Bost Inc

CARB-X

HEAD START FULL YEAR/PART DAY

HEAD START AND EARLY HEAD START

HIV EMERGENCY RELIEF PROJECT GRANTS

NATIONAL EMERGING INFECTIOUS DISEASES LABORATORIES OPERATIONS

HEAD START AND EARLY HEAD START 2015-2016

HIV EMERGENCY RELIEF PROJECT GRANTS

MASSHEAL - REDUCING OVERDOSE DEATHS BY 40% (2019-2023)

HEAD START AND EARLY HEAD START

HEALTH CENTER CLUSTER

BOSTON UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE

NATIONAL EMERGING INFECTIOUS DISEASES LABORATORIES OPERATIONS

PUBLIC HOUSING CAPITAL FUND

BOSTON UNIVERSITY CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND - INSTITUTIONAL PORTION

HEALTH CENTER CLUSTER

EDUCATION STABILIZATION FUND - PHASE 2

NOVEL INSIGHTS INTO OSTEOARTHRITIS, PAIN AND FUNCTION: MOST4 - OVERALL ABSTRACT THE MULTICENTER OSTEOARTHRITIS (MOST) STUDY HAS BEEN A MAJOR SOURCE OF NEW KNOWLEDGE ABOUT THE COURSE OF OA AND FACTORS THAT AFFECT IT, HAVING PUBLISHED OVER 180 ARTICLES RANGING FROM STUDIES OF PAIN AND PAIN SENSITIZATION, TO INVESTIGATIONS OF BIOMECHANICS, TO INQUIRIES INTO STRUCTURAL JOINT PATHOLOGY AS VISUALIZED BY MRI, AND TO STUDIES OF DECLINE IN FUNCTION, BUCKLING AND FALLS, AMONG OTHERS. THE INITIAL COHORT ENROLLED 3026 PARTICIPANTS WITH OR AT RISK OF KNEE OA; A NEW COHORT CONSISTING OF 1525 SUBJECTS WAS RECRUITED AT THE LAST CYCLE (MOST3) WHO WERE SLIGHTLY YOUNGER AND UNLIKELY TO HAVE ADVANCED DISEASE. WE WILL RECRUIT AN ADDITIONAL 150 PARTICIPANTS FROM UNDERREPRESENTED MINORITY GROUPS FOR A TOTAL PROJECTED SAMPLE SIZE OF 2293 IN THIS NEXT CYCLE OF MOST (MOST4). IN ADDITION TO ITS SCIENTIFIC OUTPUT, THE STUDY HAS BEEN REMARKABLE IN RECRUITING AND ENCOURAGING TALENTED YOUNG INVESTIGATORS TO TAKE ON CAREER DEFINING INVESTIGATIONS WITHIN MOST, HAVING SERVED AS THE BASIS FOR 31 CAREER DEVELOPMENT AWARDS. OUR OVERALL GOAL IS TO ADVANCE OUR UNDERSTANDING OF OA AND ITS CONSEQUENCES TO OPEN DOORS TO NEW TREATMENT APPROACHES INCLUDING STRATIFIED APPROACHES TO TREATMENTS. WE WILL USE AN INTEGRATED APPROACH IN THE NEXT CYCLE OF MOST (MOST4) OVERSEEN BY AN ADMINISTRATIVE CORE, INVOLVING A CLINICAL DATA COLLECTION AND MANAGEMENT CORE, ANALYSIS CORE, AND IMAGING CORE, WITH GUIDANCE FROM AN OBSERVATIONAL SAFETY MONITORING BOARD AND INPUT FROM A COMMUNITY ADVISORY BOARD, TO EFFICIENTLY ADDRESS KEY KNOWLEDGE GAPS THROUGH THE CONDUCT OF THREE PROJECTS. OUR SPECIFIC AIMS ARE TO: 1. EVALUATE IMPAIRED EXERCISE-INDUCED HYPOALGESIA (EIH) IN KNEE OA, EVALUATE THE RELATION OF NERVOUS SYSTEM ALTERATIONS TO EIH, AND DETERMINE THE IMPACT OF EIH ON PAIN, FUNCTION, PHYSICAL ACTIVITY, AND FEAR-AVOIDANCE RELATED TO EXERCISE (PROJECT 1); 2. CARRY OUT PROTEOMICS ANALYSIS OF SYNOVIAL FLUID TO DETERMINE NETWORKS OF PROTEINS ASSOCIATED WITH GENERALIZED VS. LOCALIZED OA, PAIN AND DISEASE PROGRESSION (PROJECT 2); 3. DIFFERENTIATE TYPES OF CALCIUM CRYSTALS DEPOSITED IN THE JOINT AND, FOR EACH OF THEM, UNDERSTAND THE CLINICAL AND STRUCTURAL CONSEQUENCES OF CRYSTAL DEPOSITION (PROJECT 3); 4. TAKE ADVANTAGE OF COMPREHENSIVE LONGITUDINAL DATA ALREADY COLLECTED IN MOST TO ADDRESS A WIDE RANGE OF QUESTIONS RELATED TO OA AND ITS IMPACT ON OUTCOMES; 5. BRING A MULTIDISCIPLINARY APPROACH TO BEAR ON THIS COMPLEX DISEASE AND OFFER CAREER DEVELOPMENT OPPORTUNITIES TO INVESTIGATORS INCLUDING PILOT PROJECT GRANTS IN THIS UNDERSTUDIED CONDITION. MOST4 WILL INTRODUCE NEW APPROACHES TO UNDERSTANDING DISEASE AND WILL CONTINUE TO COMPREHENSIVELY ASSESS PAIN, STRUCTURAL, AND FUNCTIONAL OUTCOMES SO THAT THE SPECIFIC EFFECTS OF THE FACTORS PROPOSED IN THE PROJECTS AND OTHER RISK FACTORS CAN BE EXAMINED. THIS WORK WILL PRODUCE NEW ACTIONABLE INSIGHTS REGARDING PAIN, STRUCTURAL DETERIORATION AND FUNCTION LOSS IN KNEE OA.

HEALTH CENTER CLUSTER

NANOSYSTEMS ENGINEERING RESEARCH CENTER FOR DIRECTED MULTISCALE ASSEMBLY OF CELLULAR METAMATERIALS WITH NANOSCALE PRECISION: CELL-MET

HEALTH CENTER CLUSTER

PUBLIC HOUSING CAPITAL FUND

PURPOSE: THE PUBLIC HOUSING CAPITAL FUND PROGRAM (CFP) WAS CREATED BY AN AMENDMENT TO THE 1937 ACT BY THE QUALITY HOUSING AND WORK RESPONSIBILITY ACT (QHWRA) IN 1998 (ADDING SECTION 9(D) TO THE 1937 ACT MERGING PREVIOUS MODERNIZATION AND DEVELOPMENT PROGRAMS). THE CFP PROVIDES FINANCIAL ASSISTANCE IN THE FORM OF GRANTS TO APPROXIMATELY 2,770 PUBLIC HOUSING AGENCIES (PHAS), SERVING NEARLY ONE MILLION UNITS, IN ALL 50 STATES AND TERRITORIES, TO CARRY OUT CAPITAL AND MANAGEMENT ACTIVITIES INCLUDING THOSE LISTED IN SECTION 9(D)(1) OF THE UNITED STATES HOUSING ACT OF 1937 (1937 ACT). THE MAIN PURPOSE OF THE CFP FORMULA GRANT IS TO FUND PUBLIC HOUSING MODERNIZATION, DEVELOPMENT, MANAGEMENT IMPROVEMENTS, AND THE OTHER ELIGIBLE ACTIVITIES DESCRIBED IN 24 CFR PART 905. ADDITIONAL INFORMATION ON THE PUBLIC HOUSING CAPITAL FUND IS LOCATED ON THE OFFICE OF CAPITAL IMPROVEMENTS WEBSITE: OFFICE OF CAPITAL IMPROVEMENTS | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) ADDITIONAL INFORMATION ON PUBLIC HOUSING FUNDING CAN BE FOUND BY ACCESSING THE WEBSITE BELOW AND REVIEWING THE PUBLIC HOUSING DASHBOARD LINKED UNDER THE “DATA DASHBOARD AND ANALYTICS”. PUBLIC HOUSING | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD); ACTIVITIES TO BE PERFORMED: THE PHAS RECEIVE FEDERAL FUNDS FROM THE U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) TO ADMINISTER THE PUBLIC HOUSING FUND. PUBLIC HOUSING CAPITAL FUNDS MAY ONLY BE USED FOR ACTIVITIES THAT ARE DESCRIBED AS ELIGIBLE ACTIVITIES IN 24 CFR 905.200 AND ARE EITHER SPECIFIED IN AN APPROVED 5-YEAR ACTION PLAN OR APPROVED BY HUD FOR EMERGENCY WORK OR WORK NEEDED BECAUSE OF A NON-PRESIDENTIALLY DECLARED NATURAL DISASTER. PUBLIC HOUSING DEVELOPMENT, MODERNIZATION, AND FINANCING ARE THE MAJOR ACTIVITIES TO BE PERFORMED. DEVELOPMENT IS ACTIVITIES AND RELATED COSTS THAT ADD TO (OR SIGNIFICANTLY RECONFIGURE) PUBLIC HOUSING UNITS IN A PHA’S INVENTORY, INCLUDING CONSTRUCTION AND ACQUISITION OF ADDITIONAL PUBLIC HOUSING UNITS, WITH OR WITHOUT REHABILITATION, AND ANY-AND-ALL UNDERTAKINGS NECESSARY FOR PLANNING, DESIGN, FINANCING, LAND ACQUISITION, DEMOLITION, CONSTRUCTION, OR EQUIPMENT OF PUBLIC HOUSING UNITS, AND RELATED BUILDINGS, FACILITIES, AND/OR APPURTENANCES (I.E., NON-DWELLING FACILITIES/SPACES). DEVELOPMENT ALSO INCLUDES ANY MIXED-FINANCE MODERNIZATION, ALL RELEVANT MODERNIZATION USES (OTHER THAN MANAGEMENT IMPROVEMENTS), FINANCING USES, AND DEVELOPMENT OF NON-DWELLING SPACE WHERE SUCH SPACE IS NEEDED TO ADMINISTER, AND IS OF DIRECT BENEFIT TO A PUBLIC HOUSING PROJECT (I.E. HOUSING DEVELOPED, ACQUIRED, OR ASSISTED BY A PHA UNDER THE 1937 ACT, AND THE IMPROVEMENT OF ANY SUCH HOUSING), INCLUDING THE RESIDENTS. FINANCING DEBT AND FINANCING COSTS (E.G., ORIGINATION FEES, INTEREST) INCURRED BY A PHA FOR DEVELOPMENT OR MODERNIZATION OF PUBLIC HOUSING PROJECTS, INCLUDING MIXED-FINANCE DEVELOPMENT, THE CAPITAL FUND FINANCING PROGRAM (CFFP), AND ANY OTHER USE AUTHORIZED UNDER SECTION 30 OF THE 1937 ACT. MODERNIZATION INCLUDES ALL ELIGIBLE ACTIVITIES EXCEPT FOR DEVELOPMENT AND FINANCING. PHYSICAL WORK IS A MAJOR ACTIVITY AND IS WORK THAT IS DONE ON THE PHYSICAL STRUCTURES, SITE, AND GROUNDS OF A PUBLIC HOUSING PROPERTY OR STRUCTURE. MAJOR PHYSICAL ACTIVITIES INCLUDE DEMOLITION, RECONFIGURATION, EMERGENCY ACTIVITIES, ENERGY EFFICIENCY, NON-ROUTINE MAINTENANCE, PLANNED CODE COMPLIANCE, AND VACANCY REDUCTION. THE MEASURABLE OUTCOME OF THIS GRANT IS THAT HUD WILL BE ABLE TO TRACK THE AMOUNT OF DOLLARS SPENT ON IMPROVEMENTS TO THE STRUCTURES, UNITS, COMMON AREAS, UTILITIES, AND OTHER ELIGIBLE ACTIVITIES. ; EXPECTED OUTCOMES: THE EXPECTED OUTCOMES FOR PUBLIC HOUSING CAPITAL FUNDS OF APPROXIMATELY $3.2 BILLION WILL BE PUT INTO THE DEVELOPMENT, MODERNIZATION, AND FINANCING OF NEARLY 1 MILLION PUBLIC HOUSING UNITS ACROSS ALL 50 STATES AND TERRITORIES. THE PUBLIC HOUSING UNITS ARE UPDATED TO BE DECENT, SAFE, SANITARY AND TO COMPLY WITH FEDERAL HOUSING STANDARDS. PHAS CAN ALSO USE A PORTION OF THE CAPITAL FUNDING FOR MANAGEMENT IMPROVEMENTS OR OPERATING ACTIVITIES INCLUDING SAFETY AND SECURITY COSTS.; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES FOR PUBLIC HOUSING CAPITAL FUNDS ARE THE LOW-INCOME PUBLIC HOUSING RESIDENTS.; SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

PUBLIC HOUSING CAPITAL FUND

PURPOSE: THE PUBLIC HOUSING CAPITAL FUND PROGRAM (CFP) WAS CREATED BY AN AMENDMENT TO THE 1937 ACT BY THE QUALITY HOUSING AND WORK RESPONSIBILITY ACT (QHWRA) IN 1998 (ADDING SECTION 9(D) TO THE 1937 ACT MERGING PREVIOUS MODERNIZATION AND DEVELOPMENT PROGRAMS). THE CFP PROVIDES FINANCIAL ASSISTANCE IN THE FORM OF GRANTS TO APPROXIMATELY 2,770 PUBLIC HOUSING AGENCIES (PHAS), SERVING NEARLY ONE MILLION UNITS, IN ALL 50 STATES AND TERRITORIES, TO CARRY OUT CAPITAL AND MANAGEMENT ACTIVITIES INCLUDING THOSE LISTED IN SECTION 9(D)(1) OF THE UNITED STATES HOUSING ACT OF 1937 (1937 ACT). THE MAIN PURPOSE OF THE CFP FORMULA GRANT IS TO FUND PUBLIC HOUSING MODERNIZATION, DEVELOPMENT, MANAGEMENT IMPROVEMENTS, AND THE OTHER ELIGIBLE ACTIVITIES DESCRIBED IN 24 CFR PART 905. ADDITIONAL INFORMATION ON THE PUBLIC HOUSING CAPITAL FUND IS LOCATED ON THE OFFICE OF CAPITAL IMPROVEMENTS WEBSITE: OFFICE OF CAPITAL IMPROVEMENTS | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) ADDITIONAL INFORMATION ON PUBLIC HOUSING FUNDING CAN BE FOUND BY ACCESSING THE WEBSITE BELOW AND REVIEWING THE PUBLIC HOUSING DASHBOARD LINKED UNDER THE “DATA DASHBOARD AND ANALYTICS”. PUBLIC HOUSING | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD); ACTIVITIES TO BE PERFORMED: THE PHAS RECEIVE FEDERAL FUNDS FROM THE U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) TO ADMINISTER THE PUBLIC HOUSING FUND. PUBLIC HOUSING CAPITAL FUNDS MAY ONLY BE USED FOR ACTIVITIES THAT ARE DESCRIBED AS ELIGIBLE ACTIVITIES IN 24 CFR 905.200 AND ARE EITHER SPECIFIED IN AN APPROVED 5-YEAR ACTION PLAN OR APPROVED BY HUD FOR EMERGENCY WORK OR WORK NEEDED BECAUSE OF A NON-PRESIDENTIALLY DECLARED NATURAL DISASTER. PUBLIC HOUSING DEVELOPMENT, MODERNIZATION, AND FINANCING ARE THE MAJOR ACTIVITIES TO BE PERFORMED. DEVELOPMENT IS ACTIVITIES AND RELATED COSTS THAT ADD TO (OR SIGNIFICANTLY RECONFIGURE) PUBLIC HOUSING UNITS IN A PHA’S INVENTORY, INCLUDING CONSTRUCTION AND ACQUISITION OF ADDITIONAL PUBLIC HOUSING UNITS, WITH OR WITHOUT REHABILITATION, AND ANY-AND-ALL UNDERTAKINGS NECESSARY FOR PLANNING, DESIGN, FINANCING, LAND ACQUISITION, DEMOLITION, CONSTRUCTION, OR EQUIPMENT OF PUBLIC HOUSING UNITS, AND RELATED BUILDINGS, FACILITIES, AND/OR APPURTENANCES (I.E., NON-DWELLING FACILITIES/SPACES). DEVELOPMENT ALSO INCLUDES ANY MIXED-FINANCE MODERNIZATION, ALL RELEVANT MODERNIZATION USES (OTHER THAN MANAGEMENT IMPROVEMENTS), FINANCING USES, AND DEVELOPMENT OF NON-DWELLING SPACE WHERE SUCH SPACE IS NEEDED TO ADMINISTER, AND IS OF DIRECT BENEFIT TO A PUBLIC HOUSING PROJECT (I.E. HOUSING DEVELOPED, ACQUIRED, OR ASSISTED BY A PHA UNDER THE 1937 ACT, AND THE IMPROVEMENT OF ANY SUCH HOUSING), INCLUDING THE RESIDENTS. FINANCING DEBT AND FINANCING COSTS (E.G., ORIGINATION FEES, INTEREST) INCURRED BY A PHA FOR DEVELOPMENT OR MODERNIZATION OF PUBLIC HOUSING PROJECTS, INCLUDING MIXED-FINANCE DEVELOPMENT, THE CAPITAL FUND FINANCING PROGRAM (CFFP), AND ANY OTHER USE AUTHORIZED UNDER SECTION 30 OF THE 1937 ACT. MODERNIZATION INCLUDES ALL ELIGIBLE ACTIVITIES EXCEPT FOR DEVELOPMENT AND FINANCING. PHYSICAL WORK IS A MAJOR ACTIVITY AND IS WORK THAT IS DONE ON THE PHYSICAL STRUCTURES, SITE, AND GROUNDS OF A PUBLIC HOUSING PROPERTY OR STRUCTURE. MAJOR PHYSICAL ACTIVITIES INCLUDE DEMOLITION, RECONFIGURATION, EMERGENCY ACTIVITIES, ENERGY EFFICIENCY, NON-ROUTINE MAINTENANCE, PLANNED CODE COMPLIANCE, AND VACANCY REDUCTION. THE MEASURABLE OUTCOME OF THIS GRANT IS THAT HUD WILL BE ABLE TO TRACK THE AMOUNT OF DOLLARS SPENT ON IMPROVEMENTS TO THE STRUCTURES, UNITS, COMMON AREAS, UTILITIES, AND OTHER ELIGIBLE ACTIVITIES. ; EXPECTED OUTCOMES: THE EXPECTED OUTCOMES FOR PUBLIC HOUSING CAPITAL FUNDS OF APPROXIMATELY $3.2 BILLION WILL BE PUT INTO THE DEVELOPMENT, MODERNIZATION, AND FINANCING OF NEARLY 1 MILLION PUBLIC HOUSING UNITS ACROSS ALL 50 STATES AND TERRITORIES. THE PUBLIC HOUSING UNITS ARE UPDATED TO BE DECENT, SAFE, SANITARY AND TO COMPLY WITH FEDERAL HOUSING STANDARDS. PHAS CAN ALSO USE A PORTION OF THE CAPITAL FUNDING FOR MANAGEMENT IMPROVEMENTS OR OPERATING ACTIVITIES INCLUDING SAFETY AND SECURITY COSTS.; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES FOR PUBLIC HOUSING CAPITAL FUNDS ARE THE LOW-INCOME PUBLIC HOUSING RESIDENTS.; SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

PURPOSE: THE PUBLIC HOUSING CAPITAL FUND PROGRAM (CFP) WAS CREATED BY AN AMENDMENT TO THE 1937 ACT BY THE QUALITY HOUSING AND WORK RESPONSIBILITY ACT (QHWRA) IN 1998 (ADDING SECTION 9(D) TO THE 1937 ACT MERGING PREVIOUS MODERNIZATION AND DEVELOPMENT PROGRAMS). THE CFP PROVIDES FINANCIAL ASSISTANCE IN THE FORM OF GRANTS TO APPROXIMATELY 2,770 PUBLIC HOUSING AGENCIES (PHAS), SERVING NEARLY ONE MILLION UNITS, IN ALL 50 STATES AND TERRITORIES, TO CARRY OUT CAPITAL AND MANAGEMENT ACTIVITIES INCLUDING THOSE LISTED IN SECTION 9(D)(1) OF THE UNITED STATES HOUSING ACT OF 1937 (1937 ACT). THE MAIN PURPOSE OF THE CFP FORMULA GRANT IS TO FUND PUBLIC HOUSING MODERNIZATION, DEVELOPMENT, MANAGEMENT IMPROVEMENTS, AND THE OTHER ELIGIBLE ACTIVITIES DESCRIBED IN 24 CFR PART 905. ADDITIONAL INFORMATION ON THE PUBLIC HOUSING CAPITAL FUND IS LOCATED ON THE OFFICE OF CAPITAL IMPROVEMENTS WEBSITE: OFFICE OF CAPITAL IMPROVEMENTS | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) ADDITIONAL INFORMATION ON PUBLIC HOUSING FUNDING CAN BE FOUND BY ACCESSING THE WEBSITE BELOW AND REVIEWING THE PUBLIC HOUSING DASHBOARD LINKED UNDER THE “DATA DASHBOARD AND ANALYTICS”. PUBLIC HOUSING | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD); ACTIVITIES TO BE PERFORMED: THE PHAS RECEIVE FEDERAL FUNDS FROM THE U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) TO ADMINISTER THE PUBLIC HOUSING FUND. PUBLIC HOUSING CAPITAL FUNDS MAY ONLY BE USED FOR ACTIVITIES THAT ARE DESCRIBED AS ELIGIBLE ACTIVITIES IN 24 CFR 905.200 AND ARE EITHER SPECIFIED IN AN APPROVED 5-YEAR ACTION PLAN OR APPROVED BY HUD FOR EMERGENCY WORK OR WORK NEEDED BECAUSE OF A NON-PRESIDENTIALLY DECLARED NATURAL DISASTER. PUBLIC HOUSING DEVELOPMENT, MODERNIZATION, AND FINANCING ARE THE MAJOR ACTIVITIES TO BE PERFORMED. DEVELOPMENT IS ACTIVITIES AND RELATED COSTS THAT ADD TO (OR SIGNIFICANTLY RECONFIGURE) PUBLIC HOUSING UNITS IN A PHA’S INVENTORY, INCLUDING CONSTRUCTION AND ACQUISITION OF ADDITIONAL PUBLIC HOUSING UNITS, WITH OR WITHOUT REHABILITATION, AND ANY-AND-ALL UNDERTAKINGS NECESSARY FOR PLANNING, DESIGN, FINANCING, LAND ACQUISITION, DEMOLITION, CONSTRUCTION, OR EQUIPMENT OF PUBLIC HOUSING UNITS, AND RELATED BUILDINGS, FACILITIES, AND/OR APPURTENANCES (I.E., NON-DWELLING FACILITIES/SPACES). DEVELOPMENT ALSO INCLUDES ANY MIXED-FINANCE MODERNIZATION, ALL RELEVANT MODERNIZATION USES (OTHER THAN MANAGEMENT IMPROVEMENTS), FINANCING USES, AND DEVELOPMENT OF NON-DWELLING SPACE WHERE SUCH SPACE IS NEEDED TO ADMINISTER, AND IS OF DIRECT BENEFIT TO A PUBLIC HOUSING PROJECT (I.E. HOUSING DEVELOPED, ACQUIRED, OR ASSISTED BY A PHA UNDER THE 1937 ACT, AND THE IMPROVEMENT OF ANY SUCH HOUSING), INCLUDING THE RESIDENTS. FINANCING DEBT AND FINANCING COSTS (E.G., ORIGINATION FEES, INTEREST) INCURRED BY A PHA FOR DEVELOPMENT OR MODERNIZATION OF PUBLIC HOUSING PROJECTS, INCLUDING MIXED-FINANCE DEVELOPMENT, THE CAPITAL FUND FINANCING PROGRAM (CFFP), AND ANY OTHER USE AUTHORIZED UNDER SECTION 30 OF THE 1937 ACT. MODERNIZATION INCLUDES ALL ELIGIBLE ACTIVITIES EXCEPT FOR DEVELOPMENT AND FINANCING. PHYSICAL WORK IS A MAJOR ACTIVITY AND IS WORK THAT IS DONE ON THE PHYSICAL STRUCTURES, SITE, AND GROUNDS OF A PUBLIC HOUSING PROPERTY OR STRUCTURE. MAJOR PHYSICAL ACTIVITIES INCLUDE DEMOLITION, RECONFIGURATION, EMERGENCY ACTIVITIES, ENERGY EFFICIENCY, NON-ROUTINE MAINTENANCE, PLANNED CODE COMPLIANCE, AND VACANCY REDUCTION. THE MEASURABLE OUTCOME OF THIS GRANT IS THAT HUD WILL BE ABLE TO TRACK THE AMOUNT OF DOLLARS SPENT ON IMPROVEMENTS TO THE STRUCTURES, UNITS, COMMON AREAS, UTILITIES, AND OTHER ELIGIBLE ACTIVITIES. ; EXPECTED OUTCOMES: THE EXPECTED OUTCOMES FOR PUBLIC HOUSING CAPITAL FUNDS OF APPROXIMATELY $3.2 BILLION WILL BE PUT INTO THE DEVELOPMENT, MODERNIZATION, AND FINANCING OF NEARLY 1 MILLION PUBLIC HOUSING UNITS ACROSS ALL 50 STATES AND TERRITORIES. THE PUBLIC HOUSING UNITS ARE UPDATED TO BE DECENT, SAFE, SANITARY AND TO COMPLY WITH FEDERAL HOUSING STANDARDS. PHAS CAN ALSO USE A PORTION OF THE CAPITAL FUNDING FOR MANAGEMENT IMPROVEMENTS OR OPERATING ACTIVITIES INCLUDING SAFETY AND SECURITY COSTS.; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES FOR PUBLIC HOUSING CAPITAL FUNDS ARE THE LOW-INCOME PUBLIC HOUSING RESIDENTS.; SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

BOSTON UNIVERSITY CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND - STUDENT AID

HEALTH CENTER CLUSTER

HEALTH CENTER CLUSTER

DESCRIPTION:THE AGREEMENT PROVIDES FUNDING UNDER THE INFLATION REDUCTION ACT (IRA) TO CITY OF BOSTON, BOSTON PUBLIC SCHOOLS TO REPLACE IN-USE, NON-ZERO-EMISSION HEAVY-DUTY VEHICLES WITH NEW ZERO-EMISSION VEHICLES TO REDUCE AIR POLLUTION AND GREENHOUSE GAS EMISSIONS IN EPA REGION 1. THE RECIPIENT WILL REPLACE 125 ELIGIBLE VEHICLES WITH COMPARABLE, ELIGIBLE ZERO-EMISSION VEHICLES UNDER THE SCHOOL BUS SUB-PROGRAM, RESULTING IN CLEANER AIR AND IMPROVED HEALTH FOR COMMUNITIES IN BOSTON, MASSACHUSETTS. ACTIVITIES:THE ACTIVITIES INCLUDE REPLACING ELIGIBLE INTERNAL COMBUSTION ENGINE CLASS 7 VEHICLES WITH ELIGIBLE ZERO-EMISSION VEHICLES; PURCHASING, INSTALLING, OPERATING, AND MAINTAINING CHARGING EQUIPMENT TO MAINTAIN THE NEW ZERO-EMISSION VEHICLES; AND PROVIDING WORKFORCE DEVELOPMENT AND TRAINING TO SUPPORT THE MAINTENANCE, CHARGING, AND OPERATION OF THE NEW ZERO-EMISSION VEHICLES. SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE REPLACING 125 HEAVY-DUTY DIESEL AND PROPANE SCHOOL BUSES WITH ZERO-EMISSION BUSES AND INSTALLING 125 LEVEL 3 CHARGERS. THREE TRAINING SESSIONS WILL BE PROVIDED TO STAFF, DRIVERS, AND MECHANICS ABOUT HOW TO PROPERLY OPERATE AND MAINTAIN THE ZERO-ELECTRIC BUSES AND CHARGERS, AND COMMUNITY ENGAGEMENT ACTIVITIES WILL BE HELD TO CONNECT WITH AND EDUCATE THE COMMUNITY. THE EXPECTED OUTCOMES INCLUDE STRENGTHENED CAPACITY FOR ELECTRIFICATION AND TRANSPORTATION PLANNING, INCREASED CHARGING CAPACITY FOR HEAVY-DUTY FLEET, REDUCED GREENHOUSE GAS AND CRITERIA POLLUTANT EMISSIONS, REDUCED FUEL CONSUMPTION, IMPROVED AIR QUALITY, TRAINED STAFF, AND INCREASED PUBLIC AWARENESS AND UNDERSTANDING ABOUT THE ENVIRONMENTAL AND ECONOMIC EFFECTIVENESS OF THE IMPLEMENTED TECHNOLOGY. THE INTENDED BENEFICIARIES INCLUDE THE BOSTON PUBLIC SCHOOL DISTRICT (GRANTEE). OTHER BENEFICIARIES INCLUDE DISADVANTAGED COMMUNITY RESIDENTS WHO WILL BENEFIT FROM IMPROVED AMBIENT AIR QUALITY IN COMMUNITIES IN WHICH THE VEHICLES OPERATE.

CAPITAL AND MANAGEMENT ACTIVITIES (FORMULA)

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

PUBLIC HOUSING CAPITAL FUND

CHOICE NEIGHBORHOODS IMPLEMENTATION GRANTS

BIPARTISAN INFRASTRUCTURE LAW (BIL) - CHAMPION: CHROMIUM ATR METALLURGY WITH PLASMA MELTING AND HOT ISOSTATIC PRESSING OF NEAR-NET-SHAPE HIGH-TEMPERATURE ALLOY PARTS

PRECISION MONITORING AND ASSESSMENT IN THE FRAMINGHAM STUDY: COGNITIVE, MRI, GENETIC AND BIOMARKER PRECURSORS OF AD & DEMENTIA

PUBLIC HOUSING CAPITAL FUND

EMERGENCY SOLUTIONS GRANT PROGRAM

PUBLIC HOUSING CAPITAL FUND

PUBLIC HOUSING CAPITAL FUND

SUPERFUND BASIC RESEARCH PROGRAM AT BOSTON UNIVERSITY

DETECTION OF EARLY LUNG CANCER AMONG MILITARY PERSONNEL

CAPITAL FUND PROGRAM

CAPITAL FUND PROGRAM

PHOTONICS RESEARCH AND TECHNOLOGY

CAPITAL FUND PROGRAM

UMASS BOSTON-DF/HCC U54 PARTNERSHIP (2 OF 2)

STAFFING FOR ADEQUATE FIRE AND EMERGENCY RESPONSE (SAFER)

A PROPOSAL TO SUPPORT DISTRICT-LEVEL IMPLEMENTATION OF THE ZAMBIA MINISTRY OF HEA

A FOLLOW-UP STUDY FOR CAUSES OF CANCER IN BLACK WOMEN

RESILIENCE/RESISTANCE TO ALZHEIMER'S DISEASE IN CENTENARIANS AND OFFSPRING (RADCO) - PROJECT SUMMARY/ABSTRACT THE NIA FUNDED PARENT PROJECT, 1U19AG073172, “RESILIENCE/RESISTANCE TO ALZHEIMER’S DISEASE IN CENTENARIANS AND THEIR OFFSPRING (RADCO)” SEEKS TO CHARACTERIZE COGNITIVE RESILIENCE OR BRAIN RESISTANCE TO AD AND TO DISCOVER THE UNDERLYING AND HOPEFULLY TRANSLATABLE BIOLOGICAL MECHANISMS THAT ENABLE CENTENARIAN COGNITIVE SUPERAGERS TO MAINTAIN COGNITIVE FUNCTION TYPICAL OF COGNITIVELY INTACT SEPTUAGENARIANS. TO ADDRESS REVIEWERS’ CONCERNS THAT AFRICAN AMERICANS (N=88 OR 7.2%) ARE UNDERREPRESENTED IN THE RADCO SAMPLE AND THAT TOO FEW CENTENARIANS (N=75 OR 15% OF THE TOTAL NEUROIMAGED SAMPLE) UNDERGO NEUROIMAGING, THIS ADMINISTRATIVE SUPPLEMENT APPLICATION SEEKS TO FUND A FOURTH PHENOTYPING AND BIOSPECIMEN CORE AND NEUROIMAGING CORE SITE AT GEORGIA STATE UNIVERSITY (GSU). THE GSU SITE WILL ENHANCE THE DIVERSITY OF THE RADCO COHORT BY ENROLLING 234 AFRICAN AMERICANS, THUS INCREASING THE PROPORTION OF THE RADCO SAMPLE THAT IS AFRICAN AMERICAN FROM 7.2% (88/1216) TO 22.2% (322/1450). GSU IS ALSO ABLE TO BE A FOURTH NEUROIMAGING SITE FOR RADCO AS IT HAS A PRISMA MRI PLATFORM AND ROUTINELY PERFORMS THE KEY STRUCTURAL AND RESTING STATE FUNCTIONAL PULSE SEQUENCES THAT ARE IDENTICAL TO THOSE USED BY THE THREE CURRENT NEUROIMAGING CENTERS OF THE NEUROIMAGING CORE AS WELL AS THE HUMAN CONNECTOME-AGING PROJECT. WE ANTICIPATE THAT ABOUT HALF (N=103) OF THE ATLANTA-BASED PARTICIPANTS WILL UNDERGO NEUROIMAGING. OF THESE 103 ADDITIONAL NEUROIMAGED PARTICIPANTS, WE ESTIMATE 44 WILL BE CENTENARIANS. THESE 44 CENTENARIANS ADDED TO THE RADCO-WIDE SAMPLE OF 150 CENTENARIANS WILL BRING THE PROPORTION OF CENTENARIANS WHO ARE NEUROIMAGED TO 34% (194/573). DR. VONETTA DOTSON’S EXPERTISE AND DEMONSTRATED SUCCESS IN ENGAGING THE LOCAL AFRICAN AMERICAN COMMUNITY FOR ENROLLMENT IN RESEARCH STUDIES PROVIDES RADCO WITH THE OPPORTUNITY TO SUBSTANTIALLY INCREASE OUR AFRICAN AMERICAN PARTICIPANT ENROLLMENT THAT WILL PROVIDE AN ADEQUATELY POWERED SAMPLE TO DISCERN RACE-SPECIFIC DIFFERENCES AND SIMILARITIES IN DETERMINANTS OR MARKERS OF COGNITIVE SUPERAGING. THE CONDUCT OF THIS AFRICAN AMERICAN PARTICIPANT ENROLLMENT EFFORT AT GSU PROVIDES THE ADDED BENEFIT AND RARE OPPORTUNITY TO COLLABORATE WITH THE GEORGIA STATE/GEORGIA TECH CENTER FOR ADVANCED BRAIN IMAGING (CABI), LED BY VINCE CALHOUN, TO INCREASE OUR SAMPLE OF PARTICIPANTS UNDERGOING THE RIGOROUSLY STANDARDIZED NEUROIMAGING COMPONENT OF THE STUDY.

IN PARTNERSHIP WITH OVER 100 LOCAL EMPLOYERS, INCLUDING MASS GENERAL BRIGHAM AND THE ALLIANCE OF MASSACHUSETTS YMCAS, EDIC WILL CREATE DEMAND-DRIVEN PATHWAYS INTO QUALITY CHILDCARE, HEALTHCARE, AND ENERGY JOBS. ITS CHILDCARE SECTORAL PARTNERSHIP, LED BY COMMUNITY ADVOCATES FOR YOUNG LEARNERS (CAYL) INSTITUTE, WILL DEVELOP A PIPELINE OF LICENSED CHILDCARE PROFESSIONALS AS A NOTABLE STRATEGY TO BOLSTER THE CARE ECONOMY IN THE REGION. ITS HEALTHCARE SECTOR PARTNERSHIP, LED BY THE BOSTON HEALTHCARE CAREERS CONSORTIUM (HCC), WILL BUILD OFF THE PROMINENCE OF THE LOCAL HEALTH INDUSTRY TO PLACE TALENT INTO HEALTHCARE CAREERS WITH ADVANCEMENT OPPORTUNITIES. ITS CLEAN ENERGY SECTOR PARTNERSHIP, LED BY BENJAMIN FRANKLIN INSTITUTE OF TECHNOLOGY, AN ASIAN AMERICAN AND NATIVE AMERICAN PACIFIC ISLANDER-SERVING INSTITUTION, WILL PARTNER WITH LOCAL UNIONS TO DEVELOP SKILLED JOURNEYMEN WORKERS TO DEVELOP CLEAN ENERGY INFRASTRUCTURE. TOGETHER, THESE PARTNERSHIPS PROJECT TO PLACE THOUSANDS OF LOCAL BOSTON RESIDENTS, WITH A FOCUS ON COMMUNITIES OF COLOR AND WOMEN, INTO WELL-PAYING JOBS IN THREE INDUSTRIES THAT ARE CRUCIAL TO THE REGION'S FUTURE GROWTH AND PROSPERITY.

CAPITAL FUND RECOVERY ACT (COMPETITIVE)

URBAN REVITALIZATION

HOME INVESTMENT PARTNERSHIPS PROGRAM

HEALTH CENTER CLUSTER

CAPITAL FUND PROGRAM

ENTITLED CITIES

SR-04 EXTENSIONS

SR-07 EXTENSIONS

HEALTHY START INITIATIVE

SEVERELY DISTRESSED PUBLIC HSN

DESCRIPTION:THIS AGREEMENT PROVIDES FUNDING UNDER THE INFRASTRUCTURE INVESTMENT AND JOBS ACT (IIJA) TO THE CITY OF BOSTON (BOSTON PUBLIC SCHOOLS). THIS AGREEMENT IS TO REPLACE EXISTING SCHOOL BUSES WITH CLEAN AND ZERO EMISSION (ZE) SCHOOL BUSES. ACTIVITIES:THE ACTIVITIES INCLUDE REPLACING FIFTY (50) CLASS 7 DIESEL SCHOOL BUSES WITH FIFTY (50) CLASS 7 ELECTRIC SCHOOL BUSES AND FIFTY (50) DIRECT CURRENT (DC) FAST CHARGING INFRASTRUCTURE. THE NEW SCHOOL BUSES WILL SERVE THE BOSTON PUBLIC SCHOOLS (BPS) SCHOOL DISTRICT. SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE: - PUBLIC ENGAGEMENT VIA PUBLIC MEETINGS TO ENGAGE AFFECTED COMMUNITIES BEFORE AND AFTER DEPLOYMENT, PUBLIC COMMENT EMAIL INBOX, AND TWO PUBLIC SURVEYS ON ELECTRIC SCHOOL BUSES (ESBS) TO GAGE ATTITUDES, IMPACT, AND FEEDBACK - CONSTRUCTION BUILDOUT OF SUPPORTING INFRASTRUCTURE TO CHARGE ELECTRIC SCHOOL BUSES (ONE TRANSFORMER, TWO SWITCHGEAR, AND 300+ FEET OF CONDUIT INSTALLED, FIFTY 30 KILOWATT (KW) OR HIGHER DIRECT CURRENT FAST CHARGERS (DCFC) INSTALLED) - FIFTY DIESEL BUSES TRANSITIONED TO ELECTRIC - 6,500 SCHOOL CHILDREN NOW SERVED BY A ZERO EMISSION (ZE) SCHOOL BUS - 40% OF VEHICLE MILES TRAVELED ARE IN ENVIRONMENTAL JUSTICE (EJ) NEIGHBORHOODS TRANSITIONED TO ZE BUSES - REDUCED AIR POLLUTION BY 0.042 SHORT TONS OF PARTICULATE MATTER (PM2.5), AND 687.9 SHORT TONS OF CARBON DIOXIDE (CO2). - WORKFORCE DEVELOPMENT VIA TRAINING SESSIONS FOR EACH KEY OPERATIONS TEAM, COACHING FOR DRIVERS, TRAINING FOR NEW DRIVERS, ONBOARDING MECHANICS AND OPERATIONS STAFF TO SUPPORT BUS ROLL OUT, TRAINING FOR FIRE DISTRICT'S FIRST RESPONDERS TO RESPOND TO ESBS, AND TRAINING FOR BUS ROUTERS. - SHARE LESSONS LEARNED VIA VIRTUAL AND IN-PERSON ENGAGEMENTS TO DISSEMINATE BEST PRACTICE, LESSONS LEARNED ABOUT THE TECHNOLOGY AND ITS US, AND TO SHARE INFORMATION WITH INTERESTED FLEETS ADDRESSING LARGE SCALE COLD WEATHER ESB DEPLOYMENT THE EXPECTED OUTCOMES INCLUDE: - INCREASED PUBLIC AWARENESS OF PROJECT AND RESULTS AND INCREASED PUBLIC EXPOSURE TO ELECTRIC VEHICLE (EV) TECHNOLOGY - STRENGTHENED CAPACITY FOR ELECTRIFICATION AND TRANSPORTATION PLANNING IN BPS DEPARTMENT OF TRANSPORTATION (DOT) - IMPROVED AMBIENT AIR QUALITY AROUND BUS YARD, EJ NEIGHBORHOODS, AND BROADER CITY -IMPROVED HEALTH FOR LOCAL SCHOOL CHILDREN, FEWER OF WHOM ARE EXPOSED TO DIESEL EXHAUST EMISSIONS - GROWTH OF WORKFORCE TO SUPPORT ZERO EMISSION VEHICLES AND KEY COMPONENTS LIKE BATTERIES - INCREASED KNOWLEDGE OF SUCCESSFUL USE OF INVOLVED TECHNOLOGIES - INCREASED UNDERSTANDING OF THE ENVIRONMENTAL AND ECONOMIC EFFECTIVENESS OF ESBS IN THE COMMUNITY THE INTENDED BENEFICIARIES INCLUDE BOSTON PUBLIC SCHOOLS (BPS); BPS STUDENTS, TEACHERS, AND STAFF; AND THE GREATER BOSTON COMMUNITY.

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

URBAN REVITALIZATION

ENTITLED CITIES

ENTITLED CITIES

BOSTON UNIVERSITY ALZHEIMER'S DISEASE CORE CENTER

CELEST: A CENTER OF EXCELLENCE FOR LEARNING IN EDUCATION SCIENCE AND TECHNOLOGY

CARES ACT: EMERGENCY RELIEF FUND INSTITUTIONAL PORTION

STC: CENTER FOR INTEGRATED SPACE WEATHER MODELING

PUBLIC HOUSING CAPITAL FUND

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

BOSTON UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD (CTSA) PROGRAM UL1

PURPOSE: THE COMMUNITY DEVELOPMENT BLOCK GRANT (CDBG) PROGRAM PROVIDES ANNUAL GRANTS ON A FORMULA BASIS TO STATES, CITIES, AND COUNTIES TO DEVELOP VIABLE URBAN COMMUNITIES BY PROVIDING DECENT HOUSING AND A SUITABLE LIVING ENVIRONMENT, AND BY EXPANDING ECONOMIC OPPORTUNITIES, PRINCIPALLY FOR LOW- AND MODERATE-INCOME PERSONS. THE PROGRAM IS AUTHORIZED UNDER TITLE 1 OF THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974, PUBLIC LAW 93-383, AS AMENDED 42 U.S.C. 5301 ET SEQ. THE CDBG PROGRAM COVERS FOUR DISTINCT PROGRAMS, EACH WITH THEIR OWN SET OF GOVERNING REGULATIONS: CDBG ENTITLEMENT, CDBG NON-ENTITLED COUNTIES IN HAWAII, CDBG INSULAR AREAS, AND STATE CDBG. IN THE CDBG ENTITLEMENT PROGRAM, HUD AWARDS GRANTS TO ENTITLEMENT COMMUNITY GRANTEES TO CARRY OUT A WIDE RANGE OF COMMUNITY DEVELOPMENT ACTIVITIES. ENTITLEMENT COMMUNITIES DEVELOP THEIR OWN PROGRAMS AND FUNDING PRIORITIES. IN THE CDBG NON-ENTITLED COUNTIES IN HAWAII PROGRAM, THREE COUNTIES QUALIFY: HAWAII, KAUAI, AND MAUI. THE FY 2004 APPROPRIATIONS ACT REQUIRED THE GOVERNOR OF HAWAII TO DECIDE IF THE STATE WISHED TO PARTICIPATE IN THE STATE CDBG PROGRAM BY JULY 31, 2004. THE STATE MADE THE DECISION NOT TO PARTICIPATE IN THE PROGRAM. AS A RESULT OF THIS DECISION HUD'S HONOLULU FIELD OFFICE ADMINISTERS THE NON-ENTITLED GRANTS IN HAWAII. FUNDS ARE ALLOCATED USING A FORMULA BASED ON POPULATION, POVERTY, AND HOUSING OVERCROWDING, WITH THE POVERTY FACTOR CARRYING A DOUBLE WEIGHT. FOR THE CDBG INSULAR AREAS PROGRAM, HUD ANNUALLY ALLOCATES CDBG GRANTS TO FOUR DESIGNATED AREAS: AMERICAN SAMOA; GUAM; NORTHERN MARIANA ISLANDS; AND THE U.S. VIRGIN ISLANDS. THE FUNDS ARE ALLOCATED IN PROPORTION TO THE POPULATIONS OF THE ELIGIBLE TERRITORIES. THE PROGRAM IS ADMINISTERED BY HUD'S FIELD OFFICES IN PUERTO RICO AND HAWAII. UNDER THE STATE CDBG PROGRAM, STATES PASS THROUGH CDBG GRANTS TO UNITS OF GENERAL LOCAL GOVERNMENT. ANNUALLY, EACH STATE DEVELOPS FUNDING PRIORITIES AND CRITERIA FOR SELECTING PROJECTS. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS. NON-ENTITLEMENT AREAS INCLUDE THOSE UNITS OF GENERAL LOCAL GOVERNMENT WHICH DO NOT RECEIVE CDBG FUNDS DIRECTLY FROM HUD. GENERALLY, NON-ENTITLEMENT AREAS ARE CITIES WITH POPULATIONS OF LESS THAN 50,000 (EXCEPT CITIES THAT ARE DESIGNATED PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS), AND COUNTIES WITH POPULATIONS OF LESS THAN 200,000. CURRENT CDBG AWARDS AND ALLOCATIONS ARE INCLUDED IN THIS LIST OF HUD COMMUNITY PLANNING AND DEVELOPMENT (CPD) AWARDS AND ALLOCATIONS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/ALLOCATIONS-AWARDS/; ACTIVITIES TO BE PERFORMED: CDBG FUNDS MAY BE USED FOR ACTIVITIES WHICH INCLUDE, BUT ARE NOT LIMITED TO: ACQUISITION OF REAL PROPERTY; RELOCATION AND DEMOLITION; REHABILITATION OF RESIDENTIAL AND NON-RESIDENTIAL STRUCTURES; CONSTRUCTION OF PUBLIC FACILITIES AND IMPROVEMENTS, SUCH AS WATER AND SEWER FACILITIES, STREETS, NEIGHBORHOOD CENTERS, AND THE CONVERSION OF SCHOOL BUILDINGS FOR ELIGIBLE PURPOSES; PUBLIC SERVICES, WITHIN CERTAIN LIMITS; ACTIVITIES RELATING TO ENERGY CONSERVATION AND RENEWABLE ENERGY RESOURCES; PROVISION OF ASSISTANCE TO PROFIT-MOTIVATED BUSINESSES TO CARRY OUT ECONOMIC DEVELOPMENT AND JOB CREATION/RETENTION ACTIVITIES. EACH ACTIVITY MUST MEET ONE OF THE FOLLOWING NATIONAL OBJECTIVES FOR THE PROGRAM: BENEFIT LOW- AND MODERATE-INCOME PERSONS, PREVENTION OR ELIMINATION OF SLUMS OR BLIGHT, OR ADDRESS COMMUNITY DEVELOPMENT NEEDS HAVING A PARTICULAR URGENCY BECAUSE EXISTING CONDITIONS POSE A SERIOUS AND IMMEDIATE THREAT TO THE HEALTH OR WELFARE OF THE COMMUNITY FOR WHICH OTHER FUNDING IS NOT AVAILABLE. GENERALLY, THE FOLLOWING TYPES OF ACTIVITIES ARE INELIGIBLE: ACQUISITION, CONSTRUCTION, OR RECONSTRUCTION OF BUILDINGS FOR THE GENERAL CONDUCT OF GOVERNMENT; POLITICAL ACTIVITIES; CERTAIN INCOME PAYMENTS; CONSTRUCTION OF NEW HOUSING (WITH SOME EXCEPTIONS). UNDER THE STATE CDBG PROGRAM, STATES MAY USE $100,000 PLUS UP TO A MAXIMUM OF THREE PERCENT OF ITS CDBG ALLOCATION. AMOUNTS EXPENDED ON ADMINISTRATION IN EXCESS OF $100,000 MUST BE MATCHED. STATES MAY EXPEND UP TO THREE PERCENT OF THEIR CDBG ALLOCATION ON TECHNICAL ASSISTANCE ACTIVITIES. HOWEVER, THE TOTAL A STATE SPENDS ON BOTH ADMINISTRATIVE AND TECHNICAL ASSISTANCE EXPENSES MAY NOT EXCEED $100,000 PLUS THREE PERCENT OF THE STATE'S ALLOCATION. CPD HAS DEVELOPED PROFILES THAT DISPLAY GRANTEE-REPORTED ACCOMPLISHMENTS FOR SELECTED HOUSING, ECONOMIC DEVELOPMENT, PUBLIC IMPROVEMENT, AND PUBLIC SERVICE ACTIVITIES. PROFILES FOR GRANTEES WILL VARY, AS GRANTEES HAVE FLEXIBILITY IN DETERMINING THE HOUSING, ECONOMIC, AND COMMUNITY DEVELOPMENT ACTIVITIES THEY CARRY OUT WITH CDBG FUNDS. THE MOST RECENT ACCOMPLISHMENTS CAN BE VIEWED WITHIN THE NATIONAL ACCOMPLISHMENT REPORTS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/CDBG/CDBG-ACCOMPLISHMENT-REPORTS/; EXPECTED OUTCOMES: THE CDBG PROGRAM REINFORCES SEVERAL IMPORTANT VALUES AND PRINCIPLES OF COMMUNITY DEVELOPMENT: PROGRAM FLEXIBILITY TO EMPOWER PEOPLE AND COMMUNITIES TO DESIGN AND IMPLEMENT STRATEGIES TAILORED TO THEIR OWN NEEDS AND PRIORITIES; AN EMPHASIS ON CONSOLIDATED PLANNING THAT EXPANDS AND STRENGTHENS PARTNERSHIPS AMONG ALL LEVELS OF GOVERNMENT AND THE PRIVATE SECTOR IN ENHANCING COMMUNITY DEVELOPMENT; TECHNICAL ASSISTANCE ACTIVITIES AND SET-ASIDE FOR GRANTEES TO BUILD THE CAPACITY OF THESE PARTNERS. EACH CDBG GRANTEE’S EXPECTED OUTCOMES ARE DESCRIBED AS GOALS IN THEIR CONSOLIDATED PLAN. THE MOST RECENT CONSOLIDATED PLANS CAN BE VIEWED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/REPORTS/#CONSOLIDATED-PLANS-ANNUAL-ACTION-PLANS-AND-CAPERS; INTENDED BENEFICIARIES: OVER A 1, 2, OR 3-YEAR PERIOD, AS SELECTED BY THE GRANTEE, NOT LESS THAN 70 PERCENT OF CDBG FUNDS MUST BE USED FOR ACTIVITIES THAT BENEFIT LOW- AND MODERATE-INCOME PERSONS. HUD DOES NOT PROVIDE CDBG ASSISTANCE DIRECTLY TO INDIVIDUALS, BUSINESSES, NONPROFIT OR ORGANIZATIONS OR OTHER NON-GOVERNMENTAL ENTITIES. INDIVIDUALS WHO ARE INTERESTED IN PARTICIPATING IN THIS PROGRAM, SHOULD CONTACT THEIR LOCAL MUNICIPAL OR COUNTY OFFICIALS TO FIND OUT HOW THE PROGRAM OPERATES IN THEIR COMMUNITY. PARTICIPATION REQUIREMENTS MAY DIFFER FROM ONE GRANTEE TO ANOTHER. WITH THE EXCEPTION OF THE STATE CDBG PROGRAM, THE LOCAL GOVERNMENT GRANTEE ADMINISTERS THE CDBG PROGRAM AND DETERMINES WHICH LOCAL PROJECTS RECEIVE FUNDING. ELIGIBLE GRANTEES ARE AS FOLLOWS: PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS (MSAS); OTHER METROPOLITAN CITIES WITH POPULATIONS OF AT LEAST 50,000; QUALIFIED URBAN COUNTIES WITH POPULATIONS OF AT LEAST 200,000 (EXCLUDING THE POPULATION OF ENTITLED CITIES); STATES AND INSULAR AREAS. THE DISTRICT OF COLUMBIA IS FUNDED UNDER THE CDBG ENTITLEMENT PROGRAM. THE STATE OF HAWAII DOES NOT PARTICIPATE, AND HUD ALLOCATES THE STATE'S SHARE OF FUNDS TO THE THREE HAWAII NON-ENTITLED COUNTIES. THE STATES ADMINISTER CDBG FUNDS IN THE STATE CDBG PROGRAM. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

ENTITLED CITIES

SR-04 EXTENSIONS

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

PUBLIC HOUSING CAPITAL FUND

BOSTON OBESITY RESEARCH CENTER

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

PURPOSE: THE COMMUNITY DEVELOPMENT BLOCK GRANT (CDBG) PROGRAM PROVIDES ANNUAL GRANTS ON A FORMULA BASIS TO STATES, CITIES, AND COUNTIES TO DEVELOP VIABLE URBAN COMMUNITIES BY PROVIDING DECENT HOUSING AND A SUITABLE LIVING ENVIRONMENT, AND BY EXPANDING ECONOMIC OPPORTUNITIES, PRINCIPALLY FOR LOW- AND MODERATE-INCOME PERSONS. THE PROGRAM IS AUTHORIZED UNDER TITLE 1 OF THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974, PUBLIC LAW 93-383, AS AMENDED 42 U.S.C. 5301 ET SEQ. THE CDBG PROGRAM COVERS FOUR DISTINCT PROGRAMS, EACH WITH THEIR OWN SET OF GOVERNING REGULATIONS: CDBG ENTITLEMENT, CDBG NON-ENTITLED COUNTIES IN HAWAII, CDBG INSULAR AREAS, AND STATE CDBG. IN THE CDBG ENTITLEMENT PROGRAM, HUD AWARDS GRANTS TO ENTITLEMENT COMMUNITY GRANTEES TO CARRY OUT A WIDE RANGE OF COMMUNITY DEVELOPMENT ACTIVITIES. ENTITLEMENT COMMUNITIES DEVELOP THEIR OWN PROGRAMS AND FUNDING PRIORITIES. IN THE CDBG NON-ENTITLED COUNTIES IN HAWAII PROGRAM, THREE COUNTIES QUALIFY: HAWAII, KAUAI, AND MAUI. THE FY 2004 APPROPRIATIONS ACT REQUIRED THE GOVERNOR OF HAWAII TO DECIDE IF THE STATE WISHED TO PARTICIPATE IN THE STATE CDBG PROGRAM BY JULY 31, 2004. THE STATE MADE THE DECISION NOT TO PARTICIPATE IN THE PROGRAM. AS A RESULT OF THIS DECISION HUD'S HONOLULU FIELD OFFICE ADMINISTERS THE NON-ENTITLED GRANTS IN HAWAII. FUNDS ARE ALLOCATED USING A FORMULA BASED ON POPULATION, POVERTY, AND HOUSING OVERCROWDING, WITH THE POVERTY FACTOR CARRYING A DOUBLE WEIGHT. FOR THE CDBG INSULAR AREAS PROGRAM, HUD ANNUALLY ALLOCATES CDBG GRANTS TO FOUR DESIGNATED AREAS: AMERICAN SAMOA; GUAM; NORTHERN MARIANA ISLANDS; AND THE U.S. VIRGIN ISLANDS. THE FUNDS ARE ALLOCATED IN PROPORTION TO THE POPULATIONS OF THE ELIGIBLE TERRITORIES. THE PROGRAM IS ADMINISTERED BY HUD'S FIELD OFFICES IN PUERTO RICO AND HAWAII. UNDER THE STATE CDBG PROGRAM, STATES PASS THROUGH CDBG GRANTS TO UNITS OF GENERAL LOCAL GOVERNMENT. ANNUALLY, EACH STATE DEVELOPS FUNDING PRIORITIES AND CRITERIA FOR SELECTING PROJECTS. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS. NON-ENTITLEMENT AREAS INCLUDE THOSE UNITS OF GENERAL LOCAL GOVERNMENT WHICH DO NOT RECEIVE CDBG FUNDS DIRECTLY FROM HUD. GENERALLY, NON-ENTITLEMENT AREAS ARE CITIES WITH POPULATIONS OF LESS THAN 50,000 (EXCEPT CITIES THAT ARE DESIGNATED PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS), AND COUNTIES WITH POPULATIONS OF LESS THAN 200,000. CURRENT CDBG AWARDS AND ALLOCATIONS ARE INCLUDED IN THIS LIST OF HUD COMMUNITY PLANNING AND DEVELOPMENT (CPD) AWARDS AND ALLOCATIONS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/ALLOCATIONS-AWARDS/; ACTIVITIES TO BE PERFORMED: CDBG FUNDS MAY BE USED FOR ACTIVITIES WHICH INCLUDE, BUT ARE NOT LIMITED TO: ACQUISITION OF REAL PROPERTY; RELOCATION AND DEMOLITION; REHABILITATION OF RESIDENTIAL AND NON-RESIDENTIAL STRUCTURES; CONSTRUCTION OF PUBLIC FACILITIES AND IMPROVEMENTS, SUCH AS WATER AND SEWER FACILITIES, STREETS, NEIGHBORHOOD CENTERS, AND THE CONVERSION OF SCHOOL BUILDINGS FOR ELIGIBLE PURPOSES; PUBLIC SERVICES, WITHIN CERTAIN LIMITS; ACTIVITIES RELATING TO ENERGY CONSERVATION AND RENEWABLE ENERGY RESOURCES; PROVISION OF ASSISTANCE TO PROFIT-MOTIVATED BUSINESSES TO CARRY OUT ECONOMIC DEVELOPMENT AND JOB CREATION/RETENTION ACTIVITIES. EACH ACTIVITY MUST MEET ONE OF THE FOLLOWING NATIONAL OBJECTIVES FOR THE PROGRAM: BENEFIT LOW- AND MODERATE-INCOME PERSONS, PREVENTION OR ELIMINATION OF SLUMS OR BLIGHT, OR ADDRESS COMMUNITY DEVELOPMENT NEEDS HAVING A PARTICULAR URGENCY BECAUSE EXISTING CONDITIONS POSE A SERIOUS AND IMMEDIATE THREAT TO THE HEALTH OR WELFARE OF THE COMMUNITY FOR WHICH OTHER FUNDING IS NOT AVAILABLE. GENERALLY, THE FOLLOWING TYPES OF ACTIVITIES ARE INELIGIBLE: ACQUISITION, CONSTRUCTION, OR RECONSTRUCTION OF BUILDINGS FOR THE GENERAL CONDUCT OF GOVERNMENT; POLITICAL ACTIVITIES; CERTAIN INCOME PAYMENTS; CONSTRUCTION OF NEW HOUSING (WITH SOME EXCEPTIONS). UNDER THE STATE CDBG PROGRAM, STATES MAY USE $100,000 PLUS UP TO A MAXIMUM OF THREE PERCENT OF ITS CDBG ALLOCATION. AMOUNTS EXPENDED ON ADMINISTRATION IN EXCESS OF $100,000 MUST BE MATCHED. STATES MAY EXPEND UP TO THREE PERCENT OF THEIR CDBG ALLOCATION ON TECHNICAL ASSISTANCE ACTIVITIES. HOWEVER, THE TOTAL A STATE SPENDS ON BOTH ADMINISTRATIVE AND TECHNICAL ASSISTANCE EXPENSES MAY NOT EXCEED $100,000 PLUS THREE PERCENT OF THE STATE'S ALLOCATION. CPD HAS DEVELOPED PROFILES THAT DISPLAY GRANTEE-REPORTED ACCOMPLISHMENTS FOR SELECTED HOUSING, ECONOMIC DEVELOPMENT, PUBLIC IMPROVEMENT, AND PUBLIC SERVICE ACTIVITIES. PROFILES FOR GRANTEES WILL VARY, AS GRANTEES HAVE FLEXIBILITY IN DETERMINING THE HOUSING, ECONOMIC, AND COMMUNITY DEVELOPMENT ACTIVITIES THEY CARRY OUT WITH CDBG FUNDS. THE MOST RECENT ACCOMPLISHMENTS CAN BE VIEWED WITHIN THE NATIONAL ACCOMPLISHMENT REPORTS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/CDBG/CDBG-ACCOMPLISHMENT-REPORTS/; EXPECTED OUTCOMES: THE CDBG PROGRAM REINFORCES SEVERAL IMPORTANT VALUES AND PRINCIPLES OF COMMUNITY DEVELOPMENT: PROGRAM FLEXIBILITY TO EMPOWER PEOPLE AND COMMUNITIES TO DESIGN AND IMPLEMENT STRATEGIES TAILORED TO THEIR OWN NEEDS AND PRIORITIES; AN EMPHASIS ON CONSOLIDATED PLANNING THAT EXPANDS AND STRENGTHENS PARTNERSHIPS AMONG ALL LEVELS OF GOVERNMENT AND THE PRIVATE SECTOR IN ENHANCING COMMUNITY DEVELOPMENT; TECHNICAL ASSISTANCE ACTIVITIES AND SET-ASIDE FOR GRANTEES TO BUILD THE CAPACITY OF THESE PARTNERS. EACH CDBG GRANTEE’S EXPECTED OUTCOMES ARE DESCRIBED AS GOALS IN THEIR CONSOLIDATED PLAN. THE MOST RECENT CONSOLIDATED PLANS CAN BE VIEWED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/REPORTS/#CONSOLIDATED-PLANS-ANNUAL-ACTION-PLANS-AND-CAPERS; INTENDED BENEFICIARIES: OVER A 1, 2, OR 3-YEAR PERIOD, AS SELECTED BY THE GRANTEE, NOT LESS THAN 70 PERCENT OF CDBG FUNDS MUST BE USED FOR ACTIVITIES THAT BENEFIT LOW- AND MODERATE-INCOME PERSONS. HUD DOES NOT PROVIDE CDBG ASSISTANCE DIRECTLY TO INDIVIDUALS, BUSINESSES, NONPROFIT OR ORGANIZATIONS OR OTHER NON-GOVERNMENTAL ENTITIES. INDIVIDUALS WHO ARE INTERESTED IN PARTICIPATING IN THIS PROGRAM, SHOULD CONTACT THEIR LOCAL MUNICIPAL OR COUNTY OFFICIALS TO FIND OUT HOW THE PROGRAM OPERATES IN THEIR COMMUNITY. PARTICIPATION REQUIREMENTS MAY DIFFER FROM ONE GRANTEE TO ANOTHER. WITH THE EXCEPTION OF THE STATE CDBG PROGRAM, THE LOCAL GOVERNMENT GRANTEE ADMINISTERS THE CDBG PROGRAM AND DETERMINES WHICH LOCAL PROJECTS RECEIVE FUNDING. ELIGIBLE GRANTEES ARE AS FOLLOWS: PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS (MSAS); OTHER METROPOLITAN CITIES WITH POPULATIONS OF AT LEAST 50,000; QUALIFIED URBAN COUNTIES WITH POPULATIONS OF AT LEAST 200,000 (EXCLUDING THE POPULATION OF ENTITLED CITIES); STATES AND INSULAR AREAS. THE DISTRICT OF COLUMBIA IS FUNDED UNDER THE CDBG ENTITLEMENT PROGRAM. THE STATE OF HAWAII DOES NOT PARTICIPATE, AND HUD ALLOCATES THE STATE'S SHARE OF FUNDS TO THE THREE HAWAII NON-ENTITLED COUNTIES. THE STATES ADMINISTER CDBG FUNDS IN THE STATE CDBG PROGRAM. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

ENDING THE HIV EPIDEMIC: A PLAN FOR AMERICA ? RYAN WHITE HIV/AIDS PROGRAM PARTS A AND B

TOPICS IN PARTICLE PHYSICS.

CAPITAL FUND PROGRAM

CAPITAL FUND PROGRAM

CAPITAL FUND PROGRAM

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

CHRONIC TRAUMATIC ENCEPHALOPATHY: DETECTION, DIAGNOSIS, COURSE, AND RISK FACTORS

PURPOSE: THE COMMUNITY DEVELOPMENT BLOCK GRANT (CDBG) PROGRAM PROVIDES ANNUAL GRANTS ON A FORMULA BASIS TO STATES, CITIES, AND COUNTIES TO DEVELOP VIABLE URBAN COMMUNITIES BY PROVIDING DECENT HOUSING AND A SUITABLE LIVING ENVIRONMENT, AND BY EXPANDING ECONOMIC OPPORTUNITIES, PRINCIPALLY FOR LOW- AND MODERATE-INCOME PERSONS. THE PROGRAM IS AUTHORIZED UNDER TITLE 1 OF THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974, PUBLIC LAW 93-383, AS AMENDED 42 U.S.C. 5301 ET SEQ. THE CDBG PROGRAM COVERS FOUR DISTINCT PROGRAMS, EACH WITH THEIR OWN SET OF GOVERNING REGULATIONS: CDBG ENTITLEMENT, CDBG NON-ENTITLED COUNTIES IN HAWAII, CDBG INSULAR AREAS, AND STATE CDBG. IN THE CDBG ENTITLEMENT PROGRAM, HUD AWARDS GRANTS TO ENTITLEMENT COMMUNITY GRANTEES TO CARRY OUT A WIDE RANGE OF COMMUNITY DEVELOPMENT ACTIVITIES. ENTITLEMENT COMMUNITIES DEVELOP THEIR OWN PROGRAMS AND FUNDING PRIORITIES. IN THE CDBG NON-ENTITLED COUNTIES IN HAWAII PROGRAM, THREE COUNTIES QUALIFY: HAWAII, KAUAI, AND MAUI. THE FY 2004 APPROPRIATIONS ACT REQUIRED THE GOVERNOR OF HAWAII TO DECIDE IF THE STATE WISHED TO PARTICIPATE IN THE STATE CDBG PROGRAM BY JULY 31, 2004. THE STATE MADE THE DECISION NOT TO PARTICIPATE IN THE PROGRAM. AS A RESULT OF THIS DECISION HUD'S HONOLULU FIELD OFFICE ADMINISTERS THE NON-ENTITLED GRANTS IN HAWAII. FUNDS ARE ALLOCATED USING A FORMULA BASED ON POPULATION, POVERTY, AND HOUSING OVERCROWDING, WITH THE POVERTY FACTOR CARRYING A DOUBLE WEIGHT. FOR THE CDBG INSULAR AREAS PROGRAM, HUD ANNUALLY ALLOCATES CDBG GRANTS TO FOUR DESIGNATED AREAS: AMERICAN SAMOA; GUAM; NORTHERN MARIANA ISLANDS; AND THE U.S. VIRGIN ISLANDS. THE FUNDS ARE ALLOCATED IN PROPORTION TO THE POPULATIONS OF THE ELIGIBLE TERRITORIES. THE PROGRAM IS ADMINISTERED BY HUD'S FIELD OFFICES IN PUERTO RICO AND HAWAII. UNDER THE STATE CDBG PROGRAM, STATES PASS THROUGH CDBG GRANTS TO UNITS OF GENERAL LOCAL GOVERNMENT. ANNUALLY, EACH STATE DEVELOPS FUNDING PRIORITIES AND CRITERIA FOR SELECTING PROJECTS. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS. NON-ENTITLEMENT AREAS INCLUDE THOSE UNITS OF GENERAL LOCAL GOVERNMENT WHICH DO NOT RECEIVE CDBG FUNDS DIRECTLY FROM HUD. GENERALLY, NON-ENTITLEMENT AREAS ARE CITIES WITH POPULATIONS OF LESS THAN 50,000 (EXCEPT CITIES THAT ARE DESIGNATED PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS), AND COUNTIES WITH POPULATIONS OF LESS THAN 200,000. CURRENT CDBG AWARDS AND ALLOCATIONS ARE INCLUDED IN THIS LIST OF HUD COMMUNITY PLANNING AND DEVELOPMENT (CPD) AWARDS AND ALLOCATIONS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/ALLOCATIONS-AWARDS/; ACTIVITIES TO BE PERFORMED: CDBG FUNDS MAY BE USED FOR ACTIVITIES WHICH INCLUDE, BUT ARE NOT LIMITED TO: ACQUISITION OF REAL PROPERTY; RELOCATION AND DEMOLITION; REHABILITATION OF RESIDENTIAL AND NON-RESIDENTIAL STRUCTURES; CONSTRUCTION OF PUBLIC FACILITIES AND IMPROVEMENTS, SUCH AS WATER AND SEWER FACILITIES, STREETS, NEIGHBORHOOD CENTERS, AND THE CONVERSION OF SCHOOL BUILDINGS FOR ELIGIBLE PURPOSES; PUBLIC SERVICES, WITHIN CERTAIN LIMITS; ACTIVITIES RELATING TO ENERGY CONSERVATION AND RENEWABLE ENERGY RESOURCES; PROVISION OF ASSISTANCE TO PROFIT-MOTIVATED BUSINESSES TO CARRY OUT ECONOMIC DEVELOPMENT AND JOB CREATION/RETENTION ACTIVITIES. EACH ACTIVITY MUST MEET ONE OF THE FOLLOWING NATIONAL OBJECTIVES FOR THE PROGRAM: BENEFIT LOW- AND MODERATE-INCOME PERSONS, PREVENTION OR ELIMINATION OF SLUMS OR BLIGHT, OR ADDRESS COMMUNITY DEVELOPMENT NEEDS HAVING A PARTICULAR URGENCY BECAUSE EXISTING CONDITIONS POSE A SERIOUS AND IMMEDIATE THREAT TO THE HEALTH OR WELFARE OF THE COMMUNITY FOR WHICH OTHER FUNDING IS NOT AVAILABLE. GENERALLY, THE FOLLOWING TYPES OF ACTIVITIES ARE INELIGIBLE: ACQUISITION, CONSTRUCTION, OR RECONSTRUCTION OF BUILDINGS FOR THE GENERAL CONDUCT OF GOVERNMENT; POLITICAL ACTIVITIES; CERTAIN INCOME PAYMENTS; CONSTRUCTION OF NEW HOUSING (WITH SOME EXCEPTIONS). UNDER THE STATE CDBG PROGRAM, STATES MAY USE $100,000 PLUS UP TO A MAXIMUM OF THREE PERCENT OF ITS CDBG ALLOCATION. AMOUNTS EXPENDED ON ADMINISTRATION IN EXCESS OF $100,000 MUST BE MATCHED. STATES MAY EXPEND UP TO THREE PERCENT OF THEIR CDBG ALLOCATION ON TECHNICAL ASSISTANCE ACTIVITIES. HOWEVER, THE TOTAL A STATE SPENDS ON BOTH ADMINISTRATIVE AND TECHNICAL ASSISTANCE EXPENSES MAY NOT EXCEED $100,000 PLUS THREE PERCENT OF THE STATE'S ALLOCATION. CPD HAS DEVELOPED PROFILES THAT DISPLAY GRANTEE-REPORTED ACCOMPLISHMENTS FOR SELECTED HOUSING, ECONOMIC DEVELOPMENT, PUBLIC IMPROVEMENT, AND PUBLIC SERVICE ACTIVITIES. PROFILES FOR GRANTEES WILL VARY, AS GRANTEES HAVE FLEXIBILITY IN DETERMINING THE HOUSING, ECONOMIC, AND COMMUNITY DEVELOPMENT ACTIVITIES THEY CARRY OUT WITH CDBG FUNDS. THE MOST RECENT ACCOMPLISHMENTS CAN BE VIEWED WITHIN THE NATIONAL ACCOMPLISHMENT REPORTS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/CDBG/CDBG-ACCOMPLISHMENT-REPORTS/; EXPECTED OUTCOMES: THE CDBG PROGRAM REINFORCES SEVERAL IMPORTANT VALUES AND PRINCIPLES OF COMMUNITY DEVELOPMENT: PROGRAM FLEXIBILITY TO EMPOWER PEOPLE AND COMMUNITIES TO DESIGN AND IMPLEMENT STRATEGIES TAILORED TO THEIR OWN NEEDS AND PRIORITIES; AN EMPHASIS ON CONSOLIDATED PLANNING THAT EXPANDS AND STRENGTHENS PARTNERSHIPS AMONG ALL LEVELS OF GOVERNMENT AND THE PRIVATE SECTOR IN ENHANCING COMMUNITY DEVELOPMENT; TECHNICAL ASSISTANCE ACTIVITIES AND SET-ASIDE FOR GRANTEES TO BUILD THE CAPACITY OF THESE PARTNERS. EACH CDBG GRANTEE’S EXPECTED OUTCOMES ARE DESCRIBED AS GOALS IN THEIR CONSOLIDATED PLAN. THE MOST RECENT CONSOLIDATED PLANS CAN BE VIEWED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/REPORTS/#CONSOLIDATED-PLANS-ANNUAL-ACTION-PLANS-AND-CAPERS; INTENDED BENEFICIARIES: OVER A 1, 2, OR 3-YEAR PERIOD, AS SELECTED BY THE GRANTEE, NOT LESS THAN 70 PERCENT OF CDBG FUNDS MUST BE USED FOR ACTIVITIES THAT BENEFIT LOW- AND MODERATE-INCOME PERSONS. HUD DOES NOT PROVIDE CDBG ASSISTANCE DIRECTLY TO INDIVIDUALS, BUSINESSES, NONPROFIT OR ORGANIZATIONS OR OTHER NON-GOVERNMENTAL ENTITIES. INDIVIDUALS WHO ARE INTERESTED IN PARTICIPATING IN THIS PROGRAM, SHOULD CONTACT THEIR LOCAL MUNICIPAL OR COUNTY OFFICIALS TO FIND OUT HOW THE PROGRAM OPERATES IN THEIR COMMUNITY. PARTICIPATION REQUIREMENTS MAY DIFFER FROM ONE GRANTEE TO ANOTHER. WITH THE EXCEPTION OF THE STATE CDBG PROGRAM, THE LOCAL GOVERNMENT GRANTEE ADMINISTERS THE CDBG PROGRAM AND DETERMINES WHICH LOCAL PROJECTS RECEIVE FUNDING. ELIGIBLE GRANTEES ARE AS FOLLOWS: PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS (MSAS); OTHER METROPOLITAN CITIES WITH POPULATIONS OF AT LEAST 50,000; QUALIFIED URBAN COUNTIES WITH POPULATIONS OF AT LEAST 200,000 (EXCLUDING THE POPULATION OF ENTITLED CITIES); STATES AND INSULAR AREAS. THE DISTRICT OF COLUMBIA IS FUNDED UNDER THE CDBG ENTITLEMENT PROGRAM. THE STATE OF HAWAII DOES NOT PARTICIPATE, AND HUD ALLOCATES THE STATE'S SHARE OF FUNDS TO THE THREE HAWAII NON-ENTITLED COUNTIES. THE STATES ADMINISTER CDBG FUNDS IN THE STATE CDBG PROGRAM. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

ENTITLED CITIES

CENTER FOR RESEARCH TO EVALUATE & ELIMINATE DENTAL DISPARITIES

ENTITLED CITIES

IDENTIFYING PROTECTIVE OMICS PROFILES IN CENTENARIANS AND TRANSLATING THESE INTO PREVENTIVE AND THERAPEUTIC STRATEGIES - PROJECT ABSTRACT. CENTENARIANS (AGES >100 YRS) AND EVEN MORE-SO, SEMI-SUPERCENTENARIANS (AGES 105-109 YRS) AND SUPERCENTENARIANS (110+ YRS) ARE OUTLIERS NOT ONLY FOR THEIR EXCEPTIONALLY LONG LIFESPANS, BUT ALSO FOR THEIR LONGER FEMALE FERTILITY AND RESISTANCE TO AGING-RELATED DISABILITY AND MORBIDITIES SUCH AS ALZHEIMER’S DISEASE, HEART DISEASE, STROKE, DIABETES AND CANCER. THEIR OFFSPRING ALSO EXHIBIT DELAYED MORBIDITY AND LOWER MORTALITY COMPARED TO THEIR BIRTH COHORT. AMONG NON-HUMAN SPECIES, RODENTS INCLUDING THE NAKED MOLE RAT HAVE ALSO GAINED ATTENTION FOR THEIR VARIATION IN LIFESPAN COMPARED TO OTHER MAMMALS WITH SIMILAR BODY MASS. PROTEOMIC SIGNATURES ASSOCIATED WITH EXTREME LONGEVITY (EL) IN CENTENARIANS AND INTEGRATED TRANSCRIPTOMIC AND PROTEOMIC DATA IN NMRS SUGGEST THAT INTEGRATED ANALYSES OF MULTIPLE OMICS DATA GENERATED FROM THESE HUMAN AND ANIMAL MODELS OF SLOW AGING AND RESISTANCE TO AGING RELATED DISEASES CAN INFORM US ABOUT BIOLOGICAL MECHANISMS THAT UNDERLIE THESE SURVIVAL AND HEALTH ADVANTAGES AND, ULTIMATELY, ABOUT POTENTIAL THERAPEUTICS TO PREVENT DISEASES SUCH AS ALZHEIMER’S. TWO SPECIFIC AIMS PARALLEL THE UH2 AND UH3 PHASES OF THIS PROPOSAL. AIM 1: IN THE UH2 PHASE, THE NEW ENGLAND CENTENARIAN STUDY AND THE EINSTEIN CENTENARIAN AND OFFSPRING STUDIES WILL ESTABLISH A STANDARDIZED PHENOTYPIC DATA AND BIOLOGICAL SAMPLE COLLECTION PROTOCOL FOR IN-PERSON VISITS OF 700 SUBJECTS FROM EACH STUDY (N=1400). DETAILED COGNITIVE FUNCTION TESTING WILL DETERMINE PRESENCE OR ABSENCE OF PROBABLE ALZHEIMER’S. THE PHENOTYPING PROTOCOL WILL BE THE SAME AS THAT USED BY THE LONGEVITY CONSORTIUM’S CENTENARIAN PROJECT (N=350), SO THAT THEIR DATA CAN BE ADDED TO THIS EFFORT FOR A TOTAL SAMPLE OF 1,750. A WORLD-CLASS MULTIDISCIPLINARY TEAM WILL PLAN THE MULTI-OMICS DATA GENERATION AND ANALYTIC AND TRANSLATION EFFORTS TO BE EXECUTED IN AIM 2. THESE EFFORTS WILL BE PARALLELED BY COMPARATIVE TRANSCRIPTOMIC, PROTEOMIC AND MICROBIOMIC STUDIES OF NON-HUMAN MAMMALIAN SPECIES OF WIDELY DIFFERENT LIFE SPANS AND BY THE CREATION OF A LIBRARY OF EL-SPECIFIC IPSCS THAT WILL BE DIFFERENTIATED INTO UNLIMITED NUMBERS OF HEPATOCYTES AND NEURONS. AIM 2: IN THE UH3 PHASE, WE WILL GENERATE TRANSCRIPTOMIC, METHYLOMICS, METABOLOMICS, PROTEOMIC AND MICROBIOMIC DATA FROM CENTENARIANS AND CENTENARIAN OFFSPRING (GENERATED FROM TWO TIME POINTS IN ABOUT A THIRD OF THE SAMPLE). METHODS FOR MULTI-OMIC DATA INTEGRATION COMPILED IN AIM 1 WILL BE USED TO DISCOVER MOLECULAR PROFILES THAT ASSOCIATE WITH EL AND HEALTHY AGING PHENOTYPES INCLUDING DELAY OF OR ESCAPE FROM ALZHEIMER’S DISEASE. INTEGRATION WITH MOLECULAR PROFILES FROM FUNCTIONAL STUDIES OF RESILIENCY PERFORMED WITH IPSC-DERIVED NEURONS AND HEPATOCYTES AND WITH MOLECULAR PROFILES ASSOCIATED WITH INCREASED LIFESPAN FROM MULTIPLE SPECIES WILL POINT TO MECHANISMS AND GENERATE CANDIDATE SMALL MOLECULE AND COMPOUND THERAPEUTICS. ALL GENERATED DATA AND UNIQUE BIOLOGICAL RESOURCES, INCLUDING THE EL- IPSC DERIVED HEPATOCYTES AND NEURONS, WILL BE SHARED WITH CONSORTIA AND INDIVIDUAL INVESTIGATORS RESEARCHING ALZHEIMER’S, OTHER AGING RELATED DISEASES AND MORE GENERALLY, BASIC MECHANISMS OF AGING.

BIOLOGY OF THE LUNG: A MULTIDISCIPLINARY PROGRAM

BOSTON UNIVERSITY ALZHEIMER'S DISEASE RESEARCH CENTER - THE BOSTON UNIVERSITY ALZHEIMER'S DISEASE RESEARCH CENTER (BU ADRC) IS COMMITTED TO THE GOALS AND STRATEGIES OF NAPA INCLUDING: TO PREVENT AND EFFECTIVELY TREAT AD AND AD RELATED DEMENTIAS (ADRD) BY 2025 BY EXPANDING AD/ADRD RESEARCH; TO ACCELERATE EFFORTS TO IDENTIFY EARLY AND PRE-SYMPTOMATIC STAGES OF AD/ADRD; AND TO EDUCATE THE PUBLIC ABOUT AD/ADRD. BU ADRC RESEARCH THEMES ARE CONGRUENT WITH NIH AD/ADRD RESEARCH SUMMIT RECOMMENDATIONS INCLUDING: 1) RESEARCH ON HETEROGENEITY AND THE MULTIFACTORIAL NATURE OF AD/ADRD; 2) MOLECULAR PROFILING OF EXISTING AND NEW COHORTS; AND 3) DEVELOPING NEW PUBLIC-PRIVATE PARTNERSHIPS. WE OPERATIONALIZE OUR MISSION THROUGH 7 TIGHTLY INTEGRATED CORES: ADMINISTRATIVE, CLINICAL (CC), DATA MANAGEMENT AND STATISTICS (DMS), BIOMARKER, NEUROPATHOLOGY (NPC), OUTREACH/RECRUITMENT, ENGAGEMENT (ORE), GENETICS AND MOLECULAR PROFILING (GMP) AND A RESEARCH EDUCATION COMPONENT (REC). THE CORES ARE FOCUSED ON CUTTING EDGE RESEARCH, PROACTIVE COMMUNITY ENGAGEMENT, TRAINING THE NEXT GENERATION OF AD/ADRD CLINICIANS AND RESEARCHERS, AND SHARING KEY MATERIAL, DATA, AND EXPERTISE BOTH AMONG KEY PARTNERS AND WITH THE COMMUNITY AT LARGE. THE BU ADRC HAS MADE SIGNIFICANT CONTRIBUTIONS TO THE REMARKABLE GROWTH OF AD/ADRD RESEARCH NATIONALLY AND HAS ACTIVELY CONTRIBUTED PARTICIPANTS, BIOLOGICAL SAMPLES, CLINICAL DATA, AND SCIENTIFIC EXPERTISE TO ALL MAJOR NATIONAL AD/ADRD RESEARCH INITIATIVES. THE BU ADRC HAS BEEN THE CATALYST FOR EXCITING NEW RESEARCH ON GENETIC AND LIFESPAN ENVIRONMENTAL RISK FACTORS AND AD/ADRD, PARTICULARLY VASCULAR RISK AND EXPOSURE TO REPETITIVE HEAD IMPACTS (RHI) FROM CONTACT SPORTS, MILITARY SERVICE AND OTHER SOURCES. MAJOR BU ADRC RESEARCH THEMES INCLUDE STUDIES ON RHI FROM CONTACT SPORTS AND MILITARY SERVICE AND RISK FOR AD/ADRD, INCLUDING CHRONIC TRAUMATIC ENCEPHALOPATHY (CTE) AND DEEP PHENOTYPING AD/ADRD HETEROGENEITY WITH A RANGE OF COMPLEMENTARY INNOVATIVE APPROACHES INCLUDING DIGITAL AND EEG PHENOTYPING; NEUROPATHOLOGY; GENETICS; BIOSTATISTICAL MODELLING; BIOMARKER DISCOVERY; AND MOLECULAR PROFILING. THE BU ADRC WILL BUILD ON THIS STRONG RECORD OF ACCOMPLISHMENT TO SUPPORT NEW RESEARCH AND EDUCATE THE NEXT GENERATION OF AD/ADRD SCIENTISTS. THE BU ADRC WILL ALSO SUPPORT HIGH RISK HIGH GAIN INNOVATIVE DEVELOPMENTAL PROJECTS FOCUSED ON NAPA AND NIA STRATEGIC GOALS AND UTILIZE OUR COLLECTIVE EXPERTISE AND EXPERIENCE TO FACILITATE CAREER DEVELOPMENT OF INVESTIGATORS WITH DIVERSE BACKGROUNDS. THE BU ADRC WILL DEVELOP NEW PARTNERSHIPS AND ENHANCE CURRENT PARTNERSHIPS WITH OTHER ADRCS AND NATIONAL RESEARCH PROGRAMS, FOUNDATIONS, ADVOCACY GROUPS AND PRIVATE ORGANIZATIONS IN OUR QUEST TO PREVENT AND TREAT AD/ADRD. EXPOSURE TO RHI IS ASSOCIATED WITH CTE AND A WIDE RANGE OF OTHER AD/ADRD PATHOLOGIES. AS RECOGNIZED LEADERS IN THIS SPACE, WE ARE UNIQUELY POSITIONED TO SUPPORT RESEARCH ON GENETIC AND OTHER RISKS FACTORS AND STUDY HOW RHI AFFECTS THE CLINICAL COURSE, BIOMARKER PROFILE, AND CLINICAL-PATHOLOGICAL FEATURES OF AD/ADRD INCLUDING CTE.

ENTITLED CITIES

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

ENTITLED CITIES

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

CONNECT HISTORIC BOSTON

CARES ACT: EMERGENCY FINANCIAL AID GRANTS TO STUDENTS UNDER THE CARES ACT.

HEALTH CENTER CLUSTER

RECOVERY ACT

MONOCLONAL ANTIBODY-BASED MULTIPURPOSE MICROBICIDES

ENDOTHELIAL REDOX STATE & PHENOTYPE IN HEALTH & DISEASE

SSI/SSDI DEMONSTRATIONS

NATIONAL RESEARCH MENTORING NETWORK FOR A DIVERSE BIOMEDICAL WORKFORCE

NEIGHBORHOOD STABILIZATION PROGRAM (RECOVERY ACT FUNDED)

OUR HELIOSPHERIC SHIELD

NEONATAL BIOMARKERS IN EXTREMELY PRETERM BABIES PREDICT CHILDHOOD BRAIN DISORDERS

FINAL CLINICAL STUDIES FOR SUBMISSION OF A PRE-MARKET APPROVAL APPLICATION TO THE FDA FOR A BIONIC PANCREAS THAT AUTOMATES TYPE 1 DIABETES MANAGEMENT

PERFORM FUNDING SYS

LOCAL NEURONAL DRIVE AND NEUROMODULATORY CONTROL OF ACTIVITY IN THE PIAL NEUROVASCULAR CIRCUIT - PROJECT SUMMARY/ABSTRACT – OVERALL WE SEEK TO UNDERSTAND THE NATURE OF THE PIAL NEUROVASCULAR CIRCUIT, WHOSE DYNAMICS IS CHARACTERIZED BY ULTRALOW FREQUENCY OSCILLATIONS NEAR 0.1 HZ THAT PARCELLATE INTO SEPARATE COHERENT REGIONS ACROSS CORTEX. WE WILL USE THIS KNOWLEDGE TO FORM A MATHEMATICAL RELATION BETWEEN THE HEMODYNAMIC PATTERNS OBSERVED IN OPTICAL AND FUNCTIONAL MAGNETIC RESONANCE IMAGING EXPERIMENTS AND THE UNDERLYING BRAIN STATE. OUR PROPOSED STUDIES PROPOSE TO LEVERAGE OUR EXPERIMENTAL EXPERTISE IN IN VIVO OPTICAL MICROSCOPY IN MOUSE AND FMRI IN MOUSE AND HUMAN. THESE PRIMARY MODALITIES FOR DATA ACQUISITION ARE COMBINED WITH BEHAVIORAL TRAINING, ELECTROPHYSIOLOGY, AND DATA ANALYSIS. OUR EXPERIMENTAL EFFORT IS PARALLEL BY TWO THEORETICAL EFFORTS. ONE MIXED ANALYTICAL/COMPUTATIONAL EFFORT IS ON COUPLED OSCILLATOR DYNAMICS TO FORMULATE MODELS, AT VARYING LEVELS OF COMPLEXITY, OF THE PIAL NEUROVASCULAR CIRCUIT. A SECOND SOLELY COMPUTATIONAL EFFORT CONCERNS THE MODULATION OF THE TRANSPORT OF OXYGEN, BY REGIONAL OSCILLATIONS OF THE PIAL NEUROVASCULAR CIRCUIT. THE PIAL NEUROVASCULAR CIRCUIT IS COMPOSED OF A TWO-DIMENSIONAL NETWORK OF PIAL ARTERIOLES THAT UNDERGO RHYTHMIC OSCILLATIONS IN THE ~ 0.1 HZ VASOMOTOR BAND. EACH ELEMENT IN THIS CIRCUIT - A SEGMENT OF ARTERIOLE WHOSE DIAMETER IS MODULATED BY THE CONSTRICTION/DILATION OF SMOOTH MUSCLE, CONTAINS AN INTRINSIC RHYTHM GENERATOR, MUCH LIKE INTRINSIC BURSTING NEURONS IN CENTRAL PATTERN GENERATORS. THE PIAL ARTERIOLES INTEGRATE NEURONAL ACTIVITY FROM NEIGHBORING ARTERIOLES, UNDERLYING NEURONS, SUBCORTICAL NEURONS, AND NEUROMODULATORY CENTERS TO PRODUCE DYNAMIC PATTERNS OF COHERENT OSCILLATIONS IN ARTERIOLAR DIAMETER ACROSS THE CORTICAL MANTLE. THESE PATTERNS CONTAIN REGIONS THAT OSCILLATE AT SLIGHTLY DIFFERENT FREQUENCIES, I.E., THEY PARCELLATE INTO SEPARATE REGIONS. THE FASCINATING ISSUE IS THAT THE PARCELLATION ONLY PARTIALLY REFLECTS INPUT FROM THE DIRECTLY UNDERLYING NEURONAL INPUT. WE SEEK TO UNDERSTAND, MODEL, AND EXPLOIT THIS PARCELLATION. THE PIS HAVE COLLABORATED ON ISSUES IN NEUROSCIENCE AND NEUROVASCULAR SCIENCE FOR MANY YEARS. THIS PROPOSAL IS A RESULT OF THEIR DISCOVERIES AND CONVERGING INTEREST IN A STRUCTURED COLLABORATIVE EFFORT. PROJECT 1 WILL FORMULATE AN UNDERSTANDING OF FUNDAMENTAL PHYSIOLOGY OF THE PIAL NEUROVASCULAR CIRCUIT. THIS INCLUDES DETERMINING IF BRAIN ARTERIOLES TRULY ACT AS INTERACTING NON-LINEAR OSCILLATORS, I.E., THAT THEY ENTRAIN AND PHASE-LOCK RATHER THAN PASSIVELY FILTER. PROJECTS 1, 2, AND 4 WILL EXPLORE EXPERIMENTALLY AND THEORETICALLY HOW FOUR COMPETITIVE INTERACTIONS, VIZ, INPUT FROM NEIGHBORING ARTERIOLES, (II) INPUT FROM UNDERLYING NEURONS, (III) INPUT FROM SUBCORTICAL AREAS INVOLVED IN HOMEOSTASIS; AND (IV) INPUT FROM BRAIN NEUROMODULATORY CENTERS, LEAD TO THE OBSERVED PATTERNS OF PIAL NEUROVASCULAR ACTIVITY. PROJECTS 2 AND 4 WILL EXPLORE AND MODEL THE REGULATION OF OXYGEN IN SUBSURFACE VESSELS, WHILE PROJECT 3 WILL EXPAND THE RESOLUTION OF MR IMAGING IN HUMANS TO OBSERVE SINGLE VESSELS CBV CHANGES AND THUS MEASURE PIAL NEUROVASCULAR DYNAMICS WITH UNPARALLELED RESOLUTION. A PARTICULAR INTEREST IS TO TRANSFORM SPATIOTEMPORAL PATTERNS OF VASOMOTION INTO PREDICTIONS OF INTERNAL BRAIN STATE.

PRECURSORS OF STROKE INCIDENCE AND PROGNOSIS

BOSTON COLLEGE & AFFILIATED INSTITUTIONS: RETIREMENT RESEARCH CONSORTIUMPROGRAM ANNOUNCEMENT NO. SSA-OAG-09-1

STAFFING FOR ADEQUATE FIRE AND EMERGENCY RESPONSE (SAFER)

MINIMALLY VERBAL ASD: FROM BASIC MECHANISMS TO INNOVATIVE INTERVENTIONS

A FOLLOW-UP STUDY FOR CAUSES OF CANCER IN BLACK WOMEN

PREDICTING AND OPTIMIZING LANGUAGE OUTCOMES IN MINIMALLY VERBAL CHILDREN WITH AUTISM SPECTRUM DISORDER

PERFORM FUNDING SYS

ARRA - FACILITY INVESTMENT PROGRAM

DETERMINANTS OF CELL FATE AND DIFFERENTIATION IN THE DEVELOPING LUNG

BRAIN IMMUNE INTERACTIONS AS THE BASIS OF GULF WAR ILLNESS: GULF WAR ILLNESS CONSORTIUM (GWIC)

COPS HIRING RECOVERY PROGRAM

BOSTON PUBLIC HEALTH INFRASTRUCTURE AND WORKFORCE IMPROVEMENTS PROJECT - THE PURPOSE OF THE PROPOSED PROJECT IS TO MAKE INVESTMENTS IN THE BOSTON PUBLIC HEALTH COMMISSION’S WORKFORCE AND FOUNDATIONAL CAPABILITIES, WHICH WILL HELP IT ACHIEVE ITS MISSION OF PROTECTING, PRESERVING AND PROMOTING THE HEALTH AND WELL-BEING OF ALL BOSTON RESIDENTS, PARTICULARLY THOSE WHO ARE MOST VULNERABLE. THE PROPOSED INVESTMENTS ARE IN LINE WITH BPHC’S STRATEGIC PLAN AND OUR COMMITMENT TO BE A MODEL LEADER IN ADDRESSING RACIAL JUSTICE AND HEALTH EQUITY. THE EXPECTED OUTCOMES OF THIS INVESTMENT ARE TO: BUILD BPHC INTO A HEALTH DEPARTMENT THAT BEST REPRESENTS THE NEIGHBORHOODS IT SERVES; PROMOTE AND SUSTAIN A WORK ENVIRONMENT WHERE STAFF THRIVE AND ACHIEVE PERSONAL AND PROFESSIONAL GROWTH; INCREASE ACCESS TO PROFESSIONAL DEVELOPMENT OPPORTUNITIES FOR BPHC STAFF; AND GROW BPHC’S CAPACITY TO USE TECHNOLOGY, DATA AND EFFECTIVE COMMUNICATIONS STRATEGIES TO DRIVE ITS PROGRAMMING AND PARTNERSHIPS. WITHIN THE WORKFORCE COMPONENT, SPECIFIC OUTCOMES INCLUDE INCREASED HIRING OF DIVERSE STAFF AND INCREASED SIZE AND CAPABILITIES OF THE PUBLIC HEALTH WORKFORCE WITH IMPROVED WAGES AND PROTECTIONS. WITHIN FOUNDATIONAL CAPABILITIES, THE KEY OUTCOMES INCLUDE IMPROVED ORGANIZATIONAL SYSTEMS AND PROCESSES AND EVIDENCE OF STRONGER PUBLIC HEALTH FOUNDATIONAL CAPABILITIES.

INFLATION REDUCTION ACT HEALTHY PLACES BOSTON GROWING AN ACCESSIBLE INCLUSIVE AND RESILIENT URBAN FOREST

MULTICENTER OSTEOARTHRITIS STUDY (MOST) RENEWAL

MRI COGNITIVE GENETIC & BIOMARKER PRECURSORS OF AD & DEMENTIA IN YOUNG ADULTS

THERAPEUTIC TARGET DISCOVERY IN ADSP DATA VIA COMPREHENSIVE WHOLE-GENOME ANALYSIS INCORPORATING ETHNIC DIVERSITY AND SYSTEMS APPROACHES

EARLY HEAD START - CHILD CARE PARTNERSHIP

CAPITAL FUND RECOVERY ACT (COMPETITIVE)

ANTIBODY-BASED CONTRACEPTIVE MPTS: PRECLINICAL AND CLINICAL RESEARCH

PUBLIC AND INDIAN HOUSING

IMPROVING CAUSAL INFERENCE IN ALZHEIMER'S DISEASE PREVENTION RESEARCH ON MODIFIABLE RISK FACTORS: THE TRIANGULATION OF INNOVATIVE METHODS TO ENDAD (TIME-AD) PROJECT - OVERALL COMPONENT PROJECT SUMMARY RESEARCH ON ALZHEIMER’S DISEASE AND ALZHEIMER’S DISEASE RELATED DEMENTIAS (AD/ADRD) HAS IDENTIFIED SEVERAL PROMISING RISK FACTORS WHICH COULD GUIDE STRATEGIES TO PREVENT UP TO 40% OF AD/ADRD. NEARLY ALL PRIOR EVIDENCE RELIES ON OBSERVATIONAL DATA, WHICH IS PRONE TO BIASES FROM UNMEASURED CONFOUNDING, REVERSE CAUSATION, SELECTIVE SURVIVAL, AND MEASUREMENT ERROR. THE TRIANGULATION OF INNOVATIVE METHODS TO END AD (TIME-AD) PROGRAM ADDRESSES THESE CHALLENGES BY USING AN EVIDENCE TRIANGULATION FRAMEWORK FOR STRENGTHENING CAUSAL INFERENCE IN OBSERVATIONAL DATA. THIS FRAMEWORK SYSTEMATICALLY EVALUATES BIASES, PLANNING COMPLEMENTARY ANALYSIS APPROACHES WITH DIFFERENT DATA SOURCES AND STUDY DESIGNS TO RULE OUT ALTERNATIVE INTERPRETATIONS FOR THE ASSOCIATION OF EACH RISK FACTOR AND AD/ADRD: A) DOUBLY ROBUST OBSERVATIONAL METHODS COMBINING PROPENSITY SCORE MODELS WITH OUTCOME MODELS; B) INSTRUMENTAL VARIABLES (IV) METHODS USING GENETIC AND POLICY VARIATIONS THAT INTRODUCE RANDOM VARIATION IN EXPOSURE; AND C) QUANTITATIVE BIAS ANALYSIS TO CHARACTERIZE UNCERTAINTY. PROJECT 1 WILL ADDRESS THE EFFECTS OF ALCOHOL USE ACROSS THE LIFECOURSE ON COGNITIVE AGING AND AD/ADRD RISK. PROJECT 2 WILL EVALUATE THE EFFECTS OF DEPRESSION AND DEPRESSION TREATMENT ON AD/ADRD RISK AND POSSIBLE DIRECT AND MODIFYING ROLES OF CHRONIC PAIN. PROJECT 3 WILL ASSESS WHETHER AD/ADRD RISK MAY BE REDUCED BY PREVENTION OR TREATMENT OF VISION OR HEARING IMPAIRMENTS. PROJECT 4 WILL ASSESS THE IMPACTS OF SOCIAL ISOLATION, FOCUSING ON COMPONENTS OF SOCIAL ISOLATION THAT ARE MODIFIABLE WITH EXISTING INTERVENTIONS. EACH OF THESE EXPOSURES IS KNOWN TO BE ASSOCIATED WITH AD/ADRD OUTCOMES IN HIGHLY EDUCATED, PREDOMINANTLY WHITE POPULATIONS; THE CURRENT PROPOSALS WILL EXTEND OUR KNOWLEDGE BY FOCUSING ON CAUSATION, INCLUDING LARGE, DIVERSE SAMPLES, AND RIGOROUSLY EVALUATING HETEROGENEITY ACROSS POPULATIONS. IN ADDITION TO AN ADMINISTRATIVE CORE, PROJECTS WILL BE SUPPORTED BY A COGNITIVE OUTCOMES, EXPOSURE VARIABLES, AND COVARIATES DATA CORE, WHICH WILL HELP THE INTENSIVE DATA MANAGEMENT INVOLVED IN CONSTRUCTING ANALYTIC DATA SETS AND FOSTER HARMONIZED MEASURES AND COORDINATED ANALYSES, DRAWING ON MULTIPLE DATA SOURCES TO SUPPORT EVIDENCE TRIANGULATION. A GENETIC AND POLICY DATA CORE WILL BRING SPECIALIZED EXPERTISE ON GENETICS, POLICIES, AND IV ANALYSIS, PROVIDING CODE TO CONSTRUCT, VALIDATE, AND IMPLEMENT IV ANALYSES. AN ANALYTICS CORE WILL DEVELOP AND SHARE REUSABLE ANALYTIC CODE AND SUPPORT IMPLEMENTATION OF THE MOST UP-TO- DATE METHODOLOGY; AND AN EQUITY AND DISSEMINATION CORE WILL ENSURE AN EQUITY FOCUS IS MAINTAINED THROUGHOUT TIME-AD, MAXIMIZING THE RELEVANCE OF OUR FINDINGS TO IMPROVE OUTCOMES AMONG POPULATIONS TYPICALLY UNDERREPRESENTED IN AD/ADRD RESEARCH. THE EQUITY AND DISSEMINATION CORE WILL ENSURE THAT RESEARCH IMPLEMENTATION IS GUIDED BY POTENTIAL APPLICATIONS OF THE EVIDENCE AND THAT THE FINDINGS OF EACH STUDY ARE BROADLY DISSEMINATED TO STAKEHOLDERS WHO CAN ACT ON THE EVIDENCE. THE SYNERGIES CREATED BY SHARED CORES WITH EXPERTISE IN DATA, ANALYSIS, AND EQUITY AND DISSEMINATION ENSURE THAT TIME-AD WILL HAVE HIGH IMPACT.

CENTER FOR RETIREMENT RESEARCH AT BOSTON COLLEGE AND AFFILIATED INSTITUTIONS: RETIREMENT AND DISABILITY RESEARCH CONSORTIUM

PURPOSE: THE PUBLIC HOUSING OPERATING FUND (PH OPFUND) PROVIDES OPERATING SUBSIDIES TO HOUSING AUTHORITIES (HAS) TO ASSIST IN FUNDING THE OPERATING AND MAINTENANCE EXPENSES OF THEIR DWELLINGS, IN ACCORDANCE WITH SECTION 9 OF THE U.S. HOUSING ACT OF 1937, AS AMENDED. THE SUBSIDIES ARE REQUIRED TO HELP MAINTAIN SERVICES AND PROVIDE MINIMUM OPERATING RESERVES. THE PH OPFUND IS A $5 BILLION DOLLAR PROGRAM PROVIDING FUNDING TO APPROXIMATELY 6,000 HAS SERVING 1,590,321 PUBLIC HOUSING RESIDENTS IN 902,436 HOUSEHOLDS (44% ARE ELDERLY AND 35% OF RESIDENTS HAVE CHILDREN). INFORMATION ON THE CURRENT OPERATING FUND GRANT PROCESSING CAN BE FOUND AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/PUBLIC_INDIAN_HOUSING/PROGRAMS/PH/AM/FUNDING.; ACTIVITIES TO BE PERFORMED: OPERATING FUNDS ARE USED TO FUND DAY-TO-DAY OPERATIONAL EXPENSES ASSOCIATED WITH PUBLIC HOUSING AS WELL AS THE ADMINISTRATIVE AND PROGRAM IMPLEMENTATION EXPENSES THAT PUBLIC HOUSING AGENCIES (PHAS) ARE REQUIRED TO UNDERTAKE UNDER THE 1937 HOUSING ACT AND PROGRAM REGULATIONS. SUCH ACTIVITIES INCLUDE MANAGEMENT AND OPERATIONS, ROUTINE AND PREVENTATIVE MAINTENANCE, ANTI-CRIME, ANTI-DRUG AND SECURITY ACTIVITIES, OPERATING COSTS FOR PRIVATELY OWNED PUBLIC HOUSING UNITS WITHIN MIXED-FINANCE PROJECTS, ENERGY COSTS, RESIDENT SUPPORTIVE SERVICES, INSURANCE, DEBT SERVICE AND COSTS ASSOCIATED WITH ADMINISTRATION AND PROGRAM IMPLEMENTATION. TURNKEY III PROJECTS ARE FUNDED FOR UNITS UNDER THE FINAL LEASE PURCHASE AGREEMENT FOR CLOSING OUT THE PROGRAM. TO SUPPORT THESE ACTIVITIES, THERE IS CONTINUED MODERNIZATION OF THE INFORMATION TECHNOLOGY PLATFORMS. PHAS HAVE ACCESS TO WEB-BASED PLATFORMS THAT UTILIZE REAL-TIME DATA TO PROVIDE INSIGHT INTO THEIR PORTFOLIOS. PHAS CAN OBTAIN METRICS ON THEIR FUNDING LEVELS, OCCUPANCY RATES, AND THE NUMBER OF FAMILIES SERVED THROUGH RENTAL ASSISTANCE.; EXPECTED OUTCOMES: AS A RESULT OF THE ACTIVITIES PERFORMED, THIS PROGRAM IS EXPECTED TO ASSIST IN FUNDING THE OPERATING AND MAINTENANCE EXPENSES. THIS MAY INCLUDE INCREASED OCCUPANCY IN PUBLIC HOUSING, DECREASED ENERGY COSTS THROUGH REGULAR MAINTENANCE AND ENERGY PERFORMANCE CONTRACTING AND LEVERAGE FEDERAL RESOURCES. IN ADDITION TO ADDRESSING THE DEPARTMENT’S STRATEGIC GOALS OF: • ADDRESSING THE NEED FOR QUALITY AFFORDABLE RENTAL HOMES BY MAINTAINING OR IMPROVING UPON THE 96% OCCUPANCY RATE OF HABITABLE UNITS; • PROMOTING HOUSING AS A PLATFORM TO IMPROVE QUALITY OF LIFE THROUGH SUPPORTIVE SERVICES, CRIME PREVENTION EFFORTS AND RESIDENT ENGAGEMENT ACTIVITIES; AND • HELPING TO BUILD INCLUSIVE COMMUNITIES FREE FROM DISCRIMINATION BY FACILITATING THE IMPLEMENTATION OF AFFIRMATIVELY FURTHERING FAIR HOUSING MEASURES.; INTENDED BENEFICIARIES: THE OPERATING FUND PROVIDES FOR THE OPERATION AND MAINTENANCE OF LOW-INCOME HOUSING PROJECTS TO PHAS/PROJECTS. IT WAS CREATED TO ASSIST HOUSING AUTHORITIES IN PROVIDING DECENT AND SAFE RENTAL HOUSING FOR ELIGIBLE LOW-INCOME FAMILIES OR INDIVIDUALS, THE ELDERLY, AND PERSONS WITH DISABILITIES. A HA DETERMINES ELIGIBILITY BASED ON 1) ANNUAL GROSS INCOME; 2) A PERSON ON WHO IS ELDERLY, A PERSON WITH A DISABILITY, OR AS A FAMILY; AND 3) U.S. CITIZENSHIP OR ELIGIBLE IMMIGRATION STATUS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

COMPLEX CHEMOTYPES: DISCOVERY, METHODOLOGY, AND LIBRARY EXPANSION

MASS SPECTROMETRY RESOURCE FOR BIOLOGY AND MEDICINE

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

PURPOSE: THE PUBLIC HOUSING OPERATING FUND (PH OPFUND) PROVIDES OPERATING SUBSIDIES TO HOUSING AUTHORITIES (HAS) TO ASSIST IN FUNDING THE OPERATING AND MAINTENANCE EXPENSES OF THEIR DWELLINGS, IN ACCORDANCE WITH SECTION 9 OF THE U.S. HOUSING ACT OF 1937, AS AMENDED. THE SUBSIDIES ARE REQUIRED TO HELP MAINTAIN SERVICES AND PROVIDE MINIMUM OPERATING RESERVES. THE PH OPFUND IS A $5 BILLION DOLLAR PROGRAM PROVIDING FUNDING TO APPROXIMATELY 6,000 HAS SERVING 1,590,321 PUBLIC HOUSING RESIDENTS IN 902,436 HOUSEHOLDS (44% ARE ELDERLY AND 35% OF RESIDENTS HAVE CHILDREN). INFORMATION ON THE CURRENT OPERATING FUND GRANT PROCESSING CAN BE FOUND AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/PUBLIC_INDIAN_HOUSING/PROGRAMS/PH/AM/FUNDING.; ACTIVITIES TO BE PERFORMED: OPERATING FUNDS ARE USED TO FUND DAY-TO-DAY OPERATIONAL EXPENSES ASSOCIATED WITH PUBLIC HOUSING AS WELL AS THE ADMINISTRATIVE AND PROGRAM IMPLEMENTATION EXPENSES THAT PUBLIC HOUSING AGENCIES (PHAS) ARE REQUIRED TO UNDERTAKE UNDER THE 1937 HOUSING ACT AND PROGRAM REGULATIONS. SUCH ACTIVITIES INCLUDE MANAGEMENT AND OPERATIONS, ROUTINE AND PREVENTATIVE MAINTENANCE, ANTI-CRIME, ANTI-DRUG AND SECURITY ACTIVITIES, OPERATING COSTS FOR PRIVATELY OWNED PUBLIC HOUSING UNITS WITHIN MIXED-FINANCE PROJECTS, ENERGY COSTS, RESIDENT SUPPORTIVE SERVICES, INSURANCE, DEBT SERVICE AND COSTS ASSOCIATED WITH ADMINISTRATION AND PROGRAM IMPLEMENTATION. TURNKEY III PROJECTS ARE FUNDED FOR UNITS UNDER THE FINAL LEASE PURCHASE AGREEMENT FOR CLOSING OUT THE PROGRAM. TO SUPPORT THESE ACTIVITIES, THERE IS CONTINUED MODERNIZATION OF THE INFORMATION TECHNOLOGY PLATFORMS. PHAS HAVE ACCESS TO WEB-BASED PLATFORMS THAT UTILIZE REAL-TIME DATA TO PROVIDE INSIGHT INTO THEIR PORTFOLIOS. PHAS CAN OBTAIN METRICS ON THEIR FUNDING LEVELS, OCCUPANCY RATES, AND THE NUMBER OF FAMILIES SERVED THROUGH RENTAL ASSISTANCE.; EXPECTED OUTCOMES: AS A RESULT OF THE ACTIVITIES PERFORMED, THIS PROGRAM IS EXPECTED TO ASSIST IN FUNDING THE OPERATING AND MAINTENANCE EXPENSES. THIS MAY INCLUDE INCREASED OCCUPANCY IN PUBLIC HOUSING, DECREASED ENERGY COSTS THROUGH REGULAR MAINTENANCE AND ENERGY PERFORMANCE CONTRACTING AND LEVERAGE FEDERAL RESOURCES. IN ADDITION TO ADDRESSING THE DEPARTMENT’S STRATEGIC GOALS OF: • ADDRESSING THE NEED FOR QUALITY AFFORDABLE RENTAL HOMES BY MAINTAINING OR IMPROVING UPON THE 96% OCCUPANCY RATE OF HABITABLE UNITS; • PROMOTING HOUSING AS A PLATFORM TO IMPROVE QUALITY OF LIFE THROUGH SUPPORTIVE SERVICES, CRIME PREVENTION EFFORTS AND RESIDENT ENGAGEMENT ACTIVITIES; AND • HELPING TO BUILD INCLUSIVE COMMUNITIES FREE FROM DISCRIMINATION BY FACILITATING THE IMPLEMENTATION OF AFFIRMATIVELY FURTHERING FAIR HOUSING MEASURES.; INTENDED BENEFICIARIES: THE OPERATING FUND PROVIDES FOR THE OPERATION AND MAINTENANCE OF LOW-INCOME HOUSING PROJECTS TO PHAS/PROJECTS. IT WAS CREATED TO ASSIST HOUSING AUTHORITIES IN PROVIDING DECENT AND SAFE RENTAL HOUSING FOR ELIGIBLE LOW-INCOME FAMILIES OR INDIVIDUALS, THE ELDERLY, AND PERSONS WITH DISABILITIES. A HA DETERMINES ELIGIBILITY BASED ON 1) ANNUAL GROSS INCOME; 2) A PERSON ON WHO IS ELDERLY, A PERSON WITH A DISABILITY, OR AS A FAMILY; AND 3) U.S. CITIZENSHIP OR ELIGIBLE IMMIGRATION STATUS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

PERFORM FUNDING SYS

PREDICTING THE EMERGENCE OF ANTIBIOTIC RESISTANCE THROUGH MULTI-OMICS APPROACHES AND IMMUNE SYSTEM-SURVEILLAN

TRAUMATIC BRAIN INJURY AND REPETITIVE HEAD IMPACTS: CONTRIBUTIONS TO AD/ADRD AND CTE NEUROPATHOLOGY AND RESULTING CLINICAL SYNDROMES

PHOTONICS

COORDINATING CENTER FOR TRANSITION AND POSTSECONDARY PROGRAMS FOR STUDENTS WITH INTELLECTUAL DISABILITIES

EXCEPTIONAL SURVIVAL AND LONGEVITY IN NEW ENGLAND

TRANSITION PROGRAMS FOR STUDENTS WITH INTELLECTUAL DISABILITIES COORDINATING CENTER (COORDINATING CENTERS)

CONTINUUM OF CARE PROGRAM

HEALTH CARE DELIVERY SYSTEM INNOVATIONS FOR CHILDREN WITH MEDICAL COMPLEXITY

PURPOSE: THIS PROGRAM AIMS TO TRAIN INDIVIDUALS FOR GOOD, COASTAL CLIMATE RESILIENT (CCR) JOBS, ALIGNING WITH BOSTON?S CLIMATE READY BOSTON CCR PLAN (COB, 2016) AND MASSACHUSETTS? RESILIENTMASS PLAN (2023?2028). ACTIVITIES TO BE PERFORMED INCLUDE TRAINING OVER 1,000 TOTAL INDIVIDUALS IN: NATURE-BASED SOLUTIONS, WATER UTILITIES, CONSTRUCTION, EMERGENCY PREPAREDNESS AND RESPONSE, MUNICIPAL INFRASTRUCTURE SERVICES, AND COMMUNITY ENGAGEMENT: OUTREACH & RECRUITMENT. EXPECTED OUTCOMES INCLUDE PLACING AT LEAST 777 INDIVIDUALS INTO COMMITTED CCR JOBS. INTENDED BENEFICIARIES INVOLVE INDIVIDUALS FROM COMMUNITIES HISTORICALLY UNDERREPRESENTED IN THE SECTOR, AND THE EMPLOYERS COMMITTED TO HIRING THOSE TRAINED BY THE PROGRAM.

HEAD START

NIAMS MULTIDISCIPLINARY CLINICAL RESEARCH CENTER

PURPOSE: THE PUBLIC HOUSING OPERATING FUND (PH OPFUND) PROVIDES OPERATING SUBSIDIES TO HOUSING AUTHORITIES (HAS) TO ASSIST IN FUNDING THE OPERATING AND MAINTENANCE EXPENSES OF THEIR DWELLINGS, IN ACCORDANCE WITH SECTION 9 OF THE U.S. HOUSING ACT OF 1937, AS AMENDED. THE SUBSIDIES ARE REQUIRED TO HELP MAINTAIN SERVICES AND PROVIDE MINIMUM OPERATING RESERVES. THE PH OPFUND IS A $5 BILLION DOLLAR PROGRAM PROVIDING FUNDING TO APPROXIMATELY 6,000 HAS SERVING 1,590,321 PUBLIC HOUSING RESIDENTS IN 902,436 HOUSEHOLDS (44% ARE ELDERLY AND 35% OF RESIDENTS HAVE CHILDREN). INFORMATION ON THE CURRENT OPERATING FUND GRANT PROCESSING CAN BE FOUND AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/PUBLIC_INDIAN_HOUSING/PROGRAMS/PH/AM/FUNDING.; ACTIVITIES TO BE PERFORMED: OPERATING FUNDS ARE USED TO FUND DAY-TO-DAY OPERATIONAL EXPENSES ASSOCIATED WITH PUBLIC HOUSING AS WELL AS THE ADMINISTRATIVE AND PROGRAM IMPLEMENTATION EXPENSES THAT PUBLIC HOUSING AGENCIES (PHAS) ARE REQUIRED TO UNDERTAKE UNDER THE 1937 HOUSING ACT AND PROGRAM REGULATIONS. SUCH ACTIVITIES INCLUDE MANAGEMENT AND OPERATIONS, ROUTINE AND PREVENTATIVE MAINTENANCE, ANTI-CRIME, ANTI-DRUG AND SECURITY ACTIVITIES, OPERATING COSTS FOR PRIVATELY OWNED PUBLIC HOUSING UNITS WITHIN MIXED-FINANCE PROJECTS, ENERGY COSTS, RESIDENT SUPPORTIVE SERVICES, INSURANCE, DEBT SERVICE AND COSTS ASSOCIATED WITH ADMINISTRATION AND PROGRAM IMPLEMENTATION. TURNKEY III PROJECTS ARE FUNDED FOR UNITS UNDER THE FINAL LEASE PURCHASE AGREEMENT FOR CLOSING OUT THE PROGRAM. TO SUPPORT THESE ACTIVITIES, THERE IS CONTINUED MODERNIZATION OF THE INFORMATION TECHNOLOGY PLATFORMS. PHAS HAVE ACCESS TO WEB-BASED PLATFORMS THAT UTILIZE REAL-TIME DATA TO PROVIDE INSIGHT INTO THEIR PORTFOLIOS. PHAS CAN OBTAIN METRICS ON THEIR FUNDING LEVELS, OCCUPANCY RATES, AND THE NUMBER OF FAMILIES SERVED THROUGH RENTAL ASSISTANCE.; EXPECTED OUTCOMES: AS A RESULT OF THE ACTIVITIES PERFORMED, THIS PROGRAM IS EXPECTED TO ASSIST IN FUNDING THE OPERATING AND MAINTENANCE EXPENSES. THIS MAY INCLUDE INCREASED OCCUPANCY IN PUBLIC HOUSING, DECREASED ENERGY COSTS THROUGH REGULAR MAINTENANCE AND ENERGY PERFORMANCE CONTRACTING AND LEVERAGE FEDERAL RESOURCES. IN ADDITION TO ADDRESSING THE DEPARTMENT’S STRATEGIC GOALS OF: • ADDRESSING THE NEED FOR QUALITY AFFORDABLE RENTAL HOMES BY MAINTAINING OR IMPROVING UPON THE 96% OCCUPANCY RATE OF HABITABLE UNITS; • PROMOTING HOUSING AS A PLATFORM TO IMPROVE QUALITY OF LIFE THROUGH SUPPORTIVE SERVICES, CRIME PREVENTION EFFORTS AND RESIDENT ENGAGEMENT ACTIVITIES; AND • HELPING TO BUILD INCLUSIVE COMMUNITIES FREE FROM DISCRIMINATION BY FACILITATING THE IMPLEMENTATION OF AFFIRMATIVELY FURTHERING FAIR HOUSING MEASURES.; INTENDED BENEFICIARIES: THE OPERATING FUND PROVIDES FOR THE OPERATION AND MAINTENANCE OF LOW-INCOME HOUSING PROJECTS TO PHAS/PROJECTS. IT WAS CREATED TO ASSIST HOUSING AUTHORITIES IN PROVIDING DECENT AND SAFE RENTAL HOUSING FOR ELIGIBLE LOW-INCOME FAMILIES OR INDIVIDUALS, THE ELDERLY, AND PERSONS WITH DISABILITIES. A HA DETERMINES ELIGIBILITY BASED ON 1) ANNUAL GROSS INCOME; 2) A PERSON ON WHO IS ELDERLY, A PERSON WITH A DISABILITY, OR AS A FAMILY; AND 3) U.S. CITIZENSHIP OR ELIGIBLE IMMIGRATION STATUS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

PUBLIC AND INDIAN HOUSING

COMPARING AVIATION HEALTH IMPACTS WITH OTHER SOURCE SELECTORS

PERFORM FUNDING SYS

PUBLIC AND INDIAN HOUSING

TACE

LIFETIME STRESSORS AND ALZHEIMER'S DISEASE GENETIC VARIANTS AND BIOMARKERS IN RELATION TO COGNITIVE DECLINE AMONG BLACK WOMEN'SHEALTH STUDY PARTICIPANTS. - ABSTRACT OLDER BLACK AMERICANS HAVE HIGHER RATES OF COGNITIVE IMPAIRMENT AND ALZHEIMER’S DISEASE (AD) THAN THEIR WHITE COUNTERPARTS, A DISPARITY THAT IS GREATER FOR BLACK WOMEN. GIVEN THE LACK OF EFFECTIVE THERAPIES TO SLOW DISEASE PROGRESSION AND SYMPTOMS, EFFECTIVE PREVENTION IS NEEDED. MOST KNOWLEDGE OF RISK FACTORS FOR COGNITIVE DECLINE, THE HALLMARK FEATURE OF AD, COMES FROM STUDIES OF WHITE POPULATIONS AND THE CONTRIBUTION OF RACIALLY/SOCIALLY-PATTERNED RISK FACTORS AMONG BLACK ADULTS REMAINS UNDER-STUDIED. WE PROPOSE TO STUDY 2,500 BLACK WOMEN AGES 55 AND OLDER FROM THE BLACK WOMEN’S HEALTH STUDY (BWHS), A FOLLOW-UP STUDY OF 59,000 BLACK WOMEN FROM ACROSS THE US. OUR GOAL IS TO IDENTIFY SOCIAL FACTORS THAT, TOGETHER WITH BIOMARKERS OF AD, INFLUENCE COGNITIVE DECLINE. THE BWHS PROVIDES A UNIQUE OPPORTUNITY TO ACCOMPLISH THIS GOAL. OVER 27 YEARS, THE BWHS HAS COLLECTED DATA THROUGH BIENNIAL QUESTIONNAIRES FROM PARTICIPANTS ON SOCIOECONOMIC, PSYCHOLOGICAL, AND PHYSICAL STRESSORS OCCURRING AT VARIOUS TIMES OF LIFE (E.G., LOW PARENTAL EDUCATION, CHILDHOOD SEXUAL/PHYSICAL ABUSE, INTERPERSONAL RACISM), AS WELL AS INFORMATION ON MANY POTENTIAL RISK FACTORS FOR AD AND COGNITIVE DECLINE (E.G., DEMOGRAPHICS, BODY SIZE, BEHAVIORAL FACTORS (E.G., EXERCISE, DIET, SMOKING), MEDICAL HISTORY, REPRODUCTIVE HISTORY, MEDICATION USE, HEALTH CARE). THE BWHS HAS COLLECTED AND STORED BLOOD FROM A LARGE SUBSAMPLE OF PARTICIPANTS WHO AGREED TO WIDE SHARING, SUCH AS GWAS RESULTS WITH OTHER INVESTIGATORS AND PUBLIC DATABASES. AFTER ENROLLMENT OF 2,500 SUCH PARTICIPANTS WITH ALREADY-COLLECTED BLOOD SAMPLES FROM THE BWHS, WE PROPOSE TO ADMINISTER A VALIDATED TELEPHONE COGNITIVE BATTERY ANNUALLY TO MEASURE COGNITION. WE WILL ALSO MEASURE A PANEL OF AT(N) PLASMA BIOMARKERS AND CONDUCT GWAS IN ORDER TO EXAMINE THE ASSOCIATIONS OF PLASMA BIOMARKERS AND GENETIC VARIANTS WITH COGNITIVE DECLINE. BASED ON THE COLLECTED DATA AND THE RESULTS FROM BIOMARKER ASSESSMENTS, WE WILL ASSESS THE JOINT EFFECTS OF THE STRESSORS AND BIOMARKERS ON COGNITIVE DECLINE. A FEASIBILITY STUDY DEMONSTRATED THE WILLINGNESS OF BWHS PARTICIPANTS TO COMPLETE THE COGNITIVE TEST BATTERY OVER THE TELEPHONE AND INDICATED THAT ENOUGH BWHS PARTICIPANTS WILL PARTICIPATE TO REACH A STUDY SIZE OF ~2,500 PARTICIPANTS. THE INVESTIGATORS HAVE THE EXPERIENCE AND EXPERTISE TO ENROLL PARTICIPANTS; MEASURE COGNITION WITH A VALIDATED TELEPHONE COGNITIVE BATTERY; MEASURE AT(N) BIOMARKERS IN STORED PLASMA AND CONDUCT GWAS; AND WITH THESE DATA, TO ASSESS THEIR SEPARATE AND JOINT EFFECTS ON COGNITIVE DECLINE. THE PROPOSED STUDY PROVIDES AN UNPARALLELED OPPORTUNITY TO LEVERAGE A LARGE NATIONAL SAMPLE OF OLDER BLACK WOMEN ON WHICH COMPREHENSIVE DATA ON MANY FACTORS THAT AFFECT COGNITION HAVE BEEN COLLECTED TO IDENTIFY LIFE-COURSE RISK FACTORS FOR COGNITIVE DECLINE. THE FINDINGS WILL HAVE IMPORTANT TRANSLATIONAL IMPLICATIONS FOR EFFORTS TO PREVENT COGNITIVE DECLINE IN ALL POPULATIONS, BUT ESPECIALLY IN BLACK WOMEN WHO ARE DISPROPORTIONATELY BURDENED.

NEW FIRE STATION CONSTRUCTION PROJECT

MODELING AFFINITY MATURATION AT MOLECULAR RESOLUTION

PERFORM FUNDING SYS

CALENDAR 2008 FAMILY PLANNING PROJECT

COMMUNITY PARTNERSHIPS FOR TEACHER PIPELINE

CONTINUUM OF CARE PROGRAM

CAF?: A RESEARCH COORDINATING CENTER TO CONVENE, ACCELERATE, FOSTER, AND EXPAND THE CLIMATE CHANGE AND HEALTH COMMUNITY OF PRACTICE - PROJECT SUMMARY / ABSTRACT RESEARCH IN CLIMATE AND HEALTH IS CURRENTLY HAMPERED BECAUSE: (1) THE COMMUNITY OF PRACTICE (COP) IN THIS SPACE IS FRACTURED, FREQUENTLY SILOED WITHIN DISCIPLINES, AND CONCENTRATED IN A FEW WELL-RESOURCED INSTITUTIONS AND COUNTRIES; (2) CUTTING-EDGE DATA ASSETS EXIST, BUT ARE OFTEN HARD TO FIND, INCONSISTENTLY DOCUMENTED, AND CHALLENGING TO MANAGE AND LINK TO OTHER DATA RESOURCES; (3) MANY RESEARCHERS, ESPECIALLY EARLY-STAGE INVESTIGATORS (ESIS), DO NOT HAVE ACCESS TO COMPLIANT, COMPUTATIONALLY EFFICIENT, AND SECURE COMPUTING ENVIRONMENTS; AND (4) WE LACK A CENTRALIZED PLATFORM THAT CAN SUPPORT THE DOMESTIC AND GLOBAL CAPACITY-BUILDING INITIATIVES NEEDED TO EXPAND PATHWAYS FOR CCH RESEARCHERS, INCLUDING PROVIDING EDUCATIONAL RESOURCES, MENTORING, AND FUNDING FOR PILOT AND TIME-SENSITIVE PROJECTS. WE PROPOSE TO CREATE THE BUSPH-HSPH-CAFÉ, A RESEARCH COORDINATING CENTER (RCC) LEVERAGING THE ECOSYSTEM OF STATE-OF-THE-ART RESEARCH, EDUCATION, AND POLICY TRANSLATION IN CLIMATE CHANGE AND HEALTH (CCH) AT THE BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH AND THE HARVARD T.H. CHAN SCHOOL OF PUBLIC HEALTH TO: (1) CONVENE THE COMMUNITY OF PRACTICE (COP) VIA THE ADMINISTRATIVE FUNCTION; (2) ACCELERATE RESEARCH VIA THE DATA MANAGEMENT FUNCTION; (3) FOSTER COLLABORATIONS ACROSS THE COP VIA THE RESOURCE FUNCTION; AND (4) EXPAND THE CCH- COP VIA THE CAPACITY BUILDING FUNCTION. DR. GREGORY WELLENIUS, DR. FRANCESCA DOMINICI, AND DR. AMRUTA NORI-SARMA ARE THE IDEAL MULTIPLE-PI TEAM FOR THE CAFÉ BASED ON: (1) THEIR LARGE AND DIVERSE NETWORK OF COLLABORATORS, INCLUDING TOP EXPERTS IN THE FIELDS OF CLIMATE CHANGE, ADVERSE HEALTH OUTCOMES, ENVIRONMENTAL EPIDEMIOLOGY, DATA SCIENCES, AND STATISTICS, (2) THEIR PRIOR EXPERIENCE LEADING HIGH-IMPACT RESEARCH RELEVANT TO CCH; AND (3) THEIR COMMITMENT TO CAPACITY BUILDING THROUGH MENTORSHIP AND SUPPORT, PARTICULARLY IN SUPPORT OF DIVERSITY AND INCLUSION. BY ENGAGING OUR PARTNERS IN NGOS, GOVERNMENT, INDUSTRY, AND COMMUNITY-BASED GROUPS, AND BY LEVERAGING THE EXPERTISE OF THE PIS, THE CAFÉ WILL ENABLE THE COP TO MORE RAPIDLY AND EFFECTIVELY ADVANCE OUR UNDERSTANDING – AND MINIMIZE THE CONSEQUENCES – OF THE HEALTH CONSEQUENCES OF CONTINUED CLIMATE CHANGE RESEARCH ADVANCES OF THE COP WILL BE TIMELY, POLICY-RELEVANT, AND CATALYTIC, WITH FAR-REACHING APPLICATIONS FOR IMPROVED LOCAL, NATIONAL, AND GLOBAL CLIMATE RESILIENCE.

CENTER FOR INNOVATION IN POINT OF CARE TECHNOLOGIES FOR THE FUTURE OF CANCER CARE

ION CHANNEL MODULATION BY THE PRION PROTEIN: A NOVEL TOXIC MECHANISM

PUBLIC AND INDIAN HOUSING

PUBLIC AND INDIAN HOUSING

OXIDATIVE STRESS, AMPK & DIABETIC CARDIOVASCULAR DISEASE

EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDY

PUBLIC AND INDIAN HOUSING

PREFRONTAL AND MEDIAL-TEMPORAL INTERACTIONS IN MEMORY

TRANSLATING RESEARCH INTO PRACTICE: A REGIONAL COLLABORATIVE TO REDUCE DISPARITIES IN BREAST CANCER CARE

A FOLLOW-UP STUDY FOR CAUSES OF ILLNESS IN BLACK WOMEN

PUBLIC AND INDIAN HOUSING

CONTINUUM OF CARE PROGRAM

DEVELOPING PLURIPOTENT STEM CELLS TO MODEL AND TREAT LUNG DISEASE - SUMMARY: OVERALL PROGRAM THE GOAL OF THIS PROGRAM PROJECT GRANT (PPG) IS ADVANCING THE LATEST DISCOVERIES IN STEM CELL BIOLOGY, HUMAN ORGANOID MODELS, AND GENE EDITING TO UNDERSTAND AND TREAT GENETIC LUNG DISEASES. AFTER A CENTURY OF BASIC SCIENCES ADVANCES, CULMINATING IN RECENT NOBEL PRIZE-WINNING DISCOVERIES, SUCH AS NUCLEAR REPROGRAMMING AND GENE EDITING, BIOMEDICAL RESEARCH NOW FACES AN INFLECTION POINT, POISED FOR CLINICAL TRANSLATION OF BASIC SCIENCE SUCCESSES. WHILE IT IS HARD TO ENVISION A MORE OPTIMISTIC TIME IN HEALTH-RELATED RESEARCH, TREATMENTS FOR MANY DEVASTATING LUNG DISEASES HAVE NOT YET BEEN REALIZED, AND CLINICAL THERAPIES IN MOST CASES STILL LARGELY FOCUS ON TREATING SYMPTOMS OR MAINTAINING LIFE SUPPORT TO ALLOW ENDOGENOUS LUNG TISSUE STEM CELLS ENOUGH TIME TO REPAIR, WITHOUT AVAILABLE THERAPIES ABLE TO INTERRUPT DISEASE-INITIATING MECHANISMS OR AUGMENT THE LUNG’S CAPACITY TO REGENERATE. HERE WE ADDRESS THESE CHALLENGES BY PROPOSING AN INTEGRATED, MULTI-INVESTIGATOR PPG TO TRANSLATE LUNG STEM CELL RESEARCH FROM BASIC DISCOVERY TO FUTURE CLINICAL APPLICATIONS. AN INITIAL FOCUS ON AMELIORATING GENETIC LUNG DISEASES OF THE AIRWAY AND ALVEOLI IS PURSUED, GIVEN THAT THEIR PROXIMAL DISEASE-DRIVING GENE MUTATIONS ARE WELL DESCRIBED. THE USE INDUCED PLURIPOTENT STEM CELLS (IPSCS) CARRYING THESE MUTATIONS OR THEIR GENE-EDITED PROGENY IS A SHARED TECHNOLOGY HARNESSED BY ALL PROJECTS TOGETHER WITH A PROPOSED GENE EDITING CORE, AND COORDINATED BY AN ADMINISTRATIVE CORE. OUR 4 PROJECT LEADERS HAVE WORKED TOGETHER EXTENSIVELY TO DEVELOP PROTOCOLS TO DIFFERENTIATE IPSCS INTO A BROAD DIVERSITY OF LUNG EPITHELIAL LINEAGES, RECENTLY OPTIMIZING METHODS TO PRODUCE THE TWO STEM CELL POPULATIONS THAT MAINTAIN ALL AIRWAY AND ALVEOLAR EPITHELIA, BASAL CELLS AND ALVEOLAR TYPE 2 CELLS (AT2S), RESPECTIVELY. HAVING ESTABLISHED THESE STEM CELL BANKS AND PROTOCOLS, WE TURN OUR FOCUS HERE ON APPLYING THESE RESOURCES TO ADVANCE OUR MECHANISTIC UNDERSTANDING OF HOW GENE MUTATIONS INITIATE AIRWAY AND ALVEOLAR EPITHELIAL DYSFUNCTION RESULTING IN DISEASE, AND WE SEEK TO THERAPEUTICALLY INTERVENE WITH NOVEL PRECISION THERAPEUTICS OR REGENERATIVE CELL THERAPIES. TOWARDS THESE GOALS, WE HERE PROPOSE 4 PROJECTS AND 2 CORES, ALL INTERACTING TO COMPLETE SHARED AIMS, AND SYNERGISTIC CROSS-PROJECT EXPERIMENTS. AIM 1 WILL PROMOTE COLLABORATIVE, INTEGRATED CROSS-PROJECT APPROACHES THAT PRODUCE NEW HUMAN MODELS OF GENETIC AIRWAY AND ALVEOLAR DISEASES, AND WILL APPLY THESE IN VITRO IPSC AND ORGANOID-BASED MODELS TO UNDERSTAND BASIC PATHOGENIC MECHANISMS THAT LEAD FROM EPITHELIAL DYSFUNCTION TO LUNG DISEASE. AIM 2 WILL IDENTIFY POTENTIAL THERAPEUTIC STRATEGIES ABLE TO REVERSE OR AMELIORATE ABERRANT PATHWAYS RESPONSIBLE FOR THE ALVEOLAR DYSFUNCTION PRESENT IN GENETIC DISEASES THAT AFFECT THE DISTAL LUNG, INCLUDING PROTEOSTASIS, MITOCHONDRIAL DYSFUNCTION, AND METABOLIC CHANGES THAT WE HYPOTHESIZE LEAD TO REVERSIBLE EPITHELIAL TOXIC GAIN-OF-FUNCTION PHENOTYPES. AIM 3 WILL DEVELOP A FUTURE APPROACH FOR TREATING GENETIC LUNG DISEASES BASED ON THE IN VIVO RECONSTITUTION OF AIRWAY AND ALVEOLAR STEM CELL COMPARTMENTS VIA INTRA-AIRWAY TRANSPLANTATION OF PLURIPOTENT STEM CELL-DERIVED AIRWAY BASAL OR DISTAL ALVEOLAR EPITHELIAL CELLS.

HOME INVESTMENT CPD

HEALTHY START INITIATIVE

HOME INVESTMENT PARTNERSHIPS PROGRAM

NEURAL SUBSTRATES OF COGNITIVE DECLINE IN AGING MONKEYS

PUBLIC AND INDIAN HOUSING

GENETIC STUDIES OF ALZHEIMER'S DISEASE IN JEWISH AND ARAB POPULATIONS - MOST DISCOVERIES OF THE GENETIC BASIS OF ALZHEIMER DISEASE (AD) WERE MADE IN CAUCASIANS OF EUROPEAN ANCESTRY (EAS) AND REQUIRED SAMPLES BETWEEN 10,000 AND 150,000 SUBJECTS TO DETECT THEM. WE AND OTHERS HAVE DEMONSTRATED THAT DISCOVERY OF AD RISK VARIANTS CAN BE ACCOMPLISHED IN MORE GENETICALLY HOMOGENEOUS COHORTS COMPRISING SEVERAL THOUSAND OR FEWER SUBJECTS. STUDIES OF NON-EA POPULATIONS ALSO AFFORD THE OPPORTUNITY TO DISCOVER VARIANTS THAT ARE RELATIVELY RARE OR ABSENT IN EAS AND THAT DISPLAY A SMALLER EFFECT SIZE IN EAS DUE TO MODIFICATION BY OTHER GENES AND ENVIRONMENTAL FACTORS. WE WILL FOCUS ON JEWS AND ARABS CURRENTLY LIVING IN ISRAEL WHO ARE DESCENDED FROM THE MIDDLE EAST AND NORTH AFRICA (MENA). ALTHOUGH MENA JEWS ASSIMILATED TO SOME EXTENT WITH THEIR NON-JEWISH NEIGHBORS, THEY HAVE MAINTAINED A DISTINCTIVE GENETIC PROFILE THAT REFLECTS SOME ADMIXTURE WITH NON-JEWS, ANCIENT JEWISH BACKGROUND, AND A UNIQUE COMPONENT REFLECTING GENETIC DRIFT AND NEW MUTATIONS DURING THE LAST TWO MILLENNIA. OUR PREVIOUS STUDIES OF ARABS LIVING IN THE ISRAELI VILLAGE CALLED WADI ARA REVEALED A GENOME-WIDE SIGNIFICANT ASSOCIATION FOR AD WITH ACE, WERE CENTRAL TO THE ESTABLISHMENT OF SORL1 AS AN AD GENE, AND CONTRIBUTED TO A TRANS-ETHNIC GWAS LEADING TO THE DISCOVERY OF SEVERAL NOVEL AD GENES. IN THIS PROJECT, WE WILL LEVERAGE THE GENETIC ARCHITECTURE OF MENA JEWS AND ISRAELI-ARABS, AS WELL AS THEIR DISTINCTIVE ENVIRONMENTAL EXPOSURES AND LIFESTYLES, TO PROMOTE DISCOVERY OF AD-RELATED GENES AND VARIANTS. SPECIFICALLY, WE WILL RECRUIT 3,000 MENA JEWS AT THREE SITES IN ISRAEL, AS WELL AS 1,000 ISRAELI-ARABS LOCATED IN MULTIPLE VILLAGES (EQUAL NUMBERS OF AD CASES AND CONTROLS IN THE TOTAL SAMPLE). WE WILL OBTAIN FROM EACH PARTICIPANT A BLOOD SPECIMEN FOR DNA AND BIOMARKER STUDIES, AND PHENOTYPIC DATA INCLUDING CLINICAL, COGNITIVE TEST, MEDICAL HISTORY AND LIFESTYLE INFORMATION, AS WELL AS BRAIN MRI DATA FOR A PORTION OF THE SAMPLE. DNA SPECIMENS WILL BE WHOLE GENOME SEQUENCED (WGS). WGS DATA WILL BE PROCESSED USING PIPELINES ESTABLISHED BY THE ALZHEIMER DISEASE SEQUENCING PROJECT (ADSP). WE WILL CONDUCT A GWAS FOR AD USING ADMIXTURE MAPPING AND METHODS FOR SINGLE VARIANT AND GENE-BASED TESTS. TOP-FINDINGS WILL BE REPLICATED IN ASHKENAZI JEWISH AND NON-JEWISH DATASETS ASSEMBLED BY THE ALZHEIMER DISEASE GENETICS CONSORTIUM AND ADSP USING TRANS-ETHNIC ANALYSIS AND APPROACHES THAT FOCUS ON VARIANTS AFFECTING PROTEIN STRUCTURE, TRANSCRIPTION, AND GENE EXPRESSION. WE WILL ALSO CONDUCT GWAS FOR AGE AT ONSET AND AD BIOMARKERS USING SINGLE OUTCOME AND PLEIOTROPY MODELS. NEXT, WE WILL IDENTIFY GENE TARGETS OF THE TOP-RANKED SNPS BY PERFORMING EXPRESSION QUANTITATIVE TRAIT LOCUS ANALYSIS USING LOCALLY DERIVED AND PUBLICLY AVAILABLE DATA CONTAINING GENOTYPE AND GENE EXPRESSION DATA IN BRAIN AND OTHER TISSUES, AND ESTABLISH FUNCTIONAL CONNECTIONS AMONG THE TOP-RANKED SNPS AND GENES USING PATHWAY, CO- EXPRESSION NETWORK, AND MENDELIAN RANDOMIZATION ANALYSIS. FINALLY, WE WILL EVALUATE THE ASSOCIATION OF VIRUSES DETECTED IN WGS DATA WITH AD USING MACHINE LEARNING METHODS AND REGRESSION MODELS. WE EXPECT THAT THIS PROJECT WILL IDENTIFY NOVEL TARGETS FOR DEVELOPMENT OF EFFECTIVE DRUGS TO TREAT OR RETARD PROCESSES LEADING TO AD.

PUBLIC AND INDIAN HOUSING

GLOBIN GENE EXPRESSION IN SICKLE CELL GENOTYPE-SPECIFIC IPS CELLS

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

HOMELESS PREVENTION & REHSNG

BOSTON COMMUNITY HEALTH WORKERS FOR COVID RESPONSE AND RESILIENT COMMUNITIES (CCR)

GROUP-BASED MINDFULNESS FOR PATIENTS WITH CHRONIC LOW BACK PAIN IN THE PRIMARY CARE

PUBLIC AND INDIAN HOUSING

PERFORM FUNDING SYS

CCE PATHWAY TO PROSPECTIVE EDUCATOR SUCCESS

TEACHER QUALITY PARTNERSHIPS GRANTS

PUBLIC AND INDIAN HOUSING

BOSTON UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD (CTSA) PROGRAM UL1