF MEDICINE MBRS-RISE PROGRAM

TEACHER QUALITY PARTNERSHIPS GRANTS

SENTINEL ENHANCED DENGUE SURVEILLANCE SYSTEM (SEDSS) SITES TO EVALUATE THE EPIDEMIOLOGY AND PREVENTION OF DENGUE AND OTHER ACUTE FEBRILE ILLNESSES IN

INVESTING IN INNOVATION -- DEVELOPMENT GRANTS

RESEARCH LAB RESTORATION PROGRAM

MENTAL HEALTH CPR: TRANSFORMING CANCER SURVIVORS' MENTAL HEALTH WITH COMMUNITY PARTICIPATORY REACH FOR EQUITY - PROJECT SUMMARY HISPANIC CANCER PATIENTS AND SURVIVORS FACE SOCIAL AND STRUCTURAL INEQUALITIES PERPETUATING MENTAL HEALTH DISPARITIES. DESPITE THESE CHALLENGES, THE STUDY TEAM AND COMMUNITY PARTNERS ARE CONVINCED THAT PSYCHOSOCIAL AND MENTAL HEALTH INEQUITIES PERPETRATED BY SOCIO-ENVIRONMENTAL FACTORS CAN BE OVERCOME THROUGH COMMUNITY- BASED MULTILEVEL INTERVENTIONS; YET NONE CURRENTLY EXIST. THIS PROJECT IS HIGHLY TRANSFORMATIVE AND INNOVATIVE BECAUSE IT DISRUPTS TRADITIONAL PSYCHO-ONCOLOGY MENTAL HEALTH CARE TO ADDRESS UPSTREAM STRUCTURAL (LIMITED ACCESS TO PSYCHOSOCIAL AND MENTAL HEALTH INEQUITIES AND PSYCHOLOGICAL DISTRESS SCREENING), SOCIAL (MENTAL HEALTH STIGMA), AND BIOLOGICAL (STRESS AND INFLAMMATION BIOMARKERS) DETERMINANTS OF MENTAL HEALTH AMONG HISPANIC CANCER PATIENTS AND SURVIVORS. THIS TRANSFORMATION WILL BE ACHIEVED BY SIMULTANEOUSLY INTEGRATING GRASSROOTS (COMMUNITY LEADERS) AND TOP-DOWN (INSTITUTIONAL) RESOURCES TO INCREASE ACCESS TO SPECIALIZED PSYCHO-ONCOLOGY MENTAL HEALTH CARE SERVICES AND PSYCHOLOGICAL DISTRESS SCREENING WHILE ERADICATING MENTAL HEALTH STIGMA. FIRST, THE TEAM WILL TRAIN LAY COMMUNITY LEADERS TO BECOME COMMUNITY HEALTH WORKERS ADDRESSING PSYCHO-ONCOLOGY MENTAL HEALTH PREVENTION EFFORTS. SECOND, THE INVESTIGATORS, ALONG WITH COMMUNITY STAKEHOLDERS, WILL PACKAGE THE PROPOSED MULTILEVEL COMMUNITY-BASED INTERVENTION BY INTEGRATING AND ADAPTING A SUITE OF INDIVIDUAL/COMMUNITY INTERVENTIONS AND SERVICE INITIATIVES PREVIOUSLY DEVELOPED AND IMPLEMENTED BY MEMBERS OF THE RESEARCH TEAM AND PROVEN TO POSITIVELY IMPACT PUERTO RICAN HISPANIC CANCER PATIENTS AND SURVIVORS’ PSYCHOSOCIAL AND MENTAL HEALTH WELLBEING. AT THE COMMUNITY LEVEL, THE TEAM WILL FIRST TRAIN LAY COMMUNITY LEADERS TO BECOME COMMUNITY MENTAL HEALTH WORKERS THROUGH THE PHSU-RCMI COMMUNITY TRAINING INSTITUTE FOR HEALTH DISPARITIES. AT THE INTERPERSONAL LEVEL, THE COMMUNITY-BASED INTERVENTION WILL INTEGRATE FAMILY-COMMUNICATIONS SKILLS TO IMPACT HISPANIC CANCER PATIENTS' AND SURVIVOR FAMILY CAREGIVERS’ SUPPORT QUALITY. AT THE INDIVIDUAL LEVEL, THE INTERVENTION WILL IMPACT ALL PHASES OF THE MENTAL HEALTH PREVENTION CONTINUUM TO PREVENT AND ADDRESS PSYCHOLOGICAL DISTRESS RESULTING FROM CANCER AND ITS TREATMENT. AT THE BIOLOGICAL LEVEL, INVESTIGATORS WILL ASSESS THE EFFECT OF THE COMMUNITY INTERVENTION ON PSYCHOLOGICAL STRESS BIOMARKERS (CORTISOL AND CATECHOLAMINE METABOLITES) AND INFLAMMATION MARKERS (CYTOKINES AND CHEMOKINES) RELATED TO CHRONIC STRESS AND CANCER HEALTH OUTCOMES. THE TEAM ANTICIPATES THIS PROJECT WILL PUSH A TRANSFORMATIVE POPULATION-LEVEL IMPACT THROUGH A MULTILEVEL APPROACH THAT EMPOWERS COMMUNITIES TO UNDERSTAND AND ADDRESS MENTAL HEALTH AMONG INDIVIDUALS.

INVESTING IN INNOVATION - DEVELOPMENT GRANTS

MBRS SCORE PROGRAM AT THE PONCE SCHOOL OF MEDICINE

TARGETING CENTROSOME?MITOTIC KINASES AS A NOVEL THERAPEUTIC APPROACH AGAINST BREAST CANCERS IN HISPANIC/LATINAS. - NON-HISPANIC BLACK (NHB) AND HISPANIC/LATINO (H/L) WOMEN IN THE UNITED STATES (US) HAVE HIGHER PROBABILITIES OF BREAST CANCER-RELATED DEATH THAN NON-HISPANIC WHITE (NHW) WOMEN. H/L WOMEN FROM THE CARIBBEAN (C-H/L, PUERTO RICAN, CUBAN AND DOMINICAN) AND BLACK H/L ARE AT AN EVEN HIGHER RISK OF DEATH THAN H/L FROM OTHER REGIONS AND WHITE H/L. THIS HIGHER RISK IS IN PART DUE TO NHB AND C-H/L WITH BREAST CANCERS BEING MORE LIKELY TO BE DETECTED AT YOUNGER AGES, WITH TUMORS OF HIGHER STAGES AND GRADES, AND WITH TRIPLE-NEGATIVE BREAST CANCERS (ER-PR- AND HER2- OR TNBC). AFRICAN ANCESTRY COMBINED WITH LESS OF THE PROTECTIVE EUROPEAN GENOME GREATLY INFLUENCES THESE RISK FACTORS IN NHB AND C-H/L WOMEN (ON AVERAGE HAVING 79% AND 27% AFRICAN GENOMIC CONTRIBUTION, RESPECTIVELY). CENTROSOME AMPLIFICATION-DRIVEN MITOTIC DYSFUNCTION LEADING TO CHROMOSOME INSTABILITY (CIN) AND ANEUPLOIDY MAY ALSO CONTRIBUTE TO METASTASIS AND POOR CLINICAL OUTCOMES OF THESE TNBC PATIENTS. THE CO-PIS PUBLISHED THAT THE CENTROSOME/MITOTIC KINASES TTK, NEK2, AND TBK1 GENERATE CA/CIN AND THAT TTK AND NEK2 DRIVE THE EPITHELIAL TO MESENCHYMAL TRANSITION (EMT). PRELIMINARY DATA INDICATES THAT TTK, NEK2, AND TBK1 MRNAS ARE DYSREGULATED IN NHB AND TNBCS, AND ARE OVEREXPRESSED IN BREAST TUMORS FROM C-H/L. ALSO, BY USING A NOVEL NCI-BMAP3 REGION BREAST CANCER TISSUE MICROARRAY (TMA) CONTAINING SAMPLES FROM NHW, NHB, AND C-H/L WOMEN, THE CO-PIS FOUND THAT TTK AND PTBK1 ARE OVEREXPRESSED IN TNBC AND TTK CORRELATES WITH EMT IN TNBC. INACTIVATING TTK OR TBK1 RESTORED RB IN TNBC CELLS, SUGGESTING IT CAN RESTORE PALBOCICLIB RESPONSES. CO-INACTIVATING TTK AND TBK1 IN TNBC CELLS REDUCED THE LEVELS OF CENTROSOME/MITOTIC REGULATORS AND EMT MARKERS, AND CO-INACTIVATING TTK/TBK1 OR TTK/NEK2 SIGNIFICANTLY REDUCED THE MIGRATION AND INVASION OF TNBC. THE STUDY TEAM HYPOTHESIZES THAT TTK, NEK2, AND TBK1 DYSREGULATION IN C-H/L AND NHB WOMEN WITH BREAST CANCER (BC) IS DICTATED BY AFRICAN ANCESTRY AND CONTRIBUTES TO THEIR POOR SURVIVAL OUTCOMES BY DRIVING CANCER CELL SURVIVAL AND EARLY METASTASIS. TO TEST THIS HYPOTHESIS, THE TEAM PROPOSES THE FOLLOWING SPECIFIC AIMS: (1) INVESTIGATING SIGNALING PATHWAYS LINKING MITOTIC KINASES TO EARLY METASTASIS AND POOR PROGNOSIS OF NON-HISPANIC BLACK (NHB), CARIBBEAN HISPANIC/LATINO (C-H/L), AND HISPANIC/LATINO (H/L) WOMEN WITH BREAST CANCER. THE TEAM WILL DETERMINE IF RNA EXPRESSION SIGNATURES AND COPY NUMBER VARIATIONS CORRELATE WITH THE EXPRESSION OF MITOTIC KINASES WITH EMT MARKERS, AND SURVIVAL OUTCOMES, USING RNA AND DNA SEQ DONE BY THE ORIEN CONSORTIUM AND A NOVEL TMA DEVELOPED BY THE PUERTO RICO BIOBANK. (2) TO ADDRESS HOW CO-INACTIVATION OF MITOTIC KINASES SUPPRESSES THE MESENCHYMAL STATE, METASTASIS, AND RESTORES PALBOCICLIB RESPONSES IN TNBC CELLS. THIS WILL BE ADDRESSED BY SINGLE AND COMBINATORIAL INHIBITION OF TTK, NEK2, AND TBK1 IN PRIMARY CELL LINES AND PDX MODELS OF TNBC FROM NHB AND H/L WOMEN WITH BREAST CANCER. RESULTS FROM THE PROPOSED EXPERIMENTS WILL HELP REDUCE ETHNIC/RACIAL BREAST CANCER DISPARITIES BY IDENTIFYING ACTIONABLE TARGETS (TTK, NEK2, TBK1, AND OTHER NOVEL KINASES FOUND IN AIM 1) AGAINST THE AGGRESSIVE GROWTH AND EARLY METASTATIC PROGRESSION IN NHB AND H/L WOMEN WITH TNBC.

GRADUATE PSYCHOLOGY EDUCATION PROGRAMS

POST-HURRICANE CANCER CARE: PATIENT NEEDS AFTER HURRICANE MARIA

TRANSITION TO TEACHING PROGRAM -- LOCAL

PURPOSE: THE YOUTH HOMELESSNESS DEMONSTRATION PROGRAM (YHDP) AIMS TO SUPPORT SELECTED COMMUNITIES IN DEVELOPING AND IMPLEMENTING A COORDINATED COMMUNITY APPROACH TO PREVENTING AND ENDING YOUTH HOMELESSNESS. THE POPULATION TO BE SERVED BY THIS DEMONSTRATION PROGRAM IS YOUTH EXPERIENCING HOMELESSNESS, INCLUDING UNACCOMPANIED AND PREGNANT OR PARENTING YOUTH. THE DEMONSTRATION HAS SEVEN PRIMARY OBJECTIVES: • BUILD NATIONAL MOMENTUM. • PROMOTE EQUITY IN THE DELIVERY AND OUTCOMES OF HOMELESS ASSISTANCE. • HIGHLIGHT THE IMPORTANCE OF YOUTH LEADERSHIP. • EVALUATE THE COORDINATED COMMUNITY APPROACH. • EXPAND CAPACITY. • EVALUATE PERFORMANCE MEASURES. • ESTABLISH A FRAMEWORK FOR THE FEDERAL PROGRAM AND TECHNICAL ASSISTANCE COLLABORATION. BEGINNING IN 2016, NEW YHDP COMMUNITIES ARE SELECTED THROUGH A COMPETITIVE PROCESS DEPENDING ON THE ANNUAL FUNDING PROVIDED BY CONGRESS. A MAP OF CURRENTLY FUNDED YHDP SITES IS AVAILABLE AT THE LINK TITLED MAP OF YHDP-FUNDED COC (UNDER YHDP COMMUNITIES) AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/YHDP/.; ACTIVITIES TO BE PERFORMED: ELEVEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE YHDP: 1. ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; 2. REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; 3. NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; 4. LEASING OF A NEW STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; 5. RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; 6. SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; 7. OPERATING COSTS OF SUPPORTIVE HOUSING; 8. COSTS OF IMPLEMENTING AND OPERATING HOMELESS MANAGEMENT INFORMATION SYSTEM (HMIS); 9. PROGRAM ADMINISTRATIVE COSTS; 10. RELOCATION COSTS; AND 11. INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PART 200, AS APPLICABLE. NO ASSISTANCE PROVIDED UNDER THIS PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: AS A RESULT OF DEVELOPING AND IMPLEMENTING A COORDINATED COMMUNITY APPROACH TO PREVENTING AND ENDING YOUTH HOMELESSNESS, THERE WILL BE: • SIGNIFICANT DECREASE IN THE NUMBER OF YOUTH EXPERIENCING HOMELESSNESS. • INCREASED INCOME, EDUCATION, HEALTH, AND SOCIAL/EMOTIONAL WELL-BEING OF PARTICIPANTS. • COMMUNITY-LEVEL UNDERSTANDING OF THE NUMBER AND NEEDS OF YOUTH AT-RISK OF AND EXPERIENCING HOMELESSNESS. • NEW OR IMPROVED PARTNERSHIPS BETWEEN YOUTH-SERVING ORGANIZATIONS IN THE COMMUNITY.; INTENDED BENEFICIARIES: HOMELESS UNACCOMPANIED YOUTH (AGE 24 AND YOUNGER) AND HOMELESS YOUTH (AGE 24 AND YOUNGER) WITH CHILDREN.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

G-RISE AT PONCE HEALTH SCIENCES UNIVERSITY - G-RISE AT PONCE HEALTH SCIENCES UNIVERSITY (PHSU G-RISE): THE OVERALL GOALS OF THE PHSU G-RISE PROGRAM ARE TO INCREASE THE COMPETITIVENESS OF UNDERREPRESENTED HISPANIC STUDENTS GRADUATING FROM THE BIOMEDICAL SCIENCES PHD PROGRAM AT PHSU IN PUERTO RICO AND TO INCREASE THE NUMBER OF HIGHLY QUALIFIED UNDERREPRESENTED STUDENTS WHO ADVANCE TO POSTDOCTORAL POSITIONS AND DIVERSE RESEARCH-RELATED CAREERS. TO ACHIEVE THESE GOALS, WE WILL BUILD UPON THE VERY SUCCESSFUL TRAINING PROGRAM CREATED UNDER THE PREVIOUS R25-RISE FUNDING MECHANISM WHICH HAD A POSITIVE IMPACT ON THE TRAINING OF OUR PHD STUDENTS AND ON THE ENTIRE PHSU COMMUNITY. UNDER THE PRIOR R25-RISE PROGRAM THE PHD COMPLETION RATE INCREASED FROM 73% TO 90% OF R25-RISE TRAINEES, THE AVERAGE TIME TO GRADUATION DECREASED FROM 6.2 TO 5.6 YEARS, AND 64% OF R25-RISE TRAINEES CONTINUED WITH POSTDOCTORAL TRAINING AFTER GRADUATING. OF THE 56 R25-RISE TRAINEES SUPPORTED 21 OBTAINED INDEPENDENT FELLOWSHIPS, 31 ALREADY GRADUATED WITH A PHD AND 8 HAVE SECURED FACULTY POSITIONS. THE PROPOSED PHSU G-RISE APPLICATION WILL BUILD UPON THOSE SUCCESSES AND ADAPT TO SEVERAL IMPORTANT LESSONS LEARNED. IT WILL PROVIDE THE ORGANIZATIONAL STRUCTURE AND EXTENSIVE MENTORING NECESSARY TO ENSURE TRAINEES HAVE A SENSE OF BELONGING AND SCIENTIFIC IDENTITY WHILE EMPOWERING THEM TO PREPARE FOR AND OVERCOME OBSTACLES IN THEIR SCIENTIFIC CAREERS. THE PROGRAM PROPOSES TO ACCOMPLISH THESE GOALS THROUGH ENHANCEMENT OF THE ACADEMIC, RESEARCH, PERSONAL, AND PROFESSIONAL COMPETENCE OF OUR UNDERREPRESENTED MINORITY STUDENTS TO BETTER PREPARE THEM FOR DIVERSE CAREERS IN THE BIOMEDICAL SCIENCES. THE SPECIFIC MEASURABLE OBJECTIVES OF THE PHSU G-RISE PROGRAM ARE TO PROVIDE: (1) PROFESSIONAL, OPERATIONAL, AND TECHNICAL RESEARCH SKILLS TRAINING FOR PHSU G-RISE TRAINEES; (2) COMMUNICATION SKILLS TRAINING FOR PHSU G-RISE TRAINEES; (3) TEAM BUILDING/NETWORKING OPPORTUNITIES FOR PHSU G-RISE TRAINEES; AND (4) INCREASE THE PHD COMPLETION RATE WHILE REDUCING TIME-TO-DEGREE. EACH OF THESE OBJECTIVES WILL BE PURSUED WITH AN EXPERIENCE-BASED BALANCE OF CONTINUING ACTIVITIES THAT WERE HIGHLY EFFECTIVE AS WELL AS A STRATEGIC SET OF NEW TRAINING COMPONENTS THAT WERE DEVELOPED TO ADDRESS THE EMERGING NEEDS OF OUR TRAINEES. THE PHSU G-RISE PROGRAM WILL WORK IN CONCERT WITH THE EXISTING PHSU-MOFFITT CANCER CENTER PARTNERSHIP AND RCMI PROGRAMS TO SIGNIFICANTLY IMPACT THE OVERALL RESEARCH PROGRAM BY PROVIDING A BETTER TRAINED STUDENT WORKFORCE TO CONDUCT THE FUNDED RESEARCH PROJECTS AND PROVIDE THE MOMENTUM TO CREATE NEW RESEARCH INITIATIVES.

NAVY UNDERSTANDING INDUSTRY (NUIC) COURSE

INHERITED GENETIC FACTORS IN BREAST CANCER PREDISPOSITION AND TUMOR PRESENTATION

FACTORS ASSOCIATED WITH VARIABILITY IN DNA REPAIR CAPACITY IN THEIR EFFECT ON BRE

SNP ANALYSIS OF ENDOMETRIOSIS CANDIDATE GENES

PSM MOFFITT CANCER CENTER PARTNERSHIP

INHERITED GENETIC FACTORS IN BREAST CANCER PREDISPOSITION AND TUMOR PRESENTATION

OPIOID WORKFORCE EXPANSION PROGRAM- PROFESSIONAL

TIME RESOLVED SPECTROSCOPY OF INSULATOR METAL TRANSITION: EXPLORING LOW ENERGY DYNAMICS IN STRONGLY CORRELATED SYSTEMS

REDUCTION OF LETHAL PROSTATE CANCER DISPARITIES IN UNDERSERVED HISPANIC/LATINO POPULATIONS

YOUTH BUILD

MOLECULAR EPIDEMIOLOGY STUDIES ON THE ROLE OF DNA REPAIR BREAST CANCER

THE MATCH FOUNDATION, INC. PROPOSES TO HAVE 45 AMERICORPS MEMBERS WHO WILL TUTOR STUDENTS IN HIGH-POVERTY PUBLIC SCHOOLS IN BOSTON, MASSACHUSETTS AND BALTIMORE, MARYLAND. AT THE END OF THE FIRST PROGRAM YEAR, THE AMERICORPS MEMBERS WILL BE RESPONSIBLE FOR INCREASING STUDENT PERFORMANCE IN MATHEMATICS, IMPROVING EDUCATIONAL OUTCOMES FOR ECONOMICALLY DISADVANTAGED CHILDREN AND SUPPORTING ECONOMICALLY DISADVANTAGED STUDENTS IN PREPARING FOR SUCCESS IN POST-SECONDARY EDUCATIONAL INSTITUTIONS. THE PROGRAM WILL FOCUS ON THE CNCS FOCUS AREA OF EDUCATION. THE CNCS INVESTMENT OF $427,500 WILL BE MATCHED WITH $589,725 IN PUBLIC FUNDING AND $20,000 IN PRIVATE FUNDING.

YOUTH BUILD

YOUTH BUILD

ORIGIN OF SEMINAL VIRUS IN HUMAN IMMUNODEFICIENCY VIRUS INFECTION

IIJA: MOSIER COMMUNITY SCHOOL: ENERGY EFFICIENCY AND RENEWABLES PROJECT

CK25-182 - PUERTO RICO ENHANCED SURVEILLANCE AND CONTROL OF ENDEMIC AND EMERGING ARBOVIRUSES

REDUCING SERIOUS MENTAL ILLNESS AND SUICIDE STIGMA AMONG MEDICAL STUDENTS.

THE ENTERIC GLIA AS A POSSIBLE TARGET FOR SYMPTOM RELIEF IN ENDOMETRIOSIS - ENDOMETRIOSIS, A CHRONIC PAINFUL GYNECOLOGICAL DISORDER DEFINED AS THE PRESENCE OF ENDOMETRIAL GLANDS AND STROMA OUTSIDE THE ENDOMETRIAL CAVITY, IS CHARACTERIZED BY PERITONEAL INFLAMMATION, FIBROSIS, ADHESIONS, AND OVARIAN CYSTS. WOMEN WITH ENDOMETRIOSIS OFTEN PRESENT GASTROINTESTINAL SYMPTOMS INDEPENDENT OF LESION LOCALIZATION. ENTERIC GLIAL CELLS (EGCS) ARE ASTROCYTE-LIKE CELLS THAT ARE VITAL TO THE ENTERIC NERVOUS SYSTEM AND PLAY A ROLE IN GUT DISEASES. THE ROLE OF INTESTINAL GLIA IN ENDOMETRIOSIS IS UNKNOWN; HOWEVER, A BIDIRECTIONAL RELATIONSHIP BETWEEN THE EGC AND IMMUNE CELLS IN THE MODULATION OF THE INFLAMMATORY RESPONSE AND PAIN SENSITIZATION IS POSTULATED. ENTERIC GLIA CAN PRODUCE AN ENDOGENOUS LIGAND FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPAR) WITH ANTI-INFLAMMATORY ACTIVITY. PPAR AGONISTS IN ENDOMETRIOSIS ANIMAL MODELS REDUCE VESICLE SIZE. THE STUDY TEAM’S PREVIOUS WORK HAS DEMONSTRATED THAT EXERCISE CAN INCREASE EXPRESSION AND ACTIVITY OF PPAR, WHILE REDUCING VESICLE SIZE AND DEVELOPMENT. THE MAIN OBJECTIVE IS TO EXAMINE THE ROLE OF EGC IN THE PATHOPHYSIOLOGY OF ENDOMETRIOSIS WITH THE LONG-TERM GOAL OF FINDING NEW THERAPEUTIC TARGETS. THE STUDY TEAM HYPOTHESIZES THAT ENDOMETRIOSIS-INDUCED IMMUNE ACTIVATION IS REGULATED BY ECG WHICH PROMOTES AND MAINTAINS CHRONIC INFLAMMATION, AND THAT THIS CAN BE REVERSED BY NON-PHARMACOLOGICAL COMPLEMENTARY INTERVENTIONS. AIM 1 WILL DETERMINE HOW ENDOMETRIOSIS IMPACTS THE ENTERIC GLIA AND HOW THIS CORRELATES WITH PAIN. AIM 2 WILL ELUCIDATE WHETHER THE BENEFICIAL EFFECTS OF INTERVENTIONS, SUCH AS EXERCISE AND ENVIRONMENTAL ENRICHMENT, ARE MEDIATED BY PPAR. RATIONALE: COMPLEMENTARY INTERVENTIONS WILL IMPACT THE ENTERIC GLIA VIA PARASYMPATHETIC ACTIVATION, SHIFTING IT FROM THE ENDOMETRIOSIS-INDUCED, PRO-INFLAMMATORY PHENOTYPE TO AN ANTI-INFLAMMATORY ONE, DECREASING PROINFLAMMATORY CYTOKINE RELEASE AND OXIDATIVE STRESS. SUCCESSFUL OUTCOMES COULD EXPLAIN CHRONIC PELVIC INFLAMMATION AND GASTROINTESTINAL SYMPTOMS AND PROVIDE A NOVEL TARGET. THIS STUDY WILL CONTRIBUTE TO THE GOALS OF THE SURE PROGRAM BY SUSTAINING THE RESEARCH EXCELLENCE OF THE PI AND STRENGTHENING THE INSTITUTIONAL RESEARCH ENVIRONMENT. THIS STUDY WILL PROVIDE GRADUATE AND UNDERGRADUATE STUDENTS AT VARIOUS LEVELS WITH OPPORTUNITIES IN MULTIDISCIPLINARY RESEARCH AREAS TO ENCOURAGE THEIR CONTINUED INVOLVEMENT IN BIOMEDICAL SCIENCES RESEARCH AND STIMULATE THEIR INTEREST IN NOVEL INTEGRATIVE INTERVENTIONS.

EVALUATION OF DENGUE EPIDEMIOLOGY, OUTCOMES AND PREVENTION IN SENTINEL SURVEILLAN

UVA-DARDEN WILL PROVIDE 2 RESIDENTIAL EXECUTIVE-LEVEL BUSINESS EDUCATION COURSES SO AS TO UNDERSTAND THE OPERATION AND WORKINGS OF AMERICAN BUSINESS

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING (BHWET) PROGRAM

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING (BHWET) PROGRAM

THIS EDA INVESTMENT SUPPORTS THE IMPLEMENTATION OF THE COALFIELDS WORKFORCE CONSTRUCTION TRAINING PROGRAM (CWCT), TO PROVIDE WORKFORCE TRAINING IN A REGION HIT HARDEST BY THE DOWNTURN IN THE COAL INDUSTRY AND THE COVID-19 PANDEMIC. THE PROJECT WILL HELP THE REGION PREPARE FOR UPWARD MOBILITY AND PROVIDE NEW CERTIFICATIONS FOR THOSE WHO HAVE BEEN DISPLACED FROM THE WORKFORCE OR ARE POSITIONED FOR RE-ENTRY INTO SPECIALTY TRADE FIELDS SUCH AS PLUMBING, ELECTRICIAN, OR HVAC TECHNICIAN. ONCE COMPLETED, THE PROJECT WILL CREATE AND RETAIN JOBS, BOOST ECONOMIC DEVELOPMENT, DIVERSIFY THE LOCAL ECONOMY, AND ADVANCE ECONOMIC RESILIENCY THROUGHOUT THE REGION.

STRESS: POTENTIAL IMPACT ON AN ANIMAL MODEL OF ENDOMETRIOSIS

NAVY UNDERSTANDING INDUSTRY COURSE (NUIC) FOR THE OFFICE OF THE DEPUTY ASSISTANT SECRETARY OF THE NAVY FOR ACQUISITION AND PROCUREMENT (DASN A&P)

DASN NUIC COURSE

ENRICHED ENVIRONMENTS: A MULTI-LEVEL INTEGRATIVE MEDICINE INTERVENTION FOR ENDOMETRIOSIS

ADRENERGIC SIGNALING INHIBITION TO ENHANCE THE IMMUNOGENICITY OF THE OVARIAN TUMOR MICROENVIRONMENT PRIOR TO PD-1 CHECKPOINT THERAPY

NAVY UNDERSTANDING INDUSTRY COURSE (NUIC) FOR THE OFFICE OF THE DEPUTY ASSISTANT SECRETARY OF THE NAVY FOR ACQUISITION AND PROCUREMENT (DASN A&P)

FEAR MODULATION OF IL EXCITABILITY

SUPPRESSION OF MUTAGENESIS WITH ANTIOXIDANTS

PHYSICAL ACTIVITY AS A THERAPEUTIC INTERVENTION IN ENDOMETRIOSIS

FKBP5 MODULATION OF PREFRONTAL FUNCTION.

JANUARY 2018 - COURSE

ASTROCYTIC HIV NEF CAUSES LEARNING IMPAIRMENT VIA INFLAMMATION AND TGF SIGNALING

DEFINING BREAST CANCER RISK: THE ROLE OF GENETIC VARIATIONS IN DNA REPAIR GENES

APPLYING IN VITRO RECORDING TECHNIQUES TO EXTINCTION OF CONDITIONED FEAR

THE ROLE OF TRANSGENDER EMBODIMENT ON BREAST AND UTERINE CERVIX CANCER SCREENING

PUBLIC CHARTER SCHOOLS

CAREGIVERS-PATIENTS SUPPORT TO LATINX COPING WITH ADVANCED-CANCER - PROJECT SUMMARY THE GOAL OF THIS K08 IS TO PREPARE THE PI, TO RECEIVE HANDS-ON EXPERIENCE IN IMPLEMENTATION AND DISSEMINATION, DESIGNING AND LEADING RANDOMIZED CONTROLLED TRIALS (RCTS) IN PALLIATIVE CARE, AND IMPROVE GRANT WRITING SKILLS TO BECOME AN INDEPENDENT R01-FUNDED INVESTIGATOR. HISPANIC/LATINX (H/L) COMMUNITIES EXPERIENCE DISPARATE GENERAL HEALTH OUTCOMES AND ARE MORE LIKELY TO BE DIAGNOSED WITH ADVANCED CANCER WHEN COMPARED TO NON-H/L POPULATIONS. H/L PATIENTS EXPERIENCING ADVANCED CANCER AND THEIR CAREGIVERS ARE AT AN INCREASED RISK FOR UNMET PSYCHOSOCIAL NEEDS; THIS K08 WILL ALLOW THE PI TO FOCUS ON THIS IMPORTANT GAP IN MINORITY HEALTH CARE. THE RESEARCH GOAL OF THIS PROPOSAL IS TO REFINE AND PILOT AN INTERVENTION TITLED: CAREGIVERS PATIENTS SUPPORT TO LATINX COPING WITH ADVANCED CANCER (CASA), A FIVE-SESSION, 60-MINUTE EACH TELEHEALTH SERIES FOR PATIENT-CAREGIVER DYADS. THE LONG-TERM TRAINING GOAL OF THIS APPLICATION IS TO ENABLE THE APPLICANT (PI) TO BECOME AN INDEPENDENT INVESTIGATOR AS A CULTURAL ADAPTATION EXPERT ON PSYCHOSOCIAL INTERVENTIONS IN HEALTH DISPARITY RESEARCH. THE RATIONALE FOR THIS PROJECT IS THAT IT WILL LAY THE GROUNDWORK FOR A RANDOMIZED CONTROL TRIAL (RCT) TESTING THE EFFICACY OF CASA. IT WILL ALSO ASSESS THE IMPLEMENTATION OF AN INNOVATIVE METHOD TO DELIVER THE CASA INTERVENTION. THIS STUDY AIMS TO USE THE COLLABORATIVE INTERVENTION PLANNING FRAMEWORK AND ORBIT MODEL TO MODIFY AND ASSESS THE FEASIBILITY AND PRELIMINARY EFFECT OF THE CASA INTERVENTION. THE OVERALL IMPACT OF THIS STUDY IS TO IMPROVE ACCESS TO PSYCHOSOCIAL, CULTURALLY ADAPTED INTERVENTIONS AMONG H/L PATIENTS AND CAREGIVERS COPING WITH ADVANCED CANCER. THE SPECIFIC AIMS ARE AS FOLLOWS: AIM 1. USE A COLLABORATIVE INTERVENTION PLANNING FRAMEWORK WITH PROVIDERS AND COMMUNITY STAKEHOLDERS TO REFINE STUDY PROCEDURES PRIOR TO THE IMPLEMENTATION OF A PILOT RANDOMIZED CONTROLLED TRIAL. AIM 2: TO TRAIN COMMUNITY MEMBERS AS PATIENT RECRUITERS AND CLINICAL PSYCHOLOGY DOCTORAL STUDENTS AS INTERVENTIONISTS OF THE CASA INTERVENTION. AIM 3: TO IMPLEMENT A PILOT RANDOMIZED CONTROLLED TRIAL TO EVALUATE THE FEASIBILITY, ACCEPTABILITY, AND POTENTIAL EFFICACY OF THE CASA INTERVENTION WITH HISPANIC/LATINX DYADS COPING WITH CANCER.

GRANTS TO IMPROVE THE MENTAL HEALTH OF CHILDREN

RURAL SELF-HELP HOUSING TECHNICAL ASSIST

SYNERGISTIC NEUROTOXICITY OF SPEEDBALL AND HIV TOXINS

EXECUTIVE DEVELOPMENT COURSE

2 WEEK EXECUTIVE DEVELOPMENT COURSE, IIMC

IMPACT AID PROGRAM TITLE VIII SECTION 8002

IMPACT AID PROGRAM, TITLE VIII, SECTION 8002

IMPACT AID PROGRAM, TITLE VIII, SECTION 8002

IMPACT AID PROGRAM, TITLE VIII, SECTION 8002

IMPACT AID PROGRAM, TITLE VIII, SECTION 8002

PRE-K EXPANSION AT CICS: CREATING A MODEL FOR ILLINOIS’S MOVE TOWARDS UNIVERSAL PRE-K

IMPACT AID PROGRAM TITLE VIII SECTION 8002

IMPACT AID PROGRAM TITLE VIII SECTION 8002

IMPACT AID PROGRAM TITLE VIII SECTION 8002

PREFRONTAL MODULATORS OF STRESS-INDUCED EXTINCTION IMPAIRMENT IN FEMALE RATS - PROJECT SUMMARY ABSTRACT: ALTHOUGH WOMEN HAVE TWICE THE INCIDENCE OF DEVELOPING POST-TRAUMATIC STRESS DISORDER (PTSD), THE IDENTIFIED NEUROBIOLOGICAL MECHANISMS THAT INCREASE THE SUSCEPTIBILITY OF FEMALE ANIMALS TO STRESS-INDUCED FEAR EXTINCTION IMPAIRMENT ARE LIMITED. ABUNDANT STUDIES SHOW THAT THE INFRALIMBIC CORTEX (IL) IS CRITICAL FOR PROPER FEAR EXTINCTION RECALL. TO BEGIN TO ADDRESS THIS GAP, ADULT FEMALE RATS WERE EXPOSED TO SINGLE PROLONGED STRESS (SPS) AND THE ANIMALS THAT SHOWED IMPAIRED EXTINCTION RECALL WERE IDENTIFIED. THE RATS THAT WERE SUSCEPTIBLE TO STRESS-INDUCED EXTINCTION IMPAIRMENT EXHIBITED DISTINCT PROTEOMIC CHANGES IN IL COMPARED TO RATS THAT SHOWED GOOD EXTINCTION RECALL. ALTHOUGH MANY OF THE IDENTIFIED PROTEINS, INCLUDING NEUROGRANIN AND MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT), ARE INVOLVED IN NEURONAL FUNCTION AND SYNAPTIC PLASTICITY, THEIR ROLE IN STRESS-INDUCED EXTINCTION IMPAIRMENT IS UNKNOWN. IN THIS PROPOSAL, WE WILL BUILD ON OUR PRELIMINARY FINDINGS TO FURTHER VALIDATE THE PROTEOMIC FINDINGS AND EXAMINE THE ROLE OF IL NEUROGRANIN AND MAPT IN SUSCEPTIBILITY TO IMPAIRED EXTINCTION RECALL AFTER EXPOSURE TO TRAUMATIC STRESS IN FEMALE RATS. THE GOAL OF THIS PROPOSAL IS TO COMPARE, THROUGH ROBUST EXPERIMENTATION, THE MECHANISMS BY WHICH PREFRONTAL NEUROGRANIN AND MAPT EXPRESSION CONTRIBUTE TO IMPAIRED FEAR EXTINCTION AFTER TRAUMATIC STRESS IN FEMALE RATS AS AN IMPORTANT STEP TOWARD UNDERSTANDING PREFRONTAL MECHANISMS THAT ALTER SUSCEPTIBILITY TO IMPAIRED EXTINCTION AFTER EXPOSURE TO TRAUMATIC STRESS IN FEMALES. OUR CENTRAL HYPOTHESIS IS THAT EXPOSURE TO TRAUMATIC STRESS ALTERS NEUROGRANIN OR MAPT EXPRESSION IN THE IL OF SUSCEPTIBLE RATS LEADING TO REDUCED EXCITABILITY OF IL NEURONS AND IMPAIRED FEAR EXTINCTION RECALL IN FEMALES. TO ADDRESS THIS HYPOTHESIS, THE TEAM WILL EXAMINE THE RELATIONSHIP BETWEEN IL NEUROGRANIN AND MAPT EXPRESSION AND IMPAIRED FEAR EXTINCTION AFTER SPS EXPOSURE IN AIM 1. IN AIM 2, THEY WILL DETERMINE IF REDUCING THE EXPRESSION OF NEUROGRANIN OR MAPT IN IL ENHANCES FEAR EXTINCTION AND ALTERS IL NEURONAL EXCITABILITY. THE OVERALL IMPACT OF THESE AIMS WILL GREATLY INCREASE THE UNDERSTANDING OF THE MECHANISMS BY WHICH EXPOSURE TO TRAUMATIC STRESS CAN HINDER FEAR EXTINCTION AND HIGHLIGHT THE ROLE OF CHANGES IN NEUROGRANIN, MAPT, AND THE IL PROTEOME IN THIS PROCESS. THIS DATA WILL ENHANCE NIH’S MISSION TO IDENTIFY THE NEUROBIOLOGICAL BASIS FOR COMPLEX BEHAVIORAL RESPONSES TO TRAUMA AND POTENTIALLY LEAD TO NOVEL TREATMENTS.

FIE EARMARK GRANT AWARDS

PILOT STUDY TO PREVENT TRANSITION FROM OVERWEIGHT TO OBESITY AMONG YOUNG OVERWEIGHT COLLEGE STUDENTS IN PONCE, PUERTO RICO

RURAL HOUSING PRESERVATION GRANTS

RECOVERY ACT GREEN JOBS

THE ROLE OF LOX AND LOXL1 IN THE PATHOPHYSIOLOGY OF ENDOMETRIOSIS

COMBINED ROLE OF HIV-1 TAT AND OPIOID IN NEUROPATHOGENESIS

MOLECLAR REGULATION OF HIV-1 NEF NEUROPATHOGENESIS BY TRANSFORMING GROWTH FACTOR BETA

THE EFFECTS OF STRESS ON THE PATHOPHYSIOLOGY OF ENDOMETRIOSIS

THE ROLE OF RELIGION ON HIV/AIDS STIGMA MANIFESTATIONS AMONG PUERTO RICANS NURSES

EXEMPLARY CHARTER SCHOOL COLLABORATION

COMMUNITY FACILITY GRANTS - COMMUNITY FACILITY

HIPPOCAMPAL ROLE IN EXTINCTION INDUCED PREFRONTAL PLASTICITY

INTERACTION OF HIV-1 NEF AND GLUTAMATE HOMEOSTASIS IN THE NUCLEUS ACCUMBENS DURING COCAINE ADDICTION - SUMMARY THE RECREATIONAL USE OF COCAINE CAN LEAD TO AN ADDICTION THAT INCREASES THE RISK OF ACQUIRING THE HUMAN IMMUNODEFICIENCY VIRUS (HIV) THROUGH HIGH-RISK BEHAVIORS SUCH AS AN INCREASE IN UNPROTECTED SEXUAL ACTIVITY, AND A MORE RAPID PROGRESSION TO AIDS. APPROXIMATELY 33% OF THE 1.2 MILLION PEOPLE IN THE UNITED STATES (US) LIVING WITH HIV USE ILLICIT SUBSTANCES, AND APPROXIMATELY 1 IN 10 NEW HIV DIAGNOSES ARE ATTRIBUTED TO INJECTION DRUG USERS EVERY YEAR. PEOPLE LIVING WITH HIV WHO TAKE COMBINATION ANTIRETROVIRAL THERAPY (CART) AND MAINTAIN VIRAL LOADS BELOW DETECTABLE LEVELS LIVE A NEAR-NORMAL LIFESPAN. HOWEVER, DESPITE THE ADVANCES IN EFFICACIOUS MEDICATION, THERE ARE STILL NO MEDICATIONS THAT PREVENT THE VIRAL INVASION TO THE CENTRAL NERVOUS SYSTEM (CNS) SOLIDIFYING THAT THE RISK OF DEVELOPING HIV-1 ASSOCIATED NEUROCOGNITIVE DISORDERS (HAND) HAS NOT DECREASED. THEREFORE, TO PROTECT CHRONICALLY INFECTED PEOPLE FROM THE RAVAGES OF HIV-1 INFECTION IN THE BRAIN, PARTICULARLY WHEN COMBINED WITH SUBSTANCE USE DISORDER (SUD), IT IS NECESSARY TO ADVANCE THE UNDERSTANDING OF THE INTERSECTION OF HIV-1 AND ADDICTION TO IDENTIFY NOVEL THERAPEUTIC TARGETS. BOTH COCAINE AND HIV PROTEINS CONTRIBUTE TO NEURONAL DAMAGE DURING DISEASE PROGRESSION THROUGH DYSREGULATION OF GLUTAMATE HOMEOSTASIS IN THE BRAIN. IT HAS BEEN DOCUMENTED THAT AS HIGH AS 19% OF ASTROCYTES IN THE BRAINS OF PATIENTS WITH SEVERE HAND ARE INFECTED WITH HIV-1. NEF IS ONE OF THE EARLIEST EXPRESSED VIRAL PROTEINS IN APPROXIMATELY 1% OF INFECTED ASTROCYTES. EVEN WITHOUT MEASURABLE VIRAL REPLICATION, NEF COULD CONTRIBUTE TO CONTINUED NEURONAL DEGENERATION EVEN IN PATIENTS ON CART. EXTRACELLULAR GLUTAMATE IS NORMALLY TAKEN UP BY ASTROCYTES THROUGH A GLUTAMATE TRANSPORTER (GLT-1) AND EXCHANGED FOR CYSTEINE THROUGH THE CYSTINE/GLUTAMATE EXCHANGER. SS -CATENIN, A DUAL FUNCTION PROTEIN, REGULATES THE EXPRESSION OF GLUTAMATE TRANSPORTERS PREVENTING NEUROTOXICITY CAUSED BY EXCESS NMDA RECEPTOR ACTIVATION IN NEURONS. HOWEVER, COCAINE DOWNREGULATES GLT-1 AND THE CYSTINE/GLUTAMATE EXCHANGER. DURING WITHDRAWAL OF COCAINE EXPOSURE, THE AMPA/NMDA RATIO INCREASES IN THE NUCLEUS ACCUMBENS (NAC). THE NAC IS AN IMPORTANT BRAIN STRUCTURE INVOLVED IN THE DEVELOPMENT OF COCAINE ADDICTION. THE OVERALL OBJECTIVE IS TO STUDY THE INTERACTION BETWEEN HIV-1 NEF AND COCAINE RELATED TO GLUTAMATE HOMEOSTASIS AND DRUG-SEEKING BEHAVIOR. THE CENTRAL HYPOTHESIS IS THAT COMBINED COCAINE EXPOSURE AND ASTROCYTIC NEF EXPRESSION WILL EXACERBATE GLUTAMATE EXCITATION INDUCING NEUROPHYSIOLOGICAL CHANGES THAT STRENGTHEN SYNAPTIC TRANSMISSION AND REINFORCE THE COCAINE-SEEKING BEHAVIOR. TO ADDRESS THIS HYPOTHESIS, THE TEAM WILL DEVELOP THE FOLLOWING TWO SPECIFIC AIMS. AIM 1: DETERMINE THE IMPACT OF HIV-1 NEF AND COCAINE ON GLUTAMATERGIC NEUROTRANSMISSION. AIM 2: DETERMINE THE IMPACT OF HIV-1 NEF ON COCAINE-SEEKING BEHAVIOR IN RATS. WITH THE COMBINATION OF IN VIVO SELF-ADMINISTRATION, ELECTROPHYSIOLOGY, AND MOLECULAR STUDIES USING BRAIN TISSUE, THE TEAM WILL ELUCIDATE THE ROLE OF HIV-1 NEF ON COCAINE-SEEKING AND CONSUMPTION ESSENTIAL TO DEVELOPING NEW THERAPIES TO TREAT PEOPLE WITH HIV AND SUD.

STUDENTS IN GRADES K-6 WILL ENGAGE IN 100 OUTDOOR EDUCATION EXPERIENCES WITH COMMUNITY PARTNERS IN THE WAIMANALO WATERSHED. TEACHERS AND COMMUNITY PARTNERS WILL COLLABORATIVELY PRODUCE INTEGRATED CULTURE, PLACE, AND INQUIRY BASED CURRICULUM THAT MOTIVATES STUDENTS TO AUTHENTICALLY LEARN ABOUT SCIENTIFIC PHENOMENA. THE PROGRAM'S DESIGN WHICH INTEGRATES CULTURE, PLACE, COMMUNITY, AND SCIENCE THROUGH STUDENT DRIVEN PROJECTS CREATES A MEANINGFUL WATERSHED EDUCATIONAL EXPERIENCE THAT INCREASES THE STUDENTS' UNDERSTANDING AND THEIR MOTIVATION TO CONTINUE TO TAKE CARE OF THEIR LOCAL WATERSHED IN YEARS TO COME. STUDENT-COMMUNITY RELATIONSHIPS WILL BE ESTABLISHED AND FOSTERED TO PROMOTE LIFELONG LEARNING AND DEDICATION TO WATERSHED RESILIENCE THROUGH THE DEVELOPMENT OF 75 UNIQUE STUDENT-DRIVEN CAPSTONE WATERSHED PROJECTS WHERE 7TH & 8TH GRADE STUDENTS WORK ALONGSIDE COMMUNITY PARTNER ORGANIZATIONS FOR A TOTAL OF OVER 4,800 MAN HOURS.

RURAL HOUSING PRESERVATION GRANTS

RURAL HOUSING PRESERVATION GRANTS

RURAL HOUSING PRESERVATION GRANTS

RURAL HOUSING PRESERVATION GRANTS

DISSECTING THE ROLE OF AMYGDALO-STRIATAL CIRCUITS IN THE REGULATION OF STRESS AND COCAINE COMORBIDITY IN RATS - SUMMARY/ABSTRACT GENERALLY, POST TRAUMATIC STRESS DISORDER (PTSD) AND SUBSTANCE USE DISORDER (SUD) ARE EXAMINED SEPERATELY IN PRECLINICAL STUDIES, ALTHOUGH THEY CAN OCCUR SIMULTANEOUSLY IN PATIENTS. THEREFORE, IT IS NECESSARY TO OBSERVE THESE TWO DISORDERS CLOSELY TOGETHER TO BETTER UNDERSTAND THE MECHANISMS THAT UNDERLIE THIS COMORBIDITY AND THE EFFECTS ON THE NEUROPHYSIOLOGY. ONE OF THE MAIN PROBLEMS IN ADDICTION IS THE HIGH RELAPSE RATE WHEN THE PATIENT IS EXPOSED TO ENVIRONMENTAL CUES OR OTHER FACTORS THAT CAN TRIGGER MEMORIES ASSOCIATED WITH ADDICTION. PRESENTLY, ONE OF THE FACTORS ASSOCIATED WITH A HIGH RELAPSE STATE IS STRESS. EXPOSURE TO A STRESSFUL OR TRAUMATIC EVENTS CAN LEAD TO THE DEVELOPMENT OF PTSD. MOREOVER, PTSD PATIENTS EXHIBIT HIGHER RATES OF SUD. TWO IMPORTANT BRAIN STRUCTURES INVOLVED IN THE DEVELOPMENT OF THESE DISORDERS ARE THE BASOLATERAL AMYGDALA (BLA) AND THE NUCLEUS ACCUMBENS ( NAC). THE BLA CONCERNS THE DEVELOPMENT OF FEAR MEMORIES AND PTSD, WHILE THE NAC IS PART OF THE REWARD CIRCUITRY AND PLAYS AN IMPORTANT ROLE IN THE PROGRESSION OF SUD. THIS NAC IS SUB-DIVIDED IN TWO MAIN REGIONS: THE CORE AND THE SHELL. STUDIES HAVE SHOWN THAT THE CORE DRIVES COCAINE-SEEKING BEHAVIOR WHILE THE SHELL MODULATES EXTINCTION, DECREASING COCAINE-SEEKING BEHAVIOR. IMPORTANTLY, THE INHIBITION OF BLA-NAC SYNAPSES LEADS TO A DECREASE IN OVERALL DRUG SEEKING BEHAVIOR, BUT THE EFFECTS OF CHRONIC STRESS ON THESE SYNAPSES ARE STILL UNKNOWN. THE OBJECTIVE IS TO DISSECT THE MECHANISM BY WHICH BLA MODULATES THE NAC IN A COMBINED ANIMAL MODEL OF PTSD AND SUD. THIS WILL HELP TO BETTER UNDERSTAND HOW ONE DISORDER INFLUENCES THE OTHER. THE CENTRAL HYPOTHESIS IS THAT CHRONIC STRESS WILL INDUCE NEUROPHYSIOLOGICAL CHANGES TO THE BLA-NAC CORE AND SHELL SYNAPSES, WHICH WILL CORRELATE WITH INCREASED COCAINE-SEEKING BEHAVIORS. TO ADDRESS THIS, THE TEAM PROPOSED THE FOLLOWING AIMS: AIM 1: DETERMINE THE EFFECTS OF CHRONIC STRESS ON THE NEUROPHYSIOLOGY OF SYNAPSES OF THE BASOLATERAL AMYGDALA AND NUCLEUS ACCUMBENS PRIOR TO COCAINE EXPOSURE. AIM 2: DETERMINE THE EFFECTS OF OPTICAL ACTIVATION OF BLA-NAC SHELL AND CORE SYNAPSES INDEPENDENTLY ON COCAINE-SEEKING BEHAVIOR IN RATS WITH CHRONIC STRESS PRIOR TO COCAINE EXPOSURE. THE OVERALL GOAL IS TO UNDERSTAND HOW THE CHRONIC STRESS INDUCED NEUROPHYSIOLOGICAL CHANGES IN A RODENT CORRELATE WITH COCAINE SEEKING-BEHAVIOR CHANGES PRIOR TO COCAINE EXPOSURE. THE LONG-TERM GOAL IS TO UNDERSTAND THE MECHANISMS AND ADAPTATIONS OF THE BRAIN CAUSED BY A TRAUMATIC EVENT THAT LEADS TO THE DEVELOPMENT OF PTSD AND THE SUSCEPTIBILITY OF ACQUIRING SUD.

ROLE OF IKBKE IN STRESS-INDUCED OVARIAN CANCER PROGRESSION

THE TIDEWATER ROOTS POLLING PROJECT

RURAL HOUSING PRESERVATION GRANTS

THE ROLE OF THE CXCR4/CXCL12 AXIS IN ENDOMETRIOSIS

RURAL HOUSING PRESERVATION GRANTS

ROLES OF E2F3 AND SGO1 IN THE EPITHELIAL-TO-MESENCHYMAL TRANSITION AND METASTASIS OF BREAST CANCER

ROLE OF INFRALIMBIC EPHB2 IN FEAR EXTINCTION

FARM TO SCHOOL GRANT PROGRAM

THE ROLE OF SEMINAL AMYLOID FIBRILS IN HIV-1 TRANSMISSION ON CERVICAL MUCOSA

MODULATION OF INTESTINAL INFLAMMATION IN COLITIS BY MANIPULATING DENDRITIC CELLS

VISTA STATE

MODULATION OF INTRINSIC EXCITABILITY IN MPFC NEURONS

TARGETING SP-NK1R-EGFR INTERACTIONS IN COLITIS ASSOCIATED DYSPLASIA

THE SOUTHERN APPALACHIAN LABOR SCHOOL'S MISSION IS TO PROVIDE EDUCATION, RESEARCH, AND LINKAGES FOR WORKING CLASS AND DISENFRANCHISED PEOPLE IN ORDER TO PROMOTE UNDERSTANDING, EMPOWERMENT, AND CHANGE. SALS IS COMMITTED TO DEVELOPING A REAL COMPREHENSION OF THE SOCIAL, ECONOMIC AND LEGAL STRUCTURE WHICH AFFECTS THE LIVES OF APPALACHIAN PEOPLE. THE PROPOSED VISTA CONTINUATION PROJECT ALIGNS WITH THE EDUCATION, ECONOMIC OPPORTUNITY, VETERANS AND HEALTHY FUTURES FOCUS AREAS. THE VISTA PROJECT WILL SEEK TO ADDRESS THE GOALS OF ACHIEVING/SUSTAINING FOOD IN PLACE, HOME IN PLACE, INFORMATION IN PLACE, AND VETERANS IN PLACE. THE PROGRAMS ARE EXPECTED TO BENEFIT 1000 PEOPLE. SEVEN VISTA MEMBERS WILL CONTRIBUTE TO THE GOALS OF THE PROJECT BY PERFORMING ACTIVITIES SUCH AS ASSISTING WITH THE CONTINUATION OF A GARDENING PROGRAM, EXPANDING THE CONTINUATION OF THE HOUSING WORKCAMP VOLUNTEER PROGRAM, RESEARCHING HOUSING FOR HOMELESS AND DISABLED VETERANS, AND COORDINATING SOCIO-MEDIA SERVICES OVER THE COURSE OF ANOTHER YEAR. TO ACCOMPLISH THESE ACTIVITIES, THE VISTA MEMBERS WILL HAVE TO HAVE -- OR BE TRAINED BY US -- SKILLS IN GRANT WRITING, MARKETING, RESEARCH, COMPUTER SKILLS, AND PUBLIC SPEAKING.

FARM TO SCHOOL GRANT PROGRAM

THE ROLE OF THE HISTONE EPIGENOME IN THE PATHOPHYSIOLOGY OF ENDOMETRIOSIS

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

HOUSING COUNSELING ASSISTANCE PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

INFLUENCE OF FEAR CONDITIONING PRIOR TO COCAINE SELF-ADMINISTRATION ON COCAINE SEEKING IN ADULT RATS: ASSESSING THE ROLE OF THE FRONTOSTRIATAL CIRCUITS IN TRAUMA AND COCAINE USE CO-OCCURRENCE - PROJECT SUMMARY RESEARCH HAS SHOWN A HIGH PREVALENCE OF TRAUMA-RELATED DISORDERS AND SUBSTANCE USE DISORDER (SUD) CO- OCCURRENCE. HOWEVER, THE MECHANISMS BY WHICH A TRAUMATIC EVENT INCREASES THE VULNERABILITY TO SUD DEVELOPMENT AND RELAPSE ARE UNKNOWN. IT IS KNOWN THAT THE PRELIMBIC CORTEX (PL) AND NUCLEUS ACCUMBENS (NAC) CORE PLAY CRITICAL ROLES IN TRAUMA-RELATED DISORDERS AND SUD, BUT THE NEUROPHYSIOLOGICAL CHANGES CAUSED IN THESE STRUCTURES BY TRAUMA AND COCAINE EXPOSURE ARE NOT FULLY UNDERSTOOD. THIS PROPOSAL AIMS TO DISSECT THE MECHANISM BY WHICH A TRAUMATIC EXPERIENCE AND COCAINE EXPOSURE ALTER PL AND NAC CORE COMMUNICATION IN WAYS THAT MAY INCREASE VULNERABILITY TO COCAINE USE DISORDER DEVELOPMENT. THE HYPOTHESIS IS THAT A TRAUMATIC EVENT AND COCAINE EXPOSURE WILL CAUSE NEUROPHYSIOLOGICAL CHANGES IN PL-NAC CORE SYNAPSES, RESULTING IN INCREASED DRUG-SEEKING BEHAVIOR. TO TEST THE HYPOTHESIS, WE WILL ASSESS THE EFFECTS OF FEAR CONDITIONING (FC) AS A TRAUMATIC EVENT, AND COCAINE EXPOSURE ON COCAINE-SEEKING BEHAVIOR IN MALE AND FEMALE RATS. ALSO, WE WILL ANALYZE THE SYNAPTIC CHANGES OF THE PL-PROJECTING NEURONS TO THE NAC CORE, USING WHOLE CELL PATCH-CLAMP ELECTROPHYSIOLOGICAL RECORDINGS WITH OPTOGENETIC MANIPULATION (AIM 1), AS WELL AS THE INFLUENCE OF PL INACTIVATION ON COCAINE SEEKING (AIM 2) FROM COCAINE-EXPOSED RATS WITH OR WITHOUT FC. PRELIMINARY BEHAVIORAL DATA SHOW THAT FC PRIOR TO COCAINE EXPOSURE INCREASES CUE-PRIMED REINSTATEMENT AND COCAINE-PRIMED REINSTATEMENT IN MALE RATS, PROVIDING A SUITABLE BEHAVIORAL PARADIGM FOR INVESTIGATING THE NEUROPHYSIOLOGICAL CHANGES THAT OCCUR IN THIS COMORBIDITY. THE FINDINGS OF THE PROPOSED STUDY WILL PROVIDE INSIGHT INTO HOW PL MODULATES THE NAC CORE NEURONS IN THE PRESENCE OF A TRAUMATIC EXPERIENCE AND DRUG EXPOSURE, TO INFLUENCE DRUG-SEEKING BEHAVIOR.

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

HOUSING COUNSELING ASSISTANCE PROGRAM

APPLICATION FOR SMALL RURAL SCHOOL ACHIEVEMENT PROGRAM

SRSA APPLICATION

SRSA APPLICATION

RURAL HOUSING PRESERVATION GRANTS

RURAL HOUSING PRESERVATION GRANTS

POWER INITIATIVE FY2015

APPLICATION FOR SMALL RURAL SCHOOL ACHIEVEMENT PROGRAM

COMPREHENSIVE HSG

FARMS AND FARMERS ARE THE FOUNDATION OF THE APPALACHIAN AGRICULTURAL AND FOOD ECONOMY BUT AN AGING FARMER POPULATION, LOSSES IN BOTH FARM NUMBERS AND FARMLAND ACREAGE, AND SHIFTING CLIMATE PATTERNS THREATEN A WAY OF LIFE AND SOURCE OF REVENUE IN THE SEVEN WESTERN NORTH CAROLINA COUNTIES TARGETED BY THIS PROJECT. THROUGH ITS INCUBATOR FARM PROGRAM (PSIF), THE PATTERSON SCHOOL FOUNDATION (PSF), LOCATED IN CALDWELL COUNTY, NC, WILL ADDRESS THESE CHALLENGES BY PROVIDING THE 1,689 NEW OR BEGINNING FARMERS AND RANCHERS IN THESE COUNTIES WITH OPPORTUNITIES TO ACQUIRE THE KNOWLEDGE AND SKILLS NEEDED TO SUCCESSFULLY AND SUSTAINABLY MANAGE THEIR AGRICULTURAL OPERATIONS. THE PATTERSON SCHOOL OPERATED FROM 1909-1994, EDUCATING MOUNTAIN YOUTH ON AGRICULTURE AND INDUSTRY. THIS PROJECT WILL ADVANCE THE EFFORTS OF PSF TO RESTORE THE PATTERSON SCHOOL AS A CENTER OF AGRICULTURAL EDUCATION TO MEET THE CHALLENGES OF THE 21ST CENTURY.DURING THE ONE-YEAR PERFORMANCE PERIOD FOR THE SIMPLIFIED STANDARD GRANT, PSIF WILL HOST A SERIES OF WORKSHOPS ON TOPICS INCLUDING CLIMATE SMART, SUSTAINABLE AGRICULTURE, SOIL REGENERATION, ENVIRONMENTAL STEWARDSHIP, AGROFORESTRY, AND THE USE OF ALTERNATIVE ENERGY AND HEATING SOURCES. THESE SUSTAINABLE PRACTICES CAN ENHANCE THE FISCAL, ENVIRONMENTAL AND COMMUNAL SUCCESS OF BEGINNING FARMERS AND RANCHERS. PROJECT ACTIVITIES WILL FOSTERNETWORKING TO BUILD COMMUNITY AMONG NEW OR BEGINNING PRODUCERS AND CONNECT THEM WITH REGIONAL RESOURCES.

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

RURAL HOUSING PRESERVATION GRANTS

RURAL HOUSING PRESERVATION GRANTS

RURAL HOUSING PRESERVATION GRANTS

PURPOSE: TO SUPPORT TEACHING ARTIST FEES FOR A FREE MUSIC EDUCATION PROGRAM FOR STUDENTS.

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

THE ROLE OF FKBP5 IN ANXIETY LIKE BEHAVIORS

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

HSNG COUNSEL ASSIST GRANTS

THE COALFIELD ENVIRONMENTAL HEALTH PROJECT WILL EDUCATE RESIDENTS OF THE LOOP CREEK AND LAUREL CREEK AREA ON THE HEALTH IMPACTS OF LARGE SCALE SURFAC

PURPOSE: TO SUPPORT A FREE MUSIC EDUCATION PROGRAM FOR STUDENTS.

TO SUPPORT PROJECT GRIT (GROWTH RESILIENCE INSTINCT TENACITY) A FREE AFTER-SCHOOL MUSIC EDUCATION PROGRAM FOR STUDENTS.

TO SUPPORT PROJECT GRIT A FREE MUSIC EDUCATION PROGRAM FOR STUDENTS.

PERSISTENT POVERTY CF GRANT

PLASTICITY OF THALAMIC INPUTS OF INHIBITORY NEURONS

RURAL HOUSING PRESERVATION GRANTS

15.904 HISTORIC PRESERVATION FUND GRANTS-IN-AID AACR HISTORY SAM.GOV HISTORIC PRESERVATION FUND GRANTS-IN-AID ASSIST IN THE IDENTIFICATION, EVALUATION, AND PROTECTION OF HISTORIC PROPERTIES BY SUCH MEANS AS EDUCATION, SURVEY, PLANNING, TECHNICAL ASSISTANCE, PRESERVATION, DOCUMENTATION, AND FINANCIAL INCENTIVES LIKE GRANTS AND TAX CREDITS AVAILABLE FOR HISTORIC PROPERTIES. OPPORTUNITY P23AS00471 AFRICAN AMERICAN CIVIL RIGHTS (AACR) IS A COMPETITIVE HISTORY-BASED GRANT PROGRAM TO DOCUMENT, INTERPRET, AND PRESERVE THE SITES AND STORIES OF THE FULL HISTORY OF THE AFRICAN AMERICAN STRUGGLE TO GAIN EQUAL RIGHTS AS CITIZENS FROM THE TRANSATLANTIC SLAVE TRADE FORWARD. THIS GRANT FUNDS A BROAD RANGE OF HISTORY PROJECTS INCLUDING SURVEY AND PLANNING, RESEARCH AND DOCUMENTATION, INTERPRETATION AND EDUCATION, AND COLLECTIONS CONSERVATION. BENEFICIARIES INCLUDE STATES, TRIBES, LOCAL GOVERNMENTS, AND NONPROFITS. THIS PROJECT IS AWARDED TO THE WOODVILLE ROSENWALD SCHOOL FOUNDATION TO COLLECT ORAL HISTORIES ON THE HISTORIC WOODVILLE ROSENWALD SCHOOL AND OTHER AFRICAN AMERICAN SCHOOLS IN THE GLOUCESTER COUNTY, VA AREA.

HOUSING COUNSELING TRAINING PROGRAM

HOUSING COUNSELING ASSISTANCE PROGRAM

RURAL HOUSING PRESERVATION GRANTS

HOUSING COUNSELING ASSISTANCE PROGRAM

RURAL HOUSING PRESERVATION GRANTS

MINORITY PREDOCTORAL FELLOWSHIP PROGRAM

HOUSING COUNSELING ASSISTANCE PROGRAM

PURPOSE: THE PURPOSE OF HUD’S COMPREHENSIVE HOUSING COUNSELING (CHC) GRANT IS TO PROVIDE DIRECT FUNDING SUPPORT TO HUD’S NATION-WIDE NETWORK OF APPROVED HOUSING COUNSELING AGENCIES. FOR MORE INFORMATION ABOUT THE COMPREHENSIVE HOUSING COUNSELING GRANT PROGRAM, SEE HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/HOUSING/SFH/HCC.; ACTIVITIES TO BE PERFORMED: HOUSING COUNSELING ACTIVITIES INCLUDE PROVIDING INFORMATION, ADVICE, AND TOOLS FOR CONSUMERS SEEKING, FINANCING, MAINTAINING, RENTING, OR OWNING A HOME. AGENCIES ALSO ASSIST THOSE FACING HOMELESSNESS AND HOMEOWNERS IN NEED OF FORECLOSURE ASSISTANCE. THE HOUSING COUNSELING ACTIVITY TYPES THAT CAN BE REIMBURSED BY THE CHC GRANT INCLUDE ALL APPROVED HOUSING COUNSELING, EDUCATION, AND OUTREACH TOPICS LISTED IN THE CURRENT. HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/ADMINISTRATION/HUDCLIPS/HANDBOOKS/HSGH/7610.1. THIS INCLUDES, BUT IS NOT LIMITED TO, PRE-PURCHASE/HOME BUYING COUNSELING, RESOLVING, OR PREVENTING FORWARD OR REVERSE MORTGAGE DELINQUENCY OR DEFAULT COUNSELING, AND NON-DELINQUENCY POST-PURCHASE COUNSELING. GRANTEES ARE REQUIRED TO DEMONSTRATE, THROUGH THE CURRENT FORM HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/ADMINISTRATION/HUDCLIPS/FORMS/HUD9, HOUSING COUNSELING AGENCY ACTIVITY REPORT, THE NUMBER OF HOUSEHOLDS THAT WERE COUNSELED BY ACTIVITY TYPE AND NUMBER OF HOUSEHOLDS THAT ATTENDED WORKSHOPS BY ACTIVITY TYPE DURING THE APPLICABLE FISCAL YEAR. HOUSING COUNSELING AGENCIES MAY ALSO BE SPECIFICALLY AWARDED TO PARTNER WITH A MINORITY-SERVING INSTITUTION (MSI) TO PROVIDE HOUSING COUNSELING TO THE MSI INSTITUTIONS’ COMMUNITIES AND EXPAND THESE INSTITUTIONS’ PARTNERSHIPS WITH HOUSING COUNSELING AGENCIES. OUTPUTS AND DELIVERABLES FOR THIS GRANT AWARD IS THE SAME AS THE PARAGRAPH DESCRIBED ABOVE, HOWEVER, GRANTEES ARE REQUIRED TO PARTNER WITH A MSI TO PROVIDE THOSE ACTIVITIES. ; EXPECTED OUTCOMES: THE QUANTIFIABLE OUTCOMES FOR THE CHC GRANT INCLUDE, BUT ARE NOT LIMITED TO, THE NUMBER OF HOUSEHOLDS THAT GAINED ACCESS TO HOUSING RESOURCES; RECEIVED INFORMATION ON FAIR HOUSING, FAIR LENDING, AND/OR ACCESSIBILITY RIGHTS; IMPROVED CURRENT LIVING CONDITIONS; PURCHASED HOUSING; RECEIVED A REVERSE MORTGAGE; PREVENTED OR RESOLVED A MORTGAGE DEFAULT; AND RECEIVED A LOAN MODIFICATION. ALL POSSIBLE OUTCOMES ARE LISTED IN SECTION 10 OF THE CURRENT FORM HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/ADMINISTRATION/HUDCLIPS/FORMS/HUD9, HOUSING COUNSELING AGENCY ACTIVITY REPORT.; INTENDED BENEFICIARIES: INDIVIDUALS, GROUPS OF INDIVIDUALS, AND FAMILIES WHO ARE RENTERS, TENANTS, HOMEOWNERS, AND HOME BUYERS UNDER HUD, CONVENTIONAL, AND OTHER GOVERNMENT PROGRAMS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

HOUSING COUNSELING ASSISTANCE PROGRAM

HOUSING COUNSELING

PURPOSE: THE PURPOSE OF HUD’S COMPREHENSIVE HOUSING COUNSELING (CHC) GRANT IS TO PROVIDE DIRECT FUNDING SUPPORT TO HUD’S NATION-WIDE NETWORK OF APPROVED HOUSING COUNSELING AGENCIES. FOR MORE INFORMATION ABOUT THE COMPREHENSIVE HOUSING COUNSELING GRANT PROGRAM, SEE HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/HOUSING/SFH/HCC.; ACTIVITIES TO BE PERFORMED: HOUSING COUNSELING ACTIVITIES INCLUDE PROVIDING INFORMATION, ADVICE, AND TOOLS FOR CONSUMERS SEEKING, FINANCING, MAINTAINING, RENTING, OR OWNING A HOME. AGENCIES ALSO ASSIST THOSE FACING HOMELESSNESS AND HOMEOWNERS IN NEED OF FORECLOSURE ASSISTANCE. THE HOUSING COUNSELING ACTIVITY TYPES THAT CAN BE REIMBURSED BY THE CHC GRANT INCLUDE ALL APPROVED HOUSING COUNSELING, EDUCATION, AND OUTREACH TOPICS LISTED IN THE CURRENT. HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/ADMINISTRATION/HUDCLIPS/HANDBOOKS/HSGH/7610.1. THIS INCLUDES, BUT IS NOT LIMITED TO, PRE-PURCHASE/HOME BUYING COUNSELING, RESOLVING, OR PREVENTING FORWARD OR REVERSE MORTGAGE DELINQUENCY OR DEFAULT COUNSELING, AND NON-DELINQUENCY POST-PURCHASE COUNSELING. GRANTEES ARE REQUIRED TO DEMONSTRATE, THROUGH THE CURRENT FORM HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/ADMINISTRATION/HUDCLIPS/FORMS/HUD9, HOUSING COUNSELING AGENCY ACTIVITY REPORT, THE NUMBER OF HOUSEHOLDS THAT WERE COUNSELED BY ACTIVITY TYPE AND NUMBER OF HOUSEHOLDS THAT ATTENDED WORKSHOPS BY ACTIVITY TYPE DURING THE APPLICABLE FISCAL YEAR. HOUSING COUNSELING AGENCIES MAY ALSO BE SPECIFICALLY AWARDED TO PARTNER WITH A MINORITY-SERVING INSTITUTION (MSI) TO PROVIDE HOUSING COUNSELING TO THE MSI INSTITUTIONS’ COMMUNITIES AND EXPAND THESE INSTITUTIONS’ PARTNERSHIPS WITH HOUSING COUNSELING AGENCIES. OUTPUTS AND DELIVERABLES FOR THIS GRANT AWARD IS THE SAME AS THE PARAGRAPH DESCRIBED ABOVE, HOWEVER, GRANTEES ARE REQUIRED TO PARTNER WITH A MSI TO PROVIDE THOSE ACTIVITIES. ; EXPECTED OUTCOMES: THE QUANTIFIABLE OUTCOMES FOR THE CHC GRANT INCLUDE, BUT ARE NOT LIMITED TO, THE NUMBER OF HOUSEHOLDS THAT GAINED ACCESS TO HOUSING RESOURCES; RECEIVED INFORMATION ON FAIR HOUSING, FAIR LENDING, AND/OR ACCESSIBILITY RIGHTS; IMPROVED CURRENT LIVING CONDITIONS; PURCHASED HOUSING; RECEIVED A REVERSE MORTGAGE; PREVENTED OR RESOLVED A MORTGAGE DEFAULT; AND RECEIVED A LOAN MODIFICATION. ALL POSSIBLE OUTCOMES ARE LISTED IN SECTION 10 OF THE CURRENT FORM HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/ADMINISTRATION/HUDCLIPS/FORMS/HUD9, HOUSING COUNSELING AGENCY ACTIVITY REPORT.; INTENDED BENEFICIARIES: INDIVIDUALS, GROUPS OF INDIVIDUALS, AND FAMILIES WHO ARE RENTERS, TENANTS, HOMEOWNERS, AND HOME BUYERS UNDER HUD, CONVENTIONAL, AND OTHER GOVERNMENT PROGRAMS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

HOUSING COUNSELING ASSISTANCE PROGRAM

HOUSING COUNSELING

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

VISTA RECOVERY SUPPORT GRANTS

COMMUNITY FACILITIES - ECONOMIC IMPACT INITIATIVE GRANTS

THE PROJECT WILL INCREASE DEMOCRATIC AWARENESS AND SOCIAL MEDIA LITERACY AMONG UNDERSERVED STUDENTS IN BANGKOK THROUGH ONE SEMESTER-LONG INTERACTIVE ACTIVITIES TO PREPARE THEM TO BECOME RESPONSIBLE CITIZENS THAT STRENGTHEN DEMOCRATIC INSTITUTIONS.

20181AG511 EAST MTN. HIGH SCHOOL SCHOOL FOUNDATION

HSNG COUNSEL ASSIST GRANTS

N/A

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

INFLUENCE OF INDUSTRY-INFORMED STEM PATHWAYS ON STUDENT EXPERIENCES AND OUTCOMES IN NON-SELECTIVE URBAN SCHOOL

NATIONAL DIRECT GRANTS ARE AWARDED TO ORGANIZATIONS THAT PROPOSE TO OPERATE AMERICORPS PROGRAMS IN MORE THAN ONE STATE AND APPLY DIRECTLY TO CNCS.

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RURAL SELF-HELP HOUSING TECHNICAL ASSIST

PILOT STUDY TO PREVENT TRANSITION FROM OVERWEIGHT TO OBESITY AMONG YOUNG OVERWEIGHT COLLEGE STUDENTS IN PONCE, PUERTO RICO

PILOT STUDY TO PREVENT TRANSITION FROM OVERWEIGHT TO OBESITY AMONG YOUNG OVERWEIGHT COLLEGE STUDENTS IN PONCE, PUERTO RICO