Love Inc

HEAD START AND EARLY HEAD START

SPECIAL PROGRAMS (SP)

SPECIAL PROGRAMS (SP)

HEAD START AND EARLY HEAD START - 2017 CONTINUATION

SPECIAL PROGRAMS (SP)

SPECIAL PROGRAMS (SP)

SPECIAL PROGRAMS (SP)

SPECIAL PROGRAMS (SP)

HEALTH CENTER CLUSTER

PRODUCTION OF THE HARVEST LENTIL PRO COMMODITY UNDER THE INTERNATIONAL FOOD RELIEF PARTNERSHIP (IFRP) PROGRAM

RESEARCH AND DEVELOPMENT OF BETTER DIAGNOSIC TOOLS FOR MENTAL ILLNESS, NEUROLOGICAL DISORDERS, TRAUMATIC BRAIN INJURY AND POST TRAUMATIC STRESS DISOR

FOOD FOR PEACE EMERGENCY PROGRAM (EP)

BREEDLOVE IFRP

HEALTH CENTER CLUSTER

THIS IS A DUMMY RECORD TO ALLOW FOR OTHER ENTRY.

UNKNOWN TITLE

PURPOSE: EXTEND/EXPAND RUNWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT EXPANDS RUNWAY 15/33 AN ADDITIONAL 50 FEET IN WIDTH TO BRING THE AIRPORT INTO CONFORMITY WITH CURRENT STANDARDS. THIS GRANT FUNDS A PORTION OF PHASE 2, WHICH CONSISTS OF CONSTRUCTION. THIS GRANT IS ASSOCIATED WITH AN AIRPORT INFRASTRUCTURE GRANT THAT FUNDS THE REMAINING ELIGIBLE PORTION OF THE PHASE. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH LOVELAND, COLORADO.

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

UNKNOWN TITLE

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPACT AID PROGRAM TITLE VIII SECTION 8003 AND SECTION 8007(A)

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPACT AID PROGRAM TITLE VIII SECTION 8003

IMPACT AID PROGRAM TITLE VIII SECTION 8003

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

HEAD START AND EARLY HEAD START

IMPACT AID PROGRAM TITLE VIII SECTION 8003

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

INCREMENTALLY FUND THE GRANT

EARLY HEAD START/CHILD CARE PARTNERSHIP & 2016 COLA

DEMINING AND MINE VICTIM ASSISTANCE

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN-LICENSED AND TEXAS-EXEMPT AND FLORIDA-DELICENSED ONLY

MRN: MISSION OF DISCOVERY AND ADVANCEMENT OF CLINICAL SOLUTIONS FOR THE PREVENTION, DIAGNOSIS, AND TREATMENT OF MENTAL ILLNESS AND OTHER BRAIN DISOR

IDENTIFICATION OF THERAPEUTICS FOR THE TREATMENT OF SULFUR MUSTARD INJURY (U54)

CLOVER PARK TECHNICAL COLLEGE APPLICATION FOR HEERF INSTITUTIONAL PORTION ALLOCATION

IMPACT AID PROGRAM TITLE VIII SECTION 8003

IMPROVE EXISTING AIRPORT

EARLY HEAD START/CHILD CARE PARTNERSHIP

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

BIOLOGICAL BASES FOR RADIATION ADAPTIVE RESPONSES IN THE LUNG

NEURAL MECHANISM OF SCHIZOPHRENIA: USE OF MULTIPLE NEUROIMAGING TOOLS TO EXAMINE

MINE ACTION ACTIVITIES IN BOSNIA AND HERZEGOVINA

NEW AWARD OBLIGATING $2,500,000 IN FY21/22 NADR-CWD KAZAKHSTAN BILATERAL FUNDS. POP 24 MONTHS. SEE TERMS AND CONDITIONS BELOW.

CWD

CLOVER PARK TECHNICAL COLLEGE APPLICATION FOR EMERGENCY FINANCIAL GRANTS ALLOCATION

RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN- PRELICENSED - A GREATER LOVE FOSTER FAMILY AGENCY, INC. IS A FEDERALLY FUNDED RESIDENTIAL TFC PROGRAM WITHIN THE OFFICE OF REFUGEE RESETTLEMENT (ORR) THAT PROVIDES TEMPORARY CARE AND SERVICES FOR UNACCOMPANIED ALIEN CHILDREN ARRIVING IN THE UNITED STATES WITHOUT PARENTS OR LEGAL GUARDIANS. THE PROGRAM ENSURES CHILDREN RECEIVE ESSENTIAL SERVICES INCLUDING HOUSING, MEDICAL CARE, EDUCATION, AND MENTAL HEALTH SUPPORT WHILE IDENTIFYING AND VETTING SUITABLE SPONSORS THROUGH COMPREHENSIVE BACKGROUND CHECKS. THE PRIMARY OBJECTIVE IS TO SAFELY REUNITE CHILDREN WITH VETTED SPONSORS IN THE LEAST RESTRICTIVE ENVIRONMENT WHILE MAINTAINING ONGOING CASE MANAGEMENT AND SUPPORT SERVICES.

HEALTH EFFECTS RESEARCH

THE IMPACT OF DIFFUSE MILD BRAIN INJURY ON CLINICAL OUTCOMES IN CHILDREN

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

THE NEW MEXICO HEALTH INFORMATION COLLABORATIVE (NMHIC) STATEWIDE HIE EXPANSION PROJECT NMHIC, THE NEW MEXICO SDE, IS O

PHASE III COBRE: MULTIMODAL IMAGING OF NEUROPSYCHIATRIC DISORDERS (MIND)

IMPROVE EXISTING AIRPORT

NEW MEXICO REGIONAL CENTER

NEW AWARD OBLIGATING $4,003,356 IN FUNDING WITH A 36 MONTH PERIOD OF PERFORMANCE. SEE TERMS AND CONDITIONS AND SOO BELOW.

CAPACITY ENHANCEMENT OF ECOWAS EARLY WARNING AND RESPONSE DIRECTORATE

RESIDENTIAL TRANSITIONAL FOSTER CARE SERVICES FOR UNACCOMPANIED CHILDREN-LICENSED AND TEXAS-EXEMPT AND FLORIDA-DELICENSED ONLY

NEW AWARD INCREMENTALLY FUNDING $757,088 (OUT OF $800K); $415,610 IN FY18/19 NADR CWD OCO AND $341,478 IN RRF FUNDS FOR LIBYA. TERMS AND COND. BELOW

FACTORS FOR EPIGENETIC SILENCING OF LUNG CANCER GENES

NEW AWARD OBLIGATING $1,300,000 IN FY20/21 NADR-CWD GLOBAL FUNDS. INCR FUNDED. POP 18 MONTHS. SEE TERMS AND CONDITIONS BELOW.

INDIAN HSG BLOCK GR

TO PROVIDE VITAL MULTISECTORAL HUMANITARIAN ASSISTANCE FOR INTERNALLY DISPLACED PEOPLE (IDP) FROM CONFLICT AFFECTED POPULATIONS IN DRC.

BIOMARKERS TO ASSESS SELENIUM CHEMOPREVENTION FOR NSCLC

CONVENTIONAL WEAPONS DESTRUCTION IN BOSNIA AND HERZEGOVINA

DNA REPAIR CAPACITY ASSAYS FOR LUNG DISEASE RISK ASSESSMENT

TO ESTABLISH AND/OR IMPROVE AND STANDARDIZE INFORMATION SHARING POLICIES AND PROCEDURES AT NCCRMS, ECOWARN, AND AU CEWS TO ENHANCE CAPACITY OF AFRICA

NEW AWARD OBLIGATING $2,500,000 IN FY 20/21 NADR-CWD KYRGYZSTAN GLOBAL FUNDS. INCR FUNDED. POP 24 MONTHS. SEE TERMS AND CONDITIONS BELOW.

CONSOLIDATED TREATMENT SERVICES (CTS) - PEOPLE WITH IDEAS OF LOVE, LIBERTY, ACCEPTANCE AND RESPECT (PILLAR) IS A NON-PROFIT MENTAL HEALTH ORGANIZATION AND LICENSED SUBSTANCE ABUSE TREATMENT FACILITY, WHOSE GOAL IS TO PROVIDE COMPREHENSIVE BEHAVIORAL HEALTH CARE AND INCREASE ACCESS TO TREATMENT SERVICES IN THE CITY OF LAREDO, TEXAS. PILLAR PROPOSES TO IMPLEMENT PROJECT CONSOLIDATED TREATMENT SERVICES (CTS) TO ESTABLISH A CERTIFIED COMMUNITY BEHAVIORAL HEALTH CLINIC (CCBHC) OFFERING INTEGRATED AND COLLOCATED BEHAVIORAL HEALTH, SUBSTANCE ABUSE, PRIMARY CARE, AND 24-HOUR CRISIS INTERVENTION SERVICES. THE PROGRAM WILL TARGET INDIVIDUALS WITH SERIOUS MENTAL ILLNESS OR SUBSTANCE USE DISORDERS; CHILDREN AND ADOLESCENTS WITH SERIOUS EMOTIONAL DISTURBANCE; AND INDIVIDUALS WITH CO-OCCURRING MENTAL AND SUBSTANCE DISORDERS. WEBB COUNTY, COMPRISED OF PRIMARILY RURAL TO SEMI-RURAL COMMUNITIES, EXPERIENCES MAJOR GAPS IN FUNDING AVAILABLE FOR SOCIAL SERVICE AGENCIES, DRUG ABUSE PROGRAMS, AND MENTAL HEALTH SERVICES (WEBB COUNTY COMMUNITY NEEDS ASSESSMENT, 2018). PROJECT CTS WILL ACHIEVE THE GOALS AND OBJECTIVES BY RECRUITING, HIRING/ASSIGNING AND TRAINING COMPETENT, PROFESSIONAL, AND MULTIDISCIPLINARY TEAM: PSYCHIATRIST, PATIENT NAVIGATORS/CASE MANAGERS, LICENSED PROFESSIONAL COUNSELORS, SUBSTANCE ABUSE COUNSELORS, PSYCHIATRIC NURSE PRACTITIONER, PEDIATRIC NURSE PRACTITIONER, REGISTERED NURSE AND VOCATIONAL NURSES, AND DIETICIAN. PILLAR WILL ALSO HIRE AN EXTERNAL EVALUATOR (META). PROJECT CTS WILL ACHIEVE THE FOLLOWING MEASURABLE GOALS: 1) BY JANUARY 30, 2021, HIRING PROFESSIONAL TREATMENT STAFF AND CREATE PARTNERSHIPS WITH LOCAL LAW ENFORCEMENTS. 2) BY NOVEMBER 30, 2021, ESTABLISH THE CTS ADVISORY WORK GROUP (AWG) 3) BY JANUARY 15, 2021, ACHIEVE CERTIFIED COMMUNITY BEHAVIORAL HEALTH CENTER WITH COLLOCATED AND INTEGRATED MENTAL HEALTH, BEHAVIORAL HEALTH, AND PRIMARY CARE SERVICES. 4) BY THE END OF JANUARY 2021, DEVELOP AND IMPLEMENT A CRISIS INTERVENTION TEAM PROGRAM, TO INCLUDE TRAINING CURRICULUM AND LAW ENFORCEMENT PARTICIPATION. 5) BY SEPTEMBER 2022, TRAIN 150 LAW ENFORCEMENT OFFICERS IN CRISIS INTERVENTION STRATEGIES 6) BY SEPTEMBER 2022, ENROLL 400 ADULTS AND 150 ADOLESCENTS INTO TREATMENT SERVICES. PROJECT CTS WILL UTILIZED COGNITIVE BEHAVIORAL THERAPY, THE MATRIX MODEL, INTEGRATED TREATMENT FOR DUALLY DIAGNOSED AND TRAUMA RECOVERY AND EMPOWERMENT MODEL FOR WOMEN AND MEN IN ORDER TO ACHIEVE ITS ULTIMATE GOAL OF HELPING PARTICIPANTS ACHIEVE SOBRIETY, SOCIAL CONNECTEDNESS, AND IMPROVE THE OVERALL QUALITY OF LIFE.

HIS REQUISITION IS FOR A NEW OBLIGATION OF $2,500,000 IN FY 2021 IDA FUNDING TO PEOPLE IN NEED IN ETHIOPIA. THE AWARD TO PEOPLE IN NEED WILL PROVIDE MULTI-SECTORAL LIFE-SAVING ASSISTANCE TO RESPOND TO THE ACUTE NEEDS OF THE MOST VULNERABLE IDPS AND RETURNEES IN GUJI AND WEST GUJI ZONES, OROMIYA, AND IN KONSO, ALLE, DERASHE, AND SNNPR, IN ETHIOPIA.

AROUND THE CLOCK CRISIS PREVENTION & STABILIZATIONA COMPREHENSIVE 24/7 CRISIS PREVENTION AND TREATMENT CENTER THAT ADDRESS SUBSTANCE MISUSE MENTAL AND PHYSICAL HEALTH. - FHLOC IS A BEHAVIORAL HEALTH CLINIC LICENSED BY THE STATE OF MICHIGAN. THROUGH OUR COMPREHENSIVE 24/7 AROUND THE CLOCK CRISIS PREVENTION & STABILIZATION PROGRAM, WE PROVIDE EVIDENCE-BASED OUTPATIENT TREATMENT FOR INDIVIDUALS WITH SUBSTANCE USE DISORDER, OPIOID USE DISORDER, MENTAL HEALTH AND CO-OCCURRING DISORDER. WE ALSO SERVICE VETERANS AND CHILDREN AND ADOLESCENTS W/SED. WE ARE TEAMED WITH HOSPITAL EMERGENCY ROOMS TO REDUCE RECIDIVISM OF NON-LIFE-THREATENING MENTAL HEALTH AND DRUG RELATED ISSUES TO ALLOW FOR THE TREATMENT OF THOSE WITH LIFE-ALTERING EMERGENCIES. WE ARE LOCATED IN DETROIT, WAYNE COUNTY AND EXPECT TO SERVE MENTAL HEALTH AND SUBSTANCE MISUSE CONSUMERS FROM THE SURROUNDING COUNTIES, INCLUDING: OAKLAND, MACOMB, WASHTENAW, LIVINGSTON, AND MONROE. WE WILL INCREASE THE NUMBER OF CONSUMERS IN TREATMENT FOR SUD, OUD, SMI, AND SED, BY SERVING 150 NEW CLIENTS IN THE FIRST YEAR, OPEN A NEW FACILITY BY THE START OF THE SECOND YEAR, AND SERVE AN ADDITIONAL 300 UNDUPLICATED CLIENTS FROM TWO LOCATIONS BY THE END OF THE SECOND YEAR. THE MOST FUNDAMENTAL MEASUREMENT OF THE PROJECT SUCCESS IS TO INCREASE ACCESS TO AND IMPROVE THE QUALITY OF COMMUNITY MENTAL HEALTH AND SUBSTANCE USE DISORDER TREATMENT SERVICES BY PROVIDING PERSON AND FAMILY CENTERED INTEGRATED SERVICES ON DAY ONE. WE WILL BECOME A CERTIFIED COMMUNITY BEHAVIORAL HEALTH CLINIC WITHIN FOUR MONTHS OF FUNDING AND BEGIN ON-SITE MEDICATION ASSISTED TREATMENT BY TELEMEDICINE WITH THE PRESCRIBING OF BUPRENORPHINE WITHIN 30 DAYS. OUR COUNSELORS AND MEDICAL TEAM WILL REDUCE THE NUMBER OF UNTREATED PERSONS WITH SUD, OUD, SMI, AND SED BY STABILIZING 70% OF NEW CLIENTS WITHIN 90 DAYS AND 85% OF CLIENTS IN PROGRAM FOR SIX MONTHS, WILL BE FREE FROM ILLICIT DRUG USE. WE WILL IMPROVE THE POSITIONING OF CLIENTS IN THE PROGRAM FOR 12 MONTHS BY INCREASING SCORES AS MEASURED BY ASAM AND THE STAGES OF CHANGE IN RELATION TO CLIENTS TREATMENT PLAN GOALS, FROM LOW, MEDIUM, TO HIGH. WE ARE ALSO TEAMED WITH CONNER CREEK SOLUTIONS FOR DETOX SERVICES AND NEW LIGHT RECOVERY CENTER FOR METHADONE MAINTENANCE. OUR GOAL IS TO ADDRESS THE TOTAL NEED OF OUR CLIENTS THROUGH PEER SUPPORT, RESUME BUILDING, JOB TRAINING AND PLACEMENT, AS WELL AS, LIFE SKILLS ENHANCEMENT AND LIFE COACHING WORKSHOPS. TRANSPORTATION IS PROVIDED TO AND FROM CLINICAL APPOINTMENTS AND DOSING FACILITIES, AS WELL AS, FROM THE EMERGENCY ROOM TO FHLOC, WHERE WE PROVIDE A COMFORTABLE PLACE TO TRANSITION THROUGH THE RECOVERY PROCESS WITH TEMPORARY SHELTER, FOOD, SHOWER, AND A CHANGE OF CLOTHES. WE WILL HAVE A NURSE PRACTITIONER AND MEDICAL ASSISTANT ON SITE TO ADDRESS PHYSICAL HEALTH NEEDS AND LICENSED COUNSELORS, TELEPSYCHIATRY FOR MENTAL HEALTH NEEDS, AS WELL AS CASE MANAGEMENT TO LINK CONSUMERS TO REFERRAL SERVICES. SECURITY IS ANOTHER A BIG PART OF OUR SERVICES TO ENSURE THE SAFETY OF OUR STAFF AND CLIENTS IN THE EVENT OF ANY UNFORESEEN CIRCUMSTANCES. OUR CRISIS TEAMS ARE MOBILE AND WILL MAKE HOME VISITS.

APPLICATION PURPOSE: THE PURPOSE OF THIS AWARD IS TO USE FFY24 5339(B) BUS AND BUS FACILITIES COMPETITIVE FUNDS FOR THE CONSTRUCTION OF PHASE 2 OF THE COLT NORTH TRANSIT CENTER.; ACTIVITIES PERFORMED: PHASE 2 CONSISTS OF THE FINAL DESIGN ENGINEERING AND CONSTRUCTION OF A PERMANENT TRANSIT BUILDING AT THE CURRENT TRANSIT CENTER SITE.; EXPECTED OUTCOMES: THIS FACILITY WILL BE THE FIRST MAJOR INFRASTRUCTURE IN THE LOVELAND TRANSIT SYSTEM PROVIDING IMPROVED SAFETY DIRECT ACCESS TO CUSTOMER SERVICE HELP TO MITIGATE TRAFFIC CONGESTION FOR OUR HEAVILY TRAFFICKED CORRIDORS AND PROVIDE A SHELTER FOR CUSTOMERS ALL OF WHICH WILL DRAW NEW USERS.; INTENDED BENEFICIARIES: PASSENGERS AND BUS OPERATORS OF BOTH CITY OF LOVELAND TRANSIT (COLT) AND TRANSFORT REGIONAL ROUTES AS WELL AS THE GENERAL PUBLIC CHOOSING TO USE PUBLIC TRANSIT; SUBRECIPIENT ACTIVITIES: THERE ARE NO SUB-RECIPIENT ACTIVITIES ASSOCIATED WITH THIS AWARD.

NEW AWARD. INCREMENTALLY FUNDING $500,000 IN FY20/21 BILATERAL FUNDS.

ALCOHOL DEPENDENCE: INTEGRATING GENETIC & FMRI METHODS

INHALED DELIVERY OF VIDAZA FOR TARGETED EPIGENETIC LUNG CANCER THERAPY

RYAN WHITE TITLE III: EARLY INTERVENTION SERVICES

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

MINE/ERW CLEARANCE AND CONVENTIONAL WEAPONS DESTRUCTION IN CROATIA

PURPOSE: CORONAVIRUS AID, RELIEF, AND ECONOMIC SECURITY ACT FUNDS AWARDED AS ECONOMIC RELIEF U.S. AIRPORTS AFFECTED BY THE PREVENTION OF, PREPARATION FOR, AND RESPONSE TO THE COVID-19 PANDEMIC. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A 30,000 SQUARE FOOT TERMINAL BUILDING TO MEET DESIGN CURRENT BUILDING CODES AND AMERICANS WITH DISABILITIES ACT DESIGN STANDARDS. THIS GRANT FUNDS THE FINAL PHASE, WHICH CONSISTS OF 7,777 SQUARE FEET OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH LOVELAND, COLORADO.

MINDFULNESS FOR ALCOHOL ABUSING OFFENDERS: MECHANISMS AND OUTCOMES

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

NEW AWARD OBLIGATING $1,475,000. $475,000 IN FY20/21 & $1,000,000 IN FY 21/22 NADR-CWD SERBIA BILATERAL FUNDS. SEE TERMS AND CONDITIONS

BRAIN CHANGES AND OUTCOMES ACCOMPANYING EVIDENCE-BASED TREATMENT IN HIGH-RISK YOUTH

GENETIC AND EPIGENETIC BIOMARKERS FOR SCC OF THE LUNG

SOCIOEMOTIONAL PROCESSING AND AGGRESSION

HOTSPOTS CLEARANCE AND VICTIM ASSISTANCE IN ALBANIA

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

SOCIO-MORAL PROCESSING IN PSYCHOPATHY AND SUBSTANCE ABUSE

EXTERNALIZING OUTCOMES IN HIGH RISK YOUTH

HISTONE METHYLTRANSFERASES AS A TARGET FOR LUNG CANCER PREVENTION

NEUROCOGNITIVE ABNORMALITIES IN STIMULANT ABUSE AMONG HIGH-RISK WOMEN - PROJECT ABSTRACT THERE CONTINUES TO BE GREAT INTEREST AND PUBLIC/HEALTH/RELEVANCE WITH REGARD TO UNDERSTANDING THE NEUROBIOLOGICAL SYSTEMS THAT UNDERLIE THE COMORBIDITY OF SUBSTANCE USE DISORDERS AND OTHER PSYCHIATRIC CONDITIONS. IN A PREVIOUS R01 AWARD, WE FOCUSED OUR EFFORTS UPON CHARACTERIZING THE NEURAL CIRCUITRY UNDERLYING MORAL DECISION MAKING IN INCARCERATED MEN WITH VARYING LEVELS OF TWO FREQUENTLY CO-OCCURRING CONDITIONS: STIMULANT ABUSE AND PSYCHOPATHY. HERE WE PROPOSE TO EXTEND THIS WORK TO INCARCERATED WOMEN, EXAMINE LONGITUDINAL OUTCOMES, AND APPLY STATEOF-THE-ART NETWORK ANALYSES FOR PREDICTIVE MODELS. STUDIES PUBLISHED BY OUR RESEARCH TEAM HAVE DEMONSTRATED SEX DIFFERENCES IN THE DEGREE AND EXPRESSION OF PSYCHOPATHIC TRAITS, PATTERNS OF STIMULANT ABUSE, AND MORAL DECISION-MAKING. HOWEVER, THE NEURAL CIRCUITRY THAT UNDERLIES THESE SEX DIFFERENCES IS NOT WELL UNDERSTOOD. WE HAVE ALSO IDENTIFIED SUBSTANTIAL SEX DIFFERENCES IN REGIONAL GRAY MATTER VOLUME AND DENSITY IN OUR EXTANT SAMPLES. COLLECTIVELY, SEX DIFFERENCES IN PATHOPHYSIOLOGY COULD HAVE SIGNIFICANT IMPLICATIONS FOR TREATMENT STRATEGIES AND DIFFERENTIAL BIOMARKERS OF TREATMENT PREDICTION AND OUTCOME IN MEN AND WOMEN. WE WILL IMPLEMENT THE RESEARCH STRATEGY WITH A LARGE INCARCERATED POPULATION BY DEPLOYING A UNIQUE MOBILE MRI SCANNER TO THE REGIONAL WOMEN’S PRISON. PARTICIPANTS WILL BE STRATIFIED BY THEIR LEVEL OF LIFETIME STIMULANT (COCAINE, AMPHETAMINE) USE SEVERITY AND PSYCHOPATHIC TRAITS (HIGH, MEDIUM, LOW) AND WILL UNDERGO ANATOMICAL AND FUNCTIONAL MRI SCANNING WHILE COMPLETING MULTI-MODAL (I.E., LINGUISTIC AND PICTURE) DECISION-MAKING TASKS. WE WILL ALSO EXAMINE FUNCTIONAL NETWORK AND DYNAMIC NETWORK CONNECTIVITY IN WOMEN USING A NEW MULTIBAND EPI PULSE SEQUENCE, AND COLLECT LONGITUDINAL OUTCOMES AFTER RELEASE TO THE COMMUNITY AND TEST BEHAVIORAL AND NEUROPREDICTIVE MODELS OF RELAPSE AND FUTURE ANTISOCIAL BEHAVIOR. THIS WORK IS EXPECTED TO GENERATE A LARGE, ROBUST DATASET THAT CHARACTERIZES THE OVERLAPPING AND UNIQUE ASPECTS OF NEURAL CIRCUITRY UNDERLYING STIMULANT USE AND PSYCHOPATHY IN FEMALES. THE PROPOSED RESEARCH IS IN LINE WITH RECENT PRIORITIES EMPHASIZED BY NIDA FOR PROJECTS AIMED AT EXAMINING GENDER DIFFERENCES, AND EFFECTS SPECIFIC TO FEMALES, TO IMPROVE OUR UNDERSTANDING OF THE NATURE AND ETIOLOGY OF DRUG ABUSE.

THE COGNITIVE NEUROSCIENCE OF FEMALE PSYCHOPATHY

EPIGENETIC CHANGES LINK COPD AND LUNG CANCER

A LONGITUDINAL STUDY OF TRAUMATIC BRAIN INJURY IN A HIGH-RISK POPULATION - PROJECT SUMMARY/ABSTRACT TRAUMATIC BRAIN INJURY (TBI) IS A GLOBAL CONCERN THAT PRECIPITATES A DIVERSE SET OF HEALTH CONSEQUENCES. TBI IS A MAJOR CONCERN IN FORENSIC POPULATIONS -- AN ISSUE RECENTLY HIGHLIGHTED BY CALLS FOR RESEARCH BY NATIONAL PUBLIC HEALTH INSTITUTIONS [1]. INDEED, UPWARDS OF 60% OF INMATES HAVE A HISTORY OF TBI, A RATE SEVEN TIMES HIGHER THAN THE GENERAL POPULATION (8.5%) [2, 3]. TBI IS A CRIMINOGENIC RISK FACTOR [3, 4] AND EVEN MILD TBI INCREASES THE RATES OF RISK-TAKING BEHAVIOR, SUBSTANCE USE, AND FUTURE OFFENDING [2, 4]. OVER THE LAST DECADE OUR TEAM HAS BEEN CONTINUOUSLY FUNDED BY NIH TO COLLECT DETAILED CLINICAL AND NEUROIMAGING PROTOCOLS FROM OVER 4000 INCARCERATED MEN AND WOMEN. WE UTILIZE A UNIQUE PAIR OF TWIN MOBILE MRI UNITS THAT ARE DEPLOYED DIRECTLY ON THE SECURE GROUNDS OF FORENSIC FACILITIES, MAKING IT POSSIBLE TO CONDUCT THIS RESEARCH. OUR DATASET INCLUDES MULTIMODAL NEUROIMAGING PROTOCOLS, THOROUGH CLINICAL ASSESSMENT, NEUROPSYCHOLOGICAL EVALUATIONS, AND HISTORIES OF TBI. ALL OF OUR N>4000 OFFENDERS HAVE CONSENTED TO PARTICIPATE IN LONGITUDINAL FOLLOW-UP STUDIES. FOR THIS PROJECT, WE WILL COMMENCE A LONGITUDINAL STUDY ON N=300 INDIVIDUALS AGED 35+, EXAMINING VARIABLES THAT WILL DIFFERENTIATE TRAJECTORIES ASSOCIATED WITH COGNITIVE IMPAIRMENTS. WE WILL ALSO LEVERAGE ADVANCED NEUROIMAGING TOOLS DEVELOPED BY OUR TEAM TO PROVIDE BRAIN-BASED MEASURES OF COGNITIVE DECLINE AND IMAGING-BASED CLASSIFICATION TOOLS FOR IDENTIFYING BRAIN INJURIES AND COMORBID CONDITIONS (I.E., SUBSTANCE ABUSE, PSYCHOPATHY SCORES, DEPRESSION, ETC.). WE WILL ALSO EXAMINE HOW THE BRAIN INJURY PROFILES AND COMORBID CONDITIONS CHANGE OVER TIME. THE AVAILABILITY OF THESE UNIQUE RESOURCES TO EXAMINE THIS HIGHLY UNDERSERVED POPULATION MAKES THIS AN EXCITING PROJECT WITH THE POTENTIAL TO BREAK NEW GROUND IN OUR UNDERSTANDING OF INDIVIDUAL RISK NEEDS AND DIVERGENT OUTCOMES IN TBI AND NEURODEGENERATIVE DISEASE.

CONVENTIONAL WEAPONS DESTRUCTION AND PHYSICAL SECURITY AND STOCKPILE MANAGEMENT IN MONTENEGRO

RYAN WHITE TITLE III: EARLY INTERVENTION SERVICES

INDIAN HSG BLOCK GR

WORLD LANGUAGE ADVANCEMENT & READINESS

TO PROVIDE MULTIPURPOSE CASH, NUTRITION, HEALTH, WATER, SANITATION, AND HYGIENE, AND AGRICULTURE SECTOR ACTIVITIES TO VULNERABLE POPULATIONS IN THE DEMOCRATIC REPUBLIC OF THE CONGO.

EMERGENCY HEALTH, NUTRITION, WASH, AND MPCA SUPPORT IN DRC

ATTENDING TO ALL CHILDREN: EXAMINING THE ROLE OF ALPHA OSCILLATIONS IN ATTENTION IN YOUNG CHILDREN WITH AND WITHOUT PRENATAL ALCOHOL EXPOSURE (ASCEND) - ABSTRACT ATTENTION DEFICITS CAUSE LIFE-LONG CHALLENGES AFFECTING ACADEMIC AND JOB PERFORMANCE, SOCIAL RELATIONSHIPS, AND LIFE SATISFACTION. ATTENTION PROBLEMS TYPICALLY BEGIN AT AN EARLY AGE AND CHILDREN WITH ATTENTION PROBLEMS STRUGGLE IN SCHOOL. IDEALLY, ATTENTION DEFICITS WOULD BE IDENTIFIED BEFORE A CHILD ENTERS SCHOOL. A PRIMARY LIMITATION IN THE FIELD IS OUR LIMITED KNOWLEDGE OF THE NEURAL SIGNATURES OF ATTENTION IN YOUNG CHILDREN. CHILDREN WITH PRENATAL ALCOHOL EXPOSURE (PAE) AND CHILDREN WITH A DIAGNOSIS OF FETAL ALCOHOL SPECTRUM DISORDER (FASD) RELATED TO PAE EXPERIENCE PERSISTENT ATTENTION DEFICITS, AND PAE IS PRESENT AT BIRTH. THEREFORE, STUDYING CHILDREN WITH AND WITHOUT PAE PROVIDES US WITH AN OPPORTUNITY TO EXAMINE NEURAL SIGNATURES OF ATTENTION AT A YOUNG AGE IN A GROUP OF CHILDREN AT HIGH RISK OF ATTENTION DEFICITS. CHILDREN RAISED IN LOWER SOCIOECONOMIC HOUSEHOLDS ARE ALSO AT GREATER RISK OF ATTENTION PROBLEMS, AND DUE TO HIGH RATES OF POVERTY IN NEW MEXICO, WE ARE WELL-POSITIONED TO EXAMINE ITS ROLE IN ATTENTION IN CHILDREN WITH AND WITHOUT PAE. RESEARCH IN ADULTS INDICATES THAT ALPHA OSCILLATIONS PLAY A KEY ROLE IN DIRECTING ATTENTION, BUT IT IS UNKNOWN HOW ALPHA OSCILLATIONS ARE RELATED TO ATTENTION EARLY IN DEVELOPMENT. ALPHA OSCILLATIONS ARE EASILY ELICITED DURING REST, MODIFIED DURING TASKS, AND MEASURABLE ACROSS DEVELOPMENT. THIS STUDY BUILDS ON (1) PRIOR RESEARCH DEMONSTRATING THALAMUS DRIVES SOME CORTICAL ALPHA OSCILLATIONS WHEREAS OTHERS ARE DRIVEN BY CORTICO-CORTICAL CONNECTIONS OR LOCAL NETWORK DYNAMICS AND (2) STUDIES IN PRECLINICAL PAE MODELS AND RESEARCH IN CHILDREN WITH PAE INDICATING DISRUPTED CORTICO- THALAMIC AND CORTICO-CORTICAL TRACTS WITH PAE. AIM 1 WILL ESTABLISH THE ROLE OF ALPHA OSCILLATIONS AND CORTICO- THALAMIC OR CORTICO-CORTICAL CONNECTIVITY IN ATTENTION BY MEASURING ALPHA OSCILLATIONS DURING REST AND TASK USING MAGNETOENCEPHALOGRAPHY (MEG) AND WHITE MATTER INTEGRITY (WMI) USING DIFFUSION TENSOR IMAGING (DTI) IN TYPICALLY DEVELOPING CHILDREN AGED 4-7 YEARS. AIM 2 WILL ASSESS ALTERATIONS IN ALPHA OSCILLATIONS AND WMI AND THEIR RELATION TO ATTENTION DEFICITS IN CHILDREN WITH PAE, RELATIVE TO TYPICALLY DEVELOPING CHILDREN. AIM 3 WILL EXAMINE THE DEVELOPMENTAL TRAJECTORY OF ALPHA OSCILLATIONS AND WMI AND THEIR ROLE IN ATTENTION BY FOLLOWING THE SAME CHILDREN LONGITUDINALLY UNTIL AGE SEVEN. WE HYPOTHESIZE THAT ALPHA OSCILLATIONS ARE DIRECTLY RELATED TO WMI AND ATTENTION IN TYPICALLY DEVELOPING CHILDREN. FURTHERMORE, ALPHA OSCILLATIONS WILL BE REDUCED IN CHILDREN WITH PAE, AND THESE REDUCTIONS WILL BE RELATED TO DISRUPTIONS IN WMI AND ATTENTION DEFICITS. WE EXPECT THESE EFFECTS TO BE MEDIATED BY POVERTY IN BOTH TYPICALLY DEVELOPING CHILDREN AND CHILDREN WITH PAE. WE WILL TEST OUR HYPOTHESES BY MEASURING ALPHA OSCILLATIONS USING MEG DURING 3 TASKS THAT ROBUSTLY MANIPULATE ALPHA OSCILLATIONS IN PARIETAL CORTEX, SOMATOMOTOR REGIONS AND THE FRONTO-PARIETAL NETWORK AND EXAMINING HOW THESE OSCILLATIONS RELATE TO WMI AND ATTENTION. THIS STUDY WILL PROVIDE FOUNDATIONAL KNOWLEDGE ABOUT THE ROLE OF ALPHA OSCILLATIONS IN ATTENTION IN YOUNG CHILDREN AND MAY INDICATE POTENTIAL BIOMARKERS TO IMPROVE EARLY DIAGNOSIS AND INTERVENTION FOR FASD TO INFORM OUR UNDERSTANDING OF ATTENTION DEFICITS BROADLY.

HOTSPOTS CLEARANCE IN ALBANIA - TOWARDS COMPLETION

HIV-ASSOCIATED CHRONIC OBSTRUCTIVE PULMONARY DISEASE

LOW COST AUTOMATED ULTRASOUND FOR BREAST CANCER DETECTION AND DIAGNOSIS

WEAPONS REMOVAL & ABATEMENT GRANTS PROJECT: GLOBAL

EFFECTIVENESS OF VARENICLINE: TESTING INDIVIDUAL DIFFERENCES

DEMINING AND VICTIMS ASSISTANCE

ACTION MONITORING ACTION OBSERVATION AND DOPAMINE GENES AS PREDICTORS OF SUBSTAN

HEALTH CARE AND OTHER FACILITIES

MECHANISM AND COUNTERMEASURE OF FENTANYL-INDUCED SUDDEN DEATH - PROJECT SUMMARY OPIOIDS WERE INVOLVED IN 75,673 OVERDOSE DEATHS IN 2020 IN THE U.S. FENTANYL, AN OPIOID MU-RECEPTOR (MOR) AGONIST ACTING ON CENTRAL MORS PRODUCES ANALGESIA, BUT DEPRESSES VENTILATION THAT COULD BE LETHAL. RAPID INTRAVENOUS INJECTION OF OVERDOSE FENTANYL, PARTICULARLY IN ILLICIT USE, IS THE DEADLIEST. IT TRIGGERS AN APNEA LEADING TO SUDDEN DEATH WITHIN MINUTES IN ~1/3 OF ADULTS (MALE > FEMALE) WITH ~75% OF FENTANYL SEQUESTERED BY THE LUNGS AFTER INJECTION. NALOXONE IS THE PREFERABLE TREATMENT FOR POST-OVERDOSE, BUT NOT VIABLE FOR THE ILLICIT FNT USERS WHO ARE FOUND PULSELESS UPON THE ARRIVAL OF EMERGENCY MEDICAL SERVICES. MOREOVER, NALOXONE COUNTERACTS ANALGESIA WITH POTENTIALLY LIFE-THREATENING SIDE EFFECTS. CENTRAL APNEA, UPPER AIRWAY OBSTRUCTION, AND CHEST WALL RIGIDITY ARE ASSUMED TO BE ACCOUNTABLE FOR THE SUDDEN DEATH, BUT THE EXACT CAUSE OF THE DEATH AND THE EFFECTIVE COUNTERMEASURE REMAIN UNKNOWN, CONSTITUTING A CRITICAL AND UNMET THERAPEUTIC CLINICAL NEED. BRONCHOPULMONARY C-FIBERS (PCFS) ARE THE MAJOR SENSORY NERVE ENDINGS INNERVATING THE AIRWAYS AND LUNGS AND CRUCIAL IN THE CONTROL OF RESPIRATORY RHYTHM. PCF STIMULATION COULD ELICIT CENTRAL APNEA AND VOCAL CLOSURE LIKELY BY PROMOTING RELEASE OF GLUTAMATE OR SUBSTANCE P TO ACTIVATE PCF 2ND-ORDER NEURONS IN THE NUCLEUS TRACTUS SOLITARIUS VIA AMPA AND NEUROKININ-1 RECEPTOR. WE HAVE REPORTED THAT INTRAVENOUS BOLUS INJECTION OF A LOW DOSE FENTANYL TRIGGERS A PCF-MEDIATED BRIEF APNEA, CONSISTENT WITH PREVIOUSLY REPORTED EXCITATION OF DORSAL ROOT GANGLION C- NEURONS BY MOR AGONISTS VIA GS-CAMP PATHWAY. OUR PRELIMINARY DATA SHOW A TRIPLE APNEA (CENTRAL APNEA, VOCAL CLOSURE AND LARYNGEAL CONSTRICTION/COLLAPSE) COUPLED WITH CHEST WALL RIGIDITY, RESULTING IN DEATH WITHIN MINUTES IN ANESTHETIZED ADULT RATS AFTER OVERDOSE FENTANYL IS RAPIDLY INJECTED. IN THIS PROPOSAL, WE SEEK TO ESTABLISH THE FIRST ANIMAL MODEL OF FENTANYL-INDUCED SUDDEN DEATH FOLLOWING TRIPLE APNEA IN AWAKE ADULT RATS AND DETERMINE THE DEPENDENCY OF TRIPLE APNEA (DEATH) ON THE GENDER AND PERIPHERAL (ESPECIALLY VAGAL) MORS/Μ1RS (AIM 1). WE WILL FURTHER DEMONSTRATE THAT FENTANYL DIRECTLY STIMULATES PCFS TO EVOKE TRIPLE APNEA BY ACTING ON MOR/Μ1R AND GS- CAMP PATHWAY, THEREBY PROMOTE PCF RELEASE OF GLUTAMATE AND SP TO ACTIVATE THE 2ND-ORDER NEURONS (AIM 2). OUR PILOT STUDY HAS SHOWN THAT INTRAVENOUS INJECTION OF DERMORPHIN (A PERIPHERALLY ACTING MOR AGONIST) INDUCES MOR INTERNALIZATION IN VAGAL SENSORY NEURONS AND BLOCKS FENTANYL-INDUCED TRIPLE APNEA. THE SS-ARRESTIN-MEDIATED SIGNALING IS KNOWN TO BE RESPONSIBLE FOR MOR DESENSITIZATION/INTERNALIZATION. WE WILL DEFINE THAT DIAMORPHINE HAS LIMITED IMPACT ON BASELINE CARDIORESPIRATORY ACTIVITY, BUT INTERNALIZES PCFS' MORS/Μ1RS VIA ACTIVATION OF SS- ARRESTIN-SIGNALING TO PREVENTS THE TRIPLE APNEA (DEATH) WITH NO CHANGE IN ANALGESIA. THIS WILL PRESENT A POTENTIAL SAFER AND TRANSLATIONAL PRETREATMENT FOR OVERDOSE FENTANYL IN CLINICAL SETTINGS (AIM 3). A MULTIDISCIPLINARY APPROACH (ELECTROPHYSIOLOGY, IMMUNOHISTOCHEMISTRY, PHARMACOLOGY AND BIOCHEMISTRY) AT SYSTEMIC AND CELLULAR LEVELS WILL BE APPLIED TO ELUCIDATE THE MECHANISMS UNDERLYING NOT ONLY TRIPLE APNEA (DEATH) BUT ALSO THE LACK OF TRIPLE APNEA AFTER DERMORPHIN PRETREATMENT. THE EXPECTED DATA WILL, FOR THE FIRST TIME, MECHANISTICALLY REVEAL THE KEY ROLE OF PCFS IN GENERATING FENTANYL-INDUCED TRIPLE APNEA AND PROVIDE A NOVEL AND POTENTIAL COUNTERMEASURE OF DERMORPHIN PRETREATMENT TO PREVENT/DIMINISH THE SUDDEN DEATH.

AWARDING $1,266,256 OF NADR-CWD FUNDS TO ITF IN SERBIA FOR 24 MONTHS. PRE-AWARD COSTS NOT APPROVED. SEE TERMS AND CONDITIONS BELOW.

CAPACITY SUPPORT OF LIBYAN CENTER FOR MINE ACTION AND REMNANTS OF WAR IN SECURING AND ELIMINATING CONVENTIONAL WEAPONS IN LIBYA

MICROBIOME-GUT-BRAIN DYSFUNCTION IN PRODROMAL AND SYMPTOMATIC LEWY BODY DISEASES - PROJECT SUMMARY/ABSTRACT COGNITIVE DECLINE IN LEWY BODY DEMENTIAS [PARKINSON’S DISEASE DEMENTIA (PDD) AND DEMENTIA WITH LEWY BODIES (DLB); A CATEGORY OF ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (ADRD)], CAUSES SIGNIFICANT FUNCTIONAL IMPAIRMENT AND DOES NOT RESPOND WELL TO EXISTING TREATMENTS. PERHAPS THE GREATEST CHALLENGE FOR DEVELOPING EFFECTIVE TREATMENTS IS THE LACK OF A MECHANISTIC UNDERSTANDING OF THE KEY EVENTS DRIVING PATHOPHYSIOLOGY. INCREASING EVIDENCE SUGGESTS THAT A PERTURBED GUT MICROBIOME (DYSBIOSIS) DRIVEN BY A BLOOM IN SULFATE REDUCING BACTERIA AND INCREASED INTESTINAL PERMEABILITY MAY BE KEY MECHANISMS DRIVING DISEASE PATHOGENESIS IN LEWY BODY DISEASES. THERE IS A NEED TO EVALUATE WHETHER THESE FACTORS ARE PRESENT EARLY IN THE DISEASE COURSE AND ASSOCIATED WITH KNOWN DISEASE PROCESSES, SUCH AS MIDBRAIN DEGENERATION AND CLINICAL OUTCOMES. IDIOPATHIC REM SLEEP BEHAVIOR DISORDER (IRBD), IS ONE OF THE EARLIEST AND MOST SPECIFIC PRODROMAL INDICATORS OF LEWY BODY DISEASES AS UP TO 96.6% OF IRBD PATIENTS WILL PROGRESS TO AN ALPHA-SYNUCLEINOPATHY AT 14 YEARS FOLLOW UP. THIS POPULATION THEREFORE PROVIDES AN OPPORTUNITY TO CONDUCT A NOVEL EVALUATION OF THE PRESENCE OF A BLOOM IN SRB/DYSBIOSIS AND INCREASED INTESTINAL PERMEABILITY EARLY IN THE DISEASE AND WHETHER THESE MECHANISMS ARE ASSOCIATED WITH KNOWN DISEASE PROCESSES (INCREASES IN A-SYNUCLEIN, MIDBRAIN DEGENERATION AND CLINICAL OUTCOMES). THE PROPOSED PROJECT WILL CONDUCT A PROSPECTIVE, CROSS-SECTIONAL STUDY TO TEST THE HYPOTHESIS THAT ABNORMAL LACTULOSE BREATH TESTS WITH ELEVATED H2S CONCENTRATION (AS A MARKER OF DYSBIOSIS AND A BLOOM OF SRB IN THE GUT) ARE PRESENT AT PRODROMAL STAGES OF THE DISEASE AND ASSOCIATED WITH INCREASES IN MARKERS OF INCREASED INTESTINAL PERMEABILITY AND MICROBIAL TRANSLOCATION OF LIPOPOLYSACCHARIDE (TOTAL BACTERIAL 16S RRNA GENE AND LIPOPOLYSACCHARIDE BINDING PROTEIN; LBP), KNOWN DISEASE PROCESSES (PLASMA CONCENTRATION OF A-SYNUCLEIN, MRI BIOMARKERS OF INTEGRITY OF SNC AND LC) AND CLINICAL OUTCOMES. WE WILL RECRUIT PRODROMAL (IRBD), SYMPTOMATIC LEWY BODY DISEASE PATIENTS (PD AND DLB) AND HC TO EVALUATE OUR HYPOTHESES. CONSISTENT WITH SEVERAL OBJECTIVES OUTLINED IN PAR-22-211, THE COMPLETION OF THE PROPOSED PROJECT WILL ADVANCE OUR MECHANISTIC UNDERSTANDING OF THE EFFECTS OF A BOOM IN SRB/DYSBIOSIS, POTENTIALLY IDENTIFYING TARGETS FOR DISEASE MODIFYING TREATMENTS. SHOULD OUR RESULTS DETERMINE AN IMPORTANT ROLE OF GUT SRB BLOOM/DYSBIOSIS IN THE PATHOPHYSIOLOGY OF LEWY BODY DISEASES, THESE MEASUREMENTS COULD BE INCORPORATED INTO ROUTINE CLINICAL PRACTICE TO SCREEN FOR EMERGING PATHOGENIC PROCESSES. NOTABLY, MANY POTENTIAL TREATMENTS TARGETING THE MICROBIOME ARE READILY AVAILABLE AND SUBSEQUENT CLINICAL TRIALS CAN EVALUATE WHETHER INTERVENTIONS TARGETING A BLOOM IN SRB/DYSBIOSIS COULD BE USED TO INTERVENE BEFORE OVERT MOTOR AND COGNITIVE SYMPTOMS DEVELOP.

BRIDGES: BRIDGING THE GAP BETWEEN BEHAVIORAL AND SEXUAL HEALTH NEEDS

EQUIPMENT: MRI: TRACK 2 MEG SYSTEM WITH INTEGRATED HELIUM RECOVERY EQUIPMENT FOR COGNITIVE NEUROSCIENCE -THE MAJOR RESEARCH INSTRUMENTATION PROJECT SUPPORTS THE ACQUISITION OF A NEW MAGNETOENCEPHALOGRAPHY (MEG) INSTRUMENT, THE MEGIN TRIUS NEO WITH AN INTEGRATED HELIUM RECYCLER. MEG IS A FUNCTIONAL BRAIN IMAGING TECHNOLOGY THAT PROVIDES EXQUISITE SENSITIVITY TO THE TIMING OF BRAIN ACTIVITY AND IS A DIRECT MEASURE OF NEURONAL CURRENTS. THE TECHNOLOGY IS COMPLEMENTARY TO OTHER NEUROIMAGING TECHNIQUES, SUCH AS FMRI, WHICH HAS HIGH SPATIAL SENSITIVITY BUT LIMITED SENSITIVITY TO RAPID CHANGES IN BRAIN DYNAMICS. THE MEG INSTRUMENTATION IS CRITICAL FOR SUPPORTING COGNITIVE NEUROSCIENCE RESEARCH. SAMPLE PLANNED PROJECTS THAT USE THE INSTRUMENT INCLUDE NEW RESEARCH TO GAIN FURTHER INSIGHT INTO THE DEVELOPMENT OF BRAIN AND BEHAVIOR IN CHILDREN, EXAMINATION OF THE DYNAMICS OF MEMORY SYSTEMS, ELUCIDATION OF HOW BRAIN STIMULATION ENHANCES BRAIN FUNCTION AND BEHAVIOR, AND INVESTIGATION OF THE ROLE OF SLEEP FOR COGNITIVE AND BEHAVIORAL OUTCOMES ACROSS THE LIFESPAN. THE MEGIN TRIUS NEO IS A HIGH-CHANNEL DENSITY, COMMERCIALLY AVAILABLE MEG SYSTEM THAT PROVIDES HIGH SENSITIVITY TO WEAK SIGNALS ALLOWING FOR MEASUREMENT OF DEEP STRUCTURES AND LOW AMPLITUDE SIGNALS. THE EQUIPMENT ALSO DRAMATICALLY REDUCES USE OF HELIUM, A LIMITED RESOURCE. BY COMBINING MEG DATA WITH STRUCTURAL INFORMATION OBTAINED WITH MAGNETIC RESONANCE IMAGING, NEW KNOWLEDGE IS OBTAINED BY UNDERSTANDING HOW BRAIN FUNCTION AND STRUCTURE RELATE TO OUTCOMES ACROSS THE POPULATION. THE GOALS OF SOME RESEARCH SUPPORTED BY THIS INSTRUMENTATION IS TRANSLATIONAL AND AIMS TO INFORM UNDERSTANDING OF THE BRAIN TO IMPROVE HEALTH AND OUTCOMES FOR ALL. OTHER RESEARCH SUPPORTED BY THIS INSTRUMENTATION USES ARTIFICIAL INTELLIGENCE TO INTERPRET THESE COMPLEX DATASETS TO ENHANCE THE UNDERSTANDING OF THE LINKS BETWEEN BRAIN AND BEHAVIOR. OVERALL, THE INSTRUMENTATION WILL PROVIDE SIGNIFICANT RESEARCH AND TRAINING OPPORTUNITIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

MINE ACTION ACTIVITIES IN BOSNIA AND HERZEGOVINA

RESOLUTION OF EPITHELIAL CELL HYPERPLASIA

AEROSOL DELIVERY OF TOPOTECAN FOR PERSONALIZED LUNG CANCER THERAPY

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

NEUROBIOLOGICAL CORRELATES OF LANGUAGE DYSFUNCTION IN AUTISM SPECTRUM DISORDERS

PURPOSE: CONSTRUCT TAXIWAY; EXPAND APRON. THIS GRANT INCLUDES FUNDING BY THE AMERICAN RESCUE PLAN ACT OF 2021 TO INCREASE THE FEDERAL SHARE TO 100 PERCENT FOR THE AIRPORT IMPROVEMENT PROGRAM (AIP). ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A 200 FOOT TAXIWAY E TO PROVIDE ACCESS TO THE COMMERCIAL SERVICE APRON. THIS PROJECT EXPANDS THE EXISTING COMMERCIAL SERVICE APRON TO 7,000 SQUARE YARDS TO MEET FEDERAL AVIATION ADMINISTRATION DESIGN STANDARDS. THIS GRANT FUNDS THE SECOND PHASE, WHICH CONSISTS OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH LOVELAND, COLORADO.

STEM

TRADE ADJUSTMENT ASSISTANCE COMMUNITY COLLEGE AND CAREER TRAINING

CITY OF LOVELAND TRANSIT SECTION 5307 CARES ACT - OPERATING AND CAPITAL

NEUROIMMUNE INTERACTIONS, LOW-DOSE SARIN INHALATION, AND GULF WAR SYNDROME

INCREASED SURVIVAL RATE FOLLOWING HEMORRAGHIC SHOCK AND TRAUMATIC BRAIN INJURY IN AUSTERE ENVIRONMENTS

SMALLER LEARNING COMMUNITIES (OESE)

NEW AWARD OBLIGATING $393,070. SEE TERMS AND CONDITIONS AND SOO BELOW. - WEST BANK

AFFORDABLE CARE ACT - CAPITAL DEVELOPMENT GRANTS

APPLICATION PURPOSE: ENSURE COLTS ABILITY TO PROVIDE RELIABLE PUBLIC TRANSIT SERVICE THROUGH REPLACEMENT VEHICLES.; ACTIVITIES PERFORMED: PURCHASE THREE REPLACEMENT BUSES INCLUDING 1 CNG AND 2 DIESEL HYBRID BUSES.; EXPECTED OUTCOMES: THE NEW BUSES WILL IMPROVE EFFICIENCY AIR QUALITY AND REDUCE CONGESTION.; INTENDED BENEFICIARIES: TRANSIT USERS AND COMMUTERS USING COLT.; SUBRECIPIENT ACTIVITIES: N/A

DEPOSITION PROFILE AND TOXICOLOGY OF E-CIGARETTES IN THE ORAL EPITHELIUM

APPLICATION PURPOSE: THE PURPOSE OF THIS GRANT IS TO USE FY21 APRA FUNDS FOR THE CONSTRUCTION OF PHASE 1 OF THE COLT NORTH TRANSIT CENTER.; ACTIVITIES PERFORMED: CAPITAL - CONSTRUCTION OF PHASE 1 OF THE NORTH TRANSIT CENTER. PHASE 1 CONSISTS OF ALL GROUNDWORK UTILITIES BUS LANE PASSENGER PLATFORM AND PARKING AREA OF THE TRANSIT CENTER SITE.; EXPECTED OUTCOMES: THIS GRANT WILL PROVIDE FUNDING TO CONTINUE THE PROGRESS OF COMPLETING THE CONSTRUCTION OF A TRANSIT CENTER. THE FACILITY WILL BE THE FIRST MAJOR INFRASTRUCTURE IN THE LOVELAND TRANSIT SYSTEM PROVIDING A LONG-TERM SOLUTION WHILE ACCOMMODATING ADDITIONAL RIDERS CUSTOMER PARKING AND LARGER BUSES. IN ADDITION THE NEW FACILITY WILL DRAW ADDITIONAL USERS ALLOW FOR EASIER ACCESS MITIGATE TRAFFIC CONCERNS ENHANCE PEDESTRIAN SAFETY AND PROVIDE SHELTER. THIS FACILITY WILL SUPPORT GROWTH IN THE LOCAL AND REGIONAL SERVICES AS WELL AS REDEVELOPMENT ALONG THIS SEGMENT OF THE US 287 CORRIDOR.; INTENDED BENEFICIARIES: PASSENGERS AND BUS OPERATORS OF BOTH CITY OF LOVELAND TRANSIT (COLT) AND TRANSFORT REGIONAL ROUTE AS WELL AS THE GENERAL PUBLIC CHOOSING TO USE THE PARK RIDE AREA.; SUBRECIPIENT ACTIVITIES: THERE ARE NO SUB-RECIPIENT ACTIVITIES ASSOCIATED WITH THIS AWARD.

COGNITIVE SEQUELAE OF CEREBROVASCULAR AND GUT DYSFUNCTION IN POST-ACUTE COVID-19 SYNDROME. - ABSTRACT: APPROXIMATELY ONE THIRD OF NON-HOSPITALIZED CORONAVIRUS DISEASE OF 2019 (COVID-19) PATIENTS REPORT CHRONIC SYMPTOMS AFTER RECOVERING FROM THE ACUTE STAGE OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2) INFECTION. SOME OF THE MOST PERSISTENT AND COMMON COMPLAINTS OF THIS POST-ACUTE COVID-19 SYNDROME (PACS) ARE COGNITIVE IN NATURE, DESCRIBED SUBJECTIVELY AS “BRAIN FOG” AND ALSO OBJECTIVELY MEASURED AS DEFICITS IN EXECUTIVE FUNCTION, WORKING MEMORY, ATTENTION, PROCESSING SPEED. THE MECHANISMS OF THESE CHRONIC COGNITIVE SEQUELAE ARE CURRENTLY NOT UNDERSTOOD. MOST STUDIES TO-DATE HAVE FOCUSED ON DIRECT SARS-COV-2 INFECTION OF THE BRAIN; HOWEVER, WHILE DIRECT VIRAL BRAIN INFECTION IS PLAUSIBLE IN ACUTE CASES OF SEVERE AND FATAL COVID-19, IT IS OF INTEREST TO EXAMINE INDIRECT MECHANISMS OF CHRONIC COGNITIVE DYSFUNCTION THAT FOLLOW MILD AND ASYMPTOMATIC DISEASE CASES. SARS-COV-2 INFLICTS DAMAGE TO CEREBRAL BLOOD VESSELS AND THE INTESTINAL WALL BY BINDING TO ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) RECEPTORS AND ALSO BY PRODUCING HIGH LEVELS OF SYSTEMIC CYTOKINES, COMPROMISING THE BRAIN’S NEUROVASCULAR UNIT AND DEGRADING THE INTESTINAL BARRIER, POTENTIALLY INCREASING THE PERMEABILITY OF BOTH TO HARMFUL SUBSTANCES. SUCH SUBSTANCES ARE HYPOTHESIZED TO BE PRODUCED BY PATHOGENIC MICROBIOTA IN THE GUT THAT, GIVEN THE PROFOUND EFFECTS COVID-19 HAS ON THE GASTROINTESTINAL SYSTEM, MAY FLOURISH VIA INTESTINAL DYSBIOSIS. COVID-19 MAY THEREFORE CREATE A SCENARIO IN WHICH NEUROTOXIC AND NEUROINFLAMMATORY SUBSTANCES READILY PROLIFERATE FROM THE GUT LUMEN AND ENCOUNTER A WEAKENED NEUROVASCULAR UNIT, GAINING ACCESS TO THE BRAIN AND SUBSEQUENTLY PRODUCING COGNITIVE DEFICITS. WE INTEND TO EXAMINE SUCH EFFECTS OF SARS-COV-2 IN PACS PATIENTS LONGITUDINALLY OVER THE COURSE OF 3 STUDY VISITS (BASELINE, 4 MONTHS, AND 8 MONTHS). THE IMPAIRMENTS OF CEREBROVASCULAR FUNCTION AND INTESTINAL BARRIER, AS WELL AS THEIR EFFECTS ON COGNITIVE SYMPTOMOLOGY, WILL BE EXAMINED IN 80 FORMER COVID-19 PATIENTS WHO RECOVERED FROM NON-HOSPITALIZED ACUTE PHASES OF COVID-19, YET REPORT PERSISTENT COGNITIVE SYMPTOMS (PACS+). THESE PATIENTS WILL BE COMPARED WITH 80 FORMER SIMILAR COVID-19 PATIENTS WITHOUT SUCH SYMPTOMS (PACS-). FORTY HEALTHY CONTROL PARTICIPANTS WILL ALSO BE RECRUITED TO ESTABLISH GENERAL NEUROVASCULAR, INTESTINAL, AND COGNITIVE EFFECTS OF COVID-19 HISTORY. CEREBROVASCULAR FUNCTION WILL BE QUANTIFIED VIA INNOVATIVE FUNCTIONAL MAGNETIC RESONANCE IMAGING OF CEREBROVASCULAR REACTIVITY (CVR) TO RESPIRATION OF CO2 GAS, WHILE THE INTESTINAL BARRIER WILL BE ASSESSED VIA CONCENTRATIONS OF INTESTINAL WALL BIOMARKERS IN BLOOD PLASMA SUCH AS FATTY ACID-BINDING PROTEIN 2 (FABP-2) AND ZONULIN. GUT DYSBIOSIS WILL BE ESTABLISHED VIA LACTULOSE BREATH TESTING, AND LEVELS OF SUBSEQUENTLY PRODUCED AND SYSTEMICALLY RELEASED LIPOPOLYSACCHARIDE (LPS), PEPTIDOGLYCAN (PGN) AND PRO-INFLAMMATORY CYTOKINES WILL ALSO BE QUANTIFIED. IMPAIRMENTS IN THE NEUROVASCULAR UNIT AND INTESTINAL BARRIER IN THE CONTEXT OF GUT DYSBIOSIS ARE EXPECTED TO BE ASSOCIATED WITH GREATER COGNITIVE DEFICITS IN PACS+ PATIENTS. THIS WORK MAY REVEAL IMMEDIATE RECOURSES FOR RESOLVING PACS COGNITIVE EFFECTS VIA EXISTING TREATMENTS FOR VASCULAR DYSFUNCTION AND GUT HEALTH.

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

BRIDGING INFLAMMATION AND CIGARETTE SMOKE-ASSOCIATED LUNG CARCINOGENESIS BY MUC1

CONVENTIONAL WEAPONS DESTRUCTION IN KYRGYZ REPUBLIC

LJI WILL IMPLEMENT A NEW APPROACH TO OBSERVE AND DIRECT ACTION TO HALT TRAFFICKING IN PROGRESS, IDENTIFY PERPETRATORS, AND GAIN INTELLIGENCE.

LETHAL H5N1 VIRUS INFECTION AND RESPIRATORY DISORDERS

HOMELESS PREVENTION

IMPROVE EXISTING AIRPORT

WASH AND SHELTER INTERVENTIONS FOR IDPS AND RETURNEES

THIS AWARD APPROVES THE 2026-2027 VOLUNTEER GENERATION FUND PROGRAM DESCRIBED IN THE APPROVED PROGRAM NARRATIVE AND BUDGET. YOUR 2026-2027 REGULATORY MATCH IS 20% AND YOUR BUDGETARY MATCH IS 20.43%.

NEW AWARD FOR $2,000,000 IN LEBANON FOR CWD ACTIVITIES. PLEASE SEE AWARD PROVISIONS AND ATTACHMENTS BELOW.

NEW AWARD OBLIGATING $2,000,000. SEE TERMS AND CONDITIONS AND SOO BELOW. - LEBANON

WORLD LANGUAGE WLARP ADVANCEMENT AND READINESS PROGRAM (WLARP)

MILITARY-CONNECTED LOCAL EDUCATION AGENCIES FOR ACADEMIC AND SUPPORT PROGRAMS (MCASP)

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - FOR THE PURPOSE OF HRSA-23-117, TLC PROPOSES REPLACING THE ROOF OF THE MAIN, 250,000 SQUARE FOOT FACILITY AND UPGRADING THE FLOORS, DRYWALL, PAINT, ELECTRICAL, AND LIGHTING FOR TWO TLC DORMS: THE SUPERVISED RE-ENTRY PROGRAM (SRP) DORM AND THE INFIRMARY DORM. WE ANTICIPATE COMPLETING RENOVATIONS WITHIN 36 MONTHS AFTER WORK BEGINS. THE TLC ROOF REPLACEMENT, AND SRP/INFIRMARY DORMS RENOVATION PROJECT COSTS $2,214,703. THIS COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING (CPF/CDS) APPLICATION REQUESTS $2,000,000 TO COVER A PORTION OF THE ROOFING AND RENOVATION COSTS. TLC WILL UTILIZE PRIVATE CONTRIBUTIONS AND POTENTIALLY ADDITIONAL GRANT FUNDING TO COVER THE BALANCE OF PROJECT COSTS. MODIFICATIONS AND/OR REPAIRS TO THE BUILDING EXTERIOR (INCLUDING WINDOWS): THIS PROJECT INVOLVES DEMOLITION AND REMOVAL OF ALL LAYERS OF EXISTING ROOFING MATERIALS AND THEN REMOVING THIS DEBRIS FROM THE JOBSITE. ALSO INCLUDED ARE REPAIRS, AND IN SOME CASES REPLACEMENT OF FAILED WOOD, METAL, AND CONCRETE ROOF DECKING. THE PROJECT WILL INCLUDE INSTALLING INSULATION, A CUSHION FOR THE DECKING, NEW DURO-LAST PVC MEMBRANES OVER THE INSULATION AND PARAPET WALLS, AND NEW FLASHINGS. IMPROVEMENT AND/OR RECONFIGURATION OF THE INTERIOR ARRANGEMENTS OF THE EXISTING FACILITY: TLC PLANS TO RENOVATE TWO KEY DORM AREAS THAT HOUSE WOMEN IN CARE - THE SUPERVISED RE-ENTRY PROGRAM (SRP) DORM AND THE INFIRMARY DORM. BOTH SPACES CURRENTLY ARE OUTDATED AND UNSAFE WITH CRACKED, PEELING FLOORING, CHIPPED PAINT, WATER-STAINED DROP-CEILING TILES, OUTDATED LIGHT FIXTURES, AND UNHYGIENIC SURFACES. THESE SPACES ARE OBSERVABLY UNHEALTHY AND VISUALLY CHAOTIC AND UNAPPEALING. RENOVATION GOALS INCLUDE: DEMOLITION OF CEILINGS AND OTHER FAILED SURFACES, WALL AND FLOOR PREP, AND REMOVAL OF OLD LIGHT FIXTURES AND WINDOW TREATMENTS. REFURBISHMENT WILL INVOLVE INSTALLATION OF NEW ANTI-MICROBIAL, VINYL ENGINEERED FLOORING, FRESH, GERM-RESISTANT PAINT, NEW CHILD-PROOF WINDOW BLINDS, AND NEW SUSP ENDED CEILINGS IN SOME AREAS. THESE CEILING UPGRADES WILL PROVIDE A COST-EFFECTIVE, STYLISH REPLACEMENT OF THE CURRENT INSTITUTIONAL DROP-CEILING TILES. FROM A HEALTH AND WELLNESS PERSPECTIVE, THESE MITIGATIONS WILL IMPEDE THE GROWTH OF A BROAD SPECTRUM OF BACTERIA, FUNGI, YEAST, AND MILDEW. VISUALLY, THEY WILL REDUCE THE SOMEWHAT INSTITUTIONAL FEEL OF CURRENT SPACES AND PROVIDE TLC CLIENTS WITH A HOME SPACE THEY CAN FEEL PRIDE IN, WHICH RESEARCH SHOWS ENHANCES RECOVERY

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

MECHANISM AND COUNTERMEASURE OF CARFENTANIL-INDUCED RESPIRATORY DISORDER AND DEATH - PROJECT SUMMARY OPIOIDS WERE INVOLVED IN 75,673 OVERDOSE DEATHS IN 2020 IN THE U.S, IN WHICH FENTANYL, A SYNTHETIC OPIOID, IS THE DEADLIEST DUE TO INDUCTION OF VENTILATORY DEPRESSION. CARFENTANIL (CFN) IS ANOTHER SYNTHETIC OPIOID ACTING ON OPIOID MU-RECEPTORS (MORS) WITH A POTENCY 100 TIMES THAT OF FENTANYL. THOUGH NO INTENDING FOR THERAPEUTIC USE, AEROSOLIZED CFN HAS BEEN APPLIED AS A LETHAL AGENT (BIOWEAPON) TO CAUSE RESPIRATORY DISORDER (RD) AND DEATH IN HUMANS. NALOXONE INCREASES SURVIVAL RATE OF OVERDOSE OPIOIDS IN EARLY REPORTS; HOWEVER, DEATHS HAVE BEEN INCREASING AFTER SYNTHETIC OPIOID ERA DUE TO UNSUCCESSFUL RESUSCITATION ATTEMPTS IN CLINICAL SETTINGS. IT ALSO FAILS TO REVERSE AEROSOLIZED CFN-INDUCED RD/DEATH IN ANIMALS. TO DATE, THE CHARACTERISTICS, MECHANISMS, AND EFFECTIVE COUNTERMEASURE OF ACUTE CFN EXPOSURE-INDUCED RD/DEATH ARE STILL UNCLEAR. OVERDOSE FENTANYL VIA INTRAVENOUS (IV) PERFUSION PRODUCES RD INCLUDING GRADUAL VENTILATORY DEPRESSION (DVE) AND THEN APNEAS/GASPING BEFORE DEATH. THE RD IS BELIEVED TO RESULT FROM INHIBITING THE CAROTID BODY O2-RECEPTOR AND CENTRAL CO2-CHEMORECEPTORS, ESPECIALLY THOSE IN THE RETROTRAPEZOID AND PARAFACIAL NUCLEUS (RTN/PFN) AND THE RESPIRATORY NEURONS IN THE PRE-BÖTZINGER COMPLEX (PBC, THE RESPIRATORY RHYTHM-GENERATOR). INTERESTINGLY, WE RECENTLY REPORTED THAT IV BOLUS INJECTION OF FENTANYL INDUCED AN IMMEDIATE APNEA SOLELY MEDIATED BY BRONCHOPULMONARY C-FIBERS (PCFS) IN ANESTHETIZED RATS. OUR PILOT STUDY FURTHER SHOWS THAT THE APNEA IS ASSOCIATED WITH CLOSURE OF THE LARYNX, CONSTRICTION OF CHEST EXPIRATORY MUSCLES, AND SILENCE OF INSPIRATORY MUSCLES (I.E., OBSTRUCTIVE AND CENTRAL APNEA WITH CHEST WALL RIGIDITY), WHICH IS LETHAL IF OVERDOSED. MOREOVER, AEROSOLIZED FENTANYL (100 MG/M3 FOR 10 MIN) INITIALLY TRIGGERS THE SIMILAR APNEA FOLLOWED BY DVE AND GASPING, LEADING TO DEATH ~10 MIN POST EXPOSURE IN ANESTHETIZED RATS. IN THIS PROPOSAL, WE, THEREFORE, WILL CHARACTERIZE THE CARDIORESPIRATORY (RESPIRATORY MUSCLES’) RESPONSES TO ACUTE CFN EXPOSURE IN AWAKE RATS AND DETERMINE THE CAUSAL ROLES OF PERIPHERAL AND CENTRAL MORS (AIM 1). SUBSEQUENTLY, WE WILL MECHANISTICALLY DEMONSTRATE THAT CFN EXPOSURE STIMULATES PCFS TO TRIGGER THE INITIAL APNEAS AND THEN INHIBITS THE CAROTID BODY, RTN/PFN CO2-SENSITIVE AND PBC RESPIRATORY NEURONS TO PRODUCE DVE AND GASPING (APNEAS) BY ACTING ON LOCAL MORS (AIM 2). DOXAPRAM IS A POTENT RESPIRATORY STIMULANT TO THE CAROTID BODY, WHILE CX717 CAN ENHANCE RESPIRATORY FREQUENCY AND RESPIRATORY DRIVE VIA ACTING ON THE PBC AND STRENGTHEN CENTRAL CO2-CHEMORECEPTION. BOTH AGENTS ARE CAPABLE OF REVERSING OPIOID-INDUCED RD IN ANIMALS AND HUMANS. THIS, ALONG WITH MOR INTERNALIZATION IN VAGAL SENSORY NEURONS AND BLOCKADE OF IV INJECTION OF FENTANYL-INDUCED APNEA BY DERMORPHIN PRETREATMENT (A PERIPHERALLY ACTING MOR AGONIST, IV) IN OUR PILOT STUDY, ALLOWS US TO DEFINE IF A COCKTAIL PRETREATMENT OF DERMORPHIN, DOXAPRAM, AND CX717 IS A COUNTERMEASURE FOR CFN-INDUCED RD/DEATH (AIM 3). A MULTIDISCIPLINARY APPROACH (ELECTROPHYSIOLOGY, IMMUNOHISTOCHEMISTRY, AND PHARMACOLOGY) AT SYSTEMIC AND CELLULAR LEVELS WILL BE EMPLOYED TO ELUCIDATE THE MECHANISMS UNDERLYING ACUTE CFN EXPOSURE-INDUCED RD/DEATH AND EVALUATE THE EFFICACY OF THE COCKTAIL PRETREATMENT. THE EXPECTED DATA WILL, FOR THE FIRST TIME, MECHANISTICALLY REVEAL THE KEY ROLES OF PCFS, THE CAROTID BODY, RTN/PFN AND PBC IN GENERATING THE CFN-INDUCED RD AND PROVIDE A NOVEL AND POTENTIAL COUNTERMEASURE TO PREVENT/DIMINISH THE RD/DEATH.

ASSESSING TOXICANT PROPERTIES AND HEALTH EFFECTS OF CIGARILLO AND HOOKAH TOBACCO AEROSOLS IN RATS

A UNIFIED FRAMEWORK FOR FLEXIBLE BRAIN IMAGE ANALYSIS

NEW AWARD OBLIGATING $1,000,000.00 IN NADR-CWD BILAT CROATIA FUNDS. TERMS AND CONDITIONS BELOW.

VOICELOVE: NICU UTILIZATION OF REMOTE VOICE TECHNOLOGY TO IMPROVE MATERNAL EXPERIENCE (NURTURE) - POSTPARTUM DEPRESSION (PPD) IS THE MOST FREQUENT MAJOR DEPRESSIVE DISORDER FOLLOWING CHILDBIRTH AND IS ASSOCIATED WITH ADVERSE OUTCOMES AND POOR QUALITY OF LIFE FOR THE MOTHER AND CHILD. SEPARATION DURING THE INITIAL POSTPARTUM PERIOD, SUCH AS INFANT ADMISSION TO THE NEONATAL INTENSIVE CARE UNIT (NICU), IMPACTS MATERNAL- INFANT BONDING AND INCREASES PPD RISK BY 40%. FEELING DISCONNECTED FROM THEIR INFANT IS A MAJOR RISK FACTOR FOR NICU PARENTS DEVELOPING PPD. THE SENSE OF PARENTS NOT FEELING CONSTANTLY CONNECTED TO THEIR INFANTS DURING A NICU STAY, AND LOW SOCIAL SUPPORT CREATE A HIGH EMOTIONAL BURDEN ON THE MOTHER AND HER PARTNER. PPD RISK IS DECREASED WHEN PARENTS HAVE MORE CONTACT WITH THEIR INFANT AND A HIGHER PERCEIVED SOCIAL SUPPORT SYSTEM. WHEN PHYSICAL CONTACT IS NOT POSSIBLE, VOICE CONTACT MAY HELP TO FOSTER FEELINGS OF CONNECTEDNESS. THE MEDICAL TEAM IS ANOTHER CRITICAL SOURCE OF SOCIAL SUPPORT THAT CAN ALTER PARENTAL MENTAL HEALTH. MOTHERS OF INFANTS IN THE NICU REPORT INCREASED DEPRESSIVE SYMPTOMS WHEN THEIR PERCEPTION OF NURSE SUPPORT IS LOW, WHILE INCREASED COMMUNICATION BETWEEN PARENTS AND THE MEDICAL TEAM IMPROVES PARENTAL WELL- BEING. INCREASED SOCIAL SUPPORT FROM LOVED ONES AND THE MEDICAL CARE TEAM COULD SIGNIFICANTLY REDUCE PPD SEVERITY IN PARENTS OF BABIES IN THE NICU. HOWEVER, NICU UNITS ARE PRIMARILY FOCUSED ON INFANT CARE AND ARE ILL- EQUIPPED TO ADDRESS PARENTAL MENTAL HEALTH. FACILITATING COMMUNICATION BETWEEN PARENTS AND HEALTHCARE PROVIDERS, AS WELL AS BETWEEN THEIR FRIENDS AND FAMILY, WITHOUT INCREASING WORK BURDEN FOR HEALTHCARE PROVIDERS COULD DRAMATICALLY IMPACT THE MENTAL HEALTH AND WELL-BEING OF PARENTS DURING THEIR BABY’S NICU ADMISSION. VOICELOVE LLC IS DEVELOPING A NOVEL HIPAA-COMPLIANT MOBILE APPLICATION THAT ENABLES EXPANDED FAMILY ENGAGEMENT BY PROVIDING AN ELECTRONIC VENUE FOR DIRECT PATIENT-FAMILY-PROVIDER INTERACTIONS THAT MITIGATES BARRIERS TO COMMUNICATION. THE VOICELOVE APP IS A SAFE AND TIME-EFFICIENT TOOL FOR DIRECT COMMUNICATION WITH ABSENT FAMILY MEMBERS, ALLOWING MORE TIME FOR DIRECT PATIENT CARE. A PILOT STUDY WITH ICU PATIENTS AT NEW YORK- PRESBYTERIAN HOSPITAL DEMONSTRATED THOUSANDS OF DIRECT FAMILY MESSAGES EXCHANGED WITHOUT ANY ADDITIONAL NURSING BURDEN. IN THIS FAST-TRACK STTR, WE WILL REFINE THE VOICELOVE PROTOTYPE AND EVALUATE THE NEW APPLICATION AMONG PARENTS AND NICU PROVIDERS. PHASE I WILL OPTIMIZE THE VOICELOVE APP FOR NICU FAMILIES AND PROVIDERS. PHASE II WILL INCLUDE A RANDOMIZED CONTROL TRIAL (RCT) COMPARING VOICELOVE IMPLEMENTATION TO USUAL CARE CONTROL TO EVALUATE THE IMPACT OF THE VOICELOVE APP ON MATERNAL PPD SCORES AND ON PATIENT-FAMILY- PROVIDER COMMUNICATION AND ENGAGEMENT. THIS FAST-TRACK STTR REPRESENTS A MAJOR STEP FORWARD IN BRINGING A NOVEL TECHNOLOGY TO THE NICU TO EXPAND FAMILY ENGAGEMENT, EMPOWER THE CLINICAL EXPERIENCE, AND DECREASE THE PREVALENCE OF PPD.

TUMOR SUPPRESSOR GENE METHYLATION IN LUNG ADENOCARCINOMA

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

ASSESSING TOXICANT PROPERTIES OF CIGARILLO AND HOOKAH AEROSOLS IN LUNG EPITHELIAL AND CARDIAC CELLS THROUGH AEROSOL EXPOSURE

LANDMINE CLEARANCE AND BATTLE AREA CLEARANCE ACTIVITIES IN SERBIA

VOICELOVE: AN APP-BASED COMMUNICATION TOOL DESIGNED TO ADDRESS DELIRIUM AND IMPROVE FAMILY ENGAGEMENT AND PATIENT/FAMILY SATISFACTION IN CRITICALLY ILL PATIENTS (COMMUNICATE) - ICU DELIRIUM IS A DEVASTATING COMPLICATION OF ILLNESS, ACUTE TRAUMA, AND SURGERY OFTEN RESULTING IN PROLONGED MECHANICAL VENTILATION, LONGER LENGTHS OF STAY, AND LONG-TERM DISABILITY. DELIRIUM IS ASSOCIATED WITH OVER 12 TIMES INCREASED ODDS OF DEVELOPING ALZHEIMER’S DISEASE (AD) AND AD-RELATED DEMENTIAS (ADRD). IN ADDITION, DELIRIUM ACCELERATES COGNITIVE DECLINE IN AD/ADRD PATIENTS. LIKEWISE, PATIENTS WITH UNDERLYING DEMENTIA ARE 2.5-4.7 TIMES MORE LIKELY TO DEVELOP DELIRIUM. AD/ADRD PATIENTS WHO DEVELOP DELIRIUM HAVE A MARKED INCREASE IN ADVERSE OUTCOMES INCLUDING RATE OF COGNITIVE DECLINE, INSTITUTIONALIZATION, AND DEATH FOLLOWING AN EPISODE OF DELIRIUM COMPARED TO THOSE WITHOUT PRE-EXISTING AD/ADRD. THE ABCDEF (A2F) BUNDLE HAS THE BEST SUCCESS AT DECREASING ICU DELIRIUM AMONG PHARMACOLOGIC AND NONPHARMACOLOGIC INTERVENTIONS. THE A2F BUNDLE IS A GROUP OF EVIDENCE-BASED ASSESSMENTS AND INTERVENTIONS (I.E., ASSESS, PREVENT, AND MANAGE PAIN, BOTH SPONTANEOUS AWAKENING AND BREATHING TRIALS, CHOICE OF ANALGESIA AND SEDATION, DELIRIUM: ASSESS, PREVENT, AND MANAGE, EARLY MOBILITY AND EXERCISE, AND FAMILY ENGAGEMENT AND EMPOWERMENT) DESIGNED TO IMPROVE ICU PATIENT CARE REGARDLESS OF ILLNESS PATHOLOGY. FAMILY ENGAGEMENT, AN A2F BUNDLE COMPONENT INDEPENDENTLY ASSOCIATED WITH REDUCED ICU DELIRIUM PREVALENCE, WAS IMPLEMENTED IN 63% OF ICUS PRE-PANDEMIC AND DROPPED TO UNDER 20% DURING THE PANDEMIC. AS THE PANDEMIC RESOLVES, THERE IS A GRADUAL RETURN TO NORMAL VISITATION POLICIES, BUT, OVERALL, FAMILIES REMAIN UNDER ENGAGED. INTERVENTIONS THAT EXPAND FAMILY ENGAGEMENT HAVE THE POTENTIAL TO SIGNIFICANTLY IMPROVE SHORT- AND LONG-TERM PATIENT (E.G., AD/ADRD, DISABILITY) AND FAMILY OUTCOMES. VOICELOVE LLC IS DEVELOPING A NOVEL HIPAA-COMPLIANT MOBILE APPLICATION THAT ENABLES EXPANDED FAMILY ENGAGEMENT BY MITIGATING MULTIFACTORIAL BARRIERS KNOWN TO INFLUENCE A2F BUNDLE IMPLEMENTATION. THE VOICELOVE APP IS A SAFE AND TIME- EFFICIENT TOOL ALLOWING DIRECT COMMUNICATION BETWEEN PATIENTS AND THEIR FAMILY MEMBERS, AND BETWEEN CARE PROVIDERS AND ABSENT FAMILY MEMBERS, ALLOWING MORE TIME FOR DIRECT PATIENT CARE. A PILOT STUDY WITH ICU PATIENTS AT NEW YORK-PRESBYTERIAN HOSPITAL DEMONSTRATED THOUSANDS OF DIRECT FAMILY MESSAGES EXCHANGED WITHOUT ANY ADDITIONAL NURSING BURDEN. IN THIS FAST-TRACK STTR, WE WILL REFINE THE VOICELOVE PROTOTYPE AND EVALUATE THE NEW APPLICATION AMONG MECHANICALLY VENTILATED ADULT PATIENTS ADMITTED TO A MEDICAL, SURGICAL, OR CORONARY ICU. PHASE I WILL OPTIMIZE THE VOICELOVE APP FOR ICU PATIENTS, FAMILIES, AND PROVIDERS. PHASE II WILL INCLUDE A RANDOMIZED CONTROL TRIAL (RCT) COMPARING VOICELOVE IMPLEMENTATION TO USUAL CARE CONTROL TO INVESTIGATE THE EFFECT ON OPTIMIZING PATIENT-FAMILY-PROVIDER COMMUNICATION, ENGAGEMENT, AND ICU DELIRIUM PREVALENCE. MITIGATING ICU DELIRIUM IS OF PARAMOUNT IMPORTANCE TO REDUCING THE RISK OF LONG-TERM COMPLICATIONS, INCLUDING AN INCREASED RISK OF DEVELOPING AD/ADRD AS WELL AS ACCELERATING DECLINE IN PATIENTS WITH AD/ADRD. THIS FAST-TRACK STTR REPRESENTS A MAJOR STEP FORWARD IN BRINGING A NOVEL TECHNOLOGY TO THE BEDSIDE TO EXPAND FAMILY ENGAGEMENT AND EMPOWERMENT, DECREASE THE PREVALENCE OF ICU DELIRIUM, AND THUS REDUCE LONG-TERM AD/ADRD RISK.

COMMUNITY CONNECT GRANT

ERROR DETECTION AND ERROR AWARENESS IN INCARCERATED COCAINE DEPENDENT INDIVIDUALS

COMMON CORE STANDARDS MATH AND SCIENCE - STEM

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

MULTIMODAL PREDICTION OF BEHAVIORAL AND MENTAL HEALTH OUTCOMES IN INCARCERATED WOMEN - PROJECT SUMMARY/ABSTRACT RESEARCH IN PSYCHOLOGY AND NEUROSCIENCE HAS HELPED DEEPEN OUR UNDERSTANDING OF RELATIONSHIPS BETWEEN MENTAL HEALTH ISSUES, SOCIAL-ENVIRONMENTAL FACTORS, AND MALADAPTIVE BEHAVIORS CONTRIBUTING TO RISK FOR INCARCERATION. SUCH RESEARCH HOLDS SIGNIFICANT ECONOMIC IMPLICATIONS, AS THE SOCIETAL COST OF CRIME IN THE UNITED STATES IS A STAGGERING $3.2 TRILLION ANNUALLY, A SUM THAT EXCEEDS ANNUAL EXPENDITURES ACROSS ALL NATIONAL HEALTH CARE. WHILE MOST OF THESE COSTS ARE DUE TO MEN, INCARCERATED WOMEN REPRESENT THE SINGLE FASTEST GROWING SEGMENT OF THE CRIMINAL LEGAL POPULATION OVER RECENT DECADES. RELATIVE TO MEN, WOMEN IN THE LEGAL SYSTEM DISPLAY HIGHER RATES OF MENTAL HEALTH PROBLEMS, INCLUDING WITH COMORBID SUBSTANCE USE, THOSE OF WHICH RESULT IN A MULTITUDE OF NEGATIVE OUTCOMES THAT IMPACT WOMEN AND THEIR OVERALL PSYCHOSOCIAL FUNCTIONING, AS WELL AS SOCIAL NETWORKS AND PUBLIC HEALTH SYSTEMS, BROADLY. DESPITE THIS, THERE HAS BEEN LITTLE MODERN RESEARCH DEDICATED TO FEMALE FORENSIC POPULATIONS. INDEED, WE NEED PROSPECTIVE WORK IN FORENSIC SAMPLES OF WOMEN AIMED AT UNDERSTANDING ADAPTIVE AND MALADAPTIVE CHANGES IN MENTAL HEALTH FUNCTIONING OVER TIME, INCLUDING RISK AND PROTECTIVE FACTORS THAT INFLUENCE THESE CHANGES. THIS TYPE OF WORK IS FAR REACHING, AS IT CAN BE TRANSLATED TO TREATMENT OPTIONS TO PROVIDE BETTER LONG-RANGE OUTCOMES FOR THIS POPULATION. IN PRIOR NIH-SUPPORTED WORK, WE HAVE EXAMINED PSYCHOSOCIAL AND BRAIN FUNCTIONING IN 588 INCARCERATED WOMEN AND FEMALE YOUTH. HERE WE PROPOSE TO UTILIZE THIS SAMPLE TO CREATE A UNIQUE LONGITUDINAL STUDY IN ORDER TO DEVELOP ALGORITHMS THAT HELP PREDICT MENTAL HEALTH FUNCTIONING AND RELATED OUTCOMES (E.G., RECIDIVISM, SUBSTANCE USE RELAPSE). OUR ALGORITHMS WILL UTILIZE THE LATEST IN MACHINE LEARNING TECHNIQUES AND WILL INCLUDE MULTIMODAL (PSYCHOSOCIAL, FORENSIC, AND NEUROIMAGING) VARIABLES. UTILIZING THESE METHODS, WE INTEND TO IDENTIFY SPECIFIC BRAIN MEASURES, IN COMBINATION WITH PSYCHOSOCIAL AND FORENSIC VARIABLES, THAT ACCOMPANY LONG-RANGE OUTCOMES OF RESILIENCE (DESISTANCE) AND RISK (POOR GLOBAL MENTAL HEALTH, RECIDIVISM, SUBSTANCE USE RELAPSE). THE TRANSLATIONAL VALUE OF THIS WORK WILL BE TO CLARIFY INFORMATIVE PATTERNS OF DATA THAT MAY INDICATE POSITIVE OUTCOMES. FURTHERMORE, NEURAL MEASURES INDICATIVE OF SPECIFIC VULNERABILITY WILL BE IDENTIFIED AS TARGETS FOR TREATMENT AND NOVEL INTERVENTION STRATEGIES. BY IDENTIFYING VULNERABILITIES AND THE CHANGES THAT ACCOMPANY POSITIVE OUTCOMES, WE WILL BE CLOSER TO UNDERSTANDING WAYS TO IMPROVE OUTCOMES FOR VULNERABLE WOMEN.

EFFECT OF PRENATAL NICOTINIC EXPOSURE ON CONTROL OF HYPOXIC VENTILATORY RESPONSE

PURPOSE: EXTEND/EXPAND RUNWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT EXPANDS RUNWAY 15/33 AN ADDITIONAL 50 FEET IN WIDTH TO BRING THE AIRPORT INTO CONFORMITY WITH CURRENT STANDARDS. THIS GRANT FUNDS A PORTION OF THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION. THIS GRANT IS ASSOCIATED WITH AN AIRPORT IMPROVEMENT PROGRAM GRANT THAT FUNDS THE REMAINING ELIGIBLE PORTION OF THE PROJECT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH LOVELAND, COLORADO.

NEW AWARD OBLIGATING $1.500.000 FOR BIH MINE FREE SARAJEVO. PRE-AWARD AUTHORIZED FROM 4/1/19. SEE TERMS AND CONDITIONS BELOW

A NEW PHARMACOTHERAPY FOR ALCOHOL DEPENDENCE: OLANZAPINE

PEOPLE IN NEED FOOD AND AGRICULTURE ASSISTANCE IN SOUTH KIVU, DRC

SENSITIVITY TO INTRAVENOUS ETHANOL: GENETIC DETERMINANTS

BRAIN INJURY TREATMENT BY MODULATION OF HEMODYNAMICS WITH BLOOD SOLUBLE DRAG REDUCING MOLECULES

EVALUATION OF RESPIRATORS FOR ENGINEERED NANOPARTICLES

MATCHING TREATMENTS TO COGNITIVE DEFICITS IN OFFENDERS WITH SUBSTANCE USE DISORDERS - PROJECT SUMMARY/ABSTRACT PRIOR RESEARCH HAS IDENTIFIED TWO SUBTYPES OF ANTISOCIAL OFFENDERS, TYPIFIED BY DISTINCT DYSFUNCTIONAL COGNITIVE- EMOTION INTERACTIONS UNDERMINING SELF-REGULATION. ONE SUBTYPE IS CHARACTERIZED BY AN ATTENTION-BASED ABNORMALITY, WHICH IMPAIRS ADAPTIVE PROCESSING OF CONTEXTUAL INFORMATION, TANGENTIAL TO ONE’S PRIMARY FOCUS. THIS ABNORMALITY IS TYPIFIED BY OFFENDERS WITH HIGH LEVELS OF CALLOUS/UNEMOTIONAL TRAITS. A SECOND SUBTYPE IS CHARACTERIZED BY HYPER-REACTIONS TO PERSONALLY RELEVANT CUES, INTERFERING WITH EXECUTIVE FUNCTIONS THAT ARE OTHERWISE NEEDED TO REGULATE BEHAVIOR. THIS ABNORMALITY IS PREVALENT IN THOSE WITH HIGH EXTERNALIZING CHARACTERISTICS. OUR TEAM HAS DEVELOPED COGNITIVE SKILLS TRAINING THAT ADDRESSES EACH OF THESE SPECIFIC DEFICITS IN DISTINCT WAYS. THESE DISTINCT INTERVENTIONS ARE INTENDED TO ADDRESS MECHANISM-SPECIFIC COGNITIVE EMOTIONAL DYSFUNCTION, AS OPPOSED TO TREATING DISTINCT DYSFUNCTIONS WITH A UNIFORM APPROACH. UNDER AN R21, OUR PILOT WORK HAS SHOWN EVIDENCE OF IMPROVING OUTCOMES IN OFFENDERS BY MATCHING SPECIFIC DEFICITS WITH FOCUSED SKILLS TRAINING. HERE WE SEEK TO CONDUCT A WELL-POWERED, RANDOMIZED CLINICAL TRIAL TO DEMONSTRATE RELIABILITY AND GENERALIZABILITY OF THESE EFFECTS. WE EXPECT TO VERIFY PRIOR FINDINGS OF IMPROVED OUTCOMES BY MATCHING INDIVIDUAL DEFICITS WITH THE TARGETED INTERVENTIONS. WE WILL EXAMINE EFFECTS OF TREATMENT ON SPECIFIC COGNITIVE SKILLS (ASSESSED BY LABORATORY- BASED TESTS) AND REAL-WORLD BEHAVIORAL OUTCOMES INCLUDING SUBSTANCE USE BEHAVIORS, INSTITUTIONAL ADJUSTMENT, AND RECIDIVISM FOLLOWING RELEASE FROM PRISON. FURTHER, WE WILL EXAMINE ADVANCED NEUROIMAGING MEASURES TO ASSESS BRAIN CHANGES WITH TREATMENT. THIS WILL AID IN SPECIFYING POTENTIALLY DIFFERENT MECHANISMS OF TREATMENT SUCCESS IN EACH RESPECTIVE GROUP. THIS PROJECT ADDRESSES THE ONGOING NEED TO IMPROVE AND VALIDATE FOCUSED INTERVENTIONS THAT TARGET SPECIFIC DEFICITS, REPLACING LESS-EFFECTIVE ONE-SIZE-FITS-ALL APPROACHES.

HUMAN IMMUNODEFICIENCY VIRUS (HIV) PREVENTION PROJECTS FOR COMMUNITY-BASED ORGANI

PURPOSE: CONSTRUCT TERMINAL BUILDING. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A 20,000 SQUARE FOOT TERMINAL BUILDING TO MEET CURRENT BUILDING CODES AND AMERICANS WITH DISABILITIES ACT STANDARDS. THIS GRANT FUNDS THE FINAL PHASE, WHICH CONSISTS OF 2,000 SQUARE FEET OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH LOVELAND, COLORADO.

SARS CORONAVIRUS VIRULENCE FACTORS AND LUNG PATHOGENESIS

R3 MAT PSYCHOSOCIAL SERVICES

IMPROVE EXISTING AIRPORT

NEW AWARD TO FOR LAF EOD CAPACITY SUPPORT IN LEBANON. SEE SOO, AWARD PROVISIONS, AND DOS TERMS AND CONDITIONS BELOW. - LEBANON

RESPONSE TO INTERVENTION (RTI)/MULTI-TIERED SUPPORT SYSTEMS IN MATHEMATICS, ELA, AND SOCIO-EMOTIONAL BEHAVIOR

STEM

COMMUNITY IN MOTION: A STRATEGIC COLLABORATIVE PROJECT

NEW BEGINNINGS - PILLAR, A CERTIFIED COMMUNITY BEHAVIORAL HEALTH CENTER, IN PARTNERSHIP WITH BETHANY HOUSE, LAREDO HOUSING AUTHORITY AND THE CITY OF LAREDO HEALTH DEPARTMENT, PROPOSES THE IMPLEMENTATION OF PROJECT NEW BEGINNINGS WITH A POPULATION OF FOCUS OF ADULTS, FAMILIES AND YOUTH DIAGNOSED WITH A SERIOUS MENTAL ILLNESS, SERIOUS EMOTIONAL DISTURBANCE, OR CO-OCCURRING DISORDERS WHO ARE EXPERIENCING HOMELESSNESS, OR AT RISK OF IMMINENT HOMELESSNESS IN THE CATCHMENT AREA OF WEBB, JIM HOGG, AND ZAPATA COUNTIES IN THE LAREDO-MEXICO BORDER REGION. THE PURPOSE OF THE PROJECT IS TO SUPPORT THE EXPANSION OF LOCAL IMPLEMENTATION OF A COMMUNITY INFRASTRUCTURE THAT INTEGRATES BEHAVIORAL HEALTH TREATMENT, PEER SUPPORT, RECOVERY SUPPORT SERVICES, AND LINKAGES TO SUSTAINABLE PERMANENT HOUSING. THE PROPOSED UNDUPLICATED NUMBERS ARE A TOTAL OF 310 PARTICIPANTS: 50 YR1, 60 YR2, 70 YR3, 80 YR4, AND 50 YR5. THE RATE OF HOMELESSNESS IN THE AREA HAS BEEN GREATLY AFFECTED BY THIS RAPID POPULATION GROWTH AND THE PRESENCE OF SIGNIFICANT SOCIOECONOMIC DISPARITIES WITH A STAGGERING 163% INCREASE IN HOMELESS COUNTS, FROM 213 IN 2018 TO 397 IN 2022. THE SELECTED CULTURALLY APPROPRIATE EVIDENCE-BASED PRACTICES INCLUDE ASSERTIVE COMMUNITY TREATMENT, SEEKING SAFETY, AND COGNITIVE BEHAVIORAL THERAPY. THE PRINCIPAL GOALS OF THE PROJECT ARE: 1) STRENGTHEN AGENCY PARTNERSHIPS, INFRASTRUCTURE AND EXPAND SERVICE COMPENDIUM TO ENSURE EFFECTIVE PLANNING AND SERVICE DELIVERY TO THE PRIORITY POPULATION ON THE TEXAS/MEXICO BORDER; 2) INCREASE ACCESS TO, OR PLACEMENT IN, SUSTAINABLE PERMANENT HOUSING, TREATMENT, AND RECOVERY SUPPORT SERVICES, TO INCLUDE MEDICAID AND OTHER BENEFIT PROGRAMS TO 310 PERSONS/FAMILIES EXPERIENCING HOMELESSNESS; AND 3) IMPLEMENT A COMPREHENSIVE EVALUATION AND DATA COLLECTION PLAN TO ASSESS CLIENT-LEVEL OUTCOMES AND PROJECT PERFORMANCE MEASURES. STAFFING PLAN INCLUDES A PROJECT DIRECTOR, PROJECT COORDINATOR, 2 LICENSED PROFESSIONAL COUNSELORS, 1 RECOVERY PEER SUPPORT SPECIALIST, 2 PATIENT NAVIGATORS/CASE MANAGERS, AND EVALUATOR.

OVERSEAS ASSISTANCE

A MULTI-SECTORAL EMERGENCY RESPONSE TO PROVIDE WASH, SHELTER AND CASH ASSISTANCE FOR MOST VULNERABLE IDPS AND RETURNEE AND HOST COMMUNITIES IN BORENA ZONE OF OROMIYA REGION AND KONSO ZONE OF SNNPR, IN SOUTHERN ETHIOPIA

A PROSPECTIVE OBSERVATIONAL STUDY ON THERAPEUTIC AND ADVERSE EFFECTS OF MEDICAL CANNABIS FOR CHRONIC TRAUMATIC BRAIN INJURY

ASSISTANCE TO FIREFIGHTERS GRANT

DOD IMPACT AID SUPPLEMENTAL

NEW AWARD OBLIGATING $1,000,000 FOR WEAPONS STOCKPILE MANAGEMENT IN SERBIA FOR 24 MONTHS. AWARD PROVISIONS, SOO, AND BUDGET BELOW.

306C WWD NATIVE AMERICAN GRANTS - WASTE DISPOSAL

DEVELOPMENT OF A PERSONAL SAMPLER FOR NANOPARTICLES

T5000 DIAGNOSTIC SYSTEM IN FERRET MODEL OF INFLUENZA

NEW AWARD OBLIGATING $1,700,000. SEE TERMS AND CONDITIONS AND STATEMENT OF OBJECTIVES BELOW.

PROMOTING MATH AND SCIENCE

TO PROVIDE HUMANITARIAN ASSISTANCE TO THE COMPLEX EMERGENCY IN ARMENIA

DOD SUPPLEMENTAL IMPACT AID

IMAGING AND GENETICS IN HUNTINGTON'S DISEASE