University Of Pikeville

CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND -- INSTITUTIONAL

POWER - PURCHASE EQUIP

THIS EDA INVESTMENT FUNDS CONSTRUCTION OF THE UPIKE AG-TECH INNOVATION CENTER OF EXCELLENCE, AN AG-TECH RESEARCH AND EDUCATION CENTER TO BE LOCATED AT THE KENTUCKY ENTERPRISE INDUSTRIAL PARK (KEIP) AT MARION BRANCH IN PIKEVILLE. THE FACILITY WILL INCLUDE A GREENHOUSE, CLASSROOM SPACE, LABORATORY, AND OFFICES, TO LEAD RESEARCH EFFORTS IN HIGH-TECH AGRICULTURE THAT SUPPORTS THE CONTINUED DEVELOPMENT AND LONG-TERM VIABILITY OF THE INDUSTRY AND ITS KEY STAKEHOLDERS WHILE ALSO SUPPORTING INCREASING WORLDWIDE DEMANDS FOR FOOD PRODUCTION. ONCE COMPLETED, THE PROJECT WILL SUPPORT ENTREPRENEURIAL AND BUSINESS DEVELOPMENT STRATEGIES FOR EASTERN KENTUCKY AND CENTRAL APPALACHIA AND THE EDUCATION OF THE NEXT GENERATION OF THE AGRICULTURAL INDUSTRY WORKFORCE, WHICH WILL ASSIST A REGION HIGHLY IMPACTED BY RECENT NEGATIVE IMPACTS FROM DOWNTURNS IN THE COAL ECONOMY AND FURTHER ECONOMIC DIVERSIFICATION THROUGHOUT THE REGION.

CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND

SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

UPWARD BOUND PROGRAM IN PIKE COUNTY, KENTUCKY

UNIVERSITY OF PIKEVILLE UPWARD BOUND I

STRENGTHENING INSTITUTIONS PROGRAM (SIP)

UPWARD BOUND PROGRAM

UPWARD BOUND

HEALTH PROMOTION/DISEASE PREVENTION

SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

UPWARD BOUND PROJECT IN FLOYD AND MARTIN COUNTIES AND JENKINS INDEPENDENT IN KENTUCKY

HEALTHCARE ACCESS

UNIVERSITY OF PIKEVILLE STUDENT SUPPORT SERVICES

UNIVERSITY OF PIKEVILLE UPWARD BOUND II

EXPAND NURSING PROGRAM

STUDENT SUPPORT SERVICES PROGRAM

STUDENT SUPPORT SERVICES PROGRAM

UPWARD BOUND

UPWARD BOUND PROGRAM

TRIO - STUDENT SUPPORT SERVICES - STUDENT SUPPORT SERVICES PROGRAM

RESIDENCY TRAINING IN PRIMARY CARE

CAREER & TECHNICAL EDUCATION

CAREER & TECHNICAL EDUCATION

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM

OPIOID WORKFORCE EXPANSION PROGRAM- PROFESSIONAL

CIVIC EDUCATORS FELLOWSHIP PROGRAM

THE ANATOMICAL AND FUNCTIONAL STUDY OF THE THYMUS - DEFINING THE MILESTONES OF THE THYMIC AGING IN THE ELDERLY HUMAN POPULATION - THE CONCEPT OF THIS PROGRAM DERIVES FROM OUR OBSERVATIONS THAT THE INVOLUTION OF THE HUMAN THYMUS DOES NOT FOLLOW LINEAR KINETICS AND IS TAILORED TO EACH INDIVIDUAL. IN MOST HUMANS, THE INVOLUTION PROCESS GRADUALLY SHUTS DOWN THE THYMIC T CELL OUTPUT UNTIL ABOUT THE AGE OF FIFTY. STILL, IN SOME CASES, THE STRUCTURE AND FUNCTION OF THIS PRIMARY LYMPHATIC ORGAN ARE PRESERVED IN ELDERLY SUBJECTS UNTIL THEY ARE ABOUT 100 YEARS OLD. OUR RESEARCH PLAN ASKS HOW OFTEN WE CAN FIND A FUNCTIONAL THYMUS IN THE ELDERLY, AND WE PROPOSE A QUALITATIVE AND QUANTITATIVE STUDY OF THE THYMIC STRUCTURE USING CADAVERS IN THE GROSS ANATOMY COURSE AT KYCOM. APPLYING IMMUNOHISTOCHEMISTRY TECHNIQUES, WE WILL DETERMINE THE DEGREE OF THYMIC INVOLUTION AND RANK IT BY PRESERVING THE THYMIC EPITHELIAL SPACE, THE SYMMETRY OF THE INVOLUTION IN BOTH THYMIC LOBES, AND THE PRESENCE OF THE T CELLS. TO DETERMINE WHETHER THE THYMUS WAS FUNCTIONAL AT THE TIME OF DEATH, WE WILL APPLY MOLECULAR BIOLOGY TECHNIQUES TO AMPLIFY THE FOXN1 MRNA IN THYMIC TISSUE AND TREC (T CELL RECEPTOR REARRANGEMENT EXCISION CIRCLES) DNA IN THE SPLENOCYTES. BASED ON PRELIMINARY DATA, WE EXPECT TO FIND FOUR STAGES OF THYMIC INVOLUTION IN ELDERLY: (I) FUNCTIONAL THYMUS WITH ACTIVE THYMOPOIESIS [TEC+/CD3+/FOXN1+/TREC+], (II) FUNCTIONAL THYMUS WITH NO THYMOPOIESIS [TEC+/CD3- /FOXN1+/TREC-], (III) STRUCTURAL THYMIC SUPPORT WITH NO THYMOPOIESIS AND NO FOXN1 ACTIVITY [TEC+/CD3- /FOXN1-/TREC-], AND, (IV) SILENT, INVOLUTED THYMUS [TEC-/CD3-/FOXN1-/TREC-]. WE SHALL APPLY DESCRIPTIVE STATISTICS TO FIND THE CENTRAL TENDENCY OR A TYPICAL ELEMENT OF THE PRESERVED THYMIC FUNCTION IN OUR SAMPLE IN THE CONTEXT OF THE DONOR’S AGE AND COD. WE WILL APPLY INFERENTIAL STATISTICS TO ESTABLISH RELATIONSHIPS BETWEEN CHARACTERISTICS WITHIN THE DATA SAMPLE. IF WE DETECT THE FUNCTIONAL THYMUS, WE WILL CORRELATE IT WITH THE DEGREE OF THE STRUCTURAL PRESERVATION OF THE ORGAN AND THE CAUSE OF DEATH (COD). IN THE LONG- TERM PLAN, WE WILL APPLY THE RESULTS GENERATED FROM THIS APPLICATION TO PREDICT THE LONGEVITY OF THE IMMUNE SYSTEM BASED ON MARKERS OF THE THYMIC FUNCTION ESTABLISHED IN THIS STUDY. THIS RESEARCH PROPOSAL SERVES TWO FUNCTIONS: (1) TO MEET THE RESEARCH GOALS, AND (2) THROUGH THIS REAP FUNDING MECHANISM, TO PROVIDE THE KENTUCKY COLLEGE OF OSTEOPATHIC MEDICINE STUDENTS MUCH-NEEDED EXPOSURE TO BASIC BIOMEDICAL RESEARCH. TO ENSURE THE FEASIBILITY OF THE PROPOSED WORK, WE FORMED AN INTERDISCIPLINARY TEAM OF EXPERTS IN IMMUNOLOGY, MOLECULAR BIOLOGY, GROSS ANATOMY, AND STATISTICS. OVER THREE YEARS, WE WILL OFFER SIXTEEN RESEARCH FELLOWSHIPS TO OSTEOPATHIC MEDICAL STUDENTS TO PROVIDE MUCH-NEEDED EXPOSURE TO BASIC BIOMEDICAL RESEARCH.

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND-STRENGTHENING INSTITUTIONS PROGRAM

UNIVERSITY OF PIKEVILLE ACE - TRIO STUDENT SUPPORT SERVICES PROGRAM

CAREER PATHWAYS AT UPIKE

RESEARCH & EVALUATION

RESEARCH

HEALTH IN THE MOUNTAINS: BOOSTING THE MEDICAL HUMANITIES AS AN EDUCATION OF IMPACT IN EASTERN KENTUCKY [A SPOTLIGHT ON HUMANITIES IN HIGHER EDUCATION GRANT WILL SUPPORT THE ENHANCEMENT OF A MEDICAL HUMANITIES MAJOR AT THE UNIVERSITY OF PIKEVILLE (UPIKE). OUR PROPOSED PROJECT IS THE FINAL PHASE OF AN ONGOING RESTRUCTURE OF THE UNIVERSITY?S DIVISION OF HUMANITIES AND IS A NATURAL PROGRESSION OF UPIKE?S FOCUS ON THE HEALTH PROFESSIONS, OUR MISSION TO ADDRESS HEALTH NEEDS IN EASTERN KENTUCKY, AND OUR GOAL TO PRODUCE LIBERALLY-EDUCATED STUDENTS WHO ARE PREPARED TO MAKE AN IMPACT ON THE REGION.]

HEALTH EDUCATION

ENTREPRENEURSHIP

PLANNING AN INDUSTRY-LED HIGH-TECH GREENHOUSE CREDENTIALING PROGRAM FOR NON-TRADITIONAL & DISADVANTAGED STUDENTS

DISTANCE LEARNING GRANT

THIS EDA AMENDED INVESTMENT FUNDS CONSTRUCTION OF THE UPIKE AG-TECH INNOVATION CENTER OF EXCELLENCE, AN AG-TECH RESEARCH AND EDUCATION CENTER TO BE LOCATED AT THE KENTUCKY ENTERPRISE INDUSTRIAL PARK (KEIP) AT MARION BRANCH IN PIKEVILLE. THE FACILITY WILL INCLUDE A GREENHOUSE, CLASSROOM SPACE, LABORATORY, AND OFFICES, TO LEAD RESEARCH EFFORTS IN HIGH-TECH AGRICULTURE THAT SUPPORTS THE CONTINUED DEVELOPMENT AND LONG-TERM VIABILITY OF THE INDUSTRY AND ITS KEY STAKEHOLDERS WHILE ALSO SUPPORTING INCREASING WORLDWIDE DEMANDS FOR FOOD PRODUCTION. ONCE COMPLETED, THE PROJECT WILL SUPPORT ENTREPRENEURIAL AND BUSINESS DEVELOPMENT STRATEGIES FOR EASTERN KENTUCKY AND CENTRAL APPALACHIA AND THE EDUCATION OF THE NEXT GENERATION OF THE AGRICULTURAL INDUSTRY WORKFORCE, WHICH WILL ASSIST A REGION HIGHLY IMPACTED BY RECENT NEGATIVE IMPACTS FROM DOWNTURNS IN THE COAL ECONOMY AND FURTHER ECONOMIC DIVERSIFICATION THROUGHOUT THE REGION.