Florida State University

NATIONAL HIGH MAGNETIC FIELD LABORATORY RENEWAL 2018-2022

NATIONAL HIGH MAGNETIC FIELD LABORATORY RENEWAL 2013-2017

NATIONAL HIGH MAGNETIC FIELD LABORATORY RENEWAL

NATIONAL HIGH MAGNETIC FIELD LABORATORY RENEWAL 2023-2027 -HIGH MAGNETIC FIELDS ARE A POWERFUL TOOL FOR SCIENTIFIC RESEARCH, AND HAVE WIDE SPREAD TECHNOLOGICAL APPLICATIONS. THE MOST POPULAR APPLICATIONS INCLUDE MAGNETIC RESONANCE IMAGING FOR MEDICAL DIAGNOSIS, HIGH-SPEED MAGNETIC LEVITATION TRAINS, AND POWER GENERATION. SCIENTISTS USE HIGH MAGNETIC FIELDS TO EXPLORE NEW PHYSICAL PHENOMENA, DEVELOP MATERIALS FOR FUTURE GENERATION COMPUTERS, OVERCOME ENERGY CHALLENGES, AND INCREASE OUR UNDERSTANDING OF THE HUMAN BRAIN AND LIFE IN GENERAL. THIS AWARD TO FLORIDA STATE UNIVERSITY SUPPORTS THE OPERATION OF THE NATIONAL HIGH MAGNETIC FIELD LABORATORY (NHMFL) IN 2023-2027. HOME TO MANY WORLD-RECORD MAGNET SYSTEMS, THE NHMFL IS LOCATED AT THREE SITES: FLORIDA STATE UNIVERSITY, THE UNIVERSITY OF FLORIDA AND THE LOS ALAMOS NATIONAL LABORATORY. MORE THAN ONE THOUSAND SIX HUNDRED SCIENTISTS FROM ACADEMIA, GOVERNMENT LABORATORIES, AND INDUSTRY AROUND THE WORLD COME TO THE NHMFL SITES EACH YEAR, AND USE THE POWERFUL MAGNETS AND STATE-OF-THE-ART INSTRUMENTS FOR RESEARCH IN MATERIALS SCIENCE, CONDENSED MATTER PHYSICS, CHEMISTRY, BIOLOGY, AS WELL AS MAGNET TECHNOLOGY. THE RESULTS OF THIS RESEARCH ARE PUBLISHED IN MORE THAN FOUR HUNDRED PAPERS EACH YEAR, AND LEAD TO THE CREATION OF START-UP COMPANIES. THE MAGNET SCIENCE AND TECHNOLOGY DIVISION AND THE ADVANCED SUPERCONDUCTIVITY CENTER AT NHMFL MEET THE LABORATORY?S MISSION TO DEVELOP NEW MATERIALS AND TO BUILD NEW MAGNET SYSTEMS TO ADVANCE THE FRONTIERS OF HIGH MAGNETIC FIELD SCIENCE. THE MISSION OF NHMFL ALSO INCLUDES THE EDUCATION AND TRAINING OF THE NEXT GENERATION OF SCIENTISTS AS WELL AS TO INCREASE THE SCIENTIFIC AWARENESS OF THE BROADER SCIENTIFIC COMMUNITY. A LARGE NUMBER OF SCIENTISTS, INCLUDING 500 UNDERGRADUATE AND GRADUATE STUDENTS, 200 POSTDOCTORAL SCHOLARS, AND 250 EARLY-CAREER SCIENTISTS, USE THE NHMFL AS THEIR TRAINING GROUND. THE NHMFL REACHES TENS OF THOUSANDS OF K-12 STUDENTS, TEACHERS, AND THE PUBLIC THROUGH CLASSROOM LESSONS, SUMMER AND WINTER CAMPS, INTERNSHIPS, TOURS, AND WEB-BASED INTERACTIVE TUTORIALS AND ACTIVITIES. AN OPEN HOUSE EVENT ORGANIZED BY THE SCIENTIFIC AND TECHNICAL STAFF AT THE NHMFL BRINGS MORE THAN 10,000 MEMBERS OF THE GENERAL PUBLIC TO PERFORM HANDS-ON EXPERIMENTS EACH YEAR. THE NHMFL INCLUDES SEVEN USER FACILITIES: STEADY STATE OR DC FIELD, ELECTRON MAGNETIC RESONANCE, NUCLEAR MAGNETIC RESONANCE, AND ION CYCLOTRON RESONANCE AT FLORIDA STATE UNIVERSITY; PULSED FIELD AT LOS ALAMOS NATIONAL LABORATORY; AND HIGH B/T AND ADVANCED MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY AT THE UNIVERSITY OF FLORIDA. USER ACCESS IS PROVIDED THROUGH A COMPETITIVE PROPOSAL REVIEW PROCESS. MAGNETIC FIELDS BOTH PROBE AND MANIPULATE QUANTUM MATERIALS THROUGH COUPLING TO ELECTRON SPINS, ORBITALS, AND CURRENTS, CONTROLLING NUCLEAR SPINS, IMPOSING COMMENSURABILITIES IN ENERGY OR LENGTH SCALES, BREAKING SYMMETRIES AND/OR INDUCING MAGNETIC VORTICES. SCIENTIFIC RESEARCH AT THE NHMFL IS PRIMARILY FOCUSED, BUT NOT LIMITED TO, ON ADVANCING OUR UNDERSTANDING ALONG SEVEN BROAD FRONTIERS: (A) EMERGENT BEHAVIORS THAT RESULTS FROM ELECTRONIC INTERACTIONS IN QUANTUM MATERIALS; (B) THE ROLE OF TOPOLOGY IN GIVING RISE TO NEW PHYSICS IN QUANTUM MATTER; (C) EXPLORING THE NEW PHYSICS REVEALED IN ATOMICALLY-THIN MATERIALS FROM MONOLAYERS TO MULTI-LAYERS TO STRUCTURES WITH MULTI-LAYER STRUCTURES WITH TWISTED INTERLAYER ORIENTATIONS; (D) EXTRACTING ATOMIC-LEVEL DESCRIPTIONS OF COMPLEX ? OFTEN DISORDERED ? MATERIALS, INCLUDING CATALYSTS, GLASSES, AND BATTERIES, USING BOTH NUCLEAR AND ELECTRON MAGNETIC RESONANCE; (E) USING RESONANCE TECHNIQUES ON METABOLITES, BIOMOLECULAR ASSEMBLIES, AND LIVING ORGANISMS TO MEASURE STRUCTURE, DYNAMICS, AND DEVELOPMENT UNDER PHYSIOLOGICAL AND IN VIVO CONDITIONS; (F) USING ION CYCLOTRON RESONANCE TO PROBE CHEMICALLY-COMPLEX ORGANIC MIXTURES AT A MOLECULAR LEVEL, FROM DISSOLVED ORGANIC MATTER TO ANTHROPOGENIC CONTAMINANTS; AND (G) RESEARCHING HIGH-STRENGTH CONDUCTORS AND SUPERCONDUCTORS NECESSARY TO ADVANCE MAGNET TECHNOLOGIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

CARES EMERGENCY RELIEF FUNDING AT FLORIDA STATE UNIVERSITY - INSTITUTION PORTION

CARES EMERGENCY RELIEF FUNDING AT FLORIDA STATE UNIVERSITY

ELECTRIC SHIP RESEARCH AND DEVELOPMENT CONSORTIUM

ADOLESCENT MEDICINE TRIALS NETWORK FOR HIV/AIDS INTERVENTIONS (ATN) SCIENTIFIC LEADERSHIP CENTER - ADOLESCENTS AND YOUNG ADULTS (AYA) UNDER THE AGE OF 25 IN THE UNITED STATES (US) ARE THE LEAST LIKELY OF ALL AGE GROUPS TO: 1) KNOW THEIR HIV STATUS, 2) INITIATE PREP IF HIV-NEGATIVE EVEN WHEN INDICATED, 3) TAKE MEDICATION AS PRESCRIBED, ATTEND MEDICAL APPOINTMENTS, AND BE VIRALLY SUPPRESSED IF LIVING WITH HIV. PERSISTENT RATES OF NEW INFECTIONS AMONG US YOUTH INDICATE THAT EVIDENCE-BASED AND INTEGRATED APPROACHES TO INCREASE THE UPTAKE AND USE OF EFFECTIVE BIOMEDICAL PREVENTION AND TREATMENT PRODUCTS ARE REQUIRED. ADOLESCENCE AND YOUNG ADULTHOOD ARE CHALLENGING DEVELOPMENTAL PERIODS, WITH SIGNIFICANT PHYSICAL, NEUROCOGNITIVE, EMOTIONAL, AND SOCIAL CHANGES. WHILE MULTIPLE VULNERABILITIES AND COMPLEX COMMUNITY FACTORS DRIVE THE HIV EPIDEMIC AMONG YOUTH, THESE DEVELOPMENTAL PERIODS ARE ALSO CHARACTERIZED BY OPPORTUNITIES FOR GROWTH, ACHIEVEMENT, AND RESILIENCE. HIV RESEARCH NETWORKS MUST BE BROAD IN AGENDA, GO BEYOND TRADITIONAL CLINICAL SITES AND INDIVIDUAL LEVEL INTERVENTIONS AND ADDRESS THE MULTI-FACETED, MULTI-LEVEL BARRIERS THAT HAVE THWARTED HIV PREVENTION AND CARE PROGRESS AMONG AYA. THE NEWLY ENVISIONED ADOLESCENT MEDICINE TRIALS NETWORK FOR HIV/AIDS INTERVENTIONS (ATN) IS A MULTI- COMPONENT COLLABORATIVE RESEARCH ENTERPRISE FOCUSED ON THE REDUCTION OF NEW HIV INFECTIONS AMONG AYA IN THE US AS WELL AS IMPROVEMENTS ACROSS THE HIV CONTINUUM OF CARE FOR YOUTH LIVING WITH HIV. SUCH A LARGE-SCALE, COMPLEX CLINICAL RESEARCH PROGRAM DEMANDS HIGH PRODUCTIVITY AND STRONG CONTRIBUTIONS FROM EACH ESSENTIAL COMPONENT. OUR PROPOSED OVERALL NETWORK STRUCTURE IS CONCEPTUALIZED AS A WELL-OILED MACHINE WITH INTERDEPENDENT STRUCTURES WORKING TOGETHER SEAMLESSLY TO ACHIEVE THE MISSION OF THE ATN. THE SCIENTIFIC LEADERSHIP CENTER (SLC) WILL BRING ALL ELEMENTS TOGETHER AND ENSURE THAT THEY FUNCTION COLLABORATIVELY, EFFECTIVELY, AND EFFICIENTLY WITH THE OPERATIONS AND COLLABORATION CENTER (OCC), NIH, AND THE OVERALL NETWORK. THE ATN HAS IDENTIFIED FIVE HIGH PRIORITY RESEARCH AREAS TO ADDRESS THE SUBSTANTIAL AND DISPROPORTIONATE GAPS IN THE HEALTH OUTCOMES OF AYA ACROSS THE HIV PREVENTION AND CARE CONTINUUM. WITH THIS APPLICATION, WE INCLUDE SEVEN HIGHLY INNOVATIVE AND IMPACTFUL CLINICAL TRIALS LED BY TALENTED MULTI-DISCIPLINARY TEAMS, ADDRESSING ALL FIVE PRIORITY RESEARCH AREAS, SPANNING KEY POPULATIONS OF YOUTH, MULTIPLE SOCIOECOLOGICAL SYSTEMS, AND A VARIETY OF REGULATORY PHASES. WE ARE ALSO POISED TO ACCEPT EMERGING RESEARCH OPPORTUNITIES AS THE FIELD OF PREVENTION AND TREATMENT SCIENCE ADVANCES. COMMUNITIES WILL BE SITUATED AT THE CENTER OF THE ATN’S WORK BECAUSE COMMUNITY OWNERSHIP, ENGAGEMENT, AND CONNECTEDNESS ARE CRITICAL FOR SUCCESSFUL RESEARCH IMPLEMENTATION. DRS. HIGHTOW-WEIDMAN AND HOSEK ARE UNIQUELY QUALIFIED AS MPIS TO LEAD THE SLC. BOTH HAVE WORKED IN THE FIELD OF ADOLESCENT HIV PREVENTION AND TREATMENT FOR THE ENTIRETY OF THEIR CAREERS AND HAVE WORKED COLLABORATIVELY WITHIN THE ATN FOR >16 YEARS, GIVING THEM CLEAR INSIGHT ON HOW BEST TO MAKE THIS NEW ITERATION SUCCESSFUL. OUR OVERALL VISION FOR A REDESIGNED AND ROBUST ATN IS ONE THAT NOT ONLY ANTICIPATES AND PLANS FOR ONGOING EVOLUTION IN THE HIV FIELD AND AN EMERGING SCIENTIFIC AGENDA BUT ONE WITH A RENEWED FOCUS ON THE MOST IMPACTFUL SCIENCE AND PRIORITY AREAS.

ESRDC 2016-2021

ELECTRIC SHIP SYSTEMS RESEARCH AND DEVELOPMENT PROGRAM

MILITARY SUICIDE RESEARCH CONSORTIUM

ESRDC: ELECTRIC SHIP RESEARCH AND DEVELOPMENT CONSORTIUM 2021 - 2025

PREDICTING AND PREVENTING THE DEVELOPMENT OF LEARNING D*

SCALE IT UP: EFFECTIVENESS-IMPLEMENTATION RESEARCH TO ENHANCE HIV-RELATED SELF-MANAGEMENT AMONG YOUTH

READING FOR UNDERSTANDING RESEARCH INITIATIVE

MILITARY SUICIDE RESEARCH CONSORTIUM: EXTENSION TO NEW OPPORTUNITIES AND CHALLENGES

MID-SCALE RI-1 (M1:DP): PRELIMINARY & FINAL DESIGN OF THE 40T ALL SUPERCONDUCTING MAGNET

STRENGTHENING TEACHER EDUCATION AND PRACTICE ACTIVITY IN MALAWI (STEP) THE OBJECTIVE OF THE STRENGTHENING TEACHER EDUCATION AND PRACTICE (STEP) ACTIVITY IS TO STRENGTHEN THE HIGHER EDUCATION SYSTEMS TO TRAIN TEACHERS IN EARLY GRADE INSTRUCTION AND PROVIDE PATHWAYS OF CONTINUOUS PROFESSIONAL DEVELOPMENT FOR TEACHERS TO EXCEL IN THEIR DISCIPLINE AND AT THE PRIMARY SCHOOL LEVEL

DESIGN AND FABRICATION OF THE 21 TESLA (T) MAGNET

FOSTERING INSTITUTIONAL RESOURCES FOR SCIENCE TRANSFORMATION: THE FLORIDA-FIRST HEALTH-SCIENCE BRIGADE - PROJECT SUMMARY SEVERAL FACTORS CONTRIBUTE TO FSU’S POTENTIAL TO CREATE CULTURAL TRANSFORMATION THROUGH AN INNOVATIVE APPROACH TO HIRING, SUPPORTING, AND RETAINING URM FACULTY. FIRST, OUR COLLEGE OF MEDICINE WAS FOUNDED IN 2000 TO TRAIN PHYSICIANS TO SERVE RURAL COMMUNITIES THROUGHOUT THE PANHANDLE REGION AND THE STATE OF FLORIDA. GIVEN THE RACIAL AND ETHNIC DIVERSITY OF THESE AREAS, WE HAVE CREATED A RICH COMMUNITY-BASED NETWORK UPON WHICH TO INTEGRATE ACADEMIC HEALTH-SCIENCE EFFORTS ACROSS OUR COLLEGES OF MEDICINE, NURSING, AND ARTS AND SCIENCES. SECOND, IN 2013, THE FLORIDA BOARD OF GOVERNORS DESIGNATED FSU AS ONE OF TWO "PREEMINENT UNIVERSITIES" WHICH TRIGGERED AN INCREASED STATE COMMITMENT OF $75 MILLION FROM 2013 TO 2018. FSU LEADERSHIP INVESTED THESE FUNDS TO ADVANCE HEALTH-SCIENCE RESEARCH, INCLUDING THE CREATION OF THE EQUITY RESEARCH CORNER (A CONSORTIUM OF EIGHT CENTERS AND INSTITUTES) WITH THE MISSION TO ADDRESS EQUITY ISSUES RELATED TO HEALTH, SOCIAL, AND EDUCATIONAL BARRIERS AT THE LEVELS OF INDIVIDUALS, FAMILIES, AND COMMUNITIES . THIRD, FSU HAS CREATED RESOURCES TO SUPPORT FACULTY CONDUCTING CLINICAL TRANSLATIONAL RESEARCH THROUGH OUR NIH-FUNDED CLINICAL TRANSLATIONAL SCIENCE AWARD SUBAWARD. FOURTH, FSU HAS COMMITTED IN ITS STRATEGIC PLAN (GOAL III) TO INSTITUTIONAL CHANGE TO FOSTER DIVERSITY, INCLUSION, AND EQUITY AT ALL LEVELS AND THROUGH THE PRESIDENT’S TASK FORCE OF ANTI-RACISM, EQUITY, AND INCLUSION. WE WILL LEVERAGE THESE RESOURCES TO TEST THE ROBUSTNESS OF THE FLORIDA-FIRST BRIGADE FOR PROMOTING A SELF-REINFORCING COMMUNITY OF SCIENTISTS COMMITTED TO INCLUSIVE EXCELLENCE. IN RESPONSE TO RFA-RM-20-022, WE PROPOSE THREE SPECIFIC AIMS FOR THE OVERALL CORE: AIM 1. ACHIEVE SIGNIFICANT AND SUSTAINABLE CULTURAL CHANGE AT FSU TO ENSURE INCLUSIVE EXCELLENCE AND DIVERSITY AT THE MACRO (INSTITUTIONAL), MESO (HIRING UNIT/CENTER/DEPARTMENT), AND MICRO (FACULTY) LEVELS. AIM 2. RECRUIT, HIRE, AND RETAIN 6 NEW URM FACULTY WITHIN THE CLUSTERS OF CHRONIC DISEASE PREVENTION AND MANAGEMENT OR MENTAL HEALTH TO FORM THE FIRST COHORT AS A REPLICABLE MODEL FOR PROMOTING DIVERSITY, EQUITY, AND INCLUSIVE EXCELLENCE IN HEALTH-SCIENCE RESEARCH AT FSU. AIM 3. DEVELOP AND IMPLEMENT A SYSTEMS-LEVELS APPROACH (MACRO, MESO, MICRO) TO ESTABLISH INDIVIDUAL RESEARCH AND CAREER DEVELOPMENT PLANS AND MENTORSHIP PLANS FOR EACH MEMBER OF THE FIRST COHORT. BY RECALIBRATING THE STANDARD INSTITUTIONAL PRACTICES FOR URM FACULTY RECRUITMENT, DEVELOPMENT, AND RETENTION, THE FLORIDA-FIRST BRIGADE HAS THE POTENTIAL TO PROMOTE DIVERSITY AND INCLUSIVE EXCELLENCE1 FOR THE FIRST COHORT AND SERVE AS AN INNOVATIVE MODEL FOR THE NEXT GENERATION OF FSU HEALTH-SCIENCE FACULTY.

NANOTUBES OPTIMIZED FOR LIGHT WEIGHT EXCEPTIONAL STRENGTH COMPOSITE MATERIALS FOR FCS

TRANSFORMING TEACHER EDUCATION IN ZAMBIA

FLORIDA STATE UNIVERSITY HIGH ENERGY PHYSICS

AUTISM ADAPTIVE COMMUNITY-BASED TREATMENT TO IMPROVE OUTCOMES USING NAVIGATORS (ACTION) NETWORK

MOBILIZING COMMUNITY SYSTEMS TO ENGAGE FAMILIES IN EARLY ASD DETECTION & SERVICES

FOUNDATIONS FOR SUCCESS: DEVELOPING EFFECTIVE MATHEMATICS EDUCATORS THROUGH COGNITIVELY GUIDED INSTRUCTION

THE UNDERLYING SCIENCE OF HIGH CRITICAL CURRENT DENSITY IN ROUND WIRE BI-2212

THE PROPOSED PROJECT IS AN ACADEMIC-INDUSTRY COLLABORATION FOCUSED ON ACHIEVING ZERO GREENHOUSE GAS EMISSIONS FROM COMMERCIAL AVIATION BY 2050. AVOIDANCE OF CO2 AND MINIMIZATION OF NOX EMISSIONS AND CONTRAILS INSPIRES NOVEL HYBRID HYDROGEN-ELECTRIC

SEARCH IN THEORETICAL NUCLEAR AND SUBNUCLEAR PHYSICS

CENTER FOR ACTINIDE SCIENCE AND TECHNOLOGY (CAST)

M TUBERCULOSIS MEMBRANE PROTEIN PHARMACEUTICAL TARGETS

IMR-MIP SERIES CONNECTED HYBRID CONSTRUCTION PHASE

WOU-MMA: STUDIES OF NUCLEAR STRUCTURE AND NUCLEAR ASTROPHYSICS

EXPERIMENTAL HADRONIC NUCLEAR PHYSICS

NATIONAL RESOURCE FOR ADVANCED NMR TECHNOLOGY

SHARE PROGRAM: INNOVATIONS IN TRANSLATIONAL BEHAVIORAL SCIENCE TO IMPROVE SELF-MANAGEMENT OF HIV AND ALCOHOL REACHING EMERGING ADULTS - SHARE P01 ABSTRACT THE PURPOSE OF THE SHARE P01 RESEARCH PROGRAM PROJECT IS TO ADDRESS HIV AND ALCOHOL USE AROUND THREE THEMES; 1) EMERGING ADULTHOOD (AGES 18 -29); 2) SELF-MANAGEMENT OF HIV AND ALCOHOL; AND 3) TRANSLATIONAL BEHAVIORAL SCIENCE. EMERGING ADULTHOOD IS A DEVELOPMENTAL STAGE MARKED BY SIGNIFICANT CHANGE IN SOCIAL ROLES, EXPECTATIONS AS A NEW ADULT, AND INCREASED RESPONSIBILITIES. IT IS ALSO MARKED BY POOR HIV SELF- MANAGEMENT AND INCREASED ALCOHOL USE. EMERGING ADULTS WITH HIV (HEREAFTER CALLED YOUNG PEOPLE LIVING WITH HIV; YPLWH) MAY FACE EVEN MORE CHALLENGES GIVEN INTERSECTIONAL STIGMA. THIS AGE GROUP CONTINUES TO HAVE VERY HIGH RATES OF NEW HIV INFECTIONS. INTERVENTIONS DESIGNED SPECIFICALLY FOR THE UNIQUE DEVELOPMENTAL CHALLENGES OF EMERGING ADULTS ARE NEEDED, YET EMERGING ADULTS ARE OFTEN INCLUDED WITH OLDER ADULTS IN INTERVENTION PROGRAMS. THE CONCEPT OF SELF-MANAGEMENT EMERGED CONCURRENTLY WITHIN BOTH THE SUBSTANCE ABUSE AND CHRONIC ILLNESS LITERATURES, AND FITS WELL WITH THE DEVELOPMENTAL CHALLENGES OF EMERGING ADULTHOOD. SELF-MANAGEMENT, A FRAMEWORK WE HAVE UTILIZED IN OUR WORK WITH YPLWH, REFERS TO THE ABILITY TO MANAGE SYMPTOMS, TREATMENTS, LIFESTYLE CHANGES, AND CONSEQUENCES OF HEALTH CONDITIONS. CURRENT RESEARCH NOW IDENTIFIES INDIVIDUAL-LEVEL SELF-MANAGEMENT SKILLS SUCH AS SELF-CONTROL, DECISION-MAKING, SELF-REINFORCEMENT, AND PROBLEM SOLVING AS THAT PROTECT AGAINST SUBSTANCE USE AND IMPROVE OTHER HEALTH OUTCOMES AND CAN BE EMBEDDED IN THE INFORMATION-MOTIVATION-BEHAVIORAL SKILLS MODEL. ALTHOUGH WE HAVE CONDUCTED MULTIPLE STUDIES WITH YPLWH, ONLY ONE INTERVENTION TO DATE (HEALTHY CHOICES CONDUCTED BY OUR TEAM) IMPROVED BOTH ALCOHOL USE AND VIRAL SUPPRESSION IN YPLWH IN LARGE TRIALS. THE GOAL OF THE SHARE P01 IS TO UTILIZE ADVANCES IN TRANSLATIONAL BEHAVIORAL SCIENCE TO OPTIMIZE BEHAVIORAL INTERVENTIONS AND DEFINE NEW DEVELOPMENTALLY- AND CULTURALLY-APPROPRIATE INTERVENTION TARGETS TO IMPROVE SELF-MANAGEMENT OF ALCOHOL AND HIV IN YPLWH. WE WILL FOCUS OUR EFFORTS IN FLORIDA, A STATE HARDEST HIT BY THE HIV EPIDEMIC BUT WITH A PARTICULARLY STRONG ACADEMIC- COMMUNITY PARTNERSHIP TO SUPPORT TRANSLATION. WE HAVE ASSEMBLED RESEARCH TEAMS TO CONDUCT SELF- MANAGEMENT STUDIES ACROSS THE TRANSLATIONAL SPECTRUM TO ADDRESS SELF-MANAGEMENT AND IMPROVE ALCOHOL USE AND VIRAL SUPPRESSION (AND THEREBY REDUCE TRANSMISSION) IN DIVERSE YPLWH IN FLORIDA. THE P01 WILL CONSIST OF THREE RESEARCH PROJECTS (DEFINE, ENGAGE, AND SUSTAIN), REPRESENTING DIFFERENT STAGES ON THE TRANSLATIONAL SPECTRUM AND TARGETING DIFFERENT CORE COMPETENCIES, SUPPORTED BY TWO CORES (COMMUNITY ENGAGEMENT CORE AND DATA SCIENCE CORE). IF SUCCESSFUL, THE SHARE P01 HAS THE POTENTIAL TO GREATLY ADVANCE PROGRAMS PROMOTING SELF-MANAGEMENT OF HIV AND ALCOHOL USE AMONG A PARTICULARLY VULNERABLE, BUT UNDER-RESEARCHED GROUP, EMERGING ADULTS LIVING WITH HIV. SHARE ALSO HAS A HIGH POTENTIAL FOR SCALE-UP AND IMPLEMENTATION BEYOND FLORIDA AND ACROSS THE UNITED STATES.

ART: INSPIRING THE GENERATION OF NEW IDEAS AND TRANSLATIONAL EXCELLENCE AT FLORIDA STATE UNIVERSITY -THE INSPIRING THE GENERATION OF NEW IDEAS AND TRANSLATIONAL EXCELLENCE AT FLORIDA STATE UNIVERSITY (?IGNITE-FSU?) PROJECT IS A TRANSFORMATIONAL INITIATIVE THAT WILL SERVE AS A CONNECTOR AND CATALYST FOR THE TRANSLATION OF PRODUCTS AND SERVICES OUT OF THE RESEARCH COMMUNITY IN TALLAHASSEE, FL, AND ENSURE MAXIMAL IMPACT ON THE FLORIDA ECONOMY AND BEYOND. IGNITE-FSU WILL BUILD CAPACITY FOR TRANSLATIONAL RESEARCH THROUGH ADDITIONAL STAFF, SUPPORTIVE PROGRAMS, AND MUTUALLY BENEFICIAL PARTNERSHIPS ? ALL GEARED TO IDENTIFY, MATURE, HARVEST, AND TRANSLATE IDEAS INTO IMPACT. THIS WILL PROVIDE THE SPARK NEEDED TO IGNITE A THRIVING INNOVATION ECOSYSTEM THAT BENEFITS THE ENTIRE NORTH FLORIDA REGIONAL ECONOMY BY DEVELOPING AND TRANSLATING TANGIBLE SOLUTIONS TO SOCIETAL CHALLENGES. IGNITE-FSU IS LED BY THE INSTITUTION?S VP FOR RESEARCH, VP FOR FACULTY DEVELOPMENT AND ADVANCEMENT, AND DEAN OF THE GRADUATE SCHOOL, AND INCLUDES THE UNIVERSITY PRESIDENT AS AN ART AMBASSADOR TO DRIVE INSTITUTIONAL CULTURE CHANGE. IGNITE-FSU CONSISTS OF CAPACITY-BUILDING AND TRAINING ACTIVITIES SPECIFICALLY DESIGNED TO ACHIEVE FOUR OVERARCHING OBJECTIVES: (1) ENHANCE FSU?S TRANSLATIONAL RESEARCH INFRASTRUCTURE THROUGH THE ADDITION AND/OR RE-ALIGNMENT OF STAFF, PARTNERSHIPS, AND RESOURCES. (2) FOSTER TRANSLATIONAL AND ENTREPRENEURIAL TALENT BY PROVIDING EDUCATIONAL OPPORTUNITIES FOR FACULTY, STUDENTS (GRADUATE AND UNDERGRADUATE), POSTDOCS, AND ENTREPRENEURS IN THE COMMUNITY. (3) ESTABLISH PATHWAYS TO IMPACT THROUGH IDEA IGNITION AND SEED TRANSLATIONAL RESEARCH PROJECT (?STRP?) PROGRAMS, AND MEANINGFUL INNOVATION ECOSYSTEM PARTNERSHIPS. (4) DEVELOP AN INSTITUTIONAL CULTURE THAT INSPIRES INNOVATION, CELEBRATES INCLUSIVE EXCELLENCE, AND SERVES OUR COMMUNITY AND REGION. THE IGNITE-FSU TEAM WILL BE SUPPORTED BY MENTORSHIP OPPORTUNITIES THROUGH A PARTNERSHIP WITH THE UNIVERSITY OF FLORIDA AND WILL ENSURE THAT THE ENTIRE LOCAL COMMUNITY BENEFITS FROM NSF-FUNDED ACTIVITIES THROUGH PARTNERSHIPS WITH FLORIDA A&M UNIVERSITY, AND A VARIETY OF LOCAL INNOVATION ECOSYSTEM PARTNERS COLLECTIVELY REPRESENTED BY THE ALLIANCE OF ENTREPRENEUR RESOURCE ORGANIZATIONS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

STUDIES OF NUCLEAR STRUCTURE AND NUCLEAR ASTROPHYSICS -THIS AWARD SUPPORTS EXPERIMENTAL NUCLEAR PHYSICS RESEARCH AT FLORIDA STATE UNIVERSITY (FSU). FSU RESEARCHERS PERFORM EXPERIMENTS AT THE ON-CAMPUS JOHN D. FOX SUPERCONDUCTING ACCELERATOR LABORATORY AND AT NATIONAL LABORATORIES IN THE US AND AROUND THE WORLD. THIS RESEARCH PURSUES TWO OVERARCHING GOALS. THE FIRST GOAL IS TO MEASURE NUCLEAR REACTIONS THAT TAKE PLACE IN STELLAR EXPLOSIONS. THESE REACTIONS ARE RESPONSIBLE FOR PRODUCING MOST OF THE NATURALLY OCCURRING ELEMENTS IN THE UNIVERSE. THE SECOND GOAL IS TO MEASURE AND UNDERSTAND THE BEHAVIOR OF EXOTIC NUCLEI ? ISOTOPES THAT HAVE TOO MANY NEUTRONS OR TOO FEW NEUTRONS TO BE STABLE. ALL OF THIS RESEARCH IS PERFORMED IN CLOSE COLLABORATION WITH THEORETICAL PHYSICISTS AT BOTH FSU AND ELSEWHERE. THE FOX LABORATORY?S RESEARCH PROGRAM IS ONE OF THE NATION?S MOST IMPORTANT TRAINING GROUNDS FOR NUCLEAR SCIENTISTS AT BOTH THE PH.D. AND UNDERGRADUATE LEVELS. A COLLABORATION BETWEEN THE FSU LABORATORY AND THE MAYO CLINIC IN JACKSONVILLE IS INVESTIGATING THE PARAMETERS OF CANCER THERAPY IN PREPARATION FOR THE FIRST CARBON ION THERAPY FACILITY IN NORTH AMERICA. THE SCIENTISTS SUPPORTED BY THIS AWARD WILL CONDUCT LABORATORY EXPERIMENTS TO DETERMINE THE RATES AT WHICH REACTIONS OCCUR IN EXPLODING STARS, AND THEREBY UNDERSTAND THE ABUNDANCES OF ELEMENTS IN THE UNIVERSE. THESE EXPERIMENTS WILL ALSO LEAD TO A BETTER INTERPRETATION OF THE ENERGY RELEASE AND NUCLEOSYNTHESIS OUTCOMES BY CALIBRATING THE RELEVANT NUCLEAR REACTIONS. THE EXPERIMENTS WITH EXOTIC NUCLEI WILL PROVIDE RIGOROUS TESTS OF OUR UNDERSTANDING OF THE BEHAVIOR OF ALL NUCLEI. MORE SPECIFICALLY, THESE MEASUREMENTS WILL PROVIDE AN UNDERSTANDING OF SHELL EVOLUTION FROM STABLE TO NEUTRON-RICH NUCLEI. FURTHER, THE DEVELOPMENT OF A TRITON BEAM WILL GIVE THE LAB UNIQUE CAPABILITIES TO STUDY (T,P) REACTIONS SUCH AS 49T(T,P) TO DISTINGUISH BETWEEN THE F5/2 AND F7/2 NEUTRON STATES IN 51TI. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

EARLY HEAD START

CENTRAL VISCEROSENSORY CIRCUITS-STRUCTURE AND FUNCTION

MICROFLUIDIC DEVICES TO DETERMINE ROLES OF ISLET-SECRETED LEPTIN

1/3 EFFECTIVENESS TRIAL OF THE EARLY SOCIAL INTERACTION (ESI) MODEL USING MOBILE TECHNOLOGY FOR TODDLERS WITH AUTISM IDENTIFIED FROM EARLY SCREENING IN PRIMARY CARE - PROJECT ABSTRACT IN RESPONSE TO RFA-MH-18-700, THE GOAL OF THIS COLLABORATIVE R01 IS TO DEMONSTRATE THE THERAPEUTIC VALUE AND COMMUNITY-WIDE IMPLEMENTABILITY OF AN EARLY INTERVENTION (EI) PLATFORM FOR TODDLERS WITH AUTISM SPECTRUM DISORDER (ASD) THAT IS COMPLETELY VIRTUAL, FROM RECRUITMENT THROUGH INTERVENTION. THIS PLATFORM—EARLY SOCIAL INTERACTION MOBILE COACHING (ESI-MC) DEPLOYS INDIVIDUAL TELEHEALTH SESSIONS WITH COACHING AND FEEDBACK TO HELP FAMILIES EMBED INTERVENTION IN EVERYDAY ACTIVITIES. SPECIFICALLY, WE WILL CONDUCT AN EFFECTIVENESS TRIAL OF ESI-MC TO ADDRESS THE IMPORTANT QUESTION OF WHETHER STARTING EVIDENCE-BASED INTERVENTION EARLIER LEADS TO BETTER OUTCOMES THAN STARTING LATER. WE WILL ADDRESS THIS QUESTION BY USING A MODIFIED STEPPED WEDGE DESIGN AND BLENDED IMPLEMENTATION RESEARCH TO ANALYZE DATA OBTAINED WITH ESI-MC START AT 18, 24, OR 30 MONTHS. WE WILL DIAGNOSTICALLY ASCERTAIN 240 CHILDREN FROM A POOL OF 360 18-MONTH-OLDS WITH EARLY SIGNS OF AUTISM, 60 IN EACH OF FOUR US REGIONS (NORTHEAST, SOUTHEAST, MIDWEST, WEST COAST). THEY WILL BE RECRUITED USING A NEW VIRTUAL PLATFORM—MY BABY NAVIGATOR—LINKING A NEW SURVEILLANCE AND SCREENING TOOL, AN APP TO UPLOAD VIDEO-RECORDED HOME OBSERVATIONS AND TELEHEALTH INTERVENTION SESSIONS, AND A PACKAGE OF EDUCATIONAL RESOURCES. THE 240 CHILDREN WILL BE RANDOMLY ASSIGNED TO ONE OF THREE ESI-MC TIMING GROUPS. WE WILL MEASURE CHILD ACTIVE ENGAGEMENT AND SOCIAL COMMUNICATION CHANGE EVERY 6 MONTHS AS THE PRIMARY OUTCOME VARIABLES. OUTCOME MEASURES OF DEVELOPMENTAL LEVEL, AUTISM SYMPTOMS, AND ADAPTIVE BEHAVIOR WILL BE EXAMINED TO MEASURE DIFFERENTIAL TREATMENT EFFECTS. WE WILL ACHIEVE THESE OBJECTIVES THROUGH RESEARCH AIMS: 1. COMPARE THE EFFECTIVENESS OF ESI-MC IMPLEMENTED FOR 6 MONTHS ON PROXIMAL OUTCOME MEASURES OF CHILD ACTIVE ENGAGEMENT, CHILD SOCIAL COMMUNICATION CHANGE, PARENT TRANSACTIONAL SUPPORTS, AND PARENT EVIDENCE-BASED STRATEGY USE (1A) WITH TREATMENT-AS-USUAL (TAU) AT 24 AND 30 MONTHS AND (1B) ACROSS TREATMENT TIMING GROUPS INITIATED AT 18, 24, OR 30 MONTHS. 2. EXAMINE (2A) CHANGE IN PARENT TRANSACTIONAL SUPPORTS AND EVIDENCE-BASED STRATEGY USE AS THE MECHANISM FOR CHANGE AND (2B) INDIVIDUAL CHILD AND FAMILY CHARACTERISTICS THAT MODERATE RESPONSE TO TREATMENT. 3. COMPARE THE EFFECTIVENESS OF INTERVENTION ON SECONDARY OUTCOME MEASURES OF CHILD DEVELOPMENTAL LEVEL, AUTISM SYMPTOMS, AND ADAPTIVE BEHAVIOR (3A) WITH TREATMENT-AS-USUAL (TAU) AT 24 AND 30 MONTHS AND (3B) ACROSS TREATMENT TIMING GROUPS INITIATED AT 18, 24, OR 30 MONTHS. 4. EXPLORE OUTCOMES AT 36 MONTHS, INDIVIDUAL PATTERNS OF CHANGE FROM 18-36 MONTHS, AND PREDICTORS OF CHANGE ACROSS TREATMENT TIMING GROUPS BY ESTIMATING CHILD GROWTH TRAJECTORIES. 5. EXAMINE BARRIERS AND PROMOTIVE FACTORS IMPACTING WIDESPREAD DISSEMINATION, IMPLEMENTATION AND SUSTAINABILITY ACROSS RACIAL, SOCIOECONOMIC AND GEOGRAPHIC LINES. MAXIMIZING THE USE OF MOBILE TECHNOLOGY, ESI-MC OFFERS THE PROSPECT OF A COMMUNITY-VIABLE, SCALABLE AND SUSTAINABLE TREATMENT TO IMPROVE EI SERVICES FOR TODDLERS WITH ASD, PARTICULARLY AMONG MINORITY AND LOW-RESOURCE COMMUNITIES.

THE FLORIDA STATE UNIVERSITY CHILDCARE AND EARLY LEARNING PROGRAM ASSISTANCE TO LOW-INCOME (PELL GRANT) STUDENT PARENTS THROUGH PROVISION OF INFANT, TODDLER, AND PRESCHOOL CHILDCARE SERVICES.

NB3SN SUPERCONDUCTORS FOR THE LHC AND FOR ACCELERATORS BEYOND THE

ESRDC FY14-FY16

EARLY HEAD START

STUDIES OF NUCLEAR REACTIONS AND STRUCTURE

AN APPLIED NOAA RESEARCH CENTER (ARC) AT THE CENTER FOR OCEAN-ATMOSPHERE PREDICTION STUDIES (COAPS)

POST-DOCTORAL RESEARCH FELLOWSHIPS

NATIONAL RESOURCE FOR ADVANCED NMR TECHNOLOGY - NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY IS A UNIQUE SET OF EXPERIMENTAL TOOLS FOR UNDERSTANDING THE INTRICACIES OF BIOLOGY, FROM MACROMOLECULAR COMPLEXES TO COMPLEX MIXTURES, FROM ATOMIC RESOLUTION STRUCTURE TO DYNAMICS ON TIMESCALES OF PICOSECONDS TO SECONDS, FROM CHEMISTRY TO FUNCTIONAL MECHANISMS AND KINETIC PROCESSES. NO OTHER TECHNOLOGY HAS SUCH BREADTH AND POTENTIAL FOR BASIC AND APPLIED RESEARCH AND FOR INTERFACING WITH OTHER TECHNOLOGIES, SUCH AS X-RAY CRYSTALLOGRAPHY, SMALL ANGLE X-RAY SCATTERING, CRYO-EM, MASS SPECTROMETRY, AND MANY OTHER SPECTROSCOPIC AND ANALYTICAL TOOLS. STRUCTURAL CHARACTERIZATION SERVES AS THE FRAMEWORK FOR USING NMR TO UNDERSTAND BIOLOGICAL ACTIVITIES, PROTEIN-PROTEIN AND PROTEIN INTERFACE INTERACTIONS, FUNCTIONAL MECHANISMS, AND KINETIC MODELS. DYNAMICS CAN BE EXCEPTIONALLY WELL CHARACTERIZED BY NMR, WHICH CAN LEAD TO DETAILED UNDERSTANDING ABOUT HOW PROTEINS AND OTHER MACROMOLECULES FUNCTION, HOW COMPLEXES ARE FORMED, AND HOW CERTAIN KINETIC PROCESSES AND RATES ARE ACHIEVED. THE SOLUTION NMR SPECTROSCOPY OF COMPLEX MIXTURES IS PARTICULARLY USEFUL IN COMBINATION WITH MASS SPECTROMETRY FOR METABOLOMICS AND OTHER COMPLEX MIXTURES, WHEREAS SOLID-STATE NMR (SSNMR) IS UNIQUELY CAPABLE OF MEASURING CHEMICAL SHIFT AND QUADRUPOLAR TENSORS TO PROVIDE INSIGHTS INTO CHEMICAL BIOLOGY. HERE, WE FOCUS ON THE FRONTIERS OF NMR TECHNOLOGY MADE POSSIBLE BY RECENT BREAKTHROUGHS IN MATERIALS RESEARCH AND INSTRUMENTATION, AND THEIR IMPLEMENTATION FOR A BROAD USER COMMUNITY PURSUING FUNDAMENTAL QUESTIONS AT ATOMIC RESOLUTION AT THE FOREFRONT OF BIOMEDICAL RESEARCH. THREE TECHNOLOGY DEVELOPMENT PROJECTS (TDP) ADVANCE THE SENSITIVITY OF NMR, EACH FEATURING NOVEL TECHNOLOGIES. TDP1 FEATURES THE USE OF HIGH TEMPERATURE SUPERCONDUCTORS (HTS) FOR RF COILS, LEADING TO HIGH SENSITIVITY FOR SOLUTION NMR SPECTROSCOPY. TDP2 TAKES ADVANTAGE OF OUR 600 MHZ MAS-DNP NMR INSTRUMENT, WHICH WILL PROVIDE ENHANCED SENSITIVITY THROUGH THE TRANSFER OF MAGNETIZATION FROM ELECTRONS TO PROTONS. NEW AND MUCH MORE ROBUST DNP PROBES WITH EXPANDED TEMPERATURE RANGES WILL BE DEVELOPED. TDP3 USES THE 36 T SERIES CONNECTED HYBRID (36T-SCH) AND ALL-HTS 32 T SUPERCONDUCTING (32T-SCM) MAGNETS FOR SSNMR AND SOLUTION NMR SPECTROSCOPY – THE 36T-SCH IS THE HIGHEST-FIELD NMR SPECTROMETER IN THE WORLD, AND THE 32T-SCM WILL BE THE HIGHEST-FIELD SPECTROMETER WITH LOW-TEMPERATURE (4-30 K) CAPABILITIES FOR NMR EXPLORATIONS OF BIOSOLIDS. THESE PLATFORMS WILL LEAD TO DRAMATIC ENHANCEMENTS IN SENSITIVITY AND SPECTACULAR REDUCTIONS IN SIGNAL AVERAGING TIMES. THE SCIENCE WILL BE DRIVEN BY A SELECT TEAM OF TEN SCIENTISTS WITH DRIVING BIOMEDICAL PROJECTS (DBP), AND OVER 30 COLLABORATIVE AND SERVICE PROJECTS (CSP) AND TECHNOLOGY PARTNERSHIP PROJECTS (TPP) THAT SPAN A VERY BROAD RANGE OF BIOMEDICAL AND BIOCHEMICAL RESEARCH AREAS. A MAJOR TEAM EFFORT WILL BE PLACED ON TRAINING A NEW GENERATION OF NMR USERS THROUGH ANNUAL WORKSHOPS, AS WELL AS DISSEMINATION THROUGH PUBLICATIONS AND PRESENTATIONS AT MEETINGS, A WIDE VARIETY OF SCIENTIFIC ORGANIZATIONS, NEWS MEDIA, A DEDICATED WEBSITE FOR THIS RESOURCE, TRAINING AND EDUCATIONAL ACTIVITIES, AND POSTING OF TRAINING LECTURES AND VIDEOS OF DEMONSTRATIONS.

STUDIES OF NUCLEAR REACTIONS AND STUCTURE

THE COST OF GRAIN BOUNDARIES ON THE PERFORMANCE OF SUPERCONDUCTING CAVITIES, MICROSTRUCTURAL, MICROCHEMICAL, AND ELECTROMAGNETIC CHARACTERIZATION

STUDIES OF NUCLEAR REACTIONS AND STRUCTURE

RENEWAL: CYBERCORPS: SCHOLARSHIP FOR SERVICE AT FSU

PREP CHOICE: INCREASING THE USE OF HIV PRE-EXPOSURE PROPHYLAXIS IN AN ERA OF CHOICES

STUDIES OF NUCLEAR REACTIONS AND STRUCTURE

NEW: SISGR - HIGH MAGNETIC FIELDS AS A PROBE TO UNVEIL THE PHYSICAL PROPERTIES OF THE NEWLY DISCOVERED FE OXYPNICTIDE SUPERCONDUCTORS AND RELATED COM

THE SOUTHEASTERN CENTER FOR MICROSCOPY OF MACROMOLECULAR MACHINES (SECM4) - ABSTRACT THE SOUTHEASTERN CENTER FOR MICROSCOPY OF MACROMOLECULAR MACHINES (SECM4), AT FLORIDA STATE UNIVERSITY (FSU) WILL BE A SERVICE CENTER THAT WILL ENABLE SAMPLE PREPARATION AND CRYOGENIC ELECTRON MICROSCOPY (CRYO-EM) IMAGING OF SPECIMENS FOR HIGH-RESOLUTION BIOMOLECULAR STRUCTURE DETERMINATION. THE CENTER WILL BE LED BY DR. SCOTT STAGG AND DR. KENNETH TAYLOR AND WILL FEATURE TWO STAFF MEMBERS WITH COMPLIMENTARY EXPERTISE. THIS WILL BE THE SECOND GENERATION OF THE SECM4. THE FIRST GENERATION PROVIDED HIGH-RESOLUTION CRYO-EM DATA COLLECTION FOR CRYO-EM EXPERTS. IN THE NEW GENERATION OF THE SECM4, WE ARE EXPANDING THE SCOPE OF THE RESOURCE BY OFFSETTING THE COST OF COLLECTING HIGH-RESOLUTION DATA ON THE MICROSCOPE FOR ALL USERS WITH A VERY MODEST USAGE FEE AND ALSO BY OFFERING A LARGE NUMBER OF NEW SERVICES INCLUDING CRYO-EM SPECIMEN OPTIMIZATION, SPECIMEN PREPARATION, SPECIMEN SCREENING, HIGH-RESOLUTION DATA COLLECTION, ROUTINE SINGLE PARTICLE DATA ANALYSIS, AND TRAINING FOR ALL ASPECTS OF CRYO- EM FROM SPECIMEN PREPARATION TO PROCESSING. WE WILL TARGET USERS IN THE GREATER SOUTHEAST TO BE CLIENTS FOR THE CENTER, SPECIFICALLY FOCUSING EXPANDING INTO THE UNDERSERVED IDEA STATES THAT HAVE NOT BENEFITTED FROM THE CURRENT EXPLOSION IN CRYO-EM DUE TO THE EXTRAORDINARY COSTS THAT SERVE AS AN ENTRY BARRIER. OUR APPROACH WILL ENABLE EXCEPTIONAL ECONOMIES OF SCALE BECAUSE WE WILL: 1) ENABLE USERS AT UNIVERSITIES ACROSS THE SOUTHEAST TO GAIN ENTRY THE CRYO-EM FIELD WITHOUT MAKING MULTI-MILLION DOLLAR INVESTMENTS IN INSTRUMENTATION, 2) BY OFFERING SCREENING AND SPECIMEN OPTIMIZATION SERVICES, WE WILL ADDRESS THE BIGGEST BOTTLENECK IN CRYO-EM RIGHT NOW, WHICH IS PREPARATION OF CRYO-EM SAMPLES THAT WILL RECONSTRUCT TO HIGH-RESOLUTION, 3) BY OFFERING IN PERSON TRAINING AND OFFSETTING THE TRAVEL COSTS, WE WILL ENABLE INTERESTED USERS TO GAIN ENTRY INTO THE FIELD OF CRYO-EM WITHOUT HAVING TO SEEK OUT A COLLABORATION WITH AN ALREADY SATURATED CRYO-EM EXPERT.

FLORIDA INTERDISCIPLINARY RESEARCH FELLOWS IN EDUCATION SCIENCES(FIREFLIES)

THE SOUTHEASTERN CONSORTIUM FOR MICROSCOPY OF MACROMOLECULAR MACHINES

AERODYNAMIC/PROPULSION CHARACTERIZATION OF HIGH-SPEED AERODYNAMIC VEHICLES AND MISSILE CONFIGURATION DESIGNS

FSU EARLY HEAD START

INTEGRATION OF NON LINEAR DYNAMIC LOADS INTO THE NEXT GENERATION NAVY SHIPS

PRENATAL AND EARLY LIFE ANTECEDENTS OF PERSONALITY: AN INTERGENERATIONAL LIFESPAN APPROACH

EXPERIENTIAL AND CHILD FACTORS THAT DETERMINE ACQUISITION OF ORTHOGRAPHIC-PHONOLOGICAL REGULARITIES IN A QUASI-REGULAR WRITING SYSTEM: AN INTEGRATED BEHAVIORAL/COMPUTATIONAL/NEUROBIOLOGICAL APPROACH

CONCEPTUAL DESIGN PROPOSAL FOR THE 40 T ALL-SUPERCONDUCTING MAGNET

CHEMOSENSORY TRAINING PROGRAM

SCALING UP IMPLEMENTATION STRATEGIES TO IMPROVE THE DIAGNOSE AND PREVENT PILLARS FOR YOUNG MSM IN FLORIDA - ABSTRACT THIS PROJECT WILL LAUNCH A FLORIDA WIDE EFFORT TO PROMOTE THE DELIVERY OF DEVELOPMENTALLY SENSITIVE, CULTURALLY APPROPRIATE AND EVIDENCE-BASED DIAGNOSE AND PREVENT COUNSELING TESTING AND REFERRAL SERVICES (CTR) FOR YOUNG MEN WHO HAVE SEX WITH MEN (YMSM). THE GOAL IS TO LEVERAGE IMPLEMENTATION SCIENCE STRATEGIES TO IMPROVE THE CAPACITY OF THE HIV HEALTHFORCE TO DELIVER EVIDENCE-BASED PRACTICES (RISK REDUCTION COUNSELING, PREP REFERRAL AND TAILORED MOTIVATIONAL INTERVIEWING) WITHIN CTR SERVICES. OUR RECENT YMSM MYSTERY SHOPPERS STUDIES CONDUCTED AT CTR SITES IN THREE CITIES INDICATED THAT PROVIDERS ARE WOEFULLY UNPREPARED OR DO NOT KNOW HOW TO DELIVER DEVELOPMENTALLY APPROPRIATE, CULTURALLY COMPETENT CTR SERVICES TO YMSM AND MISS OPPORTUNITIES TO DELIVER THESE EVIDENCE-BASED PRACTICES. MYSTERY SHOPPER IS A QUALITY MANAGEMENT STRATEGY TO MONITOR IMPLEMENTATION FIDELITY TO CULTURALLY AND DEVELOPMENTALLY RESPONSIVE EBPS IN CTR SETTINGS. HOWEVER, ASSESSMENT AND FEEDBACK ALONE ARE INSUFFICIENT TO IMPROVE FIDELITY; THE HEALTHFORCE MUST BE PROPERLY TRAINED AND GIVEN TECHNICAL ASSISTANCE. WE PROPOSE INTEGRATING TWO IMPLEMENTATION STRATEGIES: QUALITY MANAGEMENT MYSTERY SHOPPERS AND HEALTHFORCE TRAINING IN TAILORED MOTIVATIONAL INTERVIEWING WITH CENTRALIZED TECHNICAL ASSISTANCE. WE WILL TEST YOUNG ADULT CENTERED HEALTHFORCE TRAINING (YACHT) PACKAGE IN FLORIDA’S SEVEN EHE COUNTIES AMONG THE DEPARTMENT OF HEALTH’S 42 CONTRACTED SITES WHO DELIVERED CTR TO AT LEAST 24 YOUNG MSM IN THE PREVIOUS 12 MONTHS USING A STEPPED WEDGE DESIGN. WE POWER ON BOTH EFFECTIVENESS OUTCOMES (# OF TESTS OF YMSM) AND IMPLEMENTATION OUTCOMES (EBP FIDELITY BASED ON MYSTERY SHOPPER ASSESSMENTS) CONSISTENT WITH A TYPE 2 HYBRID TRIAL.

THE FLORIDA STATE UNIVERSITY-VR CONSORTIUM, IN COLLABORATION WITH THE BUREAU OF JUSTICE ASSISTANCE (BJA), WILL DEVELOP AN IMMERSIVE, SCALABLE VIRTUAL REALITY (VR) PLATFORM FOR POLICE DE-ESCALATION TRAINING. THE PRIMARY OBJECTIVE IS TO ENHANCE AN EXISTING VR TRAINING PLATFORM WITH REALISTIC SCENARIOS THAT INVOLVES INPUT FROM EXPERTS IN VR, LAW ENFORCEMENT TRAINING, AND BEHAVIORAL HEALTH, AND POLICING AND COMMUNITY STAKEHOLDERS. THIS COLLABORATIVE APPROACH WILL ENSURE THE DEVELOPMENT OF A DE-ESCALATION-FOCUSED TRAINING PROGRAM THAT ALIGNS WITH EXISTING TRAINING RESOURCES, EVIDENCE-BASED PRACTICES, AND THE NEEDS OF BOTH LAW ENFORCEMENT AND THE COMMUNITY. KEY PROJECT ACTIVITIES INCLUDE CONDUCTING A NEEDS ASSESSMENT, ENHANCING AN EXISTING VR PLATFORM WITH EMERGING TECHNOLOGY, CREATING MODEL POLICIES AND PROCEDURES FOR VR DE-ESCALATION TRAINING, DEVELOPING TRANSFERABLE AND SCALABLE TRAINING FOR DIVERSE AGENCIES AND SITUATIONS, PILOTING THE TRAINING SESSIONS WITH SELECTED LAW ENFORCEMENT AGENCIES, AND DISSEMINATION OF A VR TRAINING GUIDEBOOK. MILESTONES OF THE PROPOSED PROJECT INCLUDE DEVELOPMENT OF THE VR DE-ESCALATION TRAINING, A PILOT TEST OF THE TRAINING, AND COLLECTION OF INPUT AND PARTICIPATION FROM DIVERSE EXPERTS WITHIN THE FIELD. THE INTENDED BENEFICIARIES OF THIS PROJECT ARE LAW ENFORCEMENT AGENCIES SEEKING TO AUGMENT THEIR EVIDENCE-BASED DE-ESCALATION TRAINING.

GERIATRICS WORKFORCE ENHANCEMENT PROGRAM

EVALUATING THE EFFICACY OF SEQUENCED CENTRAL EXECUTIVE AND BEHAVIORAL PARENT TRAINING FOR CHILDREN WITH ADHD - PROJECT SUMMARY/ABSTRACT THE GOAL OF THE CURRENT PROJECT IS TO COMBINE TWO EVIDENCE-BASED TREATMENTS FOR SCHOOL-AGED CHILDREN WITH ADHD: CENTRAL EXECUTIVE TRAINING (CET) AND BEHAVIORAL PARENT TRAINING (BPT). CET IS A COMPUTERIZED TRAINING INTERVENTION THAT IMPROVES ADHD SYMPTOMS AND ACADEMIC FUNCTIONING BY IMPROVING CHILDREN’S WORKING MEMORY ABILITIES. BPT IS A THERAPEUTIC INTERVENTION THAT IMPROVES FAMILY FUNCTIONING AND CHILD ODD SYMPTOMS BY CHANGING PARENTING BEHAVIORS. THEIR COMBINED USE IS EXPECTED TO PROVIDE COMPLEMENTARY AND ADDITIVE BENEFITS, PARTICULARLY IF CET IS DELIVERED BEFORE BPT.

GENES UNDERLYING REPRODUCTIVE BEHAVIOR AND PHYSIOLOGY

INTEGRATION OF NONLINEAR DYNAMIC LOADS INTO THE NEXT GENERATION NAVY SHIPS PHASE III

DIFFERENTIATING BETWEEN LANTHANIDES AND ACTINIDES

MEMBRANE PROTEIN STRUCTURES AND INTERACTIONS IN THE M. TUBERCULOSIS DIVISOME

VALIDATION OF THE SOCIAL COMMUNICATION CHECKUP AND AUTISM RISK INDICATOR IN THE FIRST YEAR OF LIFE

UNPACKING THE MECHANISMS OF DISPARITIES FOR HIV-RELATED HYPERTENSION IN AFRICAN AMERICAN AND ASIAN PACIFIC AMERICAN MSM

PURPOSE IN LIFE: MECHANISMS TO SUPPORT HEALTHIER COGNITIVE AGING AND REDUCE RISK OF ALZHEIMER'S DISEASE - PROJECT SUMMARY PURPOSE IN LIFE IS THE BELIEF THAT ONE’S LIFE AND ACTIVITIES ARE GOAL-ORIENTED, DIRECTED, AND WORTHWHILE. THIS BELIEF IS ASSOCIATED CONSISTENTLY WITH BETTER OUTCOMES, INCLUDING GREATER ENGAGEMENT IN HEALTH PROMOTING BEHAVIOR (E.G., LESS SMOKING, MORE PHYSICAL ACTIVITY), FEWER CHRONIC DISEASES (E.G., CARDIOVASCULAR DISEASE, DIABETES), AND ULTIMATELY GREATER LONGEVITY. INDEPENDENT OF BEHAVIORAL AND CLINICAL FACTORS, PURPOSE IN LIFE IS ASSOCIATED WITH BETTER COGNITIVE OUTCOMES, INCLUDING LOWER RISK OF ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (ADRD). ADRD REMAINS A SIGNIFICANT CHALLENGE TO PATIENTS, THEIR FAMILIES, AND THE HEALTHCARE SYSTEM, AS IT IS ONE OF THE LEADING CAUSES OF DEATH THAT LACKS DISEASE-MODIFYING TREATMENTS OR CURES. THERE IS A GROWING LITERATURE THAT SHOWS THAT PURPOSE IN LIFE IS PROTECTIVE ACROSS THE ARC OF THE ADRD DISEASE SPECTRUM: IT IS ASSOCIATED WITH BETTER PERFORMANCE ON COGNITIVE TASKS AND LESS COGNITIVE DECLINE PRIOR TO DEMENTIA ONSET, IT IS PROTECTIVE AGAINST COGNITIVE IMPAIRMENTS, BOTH MILD AND SEVERE, AND, EVEN AFTER DIAGNOSIS, IT IS ASSOCIATED WITH FEWER BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA. IN A PARALLEL LITERATURE, THERE IS CONSISTENT EVIDENCE FROM RANDOMIZED CONTROLLED TRIALS THAT PURPOSE IN LIFE IS MALLEABLE AND CAN BE INCREASED THROUGH INTERVENTION. PURPOSE IN LIFE IS THUS POISED TO BE A POWERFUL TARGET OF INTERVENTION TO IMPROVE COGNITIVE OUTCOMES, FROM MAINTAINING COGNITIVE FUNCTION IN MIDDLE ADULTHOOD TO IMPROVING OUTCOMES IN DEMENTIA CARE. THE NEXT STEP IN INTERVENTION DEVELOPMENT IS TO IDENTIFY THE PUTATIVE MECHANISMS OF ACTION HYPOTHESIZED TO CHANGE IN RESPONSE TO THE INTERVENTION AND EXPLAIN THE RELATION BETWEEN PURPOSE AND BETTER COGNITIVE OUTCOMES. ONCE THESE MECHANISMS ARE IDENTIFIED, INTERVENTIONS THAT INCREASE PURPOSE TO IMPROVE COGNITIVE OUTCOMES CAN BE DEVELOPED AND TESTED. AS A STEP TOWARD THIS LONG-TERM GOAL, THE PRESENT STUDY WILL USE ECOLOGICAL MOMENTARY ASSESSMENTS (EMA) TO IDENTIFY THE DAILY MECHANISMS RESPONSIBLE FOR THE ASSOCIATION BETWEEN PURPOSE IN LIFE AND HEALTHIER COGNITIVE OUTCOMES. IN PARTICULAR, WE WILL TEST THE HYPOTHESIS THAT PURPOSE IN LIFE IS ASSOCIATED WITH GREATER MOMENTARY ENGAGEMENT AND BETTER MOMENTARY COGNITION, WHICH WILL SUPPORT HEALTHIER COGNITIVE FUNCTION OVER TIME. WE WILL ADDRESS THESE ASSOCIATIONS IN THREE GROUPS CONSIDERED CRITICAL POPULATIONS FOR INTERVENTION: OLDER ADULTS WITH SUBJECTIVE COGNITIVE IMPAIRMENT, OLDER ADULTS WITH HEALTHY COGNITION, AND MIDDLE-AGED ADULTS. THIS RESEARCH WILL PROVIDE MUCH NEEDED INFORMATION ON PUTATIVE MECHANISMS OF ACTION THAT EXPLAIN HOW PURPOSE PROTECTS COGNITION. SUCH INFORMATION IS CRITICAL TO DEVELOP PURPOSE INTERVENTIONS THAT PROMOTE HEALTHIER COGNITIVE AGING.

SPECIAL EDUCATION RESEARCH PROGRAM

EDUCATION RESEARCH PROGRAM

NATIONAL CENTER FOR EDUCATION RESEARCH

INFRARED OPTICAL STUDY OF GRAPHENE IN HIGH MAGNETIC FIELDS

SOURCES AND FUNCTIONAL CONSEQUENCES OF INDIVIDUAL DIFFERENCES IN HUMAN FUNCTIONAL BRAIN NETWORKS RELATED TO CONTROLLED BEHAVIOR

COMPARING THE EFFECTIVENESS OF TWO ALCOHOL+ADHERENCE INTERVENTIONS FOR HIV+ YOUTH

TRANSFORMING HEALTH EQUITY RESEARCH IN INTEGRATED PRIMARY CARE: ANTIRACISM AS A DISRUPTIVE INNOVATION - INCREASED MEDIA ATTENTION REGARDING COVID-RELATED HEALTH DISPARITIES COMBINED WITH HORRIFIC INSTITUTIONALIZED VIOLENCE AGAINST BLACK AMERICANS HAVE REVITALIZED THE CALL TO ACTION TO ADDRESS SYSTEMIC RACISM IN HEALTH CARE. AMONG THE CONSEQUENCES OF SYSTEMIC RACISM IN HEALTH CARE ARE SIGNIFICANT HEALTH DISPARITIES IN PREVALENCE, DIAGNOSIS, AND TREATMENT OF COMORBID PHYSICAL AND MENTAL HEALTH CONDITIONS. DESPITE DECADES OF STUDIES ACKNOWLEDGING HEALTH DISPARITIES BASED ON RACE AND AN INCREASED AWARENESS OF THE SOCIAL DETERMINANTS OF HEALTH, WE SEEM TO BE LIGHTYEARS AWAY FROM SIGNIFICANT CHANGE. THERE ARE SHOCKINGLY FEW EVIDENCE-BASED INTERVENTIONS TO CHANGE RACISM ATTITUDES, BEHAVIORS, AND PRACTICES AT THE PROVIDER AND ORGANIZATIONAL-SYSTEMS LEVEL. NEW PARADIGMS ARE NEEDED TO INTERVENE ON, AND NOT JUST DOCUMENT, RACISM IN HEALTH CARE SYSTEMS. WE PROPOSE TO DEVELOP AND TEST A TRANSFORMATIVE PARADIGM FOR TRANSLATING BASIC BEHAVIORAL AND SOCIAL SCIENCE INTO NEW ANTI-RACISM INTERVENTIONS FOR PRIMARY CARE SETTINGS. THE PARADIGM IS THE FIRST OF ITS KIND TO INTEGRATE COMMUNITY-BASED PARTICIPATORY RESEARCH, SYSTEMS SCIENCE, DIFFUSION OF INNOVATION THEORY, AND ITEM RESPONSE THEORY, LEVERAGING AN ESTABLISHED FRAMEWORK OF EARLY PHASE TRANSLATIONAL BEHAVIORAL AND SOCIAL SCIENCE TO RIGOROUSLY DEFINE NEW ANTI-RACISM INTERVENTIONS WITHIN COMPLEX HEALTH SYSTEMS AND RIGOROUSLY DEVELOP MEASURES TO ASSESS IMPACT. ANTI-RACISM IS A DISRUPTIVE INNOVATION IN INTEGRATED PRIMARY CARE SYSTEMS IN THE UNITED STATES, ONE THAT CAN BE RIGOROUSLY MAPPED USING COMMUNITY-ENGAGED SYSTEMS SCIENCE METHODS. THIS MAP IDENTIFIES “INFLECTION POINTS” LIKELY TO RESULT IN THE MOST IMPACTFUL INTERVENTION TARGETS, AND THEN ESTABLISHED PATHWAYS CAN BE USED TO TRANSLATE FUNDAMENTAL BEHAVIORAL AND SOCIAL SCIENCE DISCOVERIES INTO NEW INTERVENTIONS AT THESE POINTS. SYSTEMS SCIENCE MODELING CAN THEN SIMULATE POTENTIAL INTERVENTIONS AND PRODUCE MATHEMATICAL STANDARDS FOR INTERVENTION EFFICACY IN FUTURE TRIALS. THIS TRANSFORMATIVE PARADIGM WILL ALSO DETAIL INNOVATIVE METHODS TO DEVELOP EFFICIENT AND EFFECTIVE MEASUREMENT TOOLS TO RIGOROUSLY MONITOR OUTCOMES. THIS TRANSFORMATIVE PARADIGM OF ANTIRACISM AS A DISRUPTIVE INNOVATION WILL NOT ONLY REVOLUTIONIZE HEALTH EQUITY INTERVENTIONS IN INTEGRATED PRIMARY CARE SYSTEMS BUT WILL PROVIDE A FOUNDATION FOR IMPROVING HEALTH CARE RACISM IN OTHER SYSTEMS.

EFFICACY OF THE EARLY SOCIAL INTERACTION (ESI) MODEL FOR TODDLERS WITH EARLY SIGNS OF AUTISM SPECTRUM DISORDER IN COMMUNITY EARLY INTERVENTION PROGRAMS

STRUCTURES OF RNA PROCESSING AND SILENCING ENZYMES IN PROKARYOTES

MRI: DEVELOPMENT OF A NEXT GENERATION POLYSONIC WIND TUNNEL FOR TRANSFORMATIVE ACTIVE CONTROL TECHNOLOGIES AND NON-INTRUSIVE FLOW DIAGNOSTICS

HIGH FIELD SUPERCONDUCTOR DEVELOPMENT AND UNDERSTANDING

NEUROENDOCRINE INTEGRATION OF SATIETY AND FOOD REWARD

EDUCATION RESEARCH PROGRAM

HIGH FIELD SUPERCONDUCTOR DEVELOPMENT AND UNDERSTANDING

ATTENTION TRAINING TO MODIFY ERN AND RISK FOR ANXIETY IN ADOLESCENCE

EM STUDIES ON MUSCLE

REDUCING CARDIOVASCULAR DISEASE RISK IN MID-LIFE AND OLDER AFRICAN AMERICANS

THE ADHERENCE PROMOTION WITH PERSON-CENTERED TECHNOLOGY (APPT) PROJECT: PROMOTING ADHERENCE TO ENHANCE THE EARLY DETECTION AND TREATMENT OF COGNITIVE DECLINE

CYBERCORPS SCHOLARSHIP FOR SERVICE (RENEWAL): DEFENDING THE NATIONAL CYBER INFRASTRUCTURE -THIS PROJECT SUPPORTS THE CONTINUATION OF THE CYBERCORPS? SCHOLARSHIP FOR SERVICE (SFS) PROGRAM AT FLORIDA STATE UNIVERSITY (FSU). RENEWAL FUNDING WILL SUPPORT 32 SCHOLARSHIPS TO UNDERGRADUATE AND GRADUATE SFS SCHOLARS SEEKING COMBINED BACHELOR OF SCIENCE/MASTER OF SCIENCE OR MASTER OF SCIENCE DEGREES IN CYBERSECURITY. THE PROJECT'S COMPONENTS ARE DESIGNED TO PROVIDE GRADUATES WITH GENERAL COMPUTING AND SECURITY SKILLS THAT WILL DIRECTLY IMPACT THE FEDERAL WORKFORCE'S INFORMATION ASSURANCE AND FORENSICS CAPABILITIES. SFS SCHOLARS WILL HAVE THE OPPORTUNITY TO COLLABORATE ON REAL-WORLD PROJECTS TO GAIN PRACTICAL EXPERIENCE AND ENHANCE INTERNSHIP AND JOB PLACEMENT PROSPECTS. IN ADDITION, THE RENEWAL PROJECT AIMS TO STRENGTHEN EFFORTS TO ENGAGE MEMBERS OF GROUPS THAT ARE UNDERREPRESENTED IN THEIR PARTICIPATION IN THE CYBERSECURITY FIELD, AS WELL AS OTHER NON-TRADITIONAL STUDENTS. THE PROPOSED PROJECT WILL ADDRESS THE CURRENT CYBERSECURITY PERSONNEL GAP THROUGH THE FOLLOWING SEVEN OBJECTIVES. FIRST IS TO IDENTIFY AND RECRUIT SFS SCHOLARS WITH AN EMPHASIS ON RECRUITING STUDENTS WHO ARE WOMEN OR MEMBERS OF MINORITY GROUPS THAT HAVE NOT HAD A HISTORY OF ENGAGEMENT WITH THE FIELD OF CYBERSECURITY. SECOND IS TO IMPROVE RETENTION THROUGH COHORT CLASS ENROLLMENTS, DEDICATED TEACHING ASSISTANTS, HANDS-ON CURRICULA, AND INTERACTIONS BETWEEN THE SFS SCHOLARS AND EXISTING ACADEMIC SUPPORT UNITS. THIRD IS TO IDENTIFY INTERNSHIP, CUTTING-EDGE RESEARCH (AT THE INTERSECTIONS OF CYBERSECURITY, ARTIFICIAL INTELLIGENCE, AND MACHINE LEARNING), LEADERSHIP, AND OUTREACH OPPORTUNITIES FOR THESE SFS SCHOLARS. FOURTH IS TO GATHER FEEDBACK FROM CURRENT SFS SCHOLARS TO REFINE THE SCHOLARSHIP PROJECT'S OFFERINGS AND CURRICULA. FIFTH IS TO USE A SYSTEM TO ENDORSE AND PLACE AT LEAST 70% OF FSU SFS GRADUATES IN FEDERAL EXECUTIVE AGENCIES, UP TO 20% OF GRADUATES IN OTHER AGENCIES, AND UP TO 10% OF GRADUATES IN INSTITUTIONS THAT OFFER SFS SCHOLARSHIPS. SIXTH IS TO IDENTIFY FACTORS THAT INFLUENCE STUDENTS TO OBTAIN AN SFS SCHOLARSHIP AND INCREASE THE PARTICIPATION OF WOMEN AND MINORITIES IN THE SFS PROGRAM. FINALLY, THE SEVENTH OBJECTIVE IS TO DISSEMINATE EDUCATIONAL FINDINGS AND CYBERSECURITY RESEARCH THROUGH PUBLICATIONS. THIS PROJECT IS SUPPORTED BY THE CYBERCORPS? SCHOLARSHIP FOR SERVICE (SFS) PROGRAM, WHICH FUNDS PROPOSALS ESTABLISHING OR CONTINUING SCHOLARSHIP PROGRAMS IN CYBERSECURITY AND ALIGNS WITH THE U.S. NATIONAL CYBER STRATEGY TO DEVELOP A SUPERIOR CYBERSECURITY WORKFORCE. FOLLOWING GRADUATION, SCHOLARSHIP RECIPIENTS ARE REQUIRED TO WORK IN CYBERSECURITY FOR A FEDERAL, STATE, LOCAL, OR TRIBAL GOVERNMENT ORGANIZATION FOR THE SAME DURATION AS THEIR SCHOLARSHIP SUPPORT. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

FABRICATING AND TESTING OF A 30 METER LONG COAXIAL SUPERCONDUCTING DIPOLE POWER CABLE

STRUCTURAL AND MECHANISTIC INSIGHTS INTO ANTIBODY NEUTRALIZATION OF HUMAN METAPNEUMOVIRUS

BREAKING BONDS IN PRAIRIE VOLES - IN HUMANS, SOCIAL ATTACHMENT WITH PARTNERS, RELATIVES, OR FRIENDS ACT AS A PROTECTIVE BUFFER AGAINST MANY NEGATIVE CONSEQUENCES OF LIFE STRESS, WHEREAS LACK OF SOCIAL ATTACHMENTS CAN LEAD TO SERIOUS PATHOLOGIES INCLUDING DYSPHORIA, ANXIETY, DEPRESSION, SLEEP DISTURBANCE, CARDIOVASCULAR PROBLEMS, AND IMMUNE SYSTEM DEFICITS. IN THE SOCIAL PRAIRIE VOLES, ACUTE AND CHRONIC SOCIAL ISOLATION AS WELL AS PARTNER SEPARATION INDUCE ANXIETY AND DEPRESSION-LIKE BEHAVIORS, ENHANCE STRESS RESPONSE, AND ALTER ACTIVITIES OF SEVERAL NEUROCHEMICAL SYSTEMS, INCLUDING THE OXYTOCINERGIC SYSTEM. DATA FROM OUR GROUP AND OTHERS HAVE SHOWN THAT OXYTOCIN (OT) IS INVOLVED NOT ONLY IN THE FORMATION OF PAIR BONDS IN THIS SPECIE, BUT ALSO IN THE RESPONSE TO SOCIAL ISOLATION/ PARTNER SEPARATION AS WELL AS SOCIAL BUFFERING OF STRESS RESPONSES. IN THIS PROPOSAL, WE WILL VERIFY THE OVERALL HYPOTHESIS THAT BREAKING BONDS IN VOLES ALTER THE OT CIRCUITRY PROJECTING FROM THE HYPOTHALAMIC PVN TO THE NUCLEUS ACCUMBENS (WHICH REPRESENTS 90% OF OT PROJECTIONS TO NUCLEUS ACCUMBENS) AND LEADS TO NEGATIVE CONSEQUENCES ON SOCIAL BEHAVIORS IN MALE AND FEMALE PRAIRIE VOLES.

PERSONALITY AND DEMENTIA: MECHANISMS AND TRAJECTORIES

RELATIVISTIC QUANTUM DYNAMICS IN THE NON-EQUILIBRIUM REGIME

RAPID TREATMENT OF PTSD WITH ACCELERATED NONINVASIVE BRAIN STIMULATION

FOSTERING INDEPENDENCE, REFLECTION, AND ENGAGEMENT THROUGH WIDE-REACHING OUTREACH, REVOLUTIONARY KNOWLEDGE, AND STUDENT-LED SCHOLARSHIP FOR AMERICA’S 250TH ANNIVERSARY (FIREWORKS250)

RANDOMIZED CLINICAL TRIAL OF A BRIEF, ANXIETY INTERVENTION FOR MILD COGNITIVE IMPAIRMENT/MILD ALZHEIMER?S DISEASE AND THEIR CARE PROVIDERS - ANXIETY PSYCHOPATHOLOGY IS HIGHLY PREVALENT IN PEOPLE LIVING WITH MILD COGNITIVE IMPAIRMENT (MCI), ALZHEIMER'S DISEASE AND RELATED DEMENTIAS (ADRD) AND THEIR CARE PARTNERS. RECENT META- ANALYSES SUGGEST CLINICALLY SIGNIFICANT ANXIETY SYMPTOMS IN APPROXIMATELY 40% OF THOSE WITH ADRD AND APPROXIMATELY 25% IN THEIR CARE PARTNERS, AS WELL AS INCREASED RATES OF ANXIETY IN CLINICAL SAMPLES OF PATIENTS WITH MCI. MOREOVER, A RECENT REVIEW SUGGESTS THAT ELEVATED ANXIETY IS A MARKER FOR AND POTENTIALLY CONTRIBUTES TO EARLIER ONSET OF ADRD SYMPTOMS AMONG THOSE WITH MCI. DESPITE THIS, THERE ARE NO WELL-ESTABLISHED INTERVENTIONS FOR ANXIETY IN MCI/ADRD OR THEIR CARE PARTNERS. MOREOVER, PRIOR TREATMENT PROTOCOLS FOR ANXIETY ARE LENGTHY, EXCESSIVELY RELY ON INTACT MEMORY AND COGNITIVE ABILITIES, AND RESULT IN HIGH DROPOUT RATES. BRIEF, MECHANISM FOCUSED INTERVENTIONS OFFER AN EFFICIENT, ALTERNATIVE APPROACH TO DEALING WITH ANXIETY IN PEOPLE WITH MCI/ADRD AND THEIR CARE PARTNERS. ANXIETY SENSITIVITY (AS) IS AN EXTREMELY WELL-RESEARCHED RISK MECHANISM RELEVANT TO THE GENESIS AND MAINTENANCE OF ANXIETY AND OTHER FORMS OF PSYCHOPATHOLOGY. AS ACTS AS A BROAD STRESS AMPLIFICATION FACTOR AS IT EXACERBATES THE EXPERIENCE OF SOMATIC AND EMOTIONAL SENSATIONS, LEADING TO INCREASED DISTRESS. AS SUCH, INDIVIDUALS WITH ELEVATED AS ARE MORE LIKELY TO EXPERIENCE EXAGGERATED RESPONSES TO A WIDE ARRAY OF STRESSORS INCLUDING COGNITIVE SYMPTOMS (E.G., CONCENTRATION AND MEMORY PROBLEMS). FORTUNATELY, FOCUSED INTERVENTIONS HAVE BEEN DEVELOPED SHOWING THAT AS CAN BE QUICKLY AND EFFECTIVELY REDUCED. THESE INTERVENTIONS INCLUDE PSYCHOEDUCATION BUT FOCUS HEAVILY ON INTEROCEPTIVE EXPOSURE (IE) EXERCISES DESIGNED TO REDUCE CONDITIONED FEAR TO ANXIETY-PROVOKING INTERNAL STIMULI. ACROSS CLINICAL TRIALS, EVIDENCE SHOWS SUCH INTERVENTIONS CAN MARKEDLY REDUCE AS AND THAT THESE REDUCTIONS MEDIATE REDUCTIONS IN ANXIETY SYMPTOMS. WHILE AS INTERVENTIONS HAVE BEEN SUCCESSFULLY USED IN A VARIETY OF SAMPLES, THEY HAVE NOT BEEN TESTED FOR PEOPLE WITH MCI/ADRD. WE PROPOSE TO CONDUCT A FULLY POWERED RANDOMIZED CLINICAL TRIAL (RCT) TO TEST A BRIEF, CBT-BASED INTERVENTION, CALLED COGNITIVE ANXIETY SENSITIVITY TREATMENT (CAST) FOR PEOPLE WITH MCI/MILD AD. WE BELIEVE THE IE COMPONENT OF CAST WILL BE PARTICULARLY RELEVANT TO MCI/MILD ADRD WHERE LEARNING MAY BE COMPROMISED DUE TO COGNITIVE DECLINE. MOREOVER, OUR PRELIMINARY DATA SUGGEST THAT CAST YIELDS MEDIUM TO HIGH EFFECT SIZE REDUCTIONS IN AS AND ANXIETY IN OLDER ADULTS WITH MCI. DYADS CONSISTING OF MCI/MILD AD AND THEIR CARE PARTNERS WILL BE RANDOMIZED TO CAST TO A HEALTH EDUCATION CONTROL (HEC) CONDITION (N = 197) AND FOLLOWED FOR SIX MONTHS TO EVALUATE CHANGE IN ANXIETY AND DISTRESS, COGNITIVE FUNCTIONING AND QUALITY OF LIFE.

PSYCHOPHYSICAL EVALUATION OF TASTE FUNCTION

GERIATRICS WORKFORCE ENHANCEMENT PROGRAM

RESISTANCE TRAINING MODULATION OF FAT METABOLISM IN OBESE POSTMENOPAUSAL WOMEN - PROJECT SUMMARY PREDIABETES, A COMORBIDITY OF OBESITY AND A PRECURSOR OF TYPE 2 DIABETES, AFFECTS MORE THAN ONE-HALF OF WOMEN OVER 60 YEARS OF AGE. OBESITY HAS MULTIPLE CAUSES; HOWEVER, IT IS KNOWN THAT OBESE INSULIN RESISTANT INDIVIDUALS HAVE A REDUCED ABILITY TO ALTER RESTING AND STIMULATED LIPOLYSIS (FAT BREAKDOWN). THIS LACK OF FLEXIBILITY TO RESPOND TO STIMULI THAT REGULATE LIPOLYSIS HAS BEEN ATTRIBUTED, ALMOST ENTIRELY THROUGH STUDIES IN MALES, TO CHANGES IN THE PREDOMINANT (CATECHOLAMINE-MEDIATED) LIPOLYTIC PATHWAY. OUR PUBLISHED PRELIMINARY DATA DEMONSTRATE THAT ACUTE RESISTANCE EXERCISE INCREASES LIPOLYSIS IN NON-OBESE WOMEN. PUBLISHED DATA ALSO INDICATE THAT RESISTANCE EXERCISE, LIKE ENDURANCE EXERCISE, INCREASES LIPOLYTIC SENSITIVITY IN MEN. HOWEVER, THE ALTERATIONS IN LIPOLYTIC RESPONSE DUE TO RESISTANCE, AS COMPARED TO ENDURANCE, TRAINING MATCHED FOR ENERGY EXPENDITURE HAVE NOT BEEN INVESTIGATED. IT IS ALSO UNKNOWN HOW TRAINING ALTERS LIPOLYSIS DURING GENERAL PHYSICAL ACTIVITY (WALKING), WHICH ACCOUNTS FOR THE MAJORITY OF ACTIVITY PEOPLE ENGAGE IN DURING A TYPICAL DAY OUTSIDE OF PLANNED EXERCISE. FURTHERMORE, THE LACK OF PRIOR INVESTIGATIONS IN THIS AREA IN WOMEN POINTS TO THE NEED FOR RESISTANCE TRAINING STUDIES OF FAT METABOLISM IN WOMEN TO DETERMINE IF RESISTANCE TRAINING IS AS EFFECTIVE AS ENDURANCE TRAINING. THEREFORE, THE OVERALL OBJECTIVE OF THIS STUDY IS TO COMPARE THE EFFECTS OF 12 WEEKS OF RESISTANCE TRAINING TO ENDURANCE TRAINING WITH RESPECT TO FAT METABOLISM, WITH A FOCUS ON LIPOLYSIS IN POSTMENOPAUSAL WOMEN WITH OBESITY AND PREDIABETES. OUR CENTRAL HYPOTHESIS IS THAT BOTH 12 WEEKS OF RESISTANCE TRAINING AND 12 WEEKS OF ENDURANCE TRAINING WILL INCREASE LIPOLYTIC FLEXIBILITY. WE WILL COMPARE THE EFFECTS OF ENDURANCE TRAINING TO THE EFFECTS IMPARTED BY CALORIE-MATCHED ENDURANCE EXERCISE TRAINING. WE WILL DETERMINE WITH POWERFUL IN-VIVO MICRODIALYSIS AND STABLE ISOTOPE METHODOLOGIES THE EXTENT TO WHICH 12 WEEKS OF RESISTANCE TRAINING, AS COMPARED TO CALORIE-MATCHED ENDURANCE TRAINING: A) INCREASES PHYSICAL ACTIVITY (WALKING)-STIMULATED WHOLE-BODY AND REGIONAL LIPOLYSIS (AIM 1); B) INCREASES LOCAL ADRENERGIC REGULATION OF LIPOLYSIS IN SUBCUTANEOUS ABDOMINAL AND GLUTEAL ADIPOSE TISSUE (AIM 2); AND C) INCREASES INSULIN-MEDIATED SUPPRESSION OF WHOLE-BODY AND REGIONAL LIPOLYSIS (AIM 3) IN POSTMENOPAUSAL WOMEN WITH OBESITY AND PREDIABETES. SECONDARILY, FAT OXIDATION, LIPOGENESIS AND ADIPOGENESIS IN ADIPOSE TISSUE, AS WELL AS LIPOLYTIC ACTIVITY IN SKELETAL MUSCLE, WILL ALSO BE STUDIED TO DEVELOP A GLOBAL UNDERSTANDING OF FAT METABOLISM RESPONSE TO RESISTANCE EXERCISE TRAINING. IN ADDITION, WE WILL INVESTIGATE THE INFLUENCE OF RESISTANCE AND ENDURANCE TRAINING ON GLUCOSE PROFILE UNDER LABORATORY AS WELL AS FREE-LIVING CONDITIONS, AS POOR GLUCOSE CONTROL IS LINKED TO THE ABERRANT LIPID METABOLISM COMMONLY ASSOCIATED WITH OBESITY. THESE STUDIES WILL PROVIDE A GREATER UNDERSTANDING OF HOW THESE EXERCISE MODALITIES AFFECT METABOLISM IN WOMEN WITH OBESITY AND PREDIABETES, ALLOWING PRACTITIONERS TO MAKE MORE EVIDENCE- BASED EXERCISE PRESCRIPTIONS INTENDED TO IMPROVE BODY COMPOSITION, GLYCEMIC CONTROL, AND WEIGHT MANAGEMENT.

TAS::89 0222::TAS FROM QUARKS TO THE COSMOS

PROMOTING THE SCHOOL READINESS SKILLS OF SPANISH-SPEAKING ENGLISH LEARNERS

SPECIAL EDUCATION RESEARCH

REGULATION OF PROLACTIN SECRETION AT THE LACTOTROPH

TOWARD A GLOBAL 1/25 DEGREE HYCOM OCEAN PREDICTION SYSTEM WITH TIDES

AN OPEN LEARNING DISABILITIES BEHAVIORAL DATA REPOSITORY

GENES UNDERLYING REPRODUCTIVE BEHAVIOR PHYSIOLOGY AND NEURONAL DEVELOPMENT - PROJECT SUMMARY/ABSTRACT TO UNDERSTAND MENTAL HEALTH AND DISEASE, WE NEED TO UNDERSTAND THE FUNCTION OF THE BRAIN AT THE LEVEL OF GENES, GENE REGULATORY NETWORKS, NEURONS, CIRCUIT STRUCTURE, AND PHYSIOLOGY. DROSOPHILA HAS EMERGED AS ONE OF THE MOST POWERFUL MODEL SYSTEMS FOR THESE QUESTIONS, GIVEN THE RANGE OF TOOLS AND THE TRACTABILITY OF ANALYZING COMPLEX BEHAVIORS AT ALL THESE LEVELS. THIS PROPOSAL SEEKS TO UNDERSTAND DROSOPHILA REPRODUCTIVE BEHAVIORS. ONE REASON DROSOPHILA IS SUCH A POWERFUL SYSTEM IS THAT THE SEX- SPECIFIC MASTER REGULATORY TRANSCRIPTION FACTORS THAT DIRECT REPRODUCTIVE BEHAVIORS ARE KNOWN. THIS HAS PROVIDED A POWERFUL MOLECULAR INROAD INTO IDENTIFYING AND MANIPULATING THE NEURONS THAT UNDERLIE THESE BEHAVIORS. THESE TOOLS CAN ALSO BE USED TO PERFORM NEURON-SPECIFIC MUTATIONAL STUDIES TO DISCOVER THE FUNCTIONS OF GENES THAT DIRECT BEHAVIORS, WHICH LEVERAGES ONE OF THE BIGGEST STRENGTHS OF THE DROSOPHILA MODEL SYSTEM. IN ADDITION, THIS SYSTEM AFFORDS AN UNPARALLELED MODEL TO BOTH EXAMINE THE SEX-SPECIFIC DEVELOPMENT OF THESE NEURONS AND HOW THEY ARE MODIFIED BY ADULT EXPERIENCES. RESEARCH USING THE DROSOPHILA MODEL HAS CONTINUED TO UNCOVER BIOLOGICALLY IMPORTANT PROCESSES THAT HAVE INFORMED ON HUMAN HEALTH AND DISEASE, INCLUDING STUDIES OF THE NERVOUS SYSTEM AND BEHAVIOR. THE WORK WILL BUILD OFF OF MY LABORATORIES 15-YEAR NIGMS FUNDED RESEARCH PROGRAM. WE WILL CONTINUE TO ADDRESS THESE BEHAVIORAL QUESTIONS USING CUTTING-EDGE MOLECULAR-GENETIC, GENOMIC, PROTEOMIC, BEHAVIORAL AND MICROSCOPY TOOLS TO GAIN INSIGHTS INTO COMPLEX BEHAVIORS.

UNIVERSITY TRANSPORTATION CENTER

MOLECULAR MECHANISM OF METABOLIC STRESS IN THE PANCREATIC BETA CELLS - TYPE 2 DIABETES (T2D) IS ONE OF THE MOST PREVALENT CHRONIC DISORDERS WITH A SUBSTANTIAL HEALTHCARE BURDEN. THE HALLMARK OF T2D IS BETA CELL DYSFUNCTION. HIGH GLUCOSE AND HIGH LIPID LEVELS (HEREIN REFERRED TO AS OVERNUTRITION) ARE THE TWO MOST SALIENT ENVIRONMENTAL RISK FACTORS ASSOCIATED WITH T2D. HOWEVER, THE SPECIFIC IMPACTS OF THESE FACTORS ON BETA CELLS, AS WELL AS THE MECHANISMS UNDERLYING SUCH IMPACTS, REMAIN UNCLEAR. ADDING TO THE COMPLEXITY IS THE OBSERVATION THAT BETA CELLS EXHIBIT BOTH ADAPTIVE AND MALADAPTIVE RESPONSES TO OVERNUTRITION, CONTINGENT ON THE DOSAGE AND DURATION OF EXPOSURE. THE GOAL OF THIS PROPOSED RESEARCH IS TO DETERMINE THE MOLECULAR MECHANISMS UNDERLYING BETA CELL OVERNUTRITION RESPONSE. OUR CENTRAL HYPOTHESIS IS THAT THE TRANSITION FROM GLUCOLIPOADAPTATION TO GLUCOLIPOTOXICITY IN BETA CELLS IS MEDIATED BY EPIGENETIC PROGRAMS. TO GAIN A DEEPER UNDERSTAND OF OVERNUTRITION-INDUCED BETA CELL STATE CHANGES, WE HAVE ESTABLISHED AN IN VITRO HUMAN BETA CELL METABOLIC STRESS MODEL. WE HAVE ALSO GENERATED SINGLE- CELL TRANSCRIPTOMIC MAPS FROM PRIMARY HUMAN PANCREATIC ISLETS EXPOSED TO METABOLIC STRESS AS WELL AS PHARMACOLOGICAL INDUCED ENDOPLASMIC RETICULUM STRESS. COMBINED WITH TARGETED DRUG SCREENING, WE IDENTIFIED HISTONE H3K9 METHYLTRANSFERASES G9A/GLP TO BE IMPORTANT MEDIATORS OF BETA CELL STRESS. BUILDING ON THESE FINDINGS, WE HAVE DEVELOPED TWO AIMS TO TRANSLATE THE LABORATORY DISCOVERY INTO MECHANISTIC BIOLOGICAL KNOWLEDGE OF T2D. IN AIM 1, WE WILL PERFORM A SERIES OF -OMIC ASSAYS WITH DENSE TIME COURSE TO DELINEATE THE MOLECULAR LANDSCAPE AND BETA CELL DYNAMIC STATE CHANGES IN RESPONSE TO OVERNUTRITION CHALLENGE. WE WILL CONNECT THE T2D VARIANTS IDENTIFIED BY GENOME-WIDE ASSOCIATION STUDIES WITH NUTRITION-RESPONSIVE CHROMATIN AND TRANSCRIPTOMIC CHANGES AND EXPERIMENTALLY ESTABLISH CAUSALITY BETWEEN VARIANTS TO FUNCTIONS IN BETA CELLS. IN AIM 2, WE WILL DISSECT THE MOLECULAR PATHWAYS LINKING OVERNUTRITION WITH G9A/GLP, AND BETA CELL CELLULAR MOLECULAR CHANGES. TOGETHER, OUR STUDY HAS SIGNIFICANT AND BROAD IMPACTS BY PROVIDING (1) NOVEL BIOLOGICAL MECHANISMS AND THERAPEUTIC TARGETS OF T2D; (2) A MOLECULAR NETWORK ENCOMPASSING EPIGENETIC REGULATORS, NUTRITION-RESPONSIVE CIS-REGULATORY ELEMENTS, AND THEIR GENETIC TARGETS IN HUMAN BETA CELLS THAT ENABLES INTERPRETING OF T2D PATHOGENESIS IN SIGNALING-DEPENDENT GENETIC PROGRAMS.

ENGAGEMENT AND COMMUNICATION BETWEEN PROTEASONAL SUBCOMPLEXES

TAS::57 3600::TAS 'A COMPREHENSIVE STUDY OF 3-D SHOCK/TURBULENT BOUNDARY LAYER INTERACTION PHYSICS: FLOW MORPHOLOGY AND SYSTEM DYNAMICS THROUGH'

CHEMICAL SYNTHESIS TO TRANSLATE FUSICOCCANES INTO PPI MODULATORS

MIDLIFE COGNITIVE AGING IN HISPANIC/LATINOS: PREDICTORS AND MECHANISMS OF DECLINE

UNKNOWN TITLE

THE HEALTH FOR HEARTS UNITED COLLABORATIVE - PROGRAM DIRECTOR/PRINCIPAL INVESTIGATOR (LAST, FIRST, MIDDLE): RALSTON, PENNY A. THE HEALTH FOR HEARTS UNITED COLLABORATIVE PROJECT SUMMARY CARDIOVASCULAR DISEASE (CVD) IS THE LEADING CAUSE OF DEATH IN THE UNITED STATES, AND DISPROPORTIONATELY AFFECTS AFRICAN AMERICANS (AAS) WHO HAVE THE HIGHEST RATES FOR CVD-RELATED MORBIDITY AND MORTALITY IN COMPARISON TO OTHER ETHNIC/RACIAL GROUPS. RISK FACTORS FOR THESE HIGH CVD RATES ARE RELATED TO A VARIETY OF FACTORS, INCLUDING LIFESTYLE. CHURCH-BASED INTERVENTIONS HAVE BEEN SHOWN TO BE EFFECTIVE IN IMPROVING PHYSICAL HEALTH OUTCOMES OF AAS. HOWEVER, A CRITICAL BARRIER TO ADVANCING THE SCIENCE OF CHURCH-BASED HEALTH IS UNDERSTANDING THE MOST EFFECTIVE STRATEGIES AND THE EXTENT TO WHICH EVIDENCE-BASED HEALTH PROGRAMS CAN BE IMPLEMENTED AND MAINTAINED BY CHURCHES THEMSELVES THE HEALTH FOR HEARTS UNITED COLLABORATIVE (HHUC), A COMMUNITY- ACADEMIC PARTNERSHIP COMPRISED OF 45 CHURCHES IN COLLABORATION WITH A BROADER MULTI-COUNTY HEALTH COALITION, WAS ESTABLISHED AFTER TWO SUCCESSFUL INTERVENTION STUDIES TO REDUCE CVD RISK IN AAS IN A TWO-COUNTY AREA OF NORTH FLORIDA, USING COMMUNITY-BASED PARTICIPATORY RESEARCH APPROACHES. WE NOW SEEK TO USE THIS COLLABORATIVE ENVIRONMENT TO INVESTIGATE IMPLEMENTATION OF THIS INTERVENTION BY THE CHURCHES THEMSELVES AS WE EXPAND THE HHUC. THUS, THE PROPOSED PROJECT WILL DETERMINE THE EFFECTIVENESS OF HHUC IMPLEMENTATION STRATEGIES IN RELATION TO PROCESS OUTCOMES AND REDUCING CVD RISK IN AAS, GUIDED BY ECOLOGICAL THEORY, THE CONSOLIDATED FRAMEWORK FOR IMPLEMENTATION RESEARCH (CFIR), AND THE RE-AIM FRAMEWORK, AND USING A TWO- PHASE APPROACH. THE HHUC MODEL CURRENTLY INCLUDES THREE COMPONENTS: GOVERNANCE STRUCTURE, ANNUAL EVENTS, AND BASIC SUPPORT. BASED ON OBSERVED SUCCESSES IN SELECTED HHUC CHURCHES, WE PROPOSE ADDING A FOURTH COMPONENT THAT INCLUDES ONE OF TWO POSSIBLE IMPLEMENTATION STRATEGIES: 1) AN INTERNAL CHAMPIONS (IC)-DRIVEN STRATEGY THAT INCLUDES TWO FEATURES (LEADERSHIP DEVELOPMENT, CULTURALLY-TAILORED PLANNING APPROACHES) OR 2) AN EXTERNAL CHANGE AGENT (EXTERNAL PROFESSIONALS [EP])-DRIVEN STRATEGY WITHOUT THESE FEATURES. IN PHASE 1, WE WILL PILOT AND REFINE THE IC AND EP-DRIVEN IMPLEMENTATION STRATEGIES USING HEALTH LEADERS FROM FOUR CHURCHES IN THE TWO-COUNTY AREA BY DETERMINING FEASIBILITY AND ACCEPTABILITY. IN PHASE 2, WE WILL USE AN EFFECTIVENESS- IMPLEMENTATION HYBRID TYPE 3 DESIGN TO EVALUATE THE IC AND EP IMPLEMENTATION STRATEGIES IN RELATION TO PROCESS OUTCOMES (REACH, ADOPTION, IMPLEMENTATION AND MAINTENANCE); AND INDIVIDUAL HEALTH BEHAVIORS (FOOD CHOICE, DIETARY QUALITY, PHYSICAL ACTIVITY) AND CLINICAL OUTCOMES (BMIS, GIRTH CIRCUMFERENCES, SYSTOLIC AND DIASTOLIC BLOOD PRESSURE), USING CONGREGANTS ((>18, N=225) IN NINE CHURCHES IN THE TWO-COUNTY AREA: THREE IC TREATMENT, THREE EP TREATMENT, AND THREE COMPARISON WITH DELAYED COMPARABLE ACTIVITIES. THE FINDINGS FROM THIS STUDY WILL INFORM THE EXPANSION OF THE HHUC AND THE REDUCTION OF CVD RISK IN AAS, WITH IMPLICATIONS FOR OTHER COMMUNITIES AND REGIONS IN THE U.S. OMB NO. 0925-0001/0002 (REV. 03/2020 APPROVED THROUGH 02/28/2023) PAGE CONTINUATION FORMAT PAGE

COLLABORATIVE RESEARCH: DIMES, DIAPYCNAL AND ISOPYCNAL MIXING IN THE SOUTHERN OCEAN

1/2-EFFECTS OF PARENT-IMPLEMENTED INTERVENTION FOR TODDLERS WITH AUTISM SPECTRUM

A MULTIDIMENSIONAL DIGITAL APPROACH TO ADDRESS VACCINE HESITANCY AND INCREASE COVID-19 VACCINE UPTAKE AMONG AFRICAN AMERICAN YOUNG ADULTS IN THE SOUTH - PROJECT SUMMARY YOUNG ADULTS (YA) ARE A KEY “SUPER-SPREADER” POPULATION TRANSMITTING SARS-CO-V2, THE CAUSATIVE AGENT OF COVID-19 (COVID). GIVEN THEIR HIGH RATE OF ASYMPTOMATIC INFECTION COMPOUNDED BY TRANSMISSION RATES THAT ARE BEING FUELED BY BEHAVIORS THAT RUN CONTRARY TO PHYSICAL DISTANCING AND FACE COVERING REGULATIONS, YA REPRESENT A PRIORITY POPULATION UPON WHICH TO FOCUS EFFORTS TO ENSURE HIGH LEVELS OF COVID VACCINE UPTAKE. WHILE COVID VACCINES CAN PROTECT AFRICAN AMERICAN YOUNG ADULTS (AA-YA) AGAINST COVID RELATED MORBIDITY AND MORTALITY, THIS POPULATION WILL ONLY ACCEPT VACCINATION IF INTERVENTIONS ASSURE AA-YA OF ITS SAFETY AND BENEFIT, WHILE ALSO ADDRESSING HISTORICAL CONTEXTS AND SYSTEMIC FORCES THAT PROPAGATE MISTRUST. DIGITAL HEALTH INTERVENTIONS (DHIS) CAN REACH LARGE NUMBERS OF AA-YA REGARDLESS OF GEOGRAPHIC LOCATION AND EMPOWER THEM TO MAKE INFORMED DECISIONS ABOUT THEIR HEALTH USING A FAMILIAR MODALITY THAT YAS VALUE AND TRUST. OUR COLLABORATIVE TEAM DEVELOPED THE THEORY INFORMED DHI TOUGH TALKS TO ASSIST YA WITH HIV DISCLOSURE DECISION MAKING, SPECIFICALLY BY CONSIDERING THE SOCIAL, ETHICAL AND BEHAVIORAL IMPLICATIONS OF THEIR CHOICES AND THE CONSEQUENCES THAT FOLLOW. IN RESPONSE TO NOT-MD-21-008: RESEARCH TO ADDRESS VACCINE HESITANCY, UPTAKE, AND IMPLEMENTATION AMONG POPULATIONS THAT EXPERIENCE HEALTH DISPARITIES, WE PROPOSE TO APPLY A COMMUNITY- BASED PARTICIPATORY RESEARCH (CBPR) APPROACH TO ASSESS MULTI-LEVEL FACTORS IDENTIFIED WITHIN THE NIMHD RESEARCH FRAMEWORK AND ADAPT AND TEST TOUGH TALKS TO ADDRESS COVID VACCINE HESITANCY (VH), TOUGH TALKS-COVID (TT-C). IN AIM 1, WE WILL CONDUCT MULTI-METHOD FORMATIVE RESEARCH TO ELICIT THE BEHAVIORAL, COGNITIVE, AND ENVIRONMENTAL DETERMINANTS INFLUENCING COVID VH AMONG AA-YA (AGES 18-29) IN THREE SOUTHERN STATES. WE COMBINE VALIDATED SURVEY MEASURES, WITH NOVEL CBPR METHODS INCLUDING CHOOSE-YOUR- OWN ADVENTURE JOURNEYS AND DIGITAL STORYTELLING TO BETTER UNDERSTAND VACCINE DECISION-MAKING IN AA-YA. IN COLLABORATION WITH EXPERT ADVISORS, COMMUNITY PARTNERS, AND AA-YA END-USERS, IN AIM 2, WE WILL LEVERAGE ADAPT-ITT TO DEVELOP AND REFINE TT-C. USER-CENTERED PARTICIPATORY DESIGN AND RAPID PROTOTYPING FOCUS GROUPS WILL BE CONDUCTED WITH AA-YA (N=12-16) IN SOUTHERN STATES. ONCE FINALIZED, WE WILL CONDUCT A TECHNICAL PILOT WITH AA-YA (N=24) TO ASSESS TT-C’S FEASIBILITY AND ACCEPTABILITY. IN AIM 3, WE WILL CONDUCT A HYBRID TYPE 1 EFFECTIVENESS IMPLEMENTATION 3-ARM RCT WITH N=540 AA-YA FROM THREE SOUTHERN STATES. PARTICIPANTS WILL BE RANDOMIZED TO RECEIVE STANDARD OF CARE (CONTROL), TT-C DELIVERED REMOTELY, AND TT-C DELIVERED IN-PERSON. PRIMARY EFFECTIVENESS OUTCOMES ARE COVID VACCINE UPTAKE AND SERIES COMPLETION. SECONDARY EFFECTIVENESS OUTCOMES ARE VH, CONFIDENCE, AND KNOWLEDGE, ATTITUDES AND BELIEFS. WE WILL CONDUCT QUALITATIVE INTERVIEWS WITH PARTICIPANTS (N=12-16) AND SITE STAFF (N=6-8) TO ASSESS IMPLEMENTATION BARRIERS AND FACILITATORS. WE LEVERAGE OUR EXISTING INFRASTRUCTURE TO MEANINGFULLY ENGAGE WITH SOUTHERN AA-YA COMMUNITIES, WORKING TO DISMANTLE INEQUITABLE RESEARCH RELATIONSHIPS AND MEDICAL MISTRUST TO INCREASE COVID VACCINE UPTAKE.

DEVELOP A PROGRAM TO PROVIDE INNOVATIVE NEW APPROACHES FOR CONDUCTING SYSTEMATIC INTERDISCIPLINARY HISTORICALLY-BASED RESEARCH AND ANALYSES RELATING TO UNRESOLVED CASUALTY CASES.

CURATION OF NATIONAL ANTARCTIC MARINE SEDIMENT COLLECTIONS

CORRELATIONS: STRUCTURE-DYNAMICS-FUNCTIONS IN CHANNELS

DESIGN AND INTEGRATION OF THE 21 TESLA (T) MAGNET

SCHOLARSHIPS FOR SERVICE FOR FSU MS CC AND CNSA STUDENTS

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

INTEGRATED CRYO-COOLED HIGH POWER DENSITY TEST BED AND DC CABLE SYSTEM

ELECTROMECHANICAL STUDIES OF SUPERCONDUCTORS FOR DOE/HEP APPLICATIONS

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

CLIMATE FORECASTING FOR FLORIDA: DECISION SUPPORT SYSTEM FOR REDUCING AGRICULTURAL RISKS CAUSED BY SEASONAL & LONGER-TERM CLIMATE VARIABILIT

INVESTING IN INNOVATION- DEVELOPMENT

NEURAL BASES OF CEPHALIC PHASE ENDOCRINE RESPONSES

SMART EARLY SCREENING FOR AUTISM AND COMMUNICATION DISORDERS IN PRIMARY CARE

TAS::89 0227::TAS RECOVERY ACT - HIGH ENERGY PHYSICS

INTERTRIBAL TALKING CIRCLE FOR THE PREVENTION OF SUBSTANCE ABUSE IN NATIVE YOUTH

CRYOEM STUDIES OF MUSCLE - PROJECT SUMMARY THE LONG TERM GOAL OF THIS RESEARCH PROJECT HAS BEEN AND CONTINUES TO BE AN UNDERSTANDING OF THE MOLECULAR MECHANISM OF MUSCLE FUNCTION. THE EXISTING PROJECT, FUNDED CONTINUOUSLY SINCE 1983, HAS EVOLVED IN PARALLEL WITH THE CAPABILITIES OF BOTH MICROSCOPES AND METHODS FOR 3-D IMAGE RECONSTRUCTION FROM ELECTRON MICROSCOPES. ORIGINALLY FOCUSED ON UNDERSTANDING MYOSIN-ACTIN INTERACTIONS IN SITU IN MUSCLE USING CHEMICALLY FIXED, PLASTIC EMBEDDED AND SECTIONED MUSCLE, IT NOW PROPOSES TO TAKE ADVANTAGE OF THE RESOLUTION REVOLUTION IN CRYOEM TO STUDY THE MAJOR STRUCTURAL ELEMENTS OF THE MUSCLE AT THE HIGHEST RESOLUTION POSSIBLE USING ISOLATED COMPONENTS, FOLLOWED BY A RETURN TO IMAGING ACTIN-MYOSIN INTERACTIONS IN SITU IN FROZEN LIVE MUSCLE CELLS. STRIATED MUSCLES HAVE FOUR MAJOR COMPONENTS: ACTIN-CONTAINING THIN FILAMENTS, MYOSIN- CONTAINING THICK FILAMENTS, A Z-DISK TO CROSSLINK ANTIPARALLEL THIN FILAMENTS AND A CONNECTING FILAMENT TO LINK THE THICK FILAMENTS TO THE Z-DISK. THE LEAST UNDERSTOOD OF THESE FOUR ELEMENTS ARE THE THICK FILAMENT, THE Z-DISK AND THE CONNECTING FILAMENT, WHOSE INTERACTIONS WITH THE THICK FILAMENT AND Z-DISK ARE ITS LEAST UNDERSTOOD ELEMENTS. THUS, OUR STUDY OF Z-DISK AND THICK FILAMENT CAN MAKE MAJOR CONTRIBUTIONS TO AN UNDERSTANDING OF ALL THREE ELEMENTS. FOLLOWING A MAJOR BREAKTHROUGH OF OURS THAT SHOWED THAT COILED-COIL TAIL DOMAIN OF MYOSIN CAN BE IMAGED AT SUBNANOMETER RESOLUTION, EVEN NEAR ATOMIC RESOLUTION, THE PROJECT CONCENTRATES INITIALLY ON SUBNANOMETER RESOLUTION IMAGING OF THICK FILAMENTS FROM SEVERAL SPECIES, TO EXAMINE THE GENERALITY AND STRUCTURAL CONSERVATION OF THE “CURVED MOLECULAR CRYSTALLINE LAYERS” ACROSS SPECIES AND MUSCLE TYPES. THE PROJECT WILL UTILIZE THE FRUIT FLY, DROSOPHILA MELANOGASTER, TO INVESTIGATE HOW GENETIC REMOVAL OF CERTAIN COMPONENT PROTEINS AFFECTS HOW THE MYOSIN TAILS INTERACT WITH NON-MYOSIN PROTEINS TO AFFECT THICK FILAMENT PROPERTIES. WE WILL UTILIZE MUTATIONS IN THE MYOSIN TAIL OF DROSOPHILA THAT CORRESPOND TO ESTABLISHED DISEASE CAUSING MUTATIONS IN HUMAN STRIATED MUSCLE. THE Z-DISK WILL BE STUDIED USING METHODOLOGY DEVELOPED IN OUR LAB TO ISOLATE Z-DISKS FROM INVERTEBRATES APPLIED TO DETERMINATION OF THE DROSOPHILA MELANOGASTER Z-DISK. THE EXPERIMENTAL SYSTEM WILL FACILITATE DECORATION OF THE Z-DISKS WITH VARIOUS SIGNALING PROTEINS. ULTIMATELY, THE UTILITY OF THESE STUDIES ON COMPONENTS NEEDS DEVELOPMENT WITHIN THE MYOFIBRIL. WE WILL INVESTIGATE BY CRYOELECTRON TOMOGRAPHY FROZEN-HYDRATED MYOFIBRILS OF LETHOCERUS AND DROSOPHILA THINNED USING FIB/SEM IN STATES PRODUCED USING VARIOUS NUCLEOTIDES TO SEE HOW MYOSIN HEADS INTERACT WITH THE THIN FILAMENT IN SITU. ULTIMATELY, WE WILL APPLY WHAT WE HAVE LEARNED METHODOLOGICALLY FROM THESE MYOFIBRIL STUDIES TO STUDIES OF LIVE CULTURED SMOOTH AND CARDIAC MUSCLE CELLS FAST FROZEN, THINNED VIA FIB/SEM TO VISUALIZE ACTIVE INTERACTIONS BETWEEN THICK AND THIN FILAMENTS. THIS WORK WILL OPEN TO FUTURE STRUCTURAL INVESTIGATION ALL THE STRUCTURES PRESENT IN A MUSCLE CELL WITHIN THEIR NATURAL CONTEXT.

TRAUMA IN YOUNG CHILDREN FROM MIGRANT FARM WORKING FAMILIES

CORTICAL-HIPPOCAMPAL BRAIN DYNAMICS DURING SLEEP FOLLOWING SPATIAL LEARNING IN RODENTS MODELING TAU AND AB AGGREGATION FEATURE OF ALZHEIMER'S DISEASE - PROJECT SUMMARY/ABSTRACT ALZHEIMER’S DISEASE IS DEVASTATING FOR INDIVIDUALS AND SOCIETY. IMPAIRED LEARNING AND MEMORY, PARTICULARLY IN THE CONTEXT OF SPATIAL NAVIGATION, IS ONE OF ITS EARLY AND MAJOR SYMPTOMS. SIMILARLY, RODENTS RECAPITULATING ASPECTS OF ALZHEIMER’S DISEASE ALSO EXHIBIT EARLY IMPAIRMENTS IN SPATIAL NAVIGATION. A PREPONDERANCE OF EVIDENCE SUGGESTS ABNORMAL CORTICAL-HIPPOCAMPAL COMMUNICATION IN HUMANS WITH ALZHEIMER’S DISEASE. HIPPOCAMPAL-CORTICAL INTERACTIONS DURING SLEEP ARE THOUGHT TO BE CRITICAL FOR CONSOLIDATION OF NEWLY ACQUIRED MEMORIES. HOWEVER, NO STUDIES HAVE ASSESSED THESE BRAIN DYNAMICS DURING SLEEP IN RODENTS MODELING TAU AND AMYLOID BETA (ASS) AGGREGATION ASPECTS OF ALZHEIMER’S DISEASE. THUS, THE PROPOSED RESEARCH WILL EXPLORE THE FUNCTIONALITY OF BRAIN DYNAMICS DURING SLEEP IN THE HIPPOCAMPAL-PC NETWORK IN ANIMAL MODELS OF TAU AND ASS AGGREGATION (TASSA). TO DO THIS, WE WILL USE A TRIPLE TRANSGENIC MOUSE WHERE THREE MAJOR GENES ASSOCIATED WITH FAMILIAL ALZHEIMER’S DISEASE ARE EXPRESSED LEADING TO TASSA. THIS MOUSE MODEL MIMICS PLAQUE AND TANGLE PATHOLOGICAL HALLMARKS OF THE DISEASE, WITH A DISTRIBUTION PATTERN SIMILAR TO HUMAN PATIENTS, INCLUDING SYNAPTIC CHANGES IN THE LIMBIC SYSTEM. IN ADDITION, ALL FINDINGS WILL BE CONFIRMED IN A TRANSGENIC RAT WITH ASS ACCUMULATION, PLAQUE FORMATION, TAU ACCUMULATION, CELL LOSS, AND SPATIAL MEMORY IMPAIRMENTS. SPECIFICALLY, WE WILL: 1) ASSESS THE RELATIONSHIP BETWEEN SPATIAL LEARNING AND MEMORY, AS WELL AS BRAIN DYNAMICS DURING SLEEP, BOTH WITHIN AND ACROSS THE HIPPOCAMPUS AND CORTEX; 2) USE A NOVEL TARGETED OPTOGENETIC APPROACH TO FUNCTIONALLY DISSECT THE RELATIVE CONTRIBUTIONS OF TASSA IN THE HIPPOCAMPUS TO IMPAIRED HIPPOCAMPAL-CORTICAL COUPLING DURING SLEEP AND IMPAIRED SPATIAL LEARNING. 3) TEST THE EFFICACY OF A NON-INVASIVE VISUAL STIMULATION APPROACH, KNOWN FOR CLEARING CORTICAL TASSA, TO RELIEVE IMPAIRED HIPPOCAMPAL-CORTICAL COUPLING DURING SLEEP AND IMPAIRED SPATIAL LEARNING. THIS PROJECT WILL PROVIDE INSIGHT INTO THE NORMAL FUNCTION OF A CIRCUIT THAT IS DYSFUNCTIONAL IN ALZHEIMER’S DISEASE AND ALLOW US TO PROBE DYSFUNCTION IN THIS CIRCUIT THAT EMERGES IN VERY EARLY STAGES OF DISEASE PROGRESSION IN RODENTS MODELING TASSA ASPECTS OF ALZHEIMER’S DISEASE. THIS RESEARCH WILL ALLOW US TO BEGIN UNDERSTANDING CHANGES IN THIS NETWORK WHICH MAY UNDERLIE THE EMERGENCE OF COGNITIVE IMPAIRMENTS OBSERVED IN ALZHEIMER’S DISEASE AND BEGIN TESTING THE EFFICACY OF A NON-INVASIVE TREATMENT FOR REVERSING THE FUNCTIONAL BRAIN ABNORMALITIES AND IMPAIRED COGNITION.

ASSESSING THE LINKS BETWEEN RISK FACTORS, COVID-19 IMPACTS, AND READING SKILLS - PROJECT SUMMARY THE COVID-19 PANDEMIC HAS PRESENTED A SUDDEN YET PERSISTING SET OF STRESSORS FOR CHILDREN ACROSS THE U.S., THAT HAVE HAD FAR-REACHING IMPACTS ON THEIR WELLBEING, HEALTH, AND ACADEMIC OUTCOMES. THE COVID-19 PANDEMIC BROUGHT ABOUT AN UNPRECEDENTED NUMBER OF SCHOOL CLOSURES THAT HAVE IMPACTED LEARNING FOR NEARLY 78 MILLION CHILDREN (UNESCO, 2021). LEARNING TO READ IS CRUCIAL, AS READING IS A CRITICAL INDICATOR OF LIFETIME EARNINGS, GENERAL HEALTH, AND WELLBEING (OECD, 2012). BEFORE THE PANDEMIC, MANY CHILDREN WERE ALREADY AT RISK FOR READING DIFFICULTIES, WITH ONLY 35% OF U.S. FOURTH GRADERS SHOWING PROFICIENT LEVELS OF READING ABILITY (NCES, 2019). THESE READING DIFFICULTIES HAVE ONLY BEEN MAGNIFIED BY COVID-19 RELATED IMPACTS. DATA FROM THE 2020-2021 SCHOOL YEAR SHOWS THAT CHILDREN’S READING SCORES GOT WORSE, WITH AVERAGE END OF YEAR READING SCORES 3 TO 6 PERCENTILE POINTS LOWER THAN PRE-PANDEMIC LEVELS (LEWIS ET AL., 2021). THE OVERALL GOAL OF THIS PROJECT IS TO UNCOVER THE MECHANISMS THROUGH WHICH COVID-19 HAS AND WILL HAVE SHORT-TERM AND LONG-TERM IMPACTS ON CHILDREN’S READING SKILLS. WE USE A RISK-RESILIENCE MODEL AS THE FRAMEWORK FOR THIS PROJECT, WHICH RECOGNIZES CHILDREN HAVE VARYING LEVELS OF RISK FACTORS THAT MAKE THEM MORE OR LESS LIKELY TO BE AFFECTED BY COVID-19 RELATED DISRUPTIONS TO THEIR SOURCES OF RESILIENCY. WE WILL CAPITALIZE ON AN EXISTING ACTIVE NATIONAL TWIN PROJECT, THE NATIONAL PROJECT ON ACHIEVEMENT IN TWINS (NATPAT). NATPAT HAS ALREADY ENROLLED A COHORT OF 1801 PAIRS OF TWINS (AND GROWING) AND HAS BEEN TRACKING THEM AS THEY PROGRESS THROUGH ELEMENTARY SCHOOL, COLLECTING THEIR READING PROGRESS MONITORING DATA THREE TIMES A YEAR. WE WILL CONTINUE TO ENROLL TWINS INTO NATPAT USING OUR SUCCESSFUL AND ESTABLISHED RECRUITMENT PROCEDURES, AND COLLECT THEIR ONGOING READING DATA. IN ADDITION, EVERY SUMMER FOR ALL FIVE YEARS OF THE GRANT, ANY TWIN FAMILY WITH CHILDREN IN GRADES KINDERGARTEN TO 6 WILL BE MAILED A SURVEY PACKET TO THEIR HOMES. THIS PACKET WILL CONTAIN A PARENT AND CHILD SURVEY WITH QUESTIONNAIRES RELATED TO THEIR EXPERIENCES OVER THE LAST SCHOOL YEAR RELATED TO COVID-19 IMPACTS, SPECIFICALLY THEIR SOCIAL INTERACTIONS, HEALTH AND ECONOMIC STATUS AND CHANGES, AND THEIR EXPERIENCES WITH DIGITAL TECHNOLOGY. USING METHODS THAT ALLOW US TO UNDERSTAND CAUSAL RELATIONS, WE ARE UNIQUELY SITUATED TO ADDRESS THE OVERALL GOAL OF THE PROPOSED RESEARCH THROUGH THREE SPECIFIC AIMS (SA). FIRST, WE WILL QUANTIFY THE SHORT AND LONG-TERM EFFECTS THAT LOSING SOCIAL RESOURCES DUE TO COVID-19 HAS ON READING SKILLS (SA1). SECOND, WE WILL QUANTIFY THE SHORT AND LONG-TERM EFFECTS OF COVID-19 RELATED HEALTH AND ECONOMIC STRESSORS ON READING SKILLS (SA2). FINALLY, WE WILL QUANTIFY THE SHORT AND LONG-TERM EFFECTS OF THE DIGITAL-DIVIDE ON READING SKILLS DURING COVID-19 (SA3).

THEORY OF PROTEIN-PROTEIN ASSOCIATION

DECISION SUPPORT SYSTEM FOR REDUCING AGRICULTURAL RISKS CAUSED BY CLIMATE VARIABILITY

DECISION SUPPORT SYSTEM FOR REDUCING AGRICULTURAL RISKS CAUSED BY CLIMATE VARIABILITY

DOPAMINE REGULATION OF SOCIAL ATTACHMENT

FIRE: AN INTEGRATED AI SYSTEM TACKLING THE FULL LIFE CYCLE OF WILDFIRES IN HURRICANE PRONE REGIONS -WILDFIRE MANAGEMENT IN THE FLORIDA PANHANDLE FACES UNPRECEDENTED CHALLENGES DUE TO THE UNIQUE INTERACTION BETWEEN HURRICANES AND FIRE BEHAVIOR. THIS FIRE-DEPENDENT ECOSYSTEM RELIES ON REGULAR WILDFIRE FOR ECOLOGICAL HEALTH, YET HURRICANE DISTURBANCES CAN DRAMATICALLY ALTER THIS NATURAL BALANCE BY CREATING MASSIVE FUEL ACCUMULATIONS THAT TRANSFORM BENEFICIAL FIRES INTO DEVASTATING THREATS TO RURAL COMMUNITIES. UNLIKE OTHER FIRE-PRONE REGIONS, THE FLORIDA PANHANDLE EXPERIENCES HURRICANE DISTURBANCES THAT CAN INCREASE FUEL LOADS BY AN ORDER OF MAGNITUDE, CREATING CONDITIONS WHERE ECOLOGICALLY NECESSARY FIRES BECOME UNCONTROLLABLE DISASTERS. CURRENT WILDFIRE MANAGEMENT APPROACHES USUALLY DO NOT ACCOUNT FOR THESE HURRICANE-FIRE INTERACTIONS, LEAVING COMMUNITIES VULNERABLE DURING EVACUATION AND RECOVERY. THIS RESEARCH WILL DEVELOP THE FIRST COMPREHENSIVE ARTIFICIAL INTELLIGENCE SYSTEM SPECIFICALLY DESIGNED TO ADDRESS HURRICANE-FUELED WILDFIRE DYNAMICS THROUGHOUT THE COMPLETE WILDFIRE LIFECYCLE. THE PROJECT WILL ENHANCE COMMUNITY RESILIENCE BY PROVIDING EMERGENCY MANAGERS WITH PREDICTIVE TOOLS FOR FUEL ACCUMULATION, REAL-TIME ROADWAY MONITORING DURING EVACUATIONS, AND AUTOMATED INFRASTRUCTURE DAMAGE ASSESSMENT. THE RESEARCH INCLUDES WORKFORCE TRAINING FOR EMERGENCY PERSONNEL AND COMMUNITY-CENTERED EDUCATIONAL PROGRAMS. THE OPEN-SOURCE SYSTEM WILL BE DEPLOYABLE ACROSS THE HURRICANE-AFFECTED SOUTHEASTERN UNITED STATES, POTENTIALLY TRANSFORMING WILDFIRE RISK MANAGEMENT FOR MILLIONS OF RESIDENTS WHILE ESTABLISHING NEW STANDARDS FOR INTERDISCIPLINARY DISASTER SCIENCE. THIS PROJECT DEVELOPS AN INTEGRATED ARTIFICIAL INTELLIGENCE SYSTEM THAT ADDRESSES THE FULL LIFECYCLE OF HURRICANE-FUELED WILDFIRE THROUGH FOUR INTERCONNECTED RESEARCH THRUSTS. THE FIRST THRUST CREATES PRE-WILDFIRE CAPABILITIES USING SPATIAL-TEMPORAL GRAPH NEURAL NETWORKS TO MODEL HURRICANE-DRIVEN FUEL DYNAMICS AND PHYSICS-INFORMED LEARNING FOR IGNITION FORECASTING. THE SECOND THRUST ADVANCES IN-WILDFIRE RESPONSE THROUGH AI-ENHANCED ROADWAY DISRUPTION PREDICTION AND REAL-TIME EVACUATION SUPPORT USING CROWD-SOURCED OBSERVATIONS. THE THIRD THRUST ESTABLISHES POST-WILDFIRE ASSESSMENT CAPABILITIES USING MULTIMODAL FOUNDATION MODELS FOR INFRASTRUCTURE DAMAGE EVALUATION AND FUEL-ECOSYSTEM RECOVERY MODELING. THE FOURTH THRUST DEVELOPS COMPREHENSIVE WORKFORCE TRAINING AND COMMUNITY-CENTERED EDUCATIONAL OUTREACH TO ENSURE OPERATIONAL FEASIBILITY. THE RESEARCH LEVERAGES PARTNERSHIPS WITH LOCAL STAKEHOLDERS IN THE FLORIDA PANHANDLE TO ACCESS FIELD DATA AND PERFORM IMPLEMENTATION. RESEARCH OUTCOME CAN BE WIDELY DISSEMINATED THROUGH DEPLOYABLE TOOLS, EDUCATIONAL MODULES, AND COMMUNITY PARTNERSHIPS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

SUPPORTING TEACHER ENACTMENT OF THE PROBABILITY AND STATISTICS STANDARDS—REPLICATION

THREE DIMENSIONAL CHROMOSOME ARCHITECTURE IN DRUG ADDICTION

A MECHANISTIC AND DYADIC APPROACH TO IDENTIFY HOW INTERPERSONAL CONSCIENTIOUSNESS SUPPORTS COGNITIVE HEALTH AND LOWERS RISK OF DEMENTIA - PROJECT SUMMARY THE BURDEN OF ALZHEIMER’S DISEASE (AD) TAKES A SIGNIFICANT TOLL ON THE INDIVIDUAL LIVING WITH DEMENTIA, THEIR FAMILIES AND COMMUNITIES, AND THE HEALTHCARE SYSTEM. WITHOUT EFFECTIVE INTERVENTION AND PREVENTION STRATEGIES, THE PREVALENCE OF AD IS EXPECTED TO MORE THAN DOUBLE OVER THE NEXT 30 YEARS. IT IS CRITICAL TO IDENTIFY PROTECTIVE FACTORS THAT CAN BE LEVERAGED FOR MORE EFFECTIVE PREVENTION BEFORE THE ONSET OF THE DISEASE. CONSCIENTIOUSNESS IS A PERSONALITY TRAIT THAT IS ASSOCIATED CONSISTENTLY WITH BETTER HEALTH OUTCOMES, WHICH EXTENDS TO DEMENTIA: CONSCIENTIOUSNESS IS ONE OF THE MOST REPLICATED PSYCHOLOGICAL FACTORS THAT IS PROTECTIVE AGAINST COGNITIVE IMPAIRMENT. MOST WORK ON CONSCIENTIOUSNESS HAS FOCUSED ON ITS AGENTIC ASPECTS (E.G., SELF-CONTROL, ACHIEVEMENT STRIVING). CONSCIENTIOUSNESS, HOWEVER, HAS A DISTINCT INTERPERSONAL COMPONENT THAT IS OFTEN OVERLOOKED IN THE RELATION WITH HEALTH IN GENERAL AND COGNITION IN PARTICULAR. THIS INTERPERSONAL COMPONENT – INTERPERSONAL CONSCIENTIOUSNESS – DEFINED AS EITHER RESPONSIBILITY OR DUTIFULNESS, IS PROTECTIVE AGAINST DEMENTIA, AN EFFECT THAT HAS REPLICATED IN THREE INDEPENDENT SAMPLES. IN ADDITION, ITS PROTECTIVE ASSOCIATION WITH DEMENTIA IS INDEPENDENT OF THE AGENTIC COMPONENTS OF THIS TRAIT AND EXTENDS TO COGNITIVE FUNCTION PRIOR TO DEMENTIA. INTERPERSONAL CONSCIENTIOUSNESS IS THUS A ROBUST AND NOVEL PSYCHOLOGICAL FACTOR THAT IS A PROMISING TARGET OF INTERVENTION FOR HEALTHIER COGNITIVE OUTCOMES IN OLDER ADULTHOOD. THE OBJECTIVE OF THIS PROPOSAL IS TO PROVIDE MUCH NEEDED STAGE 0 EVIDENCE THAT IS NECESSARY FOR INTERVENTION DEVELOPMENT. SPECIFICALLY, THIS RESEARCH AIMS TO IDENTIFY THE CLINICAL/PHYSIOLOGICAL, BEHAVIORAL, PSYCHOLOGICAL, AND RELATIONAL MECHANISMS THROUGH WHICH INTERPERSONAL CONSCIENTIOUSNESS LEADS TO BETTER COGNITIVE OUTCOMES. THE PROPOSED RESEARCH ADDRESSES THESE MECHANISMS AND COGNITION AS TYPICALLY MEASURED IN LAB SETTINGS AND THE DAILY EXPRESSION OF THESE MECHANISMS AND MOMENTARY COGNITIVE PERFORMANCE MEASURED WITH ECOLOGICAL MOMENTARY ASSESSMENT IN EVERYDAY LIFE. IT SEEKS TO IDENTIFY THE PATHWAYS THROUGH WHICH INTERPERSONAL CONSCIENTIOUSNESS PROTECTS COGNITION AND PROMOTES BETTER DAILY COGNITIVE FUNCTION ACROSS A CRITICAL PERIOD OF THE LIFESPAN – MIDLIFE AND THE TRANSITION TO OLD AGE (AGES 40-70) – A PERIOD PARTICULARLY RELEVANT FOR PREVENTION BECAUSE IT IS GENERALLY BEFORE THE ONSET OF NEURODEGENERATION. IN ADDITION, THIS RESEARCH ADDRESSES ACTOR AND PARTNER EFFECTS WITHIN COMMITTED RELATIONSHIPS TO TEST WHETHER THE PROTECTIVE EFFECT OF INTERPERSONAL CONSCIENTIOUSNESS EXTENDS FROM ONE MEMBER OF THE COUPLE TO THE OTHER. THIS WORK WILL LEAD TO NEW KNOWLEDGE ON HOW INTERPERSONAL CONSCIENTIOUSNESS PROMOTES HEALTHIER COGNITIVE AGING AND WILL POINT TO NEW PREVENTION AND INTERVENTION TARGETS FOR PROMOTING HEALTHIER COGNITIVE AGING ACROSS ADULTHOOD TO SUPPORT BETTER OUTCOMES IN OLDER ADULTHOOD.

FSU/USGS COOPERATIVE RESEARCH PROGRAM

UNRAVELING THE MYSTERIES OF THE PLATINUM GROUP ELEMENTS

PRENATAL AND EARLY LIFE ANTECEDENTS OF PERSONALITY: AN INTERGENERATIONAL LIFESPAN APPROACH - PROJECT SUMMARY ALZHEIMER’S DISEASE IS PREVALENT AT THE END OF LIFE AND REMAINS THE ONLY LEADING CAUSE OF DEATH WITHOUT A CURE OR WAY TO STOP OR SIGNIFICANTLY SLOW ITS PROGRESSION. PREVENTION REMAINS THE BEST HOPE FOR REDUCING RISK OF ALZHEIMER’S DISEASE IN OLDER ADULTHOOD. GIVEN THAT ALZHEIMER’S DISEASE HAS A COMPLEX ETIOLOGY, WITH RISK FACTORS THAT RANGE FROM GENETICS TO THE ENVIRONMENT, MULTIPRONGED APPROACHES TO PREVENTION WILL LIKELY BE NEEDED FOR AN INTERVENTION TO BE BROADLY EFFECTIVE. AMONG THE PSYCHOSOCIAL RISK FACTORS FOR ALZHEIMER’S DISEASE, PERSONALITY TRAITS HAVE EMERGED AS CONSISTENT PREDICTORS OF COGNITIVE HEALTH ACROSS ADULTHOOD. SPECIFICALLY, HIGHER NEUROTICISM (THE TENDENCY TO EXPERIENCE NEGATIVE EMOTIONS AND VULNERABILITY TO STRESS) AND LOWER CONSCIENTIOUSNESS (THE TENDENCY TO BE ORGANIZED, DISCIPLINED, AND RESPONSIBLE) ARE ASSOCIATED WITH WORSE PERFORMANCE ON COGNITIVE TASKS, MORE SUBJECTIVE COGNITIVE COMPLAINTS, AND GREATER RISK OF ALZHEIMER’S DISEASE AND RELATED DEMENTIAS. EVEN AFTER DIAGNOSIS, THESE TRAITS ARE ASSOCIATED WITH BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS AT THE END OF LIFE. LIFESPAN MODELS OF PERSONALITY AND HEALTH INDICATE THAT PERSONALITY CONTRIBUTES TO LONG-TERM HEALTH OUTCOMES THROUGH BOTH BEHAVIORAL AND CLINICAL PATHWAYS. MISSING FROM THESE MODELS, HOWEVER, ARE THE ANTECEDENTS OF PERSONALITY, NOVEL MECHANISMS THAT GO BEYOND BEHAVIORAL AND CLINICAL RISK FACTORS, AND HOW INFORMANT RATINGS OF PERSONALITY AND COGNITION PROVIDE UNIQUE INFORMATION ABOUT THE TARGET’S COGNITIVE HEALTH. THIS WORK BUILDS ON THE SUCCESS OF OUR PREVIOUS AWARD THAT FOUND THAT PERSONALITY IS SHAPED BY SOCIOECONOMIC FACTORS AND THAT PERSONALITY IS ONE MECHANISM IN THE PATHWAY FROM CHILDHOOD SOCIOECONOMIC STATUS TO ADULT COGNITIVE HEALTH. THE PURPOSE OF THIS PROJECT IS TO EXPAND CONSIDERATION OF ADVANTAGES AND DISADVANTAGES EXPERIENCED ACROSS THE LIFESPAN TO INCLUDE OTHER DOMAINS, INCLUDING STRUCTURAL AND ENVIRONMENTAL ADVANTAGES AND DISADVANTAGES, TO BETTER UNDERSTAND HOW THE ACCUMULATION AND INTERPLAY OF SUCH FACTORS ACROSS CHILDHOOD AND ADULTHOOD SHAPE ADULT PERSONALITY TRAITS. THIS PROJECT WILL FURTHER EVALUATE SOCIOEMOTIONAL HEALTH AND BEHAVIORAL LIFE SKILLS AS NOVEL PATHWAYS FROM PERSONALITY TO COGNITIVE HEALTH, WHICH ARE HYPOTHESIZED TO BE MECHANISMS THAT GO BEYOND TRADITIONAL BEHAVIORAL AND CLINICAL RISK FACTORS. FINALLY, THIS PROJECT WILL ALSO INCLUDE INFORMANT RATINGS OF PERSONALITY AND COGNITION AS AN ADDITIONAL SOURCE OF INFORMATION THAT PROVIDES UNIQUE INFORMATION ABOUT THE TARGET’S HEALTH. WE WILL ADDRESS THESE AIMS IN AN ONGOING LONGITUDINAL COHORT STUDY WITH A RACIALLY AND SOCIOECONOMICALLY DIVERSE SAMPLE. THE ULTIMATE GOAL OF THIS WORK IS TO DEVELOP A PERSONALITY-INFORMED INTERVENTION TO SUPPORT HEALTHIER COGNITIVE AGING AND REDUCE RISK OF ALZHEIMER’S DISEASE. WE SEEK TO BUILD A ROBUST AND REPLICABLE EVIDENCE BASE FOR A LIFESPAN MODEL OF PERSONALITY AND COGNITIVE HEALTH THAT INCLUDES ANTECEDENTS OF PERSONALITY AND MECHANISMS IN THIS PATHWAY AS A STEP TOWARD THIS GOAL.

UNIFIED UNIVERSAL CONTROL AND COORDINATION OF INVERTER-BASED RESOURCES, AND VALIDATION FOR A PV + BATTERY HYBRID PLANT

NATIONAL CENTER FOR EDUCATION RESEARCH

EPITOPE AND MECHANISTIC CORRELATES OF BROADLY PROTECTIVE HUMAN ANTIBODIES FOR PNEUMOCOCCAL INFECTION - STREPTOCOCCUS PNEUMONIAE IS A LEADING INFECTIOUS PATHOGEN, CAUSING PNEUMONIA, BACTEREMIA, MENINGITIS, ACUTE OTITIS MEDIA, AND NEARLY ONE MILLION DEATHS WORLDWIDE EACH YEAR. S. PNEUMONIAE CAN BE CARRIED IN THE NASOPHARYNX ASYMPTOMATICALLY, WHICH CONTRIBUTES TO PATHOGEN SPREAD, AS PNEUMOCOCCAL CARRIAGE OFTEN PRECEDES ACTIVE INFECTION. INFECTIONS OCCUR WITH INCREASED FREQUENCY IN HIGH-RISK POPULATIONS, SUCH AS INDIVIDUALS WITH DIABETES, ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, CARDIOVASCULAR DISEASE, AND HIV. SEVERAL VACCINES ARE CURRENTLY IN USE TO PREVENT PNEUMOCOCCAL INFECTION; HOWEVER, SEVERAL FACTORS WARRANT FURTHER RESEARCH, INCLUDING LIMITED SEROTYPE COVERAGE OF CURRENT VACCINES, LIMITED VACCINE EFFICACY AGAINST SOME VACCINE- INCLUDED SEROTYPES, INCREASED INCIDENCE OF COLONIZATION AND INFECTION WITH NON-VACCINE SEROTYPES, AND WIDESPREAD DRUG AND MULTIDRUG ANTIBIOTIC RESISTANCE AMONG NON-VACCINE SEROTYPES. THIS R01 PROPOSAL WILL ADDRESS THESE LIMITATIONS BY DEFINING THE STRUCTURAL DETERMINANTS MEDIATING THE SEROTYPE BREADTH AND PROTECTIVE EFFICACY OF BROADLY-REACTIVE HUMAN MABS THAT PREVENT AND TREAT PNEUMOCOCCAL INFECTION. THE SCIENTIFIC PREMISE OF THIS PROPOSAL IS THAT MABS TO CONSERVED PNEUMOCOCCAL ANTIGENS THAT ARE BROADLY REACTIVE COULD SERVE AS PRIORITY OR ADJUNCTIVE THERAPIES FOR PNEUMOCOCCAL DISEASE MANAGEMENT. THIS PROPOSAL WILL FOCUS ON MABS TO PNEUMOCOCCAL ANTIGENS THAT ARE HIGHLY CONSERVED AND ARE TARGETS OF B CELLS DURING PNEUMOCOCCAL COLONIZATION AND INFECTION. OUR WORK WILL ADVANCE THE FIELD BY GENERATING NEW THERAPEUTIC OPTIONS FOR THE PREVENTION AND TREATMENT OF PNEUMOCOCCAL INFECTION FOR DIVERSE SEROTYPES, INCLUDING ENCAPSULATED AND NONENCAPSULATED SEROTYPES, AND BY IDENTIFYING PROTECTIVE EPITOPES ON PNEUMOCOCCAL SURFACE PROTEINS. OUR INNOVATIVE HYPOTHESIS IS THAT HUMAN MABS TARGETING CONSERVED PNEUMOCOCCAL SURFACE PROTEINS WILL EXHIBIT SUBSTANTIAL SEROTYPE BREADTH, CAN TREAT PNEUMOCOCCAL INFECTION, AND THAT MAB PROTECTIVE EFFICACY AND SEROTYPE BREADTH IS CORRELATED TO EPITOPE SPECIFICITY. OUR DATA WILL PROVIDE NEW FINDINGS FOR THE PNEUMOCOCCAL PROTEIN VACCINE FIELD. IN AIM 1, THE SEROTYPE BREADTH AND PROTECTIVE EFFICACY OF HUMAN MABS TARGETING CONSERVED PROTEIN ANTIGENS WILL BE DETERMINED IN MODELS OF BOTH PRIMARY AND SECONDARY (FOLLOWING INFLUENZA VIRUS INFECTION) PNEUMOCOCCAL INFECTION. IN AIM 2, WE WILL DEFINE THE EPITOPES MEDIATING THE PROTECTIVE EFFICACY OF THE HUMAN MABS USING X-RAY CRYSTALLOGRAPHY AND CRYO-EM, WHICH WILL BE CRITICAL TO THE FIELD BY INFORMING THE DEVELOPMENT OF PROTEIN-BASED PNEUMOCOCCAL VACCINES, AS WE HAVE SHOWN IN OUR PRELIMINARY DATA THAT THE EPITOPE ON PNEUMOCOCCAL PROTEINS IMPACTS MAB BREADTH AND PROTECTIVE EFFICACY. IN AIM 3, WE WILL CONDUCT IN DEPTH IN VITRO AND IN VIVO MECHANISTIC STUDIES TO ASSESS MAB FUNCTIONS, INCLUDING OPSONOPHAGOCYTIC AND AGGLUTINATION ACTIVITY, AND INHIBITION OF BACTERIAL GROWTH, ADHESION, INVASION, AND BIOFILM FORMATION. WE WILL ALSO ASSESS THE SPECIFIC IMMUNOLOGICAL PATHWAYS IMPORTANT FOR MAB-MEDIATED BACTERIAL CLEARANCE. OVERALL, OUR WORK IS BOTH PRACTICALLY AND CONCEPTUALLY INNOVATIVE, AND WILL CHALLENGE CURRENT TREATMENT PARADIGMS FOR PNEUMOCOCCAL INFECTION.

LIQUID HELIUM FLUID DYNAMICS STUDIES

RECOVERY ACT LIQUID HELIUM FLUID DYNAMICS STUDIES

ICPALMS A PORTAL FOR STANDARDS-BASED INSTRUCTION

INTEGRATED CLINICAL NEUROSCIENCE TRAINING FOR TRANSLATIONAL RESEARCH

MRI: TRACK 2 ACQUISITION OF PULSED 9/34 GHZ EPR SPECTROMETER FOR QUANTUM SCIENCE AND BIOCHEMICAL RESEARCH -THIS AWARD IS JOINTLY FUNDED BY THE CHEMICAL INSTRUMENTATION (CRIF) PROGRAM AND THE MAJOR RESEARCH INSTRUMENTATION (MRI) PROGRAM. PROFESSOR STEPHEN HILL FROM FLORIDA STATE UNIVERSITY AND COLLEAGUES GEOFFREY STROUSE AND WEN ZHU, TOGETHER WITH NHMFL RESEARCH FACULTY THIERRY DUBROCA AND TOMAS ORLANDO ARE ACQUIRING A STATE-OF-THE-ART PULSED ELECTRON PARAMAGNETIC RESONANCE (EPR) SPECTROMETER OPERATING AT FREQUENCIES OF 9 AND 34 GIGAHERTZ, IN MAGNETIC FIELDS UP TO 1.5 TESLA. THIS SPECTROMETER IS USED IN VARIOUS FIELDS INCLUDING CHEMISTRY, BIOLOGY, AND PHYSICS. THE SPECTROMETER ALLOWS OBSERVATION OF TRANSITIONS WHEN ELECTRONS IN A MAGNET FIELD ARE IRRADIATED WITH MICROWAVES. THE SPECTRUM OBTAINED GIVES VALUABLE INFORMATION ABOUT THE COMPOSITION OF A SAMPLE. THIS INFORMATION PROVIDES INSIGHT ON THE ENVIRONMENT NEAR THE ATOM AND THE PROPERTIES OF THE SYSTEM. AS SUCH, THE INSTRUMENTATION IS USED TO PROVIDE PRECISE STRUCTURAL DETAILS OF CHEMICALLY AND BIOLOGICALLY IMPORTANT MOLECULES ON LENGTH SCALES NOT POSSIBLE WITH NUCLEAR MAGNETIC RESONANCE, INCLUDING BOND DISTANCES AND ANGLES, AS WELL AS ACCURATE INFORMATION ABOUT THE SPATIAL ARRANGEMENTS OF MOLECULES RELATIVE TO NEIGHBORING ONES. IN ADDITION, IT IS USED TO DETERMINE THE DYNAMICAL PROPERTIES OF MAGNETIC ELECTRONS THAT ARE CENTRAL TO MODERN INFORMATION TECHNOLOGIES, INCLUDING QUANTUM SENSING AND COMPUTING. THE INSTRUMENTATION IMPACTS RESEARCH IN WIDE RANGING AREAS INCLUDING BIOCHEMISTRY, ORGANIC AND INORGANIC CHEMISTRY, CATALYSIS, MATERIALS CHEMISTRY AND PHYSICS, AS WELL AS THE GROWING AREA OF QUANTUM INFORMATION SCIENCE. THE INSTRUMENT IS AN INTEGRAL PART OF TEACHING AS WELL AS RESEARCH AND RESEARCH TRAINING OF UNDERGRADUATE AND GRADUATE STUDENTS IN CHEMISTRY, BIOCHEMISTRY AND PHYSICS AT BOTH FSU AND THE NATIONAL HIGH MAGNETIC FIELD LABORATORY (NHMFL) . THE REACH OF THE INSTRUMENTATION EXTENDS TO SIMILAR PROGRAMS AT THE NEARBY CAMPUSES OF FLORIDA AGRICULTURAL AND MECHANICAL UNIVERSITY, AN HISTORICALLY BLACK UNIVERSITY, AND THE UNIVERSITY OF FLORIDA. INTEGRATION OF THE INSTRUMENT WITH THE NHMFL USER PROGRAMS ALSO IMPACTS THE WORK OF RESEARCHERS AND STUDENTS THROUGHOUT THE US AND BEYOND, INCLUDING THE MANY PARTICIPANTS OF SCHOOLS AND WORKSHOPS ORGANIZED BY THE LAB. THE AWARD IS AIMED AT ENHANCING RESEARCH AND EDUCATION AT ALL LEVELS. RESEARCH ENABLED BY THE INSTRUMENT IS FOCUSED ON THE FOLLOWING AREAS OF STUDY: (I) OBTAINING FUNDAMENTAL UNDERSTANDING OF THE MICROSCOPIC PROCESSES THAT LIMIT THE COHERENCE OF MOLECULAR SPIN QUBITS, WITH THE AIM OF DESIGNING MOLECULES WITH BUILT-IN PROTECTION AGAINST VARIOUS SOURCES OF DECOHERENCE; (II) LINKING MOLECULAR QUBITS TO FORM ELEMENTARY QUANTUM GATES; (III) DEVELOPMENT OF ELECTRICAL AND OPTICAL SCHEMES FOR INITIALIZATION AND MANIPULATION OF SPIN QUBITS THAT ARE ESSENTIAL FOR NEXT GENERATION QUANTUM TECHNOLOGIES; (IV) SEEKING UNDERSTANDING OF THE INTRINSIC ELECTRONIC STRUCTURES AND THE ROLE OF EXTRINSIC DEFECTS IN DILUTE MAGNETIC SEMICONDUCTOR QUANTUM DOTS, WITH A VIEW TO OPTIMIZING PLASMONIC AND SPINTRONICS PROPERTIES OF IMPORTANCE TO FUTURE MICROELECTRONICS APPLICATIONS; (V) UNDERSTANDING PEPTIDE BIOSYNTHESIS FOR DESIGN OF NEXT-GENERATION ?EVOLUTION-PROOF? ANTIBIOTICS AND GREEN CATALYSTS; AND (VI) DEVELOPMENT OF NEW DYNAMIC NUCLEAR POLARIZATION AGENTS WITH PROPERTIES THAT OPTIMIZE NUCLEAR MAGNETIC RESONANCE SIGNAL ENHANCEMENTS, THEREBY GREATLY INCREASING THE SENSITIVITY OF THIS WIDELY APPLIED TECHNIQUE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

AN IMMUNODOMINANCE-BASED PAN-PNEUMOVIRUS VACCINE FOR PROTECTION AGAINST RSV AND HMPV - THE GOAL OF THIS RESEARCH PROJECT IS TO FURTHER THE DEVELOPMENT OF A PAN-PNEUMOVIRUS VACCINE AND TO TEST OUR HYPOTHESIS THAT A CHIMERIC PNEUMOVIRUS FUSION (F) PROTEIN VACCINE DISPLAYING IMMUNODOMINANT EPITOPES OF RESPIRATORY SYNCYTIAL VIRUS (RSV) AND HUMAN METAPNEUMOVIRUS (HMPV) WILL INDUCE BROAD PROTECTION AGAINST BOTH VIRUSES. RSV AND HMPV ARE WIDELY PREVALENT AGENTS OF CHILDHOOD VIRAL RESPIRATORY INFECTION, CAUSING THOUSANDS OF DEATHS AND HUNDREDS OF THOUSANDS OF HOSPITALIZATIONS EACH YEAR. THERE ARE CURRENTLY NO APPROVED VACCINES TO ELICIT PROTECTIVE ANTIBODIES AGAINST EITHER VIRUS, AND NO SPECIFIC TREATMENT OPTIONS ARE AVAILABLE. THE F GLYCOPROTEINS OF RSV AND HMPV HAVE BEEN WELL-STUDIED AS TARGETS OF NEUTRALIZING ANTIBODIES, AND SEVERAL VACCINE CANDIDATES FOR RSV ARE IN CLINICAL TRIALS. WE HAVE DEVELOPED A NOVEL VACCINE CANDIDATE (RHMS-1) ENCOMPASSING IMMUNODOMINANT EPITOPES OF BOTH RSV AND HMPV F PROTEINS AND VERIFIED ITS PROTECTIVE EFFICACY IN MOUSE AND COTTON RAT MODELS. THE RATIONALE FOR PURSUING A CHIMERIC VACCINE CANDIDATE IS BASED ON SEVERAL FACTORS, INCLUDING FOCUSING THE IMMUNE RESPONSE TO ONLY THOSE EPITOPES THAT ELICIT POTENT NEUTRALIZING ANTIBODIES RATHER THAN LESS POTENT OR NON-NEUTRALIZING EPITOPES TO IMPROVE PROTECTION, REDUCING VACCINE ESCAPE COMPARED TO PREVIOUS CHIMERIC VACCINES INCORPORATING A SINGLE EPITOPE, AND THE ASSESSMENT OF THE FIRST CHIMERIC VACCINE CANDIDATE BEYOND THE MOUSE MODEL. ADDITIONALLY, WE WILL DETERMINE IMMUNE CORRELATES OF PROTECTION FOR HMPV INFECTION IN A NONHUMAN PRIMATE MODEL. THESE CRITICAL STUDIES WILL PROVIDE A WEALTH OF IMMUNOLOGIC INFORMATION IN HIGHLY RELEVANT, PRE-CLINICAL MODELS THAT WILL GUIDE AN EVIDENCE-BASED PATH TOWARD THE OPTIMIZATION OF A SAFE AND EFFECTIVE PAN-PNEUMOVIRUS VACCINE. OUR RESEARCH WILL SUBSTANTIALLY ADVANCE THE FIELD BY DEVELOPING A VACCINE FOR PROTECTION AGAINST THE TWO LEADING CAUSES OF ACUTE LOWER RESPIRATORY TRACT INFECTION IN CHILDREN. AS THE PRE-FUSION RSV F PROTEIN HAS ALREADY DEMONSTRATED SAFETY AND THE ABILITY TO ELICIT AN EFFECTIVE IMMUNE RESPONSE, WE WILL BUILD UPON THIS SUCCESS TO EXTEND THIS VACCINE FOR PROTECTION AGAINST HMPV. IN AIM 1, WE WILL COMPUTATIONALLY STABILIZE AND REDESIGN OUR VACCINE CANDIDATE, RHMS-1, USING ROSETTA TO ENHANCE PROTEIN STABILITY AND IMMUNOGENICITY, AND THE BEST CANDIDATES WILL BE RAPIDLY SCREENED IN MICE AS BOTH PROTEIN SUBUNIT AND MRNA-LIPID NANOPARTICLE VACCINES. IN AIM 2, WE WILL CONDUCT STRUCTURAL AND EPITOPE ANALYSIS OF OUR TOP VACCINE CANDIDATE TO VERIFY THE EPITOPES ON RHMS ARE SIMILAR TO RSV F AND HMPV F PROTEINS. IN AIM 3, WE WILL DETERMINE THE PROTECTIVE EFFICACY OF THE TOP CANDIDATE RHMS VACCINE IN COTTON RAT AND AFRICAN GREEN MONKEY MODELS OF RSV AND HMPV INFECTION. OUR PROPOSAL IS BOTH CONCEPTUALLY AND PRACTICALLY INNOVATIVE AS WE ARE DESIGNING AND TESTING NOVEL VACCINE CANDIDATES FOR PROTECTION AGAINST TWO IMPORTANT RESPIRATORY PATHOGENS, AND WE ARE CHALLENGING CURRENT PARADIGMS IN THE FIELD BY PROVIDING A SINGLE ANTIGEN FOR DUAL-VIRUS PROTECTION. FURTHERMORE, THE INNOVATION OF THE TEAM IS VERY HIGH, AS THIS PROPOSAL BRINGS TOGETHER DIVERSE INVESTIGATORS AND SEVERAL STATE OF THE ART TECHNOLOGIES.

EATING DISORDERS ACROSS GENDERS, GENERATIONS, AND ADULT DEVELOPMENTAL STAGES - VERY LITTLE IS KNOWN ABOUT HOW THE PREVALENCE OF EATING DISORDERS (EDS) HAS CHANGED ACROSS GENERATIONS OR THE TRAJECTORY OF EDS OVER THE COURSE OF ADULT DEVELOPMENT. THIS STUDY OFFERS A UNIQUE OPPORTUNITY TO 1) EXAMINE ED POINT PREVALENCE AND MEAN SCORES ON DIMENSIONAL ED MEASURES ACROSS 5 COHORTS OF COLLEGE STUDENTS RANDOMLY SAMPLED FROM THE SAME UNIVERSITY POPULATION IN 1982, 1992, 2002, 2012, AND 2022, 2) EXAMINE THE LONGITUDINAL COURSE OF EATING PATHOLOGY FROM LATE ADOLESCENCE TO MIDLIFE (18 TO 62+ YEARS), AND 3) IDENTIFY PREDICTORS OF COURSE FOCUSING ON FACTORS UNIQUE TO ADULTHOOD. THIS PROJECT WILL OFFER NEW INSIGHTS INTO HOW GENERATION IMPACTS GENDER DIFFERENCES IN EDS AND HOW BOTH GENDER AND GENERATION IMPACT LONGITUDINAL TRAJECTORY. THIS PROJECT BUILDS ON A STUDY INITIATED IN 1982 AND REPLICATED WITH THE ADDITION OF NEW COHORTS AND EXTENDED WITH FOLLOW-UP OF WELL-CHARACTERIZED, ESTABLISHED COHORTS EVERY 10 YEARS SINCE ITS INCEPTION. IN THE SPRING OF 2022, 1600 UNDERGRADUATES (800 WOMEN AND 800 MEN) WILL BE RANDOMLY SAMPLED TO COMPLETE SURVEYS OF WEIGHT, HEIGHT, BODY IMAGE DISTURBANCE, DIETING, DISORDERED EATING BEHAVIORS, AND EDS. IN ADDITION, PARTICIPANTS WHO COMPLETED THESE ASSESSMENTS IN COLLEGE WILL BE SOUGHT FOR 10-, 20-, 30-, AND 40-YEAR FOLLOW- UP. WE PROJECT COLLECTING 20-YEAR FOLLOW-UP DATA IN OVER 1,700 ADULTS (>70% RETENTION), INCLUDING NEARLY 500 MEN AND OVER 400 PARTICIPANTS FROM ETHNIC/RACIAL MINORITY GROUPS. THESE DATA WILL ALLOW US TO EXAMINE GENERATION X AGE EFFECTS TO DETERMINE WHETHER COURSE OF EATING PATHOLOGY DIFFERS ACROSS BABY BOOMERS (1982 COHORT), GENERATION X (1992 COHORT), AND MILLENNIALS (2002 COHORT). THE INVESTIGATION WILL BE CONDUCTED IN TWO STAGES: A SURVEY PHASE AND AN INTERVIEW PHASE. THE SURVEY PHASE WILL REPLICATE METHODS EMPLOYED FOR DATA COLLECTION IN ALL PRIOR WAVES TO ENSURE COMPARABILITY OF DATA. SURVEYS INCLUDE DETAILED ITEMS ABOUT DEMOGRAPHIC BACKGROUND; HEIGHT AND WEIGHT; DIETING, BODY IMAGE, AND EXERCISE; 5 SCALES OF THE EATING DISORDERS INVENTORY (BULIMIA, DRIVE FOR THINNESS, MATURITY FEARS, PERFECTIONISM, AND INTERPERSONAL DISTRUST); AND SYMPTOMS OF ANOREXIA NERVOSA, BULIMIA NERVOSA, BINGE-EATING DISORDER, AND PERMIT DSM-5 ED DIAGNOSIS AND DIAGNOSES OF THEIR PARTIAL AND SUBTHRESHOLD VARIANTS. IN ADDITION, BEGINNING IN THE 3RD WAVE, SURVEYS INCLUDED THE EATING DISORDER DIAGNOSTIC SCALE WHICH IS INCLUDED AS A CORE ED ASSESSMENT FOR THE NIMH. ON THE BASIS OF SELF-REPORT SURVEY DATA, ALL SUBJECTS DIAGNOSED WITH AN ED AND CONTROLS MATCHED TO THESE SUBJECTS ON AGE, SEX, RACE, AND ETHNICITY WILL BE RECRUITED FOR PARTICIPATION IN THE INTERVIEW PHASE OF THE STUDY. INTERVIEWS WILL ESTABLISH THE VALIDITY OF SURVEY ASSESSMENTS, AS WELL AS PROVIDE DATA ON PSYCHOSOCIAL FUNCTION, SUICIDALITY, COMORBIDITY, AND TREATMENT HISTORY FOR A NONCLINICAL SAMPLE, SIMILAR TO THEIR USE IN THE 3RD WAVE, 20 YEARS AGO. THE LONG-TERM OBJECTIVES OF THIS PROJECT ARE TO EVALUATE WHETHER WE ARE MAKING PROGRESS IN REDUCING THE PUBLIC HEALTH BURDEN ASSOCIATED WITH EDS, DETERMINE THE ADULT DEVELOPMENTAL COURSE OF EDS, AND IDENTIFY PREDICTORS OF ED TRAJECTORY THAT CAN BE TRANSLATED INTO TARGETS FOR INTERVENTION, INCLUDING WHAT TO MODIFY, IN WHOM, AND WHEN.

NUCLEASE PROFILING AS AN INTEGRATIVE RESOURCE FOR MAIZE EPIGENOMICS

IMPACT OF SCHOOL-BASED BODY MASS INDEX (BMI) SCREENING ON PARENT BEHAVIOR AND CHI

BIOBEHAVIORAL PREDICTION OF ILLNESS TRAJECTORY IN BULIMIC SYNDROMES

LIQUID HELIUM FLUID DYNAMICS STUDIES

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

MODULATION OF HOST CELL EXOSOME CONTENT AND FUNCTION BY EBV LMP1

LEARNING THROUGH COLLABORATIVE DESIGN: PROFESSIONAL DEVELOPMENT TO FOSTER PRODUCTIVE EPISTEMIC DISCOURSE IN SCIENCE

CHARACTERIZING INTERSECTIONAL GEOSPATIAL STIGMA AND AFFIRMATION LANDSCAPES AND THEIR INFLUENCE ON BLACK AND LATINO BISEXUAL MEN AT RISK FOR SUBSTANCE ABUSE AND HIV - PROJECT SUMMARY GUIDED BY FUNDAMENTAL CAUSE THEORY WITH INNOVATIVE METHODOLOGIES, THIS PROPOSAL EXAMINES THE IMPACT OF GEOSPATIAL INTERSECTIONAL STIGMA AND AFFIRMATION ON SUBSTANCE USE AND HIV RISK AMONG BISEXUAL BLACK AND LATINO MEN. BISEXUAL MEN EXPERIENCE CO-MORBID HEALTH DISPARITIES INCLUDING ELEVATED SUBSTANCE USE AND HIV RISK. BLACK AND LATINO MEN ARE DISPROPORTIONATELY REPRESENTED IN BISEXUAL POPULATIONS RELATIVE TO THE GENERAL POPULATION IN THE UNITED STATES MAKING UP 45% OF BISEXUAL MEN. BISEXUAL BLACK AND LATINO MEN EXPERIENCE ELEVATED SUBSTANCE USE AND HIV RISK RELATIVE TO HETEROSEXUAL BLACK AND LATINO MEN. ONE CONTRIBUTING FACTOR IS STIGMA. INTERSECTIONALITY INFORMS US THAT BISEXUAL BLACK AND LATINO MEN EXPERIENCE A RANGE OF STIGMA TYPES INCLUDING BINEGATIVE STIGMA BASED ON THEIR SEXUAL IDENTITY, RACIST STIGMA, SUBSTANCE USE STIGMA, AND HIV STIGMA. WHILE STIGMA IS THEORIZED TO BE MULTILEVEL AND INTERSECTIONALITY EXPERIENCES HAVE CALLED FOR GEOSPATIAL EXAMINATIONS OF STIGMA, FEW STUDIES HAVE SOUGHT TO MEASURE STIGMA GEOSPATIALLY. THIS PROPOSAL SEEKS TO ADDRESS THESE LIMITATIONS BY FIRST COLLECTING A GENERAL SAMPLE OF ADULTS TO GENERATE GEOSPATIAL STIGMA SCORES THEN USING ECOLOGICAL MOMENTARY ASSESSMENT (EMA) TO QUANTIFY ACTIVITY SPACE FOR A SAMPLE OF BISEXUAL BLACK AND LATINO MEN INCLUDING MOMENTARY ASSESSMENTS OF SUBSTANCE USE AND HIV RISK. THIS WILL BE ADDRESSED THROUGH 3 SPECIFIC AIMS: AIM 1: DESCRIBE GEOSPATIAL DISTRIBUTION OF INTERSECTIONAL STIGMA IN COOK COUNTY, IL AND PALM BEACH COUNTY, FL INCLUDING BI-NEGATIVITY, RACISM, SUBSTANCE USE STIGMA AND HIV STIGMA. APPROACH. WE WILL GENERATE GEOSPATIAL STIGMA SCORES THROUGH A HOUSEHOLD-BASED PROBABILITY SAMPLE OF THE GENERAL ADULT POPULATION (N = 2,000 ). SURVEY RESPONSES WILL BE GEOCODED TO GENERATE GEOLOCATED AVERAGES OF STIGMA SCORES. HYPOTHESIS. THERE WILL BE UNEQUAL DISTRIBUTION OF STIGMA INCLUDING AREAS OF INCREASED OR DECREASED STIGMA. AIM 2: EXAMINE THE IMPACT OF GEOSPATIAL STIGMA ON THE RELATIONSHIP BETWEEN SUBSTANCE USE AND HIV RISK. APPROACH. WE WILL LINK GEOSPATIAL ESTIMATES OF STIGMA GENERATED IN AIM 1 TO A SECOND SURVEY SAMPLE OF HIV- BLACK AND LATINX BISEXUAL MEN USING EMA TO CAPTURE ACTIVITY SPACE (N = 600 ). HYPOTHESIS. BISEXUAL MEN WHO RESIDE OR HAVE ACTIVITY SPACES IN AREAS WITH HIGHER STIGMA WILL BE MORE LIKELY TO USE SUBSTANCE, AND ENGAGE IN HIV RISK BEHAVIORS, WHILE ACCESS TO AFFIRMING SOCIAL RESOURCES WILL BUFFER AGAINST GEOSPATIAL STIGMAS. AIM 3: ANALYZE QUALITATIVE PERSPECTIVES ON THE IMPACTS OF INTERSECTING STIGMAS ON SUBSTANCE USE AND HIV RISK IN BISEXUAL MEN, PROVIDER INTERACTIONS, AND MESSAGING. APPROACH. WE WILL COLLECT QUALITATIVE INTERVIEWS WITH BISEXUAL MEN (N = 48), AND KEY INFORMANTS (N = 24) ADDRESSING PERSPECTIVES ON THE IMPACT OF STIGMA ON SUBSTANCE USE AND ACCESS TO HIV PREVENTION AND COMMUNITY SERVICES AS WELL AS PREFERENCES FOR PREVENTION MESSAGING. FINDINGS WILL INFORM THE DEVELOPMENT OF MULTILEVEL INTERVENTION STRATEGIES.

NATIONAL CENTER FOR EDUCATION RESEARCH

DEVELOPING CYCLOPEPTIDE NEF INHIBITORS TO FACILITATE HIV-1 ERADICATION - PROJECT SUMMARY: WHILE CURRENTLY AVAILABLE ANTIRETROVIRALS BLOCK VIRAL REPLICATION AND THUS CONTROL HIV-1 INFECTION, THEY DO NOT CURE THE DISEASE; LATENT RESERVOIRS OF REPLICATION-COMPETENT VIRUS PERSIST. TO ERADICATE HIV-1 INFECTION, NOVEL ANTIRETRO- VIRALS MUST BE DEVELOPED. THESE DRUGS WOULD IDEALLY INDUCE THE KILLING OF INFECTED CELLS ONCE LATENCY IS REVERSED. AN ATTRACTIVE DIRECTION IN DEVELOPING SUCH ANTIRETROVIRALS IS THE INHIBITION OF THE HIV-1 NEF PROTEIN. BY MODULATING SURFACE-LEVELS OF IMMUNE RECEPTORS, NEF ENABLES INFECTED CELLS TO EVADE HOST DEFENSE MECHANISMS. AMONG THE MANY FUNCTIONS OF NEF, SURFACE DOWNREGULATIONS OF CD4 AND MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I (MHC-I) ARE THE MOST PROMINENT AND PRESUMABLY MOST RELEVANT IN ANTIRETROVIRAL DRUG DISCOVERY. BY DOWNREGULATING CD4 FROM THE CELL SURFACE, NEF ENABLES CD4-INDUCED EPITOPES OF THE VIRAL ENV PROTEIN TO REMAIN CONCEALED, WHICH RENDERS INFECTED CELLS LESS SENSITIVE TO ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY (ADCC). BY DOWNREGULATING MHC-I, NEF DISRUPTS HOST ANTIGEN PRESENTATION SO THAT INFECTED CELLS ARE PROTECTED FROM KILLING BY CYTOTOXIC T LYMPHOCYTES (CTLS). CONCEIVABLY, THERAPEUTIC INHIBITION OF THESE NEF FUNCTIONS MAY RESTORE THE ACTIVITIES OF ADCC AND CTLS, THUS FACILITATING THE DETECTION AND CLEARANCE OF INFECTED CELLS. CRYSTAL STRUCTURES SOLVED BY US SHOWED THAT NEF-MEDIATED DOWNREGULATIONS OF CD4 AND MHC-I INVOLVE A COMMON SITE ON NEF. IN EACH CASE, HOWEVER, THIS SITE IS REMODELED BY NEF’S ASSOCIATION WITH TARGET-SPECIFIC, HIJACKED CLATHRIN ADAPTOR PROTEINS (APS) TO UNIQUELY ACCOMMODATE THE INTENDED SUBSTRATE. FURTHERMORE, WHEN BOUND TO NEF, BOTH THE CD4 CYTOSOLIC TAIL AND THE MHC-I CYTOSOLIC TAIL ADOPT CURVED, NEAR-CIRCULAR POSTURES, WHICH SUGGESTS THAT THIS MULTIFUNCTIONAL SITE OF NEF CAN BE TARGETED BY CYCLIC PEPTIDES, A PROMISING NEW CLASS OF THERAPEUTICS WELL-SUITED TO DISRUPT PROTEIN- PROTEIN INTERACTIONS. SUPPORTED BY PROMISING PRELIMINARY DATA, THIS PROJECT AIMS TO DEVELOP SMALL-SIZED MACROCY- CLIC PEPTIDES CAPABLE OF MIMICKING THE CYTOSOLIC TAILS OF CD4 AND MHC-I AND THUS BLOCKING THE CELLULAR ACTIVITIES OF NEF THROUGH INHIBITION OF NEF-MEDIATED PROTEIN-PROTEIN INTERACTIONS. HIGH-AFFINITY CYCLOPEPTIDE NEF INHIBITORS WILL BE DEVELOPED THROUGH ENABLING-STRATEGIES RECENTLY ESTABLISHED IN OUR LABORATORIES. SPECIFICALLY, A POWERFUL PHAGE DISPLAY PLATFORM WILL BE APPLIED TO OPTIMIZE CD4-MIMETIC CYCLOPEPTIDE INHIBITORS THAT CAN BIND TO THE NEF/AP2 COMPLEX WITH HIGH AFFINITY. IN PARALLEL, A SIMILAR WORKFLOW WILL BE APPLIED TO DEVELOP AND OPTIMIZE MHC-I-MIMETIC CYCLOPEPTIDES INTO POTENT INHIBITORS THAT CAN BLOCK RECRUITMENT OF MHC-I INTO THE NEF/AP1 COMPLEX. HIGH-RESOLU- TION STRUCTURES OF THE CYCLOPEPTIDE-NEF COMPLEXES WILL BE OBTAINED TO ENABLE STRUCTURE-BASED OPTIMIZATION OF THE NEF INHIBITORS. USING A PANEL OF CELL-BASED ASSAYS, THESE COMPOUNDS WILL BE CHARACTERIZED FOR THEIR EFFICACY IN BLOCKING NEF FUNCTIONS IN CELLS, CELL PERMEABILITY, AND CELLULAR TOXICITY, AND THIS KNOWLEDGE WILL BE LEVERAGED TO GUIDE FURTHER DERIVATIZATION FOR IMPROVED CELLULAR ACTIVITY. SUCCESSFUL COMPLETION OF THIS WORK SHOULD YIELD CYCLIC PEPTIDE-BASED NEF INHIBITORS WITH HIGH AFFINITY IN VITRO AND SIGNIFICANT EFFICACY IN CELLS, WHICH COULD IDEALLY BE DEVELOPED INTO NOVEL ANTIRETROVIRALS WITH UNIQUE THERAPEUTIC POTENTIALS.

FOUR MTB MEMBRANE PROTEINS: STRUCTURE AND FUNCTION

AXONAL FMRP IN SYNAPTIC DEVELOPMENT - PROJECT SUMMARY THIS PROJECT WILL ADDRESS THE QUESTION OF HOW ABNORMAL SYNAPTIC DEVELOPMENT EMERGES IN NEURODEVELOPMENTAL DISORDERS. OUR OVERALL HYPOTHESIS IS THAT DISORGANIZED SYNAPTIC ADHESION AND DELAYED FUNCTIONAL ASSEMBLY OF SYNAPTIC VESICLES (SVS) IMPAIR THE FORMATION AND PHYSIOLOGICAL MATURATION OF PRESYNAPTIC TERMINALS, WHICH TRIGGERS SUBSEQUENT DEVELOPMENTAL DEFICITS IN SYNAPTIC CONNECTIVITY AND FUNCTION. WE WILL TEST THIS HYPOTHESIS IN FRAGILE X SYNDROME (FXS), A LEADING INHERITABLE FORM OF AUTISM AND INTELLECTUAL DISABILITY CAUSED BY FUNCTIONAL LOSS OF FRAGILE X MENTAL RETARDATION PROTEIN (FMRP). EXPERIMENTAL OBSERVATIONS WILL UTILIZE THE EVOLUTIONALLY CONSERVED ENDBULB TERMINALS THAT ARE READILY ACCESSIBLE FOR IN VIVO CELL-AUTONOMOUS CHARACTERIZATIONS IN CHICKEN EMBRYOS. WE WILL PURSUE TWO SPECIFIC AIMS TO TEST SEVERAL IMPORTANT HYPOTHESES DERIVED FROM OUR PRELIMINARY STUDIES. · IN SPECIFIC AIM 1, WE WILL DETERMINE THE ROLE OF FMRP-REGULATED SYNAPTIC ADHESION IN PRESYNAPTIC TERMINAL FORMATION. WE HYPOTHESIZE THAT AXONAL FMRP PROMOTES TERMINAL FORMATION, STABILIZATION, AND SELECTIVE RETRACTION THROUGH DEVELOPMENTALLY PROFILED SYNAPTIC ADHESION. TO TEST THIS HYPOTHESIS, WE WILL USE CELL-GROUP SPECIFIC AND TEMPORALLY-CONTROLLED GENETIC MANIPULATIONS COMBINED WITH IN VIVO LIVE IMAGING TO IDENTIFY THE EXACT ACTIONS OF FMRP-MEDIATED AXON TRANSPORT VS. PROTEIN TRANSLATION IN DYNAMIC TERMINAL TURNOVER. WE WILL ALSO IDENTIFY FMRP-REGULATED SYNAPTIC ADHESION ELEMENTS IN DEVELOPING TERMINALS AND ASSESS THE EFFECTS OF CORRECTING THESE ELEMENTS ON FMRP LOSS-INDUCED PRESYNAPTIC AND AXON ALTERATIONS. · IN SPECIFIC AIM 2, WE WILL DETERMINE THE ROLE OF FMRP-REGULATED SYNAPTOTAGMIN (SYT) IN FUNCTIONAL MATURATION OF PRESYNAPTIC TERMINALS. SYT1/2 ARE PRIMARY CALCIUM SENSORS ON SVS THAT TRIGGER VESICLE FUSION AND NEUROTRANSMITTER RELEASE. WE HYPOTHESIZE THAT FMRP REGULATES PRESYNAPTIC FUNCTIONAL MATURATION BY CONTROLLING THE TIMELY UPREGULATION OF SYT2 IN NASCENT TERMINALS. TO TEST THIS HYPOTHESIS, WE WILL DETERMINE THE EFFECTS OF EXPRESSING SYT2 ON FMRP LOSS-INDUCED DEFICITS IN SV ACTIVITY, PRESYNAPTIC PROTEIN MACHINERY, AND GLUTAMATE RELEASE. WE WILL ALSO DETERMINE THE INTERPLAY BETWEEN SYNAPTIC ADHESION REGULATION AND SV ASSEMBLY UNDER FMRP CONTROL USING RESCUE STUDIES. TOGETHER, THESE RESULTS WILL IDENTIFY AN ORIGIN OF DEFECTIVE SYNAPTIC PHENOTYPES, A HALLMARK OF NEURODEVELOPMENTAL DISORDERS. THIS KNOWLEDGE IS OF VITAL IMPORTANCE BECAUSE IT WILL HELP ESTABLISH A SENSITIVE TIME WINDOW AND IDENTIFY NOVEL THERAPEUTIC CANDIDATES FOR PREVENTING, OR AT LEAST REDUCING, THE PROGRESS OF SYNAPTIC DEFICITS IN FXS AND OTHER NEURODEVELOPMENTAL DISORDERS.

MATHEMATICAL LEARNING VIA ARCHITECTURAL DESIGN AND MODELING USING E-REBUILD

EXPLORING THE EFFECTS OF TEACHER RESEARCH EXPERIENCES ON CLASSROOM INQUIRY

FSU CARE APPLICATION FOR UPWARD BOUND TRIO PROGRAM AT EAST GADSDEN HIGH SCHOOL, QUINCY, FL

OCEAN MODELING AND PREDICTION

GERIATRICS WORKFORCE ENHANCEMENT PROGRAM

PURCHASE OF A FEI TITAN KRIOS FOR 3-D EM

ACQUISITION OF A GLACIOS CRYO-TEM FOR THE BIOLOGICAL SCIENCES IMAGING RESOURCE - PROJECT SUMMARY THE BIOLOGICAL SCIENCE IMAGING RESOURCE (BSIR) AT FLORIDA STATE UNIVERSITY IS THE FOCAL POINT FOR CRYOGENIC ELECTRON MICROSCOPY (CRYO-EM) IN THE STATE OF FLORIDA AND THE SOUTHEAST. NO OTHER UNIVERSITY FACILITY IN THE REGION HAS A COMPARABLE EMPHASIS OR FACILITIES. THIS APPLICATION REQUESTS FUNDS TO REPLACE AN AGEING CONVENTIONAL TRANSMISSION ELECTRON MICROSCOPE (TEM) CALLED A CM120 THAT WAS BUILT IN 1997 IS NO LONGER SUPPORTED BY SERVICE CONTRACT AND NO LONGER HAS PARTS AVAILABLE FOR REPAIR. WE WILL REPLACE THE CM120 WITH A THERMOFISHER GLACIOS CRYO-EM. THE GLACIOS WILL SERVE TWO PURPOSES: EFFICIENT SPECIMEN SCREENING AND HIGH-RESOLUTION DATA COLLECTION, ESPECIALLY FOR LOW MOLECULAR WEIGHT SAMPLES. THE GLACIOS WILL SUPPORT THE NEEDS OF 5 MAJOR USERS AND 2 MINOR USERS. THE GLACIOS IS A 200 KEV TEM WITH A FIELD EMISSION GUN (FEG). IT IS EQUIPPED WITH AN AUTOLOADER THAT CAN ROBOTICALLY LOAD UP TO 12 SAMPLES AT A TIME. THE AUTOLOADER SPECIMEN CARRIERS (CARTRIDGES) ARE COMPATIBLE WITH THE EXISTING HIGH-END TITAN KRIOS AT FSU MAKING THE GLACIOS AND IDEAL SCREENING MICROSCOPE. THE GLACIOS WILL BE EQUIPPED WITH A DIRECT ELECTRON (DE) APOLLO ELECTRON DETECTOR. THE APOLLO WILL BE THE PRIMARY DATA COLLECTION CAMERA FOR THE MICROSCOPE. WE HAVE THE FIRST COMMERCIAL APOLLO EQUIPPED ON OUR TITAN KRIOS, AND IT HAS PRODUCED THE HIGHEST RESOLUTION 3D RECONSTRUCTION AT FSU. THE APOLLO IS THE FASTEST DETECTOR ON THE MARKET WHICH MAKES IT IDEAL FOR SCREENING. THE COMBINATION OF THE FEG AND THE APOLLO MAKE THE GLACIOS A GOOD DATA COLLECTION INSTRUMENT AS WELL AS A SCREENING INSTRUMENT. THE STUDY OF FROZEN-HYDRATED SPECIMENS BY ELECTRON TOMOGRAPHY AND SINGLE PARTICLE METHODS IS A LARGE AND GROWING RESEARCH EMPHASIS WORLDWIDE. THE ROBOTIC CAPABILITIES OF THE TITAN-KRIOS WITH ITS ABILITY TO RUN STATE OF THE ART AUTOMATED EM SOFTWARE, SUCH AS LEGINON, ARE WELL ADAPTED TO THIS NEED, BUT ULTIMATELY, EFFICIENT UTILIZATION OF THE TITAN KRIOS REQUIRES PREPARATION OF QUALITY SPECIMENS THAT HAVE BEEN PRESCREENED. THE GLACIOS WILL SUPPORT NIH AND NSF FUNDED RESEARCH OF THE MAJOR USERS WHICH ENCOMPASSES THE ATOMIC RESOLUTION IMAGING OF MUSCLE FILAMENTS, WHICH HAS HEALTH RELEVENCE TO CARDIAC MUSCLE FUNCTION; RIBOSOME MODIFICATION AND CRISPR STRUCTURE & FUNCTION, THE MECHANISMS OF VESICLE TRAFFICKING SULFUR METABOLISM, AMYLOID STRUCTURAL BIOLOGY, AND AUTOMATED STRUCTURE DETERMINATION.

CONCURRENCE LEARNING CYBER-PHYSICAL FRAMEWORK FOR RESILIENT ELECTRIC POWER SYSTEM (CYBERPREPS) TO DEVELOP, VALIDATE, AND DEMONSTRATE A CONCURRENT LEARNING CYBER-PHYSICAL FRAMEWORK FOR RESILIENT ELECTRIC POWER TRANSMISSION AND DISTRIBUTION SYSTEM.

MRI: DEVELOPMENT OF A 32 TESLA ALL SUPERCONDUCTING MAGNET USING YBA2CU3O7-X COATED CONDUCTOR

TEST STAND UPGRADE FOR HIGH SPEED MACHINE TESTING

SUNSHINE STATE SOLAR GRID INITIATIVE (SUNGRIN)

U.S. GODAE: GLOBAL OCEAN PREDICTION WITH THE HYBRID COORDINATE OCEAN MODEL (HYCOM)

DEVELOPMENT OF BIOPHYSICAL APPROACHES TO INVESTIGATE HIGH-RESOLUTION STRUCTURE AND DYNAMICS OF MEMBRANE PROTEINS - ABSTRACT FUNCTIONAL RECONSTITUTION OF MEMBRANE PROTEINS HAS BEEN THE MAJOR ROADBLOCK FOR THE APPLICATION OF NMR AND OTHER BIOPHYSICAL TECHNIQUES TO INVESTIGATE THEIR HIGH-RESOLUTION DYNAMIC STRUCTURES IN A NATIVE MEMBRANE ENVIRONMENT. IN THIS APPLICATION, WE PROPOSE TO DEVELOP APPROACHES TO ENABLE HIGH-RESOLUTION STRUCTURAL STUDIES OF MEMBRANE PROTEINS AND PROTEIN-PROTEIN COMPLEXES BY A VARIETY OF BIOPHYSICAL TECHNIQUES. WE WILL DEVELOP NANODISC TECHNOLOGY FOR DETERGENT-FREE DIRECT EXTRACTION AND FUNCTIONAL RECONSTITUTION OF MEMBRANE PROTEINS FOR STRUCTURAL STUDIES OF A VARIETY OF MEMBRANE PROTEINS INCLUDING SINGLE-PASS TRANSMEMBRANE PROTEINS (SUCH AS MAMMALIAN CYTOCHROMES AND HEME OXYGENASE) AND INTEGRAL MEMBRANE PROTEINS (INCLUDING GPCRS AND GUANIDINE EXPORTER). SYNTHETIC POLYMERS DEVELOPED IN OUR LABORATORY EXHIBIT THE ABILITY TO FORM NANODISCS WITH EASILY CONTROLLABLE SIZES (FROM ~8 TO ~60 NM DIAMETER), ARE STABLE AGAINST PH AND DIVALENT METAL IONS AND CAPABLE OF DIRECTLY EXTRACTING MEMBRANE PROTEINS. OUR PRELIMINARY RESULTS DEMONSTRATE THAT THESE NANODISCS (<20 NM DIAMETER) AND MACRO-NANODISCS (>20 NM DIAMETER) REPRESENT AN EXCITING SYSTEM FOR SOLUTION AND SOLID-STATE NMR STUDIES OF MEMBRANE PROTEINS. WE ALSO PROPOSE TO USE THE NEWLY DEVELOPED NANODISC TECHNOLOGY AND NMR APPROACHES TO INVESTIGATE THE STRUCTURAL INTERACTIONS OF MAMMALIAN CYTOCHROME-P450 (P450) WITH ITS REDOX PARTNERS (P450-REDUCTASE (CPR) AND CYTOCHROME-B5 (B5)) TO BETTER UNDERSTAND HOW REDOX PARTNERS REGULATE P450 CATALYSIS AND HOW P450S METABOLIZE CHEMICALLY DIVERSE SUBSTRATES. THE STRUCTURAL ASPECTS PERTAINING TO THE CATALYTIC ACTIVITY OF P450S CONTINUE TO REMAIN ELUSIVE DUE TO A LACK OF HIGH-RESOLUTION STRUCTURES IN THEIR FULL-LENGTH, ACTIVE FORMS. PRESENTLY, STRUCTURAL STUDIES OF P450S ARE RESTRICTED TO VARIOUS TRUNCATED MAMMALIAN AND WATER-SOLUBLE BACTERIAL P450 HOMOLOGS. IN THIS STUDY, WE WILL INVESTIGATE THE STRUCTURE, DYNAMICS AND TRANSMEMBRANE DOMAIN ORIENTATION OF FULL-LENGTH MAMMALIAN P450S (2B4, 3A4 AND 3A5 ISOFORMS) ALONE AND IN COMPLEX WITH ITS REDOX PARTNER B5 AND CPR, INCORPORATED IN NANODISCS, USING A COMBINATION OF HIGH-RESOLUTION SOLUTION AND SOLID-STATE NMR TECHNIQUES. WE WILL ALSO INVESTIGATE THE TERNARY P450-B5-CPR COMPLEX IN NANODISCS IN THE PRESENCE OF SUBSTRATES TO ELUCIDATE THE MOLECULAR ORIGIN OF THE STRIKINGLY DIFFERENT EFFECTS CPR AND B5 HAVE ON P450 2B4 CATALYSIS. THE OUTCOME OF THE PROPOSED STUDIES ON P450-REDOX COMPLEXES WILL PROVIDE STRUCTURE AND DYNAMICS/FUNCTION PRINCIPLES REGULATING P450 METABOLISM OF A WIDE VARIETY OF SUBSTRATES. THE RESULTS OBTAINED FROM THIS STUDY WILL ALSO BE USEFUL TO DESIGN POTENT DRUGS TO ULTIMATELY TREAT AND PREVENT DISEASES INCLUDING CANCER.

STRUCTURAL CO-EVOLUTION OF THE LARP SUPERFAMILY AND ITS ROLE IN FUNCTIONAL PLASTICITY - PROJECT SUMMARY/ABSTRACT THE LONG-TERM GOAL OF OUR RESEARCH PROGRAM IS TO DECIPHER THE MOLECULAR MECHANISM OF “NON-CANONICAL” PROTEIN- RNA INTERACTIONS STUDYING A PARTICULARLY FASCINATING AND DISEASE-RELEVANT FAMILY OF PROTEINS, CALLED THE LA-RELATED PROTEIN (LARP) SUPERFAMILY, ON A MOLECULAR LEVEL. CYTOPLASMIC LARPS PLAY A PIVOTAL ROLE IN POST-TRANSCRIPTIONAL GENE CONTROL BY REGULATING THE DELICATE BALANCE BETWEEN ACTIVE TRANSLATION, DEGRADATION, AND STORAGE OF MRNAS. HENCE, MANY LARPS ARE INTIMATELY IMPLICATED IN VARIOUS CANCERS AND FIBROPROLIFERATIVE DISEASES RENDERING THEM AN IMPORTANT CLASS OF DRUGGABLE TARGETS. HOWEVER, THE DEVELOPMENT OF THERAPIES HAS BEEN STUNTED BY THE LACK OF DETAILED MOLECULAR-LEVEL INFORMATION. OUR RESEARCH WILL ELUCIDATE THE MOLECULAR MECHANISM OF RNA RECOGNITION EXHIBITED BY LARPS, IN PARTICULAR, TO EXPLAIN THE INTRICACIES OF COMMONALITY AND INDIVIDUALITY, I.E. HOW THEIR COM- MON RNA-BINDING MOTIF, CALLED THE LA-MODULE, HAS INDIVIDUALLY EVOLVED TO ALLOW SPECIFIC RNA RECOGNITION AND THUS ACHIEVE ITS DISTINCT FUNCTION. THE INVESTIGATION IS BASED ON OUR UNIQUE STRENGTH IN SOLUTION AND SOLID-STATE NMR SPECTROSCOPY AND THEIR CLOSE COUPLING WITH OTHER BIOCHEMICAL, BIOPHYSICAL, COMPUTATIONAL, AND FUNCTIONAL APPROACHES. OUR INITIAL EFFORTS WILL FOLLOW TWO LINES OF INQUIRY, SIMULTANEOUSLY FOCUSING ON TWO MEMBERS OF THE LARP SUPERFAMILY, HLARP6 AND HLARP1. IN THE FIRST LINE OF INQUIRY, WE WILL EXPLORE HOW THE LA-MODULE OF HLARP6 ACHIEVES THE EXCLUSIVE RECOGNITION OF THE HIGHLY CONSERVED 5' STEM-LOOP (5'SL) MOTIF, WHICH IS FOUND IN ALL VERTE- BRATE MRNAS ENCODING TYPE I COLLAGENS. THIS LINE OF STUDY WILL PROVIDE A DETAILED MOLECULAR-LEVEL MAP ON HOW INDIVIDUAL ELEMENTS OF THE LA-MODULE CONTRIBUTE TO THE SPECIFICITY AND AFFINITY OF 5'SL BINDING. THE DETAILED INSIGHTS TO BE GAINED, TOGETHER WITH CURRENTLY AVAILABLE BIOCHEMICAL AND BIOPHYSICAL DATA, WILL PROVIDE ESSENTIAL INSIGHTS INTO THE MOLECULAR “SYMBIOSIS” OF THE INDIVIDUAL ELEMENTS OF THE LA-MODULE AND CLOSE THIS CRITICAL GAP IN KNOWLEDGE REQUIRED FOR THE DEVELOPMENT OF THERAPEUTIC STRATEGIES AGAINST FIBROPROLIFERATIVE DISEASES. IN THE SECOND LINE OF INQUIRY, WE WILL ANALOGOUSLY DISSECT HOW THE LA-MODULE OF HLARP1 RECOGNIZES A DISTINCTLY DIFFERENT TYPE OF RNA COMPARED TO HLARP6. HLARP1 WAS FOUND TO BE HEAVILY INVOLVED IN PROLIFERATION AND CELL CYCLE DEFECTS AND TO BE SIGNIFICANTLY UPREGULATED IN MALIGNANT CELLS AND TISSUES. VERY RECENT BIOCHEMICAL STUDIES REVEALED THAT THE LA- MODULE OF HLARP1 SEQUENTIALLY BINDS TO THE 3' POLY(A) AND THEN TO THE 5' TERMINAL OLIGOPYRIMIDINE (5'TOP) MOTIFS OF MRNAS. NOTABLY, THIS PECULIAR TWO-STEP BEHAVIOR HAS NOT YET BEEN OBSERVED FOR ANY OTHER LARP. WE WILL UNCOVER THIS UNUSUAL MOLECULAR MECHANISM BY INVESTIGATING THE STRUCTURAL AND DYNAMIC CHANGES OF HLARP1 UPON BINDING OF THE POLY(A) AND 5'TOP MOTIFS. THIS STUDY WILL FOR THE FIRST TIME REVEAL HOW THE INITIAL BINDING OF ONE RNA TO ITS LA-MODULE ELICITS STRUCTURAL AND DYNAMIC CHANGES REQUIRED FOR THE BINDING OF A SECOND RNA TARGET. OVERALL, THESE TWO LINES OF COMPARATIVE INVESTIGATIONS WILL SYNERGISTICALLY LEAD US TO UNDERSTAND THE FUNDAMENTAL PRINCIPLES THAT CONNECT THE CO-EVOLUTION OF THE INDIVIDUAL ELEMENTS OF THE LA-MODULE AND THEIR SPECIFIC ROLE IN RNA RECOGNITION, THUS EXPLAINING HOW STRUCTURAL AND DYNAMIC PLASTICITY CONTRIBUTE TO FUNCTIONAL PLASTICITY.

REBCO COATED CONDUCTORS FOR FUSION MAGNETS

BUILDING RURAL COMMUNITY HEALTH AND RESILIENCE: THE RURAL OPIOID TECHNICAL ASSISTANCE CENTER FOR REGION 4 - THE PROJECT WILL CREATE THE SOUTHEASTERN HIGHER EDUCATION RURAL OPIOID CONSORTIUM COMPOSED OF TWENTY-FIVE UNIVERSITIES INCLUDING HISTORICALLY BLACK COLLEGES AND UNIVERSITIES (HBCUS) WHO HAVE AN EXISTING USDA COOPERATIVE EXTENSION PROGRAM AND UNIVERSITIES THAT HAVE LIBRARY SCIENCE PROGRAMS. THE 2-YEAR PROPOSED PROJECT WILL TRAIN 8,536 HBCU COOPERATIVE EXTENSION STAFF MEMBERS, HEALTH CARE PROFESSIONALS, CLINICIANS, SOCIAL WORK STUDENTS, LIBRARIANS, COMMUNITY PARTNERS, PROVIDERS, AND HIGH SCHOOL STUDENTS. THE SOUTHEASTERN HIGHER EDUCATION RURAL OPIOID CONSORTIUM WILL EXPAND AWARENESS OF OPIOID AND STIMULATE USE/MISUSE, HARM REDUCTION, AND OPTIONS FOR TREATMENT TO IMPROVE THE RESILIENCY OF RURAL COMMUNITIES IN 168 COUNTIES IN THE PROPOSED CATCHMENT WHILE FOCUSING ON CHILDREN, ADOLESCENTS, AND YOUNG ADULTS. THE TOTAL POPULATION OF THIS SELECTED CATCHMENT AREA IS 6,303,230 WITH 1.3 MILLION BEING 0-18 YEARS OF AGE, OF WHICH 51.8% ARE FEMALE AND 48.2% ARE MALE. DESPITE OVERWHELMING EVIDENCE ON THE NEED FOR MORE HELP, RURAL YOUTH ARE OVERLOOKED IN ALL FACETS OF PREVENTION AND TREATMENT. THIS PROJECT WILL USE EXISTING COOPERATIVE EXTENSION PROGRAMS AND UNIVERSITIES WITH LIBRARY SCIENCE PROGRAMS AND LOCAL LIBRARIES TO DELIVER EVIDENCE-BASED TRAINING AND RELATED MATERIALS TAILORED TO THE NEEDS OF RURAL COMMUNITIES IN THE 168 RURAL APPALACHIAN COUNTIES AND PANHANDLE OF NORTH FLORIDA PRONE TO NATURAL DISASTERS. THE ONGOING COVID-19 PANDEMIC HAS JUST ADDED TO THE ECONOMIC HARDSHIPS AND HAS NEGATIVELY IMPACTED HEALTH CONDITIONS OF AREA RESIDENTS. THE COMPLEXITY OF OPIOID USE IN RURAL COMMUNITIES CALLS FOR COMMUNITY-BASED ORGANIZING AND ENGAGEMENT STRATEGIES THAT TAP INTO THE EXPERTISE OF LOCAL, RURAL STAKEHOLDERS TO ENHANCE COMMUNITY AND INDIVIDUAL RESILIENCE TO REDUCE OPIOID USE DISORDER (OUD) AND RELATED HARMS. DESPITE THESE CHALLENGES, OPPORTUNITIES EXIST IN THIS CATCHMENT AREA TO INCREASE PREVENTION AND TREATMENT OPTIONS FOR RURAL COMMUNITIES. AS COMMUNITY HUBS AND YOUTH ACTIVITY PROVIDERS, LIBRARIES, AND EXTENSION OFFICES ARE VALUABLE STAKEHOLDERS IN PARTNERING TO ADDRESS YOUTH AND YOUNG ADULT OPIOID AND STIMULANT MISUSE. THE PUBLIC LIBRARIES WILL CONNECT COMMUNITY MEMBERS TO CREDIBLE INFORMATION AND SERVICES. RURAL LIBRARIANS WILL BE TRAINED TO IMPLEMENT THE OPIOID TOOLKIT AND DISASTER TOOLKITS AND APPROPRIATELY SCALE AND DEVELOP OUTREACH IN RESPONSE TO THE CRISIS IN THEIR COMMUNITIES. IN ADDITION TO WORKING WITH STAKEHOLDERS, HEALTH CARE PROFESSIONALS, CLINICIANS, SOCIAL WORK STUDENTS, LIBRARIANS, COMMUNITY PARTNERS, PROVIDERS, AND HIGH SCHOOL STUDENTS, WITHIN THE COMMUNITIES, THE SOUTHEASTERN HIGHER EDUCATION RURAL OPIOID CONSORTIUM WILL PROVIDE TECHNICAL ASSISTANCE TO LOCAL GOVERNMENTS TO EXPAND THE EVIDENCE-BASED KNOWLEDGE ACROSS REGION 4. THE CONSORTIUM WILL PRIORITIZE PROVIDING TECHNICAL ASSISTANCE TO RURAL CITIES AND COUNTIES IN THE CATCHMENT AREA ON STRATEGIES FOR NAVIGATING OPIOID LITIGATION SETTLEMENT FUNDS WITH THE EMPHASIS THAT LOCAL GOVERNMENT OFFICIALS AND NATIVE AMERICAN TRIBAL COUNCILS MUST ENSURE THAT THESE DOLLARS GO TOWARD ACTIONABLE STRATEGIES AND EVIDENCE-BASED SOLUTIONS THAT WILL MAKE A MEASURABLE POSITIVE IMPACT ON THE COMMUNITIES THEY SERVE. THE GOAL OF THE SOUTHEASTERN HIGHER EDUCATION RURAL OPIOID CONSORTIUM IS TO MERGE KNOWLEDGE AND PRACTICE TO PROMOTE HEALTH AND WELLBEING, INCREASE AWARENESS OF HARM REDUCTION STRATEGIES AND OPTIONS FOR TREATMENT TO IMPROVE THE RESILIENCY OF THE RURAL COMMUNITIES IN REGION 4.

SUPPORT OF EXPERIMENTAL NUCLEAR PHYSICS AT THE SUPERCOMPUTER COMPUTATIONS RESEARCH INSTITUTE

EVALUATING THE EFFICACY OF CENTRAL EXECUTIVE TRAINING (CET) FOR ADHD

NEW AUTOMATED EXPERIMENTAL AND COMPUTATIONAL PIPELINE FOR HIGH COVERAGE SINGLE-CELL HI-C AND ITS INTEGRATION WITH SINGLE CELL RNA-SEQ: ENABLING 4D NU

UNDERSTANDING FUNCTIONAL TRANSFORMATIONS CARRIED OUT BY THE BULB - PROJECT SUMMARY/ABSTRACT COMPROMISED OLFACTORY FUNCTION IS ASSOCIATED WITH THE AGING PROCESS, AS WELL AS A NUMBER OF HUMAN DISEASES. OUR INCOMPLETE UNDERSTANDING OF THE BRAIN MAKES IT CHALLENGING TO COMPREHEND THE MECHANISMS THAT UNDERLIE THESE SENSORY DEFICITS AND OTHER PSYCHIATRIC DISORDERS. UNDERSTANDING HOW SENSORY INFORMATION IS ENCODED AND TRANSFORMED BY NEURAL CIRCUITS WILL HELP DEFINE THE BASIC MECHANISMS THAT UNDERLIE THESE CHALLENGES. FOR MANY ANIMALS, SMELL IS CRITICAL FOR RECOGNIZING AND LOCATING FOOD, MATES AND DANGERS. ODOR RECOGNITION REQUIRES THE IDENTIFICATION OF A SPECIFIC SMELL THAT CAN VARY IN INTENSITY, WHILE LOCALIZATION INVOLVES DETECTING A CONCENTRATION PROFILE THAT VARIES IN TIME AND SPACE. BOTH PROCESSES MUST BE CARRIED OUT WHILE THE STIMULUS IS EMBEDDED IN A COMPLEX CHEMICAL CONTEXT. THIS REQUIRES THAT THE OLFACTORY SYSTEM RECOGNIZE AND MAINTAIN A CONCENTRATION- INVARIANT REPRESENTATION OF THE ODOR, WHILE DETECTING ITS CHANGING CONCENTRATION GRADIENT AND SEGMENTING ITS PERCEPT FROM OTHER CHEMICAL STIMULI PRESENT IN THE ENVIRONMENT. UNDERSTANDING HOW THE BRAIN CARRIES OUT THESE PROCESSES IS KEY TO UNDERSTANDING PERCEPTUAL STABILITY. THE GOAL OF THIS PROPOSAL IS TO DEFINE THE NEURAL CIRCUITS THAT SUPPORT ODOR RECOGNITION AND THE ABILITY TO ADJUST SENSITIVITY TO COMPLEX OLFACTORY SCENES IN VIVO. FIRST, WE WILL DEFINE HOW CHANGES IN ODOR CONCENTRATION ARE ENCODED AND TRANSFORMED ACROSS THE OLFACTORY BULB CIRCUIT. NEXT, WE WILL EXAMINE HOW DIFFERENT CONCENTRATIONS OR DURATIONS OF ODOR EXPOSURE IMPACT OLFACTORY BULB RESPONSES TO FUTURE ODOR STIMULATION. WE WILL THEN TEST THE HYPOTHESIS THAT OLFACTORY BULB ADAPTATION UNDERLIES DYNAMIC RANGE ADJUSTMENTS INVOLVED IN MAINTAINING SENSITIVITY IN DIFFERENT ODOR BACKGROUNDS. THIS PROPOSAL WILL ANSWER THESE QUESTIONS USING AN IMAGING APPROACH TO MEASURE THE NEURAL ACTIVITY FROM THE OLFACTORY RECEPTOR NEURON INPUT, AND THE MITRAL/TUFTED CELL OUTPUT THAT INNERVATE OLFACTORY BULB GLOMERULI. WE WILL PAIR THIS STRATEGY WITH A MECHANISTIC TOOLKIT TO DISSECT THE UNDERLYING MECHANISMS THAT DRIVE FUNCTIONAL TRANSFORMATIONS IN THE BULB. THE IMPACT OF THIS PROPOSAL WILL BE TO GENERATE A COMPREHENSIVE MECHANISTIC DESCRIPTION OF HOW TWO PERCEPTUAL FUNCTIONS ARE CARRIED OUT BY THE OLFACTORY BULB, WHICH ARE THE CRITICAL FIRST STEPS THAT WILL ULTIMATELY LINK PHYSIOLOGY WITH NATURALISTIC BEHAVIOR.

HIERARCHICAL INTERACTIONS SUPPORTING COGNITIVE CONTROL

DEVELOPMENT AND AFFERENT REGULATION OF AUDITORY NEURONS