Maia

STRENGTHEN THE FEDERAL GOVERNMENT OF SOMALIA (FGS)S ABILITY TO COUNTER AL-SHABAAB FINANCING AND TAX COLLECTION EFFORTS BY ENCOURAGING THE PUBLIC TO REPORT ON KNOWN OR SUSPECTED AL-SHABAAB TAX COLLECTORS AND SCHEMES

HIAPO PROGRAM: EMPOWERING HAWAII’S FUTURE TECH WORKFORCE THROUGH A TRAINING AND APPRENTICESHIP PROGRAM

FOUNDHER

SBIR PHASE II: REAL-TIME DECISION MAKING SOFTWARE FOR WASTEWATER TREATMENT OPERATORS

NOVEL TELOMERE-TARGETING THERAPY FOR ADVANCED NON-SMALL CELL LUNG CANCER - SUMMARY: WITH NON-SMALL CELL LUNG CANCER (NSCLC) PERSISTING AS A LEADING CAUSE OF CANCER MORTALITY WORLDWIDE AND RESISTANT TO MANY STANDARD TREATMENTS, MAIA BIOTECHNOLOGY, INC. IS FOCUSED ON DEVELOPING THIO, A NOVEL THERAPEUTIC AGENT AIMED AT IMPROVING TREATMENT OUTCOMES IN PATIENTS WITH ADVANCED-STAGE NSCLC. THIO, A DIRECT TELOMERE TARGETING AGENT, IS DESIGNED TO EXPLOIT THE VULNERABILITY OF CANCER CELLS’ TELOMERASE-DEPENDENCY, OFFERING A NEW AVENUE FOR THERAPEUTIC INTERVENTION IN CASES WHERE EXISTING OPTIONS FAIL. TO ADDRESS THE LIMITED EFFICACY AND RESISTANCE ISSUES ASSOCIATED WITH CURRENT NSCLC TREATMENTS, OUR OBJECTIVE IS TO EVALUATE THE SAFETY AND EFFICACY OF THIO IN COMBINATION WITH THE IMMUNE CHECKPOINT INHIBITOR CEMIPLIMAB IN A MULTICENTER, OPEN- LABEL, SINGLE-ARM PHASE 2 CLINICAL STUDY. THE STUDY WILL ENROLL SUBJECTS WITH STAGE 3 OR 4 NSCLC WHO HAVE SHOWN RESISTANCE TO PRIOR CHECKPOINT INHIBITORS, UTILIZING THIO'S MECHANISM OF CAUSING TUMOR CELL DEATH BY INCORPORATION INTO TELOMERES AND INDUCING INSTABILITY. THIS PHASE 2 CLINICAL TRIAL FOLLOWS PROMISING PRECLINICAL AND EARLY CLINICAL RESULTS WHERE THIO SHOWED HIGH SELECTIVITY IN KILLING TELOMERASE-ACTIVE CANCER CELLS AND SIGNIFICANT SYNERGY WITH IMMUNE CHECKPOINT INHIBITORS. GIVEN THE HIGH INCIDENCE OF NSCLC AND THE SIGNIFICANT PORTION OF PATIENTS LACKING EFFECTIVE TREATMENT OPTIONS, THE SUCCESSFUL DEVELOPMENT OF THIO COULD DRAMATICALLY ENHANCE QUALITY OF LIFE AND SURVIVAL RATES BY PROVIDING A NEW, EFFECTIVE TREATMENT MODALITY. THIS PROJECT NOT ONLY ADDRESSES AN URGENT PUBLIC HEALTH NEED BUT ALSO ADVANCES OUR UNDERSTANDING OF CANCER BIOLOGY AND TREATMENT, POTENTIALLY OFFERING BROADER IMPLICATIONS FOR OTHER TELOMERASE-POSITIVE CANCERS.

PURPOSE: THE GOAL OF THIS PROJECT IS TO EMPOWER HAWAIIS INDIGENOUS FISHPOND PRACTITIONERS, COASTAL COMMUNITIES, AND LOCAL GOVERNMENT WITH ENVIRONMENTAL DATA CUSTOMIZED TO INDIVIDUAL WATERSHED NEEDS IN SUPPORT OF BIOCULTURAL RESTORATION AND CLIMATE CHANGE MONITORING AND MITIGATION. FISHPONDS ARE TRADITIONAL HAWAIIAN AQUACULTURE SITES AND FISHPOND PRACTITIONERS ARE ATTEMPTING TO RECREATE SUSTAINABLE COASTAL FISH FARMING OPERATIONS THAT ONCE THRIVED THROUGHOUT THE ISLANDS. ACTIVITIES TO BE PERFORMED: THIS PROJECT HAS THREE MAIN COMPONENTS. 1) CONDUCT MULTIPLE COMMUNITY OUTREACH AND DESIGN MEETINGS THAT ENGAGE A NETWORK OF APPROXIMATELY 40 FISHPOND MANAGERS AND COMMUNITY-SERVICE ORGANIZATIONS TO GATHER INSIGHTS AND PERSPECTIVES RELATING TO THE MOST IMPORTANT ENVIRONMENTAL, CLIMATE, OR TECHNOLOGICAL BARRIERS TO EFFECTIVE FISHPOND RESTORATION FOR FOOD PRODUCTION. THIS PROCESS WILL HELP TO INFORM DEVELOPMENT OF ENVIRONMENTAL SENSORS. 2) DESIGN, DEVELOP AND DEPLOY ENVIRONMENTAL SENSORS TH

SBIR PHASE I: REAL-TIME DECISION MAKING SOFTWARE FOR WASTEWATER TREATMENT OPERATORS

PURPLE MAI'A FOUNDATION (PMF) WILL ADVANCE ENVIRONMENTAL EDUCATION AND STEWARDSHIP IN HAWAII BY DEVELOPING AND IMPLEMENTING CURRICULUM ON AQUATIC ECOSYSTEM SERVICES PROVIDED BY NATIVE HAWAIIAN FISHPONDS AND DEPLOYING LOW-COST SENSORS ALONGSIDE TRADITIONAL ECOLOGICAL PRACTICES. PMF WILL TRAIN EDUCATORS ON CURRICULUM IMPLEMENTATION AND USE SENSORS TO MEASURE FISHPOND CONDITIONS. IN ADDITION TO IN-CLASS INSTRUCTION, STUDENTS WILL PARTICIPATE IN EXPERIENTIAL LEARNING ACTIVITIES AT FISHPONDS. THIS AGREEMENT PROVIDES FULL FEDERAL FUNDING IN THE AMOUNT OF $100,000. SEE TERMS AND CONDITIONS. PREAWARD COSTS HAVE BEEN APPROVED BACK TO 08/03/2018.

NSF CONVERGENCE ACCELERATOR WORKSHOP: COASTAL BIOCULTURAL RESTORATION AS A NEXUS FOR INNOVATION

SUPPORT AN EDUCATIONAL PROGRAM TO PROVIDE SOLID SKILLS IN ENGLISH, CROSS-CULTURAL COMMUNICATIONS, AND AWARENESS OF CIVIC PARTICIPATION AND LEADERSHIP TO MAYA GIRLS FROM SOLOLA.

SUPPORT AN EDUCATIONAL PROGRAM TO PROVIDE ENGLISH LANGUAGE TRAINING, CROSS-CULTURAL COMMUNICATIONS, AWARENESS OF CIVIC PARTICIPATION, AND LEADERSHIP TO MAYA GIRLS FROM SOLOLA.

THIS GRANT SUPPORTS THE COSTS INCURRED TO IMPLEMENT MEASURES TO RESPOND TO THE NOVEL CORONAVIRUS 2019 (COVID-19), WHICH MAY INCLUDE WORKPLACE SAFETY, MARKET PIVOTS, RETROFITTING FACILITIES, TRANSPORTATION, WORKER HOUSING, AND MEDICAL EXPENSES. IT PROVIDES NEEDED RELIEF TO THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS FOR THEIR COSTS INCURRED BETWEEN JANUARY 27, 2020, THE DATE UPON WHICH THE PUBLIC HEALTH EMERGENCY WAS DECLARED BY THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICE (HHS) UNDER SECTION 319 OF THE PUBLIC HEALTH SERVICE ACT, AND DECEMBER 31, 2021. BENEFICIARIES INCLUDE THE EMPLOYEES OF THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS.

AWARD TO CONDUCT A YEAR-LONG PROGRAM PROVIDING ENGLISH LANGUAGE AND CIVIC ENGAGEMENT TRAINING TO MIDDLE AND HIGH SCHOOL GIRLS IN SOLOLA.

COVER TRAVEL EXPENSES FOR A US SPEAKER TO CARRY OUT A PROGRAM THAT WILL PROMOTE SOCIAL MARKETING TO FOSTER GENDER INCLUSION AND WOMEN EMPOWERMENT.

DESCRIPTION MASKED FOR PII PURPOSES