Loading organization details...
Loading organization details...
Source: IRS Form 990 via ProPublica Nonprofit Explorer
Total Revenue
▼$3M
Total Contributions
$423.8K
Total Expenses
▼$2.2M
Total Assets
$5.5M
Total Liabilities
▼$5.2M
Net Assets
$262K
Officer Compensation
→$0
Other Salaries
$818K
Investment Income
▼$0
Fundraising
▼$0
Source: USAspending.gov · Searched by organization name
Total Federal Funding
$4M
Awards Found
3
| Awarding Agency | Description | Amount | Fiscal Year | Period |
|---|---|---|---|---|
| Department of Health and Human Services | DEVELOPMENT OF SMALL MOLECULE THERAPEUTICS FOR MITIGATING OPIOID WITHDRAWAL SYNDROME - PROJECT SUMMARY THE USE OF OPIOIDS FOR MANAGING PAIN IS WIDESPREAD, BUT IT IS PLAGUED BY SEVERAL LIMITATIONS, INCLUDING THE DEVELOPMENT OF DEPENDENCE, DECREASING EFFICACY OVER TIME, AND ADVERSE SOMATIC EFFECTS. OPIOID USE DISORDER (OUD) IS A GROWING GLOBAL HEALTH PROBLEM WITH A MARKET SIZE OF $4.81 BILLION BY 2028. THE CURRENT STANDARD OF CARE INVOLVES USING OPIOID REPLACEMENT THERAPIES SUCH AS METHADONE AND BUPRENORPHINE, HOWEVER, THESE TREATMENTS ARE ASSOCIATED WITH HIGH RATES OF RELAPSE AND PROBLEMATIC SIDE EFFECTS. ALL OPIOID DRUGS TARGET THE Μ-OPIOID RECEPTOR (MOR) TO PRODUCE BOTH POSITIVE THERAPEUTIC RESULTS AND NEGATIVE SIDE EFFECTS. RESEARCH CONDUCTED ON THE MOR HAS DEMONSTRATED THE POSSIBILITY OF SEGREGATING ITS DOWNSTREAM SIGNALING PATHWAYS TO PRESERVE PAIN RELIEF WHILE REDUCING THE RISKS OF DEPENDENCE. HOWEVER, ACHIEVING THAT GOAL SOLELY BY TARGETING MOR IS CHALLENGING. EVODENOVO FOUNDERS UNCOVERED A G PROTEIN-COUPLED RECEPTOR GPR139 WITH “ANTI-OPIOID” ACTIVITY, WHICH SELECTIVELY SEPARATES THE BEHAVIORAL EFFECTS OF OPIOIDS. THIS DISCOVERY HAS THE POTENTIAL TO ENHANCE OPIOID PAIN RELIEF WHILE REDUCING DEPENDENCE, MAKING IT A PROMISING TREATMENT FOR OUD. THE PROJECT AIMS TO DEVELOP SMALL MOLECULE COMPOUNDS TO TREAT OUD BY TARGETING GPR139. EVODENOVO ASSEMBLED A MULTI-DISCIPLINARY TEAM OF WIDE RANGING EXPERTISE IN GENETIC NEURONAL MODELS, GPCR SIGNALING, MEDICINAL CHEMISTRY AND OPIOID PHARMACOLOGY TO PURSUE THE FOLLOWING AIMS: 1) DEVELOP DRUG-LIKE SMALL MOLECULE INHIBITORS OF GPR139, 2) OPTIMIZE LEAD COMPOUNDS FOR MODULATION OF OPIOID EFFECTS IN ENDOGENOUS NEURONAL SYSTEMS, AND 3) PERFORM TESTING OF GPR139 LEAD COMPOUNDS FOR OPIOID EFFECTS IN RODENTS. THE OVERALL GOAL OF THIS PROJECT IS TO IDENTIFY THE MOST PROMISING COMPOUNDS THAT CAN EFFECTIVELY REDUCE OPIOID DEPENDENCE IN MOUSE MODELS. THE FOLLOWING STEPS WILL INVOLVE OBTAINING IND DESIGNATION, MANUFACTURING, CONDUCTING CLINICAL TRIALS, AND ULTIMATELY GAINING APPROVAL FROM THE FDA. THIS WILL ENABLE THE COMMERCIALIZATION OF A PIONEERING THERAPEUTIC SOLUTION FOR THE TREATMENT OF OPIOID USE DISORDER (OUD). EVODENOVO RFA-DA-23-021/ PI: SID A. LABED PROJECT SUMMARY - PAGE 1 OF 1 | $2M | FY2022 | Apr 2022 – Aug 2027 |
| Department of Health and Human Services | A NOVEL, NON-CYTOTOXIC, EPIGENETIC THERAPEUTIC FOR SICKLE CELL DISEASE | $1.7M | FY2017 | Apr 2017 – Jul 2020 |
| Department of Health and Human Services | IDENTIFICATION OF CYCLIC PEPTIDE ANTAGONISTS OF AN ANTI-OPIOID G PROTEIN-COUPLED RECEPTOR - IDENTIFICATION OF CYCLIC PEPTIDE ANTAGONISTS OF AN ANTI-OPIOID G PROTEIN-COUPLED RECEPTOR RFA-DA-19-019 R43 PHASE I SBIR PI: SID A. LABED PROJECT SUMMARY THE HIGHLY ADDICTIVE PROPERTIES OF OPIOID DRUGS, COUPLED WITH ROUTINE OVER-PRESCRIPTION, HAVE RESULTED IN A NATIONAL CRISIS. ACCIDENTAL OVERDOSE BY OPIOIDS HAS INCREASED OVER 400% IN THE LAST 15 YEARS, FROM ~8,000 OPIOID- RELATED OVERDOSES TO MORE THAN 30,000 IN 2015. THE STAGGERING COST OF THE OPIOID HEALTH CRISIS TO THE AMERICAN PUBLIC EXCEEDS $50 BILLION ANNUALLY, HIGHLIGHTING THE NEED FOR SAFER THERAPEUTICS FOR PAIN MANAGEMENT. DRS. KIRILL MARTEMYANOV AND BROCK GRILL AT THE SCRIPPS INSTITUTE, FLORIDA, HAVE ENGINEERED A MODEL SYSTEM EXPRESSING A FUNCTIONAL MAMMALIAN OPIOID RECEPTOR (MOR) IN THE MODEL NEMATODE CAENORHABDITIS ELEGANS FOR DISCOVERY OF OPIOID MODULATORS. USING THIS SYSTEM, THEY IDENTIFIED AN ORPHAN G PROTEIN COUPLED RECEPTOR, GPR139, AS A NEGATIVE REGULATOR OF MOR SIGNALING. IN MAMMALS, GPR139 IS CO-EXPRESSED WITH MOR IN OPIOID-SENSITIVE BRAIN REGIONS AND INFLUENCES MOR TRAFFICKING AND SIGNALING. DELETION OF GPR139 IN MICE ENHANCED OPIOID-INDUCED INHIBITION OF NEURONAL FIRING, INCREASED THE ANALGESIC AND REWARDING EFFECTS OF MORPHINE, AND REDUCED WITHDRAWAL. PREVIOUS EFFORTS TO TARGET GPR139, WHICH HAVE LARGELY FOCUSED ON IDENTIFICATION OF SMALL MOLECULE AGONISTS, HAS FAILED TO PRODUCE A THERAPEUTIC CANDIDATE ANTAGONIST WITH FAVORABLE PHARMACOLOGICAL PROPERTIES. TO ADDRESS THIS UNMET NEED, EVODENOVO WILL SCREEN AN INNOVATIVE LIBRARY OF CYCLIC PEPTIDES (CPS) FOR NEW GPR139 ANTAGONISTS BY COMBINING TWO STATE-OF-THE-ART C. ELEGANS TECHNOLOGIES EXCLUSIVE TO EVODENOVO: 1) INVIVO DISPLAY: A HIGH-THROUGHPUT SCREENING TECHNOLOGY INVENTED BY EVODENOVO THAT CAN BE USED FOR PEPTIDE-BASED DRUG DISCOVERY THAT BYPASSES THE NECESSITY OF PEPTIDE PURIFICATION BY DIRECTLY FEEDING LIVE RECOMBINANT E. COLI CLONES, EACH EXPRESSING A DIFFERENT CYCLIC PEPTIDE, DIRECTLY TO NEMATODES EXPRESSING MAMMALIAN MOR AND HUMAN GP139. THIS DRASTICALLY REDUCES THE COST AND TIME FOR SCREENING. 2) THE ANTI-OPIOID BEHAVIOR PLATFORM DEVELOPED AT SCRIPPS BY DRS. MARTEMYANOV AND GRIL THAT ASSESSES THE BEHAVIORAL EFFECTS OF OPIOIDS AND IDENTIFIES PHARMACOLOGICAL OUTCOMES OF DIFFERENT DRUGS. THE COMBINATION OF BOTH PLATFORMS, ASSISTED BY AN AUTOMATED C. ELEGANS MOVEMENT TRACKING SYSTEM, WILL YIELD A POWERFUL HIGH THROUGHPUT SCREENING ENGINE CAPABLE OF INTERROGATING THOUSANDS OF RECOMBINANT PEPTIDES WITHIN A FEW DAYS, ALL IN A UNIQUE IN VIVO SETUP. GPR139 ANTAGONISTS IDENTIFIED USING THIS ASSAY WOULD LIKELY BE MISSED BY CONVENTIONAL SCREENING PROTOCOLS. EVODENOVO USES CPS INSTEAD OF LINEAR PEPTIDES. THE CYCLIZATION OF PEPTIDES INCREASES GUT STABILITY BY ELIMINATING VULNERABLE N- AND C-TERMINI, REDUCES SUSCEPTIBILITY TO PROTEOLYTIC HYDROLYSIS, AND ENHANCES MEMBRANE PERMEABILITY. THERE ARE 2 SPECIFIC AIMS: AIM 1: PERFORM A BEHAVIORAL SCREEN FOR CYCLIC PEPTIDE ANTAGONISTS OF GPR139 IN C. ELEGANS. AIM 2: VALIDATE HITS GENERATED FROM THE C. ELEGANS PLATFORM IN MAMMALIAN CELL-BASED ASSAYS. THIS PHASE I PROPOSAL WILL PROVIDE THE FOUNDATION FOR A PHASE II SBIR WHICH WILL INCLUDE A LARGER-SCALE SCREEN AND FOLLOW-UP ON PRIORITIZING CP HITS, MAMMALIAN TESTING, AND IND ENABLING STUDIES. EVODENOVO RFA-DA-19-019/ PI: SID A. LABED PROJECT SUMMARY - PAGE 1 OF 1 | $255.1K | FY2022 | Apr 2022 – Oct 2023 |
Department of Health and Human Services
$2M
DEVELOPMENT OF SMALL MOLECULE THERAPEUTICS FOR MITIGATING OPIOID WITHDRAWAL SYNDROME - PROJECT SUMMARY THE USE OF OPIOIDS FOR MANAGING PAIN IS WIDESPREAD, BUT IT IS PLAGUED BY SEVERAL LIMITATIONS, INCLUDING THE DEVELOPMENT OF DEPENDENCE, DECREASING EFFICACY OVER TIME, AND ADVERSE SOMATIC EFFECTS. OPIOID USE DISORDER (OUD) IS A GROWING GLOBAL HEALTH PROBLEM WITH A MARKET SIZE OF $4.81 BILLION BY 2028. THE CURRENT STANDARD OF CARE INVOLVES USING OPIOID REPLACEMENT THERAPIES SUCH AS METHADONE AND BUPRENORPHINE, HOWEVER, THESE TREATMENTS ARE ASSOCIATED WITH HIGH RATES OF RELAPSE AND PROBLEMATIC SIDE EFFECTS. ALL OPIOID DRUGS TARGET THE Μ-OPIOID RECEPTOR (MOR) TO PRODUCE BOTH POSITIVE THERAPEUTIC RESULTS AND NEGATIVE SIDE EFFECTS. RESEARCH CONDUCTED ON THE MOR HAS DEMONSTRATED THE POSSIBILITY OF SEGREGATING ITS DOWNSTREAM SIGNALING PATHWAYS TO PRESERVE PAIN RELIEF WHILE REDUCING THE RISKS OF DEPENDENCE. HOWEVER, ACHIEVING THAT GOAL SOLELY BY TARGETING MOR IS CHALLENGING. EVODENOVO FOUNDERS UNCOVERED A G PROTEIN-COUPLED RECEPTOR GPR139 WITH “ANTI-OPIOID” ACTIVITY, WHICH SELECTIVELY SEPARATES THE BEHAVIORAL EFFECTS OF OPIOIDS. THIS DISCOVERY HAS THE POTENTIAL TO ENHANCE OPIOID PAIN RELIEF WHILE REDUCING DEPENDENCE, MAKING IT A PROMISING TREATMENT FOR OUD. THE PROJECT AIMS TO DEVELOP SMALL MOLECULE COMPOUNDS TO TREAT OUD BY TARGETING GPR139. EVODENOVO ASSEMBLED A MULTI-DISCIPLINARY TEAM OF WIDE RANGING EXPERTISE IN GENETIC NEURONAL MODELS, GPCR SIGNALING, MEDICINAL CHEMISTRY AND OPIOID PHARMACOLOGY TO PURSUE THE FOLLOWING AIMS: 1) DEVELOP DRUG-LIKE SMALL MOLECULE INHIBITORS OF GPR139, 2) OPTIMIZE LEAD COMPOUNDS FOR MODULATION OF OPIOID EFFECTS IN ENDOGENOUS NEURONAL SYSTEMS, AND 3) PERFORM TESTING OF GPR139 LEAD COMPOUNDS FOR OPIOID EFFECTS IN RODENTS. THE OVERALL GOAL OF THIS PROJECT IS TO IDENTIFY THE MOST PROMISING COMPOUNDS THAT CAN EFFECTIVELY REDUCE OPIOID DEPENDENCE IN MOUSE MODELS. THE FOLLOWING STEPS WILL INVOLVE OBTAINING IND DESIGNATION, MANUFACTURING, CONDUCTING CLINICAL TRIALS, AND ULTIMATELY GAINING APPROVAL FROM THE FDA. THIS WILL ENABLE THE COMMERCIALIZATION OF A PIONEERING THERAPEUTIC SOLUTION FOR THE TREATMENT OF OPIOID USE DISORDER (OUD). EVODENOVO RFA-DA-23-021/ PI: SID A. LABED PROJECT SUMMARY - PAGE 1 OF 1
Department of Health and Human Services
$1.7M
A NOVEL, NON-CYTOTOXIC, EPIGENETIC THERAPEUTIC FOR SICKLE CELL DISEASE
Department of Health and Human Services
$255.1K
IDENTIFICATION OF CYCLIC PEPTIDE ANTAGONISTS OF AN ANTI-OPIOID G PROTEIN-COUPLED RECEPTOR - IDENTIFICATION OF CYCLIC PEPTIDE ANTAGONISTS OF AN ANTI-OPIOID G PROTEIN-COUPLED RECEPTOR RFA-DA-19-019 R43 PHASE I SBIR PI: SID A. LABED PROJECT SUMMARY THE HIGHLY ADDICTIVE PROPERTIES OF OPIOID DRUGS, COUPLED WITH ROUTINE OVER-PRESCRIPTION, HAVE RESULTED IN A NATIONAL CRISIS. ACCIDENTAL OVERDOSE BY OPIOIDS HAS INCREASED OVER 400% IN THE LAST 15 YEARS, FROM ~8,000 OPIOID- RELATED OVERDOSES TO MORE THAN 30,000 IN 2015. THE STAGGERING COST OF THE OPIOID HEALTH CRISIS TO THE AMERICAN PUBLIC EXCEEDS $50 BILLION ANNUALLY, HIGHLIGHTING THE NEED FOR SAFER THERAPEUTICS FOR PAIN MANAGEMENT. DRS. KIRILL MARTEMYANOV AND BROCK GRILL AT THE SCRIPPS INSTITUTE, FLORIDA, HAVE ENGINEERED A MODEL SYSTEM EXPRESSING A FUNCTIONAL MAMMALIAN OPIOID RECEPTOR (MOR) IN THE MODEL NEMATODE CAENORHABDITIS ELEGANS FOR DISCOVERY OF OPIOID MODULATORS. USING THIS SYSTEM, THEY IDENTIFIED AN ORPHAN G PROTEIN COUPLED RECEPTOR, GPR139, AS A NEGATIVE REGULATOR OF MOR SIGNALING. IN MAMMALS, GPR139 IS CO-EXPRESSED WITH MOR IN OPIOID-SENSITIVE BRAIN REGIONS AND INFLUENCES MOR TRAFFICKING AND SIGNALING. DELETION OF GPR139 IN MICE ENHANCED OPIOID-INDUCED INHIBITION OF NEURONAL FIRING, INCREASED THE ANALGESIC AND REWARDING EFFECTS OF MORPHINE, AND REDUCED WITHDRAWAL. PREVIOUS EFFORTS TO TARGET GPR139, WHICH HAVE LARGELY FOCUSED ON IDENTIFICATION OF SMALL MOLECULE AGONISTS, HAS FAILED TO PRODUCE A THERAPEUTIC CANDIDATE ANTAGONIST WITH FAVORABLE PHARMACOLOGICAL PROPERTIES. TO ADDRESS THIS UNMET NEED, EVODENOVO WILL SCREEN AN INNOVATIVE LIBRARY OF CYCLIC PEPTIDES (CPS) FOR NEW GPR139 ANTAGONISTS BY COMBINING TWO STATE-OF-THE-ART C. ELEGANS TECHNOLOGIES EXCLUSIVE TO EVODENOVO: 1) INVIVO DISPLAY: A HIGH-THROUGHPUT SCREENING TECHNOLOGY INVENTED BY EVODENOVO THAT CAN BE USED FOR PEPTIDE-BASED DRUG DISCOVERY THAT BYPASSES THE NECESSITY OF PEPTIDE PURIFICATION BY DIRECTLY FEEDING LIVE RECOMBINANT E. COLI CLONES, EACH EXPRESSING A DIFFERENT CYCLIC PEPTIDE, DIRECTLY TO NEMATODES EXPRESSING MAMMALIAN MOR AND HUMAN GP139. THIS DRASTICALLY REDUCES THE COST AND TIME FOR SCREENING. 2) THE ANTI-OPIOID BEHAVIOR PLATFORM DEVELOPED AT SCRIPPS BY DRS. MARTEMYANOV AND GRIL THAT ASSESSES THE BEHAVIORAL EFFECTS OF OPIOIDS AND IDENTIFIES PHARMACOLOGICAL OUTCOMES OF DIFFERENT DRUGS. THE COMBINATION OF BOTH PLATFORMS, ASSISTED BY AN AUTOMATED C. ELEGANS MOVEMENT TRACKING SYSTEM, WILL YIELD A POWERFUL HIGH THROUGHPUT SCREENING ENGINE CAPABLE OF INTERROGATING THOUSANDS OF RECOMBINANT PEPTIDES WITHIN A FEW DAYS, ALL IN A UNIQUE IN VIVO SETUP. GPR139 ANTAGONISTS IDENTIFIED USING THIS ASSAY WOULD LIKELY BE MISSED BY CONVENTIONAL SCREENING PROTOCOLS. EVODENOVO USES CPS INSTEAD OF LINEAR PEPTIDES. THE CYCLIZATION OF PEPTIDES INCREASES GUT STABILITY BY ELIMINATING VULNERABLE N- AND C-TERMINI, REDUCES SUSCEPTIBILITY TO PROTEOLYTIC HYDROLYSIS, AND ENHANCES MEMBRANE PERMEABILITY. THERE ARE 2 SPECIFIC AIMS: AIM 1: PERFORM A BEHAVIORAL SCREEN FOR CYCLIC PEPTIDE ANTAGONISTS OF GPR139 IN C. ELEGANS. AIM 2: VALIDATE HITS GENERATED FROM THE C. ELEGANS PLATFORM IN MAMMALIAN CELL-BASED ASSAYS. THIS PHASE I PROPOSAL WILL PROVIDE THE FOUNDATION FOR A PHASE II SBIR WHICH WILL INCLUDE A LARGER-SCALE SCREEN AND FOLLOW-UP ON PRIORITIZING CP HITS, MAMMALIAN TESTING, AND IND ENABLING STUDIES. EVODENOVO RFA-DA-19-019/ PI: SID A. LABED PROJECT SUMMARY - PAGE 1 OF 1
Source: Federal Audit Clearinghouse (fac.gov)
No federal single audit records found for this organization.
Single audits are required for entities expending $750,000+ in federal awards annually.
Source: IRS e-Filed Form 990
No officer or director compensation data available for this organization.
This data is sourced from IRS Form 990, Part VII. It may not be available if the organization files Form 990-N (e-Postcard) or has not yet been enriched.
Source: IRS Publication 78, Auto-Revocation List & e-Postcard Data
Tax-deductible contributions: Yes
Deductibility code: PC
WarningTax-exempt status was revoked on November 15, 2016
Reinstated on November 15, 2016
Exemption type: 00
Sources: IRS e-Filed Form 990 (XML) & ProPublica Nonprofit Explorer
Scroll →
| Year | Revenue | Contributions | Expenses | Assets | Net Assets |
|---|---|---|---|---|---|
| 2023 | $3M | $423.8K | $2.2M | $5.5M | $262K |
| 2022 | $2.2M | $188.5K | $2.1M | $5.6M | -$603.3K |
| 2021 | $2.1M | $143.9K | $2.2M | $236.9K | -$639.8K |
| 2020 | $2M | $123K | $2.1M | $284K |
Sources: ProPublica Nonprofit Explorer & IRS e-File Index
| Tax Year | Form Type | Source | Documents |
|---|---|---|---|
| 2024 | 990 | IRS e-File | PDF not yet published by IRSView Filing → |
| 2023 | 990 | DataIRS e-File | PDF not yet published by IRSView Filing → |
| 2022 | 990 | DataIRS e-File |
Financial data: IRS Form 990 via ProPublica Nonprofit Explorer (Tax Year 2023)
Federal grants: USAspending.gov (live)
Organization info: IRS Business Master File · ProPublica Nonprofit Explorer
Tax-deductibility: IRS Publication 78
Revocation status: IRS Auto-Revocation List
| -$811.9K |
| 2019 | $1.9M | $119.7K | $1.9M | $204.5K | -$707.6K |
| 2018 | $1.6M | $154.6K | $1.6M | $169.2K | -$739K |
| 2017 | $1.8M | $869.1K | $1.8M | $145.6K | -$743.8K |
| 2016 | $1.2M | $710.9K | $1.7M | $236.6K | -$676.6K |
| 2021 | 990 | Data |
| 2020 | 990 | Data |
| 2019 | 990 | Data |
| 2018 | 990 | Data |
| 2017 | 990 | Data | PDF not yet published by IRS |
| 2016 | 990 | Data |