Trinity University

TRINITY UNIVERSITY CARES ACT FOR RELIEF OF INSTITUTIONAL EXPENSES DUE TO THE COVID 19 PANDEMIC

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND FOR TRINITY UNIVERSITY. FUNDS WILL BE MADE AVAILABLE TO STUDENTS IN ACCORDANCE WITH THE ATTACHED CERTIFICATE OF AGREEMENT.

TRINITY UNIVERSITY UPWARD BOUND

DEVELOPMENT OF IMMUNOLOGICAL REAGENTS FOR THE IDENTIFICATION OF NEW WORLD MONKEY BIOMARKERS - PROJECT SUMMARY MARMOSETS, SQUIRREL MONKEYS, AND OWL MONKEYS ARE NEW WORLD MONKEYS (NWM) STUDIED EXTENSIVELY IN A BROAD ARRAY OF RESEARCH AREAS, INCLUDING INFECTION, VISION, AUDITION, SOCIAL BEHAVIOR, COGNITION, NEURODEGENERATIVE DISEASES, REPRODUCTION, AND GENETIC MANIPULATION. ONE CRITICAL SHORTCOMING OF THE NWM ANIMAL MODELS IS THE LIMITED NUMBER OF IMMUNOLOGICAL REAGENTS THAT ARE CURRENTLY AVAILABLE DUE TO MORE THAN 33 MILLION OF YEARS OF EVOLUTIONARY DIVERGENCE. THIS SCARCITY OF RESEARCH TOOLS REDUCES THE TRANSLATIONAL VALUE OF THESE NONHUMAN PRIMATES. THE GOAL OF THIS R24 APPLICATION IS TO REMEDY THIS DEFICIENCY BY GENERATING ANTIBODIES AND VALIDATING IMMUNOLOGICAL ASSAYS THAT IDENTIFY IMPORTANT NWM BIOMARKERS OF INFLAMMATION AND METABOLISM, FOR WHICH THERE IS CURRENTLY LACK OF REAGENTS. INFLAMMATION IS A COMMON PROCESS INVOLVED IN AGING, OBESITY, AND PATHOLOGIES SUCH AS INFECTIOUS DISEASES, MULTIPLE SCLEROSIS, AND AGE-RELATED NEURODEGENERATIVE DISORDERS, ALL OF WHICH ARE BEING MODELED IN THESE SPECIES. THE NWM INFLAMMATORY BIOMARKERS TO BE PRODUCED INCLUDE C-REACTIVE PROTEIN (CRP), INTERLEUKIN-4 (IL-4), IL-6, IL-10, INTERFERON GAMMA-INDUCIBLE PROTEIN 10 (CXCL10, IP-10), GRANZYME B, AND THE SURFACE GLYCOPROTEIN CD69. GASTROINTESTINAL HORMONES TO BE PRODUCED, CRITICAL FOR VALIDATION OF STUDIES OF METABOLIC SYNDROME, INCLUDE INSULIN, ADIPONECTIN, AND LEPTIN. IN ORDER TO ACCOMPLISH OUR GOAL, WE HAVE ASSEMBLED A TEAM OF SCIENTISTS FROM ACADEMIC AND RESEARCH INSTITUTIONS AND A BIOTECHNOLOGY COMPANY SPECIALIZED IN THE PRODUCTION OF REAGENTS OF VETERINARY AND HUMAN USE. WE WILL PRODUCE NWM PROTEINS IN EUKARYOTIC CELLS, AND USE THE RECOMBINANT MARMOSET PROTEINS TO PRODUCE MONOCLONAL ANTIBODIES (MMABS) IN MICE (SPECIFIC AIM 1). WE WILL THEN USE THE MARMOSET RECOMBINANT PROTEINS TO IDENTIFY EPITOPE SPECIFICITY OF THESE MABS, SELECT THE ONES THAT ALSO RECOGNIZE SQUIRREL MONKEY AND OWL MONKEY HOMOLOGUES, AND IDENTIFY OPTIMAL ANTIBODY PAIRS FOR TECHNIQUES SUCH AS ELISA, ELISPOT, LUMINEX, AND INTRACELLULAR CYTOKINE STAINING (ICS) ASSAYS (SA 2). FINALLY, THESE IMMUNOLOGICAL ASSAYS WILL BE VALIDATED WITH SAMPLES OBTAINED FROM PLASMA ALIQUOTS FROM NWM EXPOSED TO TRANSIENT METABOLIC AND INFLAMMATORY CHALLENGES, AND FROM EX VIVO STIMULATED NWM CELLS (SA 3). AT THE END OF THIS PROJECT, RESEARCHERS WORKING IN DIFFERENT NWM MODELS OF HUMAN DISEASE WILL HAVE ACCESS TO RESEARCH TOOLS FOR IMPROVED VALIDATION OF THEIR PRECLINICAL MODELS. A RESOURCE WEBSITE WILL BE DEVELOPED TO DISSEMINATE THE AVAILABILITY OF REAGENTS, TO TRACK THE IMPACT OF THESE REAGENTS IN BIOMEDICAL STUDIES, AND TO DISTRIBUTE PROTOCOLS AND SOPS. DEVELOPMENT OF THESE REAGENTS IS OF TRANS-NIH INTEREST, WILL INCREASE THE TRANSLATIONAL VALUE OF MARMOSET, SQUIRREL MONKEY AND OWL MONKEY MODLES, AND WILL EXPAND THE SCIENTIFIC DATA OBTAINED FROM THESE ANIMALS.

UPWARD BOUND

EXPANDING EDUCATIONAL OPPORTUNITY THROUGH COLLABORATIVE COMMUNITY-BASED PARTNERSHIP

NOYCE TEACHING FELLOWS AT TRINITY UNIVERSITY

UPWARD BOUND PROGRAM

MARMOSETS AS A MODEL FOR UNDERSTANDING SOCIAL, NEUROENDOCRINE, AND VASCULAR CONTRIBUTIONS TO COGNITIVE AGING

TRINITY UNIVERSITY MCNAIR SCHOLARS PROGRAM

MCNAIR SCHOLARS PROGRAM AT TRINITY UNIVERSITY

RONALD E. MCNAIR POSTBACCALAUREATE ACHIEVEMENT

RONALD E. MCNAIR POST-BACCALAUREATE ACHIEVEMENT

UBM INSTITUTIONAL: INTEGRATED RESEARCH IN BIOMATHEMATICS AT TRINITY UNIVERSITY

LIPID PHOSPHATASES AS DYNAMIC REGULATORS OF PROTEIN CONFORMATION

MRI: ACQUISITION OF HIGH PERFORMANCE SCIENTIFIC COMPUTING CLUSTER AT TRINITY UNIVERSITY

FINANCIAL AID FOR SCIENCE AND TECHNOLOGY STUDENTS ENHANCED WITH RESEARCH

FINANCIAL AID FOR SCIENCE AND TECHNOLOGY STUDENTS

ROBERT NOYCE SCHOLARSHIPS AT TRINITY UNIVERSITY

CAREER: SYNTHETIC CO-HOSTS FOR SEQUENCE-SPECIFIC RECOGNITION AND LABELING OF PEPTIDES IN AQUEOUS SOLUTION

COLLABORATIVE RESEARCH: RUI: STRUCTURE-FUNCTION RELATIONSHIPS AND EFFICIENCY OF BACTERIAL FLAGELLAR MOTORS USING COMPUTATIONAL FLUID DYNAMICS AND DIRECTED EVOLUTION EXPERIMENTS -BACTERIA ARE AMONG THE OLDEST ORGANISMS ON EARTH. THROUGH BIOLOGICAL EVOLUTION, MANY BACTERIA HAVE ACQUIRED A BIOMECHANICAL FLAGELLUM CONSISTING OF A HELICAL APPENDAGE THAT IS ROTATED BY A MOLECULAR MOTOR TO MOVE THEM THROUGH THEIR FLUID ENVIRONMENT. FLAGELLAR GENETIC ORGANIZATION, REGULATION, AND STRUCTURE ARE BROADLY CONSERVED ACROSS BACTERIAL SPECIES, AND FLAGELLA PLAY VITAL ROLES IN THE BACTERIAL LIFE CYCLE, INCLUDING IN HOST-MICROBE INTERACTIONS. THUS, UNDERSTANDING BACTERIAL MOTILITY HAS BROAD IMPLICATIONS IN MEDICINE, IN BIOLOGY, AND IN THE DEVELOPMENT OF MICRO-ROBOTIC SWIMMERS. THIS RESEARCH AIMS TO UNDERSTAND HOW THE ENERGY EFFICIENCY OF THE BACTERIAL MOTOR HAS INFLUENCED THE EVOLUTIONARY DEVELOPMENT OF THE BACTERIAL MOTILITY SYSTEM. THE PROJECT WILL CREATE PRECISELY CALIBRATED COMPUTATIONAL TOOLS TO STUDY VARIANTS OF THE MEDICALLY IMPORTANT ORGANISM PSEUDOMONAS AERUGINOSA WITH DIFFERENT MOTOR PROPERTIES. THE ENERGY EFFICIENCY OF EACH VARIANT WILL BE MEASURED AND ASSOCIATED WITH STRUCTURAL CHANGES IN MOTOR COMPONENTS. THE COMPUTATIONAL TOOLS AND A LIBRARY OF THESE MOTOR VARIANTS WILL BE MADE PUBLICLY AVAILABLE SO THAT OTHER RESEARCHERS MAY USE THEM FOR RELATED RESEARCH. THE EXPERIMENTS AND COMPUTATIONS REQUIRED FOR THIS WORK WILL ALL BE CONDUCTED IN TANDEM WITH UNDERGRADUATE STUDENTS, WITH THE GOAL THAT MANY OF THEM, INCLUDING STUDENTS FROM UNDERREPRESENTED BACKGROUNDS, WILL PURSUE CAREERS IN INTERDISCIPLINARY SCIENTIFIC RESEARCH. RECENT WORK HAS UNCOVERED THE MOLECULAR STRUCTURE OF THE STATOR UNIT RESPONSIBLE FOR GENERATING TORQUE IN THE BACTERIAL FLAGELLAR MOTOR. THIS PROJECT AIMS TO CHARACTERIZE THE RELATIONSHIPS BETWEEN SPECIFIC STRUCTURAL PROPERTIES OF THE BACTERIAL STATOR AND ITS ENERGY EFFICIENCY. STRAINS OF P. AERUGINOSA WITH SUBOPTIMAL STATORS WILL BE CREATED AND USED IN DIRECTED EVOLUTION EXPERIMENTS TO SELECT FOR VARIANT STRAINS WITH IMPROVED MOTILITY. QUANTITATIVE MICROSCOPY WILL BE USED TO MEASURE BACTERIAL MOTION AS THEY MOVE THROUGH DIFFERENT FLUID ENVIRONMENTS. EXPERIMENTALLY DETERMINED TRAJECTORIES WILL BE INPUT INTO PRECISELY CALIBRATED COMPUTATIONAL FLUID DYNAMICS SIMULATIONS TO DETERMINE THE ENERGY EFFICIENCY OF THE STATOR. THE DETERMINATION OF SEQUENCE AND STRUCTURAL FEATURES OF EVOLVED STATORS WITH DIFFERENT ENERGY EFFICIENCIES WILL PROVIDE INSIGHTS INTO THE RELATIONSHIP BETWEEN THE MECHANICAL PROPERTIES AND BIOMOLECULAR STRUCTURES OF NANOMOTORS. ADDITIONALLY, TO STUDY HOW THE PRESENCE OF A NEARBY BOUNDARY AFFECTS THE SWIMMING EFFICIENCY OF THE EVOLVED STRAINS, MOTILITY EXPERIMENTS WILL BE PERFORMED NEAR SMOOTH SURFACES AND SURFACES WITH TUNABLE VISCOSITY AND ELECTROSTATIC PROPERTIES. THE SURFACES WILL BE CONSTRUCTED FROM LIPIDS AND PROTEINS TO MIMIC THE ENVIRONMENTS THAT P. AERUGINOSA COMMONLY ENCOUNTERS IN ITS NATURAL ENVIRONMENT AS IT UNDERGOES MOTILE-TO-SESSILE TRANSITIONS. THE CALIBRATION MEASUREMENTS WILL ALLOW OTHER RESEARCHERS TO CREATE ADDITIONAL PRECISELY CALIBRATED COMPUTATIONAL FLUID DYNAMICS MODELS AND DEVELOP SIMILAR COMPUTATIONAL PROBES AS USED IN THIS PROJECT. THE PUBLICLY AVAILABLE LIBRARY OF EVOLVED MOTOR VARIANTS AND THE STRUCTURE-FUNCTION MAP FOR THE STATOR WILL DEEPEN THE UNDERSTANDING OF THE RELATIONSHIP BETWEEN MOTOR PROTEINS AND MOTOR PERFORMANCE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

FUNCTIONALIZED RECEPTORS FOR EFFICIENT EPITOPE RECOGNITION - PROJECT SUMMARY BIOMEDICAL SCIENCE RELIES HEAVILY ON METHODS FOR ATTACHING LIGAND BINDING SITES TO PROTEINS. SUCH EPITOPE TAGS ARE IMPORTANT FOR PROTEIN AFFINITY PURIFICATION, FOR IMPROVING PROTEIN SOLUBILITY, AND FOR ADDING FUNCTIONALITY TO PROTEINS SUCH AS FLUORESCENT LABELS OR SITES FOR CHEMICAL MODIFICATION. THE PROPOSED RESEARCH AIMS TO DEVELOP SYNTHETIC RECEPTORS THAT TARGET PROTEINS ENGINEERED WITH EFFICIENT EPITOPES COMPRISING ONLY 2-3 AMINO ACID RESIDUES. THE EPITOPES ARE BOUND SITE-SELECTIVELY AND WITH SUBNANOMOLAR AFFINITY BY SMALL (1-2 KDA) MONOFUNCTIONAL SYNTHETIC RECEPTORS WITH ADDED ABILITY TO BIND, FLUORESCE, OR ATTACH TO SOLID SUPPORTS. THE RECEPTORS ARE STABLE AND FUNCTIONAL IN PHYSIOLOGICAL CONDITIONS, INCLUDING SERUM, AND PROTEINS BOUND TO THESE RECEPTORS CAN BE RELEASED ON DEMAND UPON THE ADDITION OF SMALL MOLECULE COMPETITORS. THE PROPOSED AIMS WILL: 1) FURTHER OPTIMIZE THE EPITOPES; 2) INSTALL THE EPITOPES INTO RECOMBINANT PROTEINS AND HUMAN INSULIN; AND 3) DEVELOP MONOFUNCTIONAL DERIVATIVES OF THE SYNTHETIC RECEPTOR TO ENHANCE BINDING AND TO ENABLE AFFINITY PURIFICATION AND PROTEIN SENSING. THE PROPOSED EPITOPES WILL ADD FUNCTION TO TARGET PROTEINS WHILE HAVING MINIMAL IMPACT ON STRUCTURE AND ACTIVITY. THE PROPOSED WORK BUILDS ON THE RULES FOR SEQUENCE-SELECTIVE RECOGNITION OF PEPTIDES AND PROTEINS BY CUCURBIT[N]URILS ESTABLISHED IN THE UNDERGRADUATE RESEARCH LAB OF THE PI. MANY RESEARCH GROUPS HAVE DEVELOPED APPLICATIONS BUILT ON THESE RULES, AND WE ANTICIPATE THAT THE PROPOSED RESEARCH WILL ESTABLISH A CORE COMPETENCY THAT SHOULD FACILITATE EXISTING BIOMEDICAL APPLICATIONS AND INSPIRE NEW ONES.

RUI: BEHAVIORAL CONVERGENCE IN CARIBBEAN LIZARDS: MORPHOLOGICAL AND PHYSIOLOGICAL MECHANISMS

MINIMAL PROTEIN AFFINITY TAGS - PROJECT SUMMARY BIOMEDICAL SCIENCE RELIES HEAVILY ON METHODS FOR ATTACHING LIGAND BINDING SITES TO PROTEINS. SUCH AFFINITY TAGS ARE ESSENTIAL FOR PROTEIN AFFINITY PURIFICATION, FOR IMPROVING PROTEIN SOLUBILITY, AND FOR ADDING FUNCTIONALITY TO PROTEINS SUCH AS FLUORESCENT LABELS OR SITES FOR CHEMICAL MODIFICATION. THE PROPOSED RESEARCH AIMS TO DEVELOP A GENERAL METHOD FOR MODIFYING TARGET PROTEINS USING AFFINITY TAGS THAT COMPRISE ONLY 1-2 AMINO ACID RESIDUES. THE MINIMAL AFFINITY TAGS ARE BOUND SITE-SPECIFICALLY AND WITH HIGH-AFFINITY BY SMALL (1-2 KDA) SYNTHETIC RECEPTOR THAT CAN BE CONJUGATED TO SOLID SUPPORTS AND SMALL MOLECULES. THE RECEPTORS ARE STABLE AND FUNCTIONAL IN PHYSIOLOGIC CONDITIONS, INCLUDING SERUM, AND PROTEINS BOUND TO THESE RECEPTORS CAN BE RELEASED EASILY UPON THE ADDITION OF SMALL MOLECULE COMPETITORS. THE PROPOSED AIMS INCLUDE: 1) FURTHER OPTIMIZING DIPEPTIDE RECOGNITION SITES; 2) INVESTIGATING THE BINDING OF SYNTHETIC RECEPTORS TO TARGET SITES THAT ALREADY EXIST IN PROTEIN PHARMACEUTICALS AND OTHER BIOACTIVE PEPTIDES AND PROTEINS; 3) INSTALLING MINIMAL AFFINITY TAGS INTO RECOMBINANT PROTEINS AND PROTEIN PHARMACEUTICALS; AND 4) DEVELOPING FUNCTIONAL DERIVATIVES OF THE SYNTHETIC RECEPTOR TO BRING FUNCTIONALITY TO THE TARGET PROTEINS. SUCH MINIMAL AFFINITY TAGS WILL ADD SUBSTANTIAL FUNCTION TO TARGET PROTEINS WHILE HAVING MINIMAL IMPACT ON THEIR STRUCTURE AND ACTIVITY. THE PROPOSED WORK BUILDS ON THE RULES FOR SELECTIVE, HIGH-AFFINITY RECOGNITION OF PEPTIDES AND PROTEINS BY CUCURBIT[N]URILS ESTABLISHED IN THE UNDERGRADUATE RESEARCH LAB OF THE PI. MANY RESEARCH GROUPS HAVE DEVELOPED APPLICATIONS BUILT ON THESE RULES, AND WE ANTICIPATE THAT THE PROPOSED RESEARCH WILL ESTABLISH A CORE COMPETENCY THAT SHOULD FACILITATE EXISTING BIOMEDICAL APPLICATIONS AND INSPIRE NEW ONES.

MRI-R2: ACQUISITION OF A 500 MHZ NMR SPECTROMETER BY TRINITY UNIVERSITY

METALLOPEPTIDE BASED MIMICS OF MONONUCLEAR NONHEME IRON ENZYMES: UNDERSTANDING ENZYMATIC REACTIVITY USING DESIGNED METALLOPEPTIDES - PROJECT ABSTRACT. MONONUCLEAR NONHEME IRON (MNHFE) ENZYMES PERFORM AN ARRAY OF CHEMICALLY DIVERSE REACTIONS THAT ARE VITAL TO MANY DIFFERENT ASPECTS OF HUMAN HEALTH INCLUDING: ANTIBIOTIC BIOSYNTHESIS, PRODUCTION OF KEY METABOLITES, AND DNA REPAIR. THUS, THE MISREGULATION AND DYSFUNCTION OF MNHFE ENZYMES HAVE BEEN IMPLICATED IN A NUMBER OF DISORDERS INCLUDING NEURODEGENERATION, CANCERS, DIABETES, AND CARDIOVASCULAR DISEASES. A LARGE CLASS OF MNHFE ENZYMES CONTAINS A REDUCED FE(II) ION THAT ACTIVATES DIOXYGEN, FORMING A HIGHLY REACTIVE FEIII-O2– SPECIES. ONCE FORMED, THIS FEIII-O2– INTERMEDIATE CAN PROMOTE A LARGE NUMBER OF DIFFERENT REACTIONS LEADING TO AN ENORMOUS DIVERSITY IN CHEMICAL REACTIVITY. DESPITE THE SURPRISING SIMILARITIES IN ACTIVE-SITE (AND SOMETIMES SUBSTRATE) STRUCTURES, EACH ENZYME PROMOTES A HIGHLY SPECIFIC REACTION AND YIELDS A HIGHLY SPECIFIC PRODUCT. THE FACTORS LEADING TO SUCH HIGH REACTION SPECIFICITY FROM THESE SIMILAR ACTIVE-SITE STRUCTURES ARE NOT FULLY UNDERSTOOD. THE OVERARCHING GOAL OF THE WORK PROPOSED HEREIN IS TO UNDERSTAND HOW THE FEIII-O2– INTERMEDIATE IN TWO MNHFE ENZYMES, CYSTEINE DIOXYGENASE (CDO) AND ISOPENICILLIN-N-SYNTHASE (IPNS), CAN SELECTIVELY PROMOTE TWO VASTLY DIFFERENT REACTIONS ON STRUCTURALLY SIMILAR SUBSTRATES: SULFUR OXYGENATION (CDO) VS C-H ATOM ABSTRACTION (IPNS). BOTH CDO AND IPNS MODIFY A THIOL-CONTAINING SUBSTRATE ONCE IT IS COORDINATED TO THE IRON-CENTER. WE HYPOTHESIZE THAT THE DIFFERENTIAL REACTIVITY IN THESE TWO ENZYMES IS PROMOTED BY THE ORIENTATION OF THE NOMINAL S(3P)-TYPE ORBITAL OF THE COORDINATED SUBSTRATE, WHICH WILL TURN ON OR OFF A THERMODYNAMICALLY FAVORED S-BASED OXYGENATION REACTION. TO EXPLORE THIS HYPOTHESIS, WE WILL PREPARE A LIBRARY OF STRUCTURALLY RELATED METALLOPEPTIDES THAT WILL PROMOTE EITHER CDO- OR IPNS-LIKE CHEMISTRIES. THE MAJOR DIFFERENCE BETWEEN THESE PEPTIDES WILL BE THE ORIENTATION OF THE S(3P)-TYPE ORBITAL RELATIVE TO THE VECTOR OF ATTACK OF THE SUPEROXO LIGAND OF THE FEIII-O2– INTERMEDIATE. BECAUSE THE GEOMETRIC AND ELECTRONIC STRUCTURES OF THESE PEPTIDES WILL ALL BE NEARLY IDENTICAL, ALL DIFFERENCES IN REACTIVITY WILL BE ATTRIBUTABLE TO THE S(3P) ORBITAL ORIENTATION. THIS RESEARCH MAKES USE OF A LARGE NUMBER OF TOOLS ENCOUNTERED IN BIOINORGANIC CHEMISTRY, THUS PROVIDING AN EXCELLENT TRAINING PLATFORM FOR UNDERGRADUATE RESEARCHERS. IN ADDITION TO BIOMIMIETIC METALLOPEPTIDE DESIGN AND SYNTHESIS, THESE SYSTEMS WILL BE SUBJECTED TO MECHANISTIC, SPECTROSCOPIC (ELECTRONIC ABSORPTION, EPR, (M)CD, X-RAY ABSORPTION, VIBRATIONAL AND MÖSSBAUER SPECTROSCOPIES), AND HIGH-LEVEL COMPUTATIONAL STUDIES. THE USE OF METALLOENZYME MIMICS IN OUR INVESTIGATIONS IS ESPECIALLY NOTEWORTHY; FEW STUDIES HAVE BEEN PERFORMED WHERE INSIGHT INTO SPECIFIC BIOCHEMICAL PROCESSES ARE REVEALED THROUGH METALLOPEPTIDE BASED METALLOENZYME MIMICS. THEREFORE, COMPLETION OF THIS PROJECT WILL NOT ONLY REVEAL INTERESTING ASPECTS OF MNHFE BIOCHEMISTRY, BUT WILL ALSO EXPAND THE LIMITS OF INVESTIGATIONS CONCERNING METALLOPEPTIDE BASED METALLOENZYME MIMICS.

MACROSTRUCTURAL AND MICROSTRUCTURAL ANALYSIS OF THE PRIMATE CORPUS CALLOSUM

MRI: ACQUISITION OF CONFOCAL MICROSCOPY SYSTEM FOR DYNAMIC IMAGING AND ANALYSIS IN RESEARCH AND LEARNING AT TRINITY UNIVERSITY

THE INFLUENCE OF CYSTEINATE PROTONATION IN NICKEL CONTAINING METALLOENZYMES

CAREER: FLUOROGENIC RADICAL POLYMERIZATION FOR SIGNAL AMPLIFICATION AND DETECTION

CAREER: TESTING MODELS OF CRETACEOUS CORDILLERAN PALEOGEOGRAPHY: AN INTEGRATED PROVENANCE STUDY OF FOUR BASINS

IDENTIFICATION OF A NOVEL REGULATORY ELEMENT IN THE ASSEMBLY OF THE SPLICEOSOME

SUPRAMOLECULAR STRATEGIES FOR THE CONTROLLED RELEASE OF PROTEIN DRUGS

BRANCHING PROCESS MODELS IN CELLULAR POPULATION DYNAMICS

RUI- UNDERSTANDING THE PH-DEPENDENT REDUCTION POTENTIAL OF THE RIESKE PROTEIN FROM THERMUS THERMOPHILUS USING SITE-DIRECTED MUTAGENESIS AND CHEMICAL

INTERGOVERNMENTAL MOBILITY ASSIGNMENT

PROBING THE POTENTIAL ROLE OF THE RIESKE PROTEIN IN SUPEROXIDE FORMATION IN COMPLEX III - ABSTRACT REACTIVE OXYGEN SPECIES INCLUDE MOLECULES SUCH AS SUPEROXIDE, PEROXIDE AND HYDROXYL RADICALS. HIGH LEVELS OF THESE MOLECULES HAVE BEEN SHOWN TO LEAD TO DISEASES SUCH AS HEART DISEASE, CANCER, AND NEURODEGENERATIVE DISEASES. THE PROPOSAL AIMS TO DETERMINE IF THE REDUCTION POTENTIAL OF THE RIESKE PROTEIN IN COMPLEX III CAN BE A SOURCE OF SUPEROXIDE WHEN THE REDUCTION POTENTIAL IS NOT MATCHED ITS REDOX PARTNER. IN ORDER TO STUDY THIS HYPOTHESIS, A YEAST SYSTEM WHERE MUTATIONS CAN BE MADE TO RIESKE HAS BEEN PRODUCED, AND A SERIES OF MUTANT YEAST STRAINS HAVE BEEN MADE. THE PRODUCTION OF SUPEROXIDE WILL BE MEASURED USING CONFOCAL MICROSCOPY AND ITS EFFECT ON THE YEAST ASCERTAINED THROUGH GROWTH ASSAYS. IN ADDITION, THE REDUCTION POTENTIAL OF THE ISOLATED YEAST RIESKE PROTEIN WILL BE MEASURED. THE PROTEIN WILL ALSO BE THOROUGHLY CHARACTERIZED, ADDING A NEW SYSTEM THAT HAS NOT BEEN EXPLORED PREVIOUSLY TO THE LITERATURE.

OXYTOCIN INDUCES RETROGRADE METAPLASTICITY TO ATTENUATE COCAINEPREFERENCE BEHAVIOR - PROJECT SUMMARY/ABSTRACT A GROWING NUMBER OF STUDIES HAVE DEMONSTRATED THAT OXYTOCIN (OXT) PROVIDES AN ATTENUATING EFFECT ON COCAINE REWARD BEHAVIORS IN RODENTS AND THEREFORE MAY BE INVESTIGATED AS A POTENTIAL MODULATOR OF COCAINE REWARD PROCESSES. DESPITE THIS, THE SPECIFIC MECHANISM THROUGH WHICH OXT EXERTS THIS MODULATORY EFFECT ON COCAINE- RELATED BEHAVIORS REMAINS UNCLEAR. THE PRESENT RESEARCH PROJECT PROPOSES THAT OXT ATTENUATES COCAINE- ASSOCIATED PREFERENCE VIA A TWO-FOLD MECHANISM ON DOPAMINE (DA) NEURONS WITHIN THE VENTRAL TEGMENTAL AREA (VTA). RECENT EVIDENCE SUGGESTS THAT OXT RECEPTORS (OXTRS) ON VTA DA NEURONS BOTH INCREASE TONIC FIRING OF THE DA NEURON AND DECREASES EXCITATORY INPUTS, LIKELY AFFECTING PHASIC ACTIVATION OF THE DA NEURON. THIS DECREASE IN EXCITATORY INPUTS HAS BEEN SHOWN TO BE MEDIATED BY AN OXT INTERACTION WITH PRESYNAPTIC CB1 RECEPTORS (CB1RS) ON GLUTAMATERGIC TERMINALS. THIS PROJECT INVESTIGATES THE FUNCTIONAL RELEVANCE OF THIS EFFECT USING A NOVEL COMBINATION OF TRANSGENIC RAT AND VIRALLY-DELIVERED SHRNA TO SILENCE VTA DA OXTRS OR PRESYNAPTIC GLUTAMATERGIC CB1RS. FIRST, OXTRS ON DA VTA NEURONS WILL BE SILENCED IN MALE AND FEMALE RATS USING A TRANSGENIC CRE RAT AND CRE-DEPENDENT KNOCKDOWN OF OXTRS TO DETERMINE THE EFFECT OF OXT-MEDIATED DA FIRING RATE. BEHAVIORALLY, OXT ATTENUATES COCAINE PREFERENCE BEHAVIORS, AND IT IS EXPECTED THAT SILENCING OF OXTRS ON VTA DA NEURONS WILL DIMINISH THIS EFFECT. SECOND, TO FURTHER ELUCIDATE THE SPECIFIC MECHANISM THROUGH WHICH OXT ATTENUATES COCAINE PREFERENCE VIA VTA DA NEURONS, CB1RS ON VTA GLUTAMATERGIC INPUTS WILL BE SILENCED USING A COMBINATION OF TRANSGENIC CRE RAT AND SHRNA SILENCING OF CB1R IN THE ABSENCE OF CRE EXPRESSION. OXT IS KNOWN TO REDUCE NEURONAL EXCITATION THROUGH PRODUCTION OF ENDOCANNABINIOIDS (ECB) THAT RETROGRADELY REDUCE PRESYNAPTIC INPUT VIA CB1 RECEPTORS. THROUGH THIS, THE EFFECT OF GLUTAMATERGIC CB1R SILENCING WILL BE ASSESSED ON OXT-MEDIATED VTA DA PHASIC NEURONAL FIRING. BEHAVIORALLY, THIS DEMONSTRATES THAT OXT-MEDIATED REDUCTION OF VTA DA PHASIC FIRING UNDERLIES OXT-MEDIATED ATTENUATION OF COCAINE-ASSOCIATED PREFERENCE. OVERALL, THIS PROJECT WILL UTILIZE A NOVEL COMBINATION OF TOOLS TO INVESTIGATE THE SPECIFIC NEURAL MECHANISM THROUGH WHICH OXT ATTENUATES COCAINE REWARD AND OFFER INSIGHT INTO THE USE OF OXT AS A THERAPEUTIC TARGET FOR COCAINE-RELATED DISORDERS IN MALES AND FEMALES.

RUI: PREPARATION AND KINETIC CHARACTERIZATION OF NEW BIMETALLIC AU-M SELECTIVE HYDROGENATION CATALYSTS

RUI: QUANTIFYING ELECTRON DONATION IN METAL-SUPPORT INTERACTIONS UTILIZING CO ADSORPTION STUDIES AND HAMMET RELATIONSHIPS FOR CATALYZED ORGANIC TRAN

STRUCTURAL AND FUNCTIONAL BRAIN CHANGES ASSOCIATED WITH MOTOR LEARNING

RUI: FUNDAMENTAL STUDIES ON THE SEPARATION MECHANISMS OF POROUS POLYMER MONOLITHS

RUI: TARGETING THE TERMINUS FOR SITE-SPECIFIC RECOGNITION AND LABELING OF PROTEINS

RUI: PREPARATION AND CHARACTERIZATION OF NEW HETEROGENEOUS BIMETALLIC AU-M CATALYSTS FOR SELECTIVE OXIDATIONS AND HYDROGENATIONS

INFLUENCE OF CYSTEINATE PROTONATION ON BIOLOGICALLY RELEVANT NICKEL-MEDIATED REACTIONS

COLLABORATIVE RESEARCH: EXTENDED FAMILY SUPPORT AND THE HOUSING STABILITY OF YOUTH -FAMILY REJECTION IS A WELL-KNOWN CAUSE OF YOUTH HOMELESSNESS. THIS PROJECT AIMS TO UNDERSTAND HOW SUPPORT FROM EXTENDED FAMILY MEMBERS SHAPES PATHWAYS OF HOUSING STABILITY AND SAFETY BEFORE YOUTH END UP AT SHELTERS OR ON THE STREETS. THE STUDY DOCUMENTS THE ROLES AND PRACTICES OF GRANDPARENTS, AUNTS, UNCLES, COUSINS, AND ADULT SIBLINGS IN PROVIDING LONG-TERM SHELTER AND HOUSING STABILITY FOR YOUTH WHOSE PARENTS ARE UNSUPPORTIVE OR AMBIVALENT ABOUT THEIR CHILDREN?S IDENTITIES AND BEHAVIORS. THE RESEARCH IS INNOVATIVE IN ITS FOCUS ON YOUTH WHO ARE EXPERIENCING CHALLENGES AT HOME BUT ARE NOT YET HOMELESS. THE STUDY ADVANCES THE SCIENCE ON FAMILIAL SOCIAL SUPPORT AND HOMELESSNESS. RESEARCHERS DRAW FROM THE STUDY?S FINDINGS TO ENGAGE IN OUTREACH TO YOUTH SHELTERS AND PROGRAMS AND INFORM PRACTITIONERS AND DECISION-MAKERS ON STRATEGIES TO PREVENT YOUTH HOMELESSNESS. TO UNDERSTAND THE ROLE OF NON-PARENTAL RELATIVES AND HOW THEIR SUPPORT SHAPES THE HOUSING STABILITY AND SAFETY OF YOUTH, THIS PROJECT STUDIES 80 YOUTH AGED 16-19 WHO ARE AT RISK OF HOMELESSNESS USING A 14-MONTH MIXED-METHODS LONGITUDINAL APPROACH. PARTICIPANTS ARE RECRUITED FROM TWO STATES IN THE SOUTHWEST UNITED STATES, INCLUDING YOUTH IN RURAL COMMUNITIES AND FROM MINORITY GROUPS. DATA ARE COLLECTED THROUGH AN INITIAL INTERVIEW, 10 MONTHLY SURVEYS, AND A FOLLOW-UP INTERVIEW TAILORED TO EACH RESPONDENT. RESEARCHERS EVALUATE HOW THE FORMS AND CONSISTENCY OF INSTRUMENTAL AND EMOTIONAL SUPPORT THAT YOUTHS RECEIVE FROM EXTENDED FAMILY INFLUENCE THEIR SENSE OF SAFETY AND HOUSING STABILITY. A LONGITUDINAL APPROACH ENABLES ANALYSIS OF HOW FAMILY SUPPORT AND HOUSING STABILITY AND SAFETY SHIFT OVER TIME. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS PROJECT FOCUSES ON THE CONNECTION BETWEEN HISTORICAL DISCRIMINATORY POLICIES AND PRESENT-DAY PERSISTENT RURAL POVERTY. UNDERSTANDING THIS CONNECTION IS FOUNDATIONAL TO CRAFTING EFFECTIVE PRESENT-DAY RURAL ECONOMIC DEVELOPMENT POLICY THAT WOULD UNDUE THESE LEGACY EFFECTS. THIS SEED GRANT WILL COLLECT AND LONGITUDINALLY LINK DATA IN PREPARATION FOR APPLYING FOR A FUTURE STANDARD GRANT SUBMISSION FROM AFRI. CONSISTENT WITH THE REQUIREMENTS OF SEED GRANTS, THIS WORK WILL THUS NOT FUND A STAND-ALONE PROJECT, BUT RATHER A PROJECT THAT WILL LEAD TO FURTHER WORK APPLICABLE TO THE RURAL ECONOMIC DEVELOPMENT AFRI PROGRAM AREA. SPECIFICALLY, THE LONG-TERM GOAL OF THIS SEED GRANT IS TO SPUR RURAL ECONOMIC GROWTH BY DEVELOPING A DATA FOUNDATION FOR RESEARCH-BASED KNOWLEDGE OF, AND THEREBY SUPPORT FOR, RURAL ECONOMIC GROWTH, WITH PARTICULAR ATTENTION TO MINORITIZED ETHNIC AND/OR RACIAL AND GENDER GROUPS. NEW, RESEARCHER-CONSTRUCTED DATASETS WILL BE FREELY RELEASED TO THE RESEARCH COMMUNITY TO FURTHER RESEARCH INTO OUTCOMES FOR MINORITIZED POPULATIONS IN RURAL AREAS.TO DEVELOP SPECIFIC RESEARCH QUESTIONS FROM INITIAL DATA TO BE ANSWERED THROUGH THE SUBMISSION OF A STANDARD GRANT PROJECT, THIS SEED GRANT WILL PROCEED IN THREE STEPS: (1) ENHANCE THE DOCUMENTATION OF THE HISTORICAL ADMINISTRATIVE BEHAVIOR OF FMHA AND FCA BY INVESTIGATING AND DIGITIZING RECORDS AT THE U.S. NATIONAL ARCHIVES AND RECORDS ADMINISTRATION (NARA); (2) WEB-SCRAPE PUBLIC ONLINE HISTORICAL RECORDS TO DEVELOP A DATASET OF THE HISTORICAL GEOGRAPHY OF FMHA AND FCA LOANS; (3) DEVELOP INTERGENERATIONAL (AND LONGITUDINAL) LINKAGES USING RESTRICTED-ACCESS MICRODATA FROM MULTIPLE FEDERAL AGENCIES.

23-RIA23-0044 EXOTIC CLOSE BINARIES IN GLOBULAR CLUSTERS

EAGER: LEADERSHIP WORKSHOPS AND FIELDWORK

EARMARKS

MRI: ACQUISITION OF AN ESI-TOF MASS SPECTROMETER BY TRINITY UNIVERSITY

RUI:COLLABORATIVE RESEARCH: UNDERSTANDING AND EXPLOITING PROTON MOBILITY IN AU CATALYZED SELECTIVE OXIDATION REACTIONS

RUI: PREPARATION AND CHARACTERIZATION OF DENDRIMER TEMPLATED AU-M NANOPARTICLES AND CATALYSTS

RUI: STUDYING THE PHOTODYNAMICS OF FRET PAIRED FLUORESCENT MOLECULES NEAR GOLD NANOGRATINGS

EAGER: PULSE PROJECT MANAGEMENT

RUI-ANTIAROMATIC HYDROCARBON DICATIONS AND HYDROCARBON/HETEROCYLIC DIANIONS: THE RELATIONSHIP BETWEEN DELOCALIZATION AND ANTIAROMATICITY

RUI: DEVELOPING A PREDICTIVE 3D MODEL OF STRAIN ACCOMMODATION DURING PROGRESSIVE FOLDING OF SANDSTONE -WHEN STRESSES BUILD WITHIN THE EARTH?S CRUST, FAULTS AND FOLDS FORM AS ROCK RELIEVES THOSE STRESSES. FAULTS AND FOLDS COMMONLY DISTORT AND FRACTURE THE ROCK AROUND THEM SO THAT FLUIDS CAN FLOW MORE EASILY. PROJECT RESEARCHERS WILL STUDY THE SAN RAFAEL MONOCLINE IN UTAH TO BETTER UNDERSTAND HOW FLUIDS FLOW IN THIS UNDERGROUND GEOLOGIC SYSTEM. THIS WILL HELPS SCIENTISTS TO BETTER UNDERSTAND GEOTHERMAL ENERGY POTENTIAL, PETROLEUM RESOURCE PRODUCTION, AND GROUNDWATER FLOW. THE RESULTS WILL PROVIDE SCIENTISTS AND NATURAL RESOURCE PROFESSIONALS WITH A PREDICTIVE MODEL THAT CAN BE APPLIED IN OTHER PLACES. PROJECT PARTICIPANTS WILL DEVELOP NEW SKILLS AND KNOWLEDGE THAT CAN BE APPLIED TO FUTURE CAREER OPPORTUNITIES IN GEOTHERMAL ENERGY EXPLORATION AND PRODUCTION. THE SAN RAFAEL MONOCLINE IN CENTRAL UTAH IS AN EXPOSED CONTRACTIONAL FAULT-PROPAGATION FOLD. PREVIOUS RESEARCH SHOWS CROSS SECTIONAL DEFORMATION BAND GEOMETRIES AND INTENSITIES ASSOCIATED WITH DIFFERENT STAGES OF FOLD DEVELOPMENT IN THE JURASSIC NAVAJO SANDSTONE. THIS PROJECT WILL BUILD ON THOSE RESULTS TO INCORPORATE BOTH MAP-VIEW AND FOLD-AXIS-PARALLEL CROSS-SECTIONAL VIEWS OF THE SYSTEM. THE 3D EVOLUTION OF THE FOLD WILL BE TESTED USING NUMERICAL MODELING. THE RESULTS WILL BE COMPARED TO MODELS DEVELOPED FROM FIELD AND 3D DATA ACQUIRED WITH DRONES. WITHIN THIS CONTEXT, THIS RESEARCH AIMS TO REVEAL THE LINK BETWEEN FAULT PROPAGATION FOLD DEVELOPMENT AND THE 3D EVOLUTION OF STRAIN IN POROUS SANDSTONE. BECAUSE FRACTURES, DEFORMATION BANDS, AND SMALL FAULTS ARE BELOW THE RESOLUTION OF SUBSURFACE METHODS, THESE RESULTS WILL INFORM MODELS OF PERMEABILITY FOR SIMILAR SYSTEMS IN THE SUBSURFACE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

USE OF PLANT SPECIES TRAITS TO DESIGN INVASION-RESISTANT COMMUNITIES

REU SITE: MULTI-AGENT SIMULATIONS OF SOCIAL SYSTEMS

RESEARCH INITIATION: UNDERSTANDING INTERACTIONS BETWEEN AFFECT AND IDENTITY IN FIRST- AND SECOND-YEAR ENGINEERING STUDENTS -RETENTION IN ENGINEERING PROGRAMS AND CAREERS IS A LONGSTANDING CONCERN IN ENGINEERING EDUCATION, PARTICULARLY AMONG HISTORICALLY UNDERREPRESENTED POPULATIONS. STUDENTS? DEVELOPMENT OF THEIR ENGINEERING IDENTITY, OR THE SENSE OF THEMSELVES AS BEING AN ENGINEER, IS KNOWN TO PLAY AN IMPORTANT ROLE IN THEIR DECISION TO PERSIST WITHIN THE MAJOR. WHILE THE DEVELOPMENT OF ENGINEERING IDENTITY HAS BEEN EXPLORED FROM MANY PERSPECTIVES, THE INFLUENCES OF STUDENTS? FEELINGS/EMOTIONS, VALUES, ATTITUDES, BELIEFS ABOUT THE SUBJECT HAVE NOT BEEN ADDRESSED. THIS RESEARCH SEEKS TO UNDERSTAND HOW STUDENTS? FEELINGS ASSOCIATED WITH LEARNING ENGINEERING, SCIENCE, AND MATHEMATICS AS WELL AS THEIR VALUES, ATTITUDES, AND BELIEFS ABOUT THOSE SUBJECTS, INTERACT WITH STUDENTS? DEVELOPMENT OF THEIR ENGINEERING IDENTITY. THIS PROJECT WILL FOLLOW PARTICIPANTS THROUGH THEIR FIRST TWO YEARS AS UNDERGRADUATE ENGINEERING STUDENTS, WHICH IS A CRITICAL TIME DURING WHICH STUDENTS DECIDE WHETHER TO PERSIST IN ENGINEERING. THIS WORK WILL IMPROVE UNDERSTANDING OF HOW STUDENTS? FEELINGS ABOUT THEIR EXPERIENCES IN MATHEMATICS, SCIENCE, AND ENGINEERING COURSES CONTRIBUTE TO THE FORMATION OF THEIR ENGINEERING IDENTITIES, WHICH IN TURN CONTRIBUTES TO THEIR DECISION TO PURSUE OR LEAVE ENGINEERING. BECAUSE STUDENTS? OTHER IDENTITIES SHAPE BOTH THEIR AFFECTIVE EXPERIENCES AND THE DEVELOPMENT OF THEIR ENGINEERING IDENTITY, WE WILL EXAMINE THE RELATIONSHIPS BETWEEN ENGINEERING IDENTITY AND AFFECT WITHIN THE CONTEXT OF STUDENTS? OTHER SOCIAL IDENTITIES. IN ADDITION TO SHAPING INSTRUCTOR PRACTICES TO HELP ALL STUDENTS EXPERIENCE POSITIVE IDENTITY-BUILDING AFFECTIVE EXPERIENCES, THIS WORK COULD THEREFORE SUPPORT PARTICIPATION AND RETENTION OF WOMEN AND UNDERREPRESENTED MINORITIES IN ENGINEERING, SUPPORTING THIS NSF PROGRAM?S GOAL OF MAKING PARTICIPATION IN ENGINEERING OPEN AND ACCESSIBLE TO ALL. EXISTING MODELS OF AFFECT AND ENGINEERING IDENTITY SEPARATELY SUGGEST THAT LOCAL AFFECT (THE CHANGING EMOTIONS THAT STUDENTS EXPERIENCE DURING DISCIPLINARY ACTIVITY) AND GLOBAL AFFECT (THE BROAD ATTITUDES, VALUES, AND BELIEFS THAT STUDENTS HOLD ABOUT A DISCIPLINE) MAY HAVE POTENTIAL TO INFLUENCE AND INTERACT WITH ENGINEERING IDENTITY, AND IN TURN, TO INFLUENCE RETENTION; HOWEVER, THESE LINKS HAVE NOT BEEN EXPLORED. THIS WORK WILL BUILD ON DISCIPLINARY LITERATURE IN MATHEMATICS AND SCIENCE EDUCATION ABOUT AFFECT, AS WELL AS THEORIES ON ENGINEERING IDENTITY DEVELOPMENT, IN ORDER TO CONTRIBUTE TO A THEORY OF HOW AFFECT PERTAINING TO SCIENCE, MATHEMATICS, AND ENGINEERING CONTRIBUTES TO STUDENTS? ENGINEERING IDENTITY. USING A MIXED-METHODS LONGITUDINAL APPROACH THAT FOLLOWS STUDENTS ACROSS THEIR FIRST TWO YEARS IN AN ENGINEERING PROGRAM, RESEARCHERS FROM TRINITY UNIVERSITY AND THE UNIVERSITY AT BUFFALO SEEK TO ANSWER THREE RESEARCH QUESTIONS: RQ1: HOW ARE FIRST- AND SECOND-YEAR ENGINEERING STUDENTS? LOCAL AFFECT DIFFERENT OR THE SAME WHILE DOING ENGINEERING WORK VS. MATHEMATICS AND SCIENCE WORK? RQ2: OVER THE COURSE OF THEIR EARLY COLLEGE EXPERIENCES WITH MATHEMATICS, SCIENCE, AND ENGINEERING, HOW DO STUDENTS? GLOBAL AFFECT ABOUT THESE DISCIPLINES CHANGE? RQ3: HOW DO STUDENTS? LOCAL AND GLOBAL AFFECT ABOUT MATHEMATICS, SCIENCE, AND ENGINEERING CONTRIBUTE TO/INTERACT WITH THEIR IDENTITIES, INCLUDING ENGINEERING IDENTITY? THE RESEARCH TEAM WILL INTERVIEW AND SURVEY ENGINEERING STUDENTS IN EACH OF THEIR FIRST FOUR SEMESTERS TO UNDERSTAND THESE STUDENTS? AFFECTS AND IDENTITIES. THE STUDY WILL CONTRIBUTE A SET OF CASE STUDIES BASED ON THE INTERVIEWS, FROM WHICH WE WILL DEVELOP A MODEL OF THE INTERACTIONS BETWEEN AFFECT AND ENGINEERING IDENTITY WHICH ALSO CONSIDERS THE INFLUENCE OF A RANGE OF OTHER STUDENT IDENTITIES ON SHAPING THOSE INTERACTIONS. ADDITIONALLY, THE STUDY WILL DEVELOP NEW INSTRUMENTS FOR MEASURING ENGINEERING AFFECT. THE INSTRUMENTS, MODEL, AND CASE STUDIES WILL INFORM EFFORTS TO IMPROVE RETENTION AND BROADEN PARTICIPATION IN ENGINEERING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

BREADTH AND DEPTH IN ELEMENTAL ANALYSIS

COLLABORATIVE RESEARCH: EXTENDED FAMILY SUPPORT AND HOUSING STABILITY OF YOUTH OVER TIME -FAMILY REJECTION IS A WELL-KNOWN CAUSE OF YOUTH HOMELESSNESS. THIS PROJECT EXTENDS A 1-YEARLONG STUDY IN TO A 2-YEARLONG STUDY TO UNDERSTAND HOW SUPPORT FROM EXTENDED FAMILY MEMBERS OVER TIME SHAPES PATHWAYS OF HOUSING STABILITY AND SAFETY BEFORE YOUTH END UP AT SHELTERS OR ON THE STREETS. THE LONGITUDINAL STUDY DOCUMENTS THE ROLES AND PRACTICES OF GRANDPARENTS, AUNTS, UNCLES, COUSINS, AND ADULT SIBLINGS IN PROVIDING LONG-TERM SHELTER AND HOUSING STABILITY FOR YOUTH WHOSE PARENTS ARE UNSUPPORTIVE OR AMBIVALENT ABOUT THEIR CHILDREN?S IDENTITIES AND BEHAVIORS. THE RESEARCH IS INNOVATIVE IN ITS FOCUS ON YOUTH WHO ARE EXPERIENCING CHALLENGES AT HOME BUT ARE NOT YET HOMELESS AND IN FOLLOWING THE YOUTH FOR 2 YEARS AS THEY TRANSITION INTO EMERGING ADULTS. THE STUDY ADVANCES THE SCIENCE ON FAMILIAL SOCIAL SUPPORT AND HOMELESSNESS. RESEARCHERS DRAW FROM THE STUDY?S FINDINGS TO ENGAGE IN OUTREACH TO YOUTH SHELTERS AND PROGRAMS AND INFORM PRACTITIONERS AND DECISION-MAKERS ON STRATEGIES TO PREVENT YOUTH HOMELESSNESS. TO UNDERSTAND THE ROLE OF NON-PARENTAL RELATIVES AND HOW THEIR SUPPORT SHAPES THE HOUSING STABILITY AND SAFETY OF YOUTH, THIS PROJECT EXTENDS A 1-YEARLONG STUDY OF 83 YOUTH (ORIGINALLY AGED 16-19) WHO ARE AT RISK OF HOMELESSNESS INTO A 2-YEAR MIXED-METHODS LONGITUDINAL STUDY. PARTICIPANTS WERE RECRUITED FROM TWO STATES IN THE SOUTHWEST UNITED STATES, INCLUDING YOUTH IN RURAL COMMUNITIES AND FROM MINORITY GROUPS. ORIGINAL DATA WERE COLLECTED THROUGH AN INITIAL INTERVIEW, 12 MONTHLY SURVEYS, AND A FOLLOW-UP INTERVIEW. THIS STUDY ADDS AN ADDITIONAL 12 MONTHLY SURVEYS AND ANOTHER FOLLOW-UP INTERVIEW, INCLUDING A LIFE HISTORY OF HOUSING INSTABILITY AND FAMILY SUPPORT. RESEARCHERS EVALUATE HOW THE FORMS AND CONSISTENCY OF INSTRUMENTAL AND EMOTIONAL SUPPORT THAT YOUTH RECEIVE FROM EXTENDED FAMILY OVER TIME INFLUENCE THEIR SENSE OF SAFETY AND HOUSING STABILITY. A LONGITUDINAL APPROACH ENABLES ANALYSIS OF HOW FAMILY SUPPORT AND HOUSING STABILITY AND SAFETY SHIFT OVER TIME AND AS THE YOUTH TRANSITION INTO EMERGING ADULTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

ERI:NETWORK BY NETWORK FABRICATION APPROACH OF BIOINSPIRED SCAFFOLDS TO STUDY THE EFFECT OF FIBRIN AND HYALURONIC ACID ON THE REACTIVE AND INFLAMMATORY RESPONSE OF HUMAN ASTROCYTES -THIS AWARD IS FUNDED IN WHOLE OR IN PART UNDER THE AMERICAN RESCUE PLAN ACT OF 2021 (PUBLIC LAW 117-2). INFLAMMATION OF THE NERVOUS TISSUE, NEUROINFLAMMATION, HAS BEEN INCREASINGLY RECOGNIZED AS A RISK FACTOR FOR THE PROGRESSIVE LOSS OF STRUCTURE OR FUNCTION OF NEURONS AND THE ONSET AND PROGRESSION OF NEUROLOGICAL DISORDERS. SEVERAL STUDIES HAVE IDENTIFIED CHANGES IN BRAIN TISSUE COMPOSITION AS KEY FACTORS IN REGULATING ACUTE AND CHRONIC INFLAMMATION IN THE CENTRAL NERVOUS SYSTEM (CNS). DUE TO THE DYNAMIC CHANGES, THE RELATIONSHIP BETWEEN CHANGES IN BRAIN TISSUE COMPOSITION AND NEUROINFLAMMATION REMAINS UNCLEAR. THIS ENGINEERING RESEARCH INITIATION (ERI) AWARD WILL INVESTIGATE THE RELATIONSHIP BETWEEN CHANGES IN BRAIN TISSUE COMPOSITION AND NEUROINFLAMMATION. TO ENABLE THIS STUDY, A BIOMATERIAL PLATFORM WILL BE DEVELOPED TO STUDY THE ABNORMAL BEHAVIOR OF HUMAN CELLS, CALLED ASTROCYTES, IN CNS TISSUE TRIGGERED BY CHANGES IN TISSUE COMPOSITION. THE EXECUTION OF THIS PROJECT WILL PROVIDE UNDERGRADUATE STUDENTS WITH HANDS-ON EXPERIENCE TO DEVELOP PROBLEM-SOLVING, LABORATORY, AND LEADERSHIP SKILLS AND TO PROMOTE THE STEM DISCIPLINES AMONG AT-RISK MIDDLE/HIGH SCHOOL STUDENTS. SEVERAL STUDIES HAVE IDENTIFIED THE EXTRACELLULAR MATRIX (ECM) AS A KEY FACTOR IN REGULATING ACUTE AND CHRONIC INFLAMMATION IN THE CENTRAL NERVOUS SYSTEM (CNS). TISSUE DAMAGE DUE TO AGING, TRAUMATIC BRAIN INJURY, AND NEURODEGENERATION CAUSES CHANGES IN THE COMPOSITION OF THE ECM. THESE CHANGES RESULT IN TISSUE DEGRADATION AND REMODELING. MOLECULES, SUCH AS HYALURONIC ACID, ARE DEGRADED INTO BIOACTIVE FRAGMENTS, WHILE COMPONENTS OF BLOOD PLASMA, SUCH AS FIBRINOGEN, ARE DEPOSITED IN THE FORM OF FIBRIN. ASTROCYTES ADJACENT TO INJURED TISSUE PROLIFERATE AND BECOME REACTIVE IN RESPONSE TO ECM CHANGES. CURRENTLY, THE RELATIONSHIP BETWEEN CHANGES IN BRAIN TISSUE ECM AND NEUROINFLAMMATION REMAINS UNCLEAR DUE TO DYNAMIC COMPOSITION OF THE ECM. TO STUDY THE MOLECULAR MECHANISM OF ECM COMPONENTS ON THE INFLAMMATORY RESPONSE OF CNS CELLS, NEW MODELS ARE NEEDED. THIS PROJECT WILL PROVIDE A PROOF-OF-PRINCIPLE FOR THE FABRICATION OF A 3D IN VITRO MODEL TO STUDY THE ONSET AND PROGRESSION OF INFLAMMATORY SIGNALING IN HUMAN ASTROCYTES. MULTI-INTERPENETRATING POLYMER NETWORKS (MIPNS), COMPRISED OF FIBRIN, HYALURONIC ACID HIGH MOLECULAR WEIGHT (HA-HMW), COLLAGEN TYPE I, AND POLY(ETHYLENE GLYCOL) DIACRYLATE WILL BE USED AS 3D SCAFFOLDS TO MIMIC KEY CHANGES IN MATRIX COMPOSITION (FIBRIN AND HA-HMW CONTENT) AND TO STUDY THEIR EFFECT ON ASTROCYTE REACTIVITY AND INFLAMMATORY RESPONSE. THE PROPOSED SCAFFOLDS WILL BE MADE USING A NETWORK-BY-NETWORK FABRICATION APPROACH. ORTHOGONAL CROSSLINKING MECHANISMS WILL BE USED TO CONTROL THE CROSSLINKING PROCESS DYNAMICALLY AND CHRONOLOGICALLY, ALLOWING FOR THE MODULATION OF SCAFFOLD RIGIDITY, PHYSICAL STABILITY, AND CELL MORPHOLOGY. THIS WORK WILL DEMONSTRATE THAT THE PROPOSED IN VITRO MODEL CAN BE USED TO UNCOVER KEY ELEMENTS CONNECTING ECM REMODELING AND THE REACTIVE AND INFLAMMATORY RESPONSE OF HUMAN ASTROCYTES. IN THE LONG TERM, THE DEVELOPMENT AND VALIDATION OF THE PROPOSED 3D MODEL WILL FURTHER CONTRIBUTE TO THE DESIGN, TESTING, AND EVALUATION OF NEW THERAPEUTIC MOLECULES TO TREAT CNS TISSUE DAMAGE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

VERB LEARNING: HOW DOES COMPARISON DEVELOP?

RICHARD ROLLE?S FIRE OF LOVE (INCENDIUM AMORIS): NEW EDITIONS, A NEW TRANSLATION, AND AN OPEN-ACCESS COMPANION WEBSITE [OUR PROPOSED PROJECT FOCUSES ON WHAT IS UNDOUBTEDLY THE MAJOR WORK OF THE MOST INFLUENTIAL AND AUTHORITATIVE RELIGIOUS WRITER OF LATE MEDIEVAL ENGLAND, THE HERMIT AND MYSTIC RICHARD ROLLE (C. 1300 - 1349). THE TEXT IN QUESTION, <EM>INCENDIUM AMORIS</EM> OR THE FIRE OF LOVE, SURVIVES IN SEVERAL DISTINCT FORMS, INCLUDING A MIDDLE ENGLISH TRANSLATION PREPARED BY AN EARLY DEVOTEE, RICHARD MISYN, AND OUR PROJECT TAKES ADVANTAGE OF THIS VARIETY TO ENHANCE THE IMPACT OF OUR WORK AND REACH A MORE DIVERSE SCHOLARLY AUDIENCE.]

RUI: COLLABORATIVE RESEARCH: TESTING MODELS FOR THE LATE JURASSIC NEVADAN OROGENY: AGE, PROVENANCE, AND STRUCTURAL EVOLUTION OF THE GALICE AND MARIPOSA BASINS, OR AND CA

RUI: DEVELOPING A PREDICTIVE MODEL OF STRAIN ACCOMMODATION FOR SEGMENTED NORMAL FAULT EVOLUTION, SEVIER FAULT ZONE, SOUTHERN UTAH

COLLABORATIVE RESEARCH: RUI: CONTINENTAL-SCALE STUDY OF JURA-CRETACEOUS BASINS AND MELANGES ALONG THE BACKBONE OF THE NORTH AMERICAN CORDILLERA-A TEST OF MESOZOIC SUBDUCTION MODELS -THE GEOLOGIC PROCESSES THAT FORMED THE NORTH AMERICAN CORDILLERA, MOUNTAINS THAT EXTEND FROM WESTERN MEXICO TO ALASKA, ARE DISPUTED. THESE MOUNTAIN RANGES AND NEIGHBORING BASINS (SUCH AS THE SIERRA NEVADA AND GREAT VALLEY BASIN WITHIN CALIFORNIA) ARE CONVENTIONALLY INTERPRETED TO HAVE FORMED DUE TO EASTWARD SUBDUCTION OF AN OCEANIC PLATE BENEATH THE WESTERN MARGIN OF THE NORTH AMERICAN CONTINENT. RECENT STUDIES CHALLENGE THIS MODEL AND PROPOSE THAT MUCH OF THE WESTERN CORDILLERA FORMED AS AN ARCHIPELAGO ABOVE WESTWARD SUBDUCTION OF AN OCEANIC PLATE FAR FROM THE MARGIN OF NORTH AMERICA. IN THIS ALTERNATIVE MODEL, THE ARCHIPELAGO BECAME PART OF THE CORDILLERA WHEN THE NORTH AMERICAN CONTINENT COLLIDED WITH THE ARCHIPELAGO. THIS CONTINENTAL-SCALE STUDY WILL TEST THESE MODELS ALONG FOUR EAST-WEST TRANSECTS ACROSS THE WESTERN CORDILLERA IN CENTRAL ALASKA, SE ALASKA, BRITISH COLUMBIA, AND CALIFORNIA. THE PROJECT WILL PROVIDE SUPPORT FOR FOUR PIS, TWO OF WHOM ARE FEMALE, THE PHD WORK OF THREE GRADUATE STUDENTS, AND EACH PI?S COMMITMENT TO PROVIDE UNDERGRADUATE STUDENTS WITH AUTHENTIC FIELD AND LABORATORY EXPERIENCES. THE RESEARCH METHODS ARE IDEAL FOR TRAINING UNDERGRADUATE STUDENTS TO THINK ACROSS A RANGE OF SPATIAL AND TEMPORAL SCALES IN THE CONTEXT OF FIELD OBSERVATIONS AND QUANTITATIVE ANALYSES, AND UNDERGRADUATE STUDENTS WILL BENEFIT FROM NEAR-PEER MENTORING BY GRADUATE STUDENTS. THE RESEARCHERS WILL ALSO LEAD A MULTI-DAY FIELD TRIP FOR NATIVE AMERICAN STUDENTS CENTERED ON THE CONNECTIONS BETWEEN GEOLOGIC PROCESSES THAT FORMED WESTERN NORTH AMERICA AND THE HOMELANDS OF INDIGENOUS COMMUNITIES. THE RESEARCH ADDRESSES THE FUNDAMENTAL PROBLEM OF DETERMINING SUBDUCTION POLARITY ALONG ANCIENT CONVERGENT MARGINS. THIS PROJECT WILL COUPLE THE STUDY OF M?LANGE BELTS WITH BASIN STRATA, AND INTEGRATE THE RESULTS ALONG THE HYPOTHESIZED CONTINENTAL-SCALE SUTURE WITHIN THE NORTH AMERICAN CORDILLERA. THIS COLLABORATIVE PROJECT WILL EVALUATE 1) THE AGE AND PROVENANCE OF M?LANGE BELTS, 2) THE BASINS? STRUCTURAL AND SEDIMENTOLOGICAL CONFIGURATION (INCLUDING INBOARD AND OUTBOARD CONTACTS), 3) THE TIMING OF BASIN FORMATION AND SUBSEQUENT COLLAPSE, AND 4) BASIN AND M?LANGE PROVENANCE COMPARISON IN THE CONTEXT OF EAST-DIPPING VERSUS WEST-DIPPING SUBDUCTION. ANALYSIS OF THE BASIN STRATA AND ADJACENT M?LANGE BELTS USING DETRITAL ZIRCON ANALYSIS (U-PB, LU-HF, AND TRACE ELEMENT GEOCHEMISTRY), SANDSTONE PETROGRAPHY, AND WHOLE-ROCK SM-ND ISOTOPIC ANALYSIS AND TRACE-ELEMENT GEOCHEMISTRY WILL PROVIDE A CONTINENTAL-SCALE TEST OF PROPOSED MODELS TO BETTER UNDERSTAND THE MESOZOIC DEVELOPMENT OF THE NORTH AMERICAN CORDILLERA. THIS PROJECT WILL ALSO REFINE METHODS FOR ESTABLISHING THE GEOMETRY AND TIMING OF CONVERGENT MARGIN SYSTEMS IN OTHER OROGENS, PARTICULARLY PRE-MESOZOIC SYSTEMS FOR WHICH TOMOGRAPHIC INFORMATION IS NOT AVAILABLE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

RUI-BENZANNULATED ANTIAROMATIC DICATIONS AND DIANIONS: USING ANTIAROMATICITY TO PROBE DELOCALIZATION

ROBERT NOYCE SCHOLARSHIPS AT TRINITY UNIVERSITY

WATER-ASSISTED OXYGEN INSERTION REACTIONS OVER SUPPORTED GOLD CATALYSTS

TRINITY UNIVERSITY RESEARCH EXPERIENCES FOR UNDERGRADUATES IN MATHEMATICS

COLLABORATIVE RESEARCH: SEARCHING FOR THE EXPELLED ENVELOPES OF STRIPPED-ENVELOPE SUPERNOVAE

RUI: MOLECULAR TRACER DIFFUSION MEASUREMENTS WITHIN THE BIOMIXING GENERATED BY SWIMMING E. COLI

COLLABORATIVE RESEARCH: RUI: PROVENANCE AND PALEOMAGNETIC ANALYSIS OF THE OCHOCO BASIN: A WINDOW INTO LATE CRETACEOUS PALEOGEOGRAPHY

RUI: ALGORITHMS AND MODELING FOR CHEMOTACTIC DEFORMABLE PARTICLES IN NON-NEWTONIAN, MULTIPHASE, NON-ISOTHERMAL, TURBULENT FLOWS

EXECUTE A BALANCED SCIENCE PROGRAM BASED ON DISCIPLINE-SPECIFIC GUIDANCE FROM THE NATIONAL ACADEMIES OF SCIENCES ENGINEERING AND MEDICINE ADMINISTRATION PRIORITIES AND DIRECTION FROM CONGRESS. PARTICIPATE AS A KEY PARTNER AND ENABLER IN THE AGENC

DIRECTED GRANTS

RUI: EXPLORING CHARGING ISSUES IN THIRD-GENERATION GRAVITATIONAL-WAVE INTERFEROMETERS

COLLABORATIVE RESEARCH RUI: TESTING MECHANISMS FOR REGIONAL DOLOMITIZATION OF TRIASSIC CARBONATE PLATFORMS ACROSS THE NANPANJIANG BASIN OF SOUTH CHINA

MRI: ACQUISITION OF EQUIPMENT TO ESTABLISH A DISTRIBUTED INTELLIGENT AGENT SYSTEMS INFRASTRUCTURE FOR RESEARCH AND EDUCATION AT TRINITY UNIVERSITY

COLLABORATIVE RESEARCH: RUI: ATOMIC COLLISIONS WITH TRAPPED IONS IN ULTRACOLD HYBRID SYSTEMS -HYBRID SYSTEMS CONSISTING OF TRAPPED IONS IMMERSED IN AN ULTRACOLD GAS OF NEUTRAL ATOMS OFFER EXCITING NEW OPPORTUNITIES FOR QUANTUM SCIENCE AND TECHNOLOGY THAT BENEFIT FROM DECADES OF ADVANCES MADE WITH EACH OF THESE RESPECTIVE SYSTEM CONSTITUENTS. WHILE COLLISION PROCESSES BETWEEN IONS AND NEUTRAL ATOMS IN FREE SPACE HAVE RECEIVED THEORETICAL ATTENTION, A FULLY QUANTUM MECHANICAL DESCRIPTION OF SUCH COLLISIONS THAT INCLUDES THE ION CONFINEMENT REMAINS LARGELY UNEXPLORED DESPITE THE FACT THAT RECENT EXPERIMENTAL ADVANCES HAVE REALIZED SUCH SYSTEMS IN THE LAB. THE RESEARCH TEAM WILL DEVELOP A FULLY QUANTUM MECHANICAL DESCRIPTION OF COLLISION PROCESSES BETWEEN NEUTRAL ATOMS AND TRAPPED IONS. SUCH A THEORY IS NECESSARY TO INFORM ONGOING AND NEAR-FUTURE EXPERIMENTS, PAVING THE WAY FOR ULTRACOLD HYBRID ATOM-ION SYSTEMS AS AVENUES TO STUDY ATOM-ION CHEMISTRY, PROBES OF MANY-BODY PHYSICS IN ATOMIC GASES, OR AS PLATFORMS FOR OTHER APPLICATIONS IN QUANTUM INFORMATION SCIENCE. THIS WORK WILL BE CARRIED OUT AT PRIMARILY UNDERGRADUATE INSTITUTIONS, INTRODUCING STUDENTS OF DIVERSE BACKGROUNDS TO METHODOLOGIES IN MODERN THEORETICAL PHYSICS, AND PROVIDING UNDERGRADUATES WITH AN OPPORTUNITY TO MAKE MEANINGFUL CONTRIBUTIONS TO MODERN SCIENTIFIC RESEARCH. IN PARTICULAR, THE RESEARCH TEAM WILL INVESTIGATE COLLISIONAL RESONANCES THAT ARISE AS A CONSEQUENCE OF THE ION CONFINEMENT, AND USE INSIGHTS GAINED FROM THE STUDY OF SINGLE ION SYSTEMS TO GUIDE THE TREATMENT OF SYSTEMS WITH TWO OR MORE IONS. THE PROPOSED COLLISION THEORY CONSTITUTES A MARRIAGE OF TWO POWERFUL METHODOLOGIES THAT HAVE EACH PLAYED A PIVOTAL ROLE IN SCATTERING THEORY AND FEW-BODY PHYSICS: MULTICHANNEL QUANTUM DEFECT THEORY (MQDT), AND THE ADIABATIC HYPERSPHERICAL METHOD. A SUCCESSFUL INTEGRATION OF THESE METHODOLOGIES COULD POTENTIALLY BE APPLIED TO OTHER FEW-BODY SYSTEMS WELL BEYOND THE ATOM-ION PROBLEM. THE GOALS OF THE PROJECT ARE TO (1) REFINE A PRELIMINARY ONE-DIMENSIONAL MODEL BASED ON SINGLE-CHANNEL ATOM-ION INTERACTIONS WITH IONIC CONFINEMENT AND EXTEND IT TO THREE DIMENSIONS, COMPUTING OBSERVABLES SUCH AS ELASTIC AND INELASTIC COLLISION RATES AND TIME DELAYS. (2) INCORPORATE MULTICHANNEL INTERACTIONS THAT INCLUDE THE INTERNAL MAGNETIC STRUCTURE OF THE COLLISION PARTNERS AND INVESTIGATE THE CONSEQUENCES OF ION TRAP MICROMOTION. (3) BUILDING ON INSIGHTS FROM PRECEDING EFFORTS, FORMULATE A MODEL FOR HYBRID SYSTEMS OF ATOMS AND MULTIPLE IONS, WITH PARTICULAR EMPHASIS ON UNDERSTANDING HOW A COLLISION EVENT COUPLES TO THE ENTANGLED MOTIONAL STATE OF AN ION CRYSTAL. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

COLLABORATIVE RESEARCH: EXPLORING THE ROLE OF ORGANICS IN ATMOSPHERIC CONTACT NUCLEATION

RUI: COUPLED FOLD-FRACTURE EVOLUTION IN THE STILLWELL ANTICLINE, WEST TEXAS

RUI -- FURTHER OPTICAL CHARGE STUDIES WITH THE TRINITY UNIVERSITY KELVIN PROBE

INCENTIVES IN THE WORKPLACE: AN EXPERIMENTAL EXAMINATION OF HOW WAGE DIFFERENCES ACROSS TIME AND AMONG PEERS AFFECT PRODUCTIVITY AND SELF-SELECTION

COLLABORATIVE RESEARCH: DMS/NIGMS2: COMPUTATIONAL AND EXPERIMENTAL ANALYSIS OF CHOANOFLAGELLATE HYDRODYNAMIC PERFORMANCE - SELECTIVE FACTORS IN THE EVOLUTION OF MULTICELLULARITY

RUI: OPTICAL CHARGE MITIGATION STUDIES WITH THE TRINITY UNIVERSITY KELVIN PROBE

THE TRINITY MARKET A UNIVERSITY ENRICHE

THE TRINITY MARKET: A UNIVERSITY ENRICHED FARMER, RANCHERS AND HEALTHY LIFESTYLES MARKET. FMPP GRANT PROGRAM

COLLABORATIVE RESEARCH: ACTIVE, UPPER PLATE DEFORMATION IN RESPONSE TO MIGRATION OF THE PANAMA TRIPLE JUNCTION, PACIFIC COAST, PANAMA AND COSTA RICA

SGER -- MEASURING CHARGING EFFECTS ON LIGO OPTICS

PATENT UNCERTAINTIES AND INTERNATIONAL INNOVATION

THE STUDENT MANAGED EARLY STAGE VENTURE FUND WILL FOCUS ON EARLY-STAGE STARTUPS WITH HIGH-GROWTH POTENTIAL. TRINITY SMEVF WILL BE SUPPORTED BY A COMBINATION OF TRINITY UNIVERSITY FUNDING AND PHILANTHROPIC DONATIONS TO THE UNIVERSITY. AS AN EDUCATIONAL, PHILANTHROPIC SOURCE OF CAPITAL, THE TRINITY SMEVF WILL BE AN OPEN-ENDED, EVERGREEN FUND WITH THE MISSION OF EDUCATING STUDENTS, SUPPORTING HIGH-GROWTH EARLY STAGE START-UPS IN SAN ANTONIO AND IN THE USEDA AUSTIN REGION, AND SUSTAINING THIS IMPACT THROUGH REINVESTMENT INTO THE FUND'S CORPUS. BY 2027, THEY PROJECT INVESTMENTS IN MORE THAN 50 COMPANIES IN THE REGION, CREATION OF MORE THAN 125 NEW JOBS, AND EVERGREEN SUPPORT FOR TRINITY SMEVF. IT WILL ALSO INVEST IN UNDERREPRESENTED FOUNDERS WITH A MINIMUM OF 30% OF ITS INVESTMENTS TARGETED AT VENTURES LED BY WOMEN OF ALL BACKGROUNDS, BLACK, LATINX, AND INDIGENOUS, LGBTQ+, AND LOW-INCOME BACKGROUND FOUNDERS.

COLLABORATIVE RESEARCH: HUMIDITY AND TEMPERATURE EFFECTS ON PHASE SEPARATION AND PARTICLE MORPHOLOGY IN INTERNALLY MIXED ORGANIC-INORGANIC AEROSOL

RUI: NUMERICAL SIMULATION OF COLLISIONAL DYNAMICS IN PLANETARY SYSTEMS

SUMMER SYMPOSIUM IN REAL ANALYSIS XLIII

RAPID/COLLABORATIVE RESEARCH: DIGITIZING EARLY CRETACEOUS DINOSAUR TRACKWAYS TO PRESERVE THE GEOLOGICAL HERITAGE OF CENTRAL TEXAS

COLLABORATIVE RESEARCH: A DETRITAL ZIRCON RECORD OF CALIFORNIA ARC MAGMATISM

THE THIRD INTERNATIONAL CONFERENCE ON MATHEMATICAL MODELING AND ANALYSIS OF POPULATIONS IN BIOLOGICAL SYSTEMS

USE OF PLANT SPECIES TRAITS TO DESIGN INVASION-RESISTANT COMMUNITIES