Georgia Tech Research Corporation

NSF ENGINEERING RESEARCH CENTER FOR CELL MANUFACTURING TECHNOLOGIES (CMAT)

COMBUSTION MODEL DEVELOPMENT AND EVALUATION

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH IN SUPPORT OF BTO IN THE AMOUNT OF 6,816,989 ON CONTRACT HR0011-19-2-0008.

CENTER FOR UNDERSTANDING AND CONTROL OF ACID GAS-INDUCED EVOLUTION OF MATERIALS FOR ENERGY (UNCAGE-ME)

GEORGIA TECH RESEARCH CORPORATION; ''CONSORTIUM FOR ENABLING TECHNOLOGIES AND INNOVATION (ETI);'' *NEW AWARD

CATEGORY I: NEXUS: A CONFLUENCE OF HIGH-PERFORMANCE AI AND SCIENTIFIC COMPUTING WITH SEAMLESS SCALING FROM LOCAL TO NATIONAL RESOURCES -SCIENCE AND ENGINEERING RESEARCH HAS EVOLVED TO INCREASINGLY RELY ON DATA-INTENSIVE AND ARTIFICIAL INTELLIGENCE (AI) DRIVEN METHODOLOGIES. THIS, IN TURN, HAS LED TO MORE COMPLEX WORKFLOWS THAT INVOLVE HARDWARE AND SOFTWARE RESOURCES AT DIFFERENT SCALES AND OPERATING IN DIFFERENT ENVIRONMENTS. THESE GROWING COMPLEXITIES NECESSITATE A FLEXIBLE AND HETEROGENEOUS HARDWARE AND SOFTWARE INFRASTRUCTURE THAT TRANSFORMS EXISTING, DISJOINTED WORKFLOWS VIA A SEAMLESS AND MORE PRODUCTIVE COMPUTATIONAL ENVIRONMENT THAT IS EASIER AND MORE INTUITIVE TO USE. NEXUS PROVIDES SUCH A CRITICAL NATIONAL RESOURCE TO THE SCIENCE AND ENGINEERING RESEARCH COMMUNITY; IT SERVES BOTH AS A STANDALONE PLATFORM AND AS A GATEWAY TO EFFECTIVELY UTILIZING OTHER NATIONAL RESOURCES, SIGNIFICANTLY ACCELERATING AI-DRIVEN SCIENTIFIC DISCOVERY. NEXUS WILL ADVANCE AMERICAN LEADERSHIP IN ARTIFICIAL INTELLIGENCE AND ADVANTAGE U.S.-BASED RESEARCH AND INDUSTRY ENTERPRISES IN DIVERSE AREAS OF SCIENCE AND ENGINEERING, ENABLING BREAKTHROUGH DISCOVERIES, INCREASING ECONOMIC COMPETITIVENESS, AND ADVANCING HUMAN HEALTH. NEXUS IS A NEXT-GENERATION, NATIONAL-SCALE COMPUTATIONAL RESOURCE INTEGRATING CUTTING-EDGE HETEROGENEOUS HARDWARE, AI-ACCELERATED COMPUTING, AND ADVANCED SOFTWARE SERVICES TO UNIFY SCIENTIFIC AND ENGINEERING RESEARCH WORKFLOWS. LED BY THE GEORGIA INSTITUTE OF TECHNOLOGY IN COLLABORATION WITH THE NATIONAL CENTER FOR SUPERCOMPUTING APPLICATIONS (NCSA) AT THE UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN, NEXUS PROVIDES A SEAMLESS AND SCALABLE COMPUTATIONAL ENVIRONMENT THAT BRIDGES LOCAL AND NATIONAL RESOURCES. THE NEXUS COMPUTATIONAL INFRASTRUCTURE INCORPORATES SUBSTANTIAL CPU AND GPU RESOURCES THAT DELIVER 14.5 PETAFLOPS OF PEAK DOUBLE-PRECISION CALCULATIONS AND OVER 400 PETAFLOPS OF PEAK AI-FOCUSED, REDUCED-PRECISION CALCULATIONS. THIS COMPUTING CAPABILITY IS AUGMENTED BY HIGH-SPEED MEMORY, A 10-PETABYTE ALL-FLASH FILE SYSTEM, AND A NEXT-GENERATION HIGH-SPEED NETWORK BASED ON INFINIBAND AND SOCKET DIRECT TECHNOLOGIES. THIS INFRASTRUCTURE IS INTEGRATED WITH A NOVEL SOFTWARE PLATFORM INCORPORATING THE NEXUS COMPUTING INFRASTRUCTURE WITHIN RESEARCHERS? LOCAL ENVIRONMENTS, ALLOWING THEM TO HARNESS POWERFUL COMPUTATIONAL CAPABILITIES WITHOUT DISRUPTING THEIR WORKFLOWS. THE NEXUS PLATFORM WILL ALSO FACILITATE FEDERATED RESOURCE SHARING, ENABLING INTEROPERABILITY WITH NATIONAL CYBERINFRASTRUCTURE ASSETS, INCLUDING THE NSF-FUNDED DELTA AND DELTAAI SYSTEMS AT NCSA. FINALLY, IT SUPPORTS MULTI-SCALE, HETEROGENEOUS COMPUTING, GIVING RESEARCHERS ACCESS TO DIVERSE COMPUTATIONAL ARCHITECTURES THROUGH A UNIFIED INTERFACE, AN ESSENTIAL CAPABILITY FOR AI-DRIVEN RESEARCH AND COMPUTATIONAL SCIENCES THAT REQUIRE TAILORED, SCALABLE COMPUTING POWER. REGIONAL ENGAGEMENTS, TRAINING WORKSHOPS, STUDENT AND FACULTY DEVELOPMENT PROGRAMS, AND COLLABORATIVE RESEARCH PARTNERSHIPS WILL BE DEVELOPED TO LEVERAGE INNOVATIVE FEATURES OF THE NEXUS RESOURCE FOR SUPPORTING AND EXPANDING THE NATION?S GLOBALLY COMPETITIVE STEM WORKFORCE EQUIPPED WITH ESSENTIAL AI AND HPC SKILLS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

CCI: CENTER FOR CHEMICAL EVOLUTION

AI INSTITUTE FOR COLLABORATIVE ASSISTANCE AND RESPONSIVE INTERACTION FOR NETWORKED GROUPS (AI-CARING)

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

CENTER FOR CHEMICAL INNOVATION: CENTER FOR CHEMICAL EVOLUTION

AI INSTITUTE FOR ADVANCES IN OPTIMIZATION

AI INSTITUTE FOR ADULT LEARNING AND ONLINE EDUCATION (ALOE) -BASED ON DECADES OF STUDY OF HUMAN LEARNING, IT IS KNOWN THAT MUCH OF HUMAN LEARNING IS MEDIATED BY OTHERS (GUIDED BY TEACHERS), IS A SOCIAL/COLLABORATIVE PROCESS, AND USES A RANGE OF COGNITIVE STRATEGIES. CHILDHOOD AND ADULT LEARNING LIE ON A SPECTRUM OF COGNITIVE ABILITIES. TWO CHARACTERISTICS THAT DISTINGUISH ADULT LEARNING FROM CHILDHOOD LEARNING ARE FIRST, WHILE MUCH OF K-12 LEARNING PERTAINS TO CLOSED, WELL-DEFINED PROBLEMS WITH CLEAR ANSWERS, ADULT LEARNING - ESPECIALLY ADULT LEARNING IN THE WORKPLACE - OFTEN ADDRESSES OPEN-ENDED, ILL-DEFINED PROBLEMS THAT MAY HAVE NO CLEAR ANSWER OR THAT MAY ADMIT MULTIPLE ANSWERS. SECOND, WHILE MOST K-12 LEARNING IS GENERAL-PURPOSE AND TEACHER-GUIDED, ADULT LEARNING (ESPECIALLY IN THE WORKPLACE) IS TASK-SPECIFIC AND SELF-DIRECTED, HENCE THE PROLIFERATION OF EDUCATIONAL RESOURCES (OFTEN ONLINE) IN SUPPORT OF ADULT LEARNING. GEORGIA RESEARCH ALLIANCE (GRA) WILL ESTABLISH A NATIONAL ARTIFICIAL INTELLIGENCE INSTITUTE TITLED ?NSF AI INSTITUTE FOR ADULT LEARNING AND ONLINE EDUCATION (ALOE)?, THE GOAL OF WHICH IS TO MAKE EDUCATION MORE EQUITABLE THROUGH ENHANCED AVAILABILITY, GREATER AFFORDABILITY, AND ENHANCED POTENTIAL FOR SUCCESS. ENHANCED AVAILABILITY IS TO BE ACHIEVED THROUGH THE USE OF ONLINE EDUCATIONAL RESOURCES FOR BLENDED LEARNING; GREATER AFFORDABILITY IS TO BE ACCOMPLISHED THROUGH LOW-COST VIRTUAL TEACHING ASSISTANTS THAT AMPLIFY TEACHERS? REACH, WHILE ENHANCED POTENTIAL FOR SUCCESS IS TO BE ACHIEVED THROUGH COGNITIVE AND SOCIAL SUPPORT PROVIDED BY VIRTUAL TEACHING ASSISTANTS. THE ARTIFICIAL INTELLIGENCE (AI) PROJECT AIMS TO SERVE THE NATIONAL INTEREST THROUGH THE DEVELOPMENT OF TRANSFORMATIVE AI-DRIVEN MODELS OF ONLINE ADULT LEARNING THAT BLEND HIGHER AND CONTINUING EDUCATION TO RADICALLY IMPROVE HUMAN LEARNING. A COMPREHENSIVE AND WELL-ORGANIZED PLAN IS PROPOSED THAT USES AI SIMULTANEOUSLY TO TRANSFORM ONLINE ADULT LEARNING AND TO DRIVE FOUNDATIONAL RESEARCH IN AI. GRA IS A 30-YEAR-OLD PRIVATE, NONPROFIT CORPORATION THAT COLLABORATES WITH STATE GOVERNMENT, BUSINESS COMMUNITY, AND UNIVERSITY SYSTEM TO ADVANCE SCIENCE AND TECHNOLOGY THAT GENERATES DIRECT ECONOMIC BENEFITS. THE ALOE AI INSTITUTE INVOLVES A LARGE INTERDISCIPLINARY RESEARCH TEAM THAT INCLUDES TWO NON-PROFIT ORGANIZATIONS (GEORGIA RESEARCH ALLIANCE, IMS GLOBAL), THREE INDUSTRIAL COMPANIES (BOEING, IBM, WILEY) AND SEVEN EDUCATIONAL INSTITUTIONS (ARIZONA STATE UNIVERSITY, DREXEL UNIVERSITY, GEORGIA INSTITUTE OF TECHNOLOGY, GEORGIA STATE UNIVERSITY, HARVARD UNIVERSITY, TECHNICAL COLLEGE SYSTEM OF GEORGIA, UNIVERSITY OF NORTH CAROLINA AT GREENSBORO). ADDITIONALLY, ACCENTURE, THE MULTINATIONAL CONSULTING COMPANY, IS PARTNERING WITH NSF TO PROVIDE FUNDING FOR THE INSTITUTE. OVERALL, THE GOALS OF THE PROJECT ARE CONSISTENT WITH NSF AI INSTITUTES? VISION TO ADVANCE FOUNDATIONAL RESEARCH, CONDUCT USE-INSPIRED RESEARCH, AND GROW THE NEXT GENERATION OF DIVERSE TALENT BY LEVERAGING MULTIPLE ORGANIZATIONS. WITH REGARD TO FOUNDATIONAL RESEARCH, MAJOR SYNERGISTIC CONTRIBUTIONS ARE ANTICIPATED IN FOUR AREAS:(I) COGNITIVELY-GROUNDED AI (AI VIRTUAL ASSISTANTS THAT ARE GROUNDED IN COGNITIVE THEORIES OF ADULT LEARNING SUCH AS ACTIVE LEARNING); (II) AI-BASED PERSONALIZATION AT SCALE (COLLECTION OF LEARNING DATA FROM MILLIONS OF ADULT LEARNERS AND DEVELOPMENT OF NOVEL MACHINE LEARNING AND NATURAL LANGUAGE PROCESSING TECHNIQUES FOR ANALYZING THE DATA); (III) HUMAN-AI COLLABORATION: DEVELOPMENT OF NOVEL TECHNIQUES FOR INTERACTIVE VISUALIZATION THAT ENABLES TEACHERS AND LEARNERS TO BUILD A MUTUAL THEORY OF MIND; (IV) RESPONSIBLE AI: DISCOVERY OF PRINCIPLES FOR DESIGNING SOCIOTECHNICAL SYSTEMS FOR ONLINE ADULT EDUCATION IN WHICH AI AGENTS WORK ETHICALLY TO BENEFIT HUMANS. WITH REGARD TO USE-INSPIRED RESEARCH, RESPONSIBLE FUNDAMENTAL AI RESEARCH GROUNDED IN THEORIES OF HUMAN COGNITION AND LEARNING WILL BE CONDUCTED. AT LEAST TWO DISTINCT THRUSTS ARE IN PLACE: (I) DEVELOPMENT OF AI TEACHING AND LEARNING ASSISTANTS THAT ENHANCE COGNITIVE, TEACHER AND SOCIAL PRESENCE IN ONLINE ADULT LEARNING TO HELP MAKE IT EFFICIENT AND EFFECTIVE; (II) LEARNING ANALYTICS FOR PERSONALIZATION OF LARGE-SCALE ONLINE LEARNING FOR ADULT EDUCATION. THE METHODOLOGY EMPLOYED, LEARNING ENGINEERING, IS AN ITERATIVE DESIGN APPROACH THAT BRINGS THE RIGOR OF ENGINEERING TO THE DISCIPLINE OF EDUCATION. BEGINNING WITH HUMAN-CENTERED DESIGN OF AI TECHNOLOGIES, WHERE THE HUMAN COULD BE A LEARNER, A TEACHER, OR A DIFFERENT STAKEHOLDER IN THE LEARNING PROCESS, THE PROCESS CONTINUES WITH THE DEPLOYMENT OF AI TECHNOLOGIES AND COLLECTION AND ANALYSIS OF LARGE-SCALE DATA ABOUT LEARNERS AND LEARNING. THE PROCESS THEN CONTINUES TO THE ASSESSMENT OF LEARNING BEHAVIORS AND OUTCOMES FOLLOWED BY THE REFINEMENT OF HUMAN-CENTERED AI TECHNOLOGIES. A DETAILED PLAN IS PROVIDED FOR ASSESSMENT OF IMPACT ON BOTH LEARNING AND TEACHING THROUGH A MIXED METHODS APPROACH. RANDOMIZED CONTROLLED TRIALS WILL BE USED TO EVALUATE HOW THE USE OF AI TECHNOLOGIES FACILITATES AND IMPACTS LEARNING. QUASI-EXPERIMENTAL STUDIES WILL BE CARRIED OUT TO COMPARE LEARNING EFFECTIVENESS AND EFFICIENCY OF ONLINE VERSUS IN-PERSON CLASSES. A PLAN FOR EVALUATION OF THE PROCESS OF PROJECT EXECUTION IS TO BE OVERSEEN BY AN EXPERIENCED EVALUATOR WHO WILL EMPLOY A VALUES-ENGAGED, EDUCATIVE APPROACH WHICH SEEKS TO CAPTURE THE VIEWPOINTS, INTERESTS, AND VALUES OF ALL STAKEHOLDERS, INCLUDING THOSE OFTEN UNDERREPRESENTED IN THE EVALUATION CONTEXT. THE NATIONAL ARTIFICIAL INTELLIGENCE INSTITUTES PROGRAM IS A MULTI-AGENCY EFFORT TO ESTABLISH INSTITUTE-SCALE AI RESEARCH WITH THE POTENTIAL FOR LONG-TERM PAYOFFS IN AI. IN ADDITION TO ADVANCING FOUNDATIONAL RESEARCH AND CONDUCTING USE-INSPIRED RESEARCH, THE PROGRAM SUPPORTS EFFORTS TO GROW THE NEXT GENERATION OF AI TALENT, ENHANCE MULTIDISCIPLINARY AI RESEARCH, LEVERAGE MULTIPLE ORGANIZATIONS AND PROVIDE A NEXUS POINT FOR COLLABORATIVE EFFORTS IN AI RESEARCH AND DEVELOPMENT. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

GEORGIA TECH RESEARCH CORPORATION

THE KEY OBJECTIVE OF THE JANUS IS TO DEVELOP THE CAPABILITY TO TEST THE ADVANCED HIGH-POWER ELECTRIC PROPULSION (EP) TECHNOLOGIES THAT ARE CRITICAL TO NASA S VISION FOR FUTURE HUMAN EXPLORATION.

CONSORTIUM FOR ENABLING TECHNOLOGIES AND INNOVATION 2.0 IS TO DIRECT THE MULTIDISCIPLINARY RESEARCH AND INNOVATION THAT ENABLE THE TECHNOLOGIES THAT SUPPORT THE NNSA DNN R&D, TO TRAIN THE NEXT-GENERATION OF RESEARCHERS, AND TO BRIDGE THE GAP BETWEEN THE UNIVERSITY BASIC RESEARCH AND NATIONAL LABORATORIES’ MISSION-SPECIFIC APPLICATIONS.

GEORGIA MANUFACTURING EXTENSION PARTNERSHIP

GEORGIA TECH RESEARCH CORPORATION

MID-SCALE RI-1 (M1:IP): ATMOSPHERIC SCIENCE AND CHEMISTRY MEASUREMENT NETWORK (ASCENT)

KEENELAND: NATIONAL INSTITUTE FOR EXPERIMENTAL COMPUTING

PILOT-SCALE LABORATORY FOR CARBON-NEUTRAL ENERGY SOLUTIONS.

NANO-TAILORED ADVANCED CARBON FIBERS

INFLUENZA VACCINATION USING A MICRONEEDLE PATCH

GRADUATE RESEARCH FELLOWSHIP PROGRAM

IN THIS 5-YEAR RESEARCH PROGRAM, THE PRINCIPAL GOALS OF THE TC-COE AND THE PROPOSED SYNTHETIC, PHYSICAL, AND SPECTROSCOPIC STUDIES ARE: (1) TO DEFINE THE STRUCTURE, BONDING, AND REACTIVITY OF PLUTONIUM HYDRIDE COMPLEXES, AND (2) TO DISENTANGLE THE EFFECTS OF MEDIA, AUTORADIOLYTIC PROCESSES, AND COORDINATION CHEMISTRY IN CONTROLLING THE KINETICS AND THERMOCHEMISTRY OF AMERICIUM REDOX REACTIONS SUPPORTED BY THE DEVELOPMENT OF NOVEL DETECTOR AND SPECTROSCOPIC INSTRUMENTATION. THESE GOALS SEEK TO DEFINE THE FUNDAMENTAL CRITERIA NECESSARY TO ADDRESS LONG-STANDING CHALLENGES IN UNDERSTANDING AND PREDICTING THE BEHAVIOR OF PUHX AND IN PREPARING PURE AMERICIUM FROM A VARIETY OF FEEDSTOCKS. THESE TWO RESEARCH GOALS ARE HIGHLY SYNERGISTIC (FIG. 1): THE REQUISITE INFRASTRUCTURE AS WELL AS METHODOLOGIES ARE RELATED AND CAN ONLY BE ADDRESSED BY THE PROPOSED, TIGHTLY-KNIT MULTIDISCIPLINARY TEAM.

MRSEC: THE GEORGIA TECH LABORATORY FOR NEW ELECTRONIC MATERIALS

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) -THE NATIONAL SCIENCE FOUNDATION (NSF) GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) IS A HIGHLY COMPETITIVE FEDERAL FELLOWSHIP PROGRAM. GRFP HELPS ENSURE THE QUALITY, VITALITY, AND STRENGTH OF THE SCIENTIFIC AND ENGINEERING WORKFORCE OF THE UNITED STATES. THE PROGRAM RECOGNIZES AND SUPPORTS OUTSTANDING GRADUATE STUDENTS WHO ARE PURSUING RESEARCH-BASED MASTER'S AND DOCTORAL DEGREES IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM), INCLUDING STEM EDUCATION. GRFP PROVIDES THREE YEARS OF FINANCIAL SUPPORT FOR THE GRADUATE EDUCATION OF INDIVIDUALS WHO HAVE DEMONSTRATED THEIR POTENTIAL FOR SIGNIFICANT ACHIEVEMENTS IN STEM. THIS AWARD SUPPORTS THE NSF GRADUATE FELLOWS PURSUING GRADUATE EDUCATION AT THIS AWARDEE INSTITUTION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

NSF I-CORPS HUB (TRACK 1): SOUTHEAST REGION -THE BROADER IMPACT/COMMERCIAL POTENTIAL OF THIS I-CORPS HUBS PROJECT IS THE DEVELOPMENT OF A TRANSFORMATIVE ENTREPRENEURIAL ECOSYSTEM THAT ENHANCES THE NATION'S ECONOMIC AND INDUSTRIAL COMPETITIVENESS THROUGH FOSTERING ENTREPRENEURSHIP AND DEEP TECHNOLOGY WORKFORCE DEVELOPMENT. SPANNING FOUR SOUTHERN STATES WITH SIGNIFICANT DEMOGRAPHIC DIVERSITY, THE HUB ADDRESSES REGIONAL INEQUITIES IN ACCESS TO CAPITAL, EXPERIENCED ENTREPRENEURS, MENTORS, AND ADVISORS FOR DEEP TECHNOLOGY RESEARCHERS. BY LEVERAGING COLLECTIVE STRENGTHS OF PARTNER INSTITUTIONS WITH EXTENSIVE BACKGROUNDS IN RESEARCH, ENTREPRENEURSHIP, AND INNOVATION, THE PROJECT AIMS TO CATALYZE THE ECOSYSTEM THROUGH MITIGATING TECHNOLOGICAL, EXPERTISE, AND CAPITAL DISPARITIES. THE HUB WILL DEPLOY A REGIONAL I-CORPS INFRASTRUCTURE WITH FULL-TIME ACCESS TO ENTREPRENEURIAL TRAINING AT SCALE, ASSISTING RESEARCHERS IN APPLYING CUSTOMER DISCOVERY PRINCIPLES TO TECHNOLOGY TRANSLATION. THIS PROJECT SERVES THE NATIONAL INTEREST BY PROMOTING INCREASED PARTICIPATION IN NATIONAL I-CORPS PROGRAMS THROUGHOUT THE REGION, CULMINATING IN AN ECOSYSTEM THAT IS DIVERSE, INCLUSIVE, AND REPRESENTATIVE OF THE REGION'S POPULATION. THE ANTICIPATED OUTCOMES INCLUDE A COMMERCIALIZATION ROADMAP WITH ENHANCED ACADEMIA-INDUSTRY PARTNERSHIPS, EQUITABLE ACCESS TO OPPORTUNITIES, AND A SUSTAINABLE INCREASE IN DIVERSITY ACROSS THE SOUTH'S INNOVATION LANDSCAPE. BY FOCUSING ON INCREASING ENGAGEMENT WITH THE SOUTHERN COMMUNITY IN TERMS OF STARTUPS AND TECHNOLOGY COMMERCIALIZATION, THE PROJECT SEEKS TO INCREASE INTEREST IN SCIENCE, TECHNOLOGY, ENGINEERING AND MATH (STEM) FIELDS, ESPECIALLY AMONG UNDERREPRESENTED GROUPS. THIS I-CORPS HUBS PROJECT IS BASED ON THE DEVELOPMENT OF A COMPREHENSIVE REGIONAL INNOVATION NETWORK THAT COMBINES THE STRENGTHS OF DIVERSE ACADEMIC INSTITUTIONS, INCLUDING HISPANIC SERVING INSTITUTIONS AND HISTORICALLY BLACK COLLEGES AND UNIVERSITIES. THE PROJECT'S GOAL IS TO CREATE A SCALABLE MODEL FOR TRANSLATING RESEARCH INTO COMMERCIAL VENTURES WITH SOCIETAL BENEFITS, INCLUDING EQUITABLE OPPORTUNITIES FOR HISTORICALLY UNDERSERVED ENTREPRENEURS. THE APPROACH INVOLVES INTEGRATING BEST PRACTICES FROM EXISTING I-CORPS HUBS PROGRAMS AND DEVELOPING TAILORED INITIATIVES FOR UNDERREPRESENTED GROUPS. KEY METHODS INCLUDE COLLABORATIVE RESEARCH, COMMERCIALIZATION ACTIVITIES, AND SPECIALIZED TRAINING PROGRAMS. THE PROJECT WILL ACTIVELY MONITOR SUCCESS METRICS FOR ALL HUB ACTIVITIES. THIS APPROACH EXTENDS BEYOND TRADITIONAL INNOVATION SUPPORT, INCORPORATING RESEARCH TO UNDERSTAND THE IMPACT OF DIFFERING ENVIRONMENTS ON PARTICIPATION. THE PROJECT AIMS TO MAKE SIGNIFICANT CONTRIBUTIONS TO ENTREPRENEURSHIP, INNOVATION POLICY, AND REGIONAL ECONOMIC DEVELOPMENT. THE GOAL IS TO POSITIVELY IMPACT THE REGION?S ECONOMY FROM THE ESTABLISHMENT OF NEW BUSINESSES AND COMMERCIALIZATION OF NEW PRODUCTS AND SERVICES THAT HAVE BENEFITTED FROM THE HUB?S I-CORPS TRAINING. THE IMPERATIVE TO DIVERSIFY THE REGION'S ECONOMIC BASE SERVES AS A STRONG MOTIVATOR, POTENTIALLY INCREASING INTEREST IN SCIENCE, TECHNOLOGY, ENGINEERING AND MATH (STEM) FIELDS AND YIELDING EQUITABLE ACCESS TO OPPORTUNITIES ACROSS THE SOUTH'S INNOVATION ECOSYSTEM. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

IMMOBILIZED MOLECULAR CATALYSTS FROM BASIC DESIGN PRINCIPLES TO CASCADE REACTIONS

VERTICAL LIFT RESEARCH CENTER OF EXCELLENCE

SYNAPTIC FUNCTION: EFFECTS OF THE NERVE INJURY, REPAIR, AND ALTERED ACTIVITY

VERTICAL LIFT RESEARCH CENTER OF EXCELLENCE - GA TECH

NNCI: SOUTHEASTERN NANOTECHNOLOGY INFRASTRUCTURE CORRIDOR (SENIC)

NOVEL CENTRIFUGAL LVAD WITH WIRELESS POWER TRANSFER AND ANTITHROMBOTIC SLIC COATING

"AIR FORCE CENTER OF EXCELLENCE ON BIO-NANO-ENABLED INORGANIC/ORGANIC NANOSTRUCTURES AND IMPROVED COGNITION (BIONIC)"

INFORMATICS-DRIVEN DESIGN OF RESILIENT AND DEPLOYMERIZABLE POLYMERS

(MURI-09) "DISTRIBUTED LEARNING AND INFORMATION DYNAMICS IN NETWORKED AUTONOMOUS SYSTEMS"

NNCI: SOUTHEASTERN NANOTECHNOLOGY INFRASTRUCTURE CORRIDOR (SENIC)

FLAP: FAST, LEXICOGRAPHIC AGILE PERCEPTION INTEGRATES DECISION AND CONTROL IN A SPIKE-RESOLVED, SENSORIMOTOR PROGRAM

LEVERAGING A NEW THEORETICAL PARADIGM TO ENHANCE INTERFACIAL THERMAL TRANSPORT IN WIDE BANDGAP POWER ELECTRONICS

TITLE IS THE GEORGIA TECH CENTER FOR RIBOSOME ADAPTATION AND EVOLUTION IN RESPONSE TO CAN #NNH08Z

ADVANCED MANUFACTURING AND PROTOTYPING INTEGRATED TO UNLOCK POTENTIAL (AMP-IT-UP)

TAS:: 57 3600 ::TAS 'MURI17: CROSS-DISCIPLINARY ELECTRONIC-IONIC RESEARCH ENABLING BIOLOGICALLY REALISTIC AUTONOMOUS LEARNING'

BOTNET ATTRIBUTION AND REMOVAL: FROM AXIOMS TO THEORIES TO PRACTICE

UNIVERSITY TRANSPORTATION CENTER

EPITAXIAL MULTIFUNCTIONAL MATERIALS AND APPLICATIONS: REVOLUTIONARY EPITAXIAL SOLUTIONS CREATING A PLATFORM FOR NEW GENERATION OF MILITARY APPLICATIO

VERTICAL LIFT RESEARCH CENTER OF EXCELLENCE - GEORGIA TECH RESEARCH CORP

FAST AND ACCURATE FABRICATION OF 3-D PHOTONIC AND PHONONIC CRYSTALS BY OPTICAL PATTERNING AND CHEMICAL MODIFICATION

MURI: NEURO-INSPIRED ADAPTIVE PERCEPTION AND CONTROL FOR AGILE MOBILITY OF AUTONOMOUS VEHICLES IN UNCERTAIN AND HOSTILE ENVIRONMENTS

FORMAL FOUNDATIONS OF ALGORITHMIC MATTER AND EMERGENT COMPUTATION

CHARACTERIZATION OF PURIFIED MYOCILIN: GLAUCOMA AS A PROTEIN MISFOLDING DISEASE

MOLECULAR PHOTONICS: HIGH-SPEED MATERIALS FOR OPTICAL SIGNAL PROCESSING

TAS::57 3600::TAS"BIOPAINTS: BIO-ENABLED PARTICLE ADHERENTS FOR INTERROGATIVE SPECTROSCOPY"

MULTIPLE YEAR AWARD WITH INCREMENTAL FUNDING FOR YEARS ONE TO FIVE. THIS PROPOSAL IS ENTITLED RADIATION EFFECTS ON VOLATILES AND EXPLORATION OF ASTEROIDS AND LUNAR SURFACES REVEALS. THIS IS AWARDED IN RESPONSE TO COOPERATIVE AGREEMENT NOTICE CAN NO. NNH16ZDA009C NASA SOLAR SYSTEM EXPLORATION RESEARCH VIRTUAL INSTITUTE SSERVI CYCLE THREE 3. THE PRINCIPAL INVESTIGATOR IS DR. THOMAS M. ORLANDO WITH THE GEORGIA TECH RESEARCH CORPORATION GIT. PROJECT SUMMARY: RECENT SPACE EXPLORATION MISSIONS HAVE REVEALED VOLATILE DEPOSITS ON SEVERAL SOLAR SYSTEM OBJECTS INCLUDING THE MOON MARS MERCURY AND NEAR EARTH ASTEROIDS (NEAS). MOST OF THESE AIRLESS I.E. ZERO-ATMOSPHERE OBJECTS ARE UNDER CONSIDERATION BY NASA AS DESTINATIONS FOR FUTURE HUMAN EXPLORATION. THESE OBJECTS ARE BOMBARDED BY RADIATION (I.E. SOLAR WIND GALACTIC AND SOLAR COSMIC RAYS) AND THE INTERACTION OF RADIATION WITH THEIR SURFACES CAN ALTER AND EVEN PRODUCE VOLATILES. MORE IMPORTANTLY THE CONSTANT RADIATION ASSAULT POSES OBVIOUS LIFE-THREATENING AND PROGRAM-LIMITING HEALTH RISKS. AS A MEMBER OF THE SSERVI THE REVEALS TEAM WILL EXPLORE THE FUNDAMENTAL AND APPLIED ASPECTS CORRELATED WITH RADIATION PROCESSING OF NATURAL REGOLITH AND MAN-MADE COMPOSITE MATERIALS. THE REVEALS TEAM WILL FOCUS ON TWO INTERDISCIPLINARY RESEARCH THEMES EACH COMPRISED OF MULTIPLE TASKS THAT WILL BE CARRIED OUT IN AN INTEGRATED SYSTEMS APPROACH.THEME 1 INTERACTION OF RADIATION AND MICROMETEORITES WITH SURFACE OF AIRLESS BODIES THE SOLAR WIND INTERACTION WITH REGOLITH HAS BEEN IMPLICATED AS A POSSIBLE SOURCE OF VOLATILES (I.E. WATER) THAT CAN BE TRAPPED AND SEQUESTERED IN THE NEAR SURFACE REGION OF THE MOON AND POSSIBLY DEMOS PHOBOS AND NEAS. THE RELEVANT PHYSICAL PROCESSES AND DRIVING INTERACTIONS ARE UNCLEAR. THEREFORE THEME 1 WILL FOCUS ON THREE TASKS: 1) EXAMINE SOLAR WIND MICROMETEORITE PROCESSING OF AIRLESS BODY SURFACES AND DUST IRRADIATION SOURCES 2 DEVELOP MOLECULAR MODELS DESCRIBING RADIATION INDUCED TRANSFORMATION OF REGOLITH 3 EXAMINE THE ROLE OF CHARGING AND ELECTRIC FIELDS ON VOLATILE FORMATION/RELEASE AND 4) TEST SOLAR COLLECTION PANELS AS AN IN SITU RESOURCE UTILIZATION STRATEGY OF PRODUCING WATER FROM REGOLITHTHEME 2 DEVELOPING AND TESTING NEW MATERIALS FOR IMPROVED SAFETY AND HEALTH DURING HUMAN EXPLORATION HUMAN EXPLORATION MISSIONS BEYOND NEAR EARTH ORBIT CANNOT OCCUR WITHOUT A VALIDATED APPROACH TO ADDRESSING ASTRONAUT HEALTH RISKS DUE TO RADIATION. THIS REQUIRES CHARACTERIZATION OF THE SPACE RADIATION ENVIRONMENT EXPERIMENTAL VALIDATION OF RADIATION PROTECTION METHODOLOGIES AND THE ABILITY TO PREDICT AND MONITOR THE RADIATION ABSORBED BY ASTRONAUTS ON A REAL-TIME AND MISSION-INTEGRATED BASIS. AS OF 2016 THE DEEP-SPACE RADIATION ENVIRONMENT IS REASONABLY CHARACTERIZED BUT RADIATION PROTECTION MATERIALS FOR HUMAN HABITATS AND SPACE-SUITS HAVE NOT BEEN FULLY DEVELOPED AND CHARACTERIZED AND REAL-TIME RADIATION MONITORS ARE IN THEIR INFANCY. FOR EXAMPLE REAL-TIME AREA RADIATION MONITORS ARE CURRENTLY UTILIZED ON THE INTERNATIONAL SPACE STATION WITH INCONSISTENT RESULTS AND THEY ARE NOT INTEGRATED WITH SPACE-SUITS. DEVELOPMENT OF STRONG FLEXIBLE AND RADIATION PROTECTIVE MATERIAL IS ALSO LAGGING. THEREFORE THEME 2 WILL FOCUS ON ASSESSING AND MITIGATING HUMAN RADIATION RISKS BY 1 TESTING REGOLITH AS A POTENTIAL SHIELDING MATERIAL 2) DEVELOPING CHARACTERIZING AND TESTING NOVEL COMPOSITE MATERIALS FOR SUPERIOR MECHANICAL THERMAL AND ELECTRICAL PROPERTIES 3 INTEGRATING THE BEST POLYMER COMPOSITES AS MODIFICATION TO EXISTING SPACE-SUITS AND 4 DEVELOPING REAL-TIME LOW WEIGHT AND LOW POWER CONSUMPTION RADIATION MONITORING DEVICES USING GRAPHENE AND OTHER 2D MATERIALS.

NATIONAL INSTITUTE ON DISABILITY AND REHABILITATION RESEARCH - REHABILITATION ENGINEERING RESEARCH CENTERS

INTERPLAY OF INHERENT PROMISCUITY AND SPECIFICITY IN PROTEIN BIOCHEMICAL FUNCTION WITH APPLICATIONS TO DRUG DISCOVERY AND EXOME ANALYSIS

(MURI-05) DYNAMIC FLIGHT MANEUVERING USING VIRTUAL CONTROL SURFACES GENERATED BY TRAPPED VORTICITY

ATLANTIC PEDIATRIC DEVICE CONSORTIUM

MULTIPLE YEAR AWARD AND INCREMENTAL FUNDING FOR YEARS ONE TO THREE. THIS PROPOSAL IS ENTITLED "RELIVING THE PAST: EXPERIMENTAL EVOLUTION OF MAJOR TRANSITIONS IN THE HISTORY OF LIFE - GIT." THIS IS AWARDED IN RESPONSE TO COOPERATIVE AGREEMENT NOTICE (CAN) NO. NNH13ZDA017C NASA ASTROBIOLOGY INSTITUTE CYCLE SEVEN (7). THE PRINCIPAL INVESTIGATOR IS DR. RAPHAEL F. ROSENZWEIG WITH GEORGIA TECH RESEARCH CORPORATION (GIT). PROJECT SUMMARY: TO ILLUMINATE THE LAWS THAT PRODUCE DARWIN'S "TANGLED BANK" REMAINS ONE OF BIOLOGY'S GRAND CHALLENGES ONE THAT REQUIRES UNDERSTANDING HOW DIFFERENCES AMOUNT FORMS ARE SELECTED FOR AND HOW INTERDEPENDENCE AMOUNT FORMS IS ENFORCED. IN NATURAL ENVIRONMENTS MEETING THIS CHALLENGE IS COMPLICATED BY THE FACT THAT SELECTION PRESSURES OFTEN VARY WIDELY OVER SPACE AND THROUGH TIME. LABORATORY EVOLUTION EXPERIMENTS WITH MICROBIAL POPULATION OFFER AN ATTRACTIVE ALTERNATIVE BY WHICH TO STUDY UNDER CONTROLLED CONDITIONS BOTH THE DYNAMIC INTERPLAY BETWEEN GENOTYPE AND PHENOTYPE AND THE INTERACTIONS AMONG PHENOTYPES IN SIMPLE COMMUNITIES. INDEED BECAUSE THE PRINCIPAL ACTORS IN THE FIRST 2.5 BILLION YEARS OF LIFE'S DRAMA WERE EXCLUSIVELY MICROBES WE ARE OBLIGATED TO USE THESE FORMS TO UNLOCK THE SECRETS OF LIFE'S TRANSITIONS FROM SIMPLE AUTOCATALYTIC UNITS TO SELF-ORGANIZING SELF-REPLICATING ENERGY TRANSDUCTION SYSTEMS THAT RANGE IN COMPLEXITY FROM SINGLE CELLS TO ECOSYSTEMS. OUR TEAM IS RESPONDING TO NAI CAN 7 WITH A MULTIDISCIPLINARY PROPOSAL TO ADDRESS: WHAT FORCES BRING ABOUT MAJOR TRANSITIONS IN THE EVOLUTION OF BIO-COMPLEXITY? OUR PROGRAM AIMS TO MEET THE GRANT CHALLENGE OF ILLUMINATING AND INTERPRETING THE LAWS THAT PRODUCE THE "TANGLED BANK" SO THAT WE MAY BETTER UNDERSTAND AND APPRECIATE THE GRANDEUR IN THE VIEW OF LIFE....THAT WHILST THIS PLANET HAS GONE CYCLING ON ACCORDING TO THE FIXED LAW OF GRAVITY FROM SO SIMPLE A BEGINNING ENDLESS FORMS MOST BEAUTIFUL AND MOST WONDERFUL HAVE BEEN AND ARE BEING EVOLVED. THE LAWS ORIGINAL INFERRED BY DARWIN WERE THOSE THAT GIVE RISE TO NATURAL SELECTION WHICH IS A CONSEQUENCE OF NATURAL VARIATION INHERITANCE OF VARIATION AND THE DIFFERENTIAL REPRODUCTION AND SURVIVORSHIP OF VARIANTS ACCORDING TO THEIR FITNESS. 150 YEAR LATER WE NOW RECOGNIZE THE IMPORTANCE OF OTHER FACTORS IN PARTICULAR CHANGE WHETHER IN THE FORM OF GENETIC DRIFT OR HISTORICAL CONTINGENCY. OUR KNOWLEDGE OF THE MECHANISM OF INHERITANCE CONTINUES TO BE REFINED BY NEW INSIGHTS INTO WHAT CONSTITUTES A GENE HOW GENES INTERACT AND HOW MUTATION RATE ITSELF IS SUBJECT TO NATURAL SELECTION. OUR ASTROBIOLOGY PROJECT IS ORGANIZED AROUND A SET OF QUESTIONS RELATED TO MAJOR TRANSITIONS IN THE HISTORY OF LIFE WHEN INDEPENDENTLY REPLICATING ENTITIES COMBINE IN TO LARGER MORE COMPLEX WHOLES: (I) HOW DO ENZYMES AND METABOLIC NETWORKS EVOLVE? (II) HOW DID THE EUKARYOTIC CELL SPECIFICALLY THE CELL THAT CONTAINED A MITOCHONDRION COME TO BE? (III) HOW DO SYMBIOSES ARISE? (IV) HOW DOES MULTICELLULARITY EVOLVE? AND (V) HOW DO PLEIOTROPY EPISTASIS AND MUTATION RATE CONSTRAIN THE EVOLUTION OF NOVEL TRAITS? A UNIFYING THEM UNDERLYING THESE QUESTIONS IS: HOW DO COOPERATIVE VS. COMPETITIVE INTERACTIONS PLAY OUT IN DRIVING MAJOR TRANSITIONS? SEEKING THE ANSWERS TO THESE QUESTIONS FALLS SQUARELY WITHIN ASTROBIOLOGY WHICH IS THE STUDY OF THE ORIGINS EVOLUTION DISTRIBUTION AND FUTURE OF LIFE IN THE UNIVERSE AND HELPS TO ADDRESS THE FIRST OF OUR DISCIPLINE'S THREE PRINCIPAL QUESTIONS: HOW DOES LIFE BEGIN AND EVOLVE?

THE OVERARCHING TECHNICAL OBJECTIVE OF THE PROPOSED NASA ULI IS TO OVERCOME BARRIERS TO REDUCING THE ENVIRONMENTAL IMPACT OF FUTURE CIVIL SUPERSONIC TRANSPORT (CST) THROUGH A TIGHTLY INTEGRATED PROGRAM OF LOW-EMISSION COMBUSTOR TECHNOLOGY DEVELOPMENT

FINDING SLEEPING BEAUTY: T CELL BIOSENSORS FOR DORMANT CANCER DETECTION - PROJECT SUMMARY SOME TYPES OF CANCERS, AS EXEMPLIFIED BY ESTROGEN RECEPTOR POSITIVE BREAST CANCER, CAN RECUR AS METASTATIC DISEASE MANY YEARS OR EVEN DECADES FOLLOWING A DORMANCY PERIOD WHERE THE PATIENT DISPLAYS NO CLINICAL SYMPTOMS. LATE RECURRENCE IS THOUGHT TO ARISE FROM DISSEMINATED TUMOR CELLS (DTCS) THAT WERE NOT KILLED BY INITIAL TREATMENT AND THAT LIE DORMANT AT METASTATIC SITES SUCH AS THE BONE MARROW UNTIL THEY REAWAKEN. STRIKINGLY, META- ANALYSIS OF OVER 60,000 EARLY-STAGE ER-POSITIVE BREAST CANCER PATIENTS TREATED WITH ENDOCRINE THERAPY REVEALED THAT THE RELATIVE RISK OF RECURRENCE PROGRESSIVELY INCREASES OVER A PERIOD OF AT LEAST 20 YEARS, INDICATING THAT PATIENTS IN COMPLETE REMISSION WITH NO EVIDENCE OF DISEASE COULD HARBOR DORMANT CANCER AND REMAIN AT RISK OF METASTATIC RELAPSE FOR THE REMAINDER OF THEIR LIFE. CURRENTLY, THERE IS NO WIDELY USED METHOD TO MONITOR THE DORMANT STATE NOR ITS REAWAKENING. THE ARRIVAL OF CANCER IMMUNOTHERAPY HAS REVEALED EXCITING POSSIBILITIES USING ENGINEERED T CELLS AS LIVING MEDICINES. T CELLS DESIGNED WITH TUMOR-TARGETING RECEPTORS AND SOPHISTICATED GENETIC CIRCUITS HAVE LED TO STRIKING TREATMENT RESPONSES IN PATIENTS WITH CERTAIN TYPES OF CANCERS THAT WERE PREVIOUSLY UNTREATABLE. THIS MOMENT IS AN OPPORTUNITY TO NOT ONLY BUILD A FUTURE WHERE T CELLS ARE ENGINEERED AS THERAPIES, BUT ALSO AS LIVING SENSORS THAT CAN DETECT CANCER WITH SENSITIVITIES AND SPECIFICITIES BEYOND WHAT IS CURRENTLY POSSIBLE. THE ACTIVATION AND GROWTH OF DORMANT TUMOR CELLS INTO MICRO-METASTASES REQUIRE THE HALLMARK EXPRESSION OF PROTEASES DURING KEY STEPS SUCH AS ANGIOGENESIS. TO EXPLOIT PROTEASE DYSREGULATION, THIS PROJECT WILL DEVELOP ENGINEERED RECEPTORS THAT SENSE PROTEOLYSIS TO DETECT REAWAKENING. THESE CONTAIN AN EXTRACELLULAR SINGLE CHAIN ANTIBODY THAT IS BLOCKED BY A PEPTIDE MIMOTOPE SUCH THAT THEY CAN BIND TO THEIR COGNATE ANTIGENS ONLY AFTER THE BLOCKING PEPTIDE IS REMOVED BY PROTEOLYSIS, RESTRICTING T CELL ACTIVATION TO THE SPECIFIC CONDITION WHERE THE COGNATE PROTEASE AND TUMOR ANTIGEN ARE BOTH PRESENT. FOLLOWING ACTIVATION, T CELL SENSORS AMPLIFY THE RELEASE OF SYNTHETIC BIOMARKERS (BLOOD, URINE AND IMAGING) FOR DETECTION. GENETICALLY ENCODED LIBRARIES (>10^4) OF PROTEASE-ACTIVATABLE RECEPTORS WILL ALLOW IN VIVO SCREENING OF 1000S OF CANDIDATE T CELL SENSORS TO POSITIVELY AND NEGATIVELY SELECT FOR CONSTRUCTS THAT CAN REPORT ON AWAKENING IN DIFFERENT MICROENVIRONMENTS SUCH AS THE BONE MARROW AND LUNGS. THE ADOPTIVE TRANSFER OF T CELL SENSORS WITH MEMORY PHENOTYPE COULD LEAD TO LIFE-LONG T CELL SENSORS THAT CONTINUOUSLY MONITOR FOR FUTURE DISEASE. THESE TECHNOLOGICAL BREAKTHROUGHS WILL HAVE HUGE IMPLICATIONS IN UNDERSTANDING HOW AND WHEN DORMANT CELLS REAWAKEN AND GUIDE THERAPEUTIC INTERVENTIONS AT THE EARLIEST STAGES OF REACTIVATION.

HUMAN FACTORS AWARENESS TRAINING FOR FAA SAFETY SPECIALISTS WITHIN AIRCRAFT CERTIFICATION

MODELING OF VEHICLE ENVIRONMENTAL CHARACTERISTICS INCLUDING NEW TECHNOLOGIES/CONCEPTS FOR THE NEXT GENERATION AIR TRANSPORTATION SYSTEM\NASDL AND THE

THE OVERARCHING RESEARCH OBJECTIVE SEEKS TO IMPROVE ACCESSIBILITY AFFORDABILITY AND SAFETY BY DEVELOPING SIMULATION TOOLS AND OPERATIONAL PROCESSES TO OPTIMIZE THE COST SAFETY AND PERFORMANCE OF CIVILIAN VERTICAL LIFT AIR VEHICLES

EXPLORATION, CONSERVATION, & DEVELOPMENT OF MARINE BIODIVERSITY IN FIJI AND THE S

NATIONAL INFORMATION EXCHANGE MODEL (NIEM) DEVELOPMENT SUPPORT PROJECT

TAS::57 3600::TAS "(MURI 11) MULTI-FUNCTIONAL LIGHT-MATTER INTERFACES BASED ON NEUTRAL ATOMS AND SOLIDS," DATED 02 DEC 2010

I-CORPS NODE: I-CORPS SOUTH

BASIC PRINCIPLES THAT GOVERN THE INTERACTION ORGANOMETALLIC CATALYSTS WITH SUPPORTS - THE SCIENCE OF IMMOBILIZED MOLECULAR CATALYSTS

EXPLORATION, CONSERVATION, AND DEVELOPMENT OF MARINE BI*

PORT SECURITY GRANT PROGRAM

THIS IS A MURI CONTINUATION OF N00014-14-1-0580 CENTER FOR ADVANCED ORGANIC PHOTOVOLTAICS.

HUMAN SIGNATURES FOR PERSONNEL DETECTION

THE PROPOSED PROJECT AIMS TO DEVELOP THE FUNDAMENTAL KNOWLEDGE AND TOOLS TO DESIGN ADAPTIVE COASTAL INFRASTRUCTURE AND EQUITABLE RESILIENCE STRATEGIES UNDER PROJECTED FUTURE SEA-LEVEL RISE SCENARIOS ALONG THE VULNERABLE GEORGIA COASTLINE. THIS PROJECT IN PARTICULAR HAS A STRONG FOCUS ON LOW-INCOME, HISTORICALLY MARGINALIZED COMMUNITIES OF COLOR IN SAVANNAH, GEORGIA, BUILDING ON EXISTING PARTNERSHIPS BETWEEN GEORGIA TECH, CITY AND COUNTY OFFICIALS, AND SEVERAL LOCAL ENVIRONMENTAL JUSTICE ORGANIZATIONS. THE PROJECT WILL BUILD ON AN EXISTING NETWORK OF 50 "SMART SEA LEVEL SENSORS" (SEALEVELSENSORS.ORG) AND A STATE OF THE ART WATER-LEVEL MODELING AND FORECASTING SYSTEM BASED IN CHATHAM COUNTY, EXPANDING THE SENSOR NETWORK AND MODELING ALONG THE GEORGIA COASTLINE, INCLUDING INSTALLATIONS IN GLYNN COUNTY, CAMDEN COUNTY, AND THE KING'S BAY NAVAL BASE. THE NETWORK AND MODELING WILL BE THE FOUNDATION OF A GA STAKEHOLDER DECISION SUPPORT SYSTEM (GA-SDSS) THAT WILL PROVIDE REAL-

NSF-SIMONS SOUTHEAST CENTER FOR MATHEMATICS AND BIOLOGY

GEORGIA TECH'S SCHOLARSHIP-FOR-SERVICE (SFS) PROGRAM

RESEARCH ON VERTICAL LIFT TECHNOLOGY

ENGINE OF INNOVATION: HOW COMPARTMENTALIZATION DRIVES EVOLUTION OF NOVELTY AND.EFFICIENCY ACROSS SCALES

HEARTBEAT: HELIOSPHERE TO EARTH ATMOSPHERE RENDERING THROUGH BUILDING EXCELLENT ARTIFICIAL-INTELLIGENCE TRAINING - NEW AWARD

CENTER FOR LUNAR ENVIRONMENT AND VOLATILE EXPLORATION RESEARCH (CLEVER)

THE PROJECT GOAL IS TO COUPLE THE NUTRIENT AND WATER RESOURCES IN DOMESTIC WASTEWATER TO URBAN CONTROLLED ENVIRONMENT AGRICULTURE SYSTEMS (DWW-CEAS). SUPPORTING OBJECTIVES INCLUDE 1) CONFIRMING THAT PRODUCE GROWTH RATES AND QUALITY DON'T DIMINISH COMPARED TO CONTROL EXPERIMENTS WHERE SYNTHETIC HYDROPONIC FERTILIZERS ARE USED, 2) CONFIRMING THAT CHEMICAL CONTAMINANTS DON'T ACCUMULATE IN THE PRODUCE, 3) CONFIRMING THAT THE PRODUCE IS PATHOGEN FREE, 4) REDUCING DWW TREATMENT COSTS BY USING THE LATEST IN ENERGY-POSITIVE TREATMENT TECHNOLOGY, 5) DEVELOPING A SUSTAINABLE FOOD, ENERGY AND WATER (FEW) SYSTEM USING MODELLING APPROACHES TO MINIMIZE INVESTMENTS IN DWW-CEA SYSTEMS WHILE MAXIMIZING THE UTILITY OF THE SYSTEMS, 6) PROVIDING AN EDUCATION IN SCIENCE, TECHNOLOGY, ENGINEERING, ART AND MATHEMATICS IN HIGH-TECH WASTEWATER TREATMENT AND CEA TECHNOLOGIES, 7) DEVELOPING A VETERAN WORKFORCE TO HELP OPERATE DWW-CEAS, AND 8) GUIDING LOCAL POLICY TO PROVIDE SUSTAINABLE AND LONG-LASTING SOLUTIONS TO CONSERVE OUR PRECIOUS NUTRIENT AND WATER RESOURCES. TO ACCOMPLISH THE PROJECT GOAL, A PILOT-SCALE HYDROPONIC SYSTEM WILL BE CONSTRUCTED AND OPERATED USING DWW MINED FROM THE SEWER SYSTEM ON THE GEORGIA TECH CAMPUS. THE DWW WILL BE TREATED TO REMOVE CONTAMINANTS AND PATHOGENS BEFORE BEING USED TO IRRIGATE HYDROPONIC SYSTEMS TO ASSURE FOOD AND FARM WORKER SAFETY. MULTIPLE FRUIT AND VEGETABLE VARIETIES WILL BE GROWN YEAR-ROUND. WATER QUALITY AND CHEMICAL AND MICROORGANISM CONTAMINATION WILL BE MEASURED CONTINOUSLY. THE PROJECT WILL SHOW THAT DWW-CEAS ARE SOCIALLY, ENVIRONMENTALLY AND FINANCIALLY SUSTAINABLE, EASILY REPLICABLE IN URBAN AREAS AND WILL PROVIDE A LONG-LASTING SOLUTION TO CONSERVE OUR PRECIOUS WATER RESOURCES FOR FOOD PRODUCTION.

AGEP: FACES: FACILITATING ACADEMIC CAREERS IN ENGINEERING AND SCIENCE

TAS::89 0336::TAS RECOVERY MODULAR THERMAL HUB FOR BUILDING COOLING, HEATING AND WATER HEATING THIS TEAM LED BY GEORGIA TECH WILL DEVELOP A

FAILURE MECHANISMS OF NEURAL ELECTRODES

REHABILITATION ENGINEERING RESEARCH CENTERS

RESEARCH TRAINING PROGRAM PLAN ON CELL AND TISSUE ENGINEERING (CTENG)

PROBING POLYMICROBIAL SYNERGY USING HIGH THROUGHPUT GENOMICS

TAS::57 3600::TAS "(MURI 10) - CENTER FOR ORGANIC MATERIALS FOR ALL OPTICAL SWITCHING"

THE COOL TEAM WILL CONDUCT AN INTERDISCIPLINARY INVESTIGATION OF THE ORIGINS EVOLUTION AND SIGNIFICANCE OF TRANSLATION WHICH IS A WINDOW TO PRIMEVAL EVENTS AND MOLECULAR STRUCTURES. WE WILL INTEGRATE BIOPHYSICAL STRUCTURAL BIOINFORMATIC BIOCHEMICAL CHEMICAL AND EVOLUTIONARY APPROACHES TO UNDERSTAND BIOLOGY S INTERNAL FOSSIL RECORD . OUR OVERRIDING SCIENTIFIC QUESTION IS: HOW DID THE ORIGINAL AND MOST PROFOUND MUTUALISTIC RELATIONSHIP IN BIOLOGY OF POLYPEPTIDE AND POLYNUCLEOTIDE TAKE ROOT AND ULTIMATELY COME TO DEFINE AND RULE THE BIOLOGICAL EARTH? THE CENTRAL QUESTION WILL BE FRAMED BY FOUR THEMES: (THEME 1) EVOLUTION OF TRANSLATION IN VIVO (THEME 2) EVOLUTION OF TRANSLATION IN VITRO (THEME 3) WALKING BACK FROM EXTANT BIOLOGY AND (THEME 4) ORIGINS OF MOLECULAR MUTUALISM.

RERC ON TECHNOLOGIES TO SUPPORT SUCCESSFUL AGING IN PLACE WITH LONG-TERM DISABILITY (TECHSAGE RERC II)

RERC ON WIRELESS INCLUSIVE TECHNOLOGIES

REHABILITATION ENGINEERING RESEARCH CENTERS

BIO-INSPIRED MATERIAL ARCHITECTURES FOR DEEP SEA (BIMADS)

COMPREHENSIVE SYSTEM DEBLOATING VIA PATH BASED LEARNING & LATE STAGE OS COMPOSITION

ZENO-BASED OPTO-ELECTRONIC (ZOE)

PATTERNING THE VERTEBRATE DENTITION THROUGH REPLACEMENT AND REPAIR

SOUTHEASTERN TAAC

FY 2008 PORT SECURITY GRANT PROGRAM

MANUFACTURING SCIENCE FOR PRODUCING HYDROGEN ENERGY FROM GALVANIC ALUMINUM

GEORGIA SPACE GRANT CONSORTIUM: NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM - OPPORTUNITIES IN NASA STEM FY 2020-2024

UNDERSTANDING AND BUILDING OVERALL COGNITIVE CAPABILITY THROUGH ATTENTION CONTROL (22-000002428)

MULTI-SENSOR INSPECTION AND ROBOTIC SYSTEMS FOR DRY STORAGE CASKS

FRICTION AND WEAR UNDER VERY HIGH ELECTROMAGNETIC STRESS

RESEARCH TRAINING IN COGNITIVE AGING

THE GEORGIA INSTITUTE OF TECHNOLOGY (GT) IS HOME TO ONE OF THE LARGEST UNIVERSITY COMBUSTION LABORATORIES IN THE WORLD, WITH MAJOR RESEARCH AND EVALUATION INFRASTRUCTURE THAT HAS FOSTERED DEEP RELATIONSHIPS TO GLOBAL HYDROCARBON FUEL UTILIZATION COMMUNITIES. GAS TURBINE MANUFACTURERS, ELECTRIC UTILITIES, INDUSTRIAL EQUIPMENT MANUFACTURERS, AIRCRAFT ENGINE MANUFACTURERS, RECIPROCATING ENGINE MANUFACTURERS, AND DOE LABS ALL CONDUCT RESEARCH AND SUPPORT STUDENT TRAINING AT THE GT COMBUSTION LABORATORY. THIS PROJECT WILL CREATE NEW RESEARCH AND EDUCATION INFRASTRUCTURE, FOCUSED ON ENABLING THE FUTURE USE OF HYDROGEN AND AMMONIA AS PRACTICAL ENERGY CARRIERS. SPECIFICALLY, THE PROJECT WILL FUND THE PURCHASE, INSTALLATION, AND COMMISSIONING OF (1) HYDROGEN GENERATION/STORAGE AND DISTRIBUTION EQUIPMENT; (2) AMMONIA STORAGE, SAFETY, VAPORIZATION, AND DISTRIBUTION EQUIPMENT; AND (3) AIR COMPRESSION, HEATING, AND DISTRIBUTION INFRASTRUCTURE NEEDED TO REPLICATE PRACTICAL INDUSTRIAL CONDITIONS; AND (4) A HYDROGEN FUEL CELL FACILITY. IT ALSO WILL SUPPORT COLLABORATIVE RESEARCH AND TRAINING OPPORTUNITIES, THROUGH WHICH GT AND CAU STUDENTS TO LEARN IN THE OTHER INSTITUTE’S FACILITIES, PRIMARILY THROUGH FUNDED RESEARCH ASSISTANTSHIPS.

NEW COMPETITIVE AWARD UNDER DE-FOA-0001953, TOPIC U: SF6-FREE GEORGIA INSTITUTE OF TECHNOLOGY CONTROL NUMBER 1953-1924 PROJECT TITLE: TESLA -- TOUGH AND ECOLOGICAL SUPERCRITICAL LINE BREAKER FOR AC

GEORGIA TECH WILL SERVE AS THE LEAD INSTITUTION FOR THE PROJECT. DR. BRITNEY SCHMIDT WILL ACT AS PRINCIPAL INVESTIGATOR TO OVERSEE AND GUARANTEE SCIE

MECHANISMS OF IMPAIRED T-CELL MECHANOSENSING OF MELANOMA ANTIGENS

SPARKING PROGRESS IN BATTERY MANUFACTURING THIS PROJECT WILL FOCUS ON ACQUIRING EQUIPMENT TO OUTFIT A RESEARCH FACILITY FOR BATTERY RESEARCH AND DEVELOPMENT (R&D) AT GEORGIA TECH. THE PURPOSE OF THIS FACILITY WILL BE TO SUPPORT FUNDAMENTAL AND APPLIED R&D TO COMPLEMENT THE EMERGING BATTERY AND ELECTRIC VEHICLE INDUSTRY IN THE SOUTHEAST REGION OF THE UNITED STATES, AND TO EDUCATE STUDENTS IN THIS SPACE.

PROPOSAL GOALS ON JUPITERS INNERMOST ICY MOON EUROPA, THE UNIQUE COMBINATION OF AN ACTIVE ICE SHELL AND ROCKY, POSSIBLY MAGMATIC INTERIOR MAY GIVE

SINGLE-PLATELET ANALYSIS OF MECHANO-RECEPTION BY GPIB ALPHA

INDUSTRIAL ASSESSMENT CENTERS PROGRAM - SOUTHEASTERN CENTER OF EXCELLENCE

GEORGIA INSTITUTE OF TECHNOLOGY CONTROL NUMBER 2171-1573 PERFORMANCE-BASED ENERGY RESOURCE FEEDBACK, OPTIMIZATION, AND RISK MANAGEMENT (PERFORM) NEW AWARD TO GEORGIA TECH RESEARCH CORPORATION FOR A PROJECT ENTITLED: ''RISK-AWARE MARKET CLEARING FOR POWER SYSTEMS.''

MRI: ACQUISITION OF AN HPC SYSTEM FOR DATA-DRIVEN DISCOVERY IN COMPUTATIONAL ASTROPHYSICS, BIOLOGY, CHEMISTRY, AND MATERIALS SCIENCE

FIRST IN THE WORLD

GCR: BIOMOLECULAR SYSTEMS ENGINEERING - UNLOCKING THE POTENTIAL OF BIOLOGICAL PROGRAMMING

1979-1524 GEORGIA INSTITUTE OF TECHNOLOGY ''PURE SOLID-STATE CIRCUIT BREAKERS FALL UNDER A NEW CLASS OF SWITCHGEAR WITH FAST SWITCHING SPEED AND FAULT CURRENT LIMITATION. THESE CIRCUIT BREAKERS CAN BE DESIGNED TO CLEAR FAULTS IN DC OR AC POWER SYSTEMS – INCLUDING BIDIRECTIONAL OPERATION IN DC POWER SYSTEMS. THEY ARE LESS PRONE TO WEAR THAN THEIR MECHANICAL COUNTERPARTS, AND OFTEN DO NOT REQUIRE MAINTENANCE. HOWEVER, THESE ADVANTAGES OVER MECHANICAL CIRCUIT BREAKERS ALSO COME WITH A CRUCIAL DISADVANTAGE: THE ON-STATE LOSSES OF POWER SEMICONDUCTORS DEVICES ARE MUCH HIGHER THAN THOSE IN MECHANICAL CONTACTS, LEADING TO SIGNIFICANT POWER LOSS AND HEATING IN SOLID-STATE SWITCHGEAR.''

TAS::97 0400::TAS PETABLOX: LARGE SCALE SOFTWARE ANALYSIS AND ANALYTICS USING DATALOG

ELECTRIC POWER GENERATION BY A VERTICAL AXIS TURBINE DRIVEN BY AN ANCHORED VORTEX AND SUSTAINED BY THE AIR LAYER OVER SOLAR-HEATED GROUND

IGERT: STEM CELL BIOMANUFACTURING

HIGH EFFICIENCY SOLAR FUELS REACTOR CONCEPT

EXPLORING SINGLE-MOLECULE BIOPHOTONICS FOR ULTRAHIGH-RESOLUTION SPATIOTEMPORAL-MULTIPLEXED OPTICAL MICROSCOPY

OLFACTORY RECEPTOR-BASED SENSORS FOR BIOMEDICAL APPLICATIONS

THE OBJECTIVE OF THIS PROJECT IS TO COMBINE STATE-OF-THE-ART ALKALINE POLYMER ELECTROLYZER COMPONENTS, WITH ADVANCED MANUFACTURING METHODS AND CELL OPERATING CONDITIONS TO MEET FOA GOALS (2.0 A/CM2, <1.8 V AND <4 MV/KHR) TO ACHIEVE $2/KGH2. THE OBJECTIVES OF BUDGET PERIOD (BP) 1 INCLUDE DEVELOPING ANION EXCHANGE MEMBRANE (AEM) ROLL-TO-ROLL (R2R) PARAMETERS AS WELL AS INTRODUCING AND OPTIMIZING DURABLE ELECTRODES USING SELF-ADHESIVE IONOMERS, LOW-COST CATALYSTS, AND NEW MEMBRANE ELECTRODE ASSEMBLY (MEA) ASSEMBLY METHODS. THE WORK IN BP2 WILL ALLOW OUR TEAM TO DEMONSTRATE A NEW AEM R2R MANUFACTURING METHOD, IMPLEMENT NEW ELECTROLYZER OPERATING MODES (INCLUDING HIGH ION-STRENGTH ELECTROLYTE WITHOUT AN INCREASE IN PH), AND ELECTRODE DEPOSITION METHODS TO SIMULTANEOUSLY IMPROVE VOLTAGE AND DURABILITY. BP3 FOCUSES ON DETAILED DEGRADATION STUDIES, MODELING, MITIGATION STRATEGIES (IF NEEDED), LARGE-SCALE SYSTEM DEMONSTRATIONS AND COMMERCIALIZATION EVALUATION.

FODAVA-LEAD: DIMENSION REDUCTION AND DATA REDUCTION: FOUNDATIONS FOR VISUALIZATION

EXPLOITING THE MECHANOBIOLOGY OF PD-1 FOR CANCER IMMUNOTHERAPY

HUMAN SPECIFIC BRAIN DNA METHYLATION AND NEUROPSYCHIATRIC DISEASES

GEORGIA TECH RESEARCH CORPORATION

SOCINT: SOCIAL SIGNALS FOR IDENTIFYING AND USING INFLUENTIAL SUBNETWORKS

UNIVERSITY TRANSPORTATION CENTER - INVESTING IN THE NATIONAL TRANSPORTATION SYSTEM: ECONOMIC GROWTH, SYSTEM PRODUCTIVITY, AND FINANCE.

ADVANCED DESIGN STUDIES

OVERCOMING THE FUNDAMENTAL BOTTLENECKS TO A NEW WORLD-RECORD SILICON SOLAR CELL

NNCI COORDINATING OFFICE AT GEORGIA TECH

SCIENCE LEARNING: INTEGRATING DESIGN, ENGINEERING AND ROBOTICS (SLIDER)

PRECISION MAPPING OF REGULATORY CAUSAL VARIANTS BY EXPRESSION CROPSEQ - ABSTRACT GENETIC DIFFERENCES AMONG INDIVIDUALS ULTIMATELY TRACE TO SINGLE NUCLEOTIDE POLYMORPHISMS, THE MAJORITY OF WHICH AFFECT TRAITS, INCLUDING DISEASE SUSCEPTIBILITY, BY INFLUENCING THE EXPRESSION OF NEARBY GENES. OVER THE PAST DECADE, TENS OF THOUSANDS OF LOCI OF THIS TYPE HAVE BEEN MAPPED TO WHAT ARE CALLED CREDIBLE INTERVALS, NAMELY SETS OF ANYWHERE FROM A HANDFUL TO OVER ONE HUNDRED POLYMORPHISMS THAT HAVE SIMILAR STATISTICAL SIGNALS. THE NEXT STEP IS TO RESOLVE THE IDENTITIES OF THE CAUSAL VARIANT(S) WITHIN THESE CREDIBLE INTERVALS. SIMILARLY, THERE IS A PARALLEL PRESSING NEED TO VALIDATE THAT DE NOVO AND ULTRA-RARE VARIANTS IN THE PROMOTER OF A GENE THOUGHT TO CONTRIBUTE TO A CONGENITAL ABNORMALITY ACTUALLY DISRUPT EXPRESSION OF THE GENE. THIS PROJECT PROPOSES A SYSTEMATIC EFFORT TO FINE MAP CAUSAL VARIANTS FOR HUNDREDS OF GENES THAT INFLUENCE AUTOIMMUNE AND OTHER IMMUNE CONDITIONS. IT UTILIZES A COMBINATION OF GENOME ENGINEERING AND SINGLE CELL GENOMICS, IN A RECENTLY DEVELOPED ASSAY CALLED EXPRESSION CROP-SEQ, OR ECROPSEQ. THE IDEA IS TO KNOCK OUT EACH OF THE VARIANTS IN A CREDIBLE INTERVAL WITH A POOL OF CRISPR-CAS9 GUIDE RNAS, EACH TARGETING ONE SNP FOR MICRODELETION OF MUTATION, AND TAKEN UP BY ABOUT 100 CELLS. THE EXPRESSION OF THE GENE IN THOSE CELLS IS THEN COMPARED WITH THE EXPRESSION IN ALL OTHER CELLS THAT RECEIVE DIFFERENT GUIDE RNAS IN THE SAME EXPERIMENT. AIM 1 IS TO USE ECROPSEQ TO IDENTIFY CAUSAL VARIANTS IN UP TO 600 CREDIBLE INTERVALS ASSOCIATED WITH 350 IMMUNE LOCI, MEASURED IN BOTH A MYELOID (HL60) AND LYMPHOID (JURKAT) CELL LINE. AIM 2 IS TO PERFORM A SIMILAR ANALYSIS OF UP TO 500 RARE VARIANTS IN THE PROMOTER REGIONS OF THESE GENES TO EVALUATE WHETHER NEW MUTATIONS CAN CAUSE EXTREME LEVELS OF ABERRANT GENE EXPRESSION. WITH THESE RESULTS IN HAND, AIM 3 UTILIZES A MORE PRECISE GENOME EDITING TOOL, SEARCH-AND-REPLACE CRISPR (ALSO KNOWN AS PRIME EDITING) TO SUBSTITUTE ONE ALLELE FOR ANOTHER INSTEAD OF JUST EVALUATING MUTATIONS. THEN AIM 4 ASKS WHETHER THE EFFECTS OBSERVED IN THE CELL LINES ARE ALSO SEEN IN PRIMARY T CELLS FROM EIGHT DIFFERENT PEOPLE, AND WHETHER THE MAGNITUDE OF EFFECT DIFFERS AMONG PEOPLE. COLLECTIVELY THE PROPOSED EXPERIMENTS WILL SYSTEMATICALLY MAP THE CAUSAL REGULATORY VARIANTS FOR HUNDREDS OF AUTOIMMUNE GENES, AND ESTABLISH A TOOL THAT SHOULD BE READILY ADAPTED BY EVEN SMALL LABS TO TEST THE FUNCTION OF NEW GENOME-WIDE ASSOCIATIONS.

GEORGIA TECH RESEARCH CORPORATION - NEW AWARD CONTROL NUMBER: 1858-2466 HIGH POWER DENSITY COMPACT DRIVE INTEGRATED MOTOR FOR ELECTRIC TRANSPORTATION

MODEL-BASED PREDICTION OF REDOX-MODULATED RESPONSES TO CANCER TREATMENTS

THE GEORGIA SPACE GRANT CONSORTIUM GSGC EXISTS AS A RESULT OF THE 1989 NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP ACT. THE GSGC SUPPORTS STEM EDUCAT

HYDROGELS FOR HMSC DELIVERY & ENGRAFTMENT

COLLABORATIVE RESEARCH: COMPUTATIONAL BEHAVIORAL SCIENCE: MODELING ANALYSIS AND VISUALIZATION OF SOCIAL AND COMMUNICATIVE BEHAVIOR

THE GEORGIA SPACE GRANT CONSORTIUM (GSGC) EXISTS AS A RESULT OF THE 1989 NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP ACT. THE GSGC SUPPORTS STEM EDUC

"TRANSCRANIAL FUS THERAPY WITH CLOSED-LOOP US IMAGE GUIDANCE AND CIRCULATING TUMOR DNA

HYDROGELS FOR HUMAN BETA CELL SURVIVAL, FUNCTION AND EVASION OF IMMUNE REJECTION - PROJECT SUMMARY TYPE 1 DIABETES (T1D) IS AN AUTOIMMUNE DISEASE IN WHICH THE INSULIN-PRODUCING SS-CELLS OF THE PANCREAS ARE DESTROYED. T1D AFFECTS 3 MILLION CHILDREN AND ADULTS IN THE US WITH HEALTHCARE COSTS EXCEEDING $15 BILLION. STANDARD THERAPY WITH EXOGENOUS INSULIN IS BURDENSOME, ASSOCIATED WITH A SIGNIFICANT DANGER OF HYPOGLYCEMIA, AND ONLY PARTIALLY EFFICACIOUS IN PREVENTING LONG-TERM COMPLICATIONS. TRANSPLANTATION OF ALLOGENEIC ISLETS FROM CADAVERIC DONORS IN CONJUNCTION WITH CHRONIC IMMUNOSUPPRESSION HAS BEEN RECENTLY SHOWN TO BE EFFECTIVE IN RESTORING EUGLYCEMIA IN CLINICAL TRIALS. HOWEVER, THE LONG-TERM FUTURE OF CELL REPLACEMENT THERAPY FOR T1D REQUIRES A RELIABLE AND REPLENISHABLE SS-CELL SOURCE AND ELIMINATION OF THE NEED FOR CHRONIC IMMUNOSUPPRESSION. SS-CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS (SC-SS CELLS) REPRESENT A TRANSFORMATIVE, UNLIMITED SOURCE OF INSULIN- PRODUCING CELLS FOR THE TREATMENT OF T1D. DESPITE ADVANCES IN ENGINEERING FUNCTIONAL INSULIN-PRODUCING SC-SS CELLS, SIGNIFICANT BARRIERS RELATED TO LONG-TERM ENGRAFTMENT AND FUNCTION WITHOUT CHRONIC IMMUNOSUPPRESSION HINDER THE CLINICAL TRANSLATION OF THESE PROMISING CELLS. FURTHERMORE, THE USE OF ENCAPSULATION DEVICES TO PROTECT TRANSPLANTED CELLS HAS NOT BEEN SUCCESSFUL IN LARGE ANIMAL MODELS DUE TO FIBROTIC RESPONSES AND LACK OF DIRECT VASCULARIZATION. OUR OBJECTIVE IS TO ENGINEER ADVANCED BIOMATERIAL DELIVERY TECHNOLOGIES TO (I) ENHANCE VASCULARIZATION, SURVIVAL, AND ENGRAFTMENT OF SC-SS CELLS AND (II) PROTECT THEM FROM REJECTION BY THE IMMUNE SYSTEM WITHOUT THE NEED FOR ENCAPSULATION OR CHRONIC IMMUNOSUPPRESSION. WE HYPOTHESIZE THAT SYNTHETIC HYDROGELS WITH CONTROLLED PRESENTATION OF VASCULOGENIC AND IMMUNOMODULATORY SIGNALS WILL PROVIDE AN INJECTABLE DELIVERY VEHICLE THAT DIRECTS SC-SS CELL SURVIVAL, ENGRAFTMENT, AND FUNCTION WITHOUT CHRONIC IMMUNOSUPPRESSION OR ENCAPSULATION. AIM 1: ENGINEER INJECTABLE VEGF-DELIVERING HYDROGELS TO PROMOTE VASCULARIZATION, SURVIVAL, AND FUNCTION OF SC- SS CELLS TRANSPLANTED IN THE SUBCUTANEOUS SPACE OF DIABETIC, IMMUNOCOMPROMISED MICE. AIM 2: EVALUATE OUR SA- FASL-MICROGEL TECHNOLOGY TO PROMOTE SC-SS CELL IMMUNE ACCEPTANCE AND FUNCTION IN DIABETIC, IMMUNOCOMPETENT HUMANIZED MICE WITHOUT CHRONIC IMMUNOSUPPRESSION. AIM 3: EXAMINE THE ABILITY OF VEGF/SA-FASL HYDROGELS TO ENHANCE SC-SS CELL SURVIVAL AND FUNCTION IN DIABETIC NONHUMAN PRIMATES WITH NO OR REDUCED CHRONIC IMMUNOSUPPRESSION IN A PILOT STUDY. THIS HIGHLY SIGNIFICANT AND INNOVATIVE STRATEGY IS FUNDAMENTALLY DIFFERENT FROM ONGOING WORK IN THE FIELD IN TERMS OF ENGINEERING ADVANCED INJECTABLE BIOMATERIALS THAT PROMOTE SC-SS CELL VASCULARIZATION, LOCAL IMMUNE ACCEPTANCE, SURVIVAL, AND FUNCTION WITHOUT ENCAPSULATION IN DEVICES OR SYSTEMIC IMMUNOSUPPRESSION. FURTHERMORE, THE FOCUS ON HUMANIZED MURINE AND NONHUMAN PRIMATE MODELS WILL ACCELERATE THE DEVELOPMENT OF AN EFFECTIVE AND BROADLY APPLICABLE CURE FOR T1D.

SCALING INTEROPERABLE TRUST THROUGH A TRUSTMARK MARKETPLACE

METABOLITE SENSING IN AN ORAL POLYMICROBIAL COMMUNITY

SITUATIONAL AWARENESS THROUGH CYBER-PHYSICAL MODELING AND SIMULATION (SACPS)

ENGINEERING PROTEIN ANTIGENS AND THEIR PRESENTATION FROM MULTIVALENT SCAFFOLDS - THE OBJECTIVE OF THE PROPOSED WORK IS TO DEVELOP A VACCINE THAT PROVIDES BROAD PROTECTION AGAINST GROUP 1 INFLUENZA A VIRUSES – A GROUP THAT INCLUDES THE 1918, 1957-1958, AND 2009 PANDEMIC VIRUSES, AS WELL AS AVIAN INFLUENZA “VIRUSES OF CONCERN” – BY ELICITING A ROBUST AND DURABLE IMMUNE RESPONSE TARGETING THE HIGHLY CONSERVED MEMBRANE-PROXIMAL STALK DOMAIN OF HEMAGGLUTININ (HA). THE PROJECT WILL TEST THE HYPOTHESIS THAT THE COMBINATION OF SHIELDING THE VARIABLE HEAD DOMAIN OF HA, REFOCUSING THE IMMUNE RESPONSE TO THE HIGHLY CONSERVED STALK DOMAIN BY CONTROLLING THE ORIENTATION OF HA, AND MULTIVALENT PRESENTATION, WILL PROVIDE BROAD, DURABLE, AND ROBUST PROTECTION AGAINST GROUP 1 INFLUENZA A VIRUSES. INFLUENZA REPRESENTS A SERIOUS GLOBAL HEALTH PROBLEM, WITH SEASONAL INFLUENZA VIRUS INFECTIONS IMPOSING SIGNIFICANT HEALTH AND ECONOMIC BURDENS, AND PANDEMICS CAUSED BY NOVEL INFLUENZA VIRUSES REPRESENTING AN EVEN MORE SERIOUS THREAT. LICENSED VACCINES INDUCE AN IMMUNE RESPONSE THAT PRIMARILY TARGETS THE HEAD DOMAIN OF HA, WHICH IS HIGHLY VARIABLE IN SEQUENCE. AS A RESULT, THE IMMUNE RESPONSE TO INFLUENZA VACCINATION IS NARROW AND STRAIN-SPECIFIC AND WOULD PROVIDE LITTLE PROTECTION AGAINST POTENTIAL PANDEMIC INFLUENZA VIRUSES. WHILE “BROADLY NEUTRALIZING” ANTIBODIES TARGETING THE HIGHLY CONSERVED STALK DOMAIN OF HA ARE PROPHYLACTICALLY AND THERAPEUTICALLY PROTECTIVE AGAINST INFLUENZA VIRUS CHALLENGES IN VIVO, SUCH ANTIBODIES ARE NOT ELICITED EFFECTIVELY IN NATURAL INFECTIONS OR BY LICENSED INFLUENZA VACCINES. THE IMMUNOSUBDOMINANCE OF THE HA STALK DOMAIN MAY RESULT FROM ITS MEMBRANE-PROXIMAL LOCATION, WITH INTERACTIONS OF B-CELL RECEPTORS WITH CONSERVED STALK EPITOPES BEING BLOCKED BY STERIC HINDRANCE ON VIRIONS WHICH ARE DENSELY PACKED WITH GLYCOPROTEINS. INDEED, WE HAVE RECENTLY SHOWN THAT TUNING THE ORIENTATION OF HA TO ENHANCE THE ACCESSIBILITY OF STALK EPITOPES RESULTS IN AN ENHANCED PROTECTIVE STALK-DIRECTED IMMUNE RESPONSE. FURTHERMORE, WE HAVE DEMONSTRATED AN APPROACH (TETHERED ANTIGENIC SUPPRESSION) FOR SUPPRESSING THE IMMUNE RESPONSE TO THE HEAD DOMAIN OF HA AND REFOCUSING THE IMMUNE RESPONSE ON DESIRED EPITOPES (SUCH AS THE STALK). WE HAVE ALSO DESIGNED VACCINES THAT ELICIT A ROBUST PROTECTIVE ANTIBODY RESPONSE AGAINST A VARIETY OF ANTIGENS, INCLUDING HA, BY DISPLAYING THEM MULTIVALENTLY FROM VIRUS-LIKE PARTICLES. THE FIRST AIM OF THE PROPOSED WORK IS TO ENGINEER AND TEST NOVEL HA ANTIGEN DESIGNS TO PROVIDE AN ENHANCED STALK- DIRECTED IMMUNE RESPONSE. WE WILL SHIELD THE HEAD DOMAIN OF HA TO SUPPRESS ITS IMMUNOGENICITY AND WILL TUNE THE ORIENTATION OF THE HEAD-SHIELDED HA TO INCREASE THE ACCESSIBILITY OF THE STALK DOMAIN AND ENHANCE ITS IMMUNOGENICITY. WE WILL ALSO INVESTIGATE THE ABILITY TO FURTHER INCREASE THE BREADTH OF PROTECTION BY USING ENGINEERED HA ANTIGENS THAT INCORPORATE STALK DOMAINS FROM DIFFERENT VIRAL SUBTYPES. THE SECOND AIM IS TO CHARACTERIZE THE BREADTH AND THE LONGEVITY OF THE ANTI-STALK RESPONSE INDUCED BY VACCINATION IN MICE. THE THIRD AIM IS TO CHARACTERIZE IMMUNOGENICITY AND VACCINE EFFICACY IN NAÏVE AND PRE-IMMUNIZED, MALE AND FEMALE FERRETS.

SOUTHEASTERN TAAC

EFFECT OF PRESENTATION METHODS ON THE MOLECULAR MECHANISM OF COMBINATORIAL ADJUVANTS

NEW START GRANT

RERC ON SUPPORTIVE TECHNOLOGIES FOR SUCCESSFUL AGING WITH DISABILITY (RERC TECHSAGE)

ACOUSTIC IMAGING OF SENTINEL NODE METASTASIS USING PLASMONIC NANOSENSORS

IDENTIFYING MULTI-SCALE MECHANISMS FOR AGE-RELATED INCREASE IN METABOLIC COST OF WALKING - MOBILITY SERVES AS A SURROGATE FOR WELL-BEING WITH AGE-RELATED LIMITS TO WALKING FUNCTION THAT INCLUDE: INCREASED ENERGY COST AND DECREASED SPEED. IN 2021, THE NATIONAL INSTITUTE ON AGING CONVENED INTERDISCIPLINARY SCIENTISTS TO IDENTIFY MULTI-SCALE MECHANISMS FOR MOBILITY IMPAIRMENTS IN AGING AND IDENTIFIED MULTIPLE FACTORS CONTRIBUTING TO ELEVATED METABOLIC COST AND REDUCED WALKING SPEED. A FOUNDATIONAL AGE-RELATED DIFFERENCE IN WALKING FUNCTION EMERGED - THE SO CALLED ‘DISTAL TO PROXIMAL SHIFT’ IN NEUROMECHANICAL EFFORT. OLDER WALKERS RELY MORE ON PROXIMAL HIP RATHER THAN DISTAL ANKLE MUSCLE-TENDONS TO POWER GAIT. THIS PROPOSAL LEVERAGES A MULTI-SCALE, COMPUTATIONAL-EXPERIMENTAL APPROACH TO PROBE CELLULAR-TO-BEHAVIORAL MECHANISMS LINKING THE ‘DISTAL-TO PROXIMAL’ SHIFT TO INCREASED ENERGY COST AND DECREASED WALKING SPEED WITH AGE. THE CENTRAL HYPOTHESIS IS THAT OLDER ADULTS SELECT SLOWER GAIT SPEEDS TO PRIORITIZE STABILITY OVER ECONOMY, AND THESE ‘SAFER’, PROXIMALLY- BIASED GAITS COMBINE WITH DECLINES IN NEUROMUSCULAR EFFICIENCY CREATING A ‘LOSE-LOSE’ COMBINATION THAT ELEVATES THE METABOLIC COST OF WALKING. AIM 1: CHARACTERIZE AGE-RELATED DIFFERENCES IN THE RELATIONSHIP BETWEEN LOWER-LIMB JOINT MECHANICS AND METABOLIC COST OF ‘ECOLOGICALLY-RELEVANT’ WALKING. APPROACH: GATECH WILL RECRUIT N=60 [N=30 (15M/15F) YOUNG ADULTS (YA) 18 – 30Y AND N=30 (15M/15F) OLDER ADULTS (OA-SED) ≥60Y]. OUTCOMES: NET METABOLIC POWER, LOWER-LIMB MUSCLE ACTIVITY AND JOINT KINEMATICS/KINETICS DURING ‘ECOLOGICALLY-RELEVANT’ OUTDOOR WALKING WITH A NOVEL SENSOR SUIT USING CUSTOM-TRAINED MACHINE-LEARNING ALGORITHMS. ANKLE AND HIP EXOSKELETONS TO PROBE JOINT-LEVEL MECHANICAL EFFICIENCY. EXPECTED RESULTS: OA-SED>YA NET METABOLIC POWER ASSOCIATED WITH HIGHER, MORE PROXIMAL AND LESS EFFICIENT LOWER-LIMB JOINT POWER. AIM 2: EXAMINE HOW AGE-RELATED CHANGES IN PROXIMAL-TO-DISTAL MUSCULOTENDON STRUCTURE AND CELLULAR/MOLECULAR MUSCLE FUNCTION IMPACT METABOLIC COST OF WALKING. APPROACH: IHMC WILL RECRUIT YA+OA-SED (SAME AS AIM 2) PLUS N=30 (15M/15F) ≥60Y PHYSICALLY ACTIVITY OA (OA-FIT). OUTCOMES: TREADMILL OUTCOMES FROM AIM 2, DISTAL-TO-PROXIMAL MUSCULOTENDON PROFILING, LATERAL GASTROCNEMIUS (DISTAL) AND VASTUS LATERALIS (PROXIMAL) MUSCLE BIOPSIES FOR MITOCHONDRIAL FUNCTION, MYOFIBER TYPE/SIZE/GROUPING, TARGETED MITOCHONDRIAL/METABOLIC MOLECULAR ANALYSES. EXPECTED RESULTS: OA-SED < OA-FIT <YA NET METABOLIC POWER ASSOCIATED WITH PROXIMALLY-BIASED REDUCTIONS IN MUSCLE FORCE CAPACITY/MITOCHONDRIAL FUNCTION. AIM 3: DETERMINE THE INFLUENCE OF TASK-LEVEL PRIORITIES ON OBSERVED AGE-RELATED INCREASES IN METABOLIC COST OF WALKING. APPROACH: PREDICTIVE MUSCULOSKELETAL SIMULATIONS THAT SATISFY A PRE-DEFINED WALKING ENERGY- STABILITY CRITERION. OUTCOMES: PREDICTED LOWER-LIMB MUSCLE ACTIVATIONS, JOINT AND MUSCULOTENDON KINEMATICS AND KINETICS, AND METABOLIC ENERGY COST OF WALKING FOR SIMULATIONS WITH OLD VS. YOUNG. EXPECTED RESULTS. DATA-DRIVEN SIMULATIONS WILL MATCH EXPERIMENTAL MUSCLE ACTIVATIONS FROM AIMS1+2. IMPACT: COMPUTATIONAL-EXPERIMENTAL APPROACH IDENTIFIES KEY AGE-RELATED DIFFERENCES IN MUSCLE BIOLOGY, MUSCULOTENDON STRUCTURE-FUNCTION, JOINT-LEVEL MECHANICS AND TASK-LEVEL PRIORITIZATION THAT DRIVE ELEVATED METABOLIC COST OF WALKING IN AGING.

INVESTIGATION OF ELECTROMAGNETIC INDUCTION SENSORS; RESEARCH AREA 2.1 TERRESTRIAL SCIENCES, DR. RUSSELL HARMON

SOLAR, INSTALL, MOUNT, PRODUCTION, LABOR, EQUIPMENT (SIMPLE BOS)

REAL-TIME IN VIVO IVUS/IVPA IMAGING TO DETECT AND CHARACTERIZE VULNERABLE PLAQUES

EXPLORATION OF NEW CHEMISTRIES AND PROCESSES FOR ADDITIVE MANUFACTURING OF CERAMICS

FELLOWSHIP AND SCHOLARSHIP SUPPORT

REHABILITATION ENGINEERING RESEARCH CENTERS

COLLABORATIVE RESEARCH: SPECIAL PROJECTS (CNS): BPC-A: EXPANDING COMPUTING EDUCATION PATHWAYS (ECEP) ALLIANCE

NEW; GUIDED ASSEMBLY OF ANISOTROPIC MICRO-STRUCTURES INTO MESOSCALE HIERARCHIES; PI - VLADIMIR V. TSUKRUK

NNCI COORDINATING OFFICE AT GEORGIA TECH

OSSEO-REPARATIVE, INTEGRIN-SPECIFIC MATERIALS

KINETIC MECHANICAL PROPERTIES OF ALB2 INTEGRIN

(MURI 03) ACTIVE-VISION CONTROL SYSTEMS FOR COMPLEX ADVERSARIAL 3-D ENVIRONMENTS, DATED 19 NOV 02; THE TERMS AND CONDITIONS OF THE FDP, 1 OCTOBER 200

MULTIMODAL MULTIPLEXED INTEGRATED PHOTONIC SENSORS FOR CHEMICAL AND BIOLOGICAL SENSING

GAME THEORETIC LEARNING FOR DISTRIBUTED AUTONOMOUS COLLABORATION

IDEAS LAB: CFIRE: META-PURE: END-USE-DRIVEN CELL-FREE MODULES -META-PURE: END-USE-DRIVEN CELL-FREE MODULES CELL-FREE SYSTEMS REDUCE BIOLOGY TO ITS MOST BASIC PARTS, SIMPLIFYING THE COMPLEXITY OF TRADITIONAL BIOMANUFACTURING. HOWEVER, SCIENTISTS STILL DO NOT HAVE AN EFFICIENT WAY TO ?PLUG-AND-PLAY? THESE INDIVIDUAL CELL-FREE PIECES. THIS PROJECT ADDRESSES THIS GAP BY DEVELOPING A MODULAR, STANDARDIZED PLATFORM FOR CELL-FREE BIOPROCESSING. INSTEAD OF CUSTOM, ONE-OFF DESIGNS, THE PROJECT CREATES EIGHT REUSABLE MODULES COVERING ESSENTIAL FUNCTIONS LIKE ENERGY GENERATION AND PROTEIN EXPRESSION. THESE ?READY-TO-USE? MODULES MAKE IT EASIER TO MIX AND MATCH CAPABILITIES, ALLOWING FOR FASTER, MORE EFFICIENT PRODUCT DEVELOPMENT. THE TEAM WILL DEMONSTRATE HOW MODULAR DESIGN AND STANDARDIZED KITS CAN REDUCE COSTS, IMPROVE ACCESSIBILITY, AND BOOST PRODUCTIVITY ACROSS THREE MARKET-RELEVANT TARGETS. IN DOING SO, THIS PROJECT AIMS TO MAKE CELL-FREE TECHNOLOGIES BROADLY AVAILABLE AND EXPAND THE USE OF CELL-FREE TECHNOLOGIES ACROSS THE U.S. BIOECONOMY. THIS PROJECT WILL ALSO CULTIVATE THE NEXT GENERATION OF BIOTECHNOLOGY TALENT THROUGH A DYNAMIC, CROSS-SECTOR TEAM OF POSTDOCS AND GRADUATE STUDENTS?UNITING EXPERTISE FROM INDUSTRY, ACADEMIA, AND GOVERNMENT?TO PIONEER AND SCALE THE FUTURE OF CELL-FREE BIOMANUFACTURING. THE PROJECT PIONEERS A MODULAR, STANDARDIZED FRAMEWORK TO ADDRESS BOTTLENECKS FOR SCALING CELL-FREE BIOPROCESSING. THE PROJECT WILL DEVELOP, CHARACTERIZE, AND INTEGRATE EIGHT DISTINCT FUNCTIONAL MODULES COMMON ACROSS CELL-FREE SYSTEMS: THREE FOR ENERGY GENERATION, THREE FOR THE SYNTHESIS OF VALUABLE PRODUCTS, AND TWO FOR TRANSCRIPTION?TRANSLATION. THESE MODULES SPAN VARYING LEVELS OF COMPLEXITY?FROM INDIVIDUAL PURIFIED ENZYMES TO ENZYME CASCADES, PURIFIED RECOMBINANT ELEMENTS (PURE), AND LYSATE-BASED SYSTEMS?ENCOMPASSING THE FULL SPECTRUM OF CELL-FREE BIOTECHNOLOGIES. THIS MODULARITY ALLOWS INNOVATION BEYOND STANDALONE PURE TECHNOLOGIES; IT COMPRISES MODULES WITH DEFINED CAPABILITIES, EACH BUILT AND OPTIMIZED INDEPENDENTLY, THEN INTEGRATED TO ACHIEVE MORE COMPLEX AND AMBITIOUS SYNTHESIS GOALS. THE PROJECT ALSO INCORPORATES ADVANCED ANALYTICAL TOOLS AND ESTABLISHES NEW STANDARDS AND METRICS TO RIGOROUSLY EVALUATE MODULE PERFORMANCE AND COMPATIBILITY, WHICH WILL RESULT IN A SYSTEM THAT PROVIDES RELIABLE SYNTHESIS. FURTHER, THE SYSTEM WILL BE VALIDATED THROUGH THE SYNTHESIS OF THREE INDUSTRIALLY RELEVANT TARGETS: THE VALUABLE SMALL MOLECULE SANTALENE; THE GAMS PROTEIN, WHICH ENHANCES CELL-FREE PROTEIN EXPRESSION; AND PRODUCTION OF A BACTERIOPHAGE. THESE DEMONSTRATIONS WILL SHOW HOW THE SYSTEM CAN BE USED FOR A VARIED OF USE CASES. THIS PROJECT WILL ACCELERATE INNOVATION, ENHANCE REPRODUCIBILITY, AND DEMONSTRATE A REPLICABLE FRAMEWORK THAT ENABLES FLEXIBLE, COST-EFFECTIVE, AND HIGH-PERFORMANCE BIO-BASED PRODUCTION PLATFORMS ACROSS DIVERSE APPLICATIONS TO SUPPORT SCALABLE BIOMANUFACTURING AND STRENGTHEN THE INFRASTRUCTURE OF THE U.S. BIOECONOMY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

DE-FE-0007804 GEORGIA TECH RESEARCH CORPORATION PROJECT TITLED: RAPID-TEMPERATURE SWING ADSORPTION USING POLYMERIC/SUPPORTED AMINE HOLLOW FIBER MATE

EARSKETCH: AN AUTHENTIC, STUDIO-BASED STEAM APPROACH TO HIGH SCHOOL COMPUTING EDUCATION

DEVELOPMENT AND VALIDATION OF A NEW GENERALIZED FRAMEWORK FOR OBJECTIVE RAPID EXPLORATIONS OF DESIGN SPACES FOR NOVEL ENGINEERED MATERIALS

PHYSICS-AWARE AND AUTOMATED VULNERABILITY DISCOVERY AND PATCHING IN HETEROGENEOUS DISTRIBUTED ENERGY RESOURCES AGAINST CYBER ATTACKS DEVELOP AND DEMONSTRATE DERGUARD, AN AUTOMATED DISTRIBUTED ENERGY RESOURCE (DER) DEVICE SECURITY VETTING AND HARDENING FRAMEWORK. DEVELOP TECHNIQUES TO ANALYZE INDIVIDUAL DISTRIBUTED ENERGY RESOURCE (DER) DEVICES AND THEIR FUNCTIONAL BENIGN AND POTENTIALLY MALICIOUS IMPACT ON SYSTEM-WIDE POWER GRID OPERATIONS.

GRIDLOGIC: HARDWARE/SOFTWARE CODESIGN FOR DEEP GRID VISIBILITY AND SECURITY PROPOSE GRIDLOGIC, A FRAMEWORK FOR CYBER-PHYSICAL SECURITY BY DESIGN THAT WILL IMPEDE ATTACKERS OR MALICIOUS OPERATORS FROM TAKING ACTIONS THAT ARE DETRIMENTAL TO THE ELECTRICITY GRID. THE PROJECT HAS THE FOLLOWING OBJECTIVES: DEVELOP AND IMPLEMENT A CONTROL SYSTEM CAPABLE OF BLOCKING DETRIMENTAL ACTIONS OR TRAJECTORY OPERATIONAL ACTION BY AN EXTERNAL ATTACKER AND EVEN IN THE CASE OF AN AUTHORIZED INSIDER, IMPLEMENT AND DEMONSTRATE HARDWARE-BASED DATA ENCRYPTION AS A SECOND LAYER (I.E., IN ADDITION TO ANY NETWORK-BASED ENCRYPTION) FOR FIELD CONTROL DEVICES, DEVELOP AND DEMONSTRATE DEEP COMMUNICATION NETWORK CAPABILITY WITH ANOMALY DETECTION, AND DEVELOP AND DEMONSTRATE AI-BASED, SYSTEM-LEVEL CYBER-PHYSICAL SECURITY ASSESSMENT.

NRT-FW-HTF: NSF TRAINEESHIP IN THE SUSTAINABLE DEVELOPMENT OF SMART MEDICAL DEVICES -EXISTING MEDICAL DEVICES DESIGNED FOR WIDESPREAD USE IN DAILY LIFE INTRODUCE AN ASSOCIATED CHALLENGE OF ENVIRONMENTAL IMPACT, PARTICULARLY REGARDING MATERIAL WASTE AND CARBON EMISSIONS FROM THE PRODUCTION CYCLE. RECENT ADVANCEMENTS IN ELECTRONIC TECHNOLOGIES EXPEDITE THE PRODUCTION OF A SIGNIFICANTLY HIGHER VOLUME OF NEW MEDICAL DEVICES. ADDRESSING SUSTAINABILITY ISSUES NECESSITATES A COLLABORATIVE, MULTIDISCIPLINARY APPROACH AND A CONCERTED EFFORT TO TRAIN THE NEXT GENERATION OF DESIGNERS AND ENGINEERS TO PRIORITIZE SUSTAINABILITY AND INNOVATION. THIS NATIONAL SCIENCE FOUNDATION RESEARCH TRAINEESHIP AWARD TO THE GEORGIA INSTITUTE OF TECHNOLOGY WILL ADDRESS THIS NEED BY TRAINING MASTER'S AND DOCTORAL STUDENTS IN ADVANCED SUSTAINABLE MEDICAL DEVICES THAT ARE BOTH TECHNOLOGICALLY SOPHISTICATED AND ENVIRONMENTALLY RESPONSIBLE, OFFERING TRAITS LIKE REUSABILITY AND RELIABILITY, THUS FULFILLING A CRUCIAL NATIONAL PRIORITY. THE TRAINEESHIP EXPECTS TO PROVIDE A UNIQUE AND COMPREHENSIVE TRAINING OPPORTUNITY FOR ONE HUNDRED (100) STUDENTS, INCLUDING TWENTY-FIVE (25) FUNDED TRAINEES, BY COMBINING MULTIPLE DISCIPLINES IN MEDICAL DEVICES, SUSTAINABLE DESIGN, AND MANUFACTURING PRINCIPLES; COLLABORATIONS WITH CLINICAL PARTNERS AND ACCELERATORS; HANDS-ON EXPERIENCES WITH HEALTH-RELATED RESEARCH; AND A CULTURE OF INNOVATIVE AND TRANSLATIONAL RESEARCH. TRAINEES WILL LEARN ABOUT A BROAD SPECTRUM OF DISCIPLINES, INCLUDING BIOENGINEERING, PUBLIC POLICY, PHYSIOLOGY, INDUSTRIAL DESIGN, INTERACTIVE COMPUTING, AND MEDICINE. BY BRIDGING THE GAP THAT CURRENTLY EXISTS BETWEEN SUSTAINABILITY, DEVICE TECHNOLOGY, BIODEGRADABILITY, AND MEDICAL SCIENCE, THE TRAINEESHIP WILL ADDRESS THE LACK OF A FRAMEWORK TO FACILITATE INTERDISCIPLINARY COLLABORATION AMONG ENGINEERS, SCIENTISTS, DESIGNERS, POLICY-MAKERS, AND CLINICIANS. THE TRAINEESHIP?S MAJOR GOAL IS TO DEVELOP A MULTIDISCIPLINARY CURRICULUM THAT COMBINES METHODS FROM VARIOUS DOMAINS TO RESOLVE ONGOING CHALLENGES IN DEVELOPING RELIABLE AND PERSONALIZED MEDICAL DEVICES FOR HEALTHCARE. IN PARTNERSHIP WITH CLINICAL EXPERTS AND MEDICAL PRODUCT ACCELERATORS, THE INITIATIVE WILL BROADEN STUDENTS' PERSPECTIVES BEYOND THE CURRENT TECHNOLOGY-FIRST MINDSET AND REFLECT THE NEEDS OF PATIENTS AND HEALTHCARE PROVIDERS THROUGH SUSTAINABLE TECHNOLOGICAL SOLUTIONS. ANOTHER GOAL OF THE TRAINEESHIP IS TO ATTRACT A MORE DIVERSE GROUP OF STUDENTS TO THE INTERDISCIPLINARY FIELD OF HEALTHCARE TECHNOLOGIES AND CONTRIBUTE TO PROMOTING DIVERSITY IN WORKFORCE DEVELOPMENT. THE PROJECT WILL DEVELOP A NEW PH.D. CONCENTRATION AREA IN SMART MEDICAL DEVICES WITHIN THE BIOENGINEERING PROGRAM AND A NEW M.S. DEGREE PROGRAM IN THE SUSTAINABLE DEVELOPMENT OF MEDICAL DEVICES EMBEDDED IN THE COLLEGES OF ENGINEERING, SCIENCE, AND DESIGN. CURRICULUM MATERIALS AND BEST PRACTICES WILL BE DISSEMINATED FOR OTHER INSTITUTIONS TO EMULATE. THE NSF RESEARCH TRAINEESHIP (NRT) PROGRAM IS DESIGNED TO ENCOURAGE THE DEVELOPMENT AND IMPLEMENTATION OF BOLD, NEW POTENTIALLY TRANSFORMATIVE MODELS FOR STEM GRADUATE EDUCATION TRAINING. THE PROGRAM IS DEDICATED TO EFFECTIVE TRAINING OF STEM GRADUATE STUDENTS IN HIGH PRIORITY INTERDISCIPLINARY OR CONVERGENT RESEARCH AREAS THROUGH COMPREHENSIVE TRAINEESHIP MODELS THAT ARE INNOVATIVE, EVIDENCE-BASED, AND ALIGNED WITH CHANGING WORKFORCE AND RESEARCH NEEDS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

FMRG: MANUFACTURING USA: CYBER: DATA-DRIVEN METHODS FOR FUTURE CYBER MANUFACTURING AS A SERVICE -CYBER MANUFACTURING ANTICIPATES A NETWORKED SERVICE FOR ON-DEMAND MANUFACTURING OF ENGINEERED PARTS AND PRODUCTS. SUCH A SERVICE HAS THE POTENTIAL TO DEMOCRATIZE ACCESS TO THE MEANS AND KNOW-HOW OF DISCRETE PARTS MANUFACTURING AT THE REDUCED TIME, SCALE, AND COST. ADVANCES IN DIGITAL DESIGN, LOW-COST SENSING, AND NETWORKED MANUFACTURING MACHINES HAVE POTENTIAL TO ENABLE READY ACCESS TO THE MEANS OF PRODUCTION, ALONG WITH DESIGN AND PRODUCTION DATA. HOWEVER, COMPUTATIONAL METHODS AND TOOLS THAT ENABLE A FUTURE CYBER MANUFACTURING SERVICE TO AUTOMATICALLY TRANSLATE A DIGITAL DESIGN INTO A MANUFACTURED PRODUCT USING THE AVAILABLE MEANS OF PRODUCTION ARE NEEDED. THIS AWARD SUPPORTS FUNDAMENTAL RESEARCH TO AUTOMATE THE SELECTION, PLANNING AND ACQUISITION OF THE MANUFACTURING PROCESSES AND RESOURCES REQUIRED TO PRODUCE DISCRETE PARTS AND PRODUCTS ON-DEMAND. THIS CAPABILITY IS APPLICABLE TO A WIDE RANGE OF MANUFACTURING INDUSTRIES INCLUDING AEROSPACE, AUTOMOTIVE, ENERGY, AND BIOMEDICAL. THEREFORE, THIS RESEARCH WILL BENEFIT THE COMPETITIVENESS OF THE U.S. MANUFACTURING SECTOR AND SOCIETY. THE RESEARCH INTEGRATES SEVERAL DISCIPLINES INCLUDING DESIGN, MANUFACTURING SCIENCE AND TECHNOLOGY, HUMAN-COMPUTER INTERACTION, ARTIFICIAL INTELLIGENCE, AND MACHINE LEARNING. THROUGH PARTNERSHIP WITH A HISPANIC SERVING INSTITUTION, INDUSTRY, A MANUFACTURING USA INSTITUTE, AND OUTREACH TO OTHER UNDERREPRESENTED COMMUNITIES, THE PROJECT WILL EDUCATE AND TRAIN A DIVERSE FUTURE CYBER MANUFACTURING WORKFORCE. THIS PROJECT WILL RESEARCH A DATA-DRIVEN COMPUTATIONAL FRAMEWORK THAT ENABLES COMPUTERS TO INFER DESIGN ELEMENTS AND PROCESSING DETAILS FOR NEW PARTS FROM THE ACCUMULATED DESIGN AND PRODUCTION EXPERIENCE OF INDUSTRY WITH PARTS THAT HAVE BEEN MANUFACTURED PREVIOUSLY. THIS CAPABILITY RESTS ON EXTRACTING CORE MANUFACTURING INTELLIGENCE IN THE FORM OF SCALABLE AND GENERATIVE MANUFACTURING PROCESS CAPABILITY KNOWLEDGE AND DESIGN-FOR-MANUFACTURING KNOWLEDGE FROM PAST AND CURRENT DESIGN AND MANUFACTURING DATA. SPECIFICALLY, THE RESEARCH WILL YIELD FUNDAMENTAL KNOWLEDGE OF THE GENERATIVE CAPABILITY OF MANUFACTURING PROCESSES TO TRANSFORM PART SHAPE, MATERIAL PROPERTIES, AND QUALITY TO MEET PRODUCT DESIGN REQUIREMENTS, AND GENERATIVE REDESIGN-FOR-FUNCTIONALITY AND MANUFACTURABILITY. PROCESS PLANNING AND PART REDESIGN METHODS WILL BE DEVELOPED FROM A COMBINATION OF NEW DEEP LEARNING, SHAPE DESCRIPTOR, AND MANUFACTURING REASONING TECHNOLOGIES. THE RESULTING DATA-DRIVEN COMPUTATIONAL FRAMEWORK WILL PROVIDE THE FUNDAMENTAL SOFTWARE TOOLS TO IMPLEMENT FUTURE CYBER MANUFACTURING SERVICES THAT PROVIDE A SCALABLE AND EFFICIENT SOLUTION FOR AUTOMATICALLY TRANSLATING DIGITAL DESIGNS INTO PHYSICAL PRODUCTS ON-DEMAND. THIS FUTURE MANUFACTURING AWARD WAS SUPPORTED BY THE OFFICE OF THE ASSISTANT DIRECTOR (OAD) AND THE DIVISION OF CIVIL, MECHANICAL AND MANUFACTURING INNOVATION (CMMI) OF THE DIRECTORATE FOR ENGINEERING (ENG), THE DIVISION OF UNDERGRADUATE EDUCATION (DUE) OF THE DIRECTORATE FOR EDUCATION AND HUMAN RESOURCES (EHR) AND THE DIVISION OF COMPUTER AND NETWORK SYSTEMS (CNS) OF THE DIRECTORATE FOR COMPUTER AND INFORMATION SCIENCE AND ENGINEERING (CISE). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

NETSE:LARGE: MONACO: FUNDAMENTALS OF MOLECULAR NANO-COMMUNICATION NETWORKS

RIPS TYPE 2: PARTICIPATORY MODELING OF COMPLEX URBAN INFRASTRUCTURE SYSTEMS (MODEL URBAN SYSTEMS)

IMPLICATIONS OF INHERENT HETEROGENEITIES AND TAILORED STRUCTURAL CONFIGURATIONS ON HIGH STRAIN RATE MECHANICAL RESPONSE AND CHEMICAL REACTIVITY OF AD

IGERT: NANOSTRUCTURED MATERIALS FOR ENERGY STORAGE AND CONVERSION

AN INNOVATIVE APPROACH TO PRECISION FISSION MEASUREMENTS USING A TIME PROJECTION CHAMBER

NETWORK PERFORMANCE MONITORING & DISTRIBUTED SIMULATION TO IMPROVE TRANSPORTATION ENERGY EFFICIENCY

DEEP OVARIAN CANCER METABOLOMICS

UNDERSTANDING MECHANISMS OF FONTAN FAILURE AND KEY PREDICTORS FOR PATIENT OUTCOME

TRIMODAL VITALITY IMAGING OF NEURAL PROGENITOR CELLS IN THE SPINAL CORD

STUDENTS AND TEACHERS LEARNING FROM NATURE: STUDYING BIOLOGICALLY-INSPIRED DESIGN IN HIGH SCHOOL ENGINEERING EDUCATION

ARTEMIS QUARC - QUALITY UNDER ADJUSTABLE REALISTIC CONDITIONS

MICRONEEDLE-BASED IMMUNIZATION AGAINST PANDEMIC INFLUENZA

NRT: ACCESSIBILITY, REHABILITATION, AND MOVEMENT SCIENCE (ARMS): AN INTERDISCIPLINARY TRAINEESHIP PROGRAM IN HUMAN-CENTERED ROBOTICS

MICROFLUIDIC TISSUE ENGINEERING OF SMALL AIRWAY INJURIES

FUNDING OPPORTUNITY NUMBER: HR001123S0051CATALOG OF FEDERAL DOMESTIC ASSISTANCE (CFDA) NUMBER(S): 12.910 RESEARCH AND TECHNOLOGY DEVELOPMENTTHE 80 YEAR OLD CHALLENGE OF TURNING ALN INTO A SEMICONDUCTOR HAD SEEN VERY LITTLE PROGRESS UNTIL 2021 WHEN GA TECH SUCCESSFULLY DEMONSTRATED P-TYPE ALN WITH HOLE CONCENTRATIONS EXCEEDING 3X1018 CM-3 1. IN LESS THAN TWO YEARS, BOTH P-TYPE AND N-TYPE CARRIER CONCENTRATIONS GREATER THAN 4.4-6.1 X 1018 CM-3 WERE SUBSEQUENTLY ACHIEVED2,3. THESE CARRIER CONCENTRATIONS ARE SUFFICIENTLY HIGH TO ALLOW REASONABLE OHMIC CONTACTS, ALBEIT WITH APPROACHES THAT CURRENTLY HAVE NO CORRESPONDING THEORY TO EXPLAIN THEIR LIMITED SUCCESS. THESE ADVANCES HAVE RESULTED IN BOTH PN DIODES WITH 3 A CM2 AND TRANSISTOR STRUCTURES WITH 357 A MM AND 37 A MM CURRENT DENSITIES FOR N-TYPE AND P-TYPE MESFETS, RESPECTIVELY. AS PROMISING AS THESE EARLY RESULTS HAVE BEEN, THEY FALL SHORT OF THE CONTACT RESISTANCES NEEDED FOR STATE-OF-THE-ART DEVICES AND HAVE COME WITH LIMITED THEORETICAL AND CHARACTERIZATION UNDERSTANDING. THIS MUST BE RECTIFIED IF THE FIELD IS GOING TO MOVE FORWARD. GIVEN 1) ALN HAS EXCEPTIONAL PROPERTIES FOR ELECTRONICS INCLUDING EXCELLENT THERMAL CONDUCTIVITY, A SATURATION VELOCITY ALMOST (93%) AS HIGH AS THAT OF GAN, BUT CRITICAL ELECTRIC FIELDS FOR BREAKDOWN WHICH ARE 3-5X THAT OF GAN AND SIC (ATTRIBUTABLE TO IT HAVING THE LARGEST BANDGAP (6.1 EV) OF ANY SEMICONDUCTOR) WITH A 2) COMMERCIALLY AVAILABLE 2 SUBSTRATE AND 4 RESEARCH SCALE SUBSTRATE ALREADY AVAILABLE AND 3) ENORMOUS OPTOELECTRONICS MARKETS THAT CAN EXPEDITE THE ECOSYSTEM NEEDED FOR WIDESPREAD ADOPTION (AS PREVIOUSLY WAS THE CASE FOR GAAS, INP, AND GAN), IT IS NOT A STRETCH TO ENVISAGE ALN BEING THE NEXT REVOLUTION IN ELECTRONICS. TO ENABLE THIS PREDICTION, A NEW NITRIDE ERA (ANNE) TEAM HAS BEEN ASSEMBLED AS DESCRIBED IN FIGURE 1 TO ADVANCE THE STATE OF THE ART IN: 1) EPITAXY CAPABLE OF HIGH N- AND P-TYPE CARRIER CONCENTRATIONS, 2) STATE OF THE ART CHARACTERIZATION, 3) MATERIALS MODELING, 4) ADVANCED DEVICE THERMAL, ELECTRICAL MODELING AND 5) FABRICATION WITH 6) NOVEL NEW CONTACT CHEMISTRY AND CONCEPTS. EACH OF THESE TECHNOLOGIES WILL BE USED TO LEVERAGE ALL THREE ASPECTS OF DIODE DESIGN TO EXCEED THE DARPA UWBGS DIODE METRICS: A) THE METAL-SEMICONDUCTOR INTERFACE, B) THE BULK OF THE SEMICONDUCTOR AND C) DEVICE DESIGN AND IMPLEMENTATION. TO IMPACT A NEW ERA OF DOD ELECTRONICS, INDUSTRY PARTNERS MUST BE INVOLVED, AND TECHNOLOGY TRANSITIONED SWIFTLY TO ENABLE ADVANCED DEVICES AND IMPACT EVALUATIONS. FOR THIS REASON, WE HAVE PARTNERED WITH RTX (FORMERLY RAYTHEON) TO ENSURE RAPID AND RELEVANT TECHNOLOGY TRANSITION FOR NEAR TERM IMPACT ON DOD MISSIONS.

SUPERHYDROPHOBIC HEART VALVE PROSTHESIS

NON-INVASIVE BIOSENSORS TO DETECT CARDIOVASCULAR CHANGES IN HEART FAILURE

USING DIRECTED EVOLUTION TO STUDY THE ORIGINS OF MULTICELLULAR DEVELOPMENT.

TO OBTAIN A COPY OF THE FUNDING OPPORTUNITY ANNOUNCEMENT (FOA) PLEASE GO TO THE ARPA-E WEBSITE AT HTTPS://ARPA-E-FOA.ENERGY.GOV. TO APPLY TO THIS FOA, APPLICANTS MUST REGISTER WITH AND SUBMIT APPLICATION MATERIALS THROUGH ARPA-E EXCHANGE (HTTPS://ARPA-E-FOA.ENERGY.GOV/REGISTRATION.ASPX). FOR DETAILED GUIDANCE ON USING ARPA-E EXCHANGE, PLEASE REFER TO THE ARPA-E EXCHANGE USER GUIDE (HTTPS://ARPA-E-FOA.ENERGY.GOV/MANUALS.ASPX). ARPA-E WILL NOT REVIEW OR CONSIDER CONCEPT PAPERS SUBMITTED THROUGH OTHER MEANS. FOR PROBLEMS WITH ARPA-E EXCHANGE, EMAIL EXCHANGEHELP@HQ.DOE.GOV (WITH FOA NAME AND NUMBER IN THE SUBJECT LINE). QUESTIONS ABOUT THIS FOA? CHECK THE FREQUENTLY ASKED QUESTIONS AVAILABLE AT HTTP://ARPA-E.ENERGY.GOV/FAQ. FOR QUESTIONS THAT HAVE NOT ALREADY BEEN ANSWERED, EMAIL ARPA-E-CO@HQ.DOE.GOV. AGENCY OVERVIEW THE ADVANCED RESEARCH PROJECTS AGENCY – ENERGY (ARPA-E), AN ORGANIZATION WITHIN THE DEPARTMENT OF ENERGY (DOE), IS CHARTERED BY CONGRESS IN THE AMERICA COMPETES ACT OF 2007 (P.L. 110-69), AS AMENDED BY THE AMERICA COMPETES REAUTHORIZATION ACT OF 2010 (P.L. 111-358), AS FURTHER AMENDED BY THE ENERGY ACT OF 2020 (P.L. 116-260): “(A) TO ENHANCE THE ECONOMIC AND ENERGY SECURITY OF THE UNITED STATES THROUGH THE DEVELOPMENT OF ENERGY TECHNOLOGIES THAT— (I) REDUCE IMPORTS OF ENERGY FROM FOREIGN SOURCES; (II) REDUCE ENERGY-RELATED EMISSIONS, INCLUDING GREENHOUSE GASES; (III) IMPROVE THE ENERGY EFFICIENCY OF ALL ECONOMIC SECTORS; (IV) PROVIDE TRANSFORMATIVE SOLUTIONS TO IMPROVE THE MANAGEMENT, CLEAN-UP, AND DISPOSAL OF RADIOACTIVE WASTE AND SPENT NUCLEAR FUEL; AND (V) IMPROVE THE RESILIENCE, RELIABILITY, AND SECURITY OF INFRASTRUCTURE TO PRODUCE, DELIVER, AND STORE ENERGY; AND (B) TO ENSURE THAT THE UNITED STATES MAINTAINS A TECHNOLOGICAL LEAD IN DEVELOPING AND DEPLOYING ADVANCED ENERGY TECHNOLOGIES.” ARPA-E ISSUES THIS FUNDING OPPORTUNITY ANNOUNCEMENT (FOA) UNDER ITS AUTHORIZING STATUTE CODIFIED AT 42 U.S.C. § 16538. THE FOA AND ANY COOPERATIVE AGREEMENTS OR GRANTS MADE UNDER THIS FOA ARE SUBJECT TO 2 C.F.R. PART 200 AS SUPPLEMENTED BY 2 C.F.R. PART 910. ARPA-E FUNDS RESEARCH ON, AND THE DEVELOPMENT OF, TRANSFORMATIVE SCIENCE AND TECHNOLOGY SOLUTIONS TO ADDRESS THE ENERGY AND ENVIRONMENTAL MISSIONS OF THE DEPARTMENT. THE AGENCY FOCUSES ON TECHNOLOGIES THAT CAN BE MEANINGFULLY ADVANCED WITH A MODEST INVESTMENT OVER A DEFINED PERIOD OF TIME IN ORDER TO CATALYZE THE TRANSLATION FROM SCIENTIFIC DISCOVERY TO EARLY-STAGE TECHNOLOGY. FOR THE LATEST NEWS AND INFORMATION ABOUT ARPA-E, ITS PROGRAMS AND THE RESEARCH PROJECTS CURRENTLY SUPPORTED, SEE: HTTP://ARPA-E.ENERGY.GOV/. ARPA-E FUNDS TRANSFORMATIONAL RESEARCH. EXISTING ENERGY TECHNOLOGIES GENERALLY PROGRESS ON ESTABLISHED “LEARNING CURVES” WHERE REFINEMENTS TO A TECHNOLOGY AND THE ECONOMIES OF SCALE THAT ACCRUE AS MANUFACTURING AND DISTRIBUTION DEVELOP DRIVE IMPROVEMENTS TO THE COST/PERFORMANCE METRIC IN A GRADUAL FASHION. THIS CONTINUAL IMPROVEMENT OF A TECHNOLOGY IS IMPORTANT TO ITS INCREASED COMMERCIAL DEPLOYMENT AND IS APPROPRIATELY THE FOCUS OF THE PRIVATE SECTOR OR THE APPLIED TECHNOLOGY OFFICES WITHIN DOE. IN CONTRAST, ARPA-E SUPPORTS TRANSFORMATIVE RESEARCH THAT HAS THE POTENTIAL TO CREATE FUNDAMENTALLY NEW LEARNING CURVES. ARPA-E TECHNOLOGY PROJECTS TYPICALLY START WITH COST/PERFORMANCE ESTIMATES WELL ABOVE THE LEVEL OF AN INCUMBENT TECHNOLOGY. GIVEN THE HIGH RISK INHERENT IN THESE PROJECTS, MANY WILL FAIL TO PROGRESS, BUT SOME MAY SUCCEED IN GENERATING A NEW LEARNING CURVE WITH A PROJECTED COST/PERFORMANCE METRIC THAT IS SIGNIFICANTLY BETTER THAN THAT OF THE INCUMBENT TECHNOLOGY. ARPA-E FUNDS TECHNOLOGY WITH THE POTENTIAL TO BE DISRUPTIVE IN THE MARKETPLACE. THE MERE CREATION OF A NEW LEARNING CURVE DOES NOT ENSURE MARKET PENETRATION. RATHER, THE ULTIMATE VALUE OF A TECHNOLOGY IS DETERMINED BY THE MARKETPLACE, AND IMPACTFUL TECHNOLOGIES ULTIMATELY BECOME DISRUPTIVE – THAT IS, THEY ARE WIDELY ADOPTED AND DISPLACE EXISTING TECHNOLOGIES FROM THE MARKETPLACE OR CREATE ENTIRELY NEW MARKETS. ARPA-E UNDERSTANDS THAT DEFINITIVE PROOF OF MARKET DISRUPTION TAKES TIME, PARTICULARLY FOR ENERGY TECHNOLOGIES. THEREFORE, ARPA-E FUNDS THE DEVELOPMENT OF TECHNOLOGIES THAT, IF TECHNICALLY SUCCESSFUL, HAVE CLEAR DISRUPTIVE POTENTIAL, E.G., BY DEMONSTRATING CAPABILITY FOR MANUFACTURING AT COMPETITIVE COST AND DEPLOYMENT AT SCALE. ARPA-E FUNDS APPLIED RESEARCH AND DEVELOPMENT. THE OFFICE OF MANAGEMENT AND BUDGET DEFINES “APPLIED RESEARCH” AS AN “ORIGINAL INVESTIGATION UNDERTAKEN IN ORDER TO ACQUIRE NEW KNOWLEDGE…DIRECTED PRIMARILY TOWARDS A SPECIFIC PRACTICAL AIM OR OBJECTIVE” AND DEFINES “EXPERIMENTAL DEVELOPMENT” AS “CREATIVE AND SYSTEMATIC WORK, DRAWING ON KNOWLEDGE GAINED FROM RESEARCH AND PRACTICAL EXPERIENCE, WHICH IS DIRECTED AT PRODUCING NEW PRODUCTS OR PROCESSES OR IMPROVING EXISTING PRODUCTS OR PROCESSES.” APPLICANTS INTERESTED IN RECEIVING FINANCIAL ASSISTANCE FOR BASIC RESEARCH (DEFINED BY THE OFFICE OF MANAGEMENT AND BUDGET AS “EXPERIMENTAL OR THEORETICAL WORK UNDERTAKEN PRIMARILY TO ACQUIRE NEW KNOWLEDGE OF THE UNDERLYING FOUNDATIONS OF PHENOMENA AND OBSERVABLE FACTS”) SHOULD CONTACT THE DOE’S OFFICE OF SCIENCE (HTTP://SCIENCE.ENERGY.GOV/). OFFICE OF SCIENCE NATIONAL SCIENTIFIC USER FACILITIES (HTTP://SCIENCE.ENERGY.GOV/USER-FACILITIES/) ARE OPEN TO ALL RESEARCHERS, INCLUDING ARPA-E APPLICANTS AND AWARDEES. THESE FACILITIES PROVIDE ADVANCED TOOLS OF MODERN SCIENCE INCLUDING ACCELERATORS, COLLIDERS, SUPERCOMPUTERS, LIGHT SOURCES AND NEUTRON SOURCES, AS WELL AS FACILITIES FOR STUDYING THE NANOWORLD, THE ENVIRONMENT, AND THE ATMOSPHERE. PROJECTS FOCUSED ON EARLY-STAGE R&D FOR THE IMPROVEMENT OF TECHNOLOGY ALONG DEFINED ROADMAPS MAY BE MORE APPROPRIATE FOR SUPPORT THROUGH THE DOE APPLIED ENERGY OFFICES INCLUDING: THE OFFICE OF ENERGY EFFICIENCY AND RENEWABLE ENERGY (HTTP://WWW.EERE.ENERGY.GOV/), THE OFFICE OF FOSSIL ENERGY AND CARBON MANAGEMENT (HTTPS://WWW.ENERGY.GOV/FECM/OFFICE-FOSSIL-ENERGY-AND-CARBON-MANAGEMENT), THE OFFICE OF NUCLEAR ENERGY (HTTP://WWW.ENERGY.GOV/NE/OFFICE-NUCLEAR-ENERGY), AND THE OFFICE OF ELECTRICITY (HTTPS://WWW.ENERGY.GOV/OE/OFFICE-ELECTRICITY). PROGRAM OVERVIEW THE ROSIE (REVOLUTIONIZING ORE TO STEEL TO IMPACT EMISSIONS) PROGRAM IS A 3-YEAR, $35 MILLION PROGRAM DEVELOPING PATHWAYS TO ZERO EMISSIONS IRONMAKING AND ULTRA-LOW LIFE CYCLE EMISSIONS FOR STEELMAKING. THE PROGRAM SEEKS TO FUND THE DEVELOPMENT AND DEMONSTRATION OF NOVEL TECHNOLOGIES THAT PRODUCE IRON-BASED PRODUCTS FROM IRON-CONTAINING ORES AND ALTERNATIVE FEEDSTOCKS WITHOUT PROCESS EMISSIONS IN THE IRONMAKING STEP. THE PROGRAM’S TECHNOLOGIES WILL DEMONSTRATE A PATH TO COST-COMPETITIVENESS WITH TRADITIONAL INCUMBENT CARBOTHERMIC BLAST FURNACE IRONMAKING. THE TECHNOLOGIES FUNDED THROUGH THIS PROGRAM HAVE TRANSFORMATIVE POTENTIAL, BECAUSE NO TECHNOLOGY ROUTE EXISTS TODAY THAT MEETS BOTH THIS EMISSIONS CONSTRAINT AND THIS COST PARITY GOAL. THE PROGRAM WILL HAVE TWO CATEGORIES. CATEGORY A INCLUDES PROCESSES FROM ORE TO IRONMAKING. CATEGORY B MUST INCLUDE IRONMAKING BUT CAN EXTEND TO DOWNSTREAM STEEL PRODUCTION. TECHNOLOGIES MUST HAVE THE POTENTIAL TO ACHIEVE: • ZERO NON-BIOGENIC GREENHOUSE GAS (GHG) EMISSIONS SPECIFICALLY FROM THE IRONMAKING PROCESS • ULTRA-LOW CRADLE-TO-GATE LIFECYCLE GHG EMISSIONS EMITTED PER TONNE OF IRON OR STEEL PRODUCT (< 0.7 TONNES CO2 EMITTED PER TONNE OF HRC STEEL) • PROCESS AND PRODUCT SCALABILITY OF >15 MILLION TONNES • COST PARITY WITH THE IRON OR STEEL PRODUCT BEING DISPLACED • MATERIALS PROPERTIES CONSISTENT WITH RELEVANT COMMERCIAL PRODUCT BEING DISPLACED • PRODUCED 10 KILOGRAMS (KG) OF PROPOSED PRODUCT BY PROJECT END • A DEMONSTRATED PRODUCTION RATE OF 1 KG/HOUR BY PROJECT END IF SUCCESSFUL, NOVEL IRONMAKING TECHNOLOGIES MEETING THE METRICS SET FORTH BY THE PROGRAM WILL ENABLE A REDUCTION OF U.S. EMISSIONS BY OVER 65 MILLION TONNES (MT) CARBON DIOXIDE EMITTED (CO2E) ANNUALLY (~1% OF U.S. EMISSIONS) AND GLOBAL EMISSIONS BY OVER 2.9 GIGATONNES (GT) ANNUALLY (5.5 % OF GLOBAL EMISSIONS).

ULTRASOUND-GUIDED, ROBOTICALLY STEERABLE GUIDEWIRE FOR ENDOVASCULAR INTERVENTIONS

THIS COOPERATIVE AGREEMENT IS AWARDED TO GEORGIA TECH RESEARCH CORPORATION FOR A PROJECT ENTITLED ''ALKALI HYDROXIDE TRIPLE PHASE FLOW BATTERIES (3PFB)”. THIS AWARD IS BEING MADE IN ACCORDANCE WITH DE-FOA-0003162, PIONEERING RAILROAD, OCEANIC AND PLANE ELECTRIFICATION WITH 1K ENERGY STORAGE SYSTEMS (PROPEL-1K) AND APPLICATION CONTROL NUMBER 3162-1534. THE PROPOSED ALKALI HYDROXIDE TRIPLE PHASE FLOW BATTERY (3PFB) WILL ENABLE REVERSIBLE OPERATION OF ULTRAHIGH ENERGY DENSITY BATTERY CHEMISTRIES (>1,000 WH KG-1 AND WH L-1) VIA AN INNOVATIVE DESIGN INSPIRED BY INTERNAL COMBUSTION ENGINE FUEL INJECTION AND CONVENTIONAL FLOW BATTERIES.

DEVELOPMENT OF NEXT-GENERATION ADVANCED DESIGN METHODS USING VIRTUAL EXPERIMENTATION

UROL:ASC: NEXT-GENERATION BIOLOGICAL SECURITY AND BIO-HACKATHON -BIOTECHNOLOGIES INCLUDE A VARIETY OF TECHNOLOGIES THAT IMPROVE THE QUALITY OF LIFE FOR BILLIONS OF PEOPLE WORLDWIDE. CONTEMPORARY BIOTECHNOLOGIES OFTEN USE LIVING SYSTEMS OR LIVING MATERIALS ? TYPICALLY IN THE FORM OF AN ENGINEERED CELL ? USED TO TREAT OR DIAGNOSE DISEASE, MANUFACTURE BIOFUELS, OR PRODUCE FOODS OR DIETARY SUPPLEMENTS. THESE COULD BE THOUGHT OF AS BIOLOGICAL ASSETS. BIOLOGICAL SECURITY IS A PROCESS THAT IS USED TO PREVENT THE UNWANTED RELEASE OR CAPTURE OF A GIVEN BIOLOGICAL ASSET, ESPECIALLY IF THIS ASSET IS POTENTIALLY PATHOGENIC OR HARMFUL TO THE ENVIRONMENT. CURRENT APPROACHES TO BIOLOGICAL SECURITY RELY PRIMARILY ON RESTRICTING PHYSICAL ACCESS: FOR INSTANCE, THE BIOLOGICAL ASSETS ARE CONFINED IN HIGH BIO-SECURITY LABS. THE CURRENT SOLUTION LACKS ANY MEASURES TO PREVENT THE UNWANTED PROLIFERATION OF THE BIOLOGICAL MATERIAL ONCE THE ASSET HAS BREACHED ITS RESTRICTED ENVIRONMENT. THIS IS THE EQUIVALENT OF PROTECTING YOUR DATA BY HAVING YOUR CELL PHONE UNPROTECTED BY A PASSWORD, BUT STORING IT IN A LOCKED DRAWER. YOUR DATA IS PROTECTED, AS LONG AS THE PHONE REMAINS LOCKED. HOWEVER, ANYBODY GETTING PHYSICAL POSSESSION OF THE PHONE WILL BE ABLE TO USE IT AND ACCESS YOUR DATA. SIMILARLY, WITH THE CURRENT BIOSECURITY APPROACH, ANYBODY CAN USE THE BIOLOGICAL ASSET IF THEY GET ACCESS TO IT. THE OBJECTIVE OF THIS RESEARCH IS TO DEVELOP BIO-SECURITY MEASURES THAT ARE INHERENTLY EMBEDDED IN THE BIOTECHNOLOGY ASSET, MUCH LIKE THE EMBEDDED PASSWORD AUTHENTICATION ON YOUR PHONE. THIS EMBEDDED SECURITY PREVENTS SOMEONE FROM ACCESSING YOUR DATA EVEN IF THEY HAVE PHYSICAL POSSESSION OF THE PHONE. THE SUCCESSFUL COMPLETION OF THIS RESEARCH WILL RESULT IN A PARADIGM SHIFT IN BIOLOGICAL SECURITY AND SECURITY PROTOCOLS. IN ADDITION TO DRAMATICALLY IMPROVING CONTAINMENT AND ASSET PROTECTION, THE RESULTING TECHNOLOGIES WILL INCREASE PUBLIC CONFIDENCE IN THE USE OF ENGINEERED BIOLOGICAL SYSTEMS. THE OBJECTIVE OF THIS RESEARCH IS TO TRANSITION BIOLOGICAL SECURITY FROM AN OPERATIONAL TECHNOLOGY PLATFORM TO A NOVEL BIOLOGICALLY INTRINSIC INFORMATIONAL TECHNOLOGY PLATFORM. TO ACCOMPLISH THIS WILL REQUIRE THE CONVERGENCE OF BIOLOGICAL ENGINEERING INFORMED BY A PRESCRIBED SET OF RULES OF LIFE, CYBERSECURITY PRINCIPLES, AND CHEMICAL ENGINEERING WORKFLOWS. BIOSECURITY PREDICATED ON INTRINSIC INFORMATIONAL TECHNOLOGY WILL ENABLE THE DEVELOPMENT OF SCALABLE ACTIVE PROTECTION MEASURES AND PASSIVE CONTAINMENT STRATEGIES FOR ANY ENGINEERED CHASSIS CELL OR CONSORTIUM OF CHASSIS CELLS. THE USE OF CYBERSECURITY PRINCIPLES WILL ENABLE BIOLOGICAL ENGINEERS AND RELATED STAKEHOLDERS TO DEFINE AND ESTABLISH THE STANDARDS AND PROTOCOLS FOR NEXT-GENERATION BIOSECURITY SYSTEMS, IN ADDITION TO STAGING AND CONDUCTING PENETRATION TESTS FOR THE ITERATIVE IMPROVEMENT OF BIOLOGICAL SECURITY SYSTEMS. THIS PLAN OF ACTION WILL FACILITATE USE-INSPIRED RESEARCH VIA DEPLOYING SYNTHETIC-DECISION MAKING AND SYNTHETIC MEMORY AND COMPLEMENTARY ENGINEERED PARTS TO DESIGN, BUILD, AND TEST ASCENDING ITERATIONS OF BIOSECURITY. ASSESSMENT OF THE IMPACT OF NEXT-GENERATION BIOSECURITY WILL BE ACHIEVED VIA A CONSORTIUM OF CO-PRODUCERS THAT INCLUDE SECURITY SPECIALISTS, POLICY MAKERS, INDUSTRIAL PARTNERS, AND NATIONAL ORGANIZATIONS. IN ADDITION, THIS RESEARCH PROGRAM WILL BE USED TO DEVELOP INNOVATIVE EDUCATION AND TRAINING ACTIVITIES AIMED AT FOSTERING CONVERGENT RESEARCH. THE SOCIETAL IMPACT OF THIS RESEARCH WILL BE MANY-FOLD AND IS AIMED AT REDUCING THE ANXIETY ASSOCIATED WITH THE USE OF ENGINEER BIOLOGICAL SYSTEMS, INCREASED BIOSECURITY MEASURES THAT ARE OF INTEREST TO NATIONAL SECURITY, AND ADDRESSING A GENERAL INTEREST IN IMPROVING CONTAINMENT MEASURES FROM FEDERAL INSTITUTIONS TO IMPROVE BIOSAFETY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

IGERT-CIF21: COMPUTATION-ENABLED DESIGN AND MANUFACTURING OF HIGH PERFORMANCE MATERIALS