University Of Mississippi

INSTITUTIONAL PORTION--CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

MISSISSIPPI CENTER FOR CLINICAL AND TRANSLATIONAL RESEARCH

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

SCIENCE BASED AUTHENTICATION OF DIETARY SUPPLEMENTS

TELEHEALTH CENTER OF EXCELLENCE

CARDIOVASCULAR DYNAMICS AND THEIR CONTROL

CADIORENAL AND METABOLIC DISEASES RESEARCH CENTER

MISSISSIPPI CENTER OF EXCELLENCE IN PERINATAL RESEARCH

UNIVERSITY OF MISSISSIPPI MEDICAL CENTER BIOTECHNOLOGY RESEARCH PARK

THE UNIVERSITY OF MISSISSIPPI RESEARCH PARK

HEALTH CARE AND OTHER FACILITIES

VALUE-BASED MEDICAL STUDENT EDUCATION TRAINING PROGRAM

2009 THE INSTITUTE FOR THE IMPROVEMENT OF MINORITY HEALTH AND HEALTH DISPARITIES IN THE DELTA REGION

THE NATIONAL INSTITUTE FOR UNDERSEA SCIENCE AND TECHNOLOGY - 2007-2010 UNDERSEA RESEARCH IN BITOTECHNOLOGY AND ENVIRNMENTAL TECHNOLOGY

GLYCORE: GLYCOSCIENCE CENTER OF RESEARCH EXCELLENCE

VALUE-BASED MEDICAL STUDENT EDUCATION TRAINING PROGRAM

PHASE II CONSTRUCTION OF NCNPR RESEARCH WING

HEALTH CARE AND OTHER FACILITIES

ARIC NEUROCOGNITIVE STUDY

EARLY CHILDHOOD HEALTH PROMOTION SYSTEM FOR HIGH NEED PROGRAM

MOLECULAR CENTER OF HEALTH AND DISEASE - OVERALL-ABSTRACT CHRONIC DISEASES, SUCH AS HEART DISEASE, DIABETES, AND CANCER ARE AMONG THE MOST PREVALENT HEALTH CONDITIONS IN THE UNITED STATES, RESPONSIBLE FOR 7 OUT OF EVERY 10 DEATHS. MISSISSIPPI RANKS FIRST OR SECOND IN 8 OF 10 LEADING CAUSES OF DEATH, WITH 90% OF THE POPULATION HAVING 1-2 CHRONIC DISEASES. WHILE CHRONIC DISEASES CAN BE TREATED THROUGH EARLY INTERVENTION, TARGETED MEDICAL THERAPIES, AND IMPROVED DIET AND EXERCISE, AN UNDERSTANDING OF GENETIC SUSCEPTIBILITY AND MOLECULAR MECHANISMS INVOLVED IN DISEASE ONSET HAS THE POTENTIAL TO HALT PROGRESSION AND RETURN AN INDIVIDUAL TO A HEALTHIER STATE. ADVANCES IN TECHNOLOGY NOW ALLOW FOR UNPRECEDENTED INSIGHT INTO GENOME COMPLEXITY AND ITS INTERACTION WITH THE ENVIRONMENT USING GENOMIC, TRANSCRIPTOMIC, PROTEOMIC, AND METABOLOMIC DATASETS. THE INTEGRATION OF THESE DATASETS WITH PHYSIOLOGICAL INFORMATION USING COMPUTATIONAL APPROACHES CAN PROVIDE SYSTEMATIC INSIGHT INTO THE MOLECULAR, CELLULAR, AND OVERALL PHYSIOLOGY ASSOCIATED WITH THE HEALTH-DISEASE CONTINUUM. WE PROPOSE TO ESTABLISH A NEW PHASE I COBRE, THE MOLECULAR CENTER OF HEALTH AND DISEASE (MCHD) TO FACILITATE RESEARCH UNDER A CENTRAL THEME OF MOLECULAR PHYSIOLOGY TO ENHANCE THE DEPTH OF EDUCATION, MENTORSHIP, AND TRAINING OF RESEARCHERS TO GENERATE UNIQUE OPPORTUNITIES IN THE APPLICATION OF OMICS TECHNOLOGY AND COMPUTATIONAL BIOLOGY. THE MCHD WILL BE COMPRISED OF MULTIPLE COMPONENTS INCLUDING AN ADMINISTRATIVE UNIT, EDUCATION AND MENTORING PROGRAMS, A PILOT PROJECT PROGRAM, TWO RESEARCH CORES, AND THREE MAJOR PROJECT INVESTIGATORS. THE OVERALL OBJECTIVES OF THE MCHD ARE: (1) TO DEVELOP INFRASTRUCTURE AND STATE-OF- THE-ART RESEARCH CORE FACILITIES ESSENTIAL FOR CUTTING EDGE BASIC, CLINICAL, AND TRANSLATIONAL APPROACHES TO STUDY THE HEALTH AND DISEASE CONTINUUM. THE MCHD, THROUGH CORE B WILL ENHANCE EXISTING -OMICS TECHNOLOGY (E.G., SINGLE CELL RNASEQ AND SPATIAL TRANSCRIPTOMICS), PROTEOMIC CAPABILITIES, AND ESTABLISH A NEW INNOVATIVE CORE, INVOLVING CRISPR/CAS9 GENE-EDITING TECHNOLOGY TO INTERROGATE GENE FUNCTION AND BIOLOGICAL PATHWAYS; AND CORE C WILL ESTABLISH CRITICAL COMPUTING INFRASTRUCTURE AND COMPUTATIONAL BIOLOGY ANALYSIS NOT CURRENTLY AVAILABLE AT THE UNIVERSITY; (2) TO ESTABLISH MEANINGFUL EDUCATION, MENTORING PROGRAMS, AND RESEARCH SUPPORT FOR PROMISING NEW INVESTIGATORS TO NURTURE THEM INTO PRODUCTIVE, INDEPENDENTLY FUNDED INVESTIGATORS, WHO WILL BE EFFECTIVE COLLABORATORS ON MULTIDISCIPLINARY RESEARCH TEAMS. THIS WILL BE ACCOMPLISHED THROUGH OFFERING A “GENETIC AND - OMICS ACADEMY” (DIDACTIC INSTRUCTION AND OBSERVERSHIP) TO STRENGTHEN RESEARCHER UNDERSTANDING OF MOLECULAR AND COMPUTATIONAL APPROACHES, A ROBUST MENTORING PROGRAM INVOLVING ONE-ON-ONE AND TEAM MENTORING, CAREER DEVELOPMENT OPPORTUNITIES, AND PROVIDING A HIGH LEVEL OF RESEARCH SUPPORT THROUGH EACH CORE; AND (3) TO ENHANCE COLLABORATIONS AND INTERACTIONS AMONG INVESTIGATORS ACROSS MULTIPLE DISCIPLINES AT UMMC, PROMOTE COOPERATION BETWEEN OTHER IDEA SUPPORTED PROGRAMS, INCLUDING EXISTING COBRE, IDEA-CTR, AND EXTERNAL PARTNERSHIP WITH THE MISSISSIPPI-INBRE.

CENTER OF RESEARCH EXCELLENCE IN NATURAL PRODUCTS NEUROSCIENCE (CORE-NPN)

DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCTS FOR PHARMACEUTICAL AND AGRICHEMICAL APPLICATIONS II - THE OVERALL GOAL OF THIS PROJECT IS TO DISCOVER, DEVELOP AND FOSTER COMMERCIALIZATION OF NEW BIOACTIVE PRODUCTS AS NEW PHARMACEUTICALS OR AGRICHEMICALS, AND TO IDENTIFY, CHARACTERIZE AND DEVELOP PLANTS FOR PRODUCTION OF PHARMACEUTICALS OR PESTICIDES AS POTENTIAL ALTERNATIVE CROPS.

CORBE: CENTER FOR PSYCHIATRIC NEUROSCIENCE

HEALTH CARE AND OTHER FACILITIES

AWARE IN MISSISSIPPI (AIM) - SUMMARY: AWARE IN MISSISSIPPI (AWARE MS) IS A PARTNERSHIP BETWEEN THE MS DEPARTMENT OF EDUCATION (MDE), THE MS ACHIEVEMENT SCHOOL DISTRICT (MASD), MS DEPARTMENT OF MENTAL HEALTH (MDH), OUR STATE’S FEDERATION OF FAMILIES ORGANIZATION, COMMUNITY PROVIDERS, AND MULTIPLE PROGRAMS ACROSS THREE MS UNIVERSITIES (MSU, USM, UMMC). AWARE MS AIMS TO INCREASE MENTAL HEALTH AWARENESS, FOSTER RESILIENCE, AND STRENGTHEN ACCESS TO TRAUMA-INFORMED, CULTURALLY RESPONSIVE, AND FAMILY DRIVEN MENTAL HEALTH SERVICES AND SUPPORTS IN HUMPHREYS COUNTY AND YAZOO CITY SCHOOL DISTRICTS (THE LEAS). BOTH DISTRICTS ARE HOUSED WITHIN THE MASD, A DISTINCT SEA THAT AIMS TO TRANSFORM PERSISTENTLY FAILING MS PUBLIC SCHOOLS. LED BY THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, AWARE MS WILL COLLABORATE TO DEVELOP AND IMPROVE A SCHOOL-BASED CONTINUUM OF AWARENESS, PREVENTION, TRAINING, AND SERVICE LINKAGE AND DELIVERY FOCUSED ON THE MASD AND PRIMED TO SCALE TO OTHER MISSISSIPPI LEAS ACROSS THE STATE. POPULATION: 3250 SCHOOL-AGED YOUTH (K-12) AND 535 SCHOOL STAFF IN HUMPHREYS AND YAZOO CITY SCHOOL DISTRICTS. BOTH MASD DISTRICTS ARE LOCATED IN THE MISSISSIPPI (MS) DELTA REGION, A RURAL AND UNDERSERVED REGION WITH SIGNIFICANT RATES OF CHILD ADVERSITY AND POVERTY. MASD DISTRICTS HAVE SIGNIFICANTLY HIGHER PROPORTIONS OF BLACK YOUTH (HUMPHREYS = 97%; YAZOO CITY = 98%) THAN STATE AVERAGES. PREVALENCE OF CHILDHOOD MENTAL HEALTH (MH) DISORDERS IN MS IS HIGHER (20%) THAN U.S. ESTIMATES, AND NEARLY 66% DO NOT RECEIVE TREATMENT—THE WORST RATE IN THE U.S. BOTH MASD DISTRICTS ARE IN HRSA-DESIGNATED MENTAL HEALTH PROFESSIONAL SHORTAGE AREAS. GOAL 1. INCREASE AWARENESS AND LITERACY AMONG TEACHERS, SCHOOL-BASED STAFF, CAREGIVERS, AND COMMUNITY ORGANIZATIONS TO IDENTIFY AND RESPOND EFFECTIVELY TO SCHOOL AGED YOUTH MH PROBLEMS AND CO-OCCURRING NEEDS. KEY OBJECTIVES: IMPLEMENT MH AWARENESS, SUICIDE PREVENTION AND POSTVENTION PROGRAMS; DISSEMINATE A TRAUMA-INFORMED TOOLKIT FOR SCHOOL STAFF AND PARENTS. EXPECTED TO REACH A 4-YEAR TOTAL OF 2200 UNIQUE INDIVIDUALS. GOAL 2. ENHANCE RESILIENCY AND MH WELL-BEING FOR ALL SCHOOL-AGED YOUTH THROUGH IMPLEMENTATION OF A SOCIAL-EMOTIONAL LEARNING (SEL) CURRICULUM INTEGRATED INTO GENERAL CURRICULUM AND LINKED TO SCHOOL-WIDE IMPLEMENTATION OF TRAUMA-INFORMED PRINCIPLES. KEY OBJECTIVES: IMPLEMENT SEL CURRICULUM AND TRAINING WITH TEACHERS TO PROMOTE SEL IN STUDENTS. OFFER TRAUMA-INFORMED TRAININGS TO YOUTH SERVING ADULTS AND PARENTS. EXPECTED TO REACH A 4-YEAR TOTAL OF 1830 UNIQUE INDIVIDUALS ACROSS STUDENTS, TEACHERS, SCHOOL STAFF, AND PARENTS. GOAL 3. IMPROVE A MULTI-TIERED SYSTEM OF SUPPORT VIA A ROBUST SUITE OF TRAINING AND WORKFORCE CAPACITY BUILDING ACTIVITIES TO SCHOOL STAFF AND PARENTS THAT PROVIDES MH PROMOTION, PREVENTION, AND INTERVENTION SERVICES ALONG A PUBLIC HEALTH CONTINUUM TO MEET STUDENTS’ NEEDS. KEY OBJECTIVES: SCHOOL-WIDE UNIVERSAL SCREENING FOR MH, ADVERSE CHILDHOOD EXPERIENCES AND SUICIDALITY; IMPLEMENT SUITE OF UNIVERSAL PREVENTION PROGRAMS; PROVIDE ON-DEMAND CONSULTATION AND DISTANCE LEARNING FOR MENTAL HEALTH THERAPISTS. EXPECTED TO REACH A 4-YEAR TOTAL OF 9100. GOAL 4. INCREASE AND IMPROVE STUDENT AND FAMILY ACCESS TO CULTURALLY RELEVANT, AND TRAUMA-INFORMED SCHOOL AND COMMUNITY-BASED ACTIVITIES AND SERVICES THROUGH A COORDINATED SYSTEM OF CARE ACROSS LEAS, COMMUNITY AGENCIES, AND LEA, SEA, AND SCHOOL-BASED POLICY DEVELOPMENT. KEY OBJECTIVES: COORDINATE COMMUNITY REFERRAL PATHWAYS, DEVELOP/IMPLEMENT (A)CRISIS RESPONSE AND (B) SCHOOL SAFETY AND THREAT/VIOLENCE PREVENTION PLAN WITH MULTIDISCIPLINARY TEAM. EXPECTED TO REACH A 4-YEAR TOTAL OF 200 INDIVIDUALS.

EARLY CHILDHOOD HEALTH PROMOTION SYSTEM FOR HIGH NEED PROGRAM

IMPROVE EXISTING AIRPORT

HYPERTENSION AND CARDIORENAL DISEASES RESEARCH TRAINING PROGRAM

CENTER OF RESEARCH EXCELLENCE IN NATURAL PRODUCTS NEURO*

SPIRULINA ORAL SUPPLEMENT FOR ENHANCING HOST RESILIENCE TO VIRUS INFECTION

LASER STANDOFF DETECTION OF BURIED HAZARDS USING ACOUSTIC/SEISMIC STIMULI

CHILD NUTRITION DISCRETIONARY GRANTS LIMITED AVAILABILITY

RII TRACK-2 FEC: FEEDING AND POWERING THE WORLD - CAPTURING SUNLIGHT TO SPLIT WATER AND GENERATE FERTILIZER AND FUELS

ANXIOLYTIC EFFECTS AND ABUSE OF BZ RECEPTOR LIGANDS

¿¿DEVELOPMENT OF SAFER DRUGS FOR MALARIA AND LEISHMANIASIS IN US TROOPS, CIVILIAN PERSONNEL AND TRAVELERS¿¿

CENTER FOR PSYCHIATRIC NEUROSCIENCE

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

COBRE PHASE III TRANSITIONAL CENTER

CARDIORENAL AND METABOLIC DISEASES RESEARCH CENTER - PROJECT SUMMARY/ABSTRACT CARDIOVASCULAR (CV), RENAL AND METABOLIC DISEASES ARE HIGHLY PREVALENT IN THE U.S., ESPECIALLY IN MISSISSIPPI. WE ESTABLISHED THE CARDIORENAL AND METABOLIC DISEASES RESEARCH CENTER (CMDRC) AT THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER TO BRING TOGETHER A MULTIDISCIPLINARY GROUP OF BASIC, CLINICAL AND POPULATION SCIENTISTS WORKING ON CV, RENAL, AND METABOLIC DISEASES. UNDERSTANDING THE COMPLEX RELATIONSHIP BETWEEN THESE CHRONIC DISEASES REQUIRES THE COMBINED EFFORTS OF BASIC, CLINICAL AND POPULATION SCIENTISTS USING INNOVATIVE MULTIDISCIPLINARY INTEGRATIVE APPROACHES TO RESEARCH AND STATE-OF-THE-ART TECHNOLOGIES THAT FACILITATE DISCOVERY. THE MOLECULAR BASES FOR INTERDEPENDENCE OF CV, RENAL, AND METABOLIC DISEASES HAVE CLASSICALLY BEEN STUDIED VIA GENOMICS, TRANSCRIPTOMICS, AND PROTEOMICS PLATFORMS THAT ASSESS DNA SEQUENCES AND LEVELS OF RNA AND PROTEIN EXPRESSION. WHILE DATA GENERATED FROM THESE STUDIES ARE INFORMATIVE, REGULATION OF COMPLEX BIOLOGICAL SYSTEMS ALSO REQUIRES UNDERSTANDING PROTEIN ACTIVITY. PROTEIN KINASES ARE CENTRAL TO GOVERNING PROTEIN ACTIVITY NETWORKS AND LINK SEVERAL REGULATORY ELEMENTS, INCLUDING TRANSCRIPTION FACTORS, CHAPERONES, AND STRUCTURAL PROTEINS. THE KINOME REFERS TO THE BROAD-BASED ACTIVITY OF THE COMPLETE SET OF PROTEIN KINASES. SEVERAL METHODS HAVE RECENTLY BEEN DEVELOPED TO STUDY THE KINOME IN LIGHT OF THE VAST ACTIVITY OF PROTEIN KINASES. ONE OF THESE NEW TECHNOLOGIES IS THE PAMCHIP WHICH USES HUNDREDS OF ~13 RESIDUE-LONG REPORTER PEPTIDES WHICH ARE PHOSPHORYLATED WITH SAMPLES DERIVED FROM CELL CULTURES, TISSUES, OR CLINICAL BIOPSIES. THE DEGREE OF PHOSPHORYLATION IS MEASURED IN REAL-TIME USING FLUORESCENT ANTIBODIES. THIS TECHNOLOGY IS ENCOMPASSED IN THE PAMSTATION 12 FROM PAMGENE. THIS EQUIPMENT SUPPLEMENT APPLICATION IS FOR FUNDS TO PURCHASE A PAMSTATION 12 FOR THE CMDRC. THE ACQUISITION OF THIS STATE-OF-THE-ART SYSTEM WILL ALLOW INVESTIGATORS OF THE PARENT COBRE TO DETERMINE THE ROLE OF THE KINOME IN THE AREAS OF CV, RENAL, AND METABOLIC DISEASES. THIS NEW EQUIPMENT WILL ALSO INCREASE THE SOPHISTICATION OF EXPERIMENTAL APPROACHES AND STRENGTHEN FUTURE NIH GRANTS FROM CMDRC INVESTIGATORS AS WELL AS OTHER INVESTIGATORS AT UMMC, INCLUDING THOSE SUPPORTED BY OTHER NIGMS FUNDED IDEA CENTERS. THE CMDRC HAS BEEN A MAJOR DRIVER FOR MARKED EXPANSION OF CARDIORENAL AND METABOLIC DISEASES RESEARCH IN MISSISSIPPI. THIS LARGE EQUIPMENT GRANT WILL AMPLIFY AND ENSURE SUSTAINABILITY OF OUR EFFORTS TO DEVELOP A HIGHLY PRODUCTIVE CMDRC DEDICATED TO IMPROVING LIVES THROUGH RESEARCH, DISCOVERY, AND INNOVATION.

REMOTE INFRASONIC MONITORING OF NATURAL HAZARDS

MISSISSIPPI DRUG-USE REDUCTION PROGRAM

CN NFSMI

CN NFSMI

CN NFSMI

CN NFSMI

CHILD NUTRITION DISCRETIONARY GRANTS LIMITED AVAILABILITY

CHILD NUTRITION DISCRETIONARY GRANTS LIMITED AVAILABILITY

CHILD NUTRITION DISCRETIONARY GRANTS LIMITED AVAILABILITY

CHILD NUTRITION DISCRETIONARY GRANTS LIMITED AVAILABILITY

CHILD NUTRITION DISCRETIONARY GRANTS LIMITED AVAILABILITY

CHILD NUTRITION DISCRETIONARY GRANTS LIMITED AVAILABILITY

CHILD NUTRITION DISCRETIONARY GRANTS LIMITED AVAILABILITY

NATIONAL STEM TEACHER CORPS PILOT PROGRAM: MISSISSIPPI STEM EDUCATION ALLIANCE -THE NATIONAL STEM TEACHER CORPS PILOT PROGRAM REGIONAL ALLIANCE PROJECT AIMS TO RECOGNIZE OUTSTANDING STEM EDUCATORS IN HIGH-NEED SCHOOLS THAT ADVANCE EDUCATIONAL EXCELLENCE IN THE SOUTHEAST REGION. THIS PROJECT WILL SUPPORT 16 STEM TEACHER CORPS MEMBERS BY RECOGNIZING AND REWARDING THEIR ACCOMPLISHMENTS AND EFFORT TO ENHANCE MATHEMATICS TEACHING AND LEARNING IN SECONDARY SCHOOLS. THE PROJECT WILL ALSO PROVIDE PROFESSIONAL DEVELOPMENT, MENTORSHIP AND SUPPORT TO 100 OTHER TEACHERS OF MATHEMATICS BY SUPPORTING THE MISSISSIPPI STEM EDUCATION ALLIANCE (MESA). THIS ALLIANCE WILL WORK TO RECOGNIZE EXEMPLARY MATHEMATICS TEACHERS AND COLLABORATE WITH THEM TO DESIGN AND FACILITATE PROFESSIONAL DEVELOPMENT OPPORTUNITIES FOR MATHEMATICS TEACHERS ACROSS THE STATE. TEACHER CORPS MEMBERS WILL ALSO SHARE THEIR EXPERIENCES WITH OTHER TEACHERS AND SUPPORT TEACHERS IN RURAL COMMUNITIES TO GAIN THE CONTENT KNOWLEDGE AND CERTIFICATIONS NEEDED TO EFFECTIVELY TEACH SECONDARY MATHEMATICS. THESE NATIONAL STEM TEACHER CORPS MEMBERS WILL GAIN RECOGNITION AS MODELS TO WHICH IN-SERVICE AND PRE-SERVICE TEACHERS CAN ASPIRE. THIS PROJECT AT THE UNIVERSITY OF MISSISSIPPI INCLUDES PARTNERSHIPS WITH THE MISSISSIPPI DEPARTMENT OF EDUCATION AND LOCAL SCHOOL DISTRICTS IN EACH CONGRESSIONAL DISTRICT ACROSS THE STATE. THE GOALS OF THE PROJECT AIM TO SUPPORT TEACHERS WHO WILL SERVE AS FACILITATORS, WORKING WITH ALLIANCE PARTNERS TO CREATE PROFESSIONAL DEVELOPMENT INSTITUTES AND DESIGN A STATISTICS AND DATA LITERACY COURSE FOR MISSISSIPPI HIGH SCHOOL STUDENTS. THE NATIONAL STEM TEACHER CORPS MEMBERS WILL BE TRAINED TO SERVE AS PROFESSIONAL DEVELOPMENT FACILITATORS WHO WILL IMPACT OTHER TEACHERS AND HELP THEM OBTAIN SUPPLEMENTAL TEACHING ENDORSEMENTS IN CRITICAL CONTENT SHORTAGE AREAS. THIS PROGRAM AIMS TO ENDORSE AN ESTIMATED 100 ADDITIONAL TEACHERS IN MIDDLE SCHOOL MATHEMATICS, ALGEBRA, AND GEOMETRY WITHIN FIVE YEARS, ENSURING THAT STUDENTS HAVE ACCESS TO ROBUST LEARNING OPPORTUNITIES. THE PROGRAM WILL COLLECT PRE- AND POST-ASSESSMENT DATA TO MEASURE THE IMPACT ON TEACHER CONTENT KNOWLEDGE. ADDITIONALLY, THE MISSISSIPPI STEM EDUCATION ALLIANCE WILL ESTABLISH AN ONLINE HUB THAT WILL CONSOLIDATE INFORMATION RELATED TO PROFESSIONAL DEVELOPMENT AND STUDENT OPPORTUNITIES. THIS ONLINE INFORMATION HUB WILL BE AVAILABLE TO ALL MISSISSIPPI STEM TEACHERS AND WILL BE USED TO CONNECT THE STEM LEARNING EFFORTS OF ALL MISSISSIPPI STEM EDUCATION ALLIANCE PARTNERS. THE NSF NATIONAL STEM TEACHER CORPS PILOT PROGRAM SUPPORTS OUTSTANDING STEM EDUCATORS IN HIGH-NEED SCHOOLS THAT ADVANCE EDUCATIONAL EXCELLENCE IN OUR NATION?S PREK-12 CLASSROOMS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

CHILD NUTRITION DISCRETIONARY GRANTS LIMITED AVAILABILITY

CHILD NUTRITION DISCRETIONARY GRANTS LIMITED AVAILABILITY

CHILD NUTRITION DISC

ENHANCING MENTAL HEALTH PROVIDERS OPPORTUNITIES WITH EDUCATIONAL RESOURCES IN SCHOOLS (EMPOWERS)

2006 MISSISSIPPI INSTITUTE FOR IMPROVEMENT OF GEOGRAPHIC MINORITY HEALTH AND HEALTH DISPARITIES

DETERRENTS FOR PRESCRIPTION OPIOID ABUSE

DEVELOPMENT OF SAFER DRUGS FOR MALARIA AND LEISHMANIASIM IN US TROOPS, CIVILIAN PERSONNEL AND TRAVELERS

MISSISSIPPI PEDIATRIC CLINICAL TRIALS CENTER

CLINICAL AND GENETIC CORRELATES OF VASCULAR FUNCTION IN AFRICAN AMERICANS: JHS

DISCRETIONARY

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - THE LANDSCAPE OF PHARMACEUTICAL MANUFACTURING IS RAPIDLY EVOLVING, WITH INCREASING DEMANDS FOR PERSONALIZED MEDICATIONS, RAPID PROTOTYPING, AND FLEXIBLE MANUFACTURING PROCESSES. TRADITIONAL MANUFACTURING METHODS OFTEN LACK THE AGILITY AND FLEXIBILITY REQUIRED TO MEET THESE EVOLVING NEEDS EFFICIENTLY. ON-DEMAND PHARMACEUTICAL MANUFACTURING OFFERS A SOLUTION BY ENABLING THE PRODUCTION OF SMALL BATCHES OF MEDICATIONS TAILORED TO INDIVIDUAL PATIENT REQUIREMENTS OR SPECIFIC HEALTH CARE NEEDS. THESE INNOVATIONS WILL HELP US ACHIEVE HEALTH EQUITY THROUGH ACCESS TO MEDICATIONS AND IMPROVED PATIENT OUTCOMES. IN LINE WITH OUR COMMITMENT TO INNOVATION AND ADVANCEMENT IN PHARMACEUTICAL RESEARCH AND DEVELOPMENT, WE PROPOSE THE ACQUISITION OF STATE-OF-THE-ART EQUIPMENT TO ENHANCE OUR CAPABILITIES IN ON-DEMAND PHARMACEUTICAL MANUFACTURING, INCLUDING DOSAGE FORM CHARACTERIZATION AND POINT-OF-CARE COMPOUNDING. THIS INVESTMENT WILL NOT ONLY FACILITATE OUR RESEARCH AND DEVELOPMENT ENDEAVORS BUT ALSO SERVE AS A PIVOTAL RESOURCE FOR MEETING HEALTH CARE NEEDS AND TRAINING FUTURE PHARMACISTS AND PHARMACEUTICAL SCIENTISTS.

PLEASE SEE THE ABSTRACT FILE THAT HAS BEEN UPLOADED TO THE APPLICATION KIT PER INSTRUCTIONS IN THE NOTICE OF FUNDING OPPORTUNITY

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

NASA SPACE GRANT IN MISSISSIPPI

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - AS THE STATE'S ONLY LEVEL I TRAUMA CENTER AS WELL AS THE STATE’S ONLY CHILDREN’S HOSPITAL, THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER (UMMC) IS ACCUSTOMED TO CARING FOR PATIENTS FROM ACROSS THE STATE WHO ARE AT THE HIGHEST LEVEL OF EMERGENCY MEDICAL NEED. FOLLOWING THE OCTOBER 2022 CLOSURE OF THE STATE OF MISSISSIPPI’S ONLY DEDICATED BURN UNIT AT MERIT HEALTH CENTRAL HOSPITAL, UMMC HAS STEADILY DEVELOPED ITS RESPONSE TO MISSISSIPPIANS NEEDING BURN CARE CLOSE TO HOME BY EXPANDING ITS CAPABILITIES AND COORDINATION OF CARE FOR PATIENTS WITH BURN INJURIES. THE MISSISSIPPI STATE DEPARTMENT OF HEALTH DESIGNATED UMMC AS A MISSISSIPPI BURN CENTER IN APRIL 2023. ALSO IN 2023, UMMC WAS AWARDED $2,000,000 IN ONE-TIME STATE APPROPRIATIONS PASSED THROUGH BY THE MISSISSIPPI STATE DEPARTMENT OF HEALTH TO HELP DEFRAY THE COST OF CONSTRUCTING AND EQUIPPING A BURN CENTER. TO COVER THE REMAINING EXPENSE OF CONSTRUCTING AND EQUIPPING A BURN UNIT WITHIN EXISTING HOSPITAL SPACE ON THE MEDICAL CENTER’S MAIN CAMPUS, UMMC ALSO SEEKS $4,300,000 IN FUNDING THROUGH HRSA’S COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING PROGRAM. FUNDS RECEIVED THROUGH THIS AWARD APPLICATION WILL GO TOWARDS THE DESIGN, DEMOLITION, RENOVATION, AND EQUIPPING OF A DEDICATED AND SPECIALIZED INPATIENT BURN UNIT. THE BURN UNIT WILL PROVIDE MUCH-NEEDED IN-STATE BURN CARE FOR MISSISSIPPIANS, WITH THE CAPABILITY OF TREATING PATIENTS REQUIRING VARYING LEVELS OF CARE AND WITH THE ABILITY TO PROVIDE THERAPEUTIC AND REHABILITATIVE CARE TO PATIENTS WHILE THEY ARE IN THE HOSPITAL. UMMC HAS A MULTIFACETED CARE TEAM FOR BURN PATIENTS THAT WILL INCLUDE SPECIALISTS IN EMERGENCY MEDICINE AND TRAUMA SURGERY, AS WELL AS SEVERAL SUB-SPECIALTIES IN PLASTIC SURGERY, CRITICAL CARE, LABORATORY MEDICINE, MENTAL HEALTH, NURSING, OCCUPATIONAL THERAPY, PHARMACISTS AND PHYSICAL THERAPY. THIS COLLABORATION BENEFITS MISSISSIPPIANS IN NEED OF A WIDE RANGE OF SPECIALISTS CENTRAL TO THEIR HEALING A ND RECOVERY FROM BURN INJURIES.

CIDA (CENTER FOR INNOVATION AND DISCOVERY IN ADDICTIONS) MISSISSIPPI HORIZONS PROJECT - THE CENTRAL AIM OF THE CIDA MISSISSIPPI HORIZON'S PROJECT IS, ON A STATEWIDE BASIS, TO LEVERAGE UMMC'S EXISTING MENTAL HEALTH AND TECHNOLOGY CLINICAL EXPERTISE AND RESOURCES TO EFFICIENTLY FILL GAPS IN ACCESS TO CARE, ACCESS TO TREATMENT, AND AVAILABILITY OF EVIDENCE BASED TREATMENT. UMMC, SPECIFICALLY THE CENTER FOR INNOVATION AND DISCOVERY IN ADDICTIONS (CIDA) AND THE DEPARTMENT OF PSYCHIATRY AND HUMAN BEHAVIOR, SEEKS TO FILL CARE GAPS BY PROVIDING EVALUATION AND LINKAGE TO SERVICES IN REAL TIME, WITH A FOCUS ON INCREASING AND IMPROVING ACCESS FOR PATIENTS IN RURAL AREAS. SPECIFICALLY, WE WILL: 1. OFFER 7 DAY/WEEK 7PM TO 7AM AVAILABILITY VIA OUR EXISTING TELEHEALTH INFRASTRUCTURE OF BOTH A LICENSED MENTAL HEALTH PROVIDE POSSESSING COMPETENCE IN SUBSTANCE USE DISORDERS AND A LICENSED PEER SUPPORT SPECIALIST. EVENING AVAILABILITY OF SERVICES WILL COMPLEMENT TELE-BEHAVIORAL HEALTH CONSULTATION PROVIDED DURING LIMITED DAYTIME HOURS. THIS CAPABILITY WOULD REDUCE UNNECESSARY TRANSFERS, ENSURE PATIENTS RECEIVE APPROPRIATE TREATMENT AND REDUCE THE OVERALL COST OF CARE FOR THESE PATIENT POPULATIONS. 2. FOR THOSE WITH OPIOID USE DISORDER, WE WILL PROVIDE IMMEDIATE AND SEAMLESS LINKAGE TO UMMC'S WELL-ESTABLISHED TELEMAT PROGRAM, AND FOR THOSE WITH ONGOING MENTAL HEALTH AND/OR SUBSTANCE ABUSE NEEDS, LINKAGE TO COMMUNITY RESOURCES. 3. STANDING UP A WEB BASED STATEWIDE PORTAL PROVIDING ACCESS TO ACCURATE, REAL TIME INFORMATION ON AVAILABILITY OF SUBSTANCE USE TREATMENT SLOTS. THIS PORTAL WILL PROVIDE TIMELY AND EFFICIENT ACCESS TO INFORMATION ESSENTIAL FOR REFERRAL AND APPLICATION FOR TREATMENT. SIMILAR FUNCTIONALITY HAS BEEN IMPLEMENTED IN KENTUCKY, DELAWARE, ALASKA, NEW MEXICO, AND SEVERAL OTHER STATES. 4. THROUGH CIDA'S ACADEMY OF ADDICTION TRAINING, WE WILL PROVIDE REGULAR EDUCATION AND TRAINING TO CLINICIANS, MEDICAL PROVIDERS, CONSUMERS AND THEIR FAMILIES ON TOPICS KEY TO IMPROVING ACCESS AND TREATMENT FOR THOSE WITH MENTAL HEALTH AND SUBSTANCE ABUSE DISORDERS. IN SUM, UTILIZING EXISTING TELEHEALTH INFRASTRUCTURE AND EMPIRICALLY VALIDATED APPROACHES TO CARE, WE WILL IMPROVE PATIENT MANAGEMENT AND QUALITY OF CARE. TAKEN IN ITS TOTALITY, THIS PROPOSAL WILL FILL MENTAL HEALTH AND SUBSTANCE ABUSE ACCESS AND TREATMENT AGAPS ACROSS ALL OF MISSISSIPPI'S 82 COUNTIES.

A PROPOSAL TO ESTABLISH THE MISSISSIPPI VIOLENCE INJURY PREVENTION (VIP) PROGRAM - PROJECT SUMMARY/ABSTRACT THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER (UMMC), IN PARTNERSHIP WITH FOUR WELL-ESTABLISHED COMMUNITY GROUPS—PEOPLE’S ADVOCACY INSTITUTE, STRONG ARMS OF JXN, OPERATION GOOD, AND THE MISSISSIPPI PUBLIC HEALTH INSTITUTE—PROPOSE TO PARTICIPATE IN THE COMMUNITY LEVEL INTERVENTIONS FOR FIREARM AND RELATED VIOLENCE, INJURY AND MORTALITY PREVENTION (CLIF-VP) RESEARCH NETWORK BY ESTABLISHING THE MISSISSIPPI VIOLENCE INJURY PREVENTION (VIP) PROGRAM. TOGETHER, INDIVIDUAL TEAM MEMBERS REPRESENT COMMUNITY ACTIVISTS AND SEVERAL ACADEMIC DISCIPLINES, INCLUDING EMERGENCY MEDICINE, PSYCHOLOGY, PUBLIC HEALTH, SURVEY RESEARCH, GIS AND REMOTE SENSING, LAW, AND NURSING. MISSISSIPPI HAD THE NATION’S HIGHEST FIREARM MORTALITY RATE IN 2020 AT 28.6 PER 100,000 RESIDENTS. JACKSON, THE STATE’S CAPITAL, HAD A 2021 HOMICIDE RATE OF 97.6 PER 100,000 RESIDENTS, MORE THAN THREE TIMES HIGHER THAN THE STATE AND 15 TIMES HIGHER THAN THE NATIONAL RATE OF 6.5 MURDERS PER 100,000 RESIDENTS. UMMC, WHICH IS THE ONLY LEVEL 1 TRAUMA CENTER IN THE STATE, ADMINISTERED CARE TO 1,129 PATIENTS PRESENTING WITH INJURIES FROM FIREARMS OR RELATED VIOLENCE. AS PART OF THE CLIF-VP RESEARCH NETWORK, THE MISSISSIPPI VIP PROGRAM WILL WORK CLOSELY WITH ITS COORDINATING CENTER, THE OTHER RESEARCH PROJECTS FUNDED THROUGH THIS AGREEMENT, THE CLIF-VP RESEARCH NETWORK’S STAKEHOLDER BOARD(S), STEERING COMMITTEE, AND WORKGROUPS TO SUCCESSFULLY CARRY OUT CROSS-PROJECT ACTIVITIES. THE MISSISSIPPI VIP PROGRAM’S RESEARCH DESIGN INCLUDES A TWO-YEAR PLANNING (UG3) PHASE AND A THREE- YEAR IMPLEMENTATION (UH3) PHASE. TWO SPECIFIC AIMS HAVE BEEN IDENTIFIED FOR THE UG3 PHASE: (1) DEFINE AND CREATE THE MACHINERY TO LONGITUDINALLY MONITOR THE COMMUNITY-LEVEL SOCIAL DETERMINANTS OF FIREARM INJURY IN THE GREATER JACKSON, MISSISSIPPI METROPOLITAN AREA WITH RESPECT TO (A) PERCEIVED NEEDS, (B) AVAILABLE RESOURCES AND THEIR UTILIZATION, AND (C) OPPORTUNITIES FOR CAPACITY BUILDING; AND (2) IDENTIFY PRINCIPAL COMMUNITY-SPECIFIC RISK ELEMENTS FOR (A) FIREARM INJURY, (B) SUBOPTIMAL FUNCTIONAL RECOVERY, AND (C) RETALIATION AND REINJURY, AND COLLABORATIVELY DEVELOP LINKED COMMUNITY- AND HOSPITAL-BASED PROTECTIVE RESOURCES TO ADDRESS THESE RISKS. TWO SPECIFIC AIMS HAVE BEEN IDENTIFIED FOR THE UH3 PHASE: (1) CONDUCT A CLINICAL TRIAL THAT IMPLEMENTS OPTIMIZED COMMUNITY-FOCUSED INTERVENTIONS DURING THE UG3 PHASE USING A STEP-WEDGE CLUSTER APPROACH, AND MEASURES LONGITUDINAL COMMUNITY AND INDIVIDUAL IMPACT OF VIOLENCE PREVENTION INTERVENTIONS ON (A) INCIDENCE OF FIREARM INJURY, (B) FUNCTIONAL VICTIM RECOVERY, (C) INCIDENCE OF RETALIATION AND REINJURY, AND (D) ECONOMIC IMPACT; AND (2) COORDINATE ONGOING COMMUNITY, REGIONAL, AND TELEHEALTH EXPANSION AND ADOPTION OF OPTIMIZED COMMUNITY-FOCUSED RESOURCES IN CONCERT WITH THE CLIF-VP RESEARCH NETWORK.

TOLERANCE AND PHYSICAL DEPENDENCE AFTER CHRONIC BENZODIAZEPINE TREATMENT

HYDRATE RESEARCH ACTIVITIES THAT BOTH SUPPORT AND DERIVE FROM THE MONITORING STATION/SEA-FLOOR OBSERVATORY, MISSISSIPI CANYON 118, NORTHERN GULF OF M

A NOVEL PROTEIN DELIVERY SYSTEM FOR THERAPY OF PREECLAMPSIA

MIDBRAIN CIRCUITRY FOR NEURONAL CONTROL OF GAZE

MISSISSIPPI DIABETES PROJECT: ADVANCING HEALTH EQUITY IN DIABETES CARE AND PREVENTION - MISSISSIPPI PERSISTENTLY HAS AMONG THE HIGHEST RATES OF DIABETES (14.4%) IN THE COUNTRY. THE SOCIO-CULTURAL AND ECONOMIC CONDITIONS IN MOSTLY RURAL AND MEDICALLY UNDERSERVED COMMUNITIES MAKE DIABETES MANAGEMENT AND PREVENTION A FORMIDABLE CHALLENGE FOR INDIVIDUALS AND FAMILIES. THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER (UMMC) PROPOSES TO LEAD THE IMPLEMENTATION AND EVALUATION OF 6 EVIDENCE-BASED STRATEGIES OUTLINED IN COMPONENT B AS A STRATEGIC APPROACH TO ADVANCING HEALTH EQUITY FOR PRIORITY POPULATIONS IN MISSISSIPPI. THE PRIMARY PURPOSE OF THE MISSISSIPPI DIABETES PROGRAM IS TO DEVELOP AND ACTIVATE SUSTAINABLE CLINICAL-COMMUNITY LINKAGES THAT WILL LEAD TO IMPROVED DIABETES OUTCOMES AND DIABETES PREVENTION. THE PROJECT IS ANCHORED IN HEALTH EQUITY AND COMMUNITY ENGAGEMENT AND WILL SEEK TO ADDRESS SOCIAL NEEDS AT THE COMMUNITY (I.E., ESTABLISH FOOD PANTRIES) AND INDIVIDUAL/FAMILIAL (I.E., TRANSPORTATION, HEALTH LITERACY) LEVELS. THE PROJECT TEAM AND PARTNERS PROPOSE TO WORK IN 41 OF MISSISSIPPI’S HIGH-NEEDS COUNTIES TO REACH 1,066,150 MISSISSIPPIANS WITH THE HIGHEST RATES OF DIABETES (GREATER THAN OR EQUAL TO 14%). AS THE ONLY ACADEMIC MEDICAL CENTER IN THE STATE, UMMC WILL SERVE AS THE LEAD ORGANIZATION OF THIS PROPOSAL INCLUDING THE TELEHEALTH CENTER OF EXCELLENCE, MYRLIE EVERS-WILLIAMS INSTITUTE FOR THE ELIMINATION OF HEALTH DISPARITIES, LIFESTYLE MEDICINE, POPULATION HEALTH SCIENCE, AND DATA SCIENCE. THE PROJECT PARTNERS INCLUDE THE COMMUNITY HEALTH CENTER ASSOCIATION OF MISSISSIPPI (CHCAMS), LOCAL COMMUNITY HEALTH CENTERS, THE MISSISSIPPI STATE DEPARTMENT OF HEALTH, COMMUNITY-BASED ORGANIZATIONS, THE MISSISSIPPI STATE UNIVERSITY EXTENSION AGENCY, COUNTY-LEVEL EXTENSION AGENCIES, AND THE MISSISSIPPI FOOD NETWORK. THE CENTER FOR RESEARCH EVALUATION AT THE UNIVERSITY OF MISSISSIPPI WILL LEAD THE PROJECT EVALUATION. THE TARGETED PRIORITY POPULATIONS WHO HAVE SYSTEMATICALLY EXPERIENCED GREATER OBSTACLES TO OPTIMAL HEALTH IN MISSISSIPPI INCLU DE RESIDENTS IN RURAL AND MEDICALLY UNDERSERVED COMMUNITIES, BLACKS OR AFRICAN AMERICANS, AND SOCIOECONOMICALLY DISADVANTAGED FAMILIES. THE TARGETED HIGH-NEEDS COUNTIES INCLUDE ADAMS, AMITE, ATTALA, BOLIVAR, CHICKASAW, CLAIBORNE, CLARKE, CLAY, COAHOMA, COPIAH, COVINGTON, HINDS, HOLMES, HUMPHREYS, ISSAQUENA, JASPER, JEFFERSON, JEFFERSON DAVIS, KEMPER, LAUDERDALE, LEAKE, LEFLORE, MARION, MARSHALL, MONTGOMERY, NESHOBA, NOXUBEE, PANOLA, PIKE, QUITMAN, SCOTT, SHARKEY, SUNFLOWER, TALLAHATCHIE, TUNICA, UNION, WALTHALL, WARREN, WASHINGTON, WINSTON, YAZOO COUNTIES IN MISSISSIPPI. THE PROPOSED PROJECT HAS A HIGH LIKELIHOOD TO IMPROVE DIABETES OUTCOMES AND PREVENTION AND ADVANCE HEALTH EQUITY AMONG MISSISSIPPI’S MOST VULNERABLE RESIDENTS.

IMPLEMENTING, ENHANCING, AND SUSTAINING THE MISSISSIPPI CANCER REGISTRY - THE MISSION OF THE MISSISSIPPI CANCER REGISTRY (MCR) IS TO COLLECT COMPLETE AND HIGH QUALITY CANCER INCIDENCE DATA TO GUIDE PROGRAM PLANNING AND EVALUATION STATEWIDE, MONITOR CANCER TRENDS IN GEOGRAPHIC AREAS AND IN SPECIFIC POPULATIONS, PROVIDE DATA FOR RESEARCH AND PUBLIC HEALTH, AND EDUCATE THE GENERAL PUBLIC AND POLICY MAKERS ON THE BURDEN OF CANCER IN MISSISSIPPI. EACH YEAR, THE MCR SUBMITS DATA TO THE NATIONAL PROGRAM OF CANCER REGISTRIES (NPCR) FOR EVALUATION AND INCLUSION IN NATIONAL CANCER INCIDENCE. THE MCR CONSISTENTLY MEETS THE NATIONAL DATA QUALITY STANDARDS FROM THE CDC. AGGREGATE DATA IS AVAILABLE BY SITE, RACE, SEX, STAGE FOR SCREENABLE CANCERS, AND GEOGRAPHIC AREA THROUGH AN INTERACTIVE WEB SITE FOR PUBLIC USE. INFORMATION ON LIFESTYLE-RELATED CANCERS IS ALSO ON THE MCR WEB SITE. THE GOAL OF THE MCR IS TO CONTINUE TO IMPROVE THE COMPLETENESS, TIMELINESS, QUALITY, AVAILABILITY AND UTILITY OF THE INCIDENCE DATA COLLECTED. TO ACCOMPLISH THIS GOAL, THE MCR WILL INCREASE THE PROPORTION OF PHYSICIAN OFFICES, PATHOLOGY LABORATORIES, HOSPITALS AND CLINICS THAT DIAGNOSE AND TREAT CANCER WHO REPORT TIMELY DATA TO THE MCR IN AN ELECTRONIC FORMAT. THIS WILL BE ACCOMPLISHED THROUGH UTILIZING WEB-BASED ABSTRACTING SOFTWARE AND ELECTRONIC MEDICAL AND LABORATORY RECORDS. THE MCR WILL ALSO PROVIDE COMPREHENSIVE EDUCATION TO BOTH MCR STAFF AND TO CANCER REPORTERS TO ENSURE QUALITY DATA. EDUCATION WILL BE GEARED TOWARD ADDRESSING CHANGES IN CODING RULES, COMMON CODING ERRORS, INCREASING THE NUMBER OF CERTIFIED TUMOR REGISTRARS IN MISSISSIPPI, AND MEETING THE NEEDS OF THE NEW ABSTRACTORS IN THE STATE. LASTLY, THE MCR WILL MAKE THE DATA AVAILABLE TO THE PUBLIC STAKEHOLDERS ACROSS THE STATE. THE MCR WILL FOSTER COLLABORATIVE RELATIONSHIPS WITH PARTNERS IN CANCER CONTROL EFFORTS. PARTNERSHIPS WITH OTHER STATE CANCER REGISTRIES WILL PROMOTE THE SHARING OF IDEAS AND BEST PRACTICES, AS WELL AS, EXCHANGE OF DATA TO ENSURE COMPLETE COLLECTION OF CANCER IN MISSISSIPPI RESIDENTS. THE MCR WILL WORK WITH THE MISSISSIPPI STATE DEPARTMENT OF HEALTH (MSDH) VITAL RECORDS AND STATISTICS TO INCREASE COMPLETENESS OF INCIDENCE DATA THROUGH MATCHING THE MORTALITY DATA AND TO INCREASE THE AVAILABILITY OF AGGREGATE CANCER MORTALITY DATA. THE MCR WILL ALSO PARTNER WITH MSDH TO IMPROVE THE QUALITY OF INCIDENCE DATA THROUGH MATCHING WITH THE HOSPITAL DISCHARGE DATA AND WILL EXPLORE LINKAGES WITH IMMUNIZATION. PARTNERING WITH THE MISSISSIPPI BREAST AND CERVICAL CANCER EARLY DETECTION PROGRAM WILL PROVIDE AN OPPORTUNITY TO IMPROVE THE QUALITY OF THEIR DATA AND THE COMPLETENESS OF INCIDENCE DATA. THE MCR WILL ALSO PARTNER WITH THE MISSISSIPPI PARTNERSHIP FOR COMPREHENSIVE CANCER CONTROL AND OTHER CHRONIC DISEASE PROGRAMS TO INCREASE THE UTILIZATION OF CANCER INCIDENCE DATA IN STATEWIDE EFFORTS AROUND PREVENTION OF CHRONIC DISEASES, CANCER CONTROL AND RESEARCH. THE MISSISSIPPI CANCER REGISTRY WILL ACTIVELY PARTICIPATE IN THE LEADERSHIP TEAM FOR ADDRESSING THE CANCER BURDEN IN MISSISSIPPI. THE ADVISORY COMMITTEE, COMPRISED OF PHYSICIANS AND OTHER STATEWIDE PARTNERS WILL SERVE AS A TECHNICAL ADVISOR TO THE MCR AND A CHAMPION FOR THE USE OF THE MCR DATA THROUGHOUT THE STATE.

EXPERIMENTAL STUDY OF HEAVY FLAVOR PHYSICS AND SSC R&D

IMPLEMENTING, ENHANCING, AND SUSTAINING THE MISSISSIPPI CANCER REGISTRY

GOALS&OBJECTIVES:THE MSSGC GOALS AND OBJECTIVES WERE DEVELOPED AND ADOPTED IN JANUARY, 2015, TO ALIGN Y/ITH NASA STRATEGIC OBJECTIVE 2.4 AND THE NASA

OPIOID REGULATION OF GNRH PULSES

EFFECTS OF YOGA ON CVD RISK FACTORS AMONG AFRICAN AMERICANS: JACKSON HEART STUDY

MISSISSIPPI SPACE GRANT CONSORTIUM

MOLECULAR STRUCTURE DETERMINATION BY MASS SPECTROMETRY AND COMPUTATIONAL MODELING

THE MISSISSIPPI SPACE GRANT CONSORTIUM (MSSGC) IS A STATEWIDE NETWORK OF COLLEGES UNIVERSITIES INDUSTRIES AND PUBLIC SERVICE INSTITUTIONS PROVIDIN

EXPANDING NALOXONE AND FENTANYL TEST STRIP AWARENESS AND ACCESS IN A RURAL COMMUNITY - THE UNIVERSITY OF MISSISSIPPI SCHOOL OF PHARMACY (UMSOP), IN COLLABORATION WITH COMMUNITY PHARMACIES AND STAKEHOLDERS ACROSS NORTH MISSISSIPPI, PROPOSES A COMPREHENSIVE INITIATIVE TO ADDRESS OPIOID-RELATED EMERGENCIES AMONG COLLEGE AND HIGH SCHOOL STUDENTS. THROUGH ESTABLISHED PARTNERSHIPS WITH COMMUNITY PHARMACY ENHANCED SERVICES NETWORKS (CPESN) AND MISSISSIPPICARE (MC), THIS PROJECT AIMS TO IMPLEMENT A PHARMACIST-LED, SCHOOL-BASED NALOXONE AND FENTANYL TESTING STRIP (FTS) ACCESSIBILITY PROGRAM. THE PROPOSED PROJECT WILL USE A "TRAIN THE TRAINER" APPROACH TO EDUCATE COMMUNITY PHARMACISTS AND STUDENT PHARMACISTS FROM UMSOP IN DELIVERING NALOXONE AND FTS TRAINING TO UNIVERSITY OF MISSISSIPPI AND HIGH SCHOOL STUDENTS. THE TRAINING CURRICULUM WILL BE DEVELOPED BY UMSOP FACULTY PHARMACISTS IN CONJUNCTION WITH THE MISSISSIPPI STATE DEPARTMENT OF HEALTH (MSDH), INCORPORATING IN-PERSON WORKSHOPS WITH ADDITIONAL ONLINE RESOURCES. FOCUSED ON THE 28 MEDICALLY UNDERSERVED COUNTIES IN NORTHERN MISSISSIPPI, WHERE HEALTH OUTCOMES ARE REGULARLY BELOW NATIONAL AVERAGES, THE INITIATIVE TARGETS UNIVERSITY OF MISSISSIPPI COLLEGE STUDENTS AND HIGH SCHOOL STUDENTS (GRADES 9-12). BY EQUIPPING STUDENTS WITH KNOWLEDGE OF OPIOID OVERDOSE SYMPTOMS, NALOXONE ADMINISTRATION, AND FTS USE, THE PROGRAM AIMS TO EMPOWER THEM TO INTERVENE EFFECTIVELY IN OPIOID-RELATED EMERGENCIES AND REDUCE ASSOCIATED HARM. THE OVERARCHING GOALS OF THIS PROJECT ARE TO EXPAND ACCESS TO NALOXONE AND FTS AMONG STUDENTS AT THE UNIVERSITY OF MISSISSIPPI AND HIGH SCHOOLS IN NORTHERN MISSISSIPPI, AND TO EMPOWER STUDENTS WITH THE KNOWLEDGE, SKILLS, AND RESOURCES TO RECOGNIZE OPIOID OVERDOSE SYMPTOMS, ADMINISTER NALOXONE EFFECTIVELY, AND MAKE INFORMED DECISIONS REGARDING DRUG USE THROUGH FENTANYL TESTING. KEY OBJECTIVES INCLUDE DEVELOPING PARTNERSHIPS WITH STUDENT ORGANIZATIONS, SCHOOL DISTRICTS, AND LOCAL STAKEHOLDERS TO COORDINATE TRAINING PROGRAMS; DISSEMINATING EDUCATIONAL MATERIALS TO RAISE AWARENESS AND REDUCE STIGMA; AND DISTRIBUTING NALOXONE KITS AND FTS TO STUDENTS, ACCOMPANIED BY COMPREHENSIVE COUNSELING ON USAGE AND STORAGE. THROUGH THESE EFFORTS, THE PROJECT SEEKS TO REACH APPROXIMATELY 10% OF THE UNIVERSITY OF MISSISSIPPI STUDENT POPULATION (AROUND 2,000 STUDENTS) AND AN ESTIMATED 24,000 HIGH SCHOOL STUDENTS ACROSS NORTHERN MISSISSIPPI. WRITTEN CONSENT WILL BE OBTAINED FOR ALL PARTICIPANTS TO ENSURE TRANSPARENCY AND COMMUNITY INVOLVEMENT IN PROGRAM IMPLEMENTATION. CONTINUOUS EVALUATION AND STAKEHOLDER FEEDBACK WILL INFORM PROGRAM ENHANCEMENTS, FOSTERING A SUSTAINABLE APPROACH TO OPIOID HARM REDUCTION IN EDUCATIONAL SETTINGS. BY EXPANDING ACCESS TO NALOXONE AND FTS AND EMPOWERING STUDENTS WITH LIFE-SAVING SKILLS, THIS INITIATIVE STRIVES TO MITIGATE THE IMPACT OF OPIOID MISUSE AND ENHANCE COMMUNITY RESILIENCE AGAINST DRUG-RELATED EMERGENCIES IN NORTHERN MISSISSIPPI.

BOTANICAL DIETARY SUPPLEMENT RESEARCH

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER (UMMC), WHICH SERVES AS THE STATE’S ONLY LEVEL I TRAUMA CENTER AS WELL AS THE STATE’S ONLY CHILDREN’S HOSPITAL, IS THE EPICENTER OF EMERGENCY CARE FOR THE STATE OF MISSISSIPPI, INCLUDING EMERGENCY CARE PROVIDED TO AN INCREASING NUMBER OF PATIENTS IN ACUTE PSYCHIATRIC DISTRESS. SEVERAL HOSPITALS IN THE JACKSON METRO AREA AND ACROSS THE STATE ARE LIMITING PSYCHIATRIC SERVICES AND/OR CLOSING INPATIENT PSYCHIATRIC BEDS, FORCING PATIENTS TO SEEK CARE ELSEWHERE AND FUNNELING MANY OF THEM TO UMMC. IN PARTICULAR, IN 2023, A LARGE HOSPITAL IN THE LOCAL JACKSON AREA DISCONTINUED ITS BEHAVIORAL HEALTH SERVICES, RESULTING IN THE LOSS OF 83 INPATIENT AND GERIATRIC PSYCHIATRY BEDS FOR THE REGION. CONSEQUENTLY, PATIENTS SEEKING CARE AT UMMC’S ADULT EMERGENCY DEPARTMENT (AED) EXPERIENCE LONG WAIT TIMES DUE TO LACK OF AVAILABILITY OF PATIENT ROOMS. THIS IS A PARTICULARLY CHALLENGING SCENARIO, GIVEN THE INCREASING NUMBERS OF PATIENTS EXPERIENCING MENTAL HEALTH CRISES AND IN NEED OF IMMEDIATE MEDICAL ATTENTION AND INTERVENTION. THROUGH THIS PROJECT, UMMC PLANS TO REDESIGN, DEMOLISH, AND RENOVATE PORTIONS OF ITS EXISTING ACUTE SERVICES WING AND SOUTH WING ON THE MEDICAL CENTER’S MAIN CAMPUS IN JACKSON, MISSISSIPPI, TO ALLOW FOR THE CONSTRUCTION OF A DEDICATED PSYCHIATRIC EMERGENCY SERVICES (PES) UNIT CAPABLE OF TREATING BOTH ADULT AND ADOLESCENT PATIENTS. UMMC SEEKS $3,200,000 IN FUNDING THROUGH HRSA’S COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING PROGRAM TO HELP COVER THE DEMOLITION AND RENOVATION COSTS OF THE PROJECT. FUNDS REQUESTED THROUGH THIS PROGRAM WILL ALSO GO TOWARDS EQUIPPING THE NEWLY REDESIGNED EMERGENCY CARE AREAS. IN ADDITION TO $3,200,000 IN FUNDS BEING SOUGHT THROUGH THIS APPLICATION, THIS PROJECT IS ALSO BEING FUNDED IN PART BY $3,000,000 IN INTERNALLY DESIGNATED UMMC FUNDS OVER THE COURSE OF THE PROJECT TIMELINE. THIS PROJECT WILL HELP UMMC EMERGENCY CARE TEAMS PROVIDE IMMEDIA TE CARE TO INDIVIDUALS EXPERIENCING ACUTE MENTAL HEALTH CRISES, INCLUDING SEVERE DEPRESSION, SUICIDAL IDEATION, ACUTE ANXIETY, PSYCHOSIS, SUBSTANCE USE ISSUES, AND OTHER CONDITIONS REQUIRING URGENT PSYCHIATRIC INTERVENTION. THIS PROJECT WILL ALSO PROVIDE A SAFER CARE ENVIRONMENT FOR NON-PSYCHIATRIC PATIENTS BEING TREATED IN THE AED.

THE ROLE OF POU4F3 IN AGE-RELATED VESTIBULAR DYSFUNCTION - PROJECT SUMMARY: IT HAS BEEN ESTIMATED THAT MORE THAN 40% OF OLDER ADULTS SUFFER VESTIBULAR (I.E. BALANCE) DEFICITS. THESE LOSSES CAUSE NUMEROUS OTHER PROBLEMS ASSOCIATED WITH AGING INCLUDING COGNITIVE DECLINE AND INJURIOUS OR FATAL FALLS. THERE IS ALSO A STRONG LINK BETWEEN AGE-RELATED VESTIBULAR DYSFUNCTION (ARVD) AND ALZHEIMER'S DISEASE AND RELATED DEMENTIAS. DESPITE THE PREVALENCE OF THESE ISSUES AND THE MASSIVE TOLL THEY EXERT ON PUBLIC HEALTH AND ASSOCIATED FINANCIAL COSTS, THE UNDERLYING CAUSES FOR ARVD ARE POORLY UNDERSTOOD. AS A RESULT, THERE ARE CURRENTLY NO FDA APPROVED THERAPIES FOR ARVD. WHILE A DEEP UNDERSTANDING OF MECHANISTIC CAUSES IS LACKING, IT HAS BEEN KNOWN FOR SOME TIME THAT A VERY COMMON PATHOLOGY THAT CAUSES AGE RELATED INNER EAR DYSFUNCTION IS THE DEATH OF SENSORY CELLS CALLED HAIR CELLS. EXACTLY WHY THESE CELLS DIE WITH AGE REMAINS A MYSTERY. HERE, WE HAVE IDENTIFIED A PREVIOUSLY UNCHARACTERIZED PATTERN IN THE EXPRESSION OF THE PRO-SURVIVAL GENE, POU4F3, WHERE IT IS NORMALLY HIGHLY EXPRESSED IN INNER EAR HAIR CELLS, BUT IS DOWNREGULATED WITH AGE IN A FASHION THAT IS CORRELATED WITH HAIR CELL DEATH IN THE BALANCE ORGANS OF THE INNER EAR. FURTHERMORE, PRELIMINARY DATA SUGGEST THAT DELETING POU4F3 CAUSES DETRIMENTAL PHENOTYPES IN VESTIBULAR HAIR CELLS, EXACERBATES HAIR CELL DEATH, AND LEADS TO SIGNIFICANT DECLINES IN VESTIBULAR FUNCTION. WE PROPOSE TO BUILD ON THESE PRELIMINARY DATA BY FURTHER EXAMINING POU4F3 CHANGES IN EXPRESSION IN VESTIBULAR ORGANS WITH AGE AND IN MODELS OF ALZHEIMER'S DISEASE. WE WILL ALSO MORE THOROUGHLY CHARACTERIZE THE EFFECTS OF POU4F3 DELETION TO BETTER UNDERSTAND THE EFFECTS THAT DELETION OR HYPOMORHPISM HAVE ON BALANCE AND NEUROLOGICAL FUNCTIONS. WE ALSO PROPOSE TO EXAMINE GENOMIC REGULATORY ELEMENTS IN INNER EAR TISSUES FROM YOUNG AND AGED MICE TO IDENTIFY CAUSAL MECHANISMS FOR POU4F3 DOWNREGULATION WITH AGE AS WELL AS POSSIBLY DISCOVER OTHER KEY GENES INVOLVED IN AGING PROCESSES IN THE INNER EAR. FINALLY, WE WILL TEST WHETHER OVEREXPRESSION OF POU4F3 CAN PREVENT SENSORY CELL DEATH AND AGE RELATED VESTIBULAR DECLINES. OUR PRELIMINARY DATA SUGGEST THAT POU4F3 IS A PROMISING THERAPEUTIC TARGET FOR PRESERVING BALANCE FUNCTION IN THE AGING HUMAN POPULATION. THE EXPERIMENTS PROPOSED WILL DETERMINE THE VALIDITY OF THAT OVERARCHING HYPOTHESIS AND WILL PROVIDE A FOUNDATION FROM WHICH TO LAUNCH SEVERAL NEW INVESTIGATIONS INTO POU4F3-TARGETED PHARMACOLOGICAL AND GENE THERAPY APPROACHES FOR THE PREVENTION OF AGE RELATED VESTIBULAR DECLINE.

MISSISSIPPI CANCER REGISTRY - NPCR

THE KIDNEY, HYPERTENSION, PREGNANCY AND INFLAMMATION

PROMOTING RESILIENCE AND MENTAL HEALTH AMONG HEALTH PROFESSIONAL WORKFORCE

IMPACT OF SOCIAL FACTORS ON BREAST CANCER BIOLOGY IN AFRICAN-AMERICAN WOMEN

AGEP: ALLIANCE FOR GRADUATE EDUCATION IN MISSISSIPPI

MECHANISMS OF BLAST-INDUCED VESTIBULAR INJURY

UNIVERSITY OF MISSISSIPPI FY 23 CONGRESSIONAL COMMUNITY PROJECT FUNDING

UNIVERSITY OF MISSISSIPPI FY 09 EARMARK ENTITLED FOR REMOTE SENSING GEOSPATIAL SPACE AND AVIA

L-CARNITINE TREATMENT FOR VASOPRESSOR DEPENDENT SEPTIC SHOCK

SCIENCE BASED AUTHENTICATION OF DIETARY SUPPLEMENTS

SLEEP-DISORDERED BREATHING AND RISK FOR CVD AND STROKE IN THE JACKSON HEART STUDY

MULTIMODAL NONDESTRUCTIVE DRY CASK BASKET STRUCTURE AND SPENT FUEL EVALUATION

PURPOSE: THE PROJECT FUNDS WILL SUPPORT THE PROCUREMENT OF FURNISHINGS AND EQUIPMENT RELATED TO CANCER RESEARCH FOR THE TRANSLATIONAL RESEARCH CENTER (TRC) BUILDING ON THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER (UMMC) CAMPUS IN JACKSON, MS. ACTIVITIES TO BE PERFORMED: THE PROJECT CONSISTS OF FURNISHING AND EQUIPPING APPROXIMATELY 7,625 SQUARE FEET OF EXISTING SPACE FOR CANCER RESEARCH LABORATORIES, SUPPORT SPACE AND INFRASTRUCTURE IN THE TRC. THE BUDGET FOR THIS PROJECT IS $2.8M WHICH INCLUDES $2.75M IN EQUIPMENT AND $50,000 IN FURNISHINGS. UMMC IS CURRENTLY IN THE PLANNING PROCESS FOR EQUIPMENT SELECTION AND HAS BASED THE CURRENT BUDGET ON MARKET RESEARCH. A FINAL LIST OF EQUIPMENT WITH VENDOR QUOTES WILL BE SUBMITTED LATER. ONCE EQUIPMENT DECISIONS HAVE BEEN MADE UMMC WILL SEEK APPROVAL FROM UMMC'S SHARED GOVERNING BOARD, THE INSTITUTIONS OF HIGHER LEARNING AS WELL AS ADHERING TO OTHER INTERNAL AND STATE PROCUREMENT REQUIREMENTS. EXPECTED OUTCOMES: THE EQUIPMENT WILL SUPPORT GROWTH OF THE CCRI WITH THE ULTIMATE GOAL FOR UMMC TO APPLY FOR NATIONAL CENTER INSTITUTE DESIGNATION IN 10 YEARS. WITH UMMC'S GOAL TO RECRUIT 30 NEW CANCERRESEARCH FACULTY, THIS PROJECT WILL PROVIDE MODERN LAB AND SUPPORT SPACE FOR UP TO EIGHT RESEARCH FACULTY, PLUS THEIR SUPPORT STAFF. INTENDED BENEFICIARIES: EXPANDING AND MODERNIZING THE CURRENT RESEARCH SPACE TO SUPPORT UMMC'S CANCER RESEARCH FACULTY IS A CRITICAL COMMITMENT TO BRING CUTTING EDGE CANCER CARE TO MISSISSIPPIANS, AS THERE IS CURRENTLY NOT A NCI-DESIGNATED CANCER CENTER IN MISSISSIPPI, LUISIANA, OR ARKANSAS. THIS PROJECT WILL HELP FACILITATE THAT DESIGNATION AND WILL IMPROVE CANCER RESEARCH, PATIENT CARE, AND MEDICAL OUTCOMES FOR THE REGION'S CANCER PATIENTS. SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

DISCRETIONARY

20-HETE-TGF-BETA IN HYPERTENSION-INDUCED RENAL INJURY

DEVELOPMENT OF SAFER DRUGS FOR MALARIA IN U.S. TROOPS, CIVILIAN PERSONNEL, AND TRAVELERS: CLINICAL EVALUATION OF PRIMAQUINE ENANTIOMERS

COMMUNITY BASED DENTAL PARTNERSHIP

"PROPOSAL TITLE: THE NATIONAL CENTER FOR REMOTE SENSING AIR AND SPACE LAW"THIS IS A PROPOSAL TO EXT

INTENSITY FRONTIER STUDIES AT THE UNIVERSITY OF MISSISSIPPI

REGULATION OF VASCULAR MATURATION/REGRESSION IN DIABETES

BALANCE AND AUDITORY RESEARCH CENTER (BARC) - PROJECT SUMMARY FOR THE BALANCE AND AUDITORY RESEARCH CENTER (BARC) VESTIBULAR AND AUDITORY FUNCTIONS ARE FUNDAMENTAL TO SURVIVAL AND QUALITY OF LIFE. CHILDHOOD HEARING LOSS IS THE MOST COMMON CONGENITAL DISORDER, ESTIMATED TO AFFECT 2-3 IN EVERY 1000 BIRTHS, AND OFTEN CO-MORBID WITH VESTIBULAR IMPAIRMENT. BALANCE IMPAIRMENT AND FALLS ARE AMONG THE MOST PREVALENT AND MORBID CONDITIONS AFFECTING OLDER ADULTS, THE MOST COMMON CAUSE OF TRAUMATIC BRAIN INJURY. HEARING LOSS IS THE THIRD MOST COMMON CHRONIC HEALTH CONDITION AND ONE OF THE STRONGEST MODIFIABLE RISK FACTORS FOR COGNITIVE DECLINE AND DEMENTIA. THE REPERCUSSIONS OF BALANCE AND HEARING DISORDERS FOR MORTALITY AND MORBIDITY ARE JUST NOW REACHING A NEW LEVEL OF RECOGNITION. YET, BALANCE AND HEARING ARE LARGELY UNINVESTED AREAS OF NEUROSCIENCE, WHICH HAS CONTRIBUTED TO THE LACK OF TRANSLATION OF MEDICAL INTERVENTIONS FOR BALANCE AND HEARING DISORDERS. UNDERSTANDING THE GENETIC, STRUCTURAL, AND NEUROPHYSIOLOGICAL MECHANISMS UNDERLYING BALANCE AND HEARING DISORDERS IS ESSENTIAL FOR DEVELOPING INNOVATIVE DIAGNOSTIC TOOLS, THERAPEUTIC STRATEGIES, AND REHABILITATION TECHNIQUES FOR PATIENTS. THE GOAL OF ESTABLISHING THE BALANCE AND AUDITORY RESEARCH CENTER (BARC) AT THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER (UMMC) IS TO BUILD A CRITICAL MASS OF INDEPENDENT INVESTIGATORS TO DEVELOP EFFECTIVE DIAGNOSTIC AND THERAPEUTICS FOR BALANCE AND AUDITORY DISORDERS. BARC WILL BE BUILT UPON A SOLID CORE OF WELL-SUPPORTED AND ESTABLISHED NEUROSCIENTISTS IN VESTIBULAR AND AUDITORY RESEARCH. BARC HAS THREE SPECIFIC AIMS: (1) FOSTER A RESEARCH ENVIRONMENT THAT SUPPORTS COLLABORATIVE AND INNOVATIVE VESTIBULAR AND AUDITORY NEUROSCIENCE RESEARCH; (2) DEVELOP RESEARCH CAPACITY TO CONDUCT STATE-OF-THE-ART VESTIBULAR AND AUDITORY NEUROSCIENCE RESEARCH THROUGH DEVELOPMENT OF TWO RESEARCH CORES AND ADDITIONAL FACULTY POSITIONS: AND (3) NURTURE A GROUP OF EARLY STAGE AND NEW INVESTIGATORS TO BECOME INDEPENDENT RESEARCHERS IN THE FIELD OF VESTIBULAR AND AUDITORY RESEARCH.

NATIONAL SEA GRANT LAW CENTER: 2018 - 2021 OMNIBUS PROPOSAL

TELEHEALTH CENTER OF EXCELLENCE

BENZODIAZEPINE CHOICE AND POLYDRUG USE - PROJECT SUMMARY BENZODIAZEPINES (BZS) ARE EFFECTIVE AND SAFE WHEN USED APPROPRIATELY, BUT THEIR UTILITY IS LIMITED BY UNWANTED SIDE EFFECTS LIKE MISUSE AND REDUCED SAFETY WHEN COMBINED WITH OTHER DRUGS. INDIVIDUALS WITH SUBSTANCE-USE DISORDERS (SUDS) MISUSE BZS AS MUCH AS 20X GREATER THAN THE GENERAL POPULATION, AND THE RISING NUMBER OF OVERDOSE DEATHS ATTRIBUTED TO BZS ARE LARGELY DRIVEN BY OPIOID CO-ADMINISTRATION. GIVEN THE HIGH RATES OF POLYDRUG USE AMONG INDIVIDUALS WHO ALSO MISUSE BZS, PRECLINICAL EVALUATIONS OF BZS SHOULD CONSIDER THE POLYDRUG SCENARIOS IN WHICH THEY ARE BEING MISUSED. THE GOAL OF THIS RESEARCH IS TO IDENTIFY PHARMACOLOGICAL DETERMINANTS OF BZ MISUSE, WITH THE GOAL OF IDENTIFYING BZ-TYPE LIGANDS WITH REDUCED ABUSE POTENTIAL IN POLYDRUG SITUATIONS. WE REPORTED PREVIOUSLY THAT NONSELECTIVE, PARTIAL-EFFICACY BZ LIGANDS OR THOSE THAT LACK INTRINSIC EFFICACY AT A1- SUBUNIT CONTAINING GABAA (A1GABAA) RECEPTORS HAVE REDUCED ABUSE POTENTIAL RELATIVE TO TRADITIONAL BZS. HOWEVER, OUR DATA SUGGEST THAT THE DEGREE TO WHICH THESE BZ-TYPE LIGANDS EXHIBIT ABUSE POTENTIAL DEPENDS ON THE SUBJECT’S DRUG HISTORY. THIS NEW APPLICATION WILL USE CHOICE MODELS TO EVALUATE THE OVERALL HYPOTHESIS THAT DRUG EXPERIENCE IS A KEY DETERMINANT OF THE ROLE OF GABAA RECEPTOR SUBTYPES IN THE ABUSE POTENTIAL OF BZ-TYPE LIGANDS. A KEY FINDING FROM OUR CHOICE RESEARCH IS THAT EFFICACY AT A1GABAA RECEPTORS MAY BE NECESSARY FOR SELF- ADMINISTRATION OF BZS IN COCAINE-EXPERIENCED SUBJECTS, BUT NOT REQUIRED FOR ENHANCEMENT OF COCAINE CHOICE. IT IS UNKNOWN WHETHER THIS PATTERN OF EFFECTS IS OBSERVED WITH OTHER DRUGS OF ABUSE, IN PARTICULAR OPIOIDS. MOREOVER, THE PHARMACOLOGICAL MECHANISM UNDERLYING THESE EFFECTS IS UNKNOWN, WITH POSSIBILITIES INCLUDING (1) A DIFFERENTIAL ROLE FOR A1GABAA RECEPTORS IN REINFORCEMENT-ENHANCING VS. REINFORCING EFFECTS OF BZS ALONE, OR (2) DIFFERENCES IN OVERALL INTRINSIC EFFICACY, IRRESPECTIVE OF SUBTYPE SELECTIVITY. WE WILL ADDRESS THESE POTENTIAL MECHANISMS IN TWO AIMS ORGANIZED BY UNIQUE APPROACHES. IN AIM 1, WE WILL USE DRUG VS. DRUG CHOICE TO EVALUATE THE EXTENT TO WHICH BZ-TYPE LIGANDS VARYING IN EFFICACY AND SELECTIVITY WILL ENHANCE OR ATTENUATE DRUG CHOICE WHEN DELIVERED AS A COMBINATION WITH COCAINE, HEROIN, OR ALPRAZOLAM IN SEPARATE GROUPS OF SUBJECTS. IN AIM 2, WE WILL USE DRUG VS. NONDRUG CHOICE TO EVALUATE THE HYPOTHESIS THAT NONSELECTIVE, PARTIAL MODULATORS OR A1-SPARING BZS WILL HAVE REDUCED REINFORCING EFFECTS WHEN DELIVERED ALONE IN SUBJECTS WITH A HISTORY OF COCAINE, HEROIN, ALPRAZOLAM, OR FOOD CHOICE. A SIGNIFICANT ADDITION TO OUR GROUPS OF MONKEYS WITH DIFFERENT REINFORCEMENT HISTORIES WILL BE THE FOOD-EXPERIENCED ANIMALS, PROVIDING A QUANTITATIVE MODEL OF DRUG-NAÏVE INDIVIDUALS’ INITIAL EXPOSURE TO DRUG TAKING. BZ USE AMONG INDIVIDUALS WITH A SUD, IN OR OUT OF TREATMENT, IS INCREASINGLY COMMON AND IS ASSOCIATED WITH INCREASED RISK OF BZ MISUSE AND OVERDOSE. TESTING THE HYPOTHESES PROPOSED WILL PROVIDE CRITICAL INFORMATION FOR UNDERSTANDING HOW PAST AND CURRENT DRUG USE AFFECTS THE ABUSE LIABILITY OF BZ-TYPE DRUGS.

RYAN WHITE TITLE IV WOMEN, INFANTS, CHILDREN, YOUTH AND AFFECTED FAMILY MEMBERS AIDS HEALTHCARE

NOVEL GABA-A MODULATORS AS COGNITIVE ENHANCERS

MISSISSIPPI -- BEHAVIORAL HEALTH IN INFANTS AND PRESCHOOLERS (MS-BE HIP)

GABAA RECEPTOR SUBTYPE MECHANISMS IN NONHUMAN PRIMATE MODELS OF ALCOHOL ABUSE

RESOURCE CENTER FOR CANNABIS AND CANNABINOID RESEARCH (R3CR) - PROJECT ABSTRACT CONDUCTING RESEARCH INVOLVING CANNABIS OR CANNABINOIDS PRESENTS MANY CHALLENGES TO SCIENTISTS REGARDING REGULATORY ISSUES AND THE ACQUISITION AND UTILIZATION OF MATERIALS SUITABLE FOR VALID SCIENTIFIC STUDIES. TO ADDRESS AND RECTIFY THE MAJOR BARRIERS AND CHALLENGES TO CANNABIS RESEARCH, WE WILL ESTABLISH A RESOURCE CENTER THAT WILL PROVIDE RESEARCH TOOLS TO THE SCIENTIFIC COMMUNITY THAT WILL ALLOW ADVANCES IN CANNABIS SCIENCE THROUGH BOTH NON- CLINICAL AND CLINICAL STUDIES. THE GOAL OF THIS CENTER IS TO SERVE AS A COMPREHENSIVE RESOURCE TO SUPPORT INVESTIGATORS INVOLVED OR INTERESTED IN CANNABIS RESEARCH BY PROVIDING GUIDANCE AND INFORMATION TO HELP ADDRESS BARRIERS AND CHALLENGES RELATED TO REGULATIONS, RESEARCH MATERIALS, AND PROPOSAL DEVELOPMENT. THE CENTER WILL CONSIST OF THREE CORES THAT WILL PROVIDE GUIDANCE THROUGH A CENTRALIZED WEBSITE AS WELL AS THROUGH WORKSHOPS AND WEBINARS. THE RESEARCH SUPPORT CORE WILL DISSEMINATE SCIENTIFIC AND REGULATORY INFORMATION, ORGANIZE, AND CONVENE WEBINARS AND WORKSHOPS, AND ADMINISTER SEED FUNDING FOR REGISTRATION SUPPORT AND PROPOSAL DEVELOPMENT. THE SCORING CRITERIA FOR SEED FUNDING AWARD APPLICATIONS WILL INCLUDE RELEVANCE TO THE INTERESTS OF THE NIH IC SPONSORS. THE REGULATORY GUIDANCE CORE WILL ESTABLISH A CLEARINGHOUSE FOR POLICY GUIDANCE. THE RESEARCH STANDARDS CORE WILL PROVIDE GUIDANCE ON CANNABIS RESEARCH THROUGH A REPOSITORY OF BEST PRACTICES AND TECHNICAL INFORMATION. THE CENTER WILL IMPACT A BROAD RANGE OF STAKEHOLDERS, INCLUDING THE SCIENTIFIC COMMUNITY, FEDERAL AND STATE AGENCIES, INSTITUTIONAL ADMINISTRATORS, AND SUPPLIERS OF RESEARCH MATERIALS. NEW CANNABIS INVESTIGATIONS FOSTERED BY OUR GUIDANCE WILL SERVE AS INCENTIVES FOR OTHERS TO ENTER THE CANNABIS RESEARCH FIELD, WHICH MAY LEAD TO NOVEL RESEARCH STUDIES AND LICENSING OF MORE CANNABIS TECHNOLOGIES AS A CLEAR REGULATORY PATHWAY DEVELOPS. INVESTIGATORS AS WELL AS RESEARCH ADMINISTRATORS WILL UTILIZE OUR GUIDANCE TOOLS TO ADVANCE THEIR STUDIES BY GAINING AN IMPROVED UNDERSTANDING OF REGULATORY REQUIREMENTS AND BEST PRACTICES. THE GOALS AND OBJECTIVES OF THIS PROPOSAL WILL BE ACCOMPLISHED THROUGH THESE SPECIFIC AIMS: 1. PROMOTE WIDESPREAD ADVANCEMENT OF CANNABIS RESEARCH BY PROPAGATING GUIDANCE AND RESOURCES TO INVESTIGATORS. 2. REDUCE BARRIERS TO CANNABIS RESEARCH BY COMPILING AND INTERPRETING REGULATORY POLICIES TO BENEFIT BOTH THE INVESTIGATORS AND THE REGULATORY AGENCIES. 3. IMPROVE THE REPRODUCIBILITY OF RESEARCH STUDIES BY PROVIDING GUIDANCE ON INVESTIGATIONAL MATERIALS, QUALITY STANDARDS, PRACTICES, AND METRICS FOR QUALITY RESEARCH.

DEVELOPMENT OF SAFER DRUGS FOR MALARIA IN U.S. TROOPS, CIVILIAN PERSONNEL AND TRAVELERS"

NATIONAL CENTER FOR JUSTICE AND THE RULE OF LAW

DEVELOPMENT OF NATURAL PRODUCTS FROM PLANTS AND MICROBES FOR REPLACEMENT OF SYNTHETIC PESTICIDES

THIS IS A PROPOSAL TO EXTEND PREVIOUS SIGNIFICANT AND NUMEROUS ACCOMPLISHMENTS OF THE NATIONAL CENTER FOR REMOTE SENSING, AIR, AND SPACE LAW (CENTER)

DEVELOPMENT OF NATURAL PRODUCTS FROM PLANTS AND MICROBES FOR REPLACEMENT OF SYNTHETIC PESTICIDES

DEVELOPMENT OF NATURAL PRODUCTS FROM PLANTS AND MICROBES FOR REPLACEMENT OF SYNTHETIC PESTICIDES

NEUROSTEROID-BZ COMBINATIONS: STRATEGY FOR REDUCING ABUSE AND SEDATION

DESCRIPTION: “PURPOSE: RECIPIENTS OF THE STATE SMALL BUSINESS CREDIT INITIATIVE TECHNICAL ASSISTANCE GRANT PROGRAM (SSBCI TA GRANT PROGRAM), WHICH MAY INCLUDE STATES, THE DISTRICT OF COLUMBIA, TERRITORIES, AND TRIBAL GOVERNMENTS, WILL RECEIVE GRANTS TO PROVIDE TECHNICAL ASSISTANCE (I.E., LEGAL, ACCOUNTING, AND FINANCIAL ADVISORY SERVICES) TO SMALL BUSINESSES APPLYING FOR SSBCI CAPITAL PROGRAMS OR OTHER FEDERAL OR OTHER JURISDICTION PROGRAMS THAT SUPPORT SMALL BUSINESSES. ACTIVITIES TO BE PERFORMED/END GOAL/EXPECTED OUTCOMES: THE GOAL OF THESE GRANTS IS TO SUPPORT THE PROVISION OF TECHNICAL ASSISTANCE TO SMALL BUSINESSES APPLYING FOR SSBCI CAPITAL PROGRAMS OR OTHER FEDERAL OR OTHER JURISDICTION PROGRAMS THAT SUPPORT SMALL BUSINESSES. INTENDED BENEFICIARIES: QUALIFYING VERY SMALL AND UNDERSERVED SMALL BUSINESSES AS DESCRIBED IN THE SSBCI TA GRANT PROGRAM GUIDELINES. SUBRECIPIENT ACTIVITIES: SUBRECIPIENT ACTIVITIES ARE NOT KNOWN AT THIS TIME.

GABA-A RECEPTOR SUBTYPE MECHANISMS AND THE ABUSE-RELATED EFFECTS OF ALCOHOL

DIRECTED GRANTS

DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCTS FOR PHARMACEUTICAL AND AGRICHEMICAL APPLICATIONS

DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCTS FOR PHARMACEUTICAL AND AGRICHEMICAL APPLICATIONS

IDENTIFYING NOVEL BIOLOGICAL PATHWAYS FOR GOUT USING DNA METHYLATION AND GENETICS

DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCTS FOR PHARMACEUTICAL AND AGRICHEMICAL APPLICATIONS

BLAST AND IMPACT RESISTANT COMPOSITE STRUCTURES FOR NAVY SHIPS

CARDIAC PROTECTIVE MECHANISMS OF MELANOCORTIN SYSTEM ACTIVATION - PROJECT SUMMARY/ABSTRACT OVER 1.5 MILLION AMERICANS SUFFER FROM MYOCARDIAL INFARCTION (MI) EACH YEAR, AND ABOUT 25% OF THESE PATIENTS DEVELOP SEVERE CARDIAC DYSFUNCTION INCLUDING CONGESTIVE HEART FAILURE (HF), WHICH HAS A HIGH 5-YEAR MORTALITY RATE OF ~50%. CURRENT THERAPIES FOLLOWING MI HAVE LIMITED SUCCESS IN ATTENUATING CARDIAC DYSFUNCTION AND SLOWING HF PROGRESSION. THUS, THERE IS A CRITICAL NEED FOR NOVEL, MORE EFFECTIVE THERAPIES THAT PROTECT THE HEART, IMPROVE ITS FUNCTION, AND SLOW/HALT PROGRESSION OF CARDIAC DYSFUNCTION. WE RECENTLY DEMONSTRATED THAT ACTIVATION OF THE BRAIN LEPTIN-MELANOCORTIN SYSTEM PATHWAY GREATLY IMPROVES CARDIOMYOCYTE ENERGY METABOLISM AND CONTRACTILITY, PRESERVES CARDIAC FUNCTION, AND PREVENTS PROGRESSION OF HF FOLLOWING MI INDUCED BY LIGATION OF THE LEFT ANTERIOR DESCENDING CORONARY ARTERY. WE OBSERVED THAT INTRACEREBROVENTRICULAR (ICV) INFUSION OF LEPTIN FOR 4 WEEKS, AT A LOW DOSE THAT DID NOT ALTER BLOOD LEPTIN CONCENTRATION, RESTORED EJECTION FRACTION, CARDIAC OUTPUT, LEFT VENTRICLE (LV) MUSCLE STRAIN AND LEFT ATRIUM/AORTA DIAMETER RATIO ALMOST ALL THE WAY BACK TO NORMAL BASELINE VALUES, AND PRELIMINARY DATA SUGGEST THAT OTHER MEASURES OF CARDIAC FUNCTION SUCH AS +DP/DTMAX AND EXERCISE CAPACITY WERE ALSO MARKEDLY IMPROVED. WE ALSO OBSERVED THAT THESE CARDIAC PROTECTIVE EFFECTS ARE ABSENT IN MELANOCORTIN 4 RECEPTOR (MC4R) DEFICIENT RATS AND THAT ACTIVATION OF BRAIN MC4R USING SYNTHETIC AGONISTS INFUSED INTO THE CEREBRAL VENTRICLES PROTECTED THE HEART AGAINST PROGRESSIVE CARDIAC DYSFUNCTION AFTER MI IN A SIMILAR FASHION COMPARED TO LEPTIN TREATMENT. OUR PRELIMINARY DATA ALSO INDICATE THAT ACTIVATION OF THE CNS LEPTIN-MC4R PATHWAY INCREASES SIRTUIN-3 (SIRT3) EXPRESSION, MITOCHONDRIAL BIOGENESIS AND SUBSTRATE OXIDATION (I.E., GLUCOSE AND FATTY ACID OXIDATION), AND IMPROVES CARDIOMYOCYTE CONTRACTILITY IN NON-INFARCTED REGIONS OF THE LV, INCLUDING AREAS AT RISK BUT STILL VIABLE. THE CENTRAL HYPOTHESIS OF THIS PROPOSAL IS THAT ACTIVATION OF THE BRAIN MELANOCORTIN SYSTEM IMPROVES CARDIAC FUNCTION AND PREVENTS PROGRESSION OF HF AFTER MI, INCREASES MYOCARDIUM MITOCHONDRIAL BIOGENESIS AND SIRT3 LEVELS, ENHANCES SUBSTRATE OXIDATION, AND IMPROVES ENERGY PRODUCTION AND CARDIOMYOCYTE CONTRACTILITY IN HEALTHY PORTIONS OF THE HEART. WE ALSO PROPOSE THAT THESE BENEFICIAL EFFECTS OF THE MELANOCORTIN SYSTEM ON THE HEART REQUIRE MC4R ACTIVATION IN PVN AND/OR DMV/NTS/IML, AND THAT MC4R AGONISTS THAT CROSS THE BLOOD-BRAIN BARRIER (E.G. SETMELANOTIDE) AND CAN BE ADMINISTERED SYSTEMICALLY WILL BE EFFECTIVE TO PROVIDE CARDIOPROTECTIVE EVEN IN THE SETTING OF OBESITY. WE WILL USE STATE-OF-THE-ART CHRONIC IN VIVO PROTOCOLS WITH HIGH-RESOLUTION ULTRASOUND TECHNIQUES FOR IMAGING CARDIAC FUNCTION (INCLUDING 4D-STRAIN ECHOCARDIOGRAPHIC IMAGING TECHNOLOGY) IN GENETICALLY ENGINEERED ANIMAL MODELS COMBINED WITH EX VIVO AND IN VITRO PREPARATIONS FOR DETAILED MEASUREMENTS OF CARDIAC MUSCLE FUNCTION, MORPHOLOGY, ENERGY METABOLISM AND CONTRACTILITY TO TEST OUR HYPOTHESES. THE OUTCOMES FROM THIS STUDY COULD LEAD TO NOVEL AND MORE EFFECTIVE THERAPEUTIC APPROACHES FOR MI AND HF, AND WILL PROVIDE A NEW TARGET FOR MC4R AGONISTS WHICH ARE CURRENTLY BEING USED TO TREAT RARE FORMS OF GENETIC OBESITY IN HUMANS.

MECHANISM OF? PD1 ON CARDIAC INFLAMMATION RESOLUTION DURING HEART FAILURE DEVELOPMENT - CARDIOVASCULAR INFLAMMATION PROMOTES HEART FAILURE (HF) DEVELOPMENT. HOWEVER, MECHANISM OF CARDIAC INFLAMMATION RESOLUTION DURING HF DEVELOPMENT IS STILL POORLY UNDERSTOOD. PROGRAMMED CELL DEATH PROTEIN 1 (PD1) IS A PROTEIN THAT KEEPS THE BODY’S IMMUNE RESPONSES IN CHECK, BOTH BY INHIBITING INITIAL T CELL INDUCTION AND BY MAINTAINING T CELL TOLERANCE. PD1 BLOCKING ANTIBODIES ARE USED IN CANCER TREATMENT, BUT THE TREATMENT ALSO LEADS TO CARDIAC TOXICITY IN SOME PATIENTS. WE FOUND THAT PD1 KO OR PD1 BLOCKING ANTIBODIES DRAMATICALLY EXACERBATED TRANSVERSE AORTIC CONSTRICTION (TAC)-INDUCED CARDIAC INFLAMMATION, HF, AND DEATH, INDICATING PD1 EXERTS A MORE IMPORTANT ROLE UNDER STRESS CONDITIONS. TO UNDERSTAND MECHANISMS OF PD1 INHIBITION IN CARDIAC INFLAMMATION, WE STUDIED CARDIAC IMMUNE CELLS AND VASCULAR ENDOTHELIAL CELLS FROM WILD TYPE AND PD1 KO MICE AFTER SHAM OR TAC BY USING SINGLE-CELL CITE-SEQ TOGETHER WITH BARCODED ANTIBODIES FOR MEMBRANE PROTEIN LABELING. USING SINGLE-CELL CITE-SEQ, WE ALSO STUDIED LUNG IMMUNE CELLS FROM HF MICE AND SHAM MICE. BIOINFORMATICS ANALYSES HAVE PROVIDED ENORMOUSLY INFORMATION OF THESE CELLS – SHOWING DRAMATIC ALTERATIONS OF CELL CLUSTERS, ENRICHED PATHWAYS OF INNATE & ADAPTIVE IMMUNE RESPONSES, AND CHANGES OF METABOLIC PATHWAYS IN VARIOUS IMMUNE CELL SUBSETS IN HF MICE, OR IN PD1 KO AFTER TAC. GDT CELLS (A SUBSET OF T CELLS) CAN BE DIVIDED INTO EITHER IL-17 (GDT17) OR IFNG PRODUCERS. CITE-SEQ OF LUNG IMMUNE CELLS SHOWED THAT HF CAUSED DRAMATIC CHANGES OF VARIOUS T CELL AND MACROPHAGE CLUSTERS, A DRAMATIC INCREASE OF PD1 IN TH17 AND GDT17 CELLS, SUGGESTING PD1 EXERTS AN IMPORTANT ROLE IN SUPPRESSING TH17, AND GDT17 CELLS AS WELL AS HF PROGRESSION. CITE-SEQ IN CARDIAC IMMUNE CELLS SHOWED THAT INFILTRATION OF CD8+ T CELLS AND GDT CELLS INCREASED IN PD1 KO MICE AFTER TAC, AND THESE INFILTRATED CELLS ARE IFNG+ CELLS, INDICATING THAT CD8+ T CELLS, GDT CELLS, AND IFNG MAY CONTRIBUTE TO THE EXACERBATED CARDIAC INFLAMMATION IN PD1 KO MICE. BASED ON THESE EXCITING FINDINGS, WE HYPOTHESIZE THAT TAC-INDUCED CARDIAC AND PULMONARY INFLAMMATION RESOLUTION IS REGULATED BY PD1 THROUGH BOTH CONSERVED AND UNIQUE PATHWAYS AT LEAST PARTIALLY CONTROLLED BY IFNG AND IL17 PRODUCED BY CD8+ T CELLS, GDT CELLS, AND TH17, RESPECTIVELY. TO ENHANCE THE INNOVATIVE RIGOR OF OUR INVESTIGATION OF THE ROLE OF PD1 IN CARDIAC INFLAMMATION AND HF, WE WILL ALSO STUDY CD8 CELL SPECIFIC PD1 KO MICE. AIM-1. TEST THE HYPOTHESIS THAT IFNG AND CD8+ T CELLS CONTRIBUTE TO THE EXACERBATED CARDIAC INFLAMMATION, CYTOKINE STORM, AND HF IN PD1 KO AFTER TAC. IN ADDITON, WE WILL DETERMINE WHETHER PD1 KO IN CD8+ T CELLS IS SUFFICIENT TO EXACERBATE TAC-INDUCED CARDIAC INFLAMMATION AND HF. AIM-2. DETERMINE THE ROLES AND UNDERLYING MECHANISMS OF IL17 AND GDT CELLS IN PROMOTING TAC-INDUCED CARDIAC INFLAMMATION AND HF AFTER PD1 INHIBITION. THIS APPLICATION IS HIGHLY RESPONSIVE TO THE NOTICE OF SPECIAL INTEREST NOT-ES-20-018 AS THE PROPOSED STUDIES WILL ADVANCE OUR UNDERSTANDING OF THE MECHANISMS OF PD1 AND T CELLS IN CARDIAC AND LUNG INFLAMMATION RESOLUTION, AND THE CONSERVED & UNIQUE CHANGES IN CARDIAC AND LUNG IMMUNE CELL CLUSTERS DURING HF DEVELOPMENT AND PROGRESSION.

IMPROVE EXISTING AIRPORT C

MOBILITY DECLINE: RELATIONS TO CEREBRAL PERFUSION, SMALL VESSEL DISEASE PROGRESSION, AND LONGITUDINAL BLOOD PRESSURE EXPOSURES

ROLE OF MINERALOCORTICOIDS IN HYPERTENSION

SHORT SLEEP DURATION AS A PREDICTOR OF METHAMPHETAMINE INTAKE: ROLE OF OREXIN MECHANISMS - PROJECT SUMMARY_________________________________________________________________________ INSUFFICIENT SLEEP PREDICTS SUBSTANCE USE AND ASSOCIATED PSYCHOSOCIAL PROBLEMS, AND PUTS INDIVIDUALS AT A HIGHER RISK FOR SUBSTANCE USE DISORDERS. IN FACT, OUR PRELIMINARY DATA SUGGEST THAT THE QUALITY OF OVERALL BASELINE SLEEP MAY INFLUENCE METHAMPHETAMINE INTAKE IN RHESUS MONKEYS. THESE FINDINGS RAISE THE IMPORTANT POSSIBILITY THAT SHORT SLEEP INCREASES THE PROBABILITY OF ENHANCED METHAMPHETAMINE USE AND/OR USE DISORDER. WE RECENTLY DIS- COVERED THAT SHORT SLEEP IS A STRIKINGLY PREVALENT PHENOTYPE AMONG ADULT FEMALE RHESUS MONKEYS, WITH A PREVA- LENCE OF NEARLY 40%. WHILE THE BIOLOGICAL FACTORS CONTRIBUTING TO THIS PARTICULAR PHENOTYPE REMAIN UNKNOWN, AL- TERED CIRCADIAN RHYTHM OF OREXIN (HYPOCRETIN) REGULATION HAS BEEN PROPOSED AS A KEY MEDIATOR OF SHORT SLEEP (INSOMNIA) IN HUMANS, AND OUR STUDIES SUGGEST THAT THE OREXIN SYSTEM IS INVOLVED IN THE SHORT SLEEP PHENOTYPE IN FEMALE MONKEYS. MOREOVER, OUR RECENT RESEARCH ALSO HAS IMPLICATED THE OREXIN SYSTEM AS A POTENTIAL MODU- LATOR OF BOTH THE SLEEP IMPAIRING AND REINFORCING EFFECTS OF METHAMPHETAMINE, SUGGESTING AN IMPORTANT MECHA- NISTIC LINK BETWEEN SLEEP REGULATION AND METHAMPHETAMINE PHARMACOLOGY. BASED ON THESE OBSERVATIONS, THE WORKING HYPOTHESIS OF THIS APPLICATION IS THAT DYSREGULATION OF OREXIN PROCESSES AND SPECIFIC OREXIN RECEPTOR SUBTYPES PLAY A KEY ROLE IN PHENOTYPIC SHORT SLEEP IN FEMALE MONKEYS THAT, IN TURN, INCREASES VULNERABILITY TO THE ADDICTIVE PROPERTIES OF METHAMPHETAMINE. OUR RESEARCH STRATEGY IS ORGANIZED AROUND THREE SPECIFIC AIMS, AND ALL EXPERIMENTS WILL BE CONDUCTED IN FEMALE SHORT SLEEPERS AND FEMALE NORMAL SLEEPERS. AIM 1 WILL EVALUATE THE HYPOTHESIS THAT DYSREGULATION OF OREXIN PROCESSES UNDERLIES THE SHORT SLEEP PHENOTYPE IN FEMALE MONKEYS VIA OX2 RECEPTORS. WE WILL INVESTIGATE THE EFFECTS OF NOVEL OREXIN RECEPTOR LIGANDS ON ELECTRO- ENCEPHALOGRAPHY-BASED TELEMETRIC RECORDINGS OF SLEEP-WAKE CYCLES, AND WILL EVALUATE DIURNAL RHYTHMS OF CIRCU- LATING OREXIN LEVELS IN BLOOD. AIM 2 WILL EVALUATE THE HYPOTHESIS THAT PHENOTYPIC SHORT SLEEP INCREASES VULNERABILITY TO THE ADDICTIVE PROPERTIES OF METHAMPHETAMINE IN FEMALE RHESUS MONKEYS. ACQUISITION OF METHAMPHETAMINE SELF-ADMINISTRATION WILL BE EVALUATED ACROSS PHENOTYPES, AND WE WILL USE BEHAVIORAL ECONOMICS TO INVESTIGATE THE REINFORCING EFFECTIVENESS OF METHAMPHETAMINE. AIM 3 WILL EVALUATE THE HYPOTHESIS THAT THE REINFORCING EFFECTS OF METHAMPHETAMINE IN SHORT SLEEPERS ARE MODULATED UNIQUELY BY THE OX2 RECEPTOR SYSTEM. WE WILL INVESTIGATE THE EFFECTS OF DAYTIME AND NIGHTTIME TREATMENTS WITH OREXIN RECEPTOR AGONISTS AND ANTAGONISTS ON METHAMPHETA- MINE INTAKE IN SHORT VS NORMAL SLEEPERS. THE RESEARCH IN THIS APPLICATION ADDRESSES A KEY TOPIC FOR PUBLIC HEALTH BY PROPOSING TO INVESTIGATE THE EFFECTS OF SHORT SLEEP ON METHAMPHETAMINE INTAKE AND THE OREXIN MECHANISMS INVOLVED IN THIS PHENOMENON.

MISSISSIPPI CANCER REGISTRY - NPCR

6 MONTH NO COST EXTENSION FOR BP2/PHASE 2 CONTINUE INTO BP3/PHASE 3

NEW DRUGS FOR OPPORTUNISTIC INFECTIONS

NATIONAL CENTER FOR JUSTICE AND THE RULE OF LAW

SCREENING AND TREATMENT FOR MATERNAL DEPRESSION AND RELATED BEHAVIORAL DISORDERS PROGRAM

MECHANISMS OF TREG AND IL-35 IN REGULATING LV FAILURE-INDUCED LUNG REMODELING AND RIGHT HEART HYPERTROPHY

IONIC LIQUID-ASSISTED DRUG DELIVERY TO BRAIN RESERVOIRS FOR TREATMENT OF NEUROHIV - PROJECT SUMMARY/ABSTRACT DESPITE THE SUCCESS OF ANTIRETROVIRAL THERAPEUTICS (ARTS), THEY CANNOT ERADICATE HIV FROM RESERVOIRS WITHIN THE BODY, PARTICULARLY THOSE IN THE CENTRAL NERVOUS SYSTEM (CNS). MOREOVER, OPIOIDS UPREGULATE EFFLUX TRANSPORTERS FURTHER PROMOTING SUBTHERAPEUTIC CONCENTRATIONS OF ART IN THE CNS. WE HAVE USED BIOCOMPATIBLE IONIC LIQUIDS (ILS), MOLTEN SALTS COMPRISED OF ASYMMETRIC CATIONS AND ANIONS, THAT CAN `TUNE' THE AFFINITY OF NANOPARTICLES TO DIFFERENT CELL TYPES. USING THIS STRATEGY, WE HAVE DEVELOPED AN IL WITH A BALANCED AFFINITY FOR ERYTHROCYTES AND MICROGLIA WHICH PROMOTES NANOPARTICLE `HITCHHIKING' ON ERYTHROCYTES TO DELIVER THEM TO THE BRAIN, AND CELLS- SELECTIVE TARGETING OF MICROGLIA ONCE DELIVERED TO THE CENTRAL COMPARTMENT. PRELIMINARY DATA IN RATS DEMONSTRATE ~48% OF INJECTED NANOPARTICLES ACCUMULATING IN THE BRAIN WITHIN 6 HOURS, A VAST IMPROVEMENT OVER CURRENT NANOPARTICLE DELIVERY STRATEGIES. PRELIMINARY ANALYSES INDICATED THAT OVER 90% OF CNS NANOPARTICLES WERE ASSOCIATED WITH MICROGLIA. WE HAVE FURTHER DEMONSTRATED THE CAPACITY TO LOAD ART (ABACAVIR) INTO NANOPARTICLES WHICH RETAINED ANTIVIREMIC EFFICACY WHEN ADMINISTERED TO HIV-INFECTED HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS). WE HYPOTHESIZE THAT WE CAN FURTHER IMPROVE THE TUNABLE PROFILE OF OUR IL FORMULATION TO OPTIMIZE CARGO DELIVERY TO THE BRAIN AND TARGET ADDITIONAL CELL TYPES (INCLUDING ASTROCYTES). WE ANTICIPATE THAT THIS CARGO DELIVERY STRATEGY WILL BE SAFE AND EFFICACIOUS IN SPITE OF CNS CELL ADHESION/TRANSPORTER CHANGES PROMOTED BY OPIOID EXPOSURE/DEPENDENCE. TO THIS END, WE WILL (AIM 1) GENERATE AT LEAST 5 NOVEL ILS, IN ADDITION TO OUR CURRENT LEAD, WITH VARIED CELL-TYPE AFFINITY. WE WILL CONFIRM THE PREFERENCE THAT ILS CONFER TO SIMIAN AND HUMAN BLOOD COMPONENTS AS POTENTIAL CARGO CARRIERS. (AIM 2) WE WILL ASSESS THE SAFETY (SUBACUTE, ACUTE, SUBCHRONIC, REPRODUCTIVE, MUTAGENIC) AND BIODISTRIBUTION OF UP TO 5 NOVEL ILS IN RATS THAT ARE OPIOID-NAÏVE OR OPIOID-DEPENDENT. ILS WILL BE LOADED WITH A PREMADE SCRAMBLE CAS9 VECTOR WITH AN EGFP REPORTER TO CONFIRM THE CAPACITY TO DELIVER CRISPR-CAS9 CONSTRUCTS FOR POTENTIAL HIV CURE STRATEGIES. SAFE ILS WITH A CNS-FAVORABLE BIODISTRIBUTION WILL BE LOADED WITH CART (ABACAVIR, DOLUTEGRAVIR, AND LAMIVUDINE) AND ASSESSED FOR EFFICACY IN SIV-INFECTED OR HIV- INFECTED SIMIAN OR HUMAN PBMCS, RESPECTIVELY, OR HUMAN MICROGLIA. ALL CELLS WILL BE OPIOID-NAÏVE OR OPIOID- EXPOSED. ILS WITH SELECTIVITY FOR MICROGLIA AND ASTROCYTES WILL BE PRIORITIZED. (AIM 3) IL LEADS (BASED ON CNS DISTRIBUTION AND MICROGLIAL/ASTROCYTIC SELECTIVITY) WILL BE ASSESSED FOR IN VIVO SAFETY, BIODISTRIBUTION, AND ACUTE EFFICACY IN A RHESUS MACAQUE MODEL OF SIV. IN MACAQUES, IL-ASSISTED NANOPARTICLES WILL BE LOADED WITH NANOGOLD, IN ADDITION TO CART, TO CONFIRM THE TIME-COURSE OF BIODISTRIBUTION VIA X-RAY. SIV INFECTION WILL BE MONITORED VIA CSF AND BLOOD DRAWS. COMPLETE BLOOD COUNT, CHEMISTRY, AND CYTOKINE PROFILING WILL BE CONDUCTED ON PLASMA AND/OR CSF. ART DISTRIBUTION WILL BE CONFIRMED VIA LC/MS. GROSS HISTOPATHOLOGY WILL BE CONDUCTED ON ORGANS AND CNS TISSUES WILL BE ADDITIONALLY ASSESSED FOR MICROGLIOSIS, ASTROGLIOSIS, AND SUBLETHAL NEURONAL DAMAGE. IL- ASSISTED NANOPARTICLES MAY REALIZE THE GOAL OF ACHIEVING SAFE, CELL-SPECIFIC, CNS DRUG/CARGO DELIVERY.

DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCTS FOR PHARMACEUTICAL AND AGRICHEMICAL APPLICATIONS II

NATIONAL SEA GRANT LAW CENTER

ENDOTHELIN-1 IN OBESITY AND INSULIN RESISTANCE - PROJECT SUMMARY INSULIN RESISTANCE (IR) IS A MAJOR HEALTH PROBLEM IN THE U.S. IT PRECLUDES TYPE II DIABETES AND IS OFTEN PRESENT IN PATIENTS SUFFERING FROM OBESITY, BOTH BEING MAJOR RISK FACTORS FOR CARDIOVASCULAR DISEASE. CURRENTLY, MECHANISMS LEADING TO IR ARE NOT FULLY UNDERSTOOD. ET-1 IS A VASOACTIVE PEPTIDE PRIMARILY RELEASED BY ENDOTHELIAL CELLS. IT IS INCREASED IN PATIENTS WITH OBESITY AND ASSOCIATED WITH IR. ET-1 IS ELEVATED IN RESPONSE TO HYPOXIA, WHICH OCCURS IN INDIVIDUALS WITH OBESITY. IT ACTIVATES TWO RECEPTORS, ETA AND ETB, WHICH TYPICALLY OPPOSE EACH OTHER PHYSIOLOGICALLY. OUR PRELIMINARY DATA INDICATE THAT INHIBITING ETB RECEPTORS IN RODENTS, EITHER GENETICALLY OR PHARMACOLOGICALLY, IMPROVES INSULIN TOLERANCE AND REDUCES FASTING BLOOD GLUCOSE. THIS IMPROVEMENT IN GLUCOSE CONTROL IS ASSOCIATED WITH AN INCREASE IN PLASMA ADIPONECTIN AND ADIPOSE ADIPONECTIN AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPAR-) MRNA. IN ADDITION, ADIPOCYTE SPECIFIC ETB GAIN OF FUNCTION MICE HAVE EXACERBATED GLUCOSE INTOLERANCE IN RESPONSE TO HIGH FAT FEEDING, WHILE ADIPOCYTE ETB KNOCKOUT MICE HAVE IMPROVED GLUCOSE AND INSULIN TOLERANCE COMPARED TO FLOXED CONTROL LITTERMATES. THESE DATA SUGGEST THE ADIPOSE TISSUE AS A POSSIBLE TARGET FOR ET-1 INDUCED REDUCTION IN INSULIN SIGNALING. IT HAS BEEN PREVIOUSLY SHOWN THAT ACTIVATION OF ETB RECEPTORS ON CULTURED ADIPOCYTES INHIBITS THE ANTI-LIPOLYTIC EFFECTS OF INSULIN. FURTHERMORE, BLOCKADE OF ETB RECEPTORS IMPROVES INSULIN SENSITIVITY IN A RODENT MODEL OF SLEEP APNEA. THESE DATA SUGGEST THAT INCREASED ET-1 OBSERVED IN PATIENTS WITH OBESITY MAY PROMOTE IR VIA THE ETB RECEPTOR. THUS, WE HYPOTHESIZE THAT THAT OBESITY INDUCED TISSUE HYPOXIA PROMOTES ET-1/ETB RECEPTOR ACTIVATION IN ADIPOSE LEADING TO IR ON ADIPOCYTES, PPAR- INHIBITION AND REDUCED ADIPONECTIN RELEASE BY ADIPOCYTES THEREBY CAUSING IR IN MUSCLE AND LIVER TISSUE. TO TEST THIS HYPOTHESIS, WE WILL UTILIZE BOTH IN VIVO AND IN VITRO TECHNIQUES. FIRST, USING CULTURED ADIPOCYTES, WE WILL DETERMINE WHETHER ACTIVATION OF ETB RECEPTORS INHIBITS PPAR-, REDUCES ADIPONECTIN SECRETION, AND CAUSES INSULIN RESISTANCE ON ADIPOCYTES. NEXT, WE WILL USED CLINICALLY APPROVED INHIBITORS OF ET-1 RECEPTORS IN A MODEL OF DIET INDUCED OBESITY AND IR, AND WE WILL UTILIZE TWO NOVEL MOUSE MODELS THAT WERE PRODUCED BY OUR LAB THAT ALLOW US TO OVER-EXPRESS OR KNOCKOUT THE ETB. TO TEST THIS HYPOTHESIS, THE FOLLOWING SPECIFIC AIMS WILL BE TESTED: SPECIFIC AIM 1: TO TEST THE HYPOTHESIS THAT ETB RECEPTOR ACTIVATION DIRECTLY INHIBITS INSULIN SIGNALING ON ADIPOCYTES AND REDUCES ADIPONECTIN PRODUCTION BY INHIBITING PPAR-. SPECIFIC AIM 2: TO TEST THE HYPOTHESIS THAT ETB RECEPTOR ACTIVATION ON ADIPOCYTES PROMOTES INSULIN RESISTANCE BY INHIBITING PPAR- AND REDUCING ADIPONECTIN RELEASE IN MICE. SPECIFIC AIM 3: TO TEST THE HYPOTHESIS THAT ETB RECEPTOR BLOCKADE INCREASES PLASMA ADIPONECTIN AND IMPROVES INSULIN RESISTANCE IN OBESE MICE.

PROFESSIONAL STANDARDS FOR SCHOOL NUTRITION EMPLOYEES

CNP FSMI (O)

MISSISSIPPI PREVENTION TRAINING CENTER

HUMORAL FACTORS IN GENDER DIFFERENCES IN BP CONTROL

PROJECT ABSTRACT PURPOSE: THE PURPOSE OF THIS PROJECT IS TO CONTINUE THE NATIONAL SEA GRANT LAW CENTER'S OCEAN, COASTAL, AND GREAT LAKES LAW PROGRAMMING DURING THE 2024-2027 OMNIBUS PERIOD. THE NATIONAL SEA GRANT LAW CENTER IS A NATIONALLY RECOGNIZED AND RESPECTED RESOURCE FOR INFORMATION ON OCEAN, COASTAL, AND GREAT LAKES LAW. THE NATIONAL SEA GRANT LAW CENTER'S WORK IS GUIDED BY ITS STRATEGIC PLAN, INPUT FROM ITS ADVISORY COMMITTEE, AND METRICS AND INFORMATION COLLECTED AS PART OF THE EVALUATION PROCESS. THE OBJECTIVES AND ACTIVITIES OUTLINED IN THIS OMNIBUS APPLICATION ARE ALIGNED WITH THE NATIONAL SEA GRANT LAW CENTER'S VISION, MISSION, AND VALUES SET FORTH IN ITS 2024-2027 STRATEGIC PLAN. THIS WORK WILL SUPPORT ALL FOUR OF THE NATIONAL SEA GRANT COLLEGE PROGRAM'S FOCUS AREAS OF HEALTHY COASTAL ECOSYSTEMS, SUSTAINABLE FISHERIES AND AQUACULTURE, RESILIENT COMMUNITIES AND ECONOMIES, AND ENVIRONMENTAL LITERACY AND WORKFORCE DEVELOPMENT. ACTIVITIES TO BE PERFORMED: A WIDE RANGE OF PROJECT ACTIVITIES IS PROPOSED. THE NATIONAL SEA GRANT LAW CENTER WILL SUPPORT AND FACILITATE RESEARCH ON TIMELY OCEAN, COASTAL, AND GREAT LAKES LEGAL TOPICS THROUGH THE DEVELOPMENT AND IMPLEMENTATION OF RESEARCH COMPETITIONS TO AWARD FUNDS FOR PROGRAM DEVELOPMENT, COASTAL ADAPTATION AND RESILIENCE PROJECTS, AND SEA GRANT LAW & POLICY SYMPOSIA. USING TRADITIONAL LEGAL RESEARCH METHODOLOGIES, LAW CENTER ATTORNEYS WILL CONTRIBUTE TO THE FIELD OF OCEAN AND COASTAL LAW AND POLICY THROUGH THE ANALYSIS OF CURRENT ISSUES AND THE PUBLICATION OF THEIR RESEARCH RESULTS. IN ADDITION, LAW CENTER ATTORNEYS WILL RESPOND TO RESEARCH REQUESTS FROM SEA GRANT COLLEGE PROGRAMS AND STATE AND FEDERAL AGENCIES LOCATED ACROSS THE COUNTRY. DURING THE 2024-2027 OMNIBUS PERIOD, THE NATIONAL SEA GRANT LAW CENTER'S LEGAL RESEARCH EFFORTS WILL FOCUS ON THE PUBLIC TRUST DOCTRINE, STATE AQUACULTURE FRAMEWORKS, WATER QUALITY, AND DIRECT SEAFOOD SALES. THE NATIONAL SEA GRANT LAW CENTER WILL PUBLISH TWO EXTENSION PUBLICATIONS THE SANDBAR AND OCEAN AND COASTAL CASE ALERT AND A SCHOLARLY LEGAL JOURNAL - THE SEA GRANT LAW & POLICY JOURNAL. IN ADDITION, THE NATIONAL SEA GRANT LAW CENTER WILL CONDUCT EXTENSION ACTIVITIES RELATED TO ITS RESEARCH PROJECTS, INCLUDING WHITE PAPERS, FACT SHEETS, INFOGRAPHICS, AND CONFERENCE PRESENTATIONS. THE NATIONAL SEA GRANT LAW CENTER WILL ALSO ORGANIZE AND HOST AN ANNUAL WEBINAR SERIES. THROUGH SEVERAL INTERNSHIP PROGRAMS, THE NATIONAL SEA GRANT LAW CENTER WILL OFFER RESEARCH AND PUBLICATION OPPORTUNITIES TO UNDERGRADUATE AND LAW STUDENTS ON RELEVANT LEGAL TOPICS, INCLUDING ISSUES FACING UNDERREPRESENTED OR INDIGENOUS COMMUNITIES. COMMUNICATION PRODUCTS FROM THE NATIONAL SEA GRANT LAW CENTER INCLUDE ITS WEBSITE, BLOG, WEBINARS, NEWSLETTERS, SOCIAL MEDIA, AND OTHER RELATED PRODUCTS AND EFFORTS. EXPECTED OUTCOMES: AS A RESULT OF THE LEGAL RESEARCH, OUTREACH, AND EDUCATION ACTIVITIES SET FORTH IN THIS OMNIBUS APPLICATION, THE INTENDED BENEFICIARIES WILL HAVE INCREASED KNOWLEDGE OF THE LEGAL FRAMEWORK GOVERNING THE USE OF OCEAN, COASTAL, AND GREAT LAKES RESOURCES. THIS KNOWLEDGE WILL INCREASE THEIR CAPACITY TO ENGAGE IN POLICY DISCUSSIONS AND TAKE ACTION TO ADDRESS OCEAN, COASTAL, AND GREAT LAKES LEGAL ISSUES IN THEIR RESPECTIVE STATES. INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES OF THIS PROJECT ARE SEA GRANT PROGRAM STAFF, FEDERAL AND STATE NATURAL RESOURCE MANAGERS, POLICY- AND DECISION-MAKERS, AND COASTAL COMMUNITIES. SUBRECIPIENT ACTIVITIES: THIS OMNIBUS APPLICATION CONTAINS A PROJECT SELECTED THROUGH THE NATIONAL SEA GRANT LAW CENTER'S 2023 COASTAL RESILIENCE PROGRAM. RESEARCHERS AT THE UNIVERSITY OF MASSACHUSETTS- BOSTON WILL CONDUCT RESEARCH TO EXAMINE THE EFFECTIVENESS OF TWO CLIMATE ADAPTATION PROGRAMS IN MASSACHUSETTS.

WATER CONTAMINANTS AND CARDIOVASCULAR RISK: THE JACKSON HEART STUDY - PROJECT SUMMARY/ABSTRACT IN JACKSON, MS, DECADES OF UNDER-INVESTMENT IN PUBLIC WATER SYSTEM INFRASTRUCTURE HAVE RESULTED IN SEVERE DISRUPTIONS TO WATER ACCESS AND DIMINISHED WATER QUALITY. JACKSON HAS BEEN UNDER A CONSENT DECREE SINCE 2012 FOR FAILING TO MEET OPERATIONAL AND MAINTENANCE STANDARDS AND CONTINUES TO HAVE BOIL WATER NOTICES ISSUED REGULARLY, ELICITING CONCERN ABOUT THE HEALTH EFFECTS OF CHRONIC WATER CONTAMINANT EXPOSURES. DESPITE EMERGING RECOGNITION OF THE IMPORTANCE OF ENVIRONMENTAL EXPOSURES IN CARDIOMETABOLIC-CARDIOVASCULAR DISEASE (CM-CVD) RISK, FEW EPIDEMIOLOGIC STUDIES HAVE INVESTIGATED THE CM-CVD EFFECTS OF PUBLIC WATER CONTAMINANTS, EVEN THOUGH THESE DATA CAN PRIORITIZE POLICY-BASED SOLUTIONS TO LIMIT THEIR IMPACT. IN THIS CONTEXT, THE FLAGSHIP NHLBI/NIMHD- FUNDED JACKSON HEART STUDY (JHS), A PROSPECTIVE COHORT STUDY OF 5,306 AFRICAN-AMERICAN ADULTS, OFFERS A RARE OPPORTUNITY TO EVALUATE THE EFFECTS OF CHRONIC WATER CONTAMINANT EXPOSURES ON CM-CVD. IN PREPARATION FOR THIS APPLICATION, WE EXTRACTED ALL 165,580 COMPLIANCE MONITORING RECORDS (2000-2023) COLLECTED BY THE MISSISSIPPI DEPARTMENT OF HEALTH FOR 74 WATER SYSTEMS SERVING MADISON, HINDS, AND RANKIN COUNTIES COMPRISING JHS (ENCOMPASSING 38 UNIQUE ZIP CODES), DEMONSTRATING (1) SUBSTANTIAL TEMPORAL VARIABILITY (SEASONAL/YEARLY) IN PRIORITIZED WATER CONTAMINANTS (E.G., TOTAL TRIHALOMETHANES, HALOACETIC ACIDS, LEAD) ACROSS THESE WATER SYSTEMS; (2) SELECT WATER CONTAMINANTS LINKED TO CM-CVD (E.G., LEAD, DISINFECTION BYPRODUCTS) ARE HIGHER IN WATER SYSTEMS SERVING JHS COMMUNITIES COMPARED TO THOSE NATIONWIDE. STRIKINGLY, DISINFECTION BYPRODUCTS AND LEAD ARE LARGELY UNRELATED TO SOURCE WATER AND ARE DIRECTLY RELATED TO THE DETERIORATION AND MANAGEMENT OF WATER SYSTEM INFRASTRUCTURE, RELEVANT TO THE ONGOING JACKSON WATER CRISIS. OUR CENTRAL HYPOTHESIS IS THAT WATER TOXICANTS (CAPTURED BY WATER SYSTEM MONITORING RECORDS AND QUANTIFICATION OF ≈1000 CIRCULATING CHEMICALS IN THE BLOOD [“MOLECULAR EXPOSOME”] PIONEERED BY OUR GROUP) WILL BE ASSOCIATED WITH CM-CVD PHENOTYPES OVER ≈2 DECADES IN JHS. IN AIM 1, WE QUANTIFY 26 PUBLIC WATER CONTAMINANT EXPOSURES (INCLUDING DISINFECTION BYPRODUCTS, INORGANIC METALS, RADIONUCLIDES, ORGANIC COMPOUNDS) FOR ALL JHS PARTICIPANTS OVER ≈2 DECADES AND MEASURE THEIR ASSOCIATION WITH KEY CM-CVD RISK FACTORS (E.G., BLOOD PRESSURE, INSULIN RESISTANCE, OBESITY). AIM 2 PROVIDES A COMPLEMENTARY BIOCHEMICAL APPROACH, QUANTIFYING RELATION OF THE MOLECULAR EXPOSOME–AND ITS CHANGES OVER TIME–WITH THESE ENVIRONMENTAL EXPOSURES OVER ≈2 DECADES AND MEASURING THEIR RELATION TO CM-CVD PHENOTYPES. IN AIM 3, WE EXAMINE ASSOCIATION OF BOTH WATER MONITORING RECORDS AND BIOCHEMICAL EXPOSURES (MOLECULAR EXPOSOME) WITH 20-YEAR INCIDENT CVD RISK, INCLUDING HOW THESE RELATIONS MAY BE MEDIATED BY THE EFFECT OF WATER CONTAMINANT EXPOSURES ON TRADITIONAL CM-CVD RISK FACTORS. IF SUCCESSFUL, THIS APPLICATION WILL DEFINE THE IMPORTANCE OF WATER TOXICANT EXPOSURES TO CM-CVD OVER 2 DECADES IN A HIGHLY VULNERABLE, MINORITIZED COMMUNITY WITH A CONTAMINATED WATER SUPPLY, WITH DIRECT IMPLICATIONS FOR POLICY. RESOURCES GENERATED HERE WILL BE ACCESSIBLE TO THE SCIENTIFIC COMMUNITY FOR FUTURE DISCOVERY AND COMPARISON TO OTHER POPULATIONS.

SUD AND IPV AMONG MISSISSIPPI'S MOMS: INITIATIVE TO PREVENT AND TREAT (SIMM INITIATIVE) - THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER (UMMC) AND ITS PARTNERS, (1) MISSISSIPPI COALITION AGAINST DOMESTIC VIOLENCE, OFFERING SERVICES IN 78 OF MISSISSIPPI’S 82 COUNTIES; (2) CONVERGE: PARTNERS IN ACCESS; (3) MISSISSIPPI COALITION AGAINST SEXUAL ASSAULT; (4) MISSISSIPPI STATE DEPARTMENT OF HEALTH; (5) COMMUNITY HEALTH CENTER ASSOCIATION OF MISSISSIPPI, REPRESENTING 21 COMMUNITY HEALTH CENTERS THROUGHOUT MISSISSIPPI; AND (6) UNIVERSITY OF MISSISSIPPI’S CENTER FOR RESEARCH EVALUATION, PROPOSE TO ESTABLISH THE SUD AND IPV AMONG MISSISSIPPI’S MOMS: INITIATIVE TO PREVENT AND TREAT (SIMM INITIATIVE). THE SIMM INITIATIVE RECOGNIZES THE INTERCONNECTIONS BETWEEN SUBSTANCE USE DISORDER (SUD) AND INTERPERSONAL VIOLENCE (IPV) AMONG PREGNANT AND POSTNATAL WOMEN, AND IS AWARE OF THE NEED TO SCREEN AND TREAT FOR BOTH. MISSISSIPPI’S MENTAL HEALTH AND SUD PROVIDERS NEED TO BE TRAINED TO SCREEN AND REFER FOR TREATMENT THOSE WOMEN SUFFERING FROM IPV. CONCOMITANTLY, MISSISSIPPI’S COMMUNITY-BASED SERVICE PROVIDERS FOR PREGNANT AND POSTPARTUM WOMEN SUFFERING FROM IPV NEED TO BE TRAINED TO SCREEN AND REFER PATIENTS FOR SUD. THE SIMM INITIATIVE TEAM INCLUDES ACADEMIC MEMBERS AND PRACTITIONERS WITH EXPERTISE IN IDENTIFYING AND TREATING THOSE WITH SUD AND IPV, NURSING, PUBLIC HEALTH/DATA SCIENCE, BIOSTATISTICS, AND EVALUATION METHODOLOGY, AS WELL AS STATE- AND COMMUNITY-BASED ORGANIZATIONS AND PRACTITIONERS PROVIDING SERVICES TO MISSISSIPPIANS WITH A HISTORY OF EITHER SUD AND/OR IPV. TO COMPLETE ITS WORK, THE SIMM INITIATIVE HAS IDENTIFIED SEVEN GOALS AND 21 SMART OBJECTIVES (SMART IS AN ACRONYM FOR “SPECIFIC, MEASURABLE, ACHIEVABLE, RELEVANT, AND TIME-ORIENTED). THE GOALS ARE TO (1) ESTABLISH AND IMPLEMENT A PILOT PROJECT THAT INCENTIVIZES SUD PROVIDERS TREATING PREGNANT AND POSTPARTUM WOMEN IN MISSISSIPPI TO BE TRAINED ON IDENTIFYING AND ADDRESSING IPV; (2) DEVELOP AND IMPLEMENT AN SUD TRAINING PROGRAM FOR MISSISSIPPI’S COMMUNITY-BASED IPV STAFF MEMBERS THAT FOCUSES ON PREGNANT AND POSTPARTUM WOMEN; (3) BASED ON FEEDBACK FROM RECIPIENTS OF INITIAL SUD AND IPV TRAINING PROGRAMS, REVISE AS NECESSARY, AND DISSEMINATE WIDELY BEST PRACTICES FOR MANAGING CO-OCCURRING IPV AND SUD AMONG PREGNANT AND POSTPARTUM WOMEN; (4) DEVELOP AND IMPLEMENT STATEWIDE PLAN FOR INTEGRATING IPV AND SUD PROTOCOLS ACROSS HEALTHCARE SETTINGS; (5) PROVIDE TECHNICAL ASSISTANCE TO COMMUNITY-BASED IPV PROGRAMS TO BETTER ACCOMMODATE THE NEEDS OF PREGNANT AND POSTPARTUM WOMEN WITH SUD; (6) DEVELOP AND DISSEMINATE A DISPARITY IMPACT STATEMENT ON MISSISSIPPI’S PREGNANT AND POSTPARTUM WOMEN AT RISK FOR CO-OCCURRING SUD AND IPV; AND (7) MONITOR, EVALUATE, AND CONTINUOUSLY IMPROVE THE PROGRAMS AND SERVICES OFFERED BY THE SIMM INITIATIVE. TIMELY DISSEMINATION OF ITS WORK IS KEY TO THE SUCCESS OF THE SIMM INITIATIVE. TRAINING COURSES WILL BE PROVIDED BOTH IN PERSON AND THROUGH CONTINUING EDUCATION ON WEB-BASED PLATFORMS. ITS TRAINING AND INFORMATIONAL MATERIALS WILL BE WIDELY AVAILABLE AND DESIGNED TO BE EMBRACED BY MISSISSIPPI’S GENERAL PUBLIC, HEALTHCARE PROVIDERS, SERVICE PROVIDERS, COMMUNITY LEADERS, PUBLIC HEALTH OFFICIALS, AND STATE LEGISLATORS. NATIONALLY, THE SIMM INITIATIVE WILL SHARE ITS EXPERIENCES WITH COLLEAGUES, OTHER ORGANIZATIONS ATTEMPTING SIMILAR PROGRAMS, AND NATIONAL POLICY LEADERS. PLANS INCLUDE A ROBUST WEBSITE, PAMPHLETS AND OTHER MATERIALS WITH CULTURALLY-SENSITIVE MESSAGING DESIGNED FOR DIFFERENT AUDIENCES (PARTICULARLY THOSE IN RURAL SETTINGS), TRAINING GUIDES THAT ARE STRAIGHTFORWARD AND EASY TO UNDERSTAND, AND PRESENTATIONS DESIGNED FOR DIFFERENT AUDIENCES (E.G., COMMUNITY MEMBERS, HEALTH CARE PROFESSIONALS, POLICY ANALYSTS, ACADEMIC COLLEAGUES). FINALLY, MEMBERS OF THE SIMM INITIATIVE TEAM WILL PRESENT POSTERS AT PROFESSIONAL MEETINGS (E.G., REGIONAL AND NATIONAL MEETINGS OF ACADEMIC SOCIETIES AND ASSOCIATIONS), AND SUBMIT MANUSCRIPTS FOR PUBLICATION IN PEER-REVIEW

MISSISSIPPI SBDC

PROVISION OF TREATMENT FOR SUBSTANCE USE DISORDERS AND MENTAL HEALTH DISORDERS IN MISSISSIPPI TO REDUCE TRANSMISSION AND IMPROVE CLINICAL OUTCOMES IN PEOPLE LIVING WITH HIV

MOLECULAR BASES FOR ANTIMALARIAL DRUG ACTION: NEW INSIGHTS

ADVANCED NURSING EDUCATION GRANTS

IMPROVE EXISTING AIRPORT

COMMUNITY BASED DENTAL PARTNERSHIP

ROLE OF OBESITY IN BLOOD PRESSURE REGULATION AND INSULIN RESISTANCE IN POLYCYSTIC OVARY SYNDROME - POLYCYSTIC OVARY SYNDROME (PCOS) IS THE MOST COMMON ENDOCRINE DISORDER IN REPRODUCTIVE-AGE WOMEN. PCOS IS DIAGNOSED BY ELEVATED ANDROGENS, OVULATORY DYSFUNCTION, AND POLYCYSTIC OVARIES. WOMEN WITH PCOS HAVE A HIGH PREVALENCE OF CARDIOVASCULAR RISK FACTORS (CRFS), SUCH AS OBESITY, INSULIN RESISTANCE (IR), AND ELEVATED BLOOD PRESSURE (BP). EFFECTIVE THERAPEUTIC AGENTS TO TREAT CRFS FOUND IN PCOS WOMEN ARE LIMITED. THE LONG- TERM GOAL IS TO FIND EFFECTIVE AND SAFE THERAPEUTIC AGENTS TO TREAT CRFS IN PCOS WOMEN. THE RENIN-ANGIOTENSIN SYSTEM (RAS), WITH ITS CLASSICAL AND NONCLASSICAL PATHWAYS, IS A REGULATORY SYSTEM FOR BP CONTROL AND METABOLIC FUNCTION. THE ADIPOSE TISSUE HAS A FULLY FUNCTIONAL RAS WITH SYSTEMIC, PARACRINE, AND AUTOCRINE ACTIONS. THIS RESEARCH PROPOSAL WILL ELUCIDATE THE ROLE THAT THE ADIPOSE CLASSICAL AND NONCLASSICAL RAS PLAYS IN IR AND BP REGULATION IN PCOS. IR IS PRESENT IN LEAN AND OBESE PCOS WOMEN. PLASMA ADIPONECTIN LEVELS, AN INSULIN- SENSITIZING HORMONE, ARE LOW IN PCOS WOMEN, MAKING IT AN ATTRACTIVE MOLECULAR TARGET TO DECREASE IR. THE GOAL OF THIS PROPOSAL IS TO STUDY THE INTERPLAY BETWEEN ANDROGENS, ADIPOSITY, ADIPOSE CLASSICAL AND NONCLASSICAL RAS, AND ADIPONECTIN TO MEDIATE CRFS IN PCOS WOMEN. OUR CENTRAL HYPOTHESIS IS THAT “HYPERANDROGENEMIA HAS OBESITY-DEPENDENT AND -INDEPENDENT EFFECTS, LEADING TO INCREASED BP AND IR IN PCOS. ACTIVATION OF THE CLASSICAL AND INACTIVATION OF THE NONCLASSICAL ADIPOSE RAS LEAD TO INCREASED BP. FURTHERMORE, INDEPENDENT OF OBESITY, ANDROGENS CAUSE IR VIA DECREASED ADIPONECTIN LEVELS IN PCOS”. THIS NOVEL AND CLINICALLY RELEVANT HYPOTHESIS WILL BE TESTED WITH THESE AIMS: AIM 1: TO TEST THE HYPOTHESIS THAT OBESITY AS A RESULT OF HYPERANDROGENEMIA CAUSES AN ACTIVATION OF THE RAS AND INCREASES BP IN THE PCOS MODEL; AIM 2: TO TEST THE HYPOTHESIS THAT AN IMBALANCE OF THE ADIPOSE CLASSICAL AND NONCLASSICAL RAS IN RESPONSE TO HYPERANDROGENEMIA LEADS TO INCREASED BP IN THE PCOS MODEL; AIM 3: TO TEST THE HYPOTHESIS THAT DECREASES IN ADIPONECTIN IN RESPONSE TO HYPERANDROGENEMIA LEAD TO OBESITY-INDEPENDENT IR IN THE PCOS MODEL. WE WILL TEST THIS HYPOTHESIS USING AN INNOVATIVE COMBINATION OF GOLD-STANDARD METHODS TO MEASURE BP, IR, FAT DISTRIBUTION AND FUNCTION, AND SYSTEMIC AND ADIPOSE RAS PEPTIDES IN TWO WELL-CHARACTERIZED, CLINICALLY RELEVANT MODELS OF PCOS AND A 3D ADIPOCYTES CELL CULTURE. THE PROPOSED RESEARCH IS SIGNIFICANT BECAUSE IT WILL SHED LIGHT ON THE ANDROGENS- MEDIATED MECHANISMS AND THE INTERPLAY BETWEEN OBESITY, THE CLASSICAL AND NONCLASSICAL RAS, AND ADIPOKINES IN THE PATHOPHYSIOLOGY OF THE CRFS IN PCOS WOMEN. MOREOVER, THIS STUDY WILL IDENTIFY POTENTIAL NEW THERAPEUTIC OPTIONS TO AMELIORATE CRFS IN PCOS WOMEN.

INTEGRATIVE ROLE OF BILIRUBIN ON OBESITY

THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP TORNADO DETECTION AND TRACKING CAPABILITY USING RADIATED INFRASONIC SIGNALS. A PROTOTYPE OPERATIONAL NETWORK OF INFRASOUND DETECTION ARRAYS WILL BE DESIGNED AND DEPLOYED TO MONITOR TORNADO ACTIVITY IN A REGION THAT IS HISTORICALLY ACTIVE WITH SEVERE WEATHER, SPECIFICALLY TORNADOES. THE ARRAY GEOMETRY AND NETWORK CONFIGURATION WILL BE OPTIMIZED BASED ON STATISTICAL INFRASOUND PROPAGATION TOOLS DEVELOPED FOR DEFENSE APPLICATIONS. THOUGH IT IS EXPECTED THAT FOUR NINE-ELEMENT ARRAYS WILL SUFFICE; THE FINAL NETWORK DEPLOYED WILL BE BASED ON THE RESULTS OF THE OPTIMIZATION. TRACKING SOFTWARE WILL BE DEVELOPED BASED ON REAL-TIME PROCESSING ALGORITHMS USED AND TESTED IN DEFENSE APPLICATIONS FOR THE TRACKING OF MULTIPLE MOVING TARGETS. ADDITIONALLY, THE STUDY OF THE PHYSICAL MECHANISM THROUGH WHICH TORNADOES RADIATE INFRASOUND WILL CONTINUE, BOTH THEORETICALLY AND THROUGH THE DEPLOYMENT OF A SPECIALLY DESIGNED ARRAY CONSISTING OF UP TO 40 INFRASOUND S

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER (UMMC) IS HOME TO CHILDREN’S OF MISSISSIPPI, THE STATE’S ONLY CHILDREN’S HOSPITAL SERVING PEDIATRIC AND ADOLESCENTS ACROSS MISSISSIPPI. CHILDREN’S OF MISSISSIPPI IS CURRENTLY ABLE TO PROVIDE PSYCHIATRIC AND BEHAVIORAL HEALTH SERVICES FOR CHILDREN UP TO 13 YEARS OF AGE ON CAMPUS, AND FOR THOSE UP TO 17 YEARS OLD THERE ARE OUTPATIENT SERVICES AT THE CENTER FOR THE ADVANCEMENT OF YOUTH CENTER WHERE CHILDREN HAVE ACCESS TO A MULTIDISCIPLINARY TEAM PROVIDING SUPPORT FOR CONTINUING THERAPY. PSYCHIATRIC AND BEHAVIORAL HEALTH SERVICES FOR PATIENTS 18 YEARS AND OLDER ARE PROVIDED IN THE ADULT FACILITIES AT UMMC. HOWEVER, THESE SAME SERVICES FOR ADOLESCENTS BETWEEN 13 AND 17 YEARS OF AGE ARE SEVERELY LIMITED. THIS GAP RESULTS IN ADOLESCENTS NEEDING SPECIALIZED PSYCHIATRIC AND/OR BEHAVIORAL HEALTH SERVICES BEING HOUSED IN A REGULAR HOSPITAL PATIENT ROOM WITH 24-HOUR OBSERVATION. THESE VULNERABLE PATIENTS ARE UNABLE TO GET THE THERAPEUTIC INTERVENTIONS THEY NEED UNTIL AN ALTERNATIVE PLACEMENT CAN BE FOUND, WHICH CAN TAKE DAYS, WEEKS AND EVEN MONTHS. UMMC IS COMMITTED TO ACTIVELY ADDRESS THIS DISPARITY WITH THE CREATION OF A LEADING-EDGE ADOLESCENT BEHAVIORAL HEALTH INPATIENT FACILITY THAT PROMOTES HIGH QUALITY PATIENT AND FAMILY CENTERED CARE AND ADDRESSES THE NEEDS OF THE COMMUNITY, MEDICAL CENTER AND STAFF. GRANT FUNDING FROM CPF/CDS WILL ALLOW UMMC TO BEGIN CREATING THE SPACE NEEDED TO MEET THE MENTAL, EMOTIONAL AND PHYSICAL NEEDS OF THIS UNIQUE ADOLESCENT PATIENT POPULATION THROUGH AN ADOLESCENT BEHAVIORAL HEALTH INPATIENT UNIT (ABHIU). THIS NEW 10-BED INPATIENT UNIT WILL BE CONSTRUCTED ON THE SECOND FLOOR OF EXISTING UMMC HOSPITAL SPACE ONCE THE PEDIATRIC MEDICAL SUPPORT AND PATIENT SERVICES AND THAT CURRENTLY OCCUPY THE AREA ARE SUCCESSFULLY RELOCATED. THE IDENTIFIED SPACE, ONCE EMPTY, WILL NEED TO UNDERGO A COMPLETE RENOVATION IN ORDER TO MAKE IT CODE COMPLIANT, SAFE AND FUNCTIONAL FOR THESE ADOLESCENT PATIENTS. THE NUMBER OF MISSISSIPPI CHILDREN AND ADOLESCENTS IN DESPERATE NEED OF BEHAVIORAL HEALTH SERVICES IS INCREASING. INFORMATION IN THE STATE OF MENTAL HEALTH IN AMERICA 2022 , REPORTS THAT MISSISSIPPI IS RANKED LAST IN THE NATION FOR YOUTH WITH MAJOR DEPRESSION WHO DID NOT RECEIVE ANY MENTAL HEALTH TREATMENT. THIS PROJECT WILL PROVIDE MISSISSIPPI WITH A LEADING-EDGE ADOLESCENT BEHAVIORAL HEALTH UNIT THAT PROMOTES HIGH QUALITY PATIENT AND FAMILY CENTERED CARE, AND ADDRESSES THE NEEDS OF THE COMMUNITY, MEDICAL CENTER AND STAFF.

PURPOSE: EXPAND THE SCIENTIFIC AND TECHNOLOGICAL CAPABILITIES OF APPLICANTS SPECIALIZED CENTER (CGRI), WHICH WILL SERVE AS A CORE TEST FACILITY FOR GRAPHENE AND GRAPHENE-LIKE MATERIALS.ACTIVITIES TO BE PERFORMED: ESTABLISH A UNIFIED TESTING PROGRAM WITHIN A CORE TESTING FACILITY THAT IS DEDICATED TO GRAPHENE AND SIMILAR MATERIALS. ACQUIRE NECESSARY EQUIPMENT TO EXPAND THESE CAPABILITIES. PARTNER WITH NATIONAL AND INTERNATIONAL BODIES, SUCH AS INTERNATIONAL ORGANIZATION FOR STANDARDIZATION, AMERICAN NATIONAL STANDARDS INSTITUTE, NATIONAL PHYSICAL LABORATORY AND NIST TO UTILIZE THE CURRENT AND IN-DEVELOPMENT TESTING AND CHARACTERIZATION GUIDELINES TO DELIVER COMPLETE SOLUTIONS TO END USERS.EXPECTED OUTCOMES: ENHANCEMENT OF THE GLOBAL COMPETITIVENESS OF U.S. INDUSTRIES, ABILITY TO CATER TO THE NEEDS OF LOCAL, REGIONAL, AND NATIONAL STAKEHOLDERS OF GRAPHENE AND GRAPHENE-LIKE MATERIALS, SUCH AS COMPANIES, STATE, AND FEDERAL AGENCIES, AND RESEARCH INSTITUTIONS, AND POSITIVE ECONOMIC IMPACT FOR MISSISSIPPI, SOUTHEAST REGION, AND THE NATION.INTENDED BENEFICIARIES: NIST: GRAPHENE RESEARCH IS AN IMPORTANT MISSION FOR NIST. A CORE TESTING FACILITY FOR GRAPHENE AND GRAPHENE-LIKE MATERIALS THAT COULD FACILITATE BRIDGING BETWEEN SCIENCE-BASED DISCOVERY AT ITS HIGHEST LEVEL, I.E., NANOSCIENCE, AND ENGINEERING APPLICATIONS AND MARKET WOULD BE BENEFICIAL. MISSISSIPPI: ENHANCE MISSISSIPPI SCIENCE AND TECHNOLOGY INFRASTRUCTURE, AID IN THE DEVELOPMENT AND MAINTENANCE OF A MORE ROBUST SCIENCE AND TECHNOLOGY WORKFORCE AND DIVERSIFY AND IMPROVE MISSISSIPPI'S ECONOMY. PUBLIC: THE CORE TESTING FACILITY FOR GRAPHENE AND GRAPHENE-LIKE MATERIALS WILL BRING ABOUT TRANSFORMATIVE TECHNOLOGICAL INNOVATIONS, ENHANCING THE GLOBAL COMPETITIVENESS OF U.S. INDUSTRIES, BOOSTING REGIONAL AND NATIONAL ECONOMY, AND BENEFITING THE SOCIETY OVERALL. A HOPED-FOR OUTCOME IS FOR INNOVATIONS DEVELOPED IN THE U.S. TO BE MANUFACTURED IN THE U.S. SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES INTEND TO SUB AWARD FUNDS.

CN NFSMI

CN NFSMI

RURAL EMERGENCY MEDICAL COMMUNICATIONS DEMONSTRATION PROJECT (REMCDP)

RURAL EMERGENCY MEDICAL COMMUNICATIONS DEMONSTRATION PROJECT

NATIONAL CENTER FOR JUSTICE AND THE RULE OF LAW

REGULATION OF IL-6-TYPE CYTOKINE CARDIOPROTECTIVE SIGNALING IN THE ISCHEMIC HEART

RURAL EMERGENCY MEDICAL COMMUNICATIONS DEMONSTRATION PROJECT

DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCTS FOR PHARMACEUTICAL AND AGRICHEMICAL APPLICATIONS

LOW BIRTH WEIGHT, THE KIDNEY, AND HYPERTENSION

THE UNIVERSITY OF MISSISSIPPI WILL IMPLEMENT CURRICULUM IN ENGLISH CLASSES THAT TEACH SKILLS OF CIVIL DIALOGUE AND ETHICAL REASONING; TRAINING AUTHORITY FIGURES SUCH AS PARENTS, COMMUNITY MEMBERS (INCLUDING LAW ENFORCEMENT), SCHOOL STAFF (COUNSELORS, ADMINISTRATORS, AND SCHOOL RESOURCE OFFICERS), AND TEACHERS IN CIVIL DIALOGUE AND CURRICULUM REINFORCEMENT; PROVIDING SCHOOLS WITH SAFETY PLANS AND BEHAVIORAL THREAT ASSESSMENT TRAINING AND TECHNICAL ASSISTANCE; AND CREATING STUDENT OPPORTUNITY NETWORKS THROUGH AFTER-SCHOOL PROGRAMS AND STATE-WIDE COMPETITIONS FOR SCHOOL TEAMS. THIS INTERDISCIPLINARY PROGRAM WITH EXPERTS FROM PHILOSOPHY AND ETHICS, PSYCHOLOGY, SOCIAL WORK, EDUCATION, AND CRIMINAL JUSTICE BRINGS THE RESOURCES OF MULTIPLE NATIONAL CENTERS BASED AT THE STATE FLAGSHIP UNIVERSITY TO SUPPORT THE SUBRECIPIENT PARTNER, THE CENTER FOR URBAN FAMILY HEALTH AND WHOLENESS, TO MEET PRIORITY AREA 1B. THE UNIVERSITY-COMMUNITY PARTNERSHIP WILL BENEFIT MIDDLE AND HIGH SCHOOLS FROM TEN RURAL SCHOOL DISTRICTS (COVINGTON COUNTY SCHOOLS, HAZLEHURST PUBLIC SCHOOLS, HINDS COUNTY SCHOOLS, LAUREL PUBLIC SCHOOLS, MCCOMB PUBLIC SCHOOLS, MOSS POINT SCHOOL DISTRICT, NORTH PIKE COUNTY SCHOOLS, SOUTH PIKE COUNTY SCHOOLS, VICKSBURG-WARREN COUNTY SCHOOLS, AND YAZOO COUNTY SCHOOLS) TO IMPACT AN ESTIMATED 22,000 STUDENTS. EXPECTED OUTCOMES INCLUDE A REDUCTION OF TRUANCY, VERBAL CONFLICTS, BULLYING, AND FREQUENCY AND SEVERITY OF VIOLENT BEHAVIORS, AS WELL AS AN IMPROVEMENT OF THREAT ASSESSMENT, EMERGENCY PLANNING, PROTECTIVE FACTORS, AND COHESIVE SUPPORT AND REINFORCEMENT. PROFESSIONAL DEVELOPMENT WORKSHOPS AND TRAININGS WILL IMPACT AN ESTIMATED 150 TEACHERS, 80 SCHOOL RESOURCE OFFICERS, COUNSELORS, AND ADMINISTRATORS, AND 30,000 PARENTS AND COMMUNITY MEMBERS (INCLUDING LAW ENFORCEMENT). THE PROGRAM INCLUDES ROBUST RESEARCH TO ASSESS PROGRAM IMPLEMENTATION AND EFFECTIVENESS AND TO ADVANCE EVIDENCE-BASED PRACTICES ON SCHOOL CLIMATE USING LARGE-SCALE PRE AND POST IMPLEMENTATION SURVEYS AND FOCUS GROUP INTERVIEWS, FOCUSED ASSESSMENTS AFTER WORKSHOPS AND TRAININGS, AND EXTENSIVE DATA ON STUDENT LEARNING AND BEHAVIOR.

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING (BHWET) PROGRAM

OPIOID RECEPTOR POLYMORPHISMS AND NONHUMAN PRIMATE MODELS OF ALCOHOL ABUSE

FRACTAL ANALYSIS OF CERAMIC FPDS

A NOVEL THERAPY FOR PREECLAMPSIA

INTELLIGENCY COMMUNITY - CENTERS FOR ACADEMIC EXCELLENCE

MISSISSIPPI SBDC CARES ACT

RURAL EMERGENCY MEDICAL COMMUNICATIONS DEMONSTRATION PROJECT (REMCDP)

GENETIC DETERMINANTS OF HYPERTENSION-INDUCED CEREBRAL VASCULAR DYSFUNCTION

HYPERTENSION, INFLAMMATION, AND VASCULAR FUNCTION

INTENSITY FRONTIER STUDIES WITH HEAVY QUARKS AND LEPTONS AND MUON ACCELERATOR STUDIES

THE RENAL MEDULLA AND HYPERTENSION

MECHANISMS OF CARDIORENAL DISEASE FOLLOWING PREECLAMPSIA

NEURAL MECHANISMS OF SOUND ACTIVATION OF VESTIBULAR SYSTEM

FUNCTIONAL GENETIC EVOLUTION OF HUMAN BRAIN AND BEHAVIOR

GENETICS OF RENAL END ORGAN DAMAGE IN HYPERTENSION

UNPREDICTABLE AVAILABILITY AS A DETERMINANT OF DRUG-RELATED OUTCOMES

DESIGN OPTIMIZATION OF REDUCED-DIAMETER IMPLANTS IN SIMULATED AND CADAVER BONE

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM ? MENTAL AND BEHAVIORAL HEALTH - - PROJECT TITLE: EVIDENCE-BASED TREATMENT FOR RURAL INTERVENTION COURTS (ERIC) - REQUESTED AWARD AMOUNT: $1,941,559.00 - APPLICANT ORGANIZATION NAME: UNIVERSITY OF MISSISSIPPI MEDICAL CENTER (UMMC) - APPLICANT ORGANIZATION ADDRESS: 2500 N. STATE ST., JACKSON, MS, 39216 - APPLICANT ORGANIZATION FACILITY TYPE: ACADEMIC MEDICAL CENTER - PROJECT DIRECTOR NAME AND TITLE: ANDREW VOLUSE, PH.D., ASSOCIATE PROFESSOR - PROJECT DIRECTOR CONTACT INFORMATION: PHONE: (601) 984-5818; EMAIL: AVOLUSE@UMC.EDU - DATA COORDINATOR NAME AND TITLE: TO BE HIRED - EIN/DUNS NUMBER EXCEPTION REQUEST IN ATTACHMENT 8?: NO - HOW THE APPLICANT FIRST LEARNED ABOUT THE FUNDING OPPORTUNITY: HRSA PROJECT OFFICER - NUMBER OF CONSORTIUM MEMBERS & LIST OF CONSORTIUM MEMBERS: 8 TOTAL: UMMC AND THE MISSISSIPPI ADULT FELONY DRUG INTERVENTION COURTS FOR THE 4TH, 10TH, 12TH, 14TH, 17TH, 18TH, AND 19TH JUDICIAL CIRCUITS - IS THE APPLICANT ORGANIZATION A PREVIOUS OR CURRENT RCORP AWARD RECIPIENT OR CONSORTIUM MEMBER?: NO - INDICATE IF APPLICANT ORGANIZATION INTENDS TO APPLY FOR FY22 RCORP-IMPLEMENTATION: YES - DOES THE TARGET SERVICE AREA OVERLAP WITH THE SERVICE AREAS OF THE NORTHERN BORDER REGIONAL COMMISSION, THE DELTA REGIONAL AUTHORITY, OR THE APPALACHIAN REGIONAL COMMISSION?: YES. DELTA REGIONAL AUTHORITY - RCORP-BHS TARGET SERVICE AREA O FULLY RURAL COUNTIES IN MISSISSIPPI: CLARKE; GEORGE; GREENE, JONES, KEMPER, LAUDERDALE, LEFLORE, LINCOLN, PANOLA, PERRY, PIKE, SUNFLOWER, TALLAHATCHIE, TATE, WALTHALL, WASHINGTON, WAYNE, & YALOBUSHA O PARTIALLY RURAL COUNTIES: NONE - BRIEF DESCRIPTION OF THE TARGET POPULATION: THIS PROJECT WILL PROVIDE MENTAL HEALTH SERVICES TO MISSISSIPPI ADULT FELONY DRUG INTERVENTION COURT PARTICIPANTS LIVING IN RURAL COUNTIES. ANTICIPATED DEMOGRAPHIC CHARACTERISTICS FOR THIS POPULATION ARE 23% AFRICAN AMERICAN OR BLACK, 0.5% HISPANIC, 0.2% NATIVE AMERICAN, AND 29.8% FEMALE. BRIEF SUMMARY: THIS PROPOSAL, ENTITLED EVIDENCE-BASED TREATMENT FOR RU RAL INTERVENTION COURTS (ERIC), SEEKS TO REDUCE MORBIDITY AND MORTALITY OF SUBSTANCE USE DISORDERS (SUDS) AND CO-OCCURRING MENTAL HEALTH DISORDERS (WITH PARTICULAR EMPHASIS ON POST-TRAUMATIC STRESS DISORDER) IN TARGETED HIGH NEED (I.E., SUBSTANTIAL BURDEN OF SUD AND MENTAL ILLNESS), LOW RESOURCE (I.E., SCARCITY OF MENTAL HEALTH PROVIDERS) RURAL MISSISSIPPI COUNTIES BY IMPROVING ACCESS TO EVIDENCE-BASED MENTAL HEALTH SERVICES FOR INDIVIDUALS PARTICIPATING IN THE STATE’S ADULT FELONY DRUG INTERVENTION COURT PROGRAM.

HYPERTENSION, KIDNEY AND PREGNANCY

DEGENERIN AND TRPC6 CHANNELS IN RENAL VASCULAR MECHANOSESNSOR SIGNALING AND PROTECTION AGAINST INJURY. - ABSTRACT MECHANOSENSING IS A PROCESS INHERENT TO NEARLY ALL CELL TYPES, INCLUDING VASCULAR SMOOTH MUSCLE (VSM) CELLS WHERE PRESSURE-INDUCED VASCULAR STRETCH INITIATES A MECHANO-DEPENDENT VASOCONSTRICTION. THIS RESPONSE, TERMED PRESSURE-INDUCED CONSTRICTION, OCCURS IN NUMEROUS ORGANS INCLUDING THE KIDNEY AND SERVES AT LEAST TWO FUNCTIONS: CONTROL OF LOCAL BLOOD FLOW AND PREVENTION OF TRANSMISSION OF DAMAGING HIGH SYSTEMIC PRESSURES TO DELICATE MICROVESSELS. A LOSS OF THE PRESSURE-INDUCED CONSTRICTION RESPONSE INCREASES SUSCEPTIBILITY TO VASCULAR INJURY IN ORGANS, INCLUDING THE KIDNEY WHERE A LOSS OF THIS RESPONSE ACCELERATES PROGRESSION OF CHRONIC KIDNEY DISEASE. DESPITE THE IMPORTANCE OF THE PRESSURE-INDUCED CONSTRICTION RESPONSE, MOLECULAR MECHANISM(S) UNDERLYING ITS INITIATION REMAIN UNCLEAR. WE HAVE SHOWN THAT MEMBERS OF EPITHELIAL NA+ CHANNEL (ENAC)/DEGENERIN FAMILY OF ION CHANNELS (BENAC AND ASIC2) ARE REQUIRED FOR RENAL AFFERENT ARTERIOLAR PRESSURE- INDUCED CONSTRICTION. THE ROLE OF OTHER FAMILY MEMBERS, INCLUDING GENAC, IS UNKNOWN. TRPC6 HAS BEEN SUGGESTED TO CONTRIBUTE TO VASCULAR MECHANOSIGNALING IN CEREBRAL ARTERIES. HOWEVER, ITS ROLE IN PRESSURE-INDUCED CONSTRICTION IN RENAL AFFERENT ARTERIOLES IS UNKNOWN. WE RECENTLY FOUND THAT B AND GENAC AND ASIC2 FORM FUNCTIONAL, MECHANOACTIVATED CHANNELS WHEN EXPRESSED IN XENOPUS OOCYTES. OUR PROPOSED STUDIES ADDRESS THE HYPOTHESIS THAT B/GENAC-ASIC2 CHANNELS AND TRPC6 HAVE DIFFERENT ROLES IN VSM CELL MECHANO-SIGNALING IN RENAL AFFERENT ATHERIOLES. SPECIFICALLY, B/GENAC-ASIC2 CHANNELS MEDIATE MECHANO-RECEPTOR CURRENTS, WHEREAS TRPC6 CHANNELS CONTRIBUTE TO SIGNAL AMPLIFICATION. IN SPECIFIC AIM 1, WE WILL USE THE XENOPUS OOCYTE EXPRESSION SYSTEM TO DEFINE THE FUNCTIONAL CHARACTERISTICS OF B/GENAC-ASIC2 CHANNELS, AND DETERMINE THE MECHANISTIC ROLES OF B AND GENAC, ASIC2 AND TRPC6 IN MECHANO-RECEPTOR CURRENTS AND POST-MECHANO-RECEPTOR CA2+ SIGNALING IN RENAL AFFERENT VSM CELLS. IN SPECIFIC AIM 2, WE WILL DETERMINE THE CONTRIBUTIONS OF B AND GENAC, ASIC2 AND TRPC6 TO PRESSURE- INDUCED CONSTRICTION IN RENAL AFFERENT ARTERIOLES. IN SPECIFIC AIM 3, WE WILL DETERMINE IF VSM-SPECIFIC LOSS OF EXPRESSION OF ENAC SUBUNITS, ASIC2 OR TRPC6 CONTRIBUTES TO RENAL INJURY IN THE SETTING OF HYPERTENSION. IN SUMMARY, OUR PROPOSED STUDIES WILL DETERMINE THE MECHANISTIC ROLES OF B/GENAC-ASIC2 AND TRPC6 CHANNELS IN MECHANICAL SIGNALING AND IN PROTECTING AGAINST KIDNEY INJURY.

ESTABLISHING A SCIENTIFIC COMPUTING HUB AT THE UNIVERSITY OF MISSISSIPPI

ANTI-INFLAMMATORY ROLES AND MACROPHAGE METABOLISM OF LACTATE AND KETONES DURING MYOCARDIAL INFARCTION - PROJECT SUMMARY/ABSTRACT APPROXIMATELY 1 MILLION PEOPLE IN THE UNITED STATES SUFFER A MYOCARDIAL INFARCTION (MI) EACH YEAR, LEADING TO PROGRESSIVE CARDIAC DYSFUNCTION AND DEVELOPMENT OF HEART FAILURE (HF) IN ~25% OF SURVIVING PATIENTS. DIABETES MELLITUS IS A MAJOR RISK FACTOR FOR MI, AND PATIENTS WITH DIABETES SUFFER FROM HIGHER MORTALITY RATES AND INCREASED RISK OF DEVELOPING HF. DUE TO THE LIMITED SUCCESS OF CURRENT THERAPIES IN PREVENTING ADVERSE CARDIAC REMODELING AFTER MI, NOVEL THERAPEUTIC TARGETS ARE NEEDED TO EFFECTIVELY PROMOTE ADEQUATE HEALING AND LIMIT TISSUE DAMAGE, ESPECIALLY IN DIABETIC PATIENTS. EXCESSIVE MACROPHAGE-MEDIATED INFLAMMATION IS A KEY MECHANISM LEADING TO ADVERSE CARDIAC REMODELING AFTER MI, AND PATIENTS WITH DIABETES DISPLAY EXACERBATED AND PERSISTENT POST-MI INFLAMMATORY RESPONSES. A KEY MECHANISM BY WHICH MACROPHAGES POLARIZE BETWEEN THE PRO-INFLAMMATORY “M1” AND ANTI-INFLAMMATORY/PRO-REPARATIVE “M2” SUBSETS IS VIA METABOLIC REPROGRAMMING CHARACTERIZED BY PHENOTYPIC SWITCHES BETWEEN GLYCOLYTIC METABOLISM, WHICH PROMOTES M1 POLARIZATION, AND MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION (OXPHOS), WHICH PROMOTES M2 POLARIZATION. USING SEAHORSE METABOLIC FLUX ANALYSIS, I HAVE FOUND THAT DURING THE EARLY INFLAMMATORY PHASE (DAY 1 AND 3 AFTER MI IN MICE), INFARCT MACROPHAGES BECOME GLYCOLYTIC, WHEREAS DURING THE HEALING PHASE (DAY 7), MACROPHAGES REVERT TO GLUCOSE OXIDATION AND OXPHOS. IN ADDITION TO GLUCOSE, MACROPHAGES CAN METABOLIZE “ALTERNATIVE” FUELS, INCLUDING LACTATE AND KETONE BODIES, WHICH PROMOTE AN M2 PHENOTYPE. HOWEVER, THE ROLE OF LACTATE AND KETONE BODY METABOLISM BY MACROPHAGES DURING MI IS UNKNOWN, AND WHETHER ADMINISTRATION OR ENDOGENOUS PRODUCTION OF THESE COMPOUNDS CAN PROMOTE M2 MACROPHAGE POLARIZATION DURING MI IS ALSO NOT KNOWN. MY PRELIMINARY DATA INDICATE THAT EXPRESSION OF GENES RELATED TO LACTATE (MCT1, LDHB) AND KETONE (OXCT1) METABOLISM ARE UPREGULATED IN MACROPHAGE DURING THE WOUND HEALING PHASE OF MI. FURTHER PRELIMINARY DATA INDICATES THAT IN VIVO ADMINISTRATION OF LACTATE OR KETONES, OR FEEDING A KETOGENIC DIET ATTENUATES THE MACROPHAGE IMMUNOMETABOLIC PHENOTYPE AFTER MI. THIS INDICATES THAT METABOLISM OF THESE SUBSTRATES MAY UNDERLIE M2 POLARIZATION AND CARDIAC HEALING AFTER MI. THUS, THE HYPOTHESIS FOR THIS PROPOSAL IS THAT ELEVATED ENDOGENOUS PRODUCTION OR EXOGENOUS ADMINISTRATION OF LACTATE AND KETONES WILL IMPROVE CARDIAC REMODELING AND REDUCES CARDIAC INJURY AFTER MI VIA IMPROVED MACROPHAGE METABOLISM AND POLARIZATION. I ALSO PROPOSE THAT DIABETES EXACERBATES MI INJURY VIA IMPAIRED MACROPHAGE LACTATE AND KETONE METABOLISM. TO ADDRESS THESE HYPOTHESES, I WILL USE CLINICALLY RELEVANT MOUSE MODELS OF MI AND DIABETES MELLITUS, AND MACROPHAGE-SPECIFIC GENETICALLY MODIFIED MICE, COUPLED WITH STATE-OF- THE-ART TECHNIQUES FOR MEASURING CARDIAC FUNCTION (HIGH RESOLUTION ULTRASOUND ECHOCARDIOGRAPHY AND 4D IMAGING), LIVE CELLULAR METABOLISM, MACROPHAGE ISOLATION BY IMMUNOMAGNETIC SORTING, AND FLOW CYTOMETRY. THESE STUDIES WILL PROVIDE NEW MECHANISMS OF LACTATE AND KETONE-MEDIATED CARDIOPROTECTION, AND NOVEL STRATEGIES FOR TARGETING MACROPHAGE METABOLISM FOLLOWING CARDIAC INJURY.

POISON CONTROL STABILIZATION AND ENHANCEMENT PROGRAM