Queens

NCIC CLINICAL TRIALS GROUP - CANADIAN COLLABORATING CLINICAL TRIALS NETWORK

HEALTH CENTER CLUSTER

3100-1507 QUEENS CARBON, INC., NEW AWARD SCALEUP 2023 PROJECT TITLE: CEMENT DECARBONIZATION VIA ENGINEERED SCM PRODUCTION THIS COOPERATIVE AGREEMENT IS AWARDED TO QUEENS CARBON, INC. INVOLVES SCALING UP THE Q-SYSTEM TO A PILOT PLANT CAPABLE OF PRODUCING 5-10 TONNES OF SCM PER DAY. THE GOAL IS TO DEMONSTRATE THE ECONOMIC AND ENVIRONMENTAL VIABILITY OF THIS TECHNOLOGY AND ITS EASE OF INTEGRATION INTO EXISTING CEMENT PRODUCTION INFRASTRUCTURE FOR A PROJECT IS ENTITLED, “CEMENT DECARBONIZATION VIA ENGINEERED SCM PRODUCTION”

CANADA CLINICAL TRIALS GROUP CONTRIBUTION TO NCI PROGRAM

CAPITAL DEVELOPMENT

HEERA INSTITUTIONAL FUNDING TO HELP ALLEVIATE THE FINANCIAL IMPACT OF THE EXECUTIVE ORDERS LEADING TO THE SHUTTING DOWN OF CAMPUS OPERATIONS AS A RESULT OF THE CORONAVIRUS PANDEMIC.

FINANCIAL RELIEF FOR STUDENTS IMPACTED ADVERSELY BY THE NEED TO MOVE FROM AN ON-CAMPUS HIGHER EDUCATION ENVIRONMENT TO A REMOTE, DISTANCE LEARNING ENVIRONMENT.

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

COMPREHENSIVE HIGH-IMPACT HIV PREVENTION PROJECTS FOR COMMUNITY-BASED ORGANIZATIONS

O2 SENSING IN THE DUCTUS ARTERIOSUS

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

PROTEOME-WIDE CELLULAR IMMUNITY APPROACH TO P. FALCIPARUM ANTIGEN IDENTIFICATION

NEXT-GENERATION PEPTIDE-BASED MEDICINES FOR MALARIA

LACE-BIO-II: IDENTIFICATION, VALIDATION AND IMPLEMENTATION OF PROGNOSTIC AND/OR P

STRENGTHENING INSTITUTIONS PROGRAM (SIP)

GENETIC INFLUENCES ON THE BRAIN: A TWIN IMAGING STUDY

HUMAN-INFORMED DATA-DRIVEN DEVELOPMENT OF NEXT-GENERATION T CELL VACCINE AGAINST MALARIA - PA-19-077 DOOLAN: PROJECT SUMMARY MALARIA REMAINS A GLOBAL PUBLIC HEALTH PROBLEM WITH NEARLY HALF OF THE WORLD'S POPULATION AT RISK. AN EFFECTIVE MALARIA VACCINE WOULD PREVENT ALMOST HALF A MILLION DEATHS AND OVER 200 MILLION CLINICAL CASES EACH YEAR AND HELP ERADICATE THE DISEASE. THE MOST EFFECTIVE EXPERIMENTAL MALARIA VACCINATION REGIMENS TO DATE ARE RADIATION- ATTENUATED SPOROZOITES (RAS; PFSPZ) AND INFECTIOUS SPOROZOITES ADMINISTERED UNDER CHEMOPROPHYLAXIS (CPS). PROTECTIVE IMMUNITY IS BELIEVED TO BE MEDIATED BY CD8+ T CELLS WHICH ATTACK THE PARASITE DURING THE PRE- ERYTHROCYTIC (PE) LIVER-STAGE OF INFECTION. HOWEVER, THE KEY ANTIGENS UNDERLYING THIS PROTECTION ARE LARGELY UNKNOWN. WE HAVE DEVELOPED AND APPLIED A PROTEOME-WIDE T CELL SCREENING APPROACH TO IDENTIFY THE SUBSET OF KEY ANTIGENS TARGETED BY T CELL RESPONSES FROM THE COMPLETE PLASMODIUM FALCIPARUM PARASITE PROTEOME. WE HAVE SHOWN THAT THE ANTIGENS PREFERENTIALLY RECOGNIZED BY T CELLS ARE DISTINCT FROM ANTIBODY TARGETS. HERE, WE WILL CHARACTERIZE AND CREDENTIAL HIGHLY RANKED PRE-ERYTHROCYTIC P. FALCIPARUM T CELL ANTIGENS FROM OUR UNIQUE DATASET, FOCUSING ON THOSE THAT ARE CATEGORIZED AS EXCLUSIVELY T CELL TARGETS, SINCE T CELLS DIRECTED AGAINST LIVER- STAGE ANTIGENS ARE CONSIDERED THE PRIMARY IMMUNE EFFECTORS REQUIRED FOR STERILE IMMUNITY AGAINST MALARIA WHICH PREVENTS DISEASE AND STOPS TRANSMISSION. OUR SELECTION CRITERIA WILL CONSIDER EXTENT OF SEQUENCE CONSERVATION ACROSS PLASMODIUM STRAINS AND SPECIES, TO TARGET A VACCINE THAT CONFERS STRAIN TRANSCENDING AND CROSS-SPECIES PROTECTION. WE WILL USE CLINICALLY RELEVANT SELECTION CRITERIA GOVERNED BY THE CAPACITY OF THE ANTIGEN TO PROTECT AGAINST VIRULENT P. YOELII PARASITE CHALLENGE IN ESTABLISHED PRECLINICAL MODELS AND TO BE RECOGNIZED BY RECALL PLASMODIUM-SPECIFIC IMMUNE RESPONSES IN PROTECTIVE HUMAN MODELS. WE WILL USE TWO INNOVATIVE VACCINE DELIVERY PLATFORMS SELECTED FOR CAPACITY TO INDUCE ROBUST AND SUSTAINED T CELL RESPONSES, WITH A SPECIFIC FOCUS ON THE INDUCTION OF LIVER-SPECIFIC RESIDENT MEMORY T CELLS (TRM) TARGETING THE PUTATIVE SITE OF IMMUNE ACTION. OUR SELECTED REGIMENS INCLUDE “PRIME-TARGET” COMPRISING A DNA PRIME FOLLOWED BY ADENOVIRUS BOOST DELIVERED INTRAVENOUSLY TO TARGET THE LIVER, AND A LIPOSOMAL MRNA VACCINE PLATFORM WITH AN INCORPORATED AGONIST (CA) TO ACTIVATE NKT CELLS AND LINK INNATE AND ADAPTIVE IMMUNITY; BOTH PLATFORMS CAN INDUCE SUSTAINED T CELL RESPONSES AND ARE CAPABLE OF PROTECTING MICE AGAINST SPOROZOITE CHALLENGE. WE WILL ASSIGN PRIORITIES FOR VACCINE DEVELOPMENT ACCORDING TO THEIR CREDENTIALS, EVALUATE COMBINATIONS FOR SYNERGY, AND DOWN-SELECT FOR CLINICAL DEVELOPMENT THE SET OF ANTIGENS THAT HAVE A MAXIMUM LIKELIHOOD OF INDUCING ROBUST AND SUSTAINED PROTECTIVE IMMUNITY AGAINST MALARIA IN HUMANS. THE OPTIMAL VACCINE CANDIDATE DEFINED WITH THIS PRECLINICAL DEVELOPMENT STRATEGY COULD BE TRANSITIONED DIRECTLY TO CLINICAL DEVELOPMENT WITH THE ULTIMATE GOAL OF DEPLOYING IN THE FIELD AN EFFECTIVE RATIONALLY-DESIGNED GENOME-BASED VACCINE THAT WOULD INDUCE DURABLE T-CELL MEDIATED PROTECTION AND AMELIORATE DISEASE IN ALL AT-RISK INDIVIDUALS.

THE PURPOSE OF THIS COOPERATIVE AGREEMENT IS TO FUND RESEARCH IN SUPPORT OF BTO IN THE AMOUNT OF 1,025,290 ON CONTRACT HR0011-17-2-0036.

DRUGS FROM BUGS: DEVELOPING NEW INFLAMMATORY BOWEL DISEASE DRUGS FROM GUT BACTERIA-DERIVED BIOACTIVES

WHAT CAUSES LOW BACK PAIN TO FLARE: HAS A MAJOR OPPORTUNITY TO UNDERSTAND BACK PAIN BEEN MISSED? - PROJECT SUMMARY/ABSTRACT LOW BACK PAIN (LBP) IS TRADITIONALLY VIEWED AS EITHER A TRANSIENT CONDITION WITH ACUTE EPISODES OR A CHRONIC PERSISTING CONDITION. HOWEVER, IT IS INCREASINGLY RECOGNIZED THAT FOR MOST (>80% OF CASES), LBP HAS A VARIABLE AND ONGOING TRAJECTORY CHARACTERIZED BY FLUCTUATING SYMPTOMS – WITH PERIODS OF WORSE SYMPTOMS REFERRED TO AS “FLARES”. CURRENT WORK REGARDING RISK FACTORS FOR LBP ONLY CONSIDERS THOSE ASSOCIATED WITH A NEW EPISODE OR THE TRANSITION TO CHRONIC LBP. FINDINGS FROM THAT WORK HAS FAILED TO DELIVER EFFECTIVE STRATEGIES TO PREVENT NEW EPISODES OR CHRONICITY, NOR REDUCE THE EXCESSIVE BURDEN OF LBP. THE UNDERLYING PREMISE OF THIS PROPOSAL IS THAT FLUCTUATION OR FLARING OF LBP IS MEDIATED BY TRANSIENT/FLUCTUATING EXPOSURE TO A RANGE OF FACTORS ACROSS MULTIPLE DOMAINS, THAT DIFFER BETWEEN INDIVIDUALS, AND IDENTIFICATION OF THESE FACTORS COULD PROVIDE A BASIS FOR A COMPLETELY NEW MODEL TO PERSONALIZE CARE. THIS PROJECT WILL TAKE A FRESH LOOK AT LBP BY DIRECTLY ADDRESSING THIS QUESTION USING INNOVATIVE METHODS THAT ARE ENABLED BY RECENT ADVANCES IN TECHNOLOGY. THE WORK IS BASED ON OUR EXTENSIVE COLLABORATION WITH PEOPLE WITH LBP THAT HAS PROVIDED CRITICAL INSIGHT INTO HOW FLARES ARE DEFINED (WHICH SURPRISINGLY IS NOT BASED ON PAIN ALONE) AND THEIR PERSPECTIVE OF THE POTENTIAL CAUSES FOR LBP FLARES. OUR MULTIDISCIPLINARY RESEARCH TEAM PROPOSE AN INNOVATIVE CASE-CROSSOVER STUDY THAT WILL ADDRESS TWO AIMS. AIM 1 WILL EXAMINE, AT MULTIPLE TIMEPOINTS OVER A PERIOD OF 3 MONTHS, AN ARRAY OF CANDIDATE BIOLOGICAL/BEHAVIORAL, PSYCHOLOGICAL, SOCIAL, AND ENVIRONMENTAL RISK FACTORS FOR LBP FLARE THAT HAVE BEEN SELECTED BASED ON CONSUMER PERSPECTIVE, LITERATURE REVIEW AND OUR EXTENSIVE PRELIMINARY STUDIES. MEASURES WILL BE MADE IN THE “REAL WORD” USING ADVANCED WEARABLE AND ONLINE TECHNOLOGIES. AIM 2 WILL INVOLVE AN EMBEDDED STUDY OF INDIVIDUALS FROM THE MAIN PARTICIPANT COHORT WHO FLARE FREQUENTLY. FOR 7 DAYS, ELIGIBLE INDIVIDUALS WILL UNDERGO MORE INTENSIVE “REAL- WORLD” PHYSIOLOGICAL AND BIOMECHANICAL MEASURES USING AN INNOVATIVE COMBINATION OF WEARABLE SENSORS AND HOME-BASED SAMPLE/DATA COLLECTION TO INVESTIGATE POTENTIAL MECHANISMS UNDERLYING TWO SURPRISING PRELIMINARY OBSERVATIONS: (1) THAT POOR SLEEP IS A POTENT RISK FACTOR FOR A SUBSEQUENT FLARE (AS OPPOSED TO THE TRADITIONAL VIEW THAT PAIN INTERFERES WITH AND CAUSES POOR SLEEP), AND (2) THAT LOW RATHER THAN HIGH PHYSICAL ACTIVITY IS A RISK FACTOR FOR LBP FLARE. WE AIMS TO IDENTIFY NOT ONLY IF, BUT HOW, DAILY VARIATIONS IN SLEEP QUALITY AND PHYSICAL ACTIVITY – TWO OF THE MOST IMPORTANT, YET MODIFIABLE HEALTH BEHAVIORS – DRIVE FLARE OF LBP. TOGETHER THESE DATA WILL FILL A MAJOR GAP BY PROVIDING NEW UNDERSTANDING OF MECHANISMS THAT DRIVE THE FLUCTUATING EXPERIENCE OF LBP. SUCH FACTORS WILL PROVIDE THE FOUNDATION TO DEVELOP AND TEST MORE TARGETED AND PERSONALIZED INTERVENTIONS TO REDUCE THE ENORMOUS – AND WORSENING – BURDEN OF THIS CONDITION ON SUFFERERS AND SOCIETY.

LONG-TERM ETHANOL EXPOSURE AND NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS

LEGAL ASSISTANCE FOR VICTIMS GRANT PROGRAM

VITAMIN C IN THERMAL INJURY: THE VICTORY TRIAL

DISCOVERY OF NEW TREATMENTS AND BIOMARKERS FOR NEUROGENIC HETEROTOPIC OSSIFICATIONS FOLLOWING SPINAL CORD INJURIES

NOVEL THERAPEUTIC TARGETING OF NEUROTOXIC GUT MICROBIOTA-DERIVED METABOLITES IN PARKINSON'S DISEASE

PEPTIDE INHIBITORS TARGETING SODIUM CHANNELS TO TREAT AMYOTROPHIC LATERAL SCLEROSIS

DOMESTIC WATER GRANTS - REGULAR

SPINEPASS: SPINE SELF-MANAGEMENT TECHNIQUES FOR PERSISTENT HEADACHE AFTER CONCUSSION-PHYSICAL THERAPY TARGETING AUTONOMIC AND DURA MATER FUNCTION

RECOVERY ACT HEALTH CENTER CLUSTER PROGRAM

YOUTH BUILD

ELUCIDATING SENSORIAL AND FUNCTIONAL CHARACTERISTICS OF TOPICAL FORMULATIONS

THE EXPANSION AND REPLICATION OF CENTRAL QUEENS ACADEMY

TOPICAL VENOM ACTIVATED HYDROGEL HEMOSTATIC (PROCOAGULANT + ANTIFIBRINOLYTIC) AGENT

DEVELOPMENT AND TRANSLATION OF A MULTIMODAL THERAPEUTIC AGENT AND MEDICAL COUNTERMEASURE FOR THE TREATMENT OF MILITARY-RELATED TOXIC EXPOSURES

ACCELERATING TRANSLATION OF A NOVEL METAP2 INHIBITOR IN TREATMENT-RESISTANT AND AGGRESSIVE-VARIANT PROSTATE CANCER

THERAPEUTIC RESOLUTION OF INFLAMMATION AND NEUROTOXICITY AT THE GUT-BRAIN AXIS FOR DISEASE MODIFICATION IN PARKINSON'S DISEASE

THE NOSE KNOWS: HARNESSING HUMAN OLFACTORY CELLS TO IDENTIFY BIOMARKERS OF NONMOTOR CHANGES IN PARKINSON'S DISEASE

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

ACCELERATING THE PRECLINICAL TESTING OF A PROMISING TARGETED THERAPEUTIC FOR TRIPLE-NEGATIVE BREAST CANCER

PREDICTING EARLY-STAGE MELANOMA AT HIGH RISK OF RECURRENCE THROUGH MULTIOMICS PROFILING

ASIAN DOMESTIC VIOLENCE LAW COLLABORATIVE

A FIRST-IN-CLASS CALCIUM CHANNEL INHIBITOR FOR THE TREATMENT OF ADVANCED METASTATIC PROSTATE CANCERS RESISTANT TO NEXT-GENERATION ANTIANDROGEN THERAPY

PROTEOMIC BIOMARKERS FOR ALS DISEASE PROGNOSIS AND PROGRESSION MONITORING.

YOUTH BUILD

OPTIMAL DOSE, VOLATILE PYRETHROIDS FOR PREVENTION OF BITING INSECTS.

PATHWAYS FROM GENOTYPE AND ENVIRONMENT TO MELANOMA

EXPLOITING THE REMODELING OF CA2+ SIGNALING IN BREAST CANCER CELL MICROENVIRONMENTS TO CONTROL METASTASIS AND TO SPECIFICALLY TARGET BRAIN METASTASES

THE ROLE OF DRP-1 AND MITOCHONDRIAL FISSION IN PULMONARY ARTERIAL HYPERTENSION

PRECLINICAL VALIDATION OF A NOVEL DRUG LEAD TO TREAT TUBERCULOSIS

CAROL M. WHITE PHYSICAL EDUCATION PROGRAM

ASIAN BATTERED WOMEN'S PROJECT

EXPANSION OF THE MAPP RESEARCH NETWORK: MICROBIAL AND BIOPSYCHOSOCIAL CONTRIBUTIO

TAS::57 3600::TAS "BASIC RESEARCH FOR AOARD 144046 "QUANTUM MICRORHEOLOGY, DATED 15 JAN 14" (THE GRANTEE'S TECHNICAL PROPOSAL)"

UNDERSTANDING ACUTE TO CHRONIC BACK PAIN PATHWAYS AND TESTING NEW SOLUTIONS. NEW AWARD.

CHILDREN'S LIBRARY DISCOVERY CENTER (CLDC): 'SCIENCE IN THE STACKS'

FY23 CONGRESSIONAL COMMUNITY PROJECT FOR CHAMBER OF COMMERCE OF THE BOROUGH OF QUEENS 1MIL

WASTE DISPOSAL GRANTS - REGULAR

WASTE DISPOSAL GRANTS - REGULAR

EXPLOITING THE REMODELING OF CA2+ SIGNALING IN BREAST CANCER CELL MICROENVIRONMENTS TO CONTROL METASTASIS AND TO SPECIFICALLY TARGET BRAIN METASTASES

2/3 EATING DISORDERS GENETICS INITIATIVE 2 - PROJECT SUMMARY WE PROPOSE THE EATING DISORDERS GENETICS INITIATIVE 2 (EDGI2), A NEW COLLABORATIVE R01 IN RESPONSE TO PAR- 23-050 CLINICAL STUDIES OF MENTAL ILLNESS. ITS SINGLE-SITE PREDECESSORS, EDGI1 (R01 MH120170) AND ARFID-GEN (R56 MH129437) HAVE BEEN RESOUNDINGLY SUCCESSFUL. WE NOW UNITE THE FOUR ORIGINAL EDGI1 SITES WITH EXCEPTIONALLY PRODUCTIVE GLOBAL NEW SITES TO ADVANCE GENOMIC DISCOVERY ACROSS ALL MAJOR EATING DISORDERS (EDS) TO IDENTIFY BIOLOGICALLY, CLINICALLY, CULTURALLY, AND THERAPEUTICALLY MEANINGFUL AND ACTIONABLE INSIGHTS. AIM 1: EDGI2 EXTENDS OUR CORE BUSINESS BY INCREASING SAMPLE SIZE, DIVERSITY, AND ED PHENOTYPES. USING OUR COMPREHENSIVE HARMONIZED ONLINE ASSESSMENT BATTERY, WE WILL PHENOTYPE AND BIO-SAMPLE 20,000 NEW PARTICIPANTS WITH ANOREXIA NERVOSA (AN), BULIMIA NERVOSA (BN), BINGE-EATING DISORDER (BED), AVOIDANT/RESTRICTIVE FOOD INTAKE DISORDER (ARFID), AND CONTROLS. EDGI2 EMPHASIZES CO-PRODUCTION—WITH REPRESENTATIVES FROM MINORITIZED AND MARGINALIZED COMMUNITIES, WE WILL ASCERTAIN 30% OF SAMPLES FROM UNDERREPRESENTED GROUPS. WE WILL ALSO OVER- SAMPLE INDIVIDUALS WITH SEVERE AND ENDURING AN (SE-AN), WHOSE DNA MAY BE ENRICHED FOR CAUSATIVE ALLELES. AIM 2: WE WILL APPLY STATISTICAL GENETIC ANALYSES TO EXPLICATE HETEROGENEITY AND BIOLOGY OF EDS BY: CONDUCTING STANDARD GWAS ANALYSES ON DIAGNOSES, TRANS-DIAGNOSTIC BEHAVIORS, AND CONTINUOUS PHENOTYPES INCLUDING POLYGENIC RISK SCORE (PRS), AND RARE VARIANT CNV ANALYSES; IDENTIFYING CLINICALLY MEANINGFULLY PATIENT SUBSETS; AND INTENSIVELY EVALUATING OUR PROPOSAL THAT AN IS A METABO-PSYCHIATRIC DISORDERS USING LDSC, PRSET, PHEWAS, AND MENDELIAN RANDOMIZATION TO CLARIFY DIRECTION OF CAUSATION. AIM 3: WE WILL EVALUATE THE RELATIVE ROLES OF GENETIC AND ENVIRONMENTAL RISK AND RESILIENCE FACTORS TO INFORM RISK PREDICTION BY PHENOTYPICALLY CHARACTERIZING CASES AND CONTROLS WITH HIGH AND LOW PRS FOR EDS AND THEN BY GENOTYPICALLY CHARACTERIZING THOSE WITH SEVERE ED PHENOTYPES. WE WILL CHARACTERIZE DISTINCT GENETIC OR MOLECULAR GROUPINGS/PATTERNS ACROSS CASES AND CONTROLS AND PHENOTYPICALLY CHARACTERIZE IDENTIFIED MOLECULAR SUBTYPES. AIM 4: TO DETERMINE WHERE IN THE BODY EDS “LIVE”, WE WILL IDENTIFY BRAIN CELL TYPES AND ANATOMICAL REGIONS IMPLICATED BY GENOMIC STUDIES OF EDS; PREDICT GENETICALLY REGULATED GENE EXPRESSION (GREX) IN BRAIN, GUT, ADIPOSE, AND OTHER ED-RELEVANT TISSUES; USE SNRNASEQ ATLASES TO SHARPEN PRELIMINARY GTEX AND TWAS ANALYSES TO IDENTIFY BRAIN CELL TYPES STRONGLY IMPLICATED BY THE GENOMICS OF EACH ED; EXPAND TO RELEVANT NON-BRAIN CELL TYPES (E.G., ADIPOSE, MUSCLE, LIVER, SALIVARY); AND USE DYNAMIC GREX TO MODEL GENE EXPRESSION IN ED-RELEVANT CONTEXTS (E.G., SEX, BMI, STRESS) ENABLING PRECISE AND PERSONALIZED MODELLING OF GENE EXPRESSION. AIM 5: EDGI2 WILL CULMINATE IN A TRANSLATIONAL SUMMIT UNITING FORWARD-THINKING STAKEHOLDERS FROM MULTIPLE SECTORS TO DEVELOP A TRANSLATIONAL ROADMAP FOR EVIDENCE-BASED ED PREVENTION AND TREATMENT. EDGI2 WILL YIELD CRITICAL KNOWLEDGE ABOUT GENETIC AND ENVIRONMENTAL RISK FOR EDS, REVEAL MECHANISMS THAT POTENTIATE OR PROTECT AGAINST GENETIC RISK, AND TRANSITION ED GENETICS FROM DISCOVERY TO CLINICAL TRANSLATION.

MICROBES THAT MATTER: DEFINING OPTIMAL FORMULATIONS FOR MICROBIAL ECOSYSTEM THERAPEUTICS

RAPID AND NOVEL SURVEILLANCE TOOL FOR DETECTING ARBOVIRUS TRANSMISSION HOTSPOTS IN BRAZIL

DISCOVERY OF POLYMYXIN-BASED ANTIBACTERIAL AGENTS ACTIVE AGAINST MULTI-DRUG RESIS

ARRA - CAPITAL IMPROVEMENT PROGRAM

AFPMB DWFP GRANT AWARD

TARGETING THE DYSREGULATION OF ADIPONECTIN AS A NOVEL PROSTATE CANCER THERAPY

INVESTIGATING THE ROLE OF NOVEL TRANSCRIPTS IN THE MYCN LOCUS DRIVING NEUROENDOCRINE PROSTATE CANCER

A NOVEL TARGETED THERAPY FOR TREATMENT-EMERGENT ANAPLASTIC FORMS OF CASTRATION-RESISTANT PROSTATE CANCER

MURINE ATLAS OF GENITOURINARY DEVELOPMENT

CONGRESSIONALLY DIRECTED SPENDING GRANT - WATER

MODULATION OF CELL SIGNALING PATHWAYS BY ALPHAHERPESVIRUS TEGUMENT COMPONENTS

ARRA - INCREASE SERVICES TO HEALTH CENTERS

ENDOMETRIOSIS SUSCEPTIBILITY GENES IN ENDOMETRIAL STEM/PROGENITOR CELLS

ENHANCEMENT OF NATURAL KILLER CELL FUNCTION FOR THERAPEUTIC TARGETING AND ELIMINATION OF METASTATIC BREAST CANCER

PREVENTION NAVIGATION FOR RACIAL AND ETHNIC MINORITIES IN QUEENS

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

THE LEGAL ASSISTANCE FOR VICTIMS (LAV) GRANT PROGRAM, AUTHORIZED BY 34 U.S.C. 20121, IS INTENDED TO INCREASE THE AVAILABILITY OF CIVIL AND CRIMINAL LEGAL ASSISTANCE NEEDED TO EFFECTIVELY AID VICTIMS (AGES 11 AND OLDER) OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING BY PROVIDING FUNDS FOR COMPREHENSIVE DIRECT LEGAL SERVICES TO VICTIMS IN LEGAL MATTERS RELATING TO OR ARISING OUT OF THAT ABUSE OR VIOLENCE. LEGAL ASSISTANCE INCLUDES ASSISTANCE TO VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING IN: A) FAMILY, TRIBAL, TERRITORIAL, IMMIGRATION, EMPLOYMENT, ADMINISTRATIVE AGENCY, HOUSING MATTERS, CAMPUS ADMINISTRATIVE, OR PROTECTION OR STAY AWAY ORDER PROCEEDINGS, AND OTHER SIMILAR MATTERS; B) CRIMINAL JUSTICE INVESTIGATIONS, PROSECUTIONS, AND POST-TRIAL MATTERS (INCLUDING SENTENCING, PAROLE, AND PROBATION) THAT IMPACT THE VICTIMS SAFETY AND PRIVACY; C) ALTERNATIVE DISPUTE RESOLUTION, RESTORATIVE PRACTICES, OR OTHER PROCESSES INTENDED TO PROMOTE VICTIM SAFETY, PRIVACY, AND AUTONOMY; AND D) POST-CONVICTION RELIEF PROCEEDINGS IN STATE, LOCAL, TRIBAL, OR TERRITORIAL COURT WHERE THE CONVICTION OF A VICTIM IS RELATED TO OR ARISING FROM DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, STALKING, OR SEX TRAFFICKING. 34 U.S.C. 12291(A)(24)(C) AND (D). THROUGH THIS CONTINUATION LEGAL ASSISTANCE FOR VICTIMS PROJECT, DAY ONE NEW YORK, INC., IN PARTNERSHIP WITH THE NEW YORK CITY ALLIANCE AGAINST SEXUAL ASSAULT AND THE DOOR, WILL PROVIDE LEGAL ASSISTANCE TO YOUTH VICTIMS OF SEXUAL ASSAULT AND INTIMATE PARTNER VIOLENCE IN NEW YORK CITY. THE PROJECT WILL ADDRESS THE FOLLOWING PRIORITY AREA: INCREASE LEGAL SERVICES TO VICTIMS OF SEXUAL ASSAULT. THE FOLLOWING PRODUCTS WILL BE DEVELOPED DURING THE PROJECT PERIOD: REVISED AND UPDATED KNOW YOUR RIGHTS GUIDES IN ENGLISH AND SPANISH. THIS AWARD IS A CONTINUATION OF 2017-WL-AX-0018.

DISCOVERING THERAPEUTIC VULNERABILITIES OF CIRCULATING MELANOMA CLUSTERS

AUDITORY SPEECH PROCESSING IN THE PERCEPTION AND PRODUCTION OF VOWELS

UNDERSTANDING THE ROLE OF IMMATURE MYELOID CELLS IN EARLY MELANOMA ESTABLISHMENT

MELANOMA RESEARCH PROGRAM

THE SHORT AND THE LONG OF A GWAS IDENTIFIED LONG NON-CODING RNA

ZIKA: A FAST NEW INTERVENTION AND AN INNOVATIVE METHOD OF EVALUATION

THERAPEUTIC INHIBITION OF NEUTROPHIL ACTIVITY AS A DISEASE-MODIFYING TREATMENT FOR AMYOTROPHIC LATERAL SCLEROSIS

PS04-064 HUMAN IMMUNODEFICIENCY VIRUS(HIV)PREVENTION PROJECTS FOR CBO

QUANTUM CONTROL OF BIOMOLECULAR VIBRATIONS

DANGER SIGNALING, TRAUMATIC BRAIN INJURY, AND EPILEPTOGENESIS.

HIGH IMPACT HIV PREVENTION FOR PERSONS OF COLOR IN QUEENS

DECIPHERING AND INTERCEPTING MESSAGES BETWEEN CANCER CELLS AND CELLS IN THE BREAST CANCER MICROENVIRONMENT: ROLES FOR INTRACELLULAR CALCIUM SIGNALING

MECHANISMS AND TREATMENTS OF HETEROTOPIC OSSIFICATION FOLLOWING SPINAL CORD INJURIES

THE ROLE OF THE ATM GENE IN FAMILIAL BREAST CANCER

RP-115: A NOVEL BIOMARKER OF ASTROCYTE DYSFUNCTION AND GLUTAMATE DYSREGULATION IN BRAIN AND SPINAL CORD IN ALS

INVESTIGATING THE INFLUENCE OF TAILORED WALL TEMPERATURE PROFILING ON HYPERSONIC BOUNDARY LAYER TRANSITION

IDENTIFYING SUSCEPTIBILITY GENES FOR ENDOMETRIOSIS

ADVANCED PATIENT-DERIVED MICROGLIA ASSAY FOR PRECLINICAL AND CLINICAL TRIAL DRUG VALIDATION

TAS::57 3600::TAS "LEARNING TO FLY: USING DISTRIBUTED PRESSURE SENSING AND NETWORK STRATEGIES FOR CONTROL IN GUSTY ENVIRONMENTS" THE GRANTEE'S TECHNICAL PROPOSAL DATED

NEW GRANT

NONEQUILIBRIUM QUANTUM DYNAMICS IN SUPERFLUID HELIUM

BASIC RESEARCH FOR AOARD 134134 "RE-ENGINEERING THE STOMATOPOD EYE, NATURE'S MOST COMPREHENSIVE VISUAL SENSOR, DATED 28 MAR 12" (THE GRANTEE'S TECHNI

GENETICS OF SERRATED NEOPLASIA

WOMEN'S EDUCATIONAL EQUITY ACT PROGRAM - IMPLEMENTATION

POPULATING THE WALL LAYER, ONE EDDY AT A TIME: RESOLVENT ANALYSIS FOR WALL-MODELLED LES

PREDICTING EARLY-STAGE MELANOMA AT HIGH RISK OF RECURRENCE THROUGH MULTIOMICS PROFILING

TARGETING COMPLEMENT IN POST-TRAUMATIC EPILEPTOGENSIS

EXPERIMENTAL STUDY OF NON-EQUILIBRIUM TURBULENCE-CHEMISTRY INTERACTION IN EXTERNAL HYPERSONIC FLOWS

IDENTIFYING AND VALIDATING ONCOGENE-INDUCED MECHANISMS OF IMMUNOSUPPRESSION DOWNSTREAM OF THE ESRP1/FGFR2/KRAS AXIS TO IMPROVE IMMUNOTHERAPY

CLEC9A TARGETING ANTIBODIES AS A NEW IMMUNOTHERAPY FOR PROSTATE CANCER

A NOVEL MEDIATOR OF CHOLANGIOCARCINOMA THAT HAS POTENTIAL AS A DIAGNOSTIC AND TREATMENT TARGET

THE PURPOSE OF THIS AGREEMENT IS TO DISTRIBUTE PANDEMIC MARKET VOLATILITY ASSISTANCE PROGRAM MONIES TO DAIRY FARMERS WHO RECEIVED A LOWER VALUE DUE TO MARKET ABNORMALITIES CAUSED BY THE PANDEMIC AND ENSUING FEDERAL POLICIES. RECIPIENTS WILL DISBURSE PMVAP MONIES TO ELIGIBLE PRODUCERS. IN ADDITIONAL, RECIPIENTS MUST OBTAIN ADJUSTED GROSS INCOME ATTESTATIONS FROM ELIGIBLE PRODUCERS, ISSUE 1099-MISC TO EACH PRODUCER REFLECTING THEIR PMVAP PAYMENT, PROVIDE DOCUMENTATION PAYMENTS WERE MADE IN ACCORDANCE TO PROGRAM RULES, AND PROVIDE DAIRY POLICY EDUCATION TO ELIGIBLE PRODUCERS. RECIPIENTS WILL DISBURSE ALL PMVAP MONIES TO ELIGIBLE PRODUCERS, PROVIDE AND DOCUMENT DAIRY POLICY EDUCATION EFFORTS, AND BE SUBJECT TO PAYMENT VERIFICATION BY USDA STAFF. DAIRY FARMERS WHOSE MILK WE MARKETED TO A FEDERAL MILK MARKETING ORDER REGULATED HANDLER DURING JULY THROUGH DECEMBER 2020 ARE THE INTENDED BENEFICIARIES. THERE ARE NO SUBRECIPIENT ACTIVITIES.

TARGETING CEP55 IN TRIPLE-NEGATIVE BREAST CANCER

PREDICTING EARLY-STAGE MELANOMA AT HIGH RISK OF RECURRENCE THROUGH MULTIOMICS PROFILING

MULTI-METAL ION CATALYZED ALCOHOLYSIS REACTIONS OF NEUTRAL AND ANIONIC ORGANOPHOSPHORUS COMPOUNDS IN ALCOHOL MEDIA

FORMULATION DRUG PRODUCT QUALITY ATTRIBUTES IN DERMAL PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELS FOR TOPICAL DERMATOLOGICAL DRUG PRODUCTS AND TRANSDERMAL DELIVERY SYSTEMS

FY23 CONGRESSIONAL COMMUNITY PROJECT FOR CHAMBER OF COMMERCE OF THE BOROUGH OF QUEENS 500K

QUEENS ECONOMIC DEVELOPMENT CORP - FY23 CONGRESSIONAL COMMUNITY PROJECT FUNDING

WASTE DISPOSAL GRANTS (MANDATORY FARM BILL)

VARIETY BOYS AND GIRLS CLUB OF QUEENS - TEEN ACADEMY - HEALTH AND WELL-BEING

FOR MANY OPERATING ONES OWN BUSINESS IS THE QUINTESSENTIAL AMERICAN DREAM. WHILE ATTAINABLE, IT IS NOT WITHOUT SIGNIFICANT CHALLENGES. FOR THOSE THAT HAVE BEEN INCARCERATED THE CHALLENGES ARE MULTIPLIED: EDUCATIONAL/KNOWLEDGE GAPS, EXPERIENCE, FINANCIAL BARRIERS, LEGAL ISSUES AND SUPPORT ISSUES.EDUCATION AND WORK EXPERIENCES ARE THE BIGGEST FACTORS.THEQUEENS ECONOMIC DEVELOPMENT CORPORATION (QEDC) IS PREPARED TO ADDRESS THESE OBSTACLES THROUGH A PROGRAMCOMPRISED OF THE FOLLOWING COMPONENTS: RECRUITMENT, ASSESSMENT, COUNSELING, AND MENTORSHIPS. WORKING WITH LOCAL ORGANIZATIONAL PARTNERS THAT PROVIDE COMPREHENSIVE SERVICES FOR THE FORMERLY INCARCERATED, WE WILL RECRUIT AND ASSESS THEIR CLIENTS WHO DESIRE TO OWN AND OPERATE A SMALL BUSINESS. ALL CLIENTS WILL BE REQUIRED TO UNDERGO CLASSES IN BASIC BUSINESS KNOWLEDGE. UPON SATISFACTORY COMPLETION, THEY WOULD ADVANCE TO SPECIALIZED TRAINING IN THEIR SELECTED INTEREST. WHILE WE HAVE CLASSES IN SELECTED FIELDS, MOST TRAINING WILL BE DONE INDIVIDUALLY USING QEDC COUNSELORS. CLIENTS WILL BE ASSIGNED MENTORS. AS MANY FORMERLY INCARCERATED MAY NOT HAVE HAD ROLE MODELS IN THE ENTREPRENEURIAL WORLD, WE BELIEVE THE MENTOR-CLIENT RELATIONSHIP IS VITAL. DURING THE PROGRAM WE WILL COORDINATE ALL EFFORTS WITH OUR PARTNER ORGANIZATIONS THAT PROVIDE SUPPORT IN OTHER AREAS OF THE CLIENTS LIFE. THOUGH THIS GRANT IS FINITE, ALL THOSE WHO PARTICIPATE WILL REMAIN QEDC CLIENTS BEYOND ITS TERM. CLIENTS WILL BE ENCOURAGED TO TAKE ADVANTAGE OF ALL QEDC PROGRAMS IN SERVICES INCLUDING CLASSES, CONTINUED COUNSELING, FUNDING OPPORTUNITIES AND NETWORKING EVENTS AND CLASSES.

ORGANIZATIONS INITIV

ATTENUATED WEST NILE VIRUS VACCINE

SNAKE VENOM-BASED RAPID WOUND SEALANT

PROOF-OF-CONCEPT STUDIES FOR A NOVEL IMMUNOTHERAPY FOR TRIPLE-NEGATIVE BREAST CANCER AND COMPANION DIAGNOSTIC

ENHANCED HYPERSONIC AERODYNAMICS AND STABILITY MODELS THROUGH HARDWARE IN THE LOOP GROUND TESTS IN TUSQ

PROOF-OF-CONCEPT STUDIES FOR A NOVEL IMMUNOTHERAPY FOR TRIPLE-NEGATIVE BREAST CANCER AND COMPANION DIAGNOSTIC

GENETIC VARIATION IN MICRORNA TARGETS IN CANDIDATE GENES FOR MENTAL DISORDERS

WOMEN'S BUSINESS OWNERSHIP ASSISTANCE (BASE RENEWAL)

BASIC RESEARCH FOR AOARD PROPOSAL 20IOA056 "ADVANCED GROUND TESTING AND SIMULATION OF THE BOUNDARY LAYER TRANSITION (BOLT) FLIGHT EXPERIMENT", DATED 1

BASIC RESEARCH FOR AOARD PROPOSAL 20IOA018 "HEATED WALL SUPERSONIC COMBUSTION TESTING OF HYDROCARBONS IN AXISYMMETRIC MODELS IN THE T4/X3R SHOCK TUNNE

THE FRESH PLATE FRESH START PROGRAM OF THE QUEENS ECONOMIC DEVELOPMENT CORPORATION (QEDC) IS A COMMUNITY-DRIVEN PROJECT THAT WILL TRAIN FORMERLY INCARCERATED CLIENTS SO THAT THEY CAN COMMENCE CAREERS IN THE LOCAL FOOD INDUSTRY: RESTAURANTS, MANUFACTURERS AND RETAILERS IN NEED OF SKILLED STAFF. THE COMPONENTS OF THE PROGRAM WILL INCLUDE BASIC TRAINING IN OBTAINING FOOD SAFETY CERTIFICATES, ADVANCED CULINARY TRAINING AS REQUIRED AND ASSISTANCE WITH INTERNSHIPS AND JOB PLACEMENT. THE QEDC WILL PARTNER WITH LOCAL ORGANIZATIONS THAT SUPPORT THE FORMERLY INCARCERATED INCLUDING FORTUNE SOCIETY, HOUR CHILDREN, AND WITNESS TO MASS INCARCERATION. AN IMPORTANT ASPECT WILL BE THE DEVELOPMENT OF A JOBS PORTAL CONNECTING RESTAURANT AND FOOD BUSINESS WITH EMPLOYMENT LISTINGS FOR PROGRAM PARTICIPANTS. SUPERVISED BY A PROGRAM MANAGER, IT WILL ALSO UTILIZE THE RESOURCES OF OUR CURRENT PROGRAMS INCLUDING INSTRUCTORS AND COUNSELORS. TRAINING AND CLASSES WOULD TAKE PLACE AT THE ENTREPRENEUR SPACE, QUEENS ONLY NON-PROFIT COMMERCIAL KITCHEN INCUBATOR. LEARNING ALONGSIDE SMALL FOOD BUSINESSES WILL PROVIDE REAL-LIFE EXPERIENCE.CLIENTS WILL BE OFFERED INTERNSHIPS WITH FOOD BUSINESSES THAT UTILIZE THE FACILITY. WORKINGWITH OUR NEIGHBORHOOD DEVELOPMENT DIVISION THAT PROVIDES ASSISTANCE TO LOCAL RESTAURANTS,WE WILL ENGAGE THEM TO BE PART OF THE OF THE PORTAL FOR THOSE SEEKING JOBS IN THE INDUSTRY. WE EXPECT TO SERVE 100 CLIENTS.

ACHIEVING HIGH SENSITIVITY IN CAVITY OPTOMECHANICAL MAGNETOMETRY

USING GENETICS TO IDENTIFY NEW ENDOMETRIAL CANCER THERAPEUTICS

TARGETING CEP55 IN TRIPLE-NEGATIVE BREAST CANCER

TAS::57 3600::TAS "SENSOR SCHEDULING AND FUSION FOR CATALOG MAINTENANCE OF RESIDENT SPACE OBJECTS"

NATIONAL LEADERSHIP GRANTS

WOMEN'S BUSINESS OWNERSHIP ASSISTANCE - CARES ACT

COMPARATIVE SAFETY OF BUPRENORPHINE VS. METHADONE IN PREGNANCY

VA IS PROVIDING FUNDING TO ASSIST WITH THE COSTS TO PROVIDE LEGAL SERVICES TO ELIGIBLE VETERANS AND PARTICIPANTS

LIBRARIANS FOR THE 21ST CENTURY

TAS::57 3600::TAS 'QUANTUM MICROSCOPY: REACHING AND SURPASSING THE QUANTUM LIMITS TO BIOLOGICAL IMAGING'

NICOP - OPTIMIZING COGNITIVE PERFORMANCE BY MIMICKING SLOW-WAVE SLEEP IN THE AWAKE BRAIN.

IMPLEMENTATION

WOMEN S BUSINESS OWNERSHIP ASSISTANCE-RENEWAL

NEW TECHNOLOGY FOR EARLY DETECTION OF RESIDUUM TISSUE DAMAGES.

WEARABLE BIOSENSORS FOR REAL-TIME PHYSIOLOGICAL MONITORING

ENVIRONMENTAL EDUCATION INITIATIVES

THE QUEENS PUBLIC LIBRARY WILL PARTNER WITH MUSEUMS AND OTHER ORGANIZATIONS TO CELEBRATE AND DOCUMENT 50 YEARS OF HIP HOP AND ITS ROLE IN AMERICAN CULTURE. THROUGH ITS LANGSTON HUGHES COMMUNITY LIBRARY AND CULTURAL CENTER BRANCH, THE LIBRARY WILL COORDINATE THE PRESENTATION OF IN-PERSON AND STREAMING EDUCATIONAL HIP HOP PROGRAMMING AROUND THE COUNTRY; HOLD A TWO-DAY SUMMIT TO EXPLORE THE HISTORY OF HIP HOP; AND CREATE A DIGITAL ARCHIVE OF EACH INSTITUTION’S PROGRAMS, WHICH WILL SERVE AS LESSONS AND LEARNING TOOLS FOR EDUCATORS ON THE IMPACT THAT HIP HOP HAS HAD ON BLACK CULTURE AND AMERICAN LIFE.

THE QUEENS PUBLIC LIBRARY WILL PARTNER WITH QUEENS DEFENDERS, A PUBLIC DEFENDER ORGANIZATION, TO RECRUIT PAROLEE PARTICIPANTS AND PROVIDE THEM WITH THE INFORMATION, SKILLS, TECHNOLOGY, AND CONNECTIONS TO RESOURCES NEEDED TO REINTEGRATE SUCCESSFULLY AND AVOID RECIDIVISM. THE IMMEDIATE ACCESS TECHNOLOGY REENTRY PROGRAM WILL ADDRESS PAROLEES' UNIQUE TRANSITION FROM CORRECTIONAL FACILITY TO SOCIETY DURING A PANDEMIC. THIS PROGRAM WILL ASSIST 75 FORMERLY INCARCERATED INDIVIDUALS OVER A TWO-YEAR PERIOD. PARTICIPANTS WILL RECEIVE A SMART PHONE, GAIN THE EXPERIENCE AND SKILLS TO USE THEIR PHONES TO CONNECT, AND ACQUIRE DIGITAL SKILLS, KNOWLEDGE, AND RESOURCES.

MODELING AND CALIBRATING TRUSTED INTERACTIONS BETWEEN A HUMAN AGENT AND AI SYSTEM: A COMBINED QUANTUM-COGNITIVE AND EEG BASED APPROACH.

FAIR HOUSING ORGANIZATION INITIATIVES

FAIR HOUSING ORGANIZATION INITIATIVES

PRIVATE ENFORCEMENT INITIATIVES

THE QUEENS MUSEUM OF ART WILL CARRY OUT A CONSERVATION PROJECT FOR THE PANORAMA OF THE CITY OF NEW YORK, A LARGE-SCALE MODEL OF NEW YORK CITY THAT WAS BUILT FOR THE 1964-1965 NEW YORK WORLD’S FAIR.  THE MODEL WAS CREATED BY MORE THAN 100 ARTISANS, COVERS AN AREA OF 9,335 SQUARE FEET, AND CONTAINS 895,000 BUILDINGS. PROJECT ACTIVITIES WILL INCLUDE AN OVERALL ASSESSMENT OF THE MODEL’S 272 PANELS AS WELL AS REPAINTING AND REINFORCEMENT OF THE STRUCTURAL SUPPORT. CONSERVATORS WILL ALSO REPAIR THE LIGHTING SYSTEM WITHIN THE MODEL, WHICH CODES FOR DIFFERENT BUILDING FUNCTIONS. WHEN RESTORED, THE MODEL WILL BE A RESOURCE FOR HISTORIANS AND RESEARCHERS OF NEW YORK CITY HISTORY.

TAS::57 3600::TAS "LARGE-EDDY SIMULATION OF JETS WITH EMBEDDED VORTICES IMPINGING ON A FLAT SURFACE"

UNDERSTANDING THE EXTRACELLULAR VESICLE-MEDIATED MECHANISM (S) OF RESISTANCE IN ADVANCED PROSTATE CANCER

WBC - NY - QUEENS ECONOMIC DEVELOPMENT CORPORATION

WOMEN'S BUSINESS OWNERSHIP ASSISTANCE NEW RENEWAL

TAS::57 3600::TAS CLUSTER-STATE QUANTUM ERROR-CORRECTION BASED ON ADS/CFT

QUEEN'S TELEHEALTH NAVIGATOR TRAINING PROGRAM - HAWAII

CHARACTERIZATION AND VALIDATION OF A NEW MOUSE MODEL OF SPONTANEOUS ENDOMETRIOSIS TO IMPLEMENT TRANSLATION OF BASIC RESEARCH TO THE CLINIC

MICROBES THAT MATTER: DEFINING OPTIMAL FORMULATIONS FOR MICROBIAL ECOSYSTEM THERAPEUTICS

EPITHELIAL TISSUE MECHANICS: A NEW KEY TO RELAPSE IN CHRONIC INFLAMMATORY BOWEL DISEASE

PRECISION DIAGNOSTICS FOR EARLY MELANOMA DETECTION USING SPATIAL BIOLOGY AND AI-GUIDED IMAGE ANALYSIS

EARMARKS

ROLE OF STAT3 AND ERB2 IN BREAST CANCER

SINGLE MOLECULE BIOMOLECULAR CONDENSATE ANALYSIS IN NEURONS - PROJECT SUMMARY/ABSTRACT BIOMOLECULAR CONDENSATES (BMCS) DEFINE SMALL MEMBRANELESS CELLULAR COMPARTMENTS THAT SEGREGATE SPECIFIC PROTEINS AND NUCLEIC ACIDS TO GENERATE CELLULAR FUNCTIONS. FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING (FRAP) IS CURRENTLY THE METHOD OF CHOICE TO CHARACTERIZE BMCS IN VITRO AND IN VIVO AND DERIVE THE AVERAGE DIFFUSION AND TRAPPING OF MOLECULES TRAPPED IN THESE CONDENSATES. ALTHOUGH FRAP IS A GOOD WAY TO RETRIEVE THESE IMPORTANT METRICS, IT GREATLY LIMITS OUR UNDERSTANDING OF BMCS NANOSCALE ORGANIZATION AND DYNAMICS IN LIVE CELLS AND PRECLUDES THE ANALYSIS OF NANOSCALE BMCS (BELOW THE DIFFRACTION OF LIGHT ~200 NM). SINGLE-MOLECULE IMAGING SUPER-RESOLUTION MICROSCOPY ALLOWS DIRECT IMAGING OF MOLECULES TRAPPED IN BMCS WITH MUCH GREATER SPATIOTEMPORAL RESOLUTION BOTH IN VITRO AND IN LIVE NEURONS, AND HAS THE POTENTIAL TO REVEAL NANOSCALE BMCS AND THEIR EVOLUTION IN THE CONTEXT OF AGEING AND ALZHEIMER’S DISEASE (AD). HOWEVER, THERE ARE CURRENTLY NO BIOINFORMATIC TOOLS TO SPECIFICALLY ANALYZE BMCS AT THE SINGLE-MOLECULE LEVEL. WE HAVE DEVELOPED A NOVEL TOOL, NAMED NANOSCALE SPATIOTEMPORAL INDEXING CLUSTERING (NASTIC), (WALLIS ET AL., BIORXIV, 2021, REF. 7), WHICH OFFERS UNPRECEDENTED INSIGHTS INTO THE DYNAMICS OF PROTEINS UNDERGOING LIQUID-LIQUID PHASE SEPARATION/TRANSITION IN LARGE AND NANOSCALE BMCS, IN LIVE NEURONS. WE IDENTIFIED TAU AND SYNUCLEIN AS CANDIDATES FOR THEIR ABILITY TO GENERATE SYNAPTIC BMCS IN HIPPOCAMPAL NEURONS. NASTIC ANALYSIS REVEALS THAT TAU MOLECULES CAN INDEED FORM SMALL NANOCLUSTERS IN LIVE HIPPOCAMPAL NEURONS IN WHICH THEY EXHIBIT VERY LOW MOBILITY AND SENSITIVITY TO 1,6-HEXANEDIOL, AN ALIPHATIC ALCOHOL USED TO INHIBIT WEAK MOLECULAR INTERACTIONS THAT MEDIATE BMCS. NASTIC WILL BE AT THE CORE OF OUR ABILITY TO MAKE A SIGNIFICANT CONTRIBUTION TO THE UNDERSTANDING OF BMCS IN NEURONS BECAUSE IT OFFERS UNPRECEDENTED OPPORTUNITIES TO EXAMINE THE SPATIOTEMPORAL BEHAVIOUR OF MOLECULES IN THESE CONDENSATES. NASTIC WILL BE DEVELOPED FURTHER TO ENCOMPASS TWO-COLOR SINGLE-MOLECULE ANALYSIS. THIS WILL BE INSTRUMENTAL TO ASSESS THE SPATIOTEMPORAL RELATIONSHIP OF THESE NANOSCALE BMCS WITH THEIR CELLULAR ENVIRONMENT IN 2 AND 3D. WE WILL VALIDATE OUR TWO-COLOR NASTIC IMPLEMENTATION WITH THE PAIRWISE DUAL IMAGING OF TAU WILDTYPE AND AD MUTANT P301L, AND A-SYNUCLEIN. THIS WILL ALLOW US TO DECIPHER THE CO-CLUSTERING DYNAMICS AND EXAMINE POTENTIAL HIERARCHICAL DEPENDENCY OF ONE NANOBMC UPON THE OTHER ALLOWING REFINED UNDERSTANDING OF THE GENERATION OF NANOSCALE BMCS IN SYNAPSES. WE ANTICIPATE THAT THE P301L MUTATION WILL LARGELY INCREASE THE SIZE AND LIFETIME OF THE TAU NANOBMCS AND ALTER THEIR RELATIONSHIP WITH OTHER SYNAPTIC MOLECULES. THE OUTCOME OF THIS GRANT WILL BE THE DEVELOPMENT AND VALIDATION OF AN ANALYTICAL PIPELINE THAT WILL ENABLE EXPLORATION OF THE SPATIOTEMPORAL RELATIONSHIP OF TAU AND A-SYNUCLEIN NANOBMCS IN LIVE HIPPOCAMPAL NEURONS. OUR PROJECT WILL THEREFORE GENERATE DATA AND A MUCH-NEEDED TECHNOLOGY OPENING NEW AVENUES FOR OUR UNDERSTANDING OF BMCS IN NEURONAL FUNCTION AND AD.

EXPLORING THE EFFECT OF HUMAN BLOOD MICRORNAS ON MOSQUITO BIOLOGY

DISCOVERY OF POLYMYXIN-BASED ANTIBACTERIAL AGENTS ACTIVE AGAINST MULTI-DRUG RESIS

TAS::57 3600::TAS BASIC RESEARCH FOR AOARD PROPOSAL 16IOA026 "BIO-INSPIRED PERIPERSONAL SPACE SENSORS FOR SOCIAL INTERACTION"

PRIME ONE

THE SOUTH QUEENS BOYS & GIRLS CLUB AFTER-SCHOOL PROGRAM:THE PURPOSE OF THIS PROJECT IS TO PREVENT DANGEROUS BEHAVIORS, SPECIFICALLY GANG ACTIVITY, DR

TARGETING THE PLASTIC NATURE OF PROSTATE CANCER METASTASIS TO IMPROVE THERAPEUTIC STRATEGIES FOR ADVANCED DISEASE.

ALTERNATIVE THERAPIES FOR BENIGN PROSTATIC HYPERPLASIA

THE QUEENS MUSEUM (QM) WILL RESEARCH, DEVELOP, AND PILOT DESIGN SOLUTIONS FOR THEIR CENTRAL ATRIUM TO MAKE THIS CRITICAL SPACE OF THE MUSEUM MORE ACCESSIBLE FOR INDIVIDUALS OF ALL AGES, ABILITIES, AND LINGUISTIC PREFERENCES. IN EVALUATING ACCESSIBILITY FOR EVERY VISITOR, QM IDENTIFIED THAT THEIR CENTRAL ATRIUM REQUIRES PHYSICAL UPDATES. THE PROJECT, TITLED CENTRAL ATRIUM FOR ALL, WILL PROVIDE DESIGN RECOMMENDATIONS THAT ADDRESS THE ARTICULATED NEEDS OF THE MUSEUM?S COMMUNITY, ENSURING THAT ALL VISITORS CAN FULLY ENGAGE WITH THE DIVERSE ROSTER OF PROGRAMS AND RESOURCES. THIS PROJECT WILL ENSURE THAT THE MUSEUM IS A WELCOMING SPACE FOR LEARNING FOR ALL, AS WELL AS GUIDE QM IN THE DEVELOPMENT OF INCLUSIVE DESIGN RECOMMENDATIONS TO SHARE ACROSS THE FIELD.

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

SEE NOTICE OF AWARD, ATTACHMENT 1 - TERMS AND CONDITIONS, ATTACHMENT D, STATEMENT OF WORK, ABSTRACT.

QUEENS PUBLIC LIBRARY S INNOVATIVE CITIZENSHIP EDUCATION PROGRAM

FY 2013 CITIZENSHIP AND INTEGRATION DIRECT SERVICES GRANT PROGRAM: CITIZENSHIP INSTRUCTION AND NATURALIZATION APPLICATION SERVICES

USING A NOVEL HUMANIZED MOUSE MODEL TO INVESTIGATE HOW EBV INFECTION AT DIFFERENT AGES POTENTIATES DEVELOPMENT OF CNS DEMYELINATING DISEASE

THE QUEENS MEMORY PROJECT AT QUEENS PUBLIC LIBRARY WILL DEVELOP A COMPREHENSIVE RESOURCE GUIDE WITH CASE STUDIES DESIGNED TO EMPOWER PUBLIC LIBRARIES IN PRESERVING LOCAL HISTORY AND ENHANCE THEIR COMMUNITY ARCHIVING CAPABILITIES. ACTIVITIES INCLUDE LEVERAGING EXISTING COMMUNITY-DRIVEN ARCHIVING TOOLKITS AND OTHER PUBLISHED RESOURCES TO AUDIT QUEENS MEMORY’S DIVERSE ONGOING COLLABORATIONS WITH LOCAL COMMUNITY ARCHIVES PARTNERS TO FIND AREAS FOR EXPANSION AND IMPROVEMENT USING THE TECHNIQUES AND STRATEGIES PUT FORTH BY THE NATIONAL COMMUNITY OF BEST PRACTICE. BY GAINING PERSPECTIVE FROM OUTSIDE EXPERTISE, THE PROJECT WILL IMPROVE LOCAL PRACTICE IN QUEENS AND PROVIDE USEFUL EXAMPLES FOR CASE STUDIES TO BE PUBLISHED ALONG WITH A HELPFUL RESOURCE GUIDE FOR OTHERS ENGAGED, OR SEEKING TO ENGAGE, IN THIS WORK. IN ADDITION TO THE RESOURCE GUIDE AND CASE STUDIES, EXPECTED OUTCOMES INCLUDE IMPROVED COMMUNITY ENGAGEMENT AND ENHANCED DIGITAL ARCHIVING TOOLS. BENEFICIARIES INCLUDE PUBLIC LIBRARIANS, ARCHIVISTS, AND THEIR LOCAL COMMUNITY MEMBERS.

TAS::57 3600::TAS AOARD PROPOSAL 16IOA027 "AN INFINITELY SCALABLE LEARNING AND RECOGNITION NETWORK", DATED 29 FEB 2016

DESIGNER ARTIFICIAL CELLS: CUSTOMIZED CELL MEMBRANE-COATED POROUS NANOPARTICLES FOR TARGETING LETHAL CYTOKINE STORM

INVESTIGATION OF ABLATION PRODUCTS IN THE NEAR WAKE OF A HIGH-SPEED HYPERSONIC VEHICLE

TAS::57 3600::TAS AOARD PROPOSAL 17IOA016 'CONTEXTUAL MODELS OF INFORMATION FUSION', DATED 6 DEC 16 (THE GRANTEE'S TECHNICAL PROPOSAL) IS HEREBY INCO

CHARACTERISATION OF LONG LENGTHS OF COMMERCIAL HIGH TEMPERATURE SUPERCONDUCTING (HTS) TAPE AND WIRE

SYSTEMATIC IDENTIFICATION, VALIDATION, AND EVALUATION OF BREAST CANCER RISK GENES THROUGH FOLLOW UP OF GENOME WIDE ASSOCIATION STUDIES

3-EPI-25-OH-D3: ORIGINS & BIOLOGICAL IMPORTANCE

QUEENS MEMORY #STOPASIANHATE PODCAST [IN THIS MOMENT OF SOCIAL RECKONING, AS WE RECONSIDER THE HISTORY OF ASIANS IN AMERICA, QUEENS BOROUGH PUBLIC LIBRARY PROPOSES TO USE THE PRODUCTION OF A 10-EPISODE QUEENS MEMORY PODCAST SEASON TO DEEPEN EXISTING PARTNERSHIPS AND CREATE NEW RELATIONSHIPS WITH ASIAN AMERICAN SERVICE ORGANIZATIONS, ACTIVISTS, SCHOLARS AND COMMUNITY MEMBERS WHO WILL PLAY A STRONG EDITORIAL ROLE IN THE DEVELOPMENT OF THE PODCAST. THE PROJECT WILL DRAW EXISTING ORAL HISTORY COLLECTIONS OUT OF THE LIBRARY'S ARCHIVES AND INTO PROFESSIONALLY PRODUCED PODCAST EPISODES, WHICH WILL INCREASE AWARENESS AND USE OF THESE VALUABLE AND OFTEN UNDER-UTILIZED ARCHIVAL RESOURCES. IT WILL ALSO DEVELOP THE TALENT AND PROFESSIONAL CREDENTIALS OF THE ASIAN AMERICAN MEDIA PROFESSIONALS HIRED FOR THEIR PROFESSIONAL SKILLS AND OF MEMBERSHIP IN THE COMMUNITIES FEATURED IN THESE EPISODES.] [PURPOSE: THE CREATION OF A 10-EPISODE QUEENS MEMORY PODCAST SEASON. THESE PODCASTS WILL BE CREATED USING EXISTING ORAL HISTORIES IN THE QPL?S LIBRARY, AND EDITED BY ASIAN AMERICAN ACTIVISTS, SCHOLARS, AND COMMUNITY MEMBERS.   ACTIVITIES TO BE PERFORMED: THE HIRING OF 53 ASIAN AMERICAN MEDIA PROFESSIONALS TO AID IN THE CONCEPTUALIZATION, SOURCING, FACT CHECKING, AND PRODUCTION OF EACH EPISODE. MULTILINGUAL PRODUCERS WILL MAKE THE PODCAST ACCESSIBLE IN EIGHT DIFFERENT ASIAN LANGUAGES (MANDARIN, BENGALI, KOREAN, TAGALOG, HINDI, URDU, TIBETAN, AND NEPALI), ALL OF WHICH WILL BE EXPLORED DURING THE SEASON. NEW CONTENT WILL BE ADDED TO THE PODCASTS AND TO QPL?S COLLECTIONS VIA AID FROM LOCAL COMMUNITY MEMBERS AND ORGANIZATIONS. A ?BEHIND THE SCENES? LIVE STREAM WILL OCCUR DURING THE RELEASE OF THE PODCAST, FEATURING PANELISTS WHO CONTRIBUTED TO THE SPECIFIC EPISODE AND FURTHER RESOURCES ON THE LANGUAGE HIGHLIGHTED WITHIN THE EPISODE.  EXPECTED OUTCOMES: THE PUBLISHING OF LOCAL ASIAN AMERICAN HISTORY VIA AN ACCESSIBLE AUDIO MEDIUM.  INTENDED BENEFICIARIES: THE QUEENS ASIAN AMERICAN COMMUNITIES, AS WELL AS NON ASIAN LISTENERS AND LISTENERS FROM OUTSIDE OF NEW YORK CITY.  SUBRECIPIENT ACTIVITIES:  THIS PROJECT DOES NOT INTEND TO ISSUE ANY SUBAWARDS. ]

ESTIMATING POST-RELEASE MORTALITY IN ISTIOPHORID BILLFISH

IMAGAING THE LIVING ACTIVITY OF CELLS

QUEENS COMMUNITY HOUSE, QUEENS, NY FOR FAMILY SUPPORT COUNSELORS.

BASIC RESEARCH FOR AOARD PROPOSAL 22IOA049 "PROTECTING SUPERCONDUCTING QUBITS FROM QUASIPARTICLE GENERATED BY COSMIC RAYS", DATED 24 MAR 2022 (THE GRA

MOLECULAR TARGETS IN ENDOVASCULAR PROGENITORS TO INHIBIT LUNG AND SKIN FIBROSIS IN SCLERODERMA

PROMOTE THE INTEREST OF SMALL BUSINESS CONCERNS OWNED AND CONTROLLED BY WOMEN AND REMOVE BARRIERS TOACCESSING CAPITAL

EXPERIMENTAL VALIDATION OF THE MMT THERMOCHEMICAL NONEQUILIBRIUM AIR CHEMISTRY MODEL IN THE X2 FREE-PISTON DRIVEN EXPANSION TUBE

DESIGNING POLYMERS AS BROAD SPECTRUM ANTIVIRALS TO RAPIDLY FIGHT EMERGING VIRAL INFECTIONS

IDENTIFYING ANTIGEN-SPECIFIC T AND B CELLS IN SERONEGATIVE RHEUMATOID ARTHRITIS SYNOVIAL TISSUE: IMPLICATIONS FOR ANTIGEN-SPECIFIC IMMUNOTHERAPY

DEVELOPMENT OF HTS TAPE METRICS AND TOOLSETS TO MAXIMISE NAVAL APPLICATION PERFORMANCE AND RESILIENCE

TAS::57 3600::TAS AOARD PROPOSAL 16IOA057 "RAPIDLY EXPANDING NON EQUILIBRIUM HYPERSONIC FLOW", DATED 15 MAR 2016 (THE GRANTEE'S TECHNICAL PROPOSAL) I

EXPANSION OF CENTRAL QUEENS ACADEMY CHARTER SCHOOL II

BASIC RESEARCH FOR AOARD PROPOSAL 20IOA012 "SELF-LEARNING PROCESS MODELLING IN COMPOSITES MANUFACTURING", DATED 26 NOV 19 (THE GRANTEE'S TECHNICAL PRO