Tides Inc

CIVIL SOCIETY INNOVATION INITIATIVE FISCAL AGENT

EXPLORING THE PARAMETER SPACE OF HIGH FREQUENCY MAGNETIC PERTURBATION IN MANIPULATING NEURAL EXCITABILITY AND PLASTICITY. - PROJECT SUMMARY/ABSTRACT NON-INVASIVE BRAIN STIMULATION (NIBS) HAS ATTRACTED CONSIDERABLE INTEREST IN THE COGNITIVE NEUROSCIENCE COMMUNITY, PROVIDING AN IMPORTANT BASIC RESEARCH TOOL TO STUDY BRAIN FUNCTION, WITH EMERGING CLINICAL APPLICATIONS TO ENHANCE FUNCTION IN INDIVIDUALS WITH NEUROLOGICAL DISORDERS. DESPITE THIS POTENTIAL, AN EMERGING LITERATURE HAS HIGHLIGHTED CONCERNS REGARDING THE RELIABILITY AND ROBUSTNESS OF TRANSCRANIAL ELECTRIC STIMULATION (TES), THE PRIMARY NIBS METHOD USED TO INDUCE CHANGES IN BRAIN PLASTICITY THROUGH THE APPLICATION OF SUBTHRESHOLD STIMULATION. THESE PROBLEMS ARE LIKELY RELATED TO THE FACT THAT TES SYSTEMS CAN ONLY INDUCE MODEST ELECTRICAL FIELDS (E-FIELD) AT THE CORTICAL SURFACE GIVEN THAT SAFETY/TOLERANCE ISSUES LIMIT THE INTENSITY OF TES STIMULATION THAT CAN BE DELIVERED AT THE SCALP. WE DEVELOPED A RADICALLY NEW NIBS APPROACH, ONE IN WHICH SUBTHRESHOLD MODULATION OF NEURAL EXCITABILITY IS BROUGHT ABOUT VIA OSCILLATING MAGNETIC FIELDS AT KHZ FREQUENCIES. THIS SYSTEM, REFERRED TO KTMP (KHZ TRANSCRANIAL MAGNETIC PERTURBATION) SIGNIFICANTLY INCREASES THE RANGE OF SUBTHRESHOLD E-FIELD INDUCTION, AND THROUGH MODULATION OF THE ENVELOPE OF THE KHZ CARRIER FREQUENCY, CAN IMPOSE E-FIELDS AT PHYSIOLOGICAL RELEVANT FREQUENCIES. THE THREE-YEAR FUNDING PERIOD WILL BE USED TO CONDUCT TESTING WITH HUMAN PARTICIPANTS TO ASSESS THE TOLERABILITY AND EFFICACY OF THE SYSTEM IN PRODUCING CHANGES IN CORTICAL PHYSIOLOGY AND BEHAVIOR. IF OUR EXPECTATIONS ARE CONFIRMED, THIS SYSTEM WILL INTRODUCE A POWERFUL NEW METHOD FOR MODULATING NEURAL EXCITABILITY AND AS SUCH, PROVIDE CLINICIANS WITH A PROMISING NEW INTERVENTION IN THE TREATMENT OF NEUROLOGICAL DISORDERS.

A PEPTIDE-BASED POINT-OF-CARE VERTICAL FLOW ASSAY FOR THE RAPID DIAGNOSIS OF LYME DISEASE

DEVELOPMENT OF A NOVEL CHEMOKINE RECEPTOR ANTAGONIST PEPTIDE AS A NON-OPIOID TREATMENT FOR RELIEF OF CHRONIC PAIN - 7. PROJECT SUMMARY IN RESPONSE TO RFS-NS-20-11, CREATIVE BIO-PEPTIDES, INC. WILL DEVELOP THE MULTI-CHEMOKINE RECEPTOR ANTAGONIST PEPTIDE R103 TO PROVIDE A NON-OPIOID, POTENTIALLY DISEASE MODIFYING TREATMENT FOR NEUROPATHIC PAIN CONDITIONS. WE HAVE COMPLETED PROOF-OF-CONCEPT (POC) ANIMAL STUDIES IN NEUROPATHIC PAIN BY PARTIAL NERVE LIGATION AND DIABETES. WE WILL CONDUCT A FURTHER POC STUDY OF R103 BENEFIT IN CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY (CIPN), A DOSE-LIMITING SIDE EFFECT OF MANY ANTICANCER DRUGS THAT CAN AFFECT 68% OR MORE OF CANCER PATIENTS. WE WILL ALSO ESTABLISH A NEUROPROTECTIVE MECHANISM FOR R103 PAIN EFFECTS. ADDITIONAL CHRONIC PAIN PATIENTS THAT MAY BENEFIT FROM R103 INCLUDE THOSE WITH SPINAL CORD INJURY, CHRONIC LOW-BACK PAIN, AND POST-HERPETIC NEURALGIA. OUR INITIAL TARGET PATIENT POPULATION ARE THE 2.5 MILLION AMERICANS WITH DIABETIC PERIPHERAL NEUROPATHY (DPN), THE MOST COMMON CHRONIC NEUROPATHIC PAIN CONDITION. CHEMOKINES, MOLECULES OF THE INNATE IMMUNE SYSTEM THAT MEDIATE INFLAMMATION, ACTING THROUGH RECEPTORS SUCH AS CCR2, CCR5, AND CCR8 PROMOTE PAIN BY MULTIPLE MECHANISMS THAT CAUSE SUSTAINED EXCITABILITY OF PRIMARY NOCICEPTIVE NEURONS, DESENSITIZE ENDOGENOUS OPIOID ANTI-PAIN EFFECTS, ACTIVATE MICROGLIA AND ASTROCYTES, AND CAUSE PERIPHERAL MONOCYTE INFILTRATION INTO CNS. BLOCKING MULTIPLE CHEMOKINE RECEPTORS THAT ESTABLISH AND SUSTAIN CHRONIC PAIN WITH THE MULTI-CHEMOKINE RECEPTOR ANTAGONIST (CRA) R103 IS A NEW AND LARGELY UNTESTED NON-OPIOID APPROACH TO PAIN TREATMENT. SUBSTANTIAL INDEPENDENT RESEARCH BY OTHERS SHOWS THE VALUE OF CRA’S IN DIVERSE CHRONIC PAIN CONDITIONS. R103 IS A PREFERRED CRA BECAUSE OF ITS EASE OF DOSING, RAPID ENTRY INTO THE CNS, LACK OF TOXICITY AND SIDE EFFECTS, AND POTENTIAL TO TREAT THE DEFINING PATHOLOGY OF NEUROPATHIC PAIN, AXONAL DEGENERATION. UNLIKE CURRENT FDA APPROVED CHEMOKINE ANTAGONISTS (PLERIXAFOR®, SELZENTRY®) WHICH HAVE SIGNIFICANT SAFETY CONCERNS (ALLERGIC RISKS, NEED TO BE INJECTED, “BLACK-BOX” WARNING FOR HEPATOTOXICITY), R103 IS SAFE AND TARGETS MULTIPLE CHEMOKINE RECEPTORS (CCR2/CCR5/CCR8) IMPLICATED IN PERSISTENT PAIN STATES. THE PROGRAM WE PROPOSE WILL RESULT IN AN IND FOR DPN AND CINP USE AND FAST-TRACK HUMAN PHASE 1 STUDIES WITH EXPLORATORY PATIENT EFFICACY COHORTS. WE WILL ASSESS ANY RESPIRATORY DEPRESSION WITH R103, AN FDA MANDATE FOR PAIN DRUGS. WE WILL CONDUCT SCALE-UP PEPTIDE MANUFACTURE AND COMPLETE IND-ENABLING PRE-CLINICAL SAFETY AND PK/PD STUDIES. WE WILL SCHEDULE A PRE-IND MEETING WITH THE FDA TO ESTABLISH A REGULATORY APPROVAL PLAN AND SECURE AN IND FOR FIRST-IN HUMAN STUDIES. THE STUDIES IN THE PROPOSAL SUPPORT EXPANDING THE IND TO TREAT OTHER NEUROPATHIES, LIKE CIPN, AND EVENTUALLY NEURALGIAS, AND BACK PAIN.

A SYNAPSE-PROTECTING SMALL PEPTIDE TO TREAT A-SYN/TAU MIXED PROTEINOPATHIES IN ALZHEIMER'S DISEASE RELATED DEMENTIAS (ADRD) - 7. PROJECT SUMMARY THERE IS STRONG EVIDENCE OF CO-MORBID PATHOLOGIES (Α-SYNUCLEIN, AMYLOID Β, TAU) IN AGE-RELATED DEMENTIAS THAT CAUSE SYNERGISTIC CONTRIBUTIONS TO NEURODEGENERATION SUCH THAT PATIENTS EXHIBIT A MORE SEVERE AND RAPID DISEASE PROGRESSION. SIMULTANEOUS TREATMENT OF MULTIPLE PROTEINOPATHIES COMMONLY OCCURRING IN THESE PATIENTS (A LARGELY IGNORED STRATEGY) WILL BE REQUIRED TO EFFECTIVELY TREAT ADRDS SUCH AS LBDS, WHICH ACCOUNT FOR UP TO 25% OF ALL DEMENTIAS IN PATIENTS OLDER THAN 65 YEARS. THERE ARE CURRENTLY NO DISEASE-MODIFYING TREATMENTS FOR THESE PATIENTS. SYNAPSE LOSS IS THE PRINCIPAL CAUSE OF MEMORY AND COGNITIVE DECLINE IN VARIOUS DEMENTIAS AND OCCURS SIGNIFICANTLY PRIOR TO NEURONAL LOSS. OUR SCIENTIFIC PREMISE IS THAT EFFECTIVE TREATMENTS FOR LBD NEEDS TO MITIGATE SYNAPSE LOSS CAUSED BY Α-SYN, AΒ, AND TAU ACTIVATION OF A WELL-KNOWN PRPC/NOX DEPENDENT MECHANISM INVOLVING ACTIN/COFILIN-ROD FORMATION THAT LEADS TO DISRUPTION OF CYTOARCHITECTURE FOLLOWED BY RAPID LOSS OF DENDRITIC SPINES AND SYNAPSES. CHEMOKINE RECEPTORS OF THE INNATE IMMUNE SYSTEM ARE ALSO PRESENT ON NEURONS AND IN OUR RECENT R43 WE SHOWED THAT TWO OF THEIR ANTAGONISTS (BOTH APPROVED DRUGS) EXERT A NEGATIVE ALLOSTERIC EFFECT, LIKELY VIA PHYSICAL INTERACTION IN MEMBRANE RAFTS, TO SUPPRESS PRPC/NOX ACTIVATION AND SUBSEQUENT SYNAPSE LOSS. THIS NOVEL FINDING STRONGLY SUGGESTS CHEMOKINE RECEPTOR ANTAGONISTS AS POTENTIAL TREATMENTS FOR MIXED- PROTEINOPATHY DEMENTIAS. OUR R43 RESULTS SHOW THAT RAP-103, A CCR2/CCR5 ANTAGONIST, PREVENTS AND REVERSES BOTH Α-SYN AND AΒ RODENT AND HUMAN SYNAPSE LOSS IN VIVO AT PM DOSES AND PREVENTS COGNITIVE DEFICITS IN AN Α- SYN TRANSGENIC ANIMAL MODEL. IN ORDER TO BROADEN THE TREATMENT TARGETS TO INCLUDE TAU EFFECTS WE WILL CONDUCT A DEFINITIVE STUDY OF RAP-103 EFFECTS ON LBD MIXED-PROTEINOPATHY RELEVANT BIOMARKERS, DISEASE MARKERS, SYNAPTIC DAMAGE MARKERS AND CORRELATE THOSE WITH COGNITIVE PERFORMANCE AND RESTORATION OF FUNCTIONAL SYNAPSES IN TG4510 TAU/Α-SYN MICE. AT 6 MONTHS, WHEN ANIMALS SHOW COGNITIVE IMPAIRMENTS, WE WILL ADMINISTER RAP-103 BY ORAL DOSING FOR 8 WEEKS, THEN DETERMINE PERFORMANCE IN THE MORRIS WATER MAZE TEST OF SPATIAL MEMORY AND LEARNING. WE WILL COLLECT THE BRAINS TO DETERMINE THE EFFECT OF RAP-103 ON OLIGOMERIC TAU, PTHR231 TAU, MULTIMERIC TOTAL Α-SYN AND PSER129 ΑSYN, INFLAMMATION IN MICROGLIA AND ASTROCYTES, CYTOKINE AND CHEMOKINE EXPRESSION, AND SYNAPTO-DENDRITIC LOSS IN IN CORTEX AND HIPPOCAMPUS. IMMUNOREACTIVE AREA, DENSITY, MEAN SIGNAL, MEAN SIZE AND INTEGRATED OPTICAL DENSITY (IOD) OF ALL OBJECTS WITH ALL MARKERS WILL BE BLINDLY QUANTIFIED BY OBJECTIVE MEASURES. WE WILL DETERMINE THE EFFECT OF RAP-103 ON FUNCTIONAL SYNAPSES DETERMINED FROM ELECTROPHYSIOLOGICAL MEASUREMENTS IN CA3 TO CA1 REGION OF HIPPOCAMPUS (EX VIVO BRAIN SLICE) FROM TG4510. THE STUDIES WILL PROVIDE GO-NO GO QUANTIFIABLE INFLECTION POINTS TO DECIDE FURTHER DEVELOPMENT. WE HAVE COMPLETED INITIAL ANIMAL SAFETY STUDIES AND HAVE RECEIVED A PRE-IND MEETING DATE WITH THE FDA TO GET COMMENTS ON OUR FIRST-IN-HUMAN CLINICAL PLAN IN HEALTHY NORMAL VOLUNTEERS. SUCCESSFUL COMPLETION OF THE AIMS WILL SUPPORT AN IND FOR A PROOF-OF-CONCEPT PHASE 2 STUDY IN AN ADRD INDICATION.

DEVELOPMENT OF A NOVEL CHEMOKINE RECEPTOR ANTAGONIST AS A TREATMENT FOR OPIOID USE DISORDER - 7. PROJECT SUMMARY OVER 2.1 MILLION AMERICANS SUFFER FROM OPIOID USE DISORDER (OUD) RESULTING IN 47,000 DEATHS ANNUALLY. INDIVIDUALS SEEKING TREATMENT MUST DEAL WITH LIMITED ACCESS TO QUALIFIED HEALTHCARE PROFESSIONALS, AS WELL AS BARRIERS TO GETTING MEDICATION ASSISTED TREATMENT (MAT). COMMON MAT TREATMENTS UTILIZING BUPRENORPHINE OFTEN REQUIRE PATIENTS TO EXPERIENCE WITHDRAWAL SYMPTOMS FOR SEVERAL DAYS PRIOR TO MAT INITIATION. FURTHER, THE STIGMA OF OUD TREATMENT, WHICH COULD BE REDUCED IF PATIENTS RECEIVED AMBULATORY CARE, ACTS AS AN ADDITIONAL HINDRANCE TO ACCESS AND TREATMENT. THERE IS A PAUCITY OF OPTIONS AVAILABLE FOR THESE INDIVIDUALS AND THE MEDICAL STAFF WHO TREAT THEM, AS METHADONE, BUPRENORPHINE AND NALOXONE, THE STANDARDS OF CARE, ARE OFTEN NOT SUCCESSFUL IN ACHIEVING TREATMENT GOALS. EMERGING EVIDENCE DEMONSTRATES THAT BRAIN CHEMOKINE RECEPTORS CONTROL DOPAMINE REWARD PATHWAYS AND INFLUENCE BEHAVIORAL EFFECTS OF DRUG ABUSE WHICH CAN BE BLUNTED BY CHEMOKINE RECEPTOR ANTAGONISTS. CBP PROPOSES TO EXPAND MAT CAPABILITIES FOR OUD WITH RAP-103, A SMALL ORALLY STABLE CHEMOKINE RECEPTOR ANTAGONIST PEPTIDE THAT BLOCK’S OPIOID ACQUISITION, MAINTENANCE, AND WITHDRAWAL. OUR EVIDENCE INDICATES THAT RAP-103 HAS SIGNIFICANT SAFETY AND EFFICACY ADVANTAGES AS A NON-OPIOID FOR MAT USE THAT BLOCKS OPIOID SELF- ADMINISTRATION IN FIXED-RATIO TESTS THAT SHOW REDUCTION IN TOTAL OPIOID CONSUMED AND IN PROGRESSIVE-RATIO EXPERIMENTS THAT SHOW GREATLY REDUCED MOTIVATION TO MAINTAIN OPIOID USE. ADDITIONALLY RAP-103 MITIGATES SIGNS OF NALOXONE INDUCED OPIOID WITHDRAWAL IN A RODENT MODEL OF MORPHINE DEPENDENCE. IN THIS PROJECT, OUR OBJECTIVE IS TO FURTHER DEMONSTRATE THE FEASIBILITY OF RAP-103 AS A MAT AGENT AND TO PROGRESS TO HUMAN TESTING. WE INTEND TO DO THIS BY OPTIMIZING THE LOWEST DOSE AT WHICH RAP-103 MITIGATES OPIOID SELF-ADMINISTRATION IN PROGRESSIVE- RATIO EXPERIMENTS IN MALE AND FEMALE RATS. IN VIEW OF THE UNIQUE MECHANISM OF RAP-103 ACTION VIA CHEMOKINE RECEPTOR ANTAGONISM WE WILL IDENTIFY CHEMOKINE AND CYTOKINE CHANGES IN MESOLIMBIC (VTA AND NUCLEUS ACCUMBENS) BRAIN REWARD AREAS TO PROVIDE A MECHANISM FOR HOW RAP-103 MAY MITIGATE THE REWARDING EFFECTS OF OPIOIDS AND OTHER DRUGS OF ABUSE. CBP HAS BEEN CONDUCTING PRE-CLINICAL PHARMACOKINETIC AND TOXICOKINETIC SAFETY TESTING TOWARD FULFILLING REQUIREMENTS FOR FILING AN IND AND CONDUCTING FIRST-IN-HUMAN SAFETY TESTING. CBP HAS ASSEMBLED A TEAM OF EXPERIENCED MAT CLINICIAN/RESEARCHERS TO PLAN A CLINICAL DEVELOPMENT PROGRAM FOR AN OUD USE. WE PROPOSE TO CONDUCT THE ADDITIONAL PRE-CLINICAL SAFETY TESTS THAT WOULD SUPPORT FILING OF AN IND FOR AN OUD TREATMENT USE OF RAP-103 AT THE END OF THE PROGRAM. CBP WILL ADVANCE CLINICAL DEVELOPMENT OF RAP-103 AS A MAT FOR OUD WITH GOALS TO PROVIDE SAFER TREATMENT WITH NO ABUSE RISK, IMPROVE PATIENT ACCESS, ADHERENCE, TOLERANCE AND TREATMENT. THE SUPERIOR SAFETY PROFILE (NO RESPIRATORY DEPRESSION AND ABUSE OR DIVERSION POTENTIAL), REDUCED MOTIVATION TO MAINTAIN OPIOID USE, MITIGATION OF WITHDRAWAL SYMPTOMS AND ORAL BIOAVAILABILITY BY ONCE DAILY DOSING WOULD MAKE RAP-103 A HIGHLY VALUABLE ADDITION TO THE OUD MAT TOOLBOX, INITIALLY AS AN ADJUNCTIVE THERAPY THAT CAN HELP OVERCOME THE UNDERUTILIZATION OF MAT ACCESS AND USE.

TILLAMOOK COUNTY COALITION TO END DOMESTIC VIOLENCE OUTREACH, EDUCATION AND PREVENTION PROJECT.

MULTI-ANTIGEN PEPTIDE ASSAY FOR THE SERODIAGNOSIS OF LYME DISEASE

A POINT OF CARE VERTICAL FLOW ASSAY FOR THE DIRECT DETECTION OF BABESIA MICROTI AND THE SERODIAGNOSIS OF LYME DISEASE. - BABESIA MICROTI IS A PARASITE THAT IS TRANSMITTED BY THE SAME SPECIES OF TICKS THAT TRANSMIT LYME DISEASE. IT IS THE CAUSATIVE AGENT OF BABESIOSIS, A DISEASE WITH A WIDE ARRAY OF CLINICAL PRESENTATIONS THAT CAN RANGE FROM AN ASYMPTOMATIC CARRIER STATE IN SOME OTHERWISE HEALTHY INDIVIDUALS TO CAUSING FATAL INFECTION IN OTHERS. MOST CASES OF SEVERE DISEASE THAT RESULT IN HOSPITALIZATION OCCUR IN INDIVIDUALS WITH UNDERLYING HEALTH ISSUES SUCH AS IMMUNE SUPPRESSION AND LACK OF A SPLEEN. HOWEVER, INDIVIDUALS OF GREATER THAN 50 YEARS OF AGE ARE ALSO AT RISK FACTOR FOR SEVERE INFECTION, AND SEVERE INFECTIONS HAVE BEEN SEEN IN YOUNGER INDIVIDUALS AS THE DISEASE BECOMES MORE PREVALENT. IT IS CLEAR THAT NOT ALL OF THE FACTORS THAT PREDISPOSE SOMEONE TO SEVERE INFECTION ARE KNOWN. AS WITH ALL TICK TRANSMITTED DISEASES, THE INCIDENCE AND GEOGRAPHICAL DISTRIBUTION OF BABESIOSIS HAS BEEN INCREASING STEADILY OVER THE PAST 20 YEARS. B. MICROTI CAN ALSO BE SPREAD FROM MOTHER TO CHILD DURING BIRTH, AND TO TRANSFUSION RECIPIENTS THROUGH TRANSFUSION WITH INFECTED BLOOD. IT IS ONE OF THE MOST COMMON CAUSES OF TRANSFUSION TRANSMITTED INFECTIONS REPORTED TO THE FDA IN THE US. IT IS ALSO A COMMON CO-INFECTION WITH LYME DISEASE, AND THE IMPACT OF COINFECTION ON THE COURSE OF BABESIOSIS AND LYME DISEASE IS CURRENTLY UNKNOWN. UNLIKE ANAPLASMOSIS, ANOTHER COMMON COINFECTION WITH LYME DISEASE, THE THERAPIES USED TO TREAT LYME DISEASE WILL NOT IMPACT BABESIOSIS, AND VICE VERSA. ACCURATE DIAGNOSIS IS NECESSARY FOR APPROPRIATE THERAPY TO BE APPLIED FOR EACH INFECTION. AS WITH MOST INFECTIOUS DISEASES, EARLY TREATMENT CAN PREVENT THE PROGRESSION TO SEVERE DISEASE. THERE ARE CURRENTLY NO RAPID DIAGNOSTIC ASSAYS AVAILABLE FOR BABESIOSIS. AS IT IS TRANSMITTED BY THE SAME TICKS AS LYME DISEASE, AND IS A COMMON COINFECTION, WE PROPOSE THE DEVELOPMENT OF A POINT OF CARE ASSAY CAPABLE OF SUPPORTING THE DIAGNOSIS OF BOTH LYME DISEASE AND BABESIOSIS. WE HAVE PREVIOUSLY DEVELOPED A POINT OF CARE, MULTIPLEX, VERTICAL FLOW SERODIAGNOSTIC ASSAY FOR LYME DISEASE THAT HAS THE SAME SENSITIVITY AND SPECIFICITY OF THE CURRENTLY USED CENTRAL LAB TWO-TIER TESTING PARADIGM, BUT CAN BE PERFORMED IN 15 MINUTES AT THE SITE OF PATIENT CARE. IN THE CURRENT PROPOSAL, WE WILL ADD AN ANTIGEN CAPTURE ASSAY TO THIS PLATFORM TO DIRECTLY DETECT B. MICROTI SIMULTANEOUSLY WITH SERODIAGNOSIS OF LYME DISEASE AT THE POINT OF CARE. THIS ANTIGEN CAPTURE ASSAY WILL PROVIDE DIRECT PROOF OF B. MICROTI INFECTION, WHILE THE SERODIAGNOSTIC ARM WILL PROVIDE SUPPORT FOR THE CLINICAL DIAGNOSIS OF LYME DISEASE. FOR THIS WE PROPOSE TWO AIMS, 1) DERIVE HIGH AFFINITY MONOCLONAL ANTIBODIES TO SERVE AS CAPTURE-REPORTERS FOR BABESIA MICROTI SECRETED ANTIGEN 1, AND 2) DEVELOPMENT OF A COMBINED VERTICAL FLOW ASSAY FOR LYME DISEASE SEROLOGY AND BABESIA ANTIGEN DETECTION. THIS ASSAY WILL FILL A CRITICAL UNMET NEED FOR RAPID ASSAYS TO SUPPORT THE DIAGNOSIS OF TICK-TRANSMITTED DISEASES AT THE POINT-OF-CARE AND IMPROVE PATIENT OUTCOMES THROUGH EARLIER ANTIMICROBIAL INTERVENTIONS.

EFFICACY OF KTMP, A NOVEL NON-INVASIVE BRAIN STIMULATION METHOD, FOR THE TREATMENT OF ANHEDONIA PATIENTS. - PROJECT SUMMARY/ABSTRACT THE DISCOVERY OF MORE EFFECTIVE TREATMENTS FOR MAJOR DEPRESSIVE DISORDER (MDD) IS A PRESSING CLINICAL DEMAND. NON-INVASIVE BRAIN STIMULATION (NIBS) OFFERS A PROMISING TREATMENT FOR MANY NEUROLOGICAL AND PSYCHIATRIC DISORDERS. HOWEVER, TO DATE, THE CLINICAL EFFICACY HAS PROVEN HIGHLY VARIABLE. THIS IS LIKELY BECAUSE CURRENT NIBS APPROACHES CANNOT PRECISELY MODULATE PATTERNS OF BRAIN ACTIVITY AT INTENSITY LEVELS SUFFICIENT TO PRODUCE PHYSIOLOGICAL AND BEHAVIORAL CHANGE THAT IS CLINICALLY RELEVANT. THE GOAL OF THIS PROPOSAL IS TO TEST AND VALIDATE A NOVEL FIRST-IN-CLASS NON-INVASIVE APPROACH TO ENGAGE THE BRAIN REWARD CIRCUITRY FOR TREATING ANHEDONIA, A CORE SYMPTOM OF MDD. WE HAVE DEVELOPED A KILOHERTZ TRANSCRANIAL MAGNETIC PERTURBATION (KTMP) DEVICE, WHICH ALLOWS MODULATING NEURAL ACTIVITY NON-INVASIVELY – WITH NO PATIENT DISCOMFORT – AT AND BEYOND STIMULATION INTENSITIES ASSOCIATED WITH SIGNIFICANT PHYSIOLOGICAL AND BEHAVIORAL CHANGE, SOMETHING THAT IS DIFFICULT TO ACHIEVE WITH EXISTING NIBS METHODS. THE THREE-YEAR FUNDING PERIOD WILL BE USED TO ASSESS PROOF-OF-MECHANISM FOR THE EFFICACY OF KTMP IN IMPROVING ANHEDONIA IN PATIENTS SUFFERING FROM MDD. WE WILL APPLY KTMP OVER THE DORSAL PREFRONTAL CORTEX (DLPFC) TO ENGAGE DEEP STRUCTURES WITHIN THE REWARD CIRCUITRY THAT ARE CONNECTED TO THE DLPFC. SPECIFICALLY, OUR GOAL IS TO INFLUENCE THE VENTRAL STRIATUM, A KEY STRUCTURE THAT IS ASSOCIATED WITH ANHEDONIA. USING A NOVEL FMRI-BASED NEURONAVIGATION APPROACH, WE WILL PERSONALIZE THE PRECISE LOCATION WITHIN DLPFC TO OPTIMIZE THE ENGAGEMENT OF THE REWARD NETWORK. WE WILL ASSESS WHETHER KTMP LEADS TO AN INCREASE IN VENTRAL STRIATAL ACTIVATION DURING REWARD ANTICIPATION (AIM 1) AND EVALUATE IF THESE PHYSIOLOGICAL CHANGES ARE ASSOCIATED WITH REDUCED ANHEDONIA SYMPTOMS (AIM 2). IF OUR EXPECTATIONS ARE CONFIRMED, OUR NOVEL NIBS SYSTEM HOLDS THE PROMISE OF REVOLUTIONIZING THE TREATMENT LANDSCAPE FOR PATIENTS WITH DEBILITATING ANHEDONIA SYMPTOMS, PAVING THE WAY FOR A NEW ERA OF ENHANCED RECOVERY AND IMPROVED QUALITY OF LIFE.

A MULTILATERAL INITIATIVE THAT SECURES CONCRETE COMMITMENTS FROM GOVERNMENTS TO PROMOTE TRANSPARENCY, EMPOWER CITIZENS, FIGHT CORRUPTION, AND HARNES

NURSE EDUCATION, PRACTICE, QUALITY, AND RETENTION - INTERPROFESSIONAL COLLBORATIVE PRACTICE

AFFORDABLE CARE ACT: NURSE MANAGED HEALTH CLINICS

THIS AWARD FUNDS THE APPROVED 2023-2024 AMERICORPS NATIONAL DIRECT PROGRAM. NO MEMBER MAY ENROLL PRIOR TO THE APPROVED START DATE OF THE MEMBER ENROLLMENT PERIOD. YOUR 2023-2024 REGULATORY MATCH IS 24% AND YOUR BUDGETARY MATCH IS 39.0%. THIS AWARD INCLUDES ARP FUNDING INTENDED TO INCREASE THE LIVING ALLOWANCE, PROVIDE MATCH REPLACEMENT FUNDS, AND/OR EXPAND CURRENT ACTIVITIES. TO DO THIS, WE WILL AWARD $70,173.00 FOR LIVING ALLOWANCE INCREASES.

DEVELOPMENT OF A CYTOKINE RELEASE ASSAY FOR THE DIAGNOSIS OF LYME DISEASE

TILLAMOOK COUNTY CONTINUITY OF INTERVENTION PARTNERS IS TO ADDRESS CURRENT GAPS IN OUR COORDINATED COMMUNITY RESPONSE IN ORDER TO INCREASE SAFETY FOR SURVIVORS AND TO INCREASE OFFENDER ACCOUNTABILITY

TRANSITION TO SUCCESS

MEDICAL ACCESS AND CHIP REAUTHORIZATION ACT (MACRA) FUNDING OPPORTUNITY: CONNECTING KIDS TO COVERAGE: OUTREACH AND ENROLLMENT COOPERATIVE AGREEMENTS

PROJECT TITLE NOT PROVIDED

A NOVEL METHOD OF NON-INVASIVE BRAIN STIMULATION TO ENHANCE MOTOR FUNCTION IN CHRONIC STROKE PATIENTS - PROJECT SUMMARY/ABSTRACT THE DISCOVERY OF MORE EFFECTIVE TREATMENT FOR STROKE IS A PRESSING CLINICAL DEMAND. NON-INVASIVE BRAIN STIMULATION (NIBS), OFFERS A PROMISING TREATMENT FOR MANY NEUROLOGICAL AND PSYCHIATRIC DISORDERS. HOWEVER, TO DATE, THE CLINICAL EFFICACY HAS PROVEN HIGHLY VARIABLE. THIS IS LIKELY BECAUSE CURRENT NIBS APPROACHES CANNOT PRECISELY MODULATE PATTERNS OF BRAIN ACTIVITY AT INTENSITY LEVELS SUFFICIENT TO PRODUCE PHYSIOLOGICAL AND BEHAVIORAL CHANGE THAT ARE CLINICALLY RELEVANT. THE GOAL OF THIS PROPOSAL IS TO TEST AND VALIDATE A NOVEL FIRST-IN-CLASS NON-INVASIVE APPROACH TO ENHANCE MOTOR FUNCTION IN CHRONIC STROKE PATIENTS. WE HAVE DEVELOPED A KILOHERTZ TRANSCRANIAL MAGNETIC PERTURBATION (KTMP) DEVICE, WHICH ALLOWS TO TARGET FREQUENCY-SPECIFIC NEURAL ACTIVITY NON-INVASIVELY - WITH NO PATIENT DISCOMFORT - AT AND BEYOND STIMULATION INTENSITIES ASSOCIATED WITH ENHANCED RECOVERY FROM STROKE (UP TO 8 V/M), SOMETHING THAT IS NOT POSSIBLE TO ACHIEVE WITH EXISTING NIBS METHODS. THE THREE-YEAR FUNDING PERIOD WILL BE USED TO EVALUATE THE PRELIMINARY EFFICACY OF KTMP IN IMPROVING UPPER LIMB MOTOR PERFORMANCE IN PATIENTS SUFFERING FROM CHRONIC STROKE. AFTER CONFIRMING THE SAFETY AND TOLERABILITY OF KTMP IN A LARGER COHORT OF CHRONIC STROKE PATIENTS, WE WILL TARGET THE PERILESIONAL MOTOR CORTEX AND ASSESS SHORT-TERM (AIM 1) AND LONG-TERM (AIM 2) IMPROVEMENT OF MOTOR PERFORMANCE, AND CORRESPONDING PHYSIOLOGICAL CHANGES INDUCED BY KTMP STIMULATION. IF OUR EXPECTATIONS ARE CONFIRMED, OUR NOVEL NIBS SYSTEM HOLDS THE PROMISE OF REVOLUTIONIZING THE TREATMENT LANDSCAPE FOR PATIENTS WITH DEBILITATING DYSFUNCTION POST-STROKE, PAVING THE WAY FOR A NEW ERA OF ENHANCED RECOVERY AND IMPROVED QUALITY OF LIFE.

FULL SERVICE COMMUNITY SCHOOLS PROGRAM

COVERAGE FOR CALIFORNIA'S LATINO CHILDREN

THE RURAL DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING PROGRAM (RURAL PROGRAM) IS AUTHORIZED BY 34 U.S.C. 12341. RURAL PROGRAM FUNDS ARE USED TO SUPPORT PROGRAMS THAT: 1) IDENTIFY, ASSESS, AND APPROPRIATELY RESPOND TO CHILD, YOUTH, AND ADULT VICTIMS OF DOMESTIC VIOLENCE, SEXUAL ASSAULT, DATING VIOLENCE, AND STALKING IN RURAL COMMUNITIES; 2) ESTABLISH AND EXPAND VICTIM SERVICES IN RURAL COMMUNITIES TO CHILD, YOUTH, AND ADULT VICTIMS; 3) INCREASE THE SAFETY AND WELL-BEING OF WOMEN AND CHILDREN IN RURAL COMMUNITIES, BY (A) DEALING DIRECTLY AND IMMEDIATELY WITH DOMESTIC VIOLENCE, SEXUAL ASSAULT, DATING VIOLENCE, AND STALKING; AND (B) CREATING AND IMPLEMENTING STRATEGIES TO INCREASE AWARENESS AND PREVENT THESE CRIMES; AND 4) DEVELOP, EXPAND, IMPLEMENT, AND IMPROVE THE QUALITY OF SEXUAL ASSAULT FORENSIC MEDICAL EXAMINATION OR SEXUAL ASSAULT NURSE EXAMINER PROGRAMS. GRANTEES MUST USE AT LEAST ONE OF THE FOLLOWING STRATEGIES IN IMPLEMENTING THEIR PROJECTS: 1) IMPLEMENT, EXPAND, AND ESTABLISH COOPERATIVE EFFORTS AND PROJECTS AMONG LAW ENFORCEMENT OFFICERS, PROSECUTORS, VICTIM SERVICE PROVIDERS, AND OTHER RELATED PARTIES TO INVESTIGATE AND PROSECUTE INCIDENTS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING; 2) PROVIDE TREATMENT, COUNSELING, ADVOCACY, LEGAL ASSISTANCE, AND OTHER LONG-TERM AND SHORT-TERM VICTIM AND POPULATION SPECIFIC SERVICES TO ADULT AND MINOR VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING IN RURAL COMMUNITIES; 3) WORK IN COOPERATION WITH THE COMMUNITY TO DEVELOP EDUCATION AND PREVENTION STRATEGIES DIRECTED TOWARD SUCH ISSUES; 4) DEVELOP, ENLARGE, OR STRENGTHEN PROGRAMS ADDRESSING SEXUAL ASSAULT; AND 5) DEVELOP PROGRAMS AND STRATEGIES THAT FOCUS ON THE SPECIFIC NEEDS OF VICTIMS OF WHO RESIDE IN REMOTE RURAL AND GEOGRAPHICALLY ISOLATED AREAS. WITH THIS CONTINUATION RURAL DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING GRANT AWARD, TIDES OF CHANGE, IN PARTNERSHIP WITH TILLAMOOK COUNTY SHERIFFS OFFICE, TILLAMOOK COUNTY PAROLE & PROBATION, TILLAMOOK COUNTY DISTRICT ATTORNEYS OFFICE, TILLAMOOK COUNTY DISTRICT ATTORNEYS VICTIMS ASSISTANCE PROGRAM, TILLAMOOK COUNTY EMERGENCY COMMUNICATIONS DISTRICT, MANZANITA POLICE DEPARTMENT, AND TILLAMOOK CITY POLICE DEPARTMENT, WILL IMPLEMENT A VICTIM SERVICES PROJECTFOR THE COUNTY OF TILLAMOOK IN OREGON. SPECIFIC ACTIVITIES WILL INCLUDE: 1) SUPPORTING A FULL-TIMECOORDINATED COMMUNITY RESPONSE COORDINATOR/ADVOCATE AND; 2) HIRING AHALF-TIMEDV/SA DETECTIVE/INVESTIGATORWHO WILL CONDUCT FOLLOW-UP INVESTIGATIONS FOR ALL DV/SA REPORTS; 3)HIRING AFULL-TIME BILINGUAL ADVOCATEAND ONE .20 FTE BILINGUAL DIRECTOR OF SERVICES WHO WILL OFFER SPANISH-SPEAKING VICTIMS THE FULL RANGE OF ADVOCACY SERVICES PROVIDED TO ALL VICTIMS AS WELL AS CULTURALLY SPECIFIC SERVICES; 4) DEVELOPING ANDIMPLEMENTINGTHE ADVOCATE INITIATED RESPONSE (AIR) FOR DOMESTIC VIOLENCE INCIDENTS AND THE SEXUAL ASSAULT RESPONSE TEAM (SART); AND 5) PROVIDING OVERSIGHT TO THESE TWO PROGRAMS TO ENSURE THAT VICTIMS WHO ACCESS SERVICES THROUGH LAW ENFORCEMENT AND HOSPITAL RESPONSE RECEIVE SURVIVOR CENTERED, TRAUMA INFORMED, AND CULTURALLY SPECIFIC SERVICES. THE TIMING FOR PERFORMANCE OF THIS AWARD IS 36 MONTHS.

CN FARM TO SCHOOL

NON-COMPETITIVE GRANT TO THE TIDES CENTER

DEVELOPMENT OF A CYTOKINE RELEASE ASSAY AS A DIAGNOSTIC TEST FOR LYME DISEASE

LAB ON A CHIP POINT OF CARE ASSAY FOR THE RAPID SERODIAGNOSIS OF LYME DISEASE

AN ANTIGEN-CAPTURE ASSAY TO SCREEN DONATED BLOOD FOR BABESIA MICROTI

INCREASING SCHOOL FOOD DEMAND IN THE SOU

DEVELOPMENT OF AN ANTIGEN CAPTURE ASSAY FOR BABESIA MICROTI

NON-INVASIVE BRAIN STIMULATION USING TWO-COIL KTMP: SIMULTANEOUS STIMULATION AT TWO CORTICAL TARGETS AND DEEP BRAIN STIMULATION AT A SINGLE TARGET - PROJECT SUMMARY/ABSTRACT NON-INVASIVE BRAIN STIMULATION (NIBS) OFFERS GREAT POTENTIAL TO TREAT MANY BRAIN DISORDERS, AND THERE IS MUCH ROOM FOR IMPROVING METHODS AND, HENCE, EFFICACY. A LACK OF PRECISE SPATIOTEMPORAL CONTROL OVER STIMULATION OUTPUT COMBINED WITH INSUFFICIENT STIMULATION INTENSITY HAVE LIMITED THE ABILITY TO EFFECTIVELY MANIPULATE PATTERNS OF BRAIN ACTIVITY TO PRODUCE RELEVANT PHYSIOLOGICAL AND BEHAVIORAL CHANGE. THERAPEUTIC EFFICACY COULD BE SIGNIFICANTLY IMPROVED BY TARGETING BRAIN NETWORK ACTIVITY VIA STIMULATION OF MULTIPLE CORTICAL SITES SIMULTANEOUSLY OR BY TARGETING SINGLE DEEP BRAIN STRUCTURES, THE LATTER CURRENTLY ACCESSIBLE ONLY THROUGH HIGH-RISK INVASIVE PROCEDURES. THE GOAL OF THIS PROPOSAL IS TO BUILD UPON OUR INNOVATIVE ONE-COIL KILOHERTZ TRANSCRANIAL MAGNETIC PERTURBATION (KTMP) NIBS SYSTEM BY DEVELOPING A TWO-COIL KTMP SYSTEM AS A RESPONSE TO THIS URGENT CLINICAL NEED. KTMP UNLOCKS A PREVIOUSLY UNTAPPED NIBS DOMAIN BY DELIVERING HIGH-AMPLITUDE, NARROW- BAND ELECTRIC FIELD STIMULI IN THE KILOHERTZ RANGE (1-5 KHZ) TO PRECISELY TARGETED BRAIN REGIONS. THIS ADVANCED SYSTEM WILL, FOR THE FIRST TIME, ENABLE THE FREQUENCY-SPECIFIC MANIPULATION OF NEURAL ACTIVITY AT TWO CORTICAL POINTS SIMULTANEOUSLY OR WITHIN A SINGLE SUBCORTICAL AREA, ACHIEVING STIMULATION INTENSITIES UNATTAINABLE WITH EXISTING METHODS WITHOUT DISCOMFORT OR HEALTH RISKS. THE 6-MONTH FUNDING PERIOD WILL BE DEDICATED TO CONSTRUCTING A KTMP AMPLIFIER SYSTEM CAPABLE OF INDEPENDENTLY DRIVING TWO COILS, OPTIMIZING INDUCED ELECTRIC FIELDS FOR SAFE AND ACCURATE DUAL-CORTICAL AND SUBCORTICAL TARGETING, AND IMPLEMENTING A COIL NAVIGATION SYSTEM TO ENSURE PRECISE AND RELIABLE COIL POSITIONING. IF OUR PREDICTIONS HOLD TRUE, A TWO-COIL KTMP SYSTEM MAY DRAMATICALLY ENHANCE THE WAY WE CAN INTERACT WITH THE BRAIN NON-INVASIVELY, REDEFINING THE TREATMENT SPACE OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS.

THE TRANSITIONAL HOUSING ASSISTANCE GRANTS FOR VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING PROGRAM (TRANSITIONAL HOUSING PROGRAM, AUTHORIZED BY 34 U.S.C. 12351), HAS AS ITS PRIMARY PURPOSE THE PROVISION OF TRANSITIONAL HOUSING AND SUPPORT SERVICES TO AID MINORS, ADULTS, AND THEIR DEPENDENTS WHO ARE HOMELESS (AS DEFINED IN 34 U.S.C. 12473(6)) OR IN NEED OF TRANSITIONAL HOUSING OR OTHER HOUSING ASSISTANCE AS A RESULT OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, OR STALKING. THE PROGRAM IS INTENDED TO PROVIDE ASSISTANCE TO VICTIMS FOR WHOM EMERGENCY SHELTER SERVICES OR OTHER CRISIS INTERVENTION SERVICES ARE UNAVAILABLE OR INSUFFICIENT. THE PROGRAM SUPPORTS VICTIM-CENTERED APPROACHES TO PROVIDING TRANSITIONAL HOUSING, SHORT-TERM HOUSING ASSISTANCE, AND VOLUNTARY SUPPORT SERVICES TO ASSIST WITH LOCATING AND SECURING PERMANENT HOUSING, OBTAINING EMPLOYMENT, AND INTEGRATING INTO A COMMUNITY. TIDES OF CHANGE, A NON-PROFIT ORGANIZATION LOCATED IN TILLAMOOK, OREGON, WILL IMPLEMENT THE TILLAMOOK SURVIVOR HOUSING PROJECT THROUGH THE PROVISION OF VICTIM-CENTERED APPROACHES TO TRANSITIONAL HOUSING NEEDS, IN COLLABORATION WITH COMMUNITY ACTION RESOURCE ENTERPRISES. THE PROJECT WILL PROVIDE TWELVE PRIVATE LANDLORD, SCATTERED SITE TRANSITIONAL HOUSING RESIDENCES FOR TWELVE SURVIVORS AND THEIR FAMILIES IN A RURAL REGION OF OREGON. THIS NEW PROJECT WILL USE FUNDS TO PROVIDE BOTH HOUSING AND SUPPORTIVE SERVICES TO MOVE SURVIVORS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, OR STALKING WHO ARE HOMELESS OR IN NEED OF HOUSING ASSISTANCE TO PERMANENT HOUSING. THE PROJECT WILL ASSIST CLIENTS FOR AN ANTICIPATED MINIMUM OF 6 MONTHS AND A MAXIMUM LENGTH OF 24 MONTHS. THE RANGE OF OPTIONAL SUPPORT SERVICES INCLUDES RENTAL ASSISTANCE, VICTIM ADVOCACY, HOUSING ADVOCACY, FINANCIAL/EMPLOYMENT COUNSELING, INDIVIDUAL/GROUP COUNSELING, AND LEGAL ADVOCACY. THE PROJECT WILL HIRE ONE ADDITIONAL STAFF MEMBER TO IMPLEMENT THE PROGRAM AND PROVIDE FOLLOW-UP SERVICES FOR AT LEAST THREE MONTHS ONCE PERMANENT HOUSING IS SECURED.

CONGRESSIONALLY DIRECTED SPENDING - HISTORIC PRESERVATION FUND GRANTS-IN-AID AWARDED THROUGH CONGRESSIONALLY DIRECTED SPENDING ASSIST IN THE IDENTIFICATION, EVALUATION, AND PROTECTION OF HISTORIC PROPERTIES BY SUCH MEANS AS EDUCATION, SURVEY, PLANNING, TECHNICAL ASSISTANCE, PRESERVATION, DOCUMENTATION, AND FINANCIAL INCENTIVES LIKE GRANTS AND TAX CREDITS AVAILABLE FOR HISTORIC PROPERTIES. THE GRANTS SUPPORT A BROAD RANGE OF PRESERVATION PROJECTS FOR HISTORIC PROPERTIES INCLUDING ARCHITECTURAL SERVICES, HISTORIC STRUCTURE REPORTS, PRESERVATION PLANS, AND PHYSICAL PRESERVATION TO SITES IN KEEPING WITH THE SECRETARY OF THE INTERIORS STANDARDS AND GUIDELINES FOR ARCHEOLOGY AND HISTORIC PRESERVATION. BENEFICIARIES INCLUDE STATES, TRIBES, LOCAL GOVERNMENTS AND NONPROFITS AS DESIGNATED BY CONGRESS. THIS PROJECT IS AWARDED TO THE NONPROFIT, QUODDY TIDES FOUNDATION, FOR MASONRY AND ROOF REPAIRS TO THE MASONIC HALL.

SCHOOL-TO-WORK TRAINING FOR AT-RISK YOUTHS

THE TILLAMOOK COMMUNITY-WIDE SANE PROPOSAL WILL EXPAND SEXUAL ASSAULT (SA) RESPONSE IN ORDER TO PROVIDE TRAUMA-INFORMED SERVICES FOR ALL SURVIVORS OF SA. THIS PROJECT WILL INCREASE THE CAPACITY FOR SEXUAL ASSAULT FORENSIC EXAMS (SAFES) TO BE PROVIDED BY SEXUAL ASSAULT NURSE EXAMINERS (SANES) ACROSS TILLAMOOK COUNTY THROUGH A COLLABORATIVE COMMUNITY-BASED PARTNERSHIP. THE SERVICE AREA WHERE THIS PROJECT WILL BE IMPLEMENTED IS TILLAMOOK COUNTY, OREGON. TILLAMOOK COUNTY IS LOCATED ON THE NORTH OREGON COAT WITH A POPULATION OF 27,748 RESIDING IN A LAND AREA OF 1,133 MILES OF MOSTLY MOUNTAINOUS TIMBERLAND WITH A STRIP OF BEACH THAT STRETCHES MORE THAN 70 MILES. KEY ACTIVITIES WILL BE TO REVIEW PROTOCOLS AND REDEVELOP A FORMALIZED AND SUSTAINABLE COMMUNITY PARTNERSHIP MODEL, WHICH WILL SUPPORT SUSTAINABLE RECRUITMENT, TRAINING AND RETENTION OF SANES.  THIS GRANT WILL SUPPORT A .5FTE COMMUNITY RESPONSE COORDINATOR AND .1FTE EXECUTIVE DIRECTOR, EMPLOYED BY OUR DOMESTIC AND SEXUAL VIOLENCE AGENCY, TIDES OF CHANGE, WHO WILL PROVIDE LEADERSHIP AND COORDINATION OF THE ACTIVITIES DETERMINED NECESSARY TO FULLY DEVELOP, IMPLEMENT AND INSTITUTIONALIZE SA RESPONSE. THIS PROJECT WILL ALSO FUND FTE OF A DEDICATED SANE WITH ADVENTIST HEALTH TILLAMOOK. THE EXPECTATION IS THAT THE AMOUNT OF SA VICTIMS THAT ACCESS MEDICAL SERVICES FOR SAFES WILL INCREASE OVER THE 3 YEARS OF THIS PROJECT AND THE DEDICATED SANE FTE WILL INCREASE EACH YEAR FROM .35FTE TO .5FTE. ADDITIONAL PROJECT PARTNERS ARE TILLAMOOK COUNTY COMMUNITY HEALTH CENTER AND THE RINEHART CLINIC, WHO WILL PARTNER TO INCREASE SANES. THE ON-CALL ROTATION HOURS WILL BE FUNDED BY THIS PROJECT. OUR GOAL BY THE END OF THIS PROJECT IS TO EXPAND AND SUSTAIN SANE CAPACITY FROM ZERO AS OF JUNE 2022 TO 4 AS OF JUNE 2024. THESE ACTIVITIES WILL SUPPORT STRONGER, MORE CONSISTENT INVOLVEMENT OF ADVOCATES THROUGHOUT THE CONTINUUM OF CARE AS WELL AS ENHANCE COLLABORATIVE POST-SEXUAL ASSAULT CARE SUCH AS MEDICAL SERVICES, WRAPAROUND SUPPORT, AND LEGAL REMEDIES. THE ULTIMATE DESIRED OUTCOMES ARE TO ACHIEVE A CONSISTENT, SUPPORTIVE, TRAUMA-INFORMED PARTNERSHIP RESPONSE TO SURVIVORS OF SA THAT ENHANCES THE HEALTH AND WELL-BEING OF SURVIVORS, INCREASES THE LEVEL OF ACCOUNTABILITY FOR SEXUAL ASSAULT OFFENDERS, AND INCREASES THE OVERALL SAFETY AND WELL-BEING OF THE COMMUNITY AS A WHOLE. THOSE WHO WILL BE DIRECTLY IMPACTED ARE VICTIMS OF SA WHO ACCESS THE HEALTHCARE SYSTEM OR OTHERS PROVIDERS IN THE SEXUAL ASSAULT RESPONSE TEAM. THE CAPACITY BUILDING, SYSTEMIC COORDINATION AND GREATER KNOWLEDGE THAT ARE PRODUCED THROUGH THIS PROJECT WILL BENEFIT ALL OF TILLAMOOK COUNTY.

PET IMAGING TO EVALUATE A NOVEL CHEMOKINE ANTAGONIST TO PROTECT SYNAPSES IN ADRD - 7. PROJECT SUMMARY ADRD DEMENTIAS ACCOUNT FOR UP TO 25% OF ALL DEMENTIAS IN PATIENTS OLDER THAN 65 YEARS AND THERE IS STRONG EVIDENCE OF CO-MORBID PATHOLOGIES CAUSED BY (AMYLOID SS (ASS), TAU AND A-SYNUCLEIN (ASYN). THE DEGREE OF AD- RELATED PATHOLOGY IN LEWY BODY DEMENTIAS (LBD) IS MODERATE OR SEVERE IN 50% OF PDD AND MORE THAN 70% OF DLB PATIENTS HAVE CONCOMITANT AD-RELATED PATHOLOGY SO THAT THESE PATIENTS EXPERIENCE A MORE HETEROGENEOUS, FASTER, AND SEVERE CLINICAL PHENOTYPE. COGNITIVE IMPAIRMENT IS CLOSELY ASSOCIATED WITH SYNAPSE LOSS WHICH OCCURS SIGNIFICANTLY PRIOR TO NEURONAL LOSS SUGGESTING THAT SYNAPTIC DYSFUNCTION IS THE KEY TREATMENT TARGET AND THAT ULTIMATELY SYNAPSE LOSS BY MULTIPLE TOXIC OLIGOMERS (ASYN, ASS, AND TAU), THAT BEGINS WITH THEIR BINDING TO PRPC, MUST BE STOPPED. OUR RESULTS SHOW THAT RAP-103, A SMALL ORAL PEPTIDE CCR5 ANTAGONIST POTENTLY PREVENTS BOTH ASYN AND ASS-MEDIATED SPINE AND SYNAPSE LOSS IN RODENT AND HUMAN NEURONS BY BLOCKING PRPC ACTIVATION THAT DISRUPTS MICROTUBULES, SPINE STRUCTURE AND SYNAPSE FUNCTION. RAP-103 PROTECTED RODENT AND HUMAN NEURON SPINES AND SYNAPSES FROM ASYN AND ASS-INDUCED LOSS, AND IN A PILOT STUDY OF THE HUMAN ASYN EXPRESSING ANIMAL MODEL LINE 6116, PREVENTED COGNITIVE DEFICITS. BY BINDING TO NEURONAL CCR5, RAP-103 EXERTS AN ALLOSTERIC INHIBITORY EFFECT ON MEMBRANE BOUND PRPC/NOX COMPLEX ACTIVATION TO BLOCK MULTIPLE TOXIC OLIGOMERS TO STOP, POSSIBLY REVERSE, SYNAPSE LOSS AND COGNITIVE DECLINE IN ADRD INCLUDING LBD. UTILIZING THE TG4510 MIXED A- SYN/TAUOPATHY ANIMAL MODEL WE WILL CONDUCT A DEFINITIVE IN VIVO STUDY OF RAP-103 PROTECTIVE EFFECTS ON SYNAPSE DENSITY AND DISEASE BIOMARKERS RELEVANT TO ADRDS BY BRAIN HISTOCHEMICAL ANALYSIS. WE WILL COMPARE IN VIVO HISTOCHEMICAL ANALYSIS OF SYNAPSE DENSITY TO LIVE ANIMAL SV2A PET IMAGING WITH [18F]SYNVEST-1 AS A QUANTITATIVE BIOMARKER OF SYNAPTOGENESIS. WE WILL ADMINISTER RAP-103 BY ORAL DOSING FROM MONTHS 6 TO 7 WHEN ANIMALS EXPERIENCE SYNAPSE LOSS. WE WILL DETERMINE RAP-103 EFFECTS ON MARKERS OF BRAIN SYNAPSE DENSITY IN CORTEX AND HIPPOCAMPUS BY QUANTITATIVE METHODS MEASURING EXPRESSION OF SYNAPTOPHYSIN 1, A SYNAPTIC VESICLE PROTEIN AND SVA2, THE TARGET OF THE PET IMAGING TRACER AND NORMALIZE TO TOTAL NEURON DENSITY WITH NEUN IN PRE- IDENTIFIED REGIONS OF INTEREST. WE WILL ALSO DETERMINE RAP-103 EFFECTS ON DISEASE BIOMARKERS BY MEASURING THE NUMBER OF NEUROFIBRILLARY TANGLES-NFT LOAD, OLIGOMERIC TAU, PTHR231TAU, MULTIMERIC TOTAL ASYN AND PSER129 ASYN. SUCCESSFUL COMPLETION OF THE AIMS WILL SUPPORT FURTHER DEVELOPMENT OF RAP-103 FOR SYNAPSE PROTECTING EFFECTS AND SUGGEST USING SV2A PET IMAGING WITH [18F]SYNVEST-1 AS A QUANTITATIVE BIOMARKER OF SYNAPTOGENESIS IN ADRDS, WHICH CAN THEN BE CORRELATED WITH BIOMARKERS AND COGNITIVE BENEFITS FOR USE IN HUMAN TESTING.

OPTIMIZATION OF A CHEMOKINE RECEPTOR ANTAGONIST PEPTIDE AS A SYNAPSE PROTECTING TREATMENT FOR NEURODEGENERATION IN ALZHEIMER'S DISEASE - 7. PROJECT SUMMARY AD IN RESPONSE TO PAS-19-319, CREATIVE BIO-PEPTIDES, INC. PROPOSES A NOVEL THERAPEUTIC APPROACH TO PROTECT AND RESTORE SYNAPSES IN ALZHEIMER’S DISEASE (AD) BY BLOCKING MULTIPLE CHEMOKINE RECEPTORS THAT PROMOTE SYNAPSE LOSS AND INHIBIT THEIR REGENERATION. FUNCTIONAL IMPAIRMENT IN AD RESULTS FROM LOSS OF NEURONAL SPINES AND DENDRITES, PRECEDING AND INDEPENDENT OF NEURONAL DEATH. COFILIN-ACTIN RODS (RODS) ARE A 1:1 COMPLEX OF ACTIN AND COFILIN WHOSE FORMATION IS LINKED TO A CELLULAR PRION PROTEIN (PRPC) AND NADPH OXIDASE (NOX)-DEPENDENT SIGNALING PATHWAY AND REPRESENTS AN EARLY AD PATHOLOGY. RODS FORM IN NEURITES UNDER CONDITIONS OF ENERGETIC AND OXIDATIVE STRESS, SUCH AS OCCUR IN NEUROINFLAMMATION, AND LEAD TO NEURITE DISTAL ATROPHY. SYNAPSE FUNCTION DECLINES IN NEURITES IN WHICH RODS HAVE FORMED COMPARED NEURITES WITHOUT RODS FROM THE SAME NEURON AND RODS ARE SIGNIFICANTLY INCREASED IN ANIMAL MODELS OF AD AND IN HUMAN AD BRAIN. CONVERSELY, COGNITIVE DEFICITS IN MOUSE MODELS OF AD ARE ALLEVIATED BY DECREASING COFILIN RODS IN NEURONS. COFILIN PLAYS IMPORTANT ROLES IN DENDRITIC SPINE DYNAMICS AND RECEPTOR TRAFFICKING AND THE SEQUESTERING OF COFILIN INTO RODS IS DETRIMENTAL TO SYNAPTIC FUNCTION. OUR PRELIMINARY DATA SHOWS THAT NEW ORAL, STABLE AND RAPIDLY BRAIN PENETRANT PEPTIDE ANALOGS OF THE CLINICAL USE MULTI-CHEMOKINE RECEPTOR ANTAGONIST (MCRA) DAPTA (DALA1-PEPTIDE T-AMIDE) INHIBIT THE FORMATION OF ASSD/T (1 NM)-INDUCED COFILIN-ACTIN RODS AND ARE NEUROPROTECTIVE. DAPTA REDUCED MICROGLIAL ACTIVATION IN THE DENTATE GYRUS, PREVENTED CORTICAL NEURONAL LOSS IN NBM-LESIONED AGED ANIMALS AND PROMOTED ROBUST SPROUTING OF AXONS AND SYNAPSE REGENERATION IN ANIMALS. IN MULTIPLE PHASE 2 TRIALS CONDUCTED BY THE NIH ON SUBJECTS WITH HIV-ASSOCIATED NEUROCOGNITIVE DISORDERS (HAND), DAPTA NORMALIZED FUNCTIONAL BRAIN SCANS AND REVERSED COGNITIVE DEFICITS IN PHASE 2 TRIALS BY CHEMOKINE RECEPTOR BLOCKING MECHANISMS RELATED TO PREVENTING COFILIN ROD FORMATION AND PROTECTING SYNAPSES. THE SYNAPSE AND NEURITE EXTENDING EFFECTS OF CHEMOKINE BLOCKADE WERE RECENTLY ALSO SHOWN FOR MARAVIROC IN BRAIN INJURIES CONFIRMING CHEMOKINE RECEPTORS AS TRANSLATIONAL TARGETS FOR DRUG DEVELOPMENT. DAPTA WAS SAFE IN OVER 600 PERSONS, SOME FOR AS LONG AS TEN YEARS HOWEVER WAS NOT STABLE AS A NASAL SPRAY FORMULATION. IT TOOK US MANY YEARS TO CREATE NEW STABLE ORAL ANALOGS OF DAPTA WITH BETTER BRAIN ENTRY AND LONG HALF-LIFE AND NOW PROPOSE TO OPTIMIZE A LEAD ORAL PEPTIDE FOR SYNAPSE PROTECTING AND RESTORING BENEFITS IN AD BY DETERMINING THE EC50 VALUES FOR FOUR ORAL PEPTIDES TO INHIBIT FORMATION OF ASSD/T-INDUCED COFILIN RODS COMPARED TO APPROVED CRA’S MARAVIROC AND AMD3100 IN PRIMARY MOUSE HIPPOCAMPAL NEURONAL CULTURES. WE WILL FURTHER OPTIMIZE THE NEUROPROTECTIVE EFFECTS OF PEPTIDES IN ASSD/T-TREATED NEURONS THROUGH QUANTIFIABLE MORPHOLOGICAL AND ARCHITECTURAL ASSESSMENTS OF SYNAPSE MORPHOLOGY. ONCE WE HAVE IDENTIFIED THE OPTIMIZED PEPTIDE, WE WILL DETERMINE THE SAFETY AND TOXICOKINETIC PROFILE AND CONFIRM BRAIN ENTRY AS A PRELUDE TO FUTURE IND- ENABLING STUDIES.

CN FARM TO SCHOOL GRANT

TO SUPPORT HE PARTICIPATION OF CIVIL SOCIETY ORGANIZATIONS (CSOS) IN THE OPEN GOVERNMENT PARTNERSHIP PROCESS, BOTH DOMESTICALLY AND INTERNATIONALLY.

DEVELOPMENT OF A NOVEL CHEMOKINE RECEPTOR ANTAGONIST PEPTIDE AS A SYNAPSE PROTECTING TREATMENT FOR NEURODEGENERATION IN ALZHEIMER'S DISEASE

COOPERATIVE RESEARCH IN PLANETARY ASTRONOMY: THIS PROPOSAL REQUESTS SUPPORT FOR ASTRONOMICAL AND LA

CN FARM TO SCHOOL GRANT

COMPETITIVE AWARD AGREEMENT REQUIREMENTSFUNDING OPPORTUNITY NUMBER: P23AS00031 FUNDING OPPORTUNITY GOALS TEXT:THE JAPANESE AMERICAN CONFINEMENT SITES (JACS) GRANT PROGRAM (PUBLIC LAW 109-441, 120 STAT. 3288) PROVIDES FINANCIAL ASSISTANCE TO ORGANIZATIONS AND ENTITIES WORKING TO PRESERVE HISTORIC JAPANESE AMERICAN CONFINEMENT SITES AND THEIR HISTORY, INCLUDING: PRIVATE NONPROFIT ORGANIZATIONS EDUCATIONAL INSTITUTIONS STATE, LOCAL, AND TRIBAL GOVERNMENTS AND OTHER PUBLIC ENTITIES, FOR THE PRESERVATION AND INTERPRETATION OF U.S. CONFINEMENT SITES WHERE JAPANESE AMERICANS WERE DETAINED DURING WORLD WAR II. REQUIREMENTS FOR ALL AGREEMENTS:PURPOSE OF AWARD: OVERARCHING GOAL. TO PRESERVE AND INTERPRET THE HISTORY AND IMPACTS OF JAPANESE AMERICAN INCARCERATION DURING WORLD WAR II. OBJECTIVES. TO COMPLETE PLANNING FOR CONSTRUCTION OF VISITOR CENTER TO SHARE THE HISTORY OF JAPANESE AMERICANS DURING WORLD WAR II. SUMMARY OF PROJECT SPECIFIC ACTIVITIES:THE TIDES CENTER NATIONAL VETERANS NETWORK (NVN), IN PARTNERSHIP WITH THE NATIONAL MUSEUM OF THE U.S. ARMY AND THE ARMY HISTORICAL FOUNDATION, WILL ENHANCE AN EXISTING EXHIBIT TO CREATE A TRAVELING EXHIBITION CALLED NISEI SOLDIER EXPERIENCE: TWO FRONT WAR. THE EXHIBIT WILL RAISE AWARENESS OF THE PATRIOTISM AND LOYALTY OF JAPANESE AMERICANS WHO ENLISTED FOR WWII MILITARY SERVICE WHILE INCARCERATED IN CONFINEMENT SITES, FACING A TWO FRONT WAR FOR AMERICAN DEMOCRACY BOTH ABROAD AND AT HOME. THE NVN WILL RESEARCH COLLECT NEW OBJECTS, IMAGES, AND STORIES DESIGN FABRICATE AND LAUNCH THE EXHIBIT THAT WILL BE HOSTED AT TEN VENUES ACROSS THE U.S. WITH AN ONLINE VERSION ACCESSIBLE VIA THE NATIONAL MUSEUM OF THE U.S. ARMY.PERFORMANCE GOALS INCLUDING MILESTONES AND EXPECTED OUTCOMES:COMPLETE COLLECTION OF ARTIFACTS DEVELOP ONLINE EXHIBIT DESIGN AND FABRICATE TRAVELING EXHIBIT TO BE SHOWN AT 10 VENUES, REACHING APPROXIMATELY 500,000 VISITORS.2.BENEFICIARIES:THE PUBLIC EDUCATORS NPS JACS SITES ORGANIZATIONS PRESERVING JACS SITES AND HISTORY

EDI SPECIAL PROJECTS

A NOVEL CHEMOKINE RECEPTOR ANTAGONIST TO BLOCK OPIOID REINFORCEMENT, RELAPSE AND PHYSICAL DEPENDENCE

INDIGITIZE COMPUTER SCIENCE COALITION -THIS PROJECT SUPPORTS THE BROADENING OF PARTICIPATION OF TRADITIONALLY UNDERSERVED POPULATIONS IN HIGH QUALITY COMPUTER SCIENCE (CS). THE RESEARCH WILL PROVIDE CRITICAL INSIGHTS FOR DEVELOPING AND SCALING CS EXPERIENCES WITH INDIGENOUS COMMUNITIES AND SCHOOLS. THE LONG TERM GOAL OF THE PROJECT IS TO EXPAND CS EDUCATION ACCESS FOR AMERICAN INDIAN/ALASKA NATIVE (INDIGENOUS) MIDDLE-SCHOOL STUDENTS, GRADES 6-8. THIS RESEARCHER-PRACTITIONER PARTNERSHIP (RPP), LED BY ONE GENERATION (ONE GEN) AND SUPPORTED BY THE AMERICAN INSTITUTES FOR RESEARCH (AIR) AND THE NATIVE AMERICAN COMMUNITY ACADEMY (NACA), SEEKS TO ADDRESS THE SIGNIFICANT DISPARITIES IN CS EDUCATION AMONG INDIGENOUS STUDENTS. BY ADAPTING AND DEVELOPING CULTURALLY RELEVANT CS AND COMPUTATIONAL THINKING (CT) INSTRUCTIONAL MATERIALS, AND TEACHER PROFESSIONAL DEVELOPMENT PROGRAMS, THE PROJECT TEAM WILL HELP ENSURE THAT INDIGENOUS STUDENTS SEE THEIR LANGUAGE, CULTURE, AND VALUES REFLECTED IN THEIR COMPUTING EDUCATION. THE PROJECT BUILDS ON ONE GEN'S SUCCESSFUL INDIGITIZE COMPUTER SCIENCE PROGRAM AND AIR'S NSF-FUNDED WIND RIVER ELEMENTARY COMPUTER SCIENCE COLLABORATIVE, ADDRESSING CRITICAL GAPS IN CS EDUCATION AND CONTRIBUTING VALUABLE INSIGHTS INTO THE DEVELOPMENT AND IMPLEMENTATION OF CULTURALLY-RESPONSIVE STEM (SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS) K-12 CURRICULA. THE PROJECT FOCUSES ON THREE MAIN OBJECTIVES: (1) CULTURALLY ADAPTING EXISTING CS CONTENT TO CREATE A ONE-SEMESTER FOUNDATIONAL COURSE FOR MIDDLE SCHOOL STUDENTS AT NACA, AIMING TO SERVE 60 STUDENTS; (2) DEVELOPING AND PILOTING PROFESSIONAL DEVELOPMENT PROGRAMS FOR NACA TEACHERS TO INTEGRATE CULTURALLY SUPPORTIVE CS/CT CONTENT ACROSS VARIOUS SUBJECTS, INCLUDING INDIGENOUS LANGUAGE ARTS, REACHING 8 TEACHERS AND 140 STUDENTS; AND (3) ESTABLISHING THE RESEARCH-PRACTICE PARTNERSHIP (RPP) TO FOSTER COLLABORATION, BUILD RESEARCH CAPACITY, AND LAY THE GROUNDWORK FOR SCALING THE PROGRAM TO ADDITIONAL GRADES AND SCHOOLS. THESE OBJECTIVES WILL BE INVESTIGATED VIA THE RESEARCH QUESTION: WHAT ARE THE CONDITIONS NECESSARY TO BUILD AN INDIGENOUS CS-FOCUSED RESEARCHER-PRACTITIONER PARTNERSHIP THAT IS COMPRISED OF A NETWORK OF INDIGENOUS CS-FOCUSED SCHOOLS AND PARTNERS? THE PROJECT THEORY OF CHANGE ADDRESSES THREE PRIMARY CHALLENGES IN CS EDUCATION FOR INDIGENOUS YOUTH: ACCESS, QUALITY, AND CULTURE. THE PROJECT'S DESIGN IS GROUNDED IN A THEORETICAL FRAMEWORK THAT EMPHASIZES COMMUNITY-LED TRANSFORMATION, CULTURALLY RELEVANT CONTENT, HOLISTIC LEARNING ECOSYSTEMS, AND REFLECTIVE PRACTICE. TO ADDRESS INDIGENOUS STUDENT NEEDS, THE PROJECT TEAM WILL ENGAGE TEACHERS AND SCHOOL LEADERS IN COLLABORATIVE PLANNING TO ENHANCE PROGRAMMATIC GROWTH AND SUPPORT EDUCATORS THROUGH COMPREHENSIVE TRAINING AND PEER LEARNING. THE PROJECT TEAM WILL INTEGRATE CS LEARNING UNITS ACROSS MULTIPLE TOUCHPOINTS, INCLUDING STAND-ALONE CLASSES AND INTERDISCIPLINARY PROJECTS. BY LEVERAGING HIGH-QUALITY, ADAPTABLE CONTENT LIKE MIT'S SCRATCH TUTORIALS AND FOSTERING A COMMUNITY-ORIENTED APPROACH TO EDUCATION, THE PROJECT AIMS TO CREATE CULTURALLY-RESPONSIVE AND ENGAGING CS EXPERIENCES THAT INSPIRE BOTH TEACHERS AND STUDENTS. THE PROFESSIONAL DEVELOPMENT STRATEGIES ARE DESIGNED TO BE SCALABLE WHILE RETAINING THE FLEXIBILITY FOR COMMUNITY-LED DESIGN AND CULTURAL ADAPTATION, ENSURING THE CS EDUCATION PROVIDED IS BOTH RELEVANT AND IMPACTFUL FOR INDIGENOUS STUDENTS. TO ASCERTAIN THE LEVEL OF SUCCESS, THE PROJECT TEAM WILL USE QUALITATIVE DATA FROM MULTIPLE SOURCES INCLUDING TEACHERS, CLASSROOM LESSON SAMPLES, STUDENTS AND MEMBERS OF THE RPP. FOR EXAMPLE, A SERIES OF SEMI-STRUCTURED TEACHER INTERVIEWS WILL BE ANALYZED USING A COMBINATION OF INDUCTIVE AND DEDUCTIVE CODING. TEACHER CLASSROOM LESSON PLANS AND REFLECTIVE ENACTMENT SURVEYS WILL ALSO BE COLLECTED AT MULTIPLE JUNCTURES DURING THE PROJECT. FINDINGS FROM THESE DATA SOURCES WILL BE USED TO DETERMINE TEACHER IMPLEMENTATION PATTERNS, HIGHLIGHTING BOTH AREAS OF SUCCESS AS WELL AS CHALLENGES. THIS PROJECT IS FUNDED THROUGH THE COMPUTER SCIENCE FOR ALL: RESEARCH AND RPPS PROGRAM. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

OCEAN TIDES SCHOOL COMPUTER & SCIENCE LAB/CLASSROOMS

FIE EARMARK GRANT AWARDS

THE PROPOSED PROJECT WILL ENABLE THE NATIONAL FARM TO SCHOOL NETWORK (NFSN) TO COLLABORATE WITH ESTABLISHED PARTNERS ON THE GROUND IN THREE SCHOOL COMMUNITIES: HARDIN SCHOOL DISTRICT 17H&1 IN CROW RESERVATION, MONTANA; INDIAN TOWNSHIP SCHOOL IN INDIAN TOWNSHIP, MAINE; AND MALAAI KULA IN KAUA'I, HAWAI'I. THE PROPOSED PROJECT WILL SCALE UP AND INSTITUTIONALIZE CULTURALLY SIGNIFICANT FARM TO SCHOOL PROGRAMS THROUGHOUT THE ENTIRE SCHOOL ENVIRONMENT AND ULTIMATELY IMPROVE THE NUTRITIONAL HEALTH AND WELLNESS OF NATIVE YOUTH. THIS PROJECT WILL BUILD UPON THE SUCCESS OF NFSN'S PREVIOUS WORK WITH NATIVE COMMUNITIES. WORKING WITH NATIVE PARTNERS, NFSN CONTINUES ADDRESSING THE UNIQUE OPPORTUNITIES AND CHALLENGES OF EXPANDING AND SUSTAINING FARM TO SCHOOL IN NATIVE COMMUNITIES ACROSS THE COUNTRY. FARM TO SCHOOL IS A NEW TERM FOR AN ANCIENT CONCEPT THAT EMBRACES INDIGENOUS KNOWLEDGE AND VALUES IN HARMONY WITH TRADITIONAL NATIVE LIFEWAYS, AND HAS PROVEN POSITIVE RESULTS ON HEALTH,EDUCATION, AND HUNGER. IN NATIVE COMMUNITIES, FARM TO SCHOOL IS ROOTED IN INDIGENOUS KNOWLEDGE TO TRANSFORM SCHOOL ENVIRONMENTS INTO CENTERS OF CULTURAL EDUCATION. THIS LEARNING TAKES PLACE IN OUTDOOR EDUCATIONAL SETTINGS SUCH AS SCHOOL GARDENS AND ORCHARDS, CULINARY PROGRAMS TEACHING TRADITIONAL FOODWAYS LIKE FORAGING AND PRESERVATION, AND SCHOOL CAFETERIAS SERVING INDIGENOUS FOODS TO EAGER STUDENTS WHO ARE RE-ESTABLISHING RELATIONSHIPS WITH TRADITIONAL FOODS. NFSN'S SEED CHANGE IN NATIVE COMMUNITIES PROGRAM WORKS AT THE LOCAL LEVEL TO EXPAND FARM TO SCHOOL ACTIVITIES (PROCUREMENT OF LOCAL AND TRADITIONAL FOODS, SCHOOL GARDENS, AND AGRICULTURE AND NUTRITION EDUCATION) FOR STUDENTS IN SCHOOL COMMUNITIES SERVING NATIVE AMERICAN YOUTH. NFSN'S SEED CHANGE PROGRAM MODEL IS BASED UPON HONORING LOCAL LEADERSHIP AND AUTONOMY THROUGH CAPACITY BUILDING TO SUPPORT THE COMMUNITY'S VISION AND TO ENSURE SUSTAINABLE PROGRESS. NFSN'S WORK IS GUIDED BY THE FOLLOWING ESSENTIAL LESSONS:THERE IS NO ONE-SIZE-FITS ALL SOLUTION TO CREATING HEALTHIER COMMUNITIES, AND THIS IS PARTICULARLY TRUE IN NATIVE COMMUNITIES WHERE CULTURAL CONTEXT MUST BE FULLY INTEGRATED INTO EFFORTS TO ENSURE THEIR EFFECTIVENESS AND LONG-TERM SUSTAINABILITY.BECAUSE COMMUNITIES AND SCHOOLS ARE SO DIVERSE, THERE ARE NO BEST PRACTICES FOR FARM TO SCHOOL IN NATIVE COMMUNITIES, BUT THERE ARE SHARED VALUES, INCLUDING:HOMEGROWN SOLUTIONS WORK BEST,SELF-SUFFICIENCY SUPPORTS WHOLE-PERSON AND COMMUNITY HEALTH,LOCAL HERITAGE IS HONORED THROUGH TRADITIONAL FOODS,YOUTH EMPOWERED AS LEADERS IN THE SCHOOL COMMUNITY CREATES LASTING CHANGE,PRACTITIONERS LEARN THROUGH EXPERIENCE, PRIORITIZE RELATIONALITY, AND LEAD THROUGH CULTURE, ANDTRADITIONAL ECONOMIES ARE EMBRACED AS A STRATEGY FOR ADVANCING FOOD SOVEREIGNTY.THE PROPOSED PROJECT UPLIFTS CULTURALLY SIGNIFICANT FARM TO SCHOOL PROGRAMS AS A STRATEGY TO IMPROVE THE WELLNESS OF NATIVE YOUTH. FARM TO SCHOOL ACTIVITIES ENRICH THE CONNECTION COMMUNITIES HAVE WITH HEALTHY FOOD AND LOCAL FOOD PRODUCERS BY ENHANCING FOOD PURCHASING AND EDUCATION PRACTICES AT SCHOOLS. IT IS WELL ESTABLISHED THROUGH RESEARCH BY NFSN AND OUR PARTNERS THAT FARM TO SCHOOL INFLUENCES INVESTMENT POLICIES AND PRACTICES OF SCHOOLS RESULTING IN EQUITABLE AND SUSTAINABLE ECONOMIES THAT CONTRIBUTE TO HEALTHY COMMUNITIES.

AHLAN 2.0 IS A CULINARY & CULTURAL EXCHANGE SERIES THAT FOSTERS HUMAN INTERACTION. THE PROJECT WILL UTILIZE FOOD DIPLOMACY AND CREATIVITY TO BUILD A MULTILATERAL UNDERSTANDING OF AMERICAN AND TUNISIAN CULTURE.

ONE GENERATION'S INDIGENOUS FARM HUB (IFH) IS A COMMUNITY-BASED INITIATIVE SERVING CENTRAL AND NORTHWEST NEW MEXICO THAT TEACHES INDIGENOUS FARMING TECHNIQUES, FOSTERS FOOD, CULTURAL, AND LAND SOVEREIGNTY WITHIN INDIGENOUS AGRICULTURAL COMMUNITIES, PROVIDES TRAINING AND TECHNICAL ASSISTANCE IN DEVELOPING BUSINESS AND MARKETING PLANS, AND ENGAGES NEW AND BEGINNING FARMERS IN WORK TO IMPROVE ACCESS TO AFFORDABLE, HEALTHY FOOD ACROSS AREAS THAT ARE TRADITIONALLY UNDERSERVED AND MARGINALIZED. THROUGH THIS PROJECT, WE WILL CONDUCT RESEARCH IN THE FORM OF ASSESSMENTS THROUGH PARTNER OUTREACH, COMMUNITY FORUMS, AND DIRECT ENGAGEMENT WITH THE NAVAJO NATION AREAS OF SHIPROCK AND SURROUNDING CHAPTERS INCLUDING NENAHNEZAD IN SAN JUAN COUNTY, CRYSTAL IN MCKINLEY COUNTY, AND RURAL AREAS OF SANDOVAL COUNTY, IN ORDER TO BETTER UNDERSTAND THE NEEDS OF INDIGENOUS COMMUNITIES WHICH EXPERIENCE FOOD SCARCITY AND INSTABILITY, ALONG WITH LIMITED DISTRIBUTION MARKETS. THIS RESEARCH WILL BE FOLLOWED BY A FEASIBILITY STUDY THAT WILL HELP US DETERMINE THE POSSIBLE BEST PRACTICES FOR IMPROVED FOOD DISTRIBUTION AT A REGIONAL LEVEL, RESULTING IN THE DEVELOPMENT OF A COMMUNITY-SUPPORTED AGRICULTURE (CSA) DISTRIBUTION AND MARKETING PLAN, INCLUDING OPPORTUNITIES FOR VALUE-ADDED AGRICULTURAL PRODUCTION. OUR ULTIMATE GOAL IS TO CREATE AN INFLUX OF TRAINED AND SUPPORTED FARMERS THROUGHOUT NEW MEXICO, WITH OUTCOMES INCLUDING FIRST DEVELOPING NEW MARKET OPPORTUNITIES FOR FARM AND RANCH OPERATIONS SERVING LOCAL MARKETS; THEN ESTABLISHING AND EXPANDING A LOCAL FOOD BUSINESS ENTERPRISETHROUGH DEVELOPMENT OF A COOPERATIVE REGIONAL CSA NETWORK THAT CONNECTS AGRICULTURAL ENTERPRISES IN CENTRAL AND NORTHWEST NEW MEXICO, AND, FINALLY, IMPROVING ACCESS TO HEALTHY AND FRESH FOODS IN COMMUNITIES THAT ARE UNDER-RESOURCED.

FUNDING OPPORTUNITY NUMBER P21AS00034FUNDING OPPORTUNITY GOALS TEXT THE JAPANESE AMERICAN CONFINEMENT SITES JACS GRANT PROGRAM PUBLIC LAW 109 441, 120 STAT 3288 PROVIDES FINANCIAL ASSISTANCE TO ORGANIZATIONS AND ENTITIES WORKING TO PRESERVE HISTORIC JAPANESE AMERICAN CONFINEMENT SITES AND THEIR HISTORY, INCLUDING PRIVATE NONPROFIT ORGANIZATIONS EDUCATIONAL INSTITUTIONS STATE, LOCAL, AND TRIBAL GOVERNMENTS AND OTHER PUBLIC ENTITIES, FOR THE PRESERVATION AND INTERPRETATION OF U S CONFINEMENT SITES WHERE JAPANESE AMERICANS WERE DETAINED DURING WORLD WAR II REQUIREMENTS FOR ALL AGREEMENTSPURPOSE OF AWARD SUMMARY OF THE GOALS AND OBJECTIVES OF THE PROJECT OVERARCHING GOAL TO PRESERVE AND INTERPRET THE HISTORY AND IMPACTS OF JAPANESE AMERICAN INCARCERATION DURING WORLD WAR II OBJECTIVES TO TRAIN TEACHERS IN CURRICULA ABOUT THE JAPANESE AMERICAN WWII CONFINEMENT SITES AND NISEI SOLDIERS WHO VOLUNTEERED FOR MILITARY SERVICE FROM CONFINEMENT SITES SUMMARY OF PROJECT SPECIFIC ACTIVITIES TIDES CENTER S NATIONAL VETERANS NETWORK WILL HOST A TEACHER TRAINING INSTITUTE TO INSTRUCT TEACHERS, BOTH IN PERSON AND VIRTUALLY, ON CURRICULA TO TEACH ELEMENTARY AND MIDDLE SCHOOL STUDENTS ABOUT THE HISTORY OF JAPANESE AMERICAN WORLD WAR II INCARCERATION AND THE NISEI SOLDIERS WHO VOLUNTEERED FOR MILITARY SERVICE WHILE THEIR FAMILIES REMAINED INCARCERATED BEHIND BARBED WIRE THE THREE DAY INSTITUTE WILL BE HELD AT THE SMITHSONIAN IN WASHINGTON, D C THROUGH THESE EFFORTS, MORE THAN 2,400 STUDENTS WILL LEARN ABOUT THIS HISTORY, WITH THE VIRTUAL COMPONENT REACHING EVEN MORE STUDENTS NATIONWIDE PERFORMANCE GOALS INCLUDING MILESTONES AND EXPECTED OUTCOMES DEVELOPMENT OF TEACHER TRAINING INSTITUTE CONTENT IN PERSON AND VIRTUAL , FACILITATION OF A THREE DAY INSTITUTE AT THE SMITHSONIAN INSTITUTE IN WASHINGTON, DC AND PRODUCTION OF VIRTUAL INSTITUTE TRAINING TO TEACH 120 TEACHERS AND REACH AT LEAST 2,400 STUDENTS BENEFICIARIES THE PUBLIC EDUCATORS NPS JACS SITES ORGANIZATIONS PRESERVING JACS SITES AND HISTORY

PEPTIDE-BASED MULTIPLEX ASSAY FOR LYME DISEASE SERODIAGNOSIS

A RAPID POINT-OF-CARE ASSAY FOR THE DIAGNOSIS OF LYME DISEASE

INTENSIVE OUTPATIENT PROGRAM: TO ADDRESS THE TREATMENT NEEDS OF YOUTH WHO HAD HISTORICALLY BEEN UNSUCCESSFUL IN BEING MAINTAINED IN THEIR HOMES. - TIDES FAMILY SERVICES’ IS REQUESTING FUNDS TO SUPPORT THE INTENSIVE OUTPATIENT PROGRAM (IOP). THIS PROGRAM WAS DEVELOPED TO ADDRESS THE TREATMENT NEEDS OF YOUTH WHO HAD HISTORICALLY BEEN UNSUCCESSFUL IN BEING MAINTAINED IN THEIR HOMES. THE IOP IS A STRUCTURED TREATMENT PROGRAM DESIGNED TO PROVIDE INTENSIVE SUPPORT AND THERAPY FOR YOUTH STRUGGLING WITH TRUANCY, SUBSTANCE ABUSE, ADDICTION, OR CERTAIN BEHAVIORAL HEALTH ISSUES. THE DESCRIPTION PROVIDED HERE IS BASED ON THE AMERICAN SOCIETY OF ADDICTION MEDICINE CRITERIA, SPECIFICALLY VERSION 2.1. IOP SERVICES ARE LOCATED IN PAWTUCKET, RI, AND ARE AVAILABLE TO YOUTH AND FAMILIES THROUGHOUT THE STATE. THE IOP PROGRAM SERVES YOUTH FROM A VARIETY OF CULTURAL AND SOCIOECONOMIC BACKGROUNDS EXPERIENCING A WIDE RANGE OF BEHAVIORAL, SOCIAL, HEALTH/MENTAL HEALTH, EDUCATIONAL/VOCATIONAL, AND FAMILY PROBLEMS.

HUMANITARIAN ACTIVITIES

COMPRENSIVE TORTURE TREATMENT SERVICES AND CAPACITY BUILDING PROJECT

ESTIMATED TOTAL FUNDS REFER TO THE FUNDS AVAILABLE FOR CASH GRANTS WHILE ESTIMATED NUMBER OF GRANTS EQUALS TOTAL OF ALL AMERICORPS VISTA PROJECTS, TH

THROUGH THEIR OUTREACH AND TRACKING PROGRAM AND YOUTH TRANSITION CENTER (YTC), TIDE FAMILY SERVICES WILL SERVICE AT-RISK YOUTH AGE THROUGHOUT THE STATE OF RHODE ISLAND. THE OUTREACH AND TRACKING PROGRAM IS A COMMUNITY-BASED, INTENSIVE SUPERVISION PROGRAM WITH A GOAL OF FAMILY PRESERVATION AND SCHOOL COMPLETION WITH YOUTH AGES 6 TO 18 AND FAMILIES INVOLVED WITH PROBATION. THE YTC PROGRAM IS A UNIQUE COLLABORATION BETWEEN TIDES, THE DEPARTMENT OF CHILDREN, YOUTH AND FAMILIES AND THE RHODE ISLAND TRAINING SCHOOL FOR MALE AND FEMALE YOUTH, AGED 13 TO 19. THE YTC WILL HELP YOUTH TO PREPARE FOR RELEASE FROM THE RHODE ISLAND TRAINING SCHOOL AND TO MEET THE CONDITIONS OF THEIR PROBATION, EMPHASIZING RESPONSIBILITY AND PREVENTION STRATEGIES TO AVOID RE-ENTRY INTO THE JUVENILE JUSTICE SYSTEM.

STARTALK LANGUAGE INITIATIVE

STARTALK LANGUAGE INITIATIVE

LIFE OF THE LAW

STARTALK LANGUAGE INITIATIVE

STARTALK LANGUAGE INITIATIVE

STAND ALONE COMPETITIVE JACS GRANT

TRAIN AGRICULTURAL PRODUCERS TO UTILIZE MODERN TOOLS AND EQUIPMENTALONGSIDE TECHNIQUES INFLUENCED BY TRADITIONAL NATIVE PRACTICES THATMAKE THEIR ONGOING AGRICULTURAL ACTIVITIES SUSTAINABLE.

STARTALK LANGUAGE INITIATIVE

STARTALK LANGUAGE INITIATIVE

NEXO: BILINGUAL BEHAVIORAL HEALTH SERVICES FOR CHILDREN

FUNDING FOR THE JUVENILE JUSTICE MUSIC PROGRAM WILL EXPAND THE USE OF A SOUND STUDIO, WHICH WAS FUNDED BY A BOARD MEMBER. THE ADDITIONAL FUNDS WILL BE USED TO TRAIN A CURRENT STAFF MEMBER AS A SOUND ENGINEER FOR BETTER USE OF THE EQUIPMENT AND TO MORE ADEQUATELY WORK WITH OUR YOUTH TRANSITION PROGRAM. THE TRAINING WITH A SOUND ENGINEER WILL PROVIDE MANY POSITIVE SKILLS FOR THE YOUNG ADULTS TRANSITIONING OUT OF THE RHODE ISLAND TRAINING SCHOOL.

SCALING UP: A WORKSHOP TO EXPLORE BUILDING SYSTEMIC COMMUNICATION CAPACITY FOR NEXT-GENERATION SCIENTISTS

FARM TO SCHOOL GRANT PROGRAM

TRANSFORMATION INITIATIVE RESEARCH GRANTS: DEMONSTRATION AND RELATED SMALL GRANTS

CONFERENCE: REVOLUTIONIZING TEACHER SUPPLY + DEMAND, A BEYOND100K SOLUTION LAB -THE PROJECT AIMS TO SERVE THE NATIONAL NEED TO GENERATE SOLUTIONS TO THE PROBLEM OF INEFFECTIVELY TRACKING THE TEACHER WORKFORCE. STATES MUST BE ABLE TO PREDICT AND PREPARE THE TEACHER POPULATION NEEDED TO OFFER STEM COURSES RELEVANT TO STUDENTS AND TO THE FUTURE WORKFORCE TO RESOLVE THE STEM TEACHER SHORTAGE. STATES MUST ALSO BE ABLE TO BUILD A RACIALLY DIVERSE TEACHER PIPELINE THAT REFLECTS THE DIVERSITY OF THEIR STUDENTS TO ENCOURAGE THE PARTICIPATION OF UNDERREPRESENTED MINORITY STUDENTS IN STEM FIELDS. TO ADDRESS THIS ISSUE, BEYOND100K WILL HOST A WORKSHOP IN SPRING 2024, INVITING STATE-LEVEL EDUCATION OFFICE REPRESENTATIVES FROM ALL FIFTY STATES, TO LAUNCH THE PROCESS OF DESIGNING THIS TOOL. THE DESIGN REQUIREMENTS FOR THE TOOL AND SYSTEM AND COHESION OF AN ECOSYSTEM THAT WILL LEAD EFFORTS TO TRANSFORM HOW STATES COLLABORATE TO ADDRESS AND PREVENT STEM TEACHER VACANCIES ARE THE PROPOSED OUTCOMES OF THIS WORKSHOP. THIS TOOL WILL SUPPORT STATES, DISTRICTS, AND TEACHER PREPARATION PROGRAMS TO BE ABLE TO PREDICT AND FULFILL THEIR STEM TEACHER WORKFORCE NEEDS. THIS PROJECT AT BEYOND100K INCLUDES PARTNERSHIPS WITH THE UNITED STATES DEPARTMENT OF EDUCATION AS WELL AS STATE DEPARTMENTS OF EDUCATION. PROJECT GOALS INCLUDE DETERMINING THE NECESSARY COMPONENTS OF A TEACHER PIPELINE TRACKING AND PROJECTION TOOL AND SYSTEM AND CONNECTING LOCAL AND NATIONAL K-12 STEM ECOSYSTEM PARTNERS TO RESOURCES FOR TRACKING AND DOCUMENTING K-12 STEM TEACHER PIPELINE CHANGES. THE CONFERENCE WILL SHARE BRIGHT SPOTS FROM OTHER SECTORS, HIGHLIGHT EXISTING MODELS FROM WITHIN K-12, AND DETERMINE THE DESIGN REQUIREMENTS FOR SYSTEMS USED FOR TRACKING K-12 STEM TEACHER RECRUITMENT WITH A FOCUS ON PREPARING AND RETAINING TEACHERS WHO REPRESENT THE RACIAL AND ETHNIC DIVERSITY OF THEIR STUDENTS. RESEARCH QUESTIONS INCLUDE: 1) WHAT SUCCESSES AND CHALLENGES ARE STATES, DISTRICTS, AND OTHERS FACING IN UNDERSTANDING, PROJECTING, AND PLANNING FOR TEACHER VACANCIES? 2) HOW CAN TECHNOLOGY, AI, EXISTING PROCESSES AND DATA, AND HUMAN-CENTERED DESIGN PRINCIPLES BE USED TO OUTLINE THE SPECIFICATIONS FOR A TOOL FOR UNDERSTANDING, PROJECTING, AND PLANNING FOR TEACHER VACANCIES THAT MEET THE DIVERSE NEEDS OF MANY STATES AND SCHOOL DISTRICTS? THIS TOOL WOULD ULTIMATELY ENABLE STATES AND LOCALITIES TO MANAGE THEIR HUMAN RESOURCE NEEDS AND DEVELOP TARGETED, DATA-DRIVEN STRATEGIES TO RESPOND TO THEIR TEACHER WORKFORCE NEEDS AND VACANCIES AND UNLOCK THE POTENTIAL FOR POWERFUL DATA AND LEARNINGS ABOUT THE STEM-TEACHER PIPELINE. CONFERENCE OUTCOMES AND PARTICIPANT EXPERIENCE DATA WILL BE COLLECTED IN A NARRATIVE REPORT AND MADE AVAILABLE TO THE PUBLIC ON THE PROJECT'S WEBSITE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

COMMUNITY FACILITIES - ECONOMIC IMPACT INITIATIVE GRANTS

FARM TO SCHOOL GRANT PROGRAM

ONE GENERATION PROPOSES A SIMPLIFIED BFRDP PROJECT TO BUILD ITS CAPACITY TO EDUCATE, MENTOR, AND PROVIDE TECHNICAL ASSISTANCE TO BEGINNING INDIGENOUS FARMERS AND RANCHERS IN NEW MEXICO AND THE SOUTHWEST. THIS PROJECT ADDRESSES CHALLENGES INCLUDING DISCONNECTED INDIGENOUS AGRICULTURAL TRADITIONS AND KNOWLEDGE OF INDIGENOUS FARMING PRACTICES, A LACK OF PROFITABILITY OF INDIGENOUS FARMS/RANCHES, AND LACK OF TRAININGS SPECIFIC TO THE NEEDS OF FARMERS IN THE SOUTHWEST. OUTCOMES INCLUDE A COMPREHENSIVE SET OF CURRICULA WITH INDIGENOUS LANGUAGE, PRACTICES, AND CULTURAL CONCEPTS INCORPORATED, TO IMPROVE PROSPERITY AND STRENGTHEN FOOD, CULTURAL, AND LAND SOVEREIGNTY FOR INDIGENOUS PEOPLES.OBJECTIVES: HOST SIX COMMUNITY CONVENINGS; FORMALIZE AN ADVISORY COMMITTEE COMPOSED OF INDIGENOUS AGRICULTURAL AND LANGUAGE EXPERTS, BEGINNING FARMERS AND RANCHERS, AND COMMUNITY PARTNERS; CATALOGUE EXISTING LESSONS, TRAINING MODULES, AND/OR ESTABLISHED CURRICULUM IN KEY LEARNING STRANDS; INCORPORATE INTERGENERATIONAL INDIGENOUS KNOWLEDGE AND PRACTICES INTO THE CORE CURRICULUM AND LEARNING ACTIVITIES; TEST DELIVERY OF CURRICULUM; AND CREATE AN ACTION PLAN TO DEVELOP/LAUNCH A FELLOWSHIP PROGRAM.PARTNERS: NATIVE AMERICAN COMMUNITY ACADEMY AND THE UNIVERSITY OF NEW MEXICO COMMUNITY ENGAGEMENT CENTER.USDA PRIORITIES: (1) LEAD AGENCY HAS NEVER RECEIVED USDA FUNDING; (2) LEAD AGENCY IS A NONGOVERNMENTAL AND COMMUNITY-BASED ORGANIZATION; AND (3) 100% OF FUNDS WILL ADDRESS THE NEEDS OF SOCIALLY DISADVANTAGED OR LIMITED RESOURCE BEGINNING FARMERS OR RANCHERS. APPROXIMATELY 62% OF FEDERAL FUNDS ALLOCATED WILL SUPPORT NONGOVERNMENTAL AND COMMUNITY-BASED ORGANIZATIONS, PLUS AN ADDITIONAL 20% OF FEDERAL FUNDS ALLOCATED WILL PROVIDE STIPENDS TO BEGINNING FARMERS AND RANCHERS FOR CONSULTATION AND PARTICIPATION IN PILOT TESTING CURRICULUM. THE REMAINING 18% FUNDS CONSULTANT EVALUATION.

FARM TO SCHOOL GRANT PROGRAM

FARM TO SCHOOL GRANT PROGRAM

RESTORE UPPER NEWPORT BAY AREA

ONE GENERATION WILL CONDUCT A REGIONAL FOOD SYSTEM ASSESSMENT AND PLANNING PROJECT IN CENTRAL AND NORTHWESTERN NEW MEXICO. THE FOCUS GEOGRAPHIES OF SAN JUAN AND SANDOVAL COUNTIES ARE CULTIVATED BY PUEBLO, NAVAJO/DINÉ, AND UTE TRIBES. MORE THAN ONE-FOURTH OF THE POPULATION IS AMERICAN INDIAN OR ALASKA NATIVE ALONE (COMPARED TO 1.1% OF THE U.S.). THE MAJORITY OF INDIGENOUS PRODUCERS IN THE REGION IDENTIFY FARMING AS A PRIMARY INCOME SOURCE, BUT 98% OF INDIGENOUS OPERATIONS IN NEW MEXICO HAVE ANNUAL SALES UNDER $25,000. FURTHERMORE, JUST 6% OF THE PRODUCERS IN FOCUS COUNTIES SOLD DIRECTLY TO CONSUMERS; HOWEVER, THE DISPARITIES BY RACE ARE STARKER WITH 3% OF AI/AN PRODUCERS VERSUS 11% OF WHITE PRODUCERS. THIS SPEAKS TO A BROADER ISSUE: NEW MEXICO IMPORTS 90% OF ITS FOOD AND EXPORTS 97% OF AGRICULTURAL PRODUCTS. FINALLY, A SIGNIFICANT MAJORITY OF THIS REGION QUALIFIES AS LOW-INCOME AND/OR HAS LIMITED ACCESS TO FRESH, HEALTHY, AND AFFORDABLE PRODUCE AND IT HAS BEEN FIRMLY ESTABLISHEDTHAT LOW-INCOME FAMILIES ARE MORE LIKELY TO EXPERIENCE FOOD INSECURITY AND POORER CHRONIC HEALTH CONDITIONS AS A RESULT OF DIET. NATIVE AMERICANS IN NEW MEXICO ARE 300% MORE LIKELY THAN NON-HISPANIC WHITES IN NEW MEXICO TO HAVE DIABETES AND 172% MORE LIKELY TO EXPERIENCE OBESITY. A FRACTURED FOOD SYSTEM WITH FEW ORGANIZED COLLECTIVE RESOURCES SERVES THIS REGION'S POPULATION OF ABOUT 270,000.ONE GENERATION WILL PERFORM A COMMUNITY FOOD SECURITY ASSESSMENT, WITH A FOCUS ON UNDERSTANDING BARRIERS TO FOOD ACCESS AMONGST LOW-INCOME AND INDIGENOUS POPULATIONS AND EXISTING/POTENTIAL FOOD SYSTEM RESOURCES. WITH PARTNERS INCLUDING THE UNITED WAY OF CENTRAL NEW MEXICO, INDIAN PUEBLO CULTURAL CENTER, NOTAH BEGAY III FOUNDATION, AND THE NEW MEXICO FARMERS MARKET ASSOCIATION, AS WELL AS LOW-INCOME AND INDIGENOUS PARTICIPANTS, ONE GENERATION WILL FORM A STATEWIDE INDIGENOUS FOOD COUNCIL AND CO-CREATE LONG-TERM SUSTAINABLE AND COMPREHENSIVE FOOD SYSTEMS INTERVENTIONS TO COMBAT FOOD INSECURITY, MONITOR RESPONSIVENESS OF SERVICES, AND ADDRESS UNDERLYING FACTORS RELATED TO HUNGER AND NUTRITION. PARTNERS WILL ASSESS AND PLAN PROGRAMMING THAT ADVANCES SUSTAINABLE, INDIGENOUS FARMING PRACTICES AND ACCESS TO FOOD BY LOW-INCOME COMMUNITY MEMBERS. THIS WILL INCLUDE A PRODUCER FOOD HUB IN SANDOVAL COUNTY AND EVALUATION OF POTENTIAL ADDITIONAL MODELS SUCH AS A MULTI-FARMER CSA, FARMER COOPERATIVE, AND NATIVE AMERICAN FARMERS MARKET.BENEFITS INCLUDE: (1) FOOD ACCESS AND SECURITY CHALLENGES ARE IDENTIFIED; (2) NEW AND EXISTING SECTOR LINKAGES THAT SUPPORT A COMPREHENSIVE RESPONSE TO FOOD SECURITY AND FOOD SOVEREIGNTY NEEDS ARE DOCUMENTED; (3) A COMMUNITY-DEFINED AND COMMUNITY-LED VISION AND VALUES STATEMENT RELATED TO FOOD SYSTEMS AND SOVEREIGNTY IS CREATED AND USED TO IDENTIFY AND ACT ON PRIORITIES; AND (4) THE COMMUNITY HAS A FEASIBILITY ASSESSMENT AND PLANS FOR COMMUNITY FOOD PROJECTS THAT SUPPORT HEALTHY AND SUSTAINABLE FOOD SYSTEMS, FOOD SECURITY AND NUTRITION, AND SUCCESS OF INDIGENOUS AGRICULTURAL PRODUCERS. ULTIMATELY, ONE GENERATION WILL ADVANCE ITS WORK IN BRINGING TOGETHER COMMUNITY STAKEHOLDERS WITHIN WHOLE FOOD SYSTEMS TO ASSESS OUR COMMUNITIES' STRENGTHS, ESTABLISH LINKAGES, AND CREATE SUSTAINABLE FOOD SYSTEMS THAT IMPROVE THE SELF-RELIANCE OF COMMUNITY MEMBERS ON THEIR OWN FOOD NEEDS IN NORTHWEST NEW MEXICO.

12TH INTERNATIONAL SYMPOSIUM OF IMMUNOBIOLOGY INFECTIOUS AGENTS: IMMUNOBIOLOGY COUNTERMEASURES

THIS GRANT SUPPORTS THE COSTS INCURRED TO IMPLEMENT MEASURES TO RESPOND TO THE NOVEL CORONAVIRUS 2019 (COVID-19), WHICH MAY INCLUDE WORKPLACE SAFETY, MARKET PIVOTS, RETROFITTING FACILITIES, TRANSPORTATION, WORKER HOUSING, AND MEDICAL EXPENSES. IT PROVIDES NEEDED RELIEF TO THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS FOR THEIR COSTS INCURRED BETWEEN JANUARY 27, 2020, THE DATE UPON WHICH THE PUBLIC HEALTH EMERGENCY WAS DECLARED BY THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICE (HHS) UNDER SECTION 319 OF THE PUBLIC HEALTH SERVICE ACT, AND DECEMBER 31, 2021. BENEFICIARIES INCLUDE THE EMPLOYEES OF THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS.

FARM TO SCHOOL GRANT PROGRAM

FARM TO SCHOOL GRANT PROGRAM

THE LOCAL FOOD ALLIANCE-CONNECTING SMALL LOCAL FARMERS AND UNDERSERVED COMMUNITIES IN WASH