Trustees Of Dartmouth College

CANCER CENTER SUPPORT GRANT

NEW HAMPSHIRE IDEA NETWORK OF BIOLOGICAL RESEARCH EXCELLENCE (NH-INBRE)

A PROSPECTIVE STUDY OF CRITICAL ENVIRONMENTAL EXPOSURES IN FORMATIVE EARLY LIFE THAT IMPACT LIFELONG HEALTH IN RURAL US CHILDREN: THE NEW HAMPSHIRE BIRTH COHORT STUDY

CAUSES AND CONSEQUENCES OF HEALTH CARE EFFICIENCY

NORTHEAST NODE OF THE NATIONAL DRUG ABUSE CLINICAL TRIALS NETWORK

TOXIC METALS IN THE NORTHEAST: FROM BIOLOGICAL TO ENVIRONMENTAL IMPLICATIONS

ITARGET: INSTITUTE FOR BIOMOLECULAR TARGETING

HEALTHCARE INNOVATION CHALLENGETHE HIGH VALUE HEALTHCARE COLLABORATIVE: ENGAGING PATIENTS TO MEET THE TRIPLE AIM

CENTER FOR QUANTITATIVE BIOLOGY: A FOCUS ON "OMICS", FROM ORGANISMS TO SINGLE CELLS

CENTER FOR MOLECULAR EPIDEMIOLOGY

ICE DRILLING PROGRAM OFFICE

TECHNOLOGY-BASED TREATMENTS FOR SUBSTANCE USE DISORDERS

ACCELERATING THE USE OF EVIDENCE-BASED INNOVATION IN HEALTHCARE SYSTEMS

SYNERGY: THE DARTMOUTH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE

A PROSPECTIVE STUDY OF CRITICAL ENVIRONMENTAL EXPOSURES IN FORMATIVE EARLY LIFE THAT IMPACT LIFELONG HEALTH IN RURAL US CHILDREN: THE NEW HAMPSHIRE B

PHYSICALLY-BASED BIODOSIMETRY FOR TRIAGE AFTER A LARGE RADIATION INCIDENT

ICE DRILLING PROGRAM OFFICE

DARTCF: THE DARTMOUTH CYSTIC FIBROSIS RESEARCH CENTER

FUNCTIONAL ANALYSIS OF A MODEL FILAMENTOUS FUNGUS

DARTMOUTH CENTER FOR CANCER NANOTECHNOLOGY EXCELLENCE

TRANSDISCIPLINARY RESEARCH IN CANCER OF THE LUNG (TRICL)

CELLULAR AND MOLECULAR MECHANISMS OF LUNG DISEASE

ADVANCED SURGICAL CENTER FOR TRANSLATIONAL RESEARCH AT DARTMOUTH

VISUAL MEDIA INFLUENCES ON ADOLESCENT SMOKING BEHAVIOR (Y10-14 RENEWAL)

MECHANISMS OF MEMBRANE FUSION

QUANTITATIVE BIOLOGY RESEARCH INSTITUTE

PROTEIN COMPARTMENTATION

THE NEURAL BASES OF PLACEBO EFFECTS AND THEIR RELATION TO REGULATORY PROCESSES

VIRAL & HOST FACTORS IN HERPETIC REACTIVATION

DARTMOUTH COLLEGE INSTITUTIONAL EMERGENCY GRANT UNDER CARES ACT

CENTER FOR MOLECULAR, CELLULAR, AND TRANSLATIONAL IMMUNOLOGICAL RESEARCH

ICE DRILLING PROGRAM -THIS AWARD PROVIDES SUPPORT TO THE ICE DRILLING PROGRAM (IDP) TO PROVIDE COMMUNITY LEADERSHIP AND TO OPERATE AND MAINTAIN A FACILITY TO SUPPORT ICE DRILLING ENGINEERING, FIELD SUPPORT, AND EDUCATION AND OUTREACH. THE INTELLECTUAL MERIT OF THIS PROJECT IS EMBODIED IN THE FOUR CLOSELY LINKED LEADERSHIP GOALS OF THIS PROJECT WHICH INCLUDE: 1) PRODUCING AND MAINTAINING LONG-TERM AND SHORT-TERM INTEGRATED SCIENCE AND DRILLING TECHNOLOGY PLANS IN COLLABORATION WITH THE U.S. AND INTERNATIONAL ICE CORING AND DRILLING RESEARCH COMMUNITIES, 2) PROVIDING FIELD SUPPORT WITH DRILLING EQUIPMENT AND EXPERTISE TO SUPPORT NSF-FUNDED SCIENCE, 3) IDENTIFYING NEW TECHNOLOGY NEEDS AND SEEKING FUNDING FOR TECHNOLOGY DEVELOPMENT AND ACQUISITION, AND 4) ENHANCING COMMUNICATION AND INFORMATION EXCHANGE RELATED TO ICE CORING AND DRILLING SCIENCE AND TECHNOLOGY WITHIN THE US AND INTERNATIONAL ICE SCIENCE COMMUNITY. THESE GOALS RELATE TO THE IMPORTANCE OF EVIDENCE FROM THE POLAR ICE SHEETS FROM ICE CORES, SUBGLACIAL BEDROCK CORES, AND BOREHOLES TO ACCESS THE SUBGLACIAL AQUEOUS ENVIRONMENT, WHICH HAS LED TO MANY IMPORTANT DISCOVERIES THAT HAVE REVOLUTIONIZED CLIMATE SCIENCE. THESE DISCOVERIES HAVE ALSO HAD IMPORTANT IMPACTS ON POLICY AND THUS ALSO HAVE SOCIETAL RELEVANCE. CONTINUED U.S. SCIENTIFIC LEADERSHIP IN THIS AREA DEPENDS CRITICALLY NOT ONLY ON THE SUPPORT OF SCIENTISTS DOING THIS RESEARCH BUT ALSO ON THE CONTINUED SUPPORT OF A DEDICATED FACILITY TO PROVIDE THE FIELD DRILLING SUPPORT AND ACCOMPLISH ENGINEERING AND TECHNOLOGY DEVELOPMENT ACTIVITIES. THIS PROGRAM AND ITS EDUCATION AND PUBLIC OUTREACH ACTIVITIES WILL NURTURE THE INCLUSION OF STUDENTS OF MANY AGES, RACES, AND GENDERS, WILL HELP TO LAUNCH GRADUATE STUDENTS INTO PROMISING CAREERS, AND THE RESULTING SCIENTIFIC DISCOVERIES WILL BENEFIT ALL CITIZENS. ACHIEVING THE GOALS OF THIS PROJECT WILL ENABLE THE U.S. ICE SCIENCE RESEARCH COMMUNITY TO REALIZE IMPLEMENTATION OF THEIR NATIONAL AND INTERNATIONALLY-COORDINATED SCIENTIFIC GOALS, LEAD THE WORLD IN ICE SCIENCE DISCOVERIES, NURTURE THE EDUCATION AND DEVELOPMENT OF THE NEXT GENERATION OF SCIENTISTS AND ENGINEERS, AND HELP TO COMMUNICATE THE IMPORTANCE OF THE DISCOVERIES TO ALL. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

LINKING ACTIN CYTOSKELETON TO MEMBRANE DYNAMICS IN MITOCHONDRIAL FISSION

BALLOON ARRAY FOR RSBP RELATIVISTIC ELECTRON LOSSES (BARREL)THE BARREL PROPOSAL PRESENTED A PERSUA

NH MCH LEADERSHIP TRAINING PROGRAM

GENETIC AND MOLECULAR DISSECTION OF THE NEUROSPORA CLOCK

INTEGRATED FOUNDATIONS OF SENSING, MODELING, AND DATA ASSIMILATION FOR SEA ICE PREDICTION

DIRECT AND REPEATED CLINICAL MEASUREMENT OF PO2 FOR ENHANCING CANCER THERAPY

DARTMOUTH COLLEGE EMERGENCY FINANCIAL AID GRANTS UNDER CARES ACT

FINANCIAL ASSISTANCE, AS MANDATED BY CONGRESS, TO THAYER SCHOOL OF ENGINEERING OF DARTMOUTH COLLEGE

ORGANIZATION OF THE MAMMALIAN MITOTIC SPINDLE

NEW HAMPSHIRE IDEA NETWORK OF BIOLOGICAL RESEARCH EXCELLENCE (NH-INBRE)

IMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLS

HEARING IMPAIRMENT IN HIV-INFECTED AND HIV/TB-COINFECTED INDIVIDUALS IN TANZANIA

DARTMOUTH LUNG BIOLOGY CENTER FOR MOLECULAR, CELLULAR AND TRANSLATIONAL RESEARCH

NIAMS MULTIDISCIPLINARY CLINICAL RESEARCH CENTER

ADVANCING SYSTEMS APPROACHES TO PERSONAL AND POPULATION BREAST CANCER SCREENING

RII TRACK-2 FEC: NEURAL BASIS OF ATTENTION

RII TRACK-2 FEC: COMPUTATIONAL METHODS AND AUTONOMOUS ROBOTICS SYSTEMS FOR MODELING AND PREDICTING HARMFUL CYANOBACTERIAL BLOOMS

REGULATION OF HOST INNATE AND ADAPTIVE IMMUNITY BY BACTERIAL TYPE III EFFECTORS

NOVEL PEDIATRIC NEUROCOGNITIVE SCREENING USING CENTRAL AUDITORY TESTS

HUMAN AND MOUSE TRANSCRIPTOME PROFILING IDENTIFIES CROSS-SPECIES HOMOLOGY OF MONONUCLEAR PHAGOCYTES - PROJECT SUMMARY/ABSTRACT THE MONONUCLEAR PHAGOCYTE (MP) SYSTEM PLAYS A FUNDAMENTAL ROLE IN BOTH INNATE AND ADAPTIVE IMMUNITY. IT INCLUDES THREE BROAD CLASSES OF MPS EXTENSIVELY CHARACTERIZED IN THE MOUSE: (1) MACROPHAGES, INCLUDING ALVEOLAR MACROPHAGES, LANGERHANS CELLS, AND THREE DISTINCT SUBTYPES OF INTERSTITIAL MACROPHAGES; (2) TISSUE-TRAFFICKING MONOCYTES; AND (3) DENDRITIC CELLS (DCS), WHICH FALL INTO TWO MAIN TYPES (DC1 AND DC2), THOUGH DC2 CAN BE FURTHER SUBDIVIDED. ALL THESE MPS, EXCEPT AMS AND LCS, WHICH ARE UNIQUE TO LUNG AND SKIN, RESIDE IN MULTIPLE ORGANS, INCLUDING THE HEART, SKIN, LIVER, AND GUT. MP SUBTYPES DEMONSTRATE A CLEAR DIVISION OF LABOR DURING INNATE AND ADAPTIVE IMMUNITY WITH LITTLE TO VIRTUALLY NO FUNCTIONAL REDUNDANCY, WHICH MEANS THAT SPECIFIC INTERACTIONS AMONG THEM ARE CRUCIAL FOR OPTIMAL IMMUNE RESPONSES AGAINST VIRAL, BACTERIAL, AND FUNGAL INFECTIONS. CURRENTLY, HOWEVER, MULTIPLE FUNDAMENTAL GAPS FOR THE IDENTIFICATION AND UNDERSTANDING OF HOW THESE MPS FUNCTION IN HUMAN ORGANS LIMIT OUR ABILITY TO DEVELOP PREVENTION AND TREATMENT STRATEGIES ACROSS DISEASES. THIS PROJECT WILL INVESTIGATE CROSS-SPECIES AND CROSS-TISSUE HOMOLOGIES AT THE CELLULAR, GENE EXPRESSION AND FUNCTIONAL LEVELS. WE WILL OBTAIN FRESH HUMAN AND MOUSE TISSUE FROM MULTIPLE ORGANS (LUNG, SKIN, AND THEIR DRAINING LYMPH NODES), AND EMPLOY THREE BROAD APPROACHES. FIRST, WE WILL USE BOTH BULK RNA SEQUENCING (RNA-SEQ) AND SINGLE-CELL RNA SEQUENCING (SCRNA-SEQ) TO IDENTIFY CROSS-SPECIES AND CROSS-TISSUE HOMOLOGY. RNA-SEQ PROVIDES SEQUENCING DEPTH (I.E., WHOLE-TRANSCRIPTOME COVERAGE), AND SCRNA-SEQ PROVIDES THE ABILITY TO CONFIRM BULK HOMOLOGOUS MP SUBTYPES AND EXAMINE THE HETEROGENEITY WITHIN PREVIOUSLY DEFINED MP SUBTYPES. THUS, BIOINFORMATICS ANALYSES WILL IDENTIFY CLUSTERS OF HOMOLOGOUS MP CELL TYPES AND ALIGN THEM ACROSS SPECIES. SECOND, FOR EACH CLUSTER IDENTIFIED, WE WILL IDENTIFY GENES CONSERVED ACROSS SPECIES AND TISSUES, AND THOSE THAT ARE UNIQUE TO A GIVEN HOMOLOGOUS MP SUBTYPE, TERMED MARKER GENES. THE RESULTS OF THESE ANALYSES WILL PROVIDE SPECIFIC GENETIC MARKERS FOR HUMAN MP SUBTYPES AND GENETIC TREATMENT TARGETS. BROADLY SPEAKING, THERE ARE TWO CATEGORIES OF KEY MARKER GENES WE WILL FUNCTIONALLY INVESTIGATE: THOSE CONSERVED IN HUMAN-MOUSE MP COUNTERPARTS THAT (1) HAVE BEEN WELL-DEFINED IN MICE, BUT NOT PREVIOUSLY INVESTIGATED IN THEIR HUMAN COUNTERPARTS; AND (2) NOT WELL-DEFINED OR EXTENSIVELY STUDIED IN EITHER SPECIES. THIRD, WE WILL UNDERTAKE A RIGOROUS FUNCTIONAL VALIDATION OF THE KEY GENES IDENTIFIED IN HUMAN-MOUSE MP COUNTERPARTS. THIS INCLUDES (A) IN-VIVO MURINE MODELS WITH SELECTIVE DEPLETION OF SPECIFIC GENES USING TRANSGENIC AND CONDITIONAL KNOCKOUT (KO) MICE; (B) IN VITRO MODEL SYSTEMS FOR HUMAN MPS, INCLUDING ASSAYS FOR ANTIGEN ACQUISITION AND PROCESSING, CELLULAR INTERACTIONS, AND INDUCTION OF ADAPTIVE IMMUNE RESPONSES; AND (C) CREATE TIME-LAPSE VIDEOS WITH CELLULAR-LEVEL MICROSCOPY FOR FUNCTIONAL AND MORPHOLOGICAL CHARACTERIZATION.

DEVELOPMENT OF SPIN PROBES FOR CELL-TAGGING AND OXIMETRY

SATC: FRONTIERS: COLLABORATIVE: SECURITY AND PRIVACY IN THE LIFECYCLE OF IOT FOR CONSUMER ENVIRONMENTS (SPLICE)

IDENTIFICATION AND ANALYSIS OF CIRCADIAN CLOCK-CONTROLLED GENES

GENETIC AND MOLECULAR DISSECTION OF THE NEUROSPORA CLOCK

MOLECULAR FLUORESCENCE-GUIDED SURGERY PLATFORM

NON-MELANOMA SKIN CANCER IN NEW HAMPSHIRE

BEHAVIORAL TREATMENT OF ADOLESCENT MARIJUANA USE

PREOPERATIVE IMAGE UPDATING FOR GUIDANCE DURING BRAIN TUMOR RESECTION

GENETIC ANALYSIS OF NATURAL VARIATION IN THE CONTROL OF WATER USE EFFICIENCY AND RESPONSE TO DROUGHT STRESS IN BRASSICA RAPA

FUNCTIONAL ANATOMIC STUDIES OF INTERPERSONAL DISTRESS

CENTER FOR IMPLEMENTATION SCIENCE - SUMMARY THE OVERARCHING GOAL OF THIS COBRE IS TO ESTABLISH A MULTIDISCIPLINARY RESEARCH PROGRAM IN IMPLEMENTATION SCIENCE AT DARTMOUTH COLLEGE AND TO PROVIDE TRAINING, EXPERT MENTORSHIP AND NEW SCIENTIFIC INFRASTRUCTURE TO TRAIN AND SUPPORT A CRITICAL MASS OF EARLY-STAGE INVESTIGATORS AS THEY TRANSITION INTO INDEPENDENT INVESTIGATORS DEDICATED TO ADVANCING THE FIELD OF IMPLEMENTATION SCIENCE. IMPLEMENTATION SCIENCE IS THE STUDY OF METHODS TO PROMOTE THE INTEGRATION OF RESEARCH FINDINGS AND EVIDENCE INTO HEALTHCARE POLICY AND PRACTICE AS A CRITICAL EMERGING DISCIPLINE IN BIOMEDICAL RESEARCH. THIS MULTIDISCIPLINARY FIELD COMBINES METHODS FROM MEDICAL ANTHROPOLOGY, HEALTHCARE AND BEHAVIORAL ECONOMICS, INTERVENTION EFFECTIVENESS AND PROCESS RESEARCH, IMPROVEMENT SCIENCE, EDUCATION AND LEARNING, SOCIAL PSYCHOLOGY, ORGANIZATION AND MANAGEMENT, AND MARKETING. CURRENTLY, THERE IS $3 BILLION ANNUALLY IN FEDERAL FUNDING FOR IMPLEMENTATION RESEARCH. YET, THERE IS A CRITICAL GAP IN ACADEMIC DEVELOPMENT OPPORTUNITIES FOR JUNIOR FACULTY TO BE TRAINED AND MENTORED IN THE IMPLEMENTATION SCIENCES OR RESOURCES TO INCREASE THEIR ACADEMIC TRAJECTORY TOWARDS INDEPENDENCE. DESPITE THE ESCALATION IN FUNDING AND THE UNIQUE NEEDS OF IDEA STATES FOR EFFECTIVE BIOMEDICAL HEALTH INTERVENTIONS, IDEA STATES CONTINUE TO LAG IN IMPLEMENTATION RESEARCH FUNDING. THEREFORE, WE PROPOSE TO BUILD STATE-OF-THE-ART INFRASTRUCTURE IN IMPLEMENTATION SCIENCE TO ACCELERATE BIOMEDICAL RESEARCH FUNDING FOR IMPLEMENTATION IN THE IDEA STATE OF NEW HAMPSHIRE, AND CREATE SYSTEMS AND TRAINING OPPORTUNITIES FOR USE BY OTHER IDEA STATES REGIONALLY AND NATIONWIDE. OUR PROPOSED CENTER FOR IMPLEMENTATION SCIENCE, SUPPORTED BY CENTERS OF BIOMEDICAL RESEARCH EXCELLENCE (COBRE) MECHANISM, WILL SUPPORT AND ADVANCE RESEARCH BY JUNIOR FACULTY, BUILDING ON DARTMOUTH’S RECOGNIZED ACADEMIC AND RESEARCH EXCELLENCE. THE PROPOSED CENTER WILL SUPPORT FIVE RESEARCH PROJECT LEADERS AND WILL ADDRESS THE FOLLOWING SPECIFIC AIMS: AIM 1: TO ESTABLISH A MULTIDISCIPLINARY COBRE CENTER FOR IMPLEMENTATION SCIENCE; AIM 2: TO IMPLEMENT AND SUSTAIN A VIBRANT ORGANIZATION AND MANAGEMENT PLAN FOR THE CENTER; AND AIM 3: TO ACCELERATE THE TRANSITION OF JUNIOR FACULTY INTO NIH GRANT- COMPETITIVE, STRONG? INDEPENDENT INVESTIGATORS. IMPACT: THE PROPOSED CENTER FOR IMPLEMENTATION SCIENCE WILL PROVIDE NEEDED FUNDING, NEW SCIENTIFIC RESOURCES, AND MENTORSHIP TO ADVANCE JUNIOR FACULTY INTO INDEPENDENT RESEARCH CAREERS FOCUSED ON THE STUDY AND APPLICATION OF IMPLEMENTATION SCIENCE. THE INITIAL RESEARCH PROJECTS WILL SUPPORT THE DEVELOPMENT OF A SELF-SUSTAINING, MULTIDISCIPLINARY, RESEARCH PROGRAM IN IMPLEMENTATION SCIENCE AND PROVIDE A NEEDED RESOURCE FOR IDEA CENTERS FOR BIOMEDICAL RESEARCH EXCELLENCE NATIONALLY TO FOSTER NATIONAL COLLABORATION AND ACCELERATE NIH FUNDING INDEPENDENCE.

CENTER FOR MOLECULAR EPIDEMIOLOGY - ABSTRACT THE FIELD OF EPIDEMIOLOGY HAS GAINED INCREASING PROMINENCE IN THE RESEARCH COMMUNITY AND BECAME A HOUSEHOLD WORD IN 2020. EPIDEMIOLOGY PROVIDES THE TOOLS TO UNCOVER THE UNDERLYING CAUSES OF HUMAN ILLNESS AND TO, IN TURN, INFORM CLINICAL PRACTICE AND PREVENTIVE STRATEGIES, ADVISE POLICY AND REGULATORY ACTIONS, AND MOVE SCIENTIFIC ADVANCEMENTS FORWARD. IN PHASES I AND II, OUR CENTERS OF BIOMEDICAL RESEARCH EXCELLENCE (COBRE) CENTER FOR MOLECULAR EPIDEMIOLOGY AT DARTMOUTH HAS EFFECTIVELY ADVANCED RESEARCH IN THE FIELD. AS THE ONLY CENTER FOR MOLECULAR EPIDEMIOLOGY IN NORTHERN NEW ENGLAND AND ONE OF THE ONLY COBRE PROGRAMS WITH THIS FOCUS NATIONALLY, WE HAVE SUCCESSFULLY RECRUITED AND MENTORED THE NEXT GENERATION OF INDEPENDENT EARLY CAREER INVESTIGATORS. WE FURTHER SUPPORTED ESTABLISHED INVESTIGATORS TO ENLARGE THEIR RESEARCH PROGRAMS, FORM NEW COLLABORATIONS AND INTEGRATE THE LATEST BIOMEDICAL DISCOVERIES, INNOVATIONS, AND METHODS. IN DOING SO, WE DRAMATICALLY GREW OUR RESEARCH PRODUCTIVITY AND GRANT PORTFOLIO, AS EVIDENCED BY THE STEEP RISE IN THE NUMBER OF PUBLICATIONS, PRESENTATIONS, AND GRANTS AWARDED SINCE THE INCEPTION OF OUR COBRE CENTER. AS PART OF ACHIEVING SUSTAINABILITY, WE FORMED A NEW DEPARTMENT OF EPIDEMIOLOGY AND DEVELOPED INNOVATIVE CROSS- DISCIPLINARY TRAINING GRANTS. OUR COHESIVE CENTER BRINGS TOGETHER TALENTED INVESTIGATORS FOCUSING ON 1) APPLYING NEW SCIENTIFIC DISCOVERIES AND TECHNOLOGIES TO ADDRESS MAJOR HUMAN HEALTH CONCERNS, 2) IDENTIFYING EARLY INDICATORS OF DISEASE PATHOGENESIS, AND 3) EXPLORING COMMON PATHWAYS OF DISEASE ETIOLOGY AND PROGRESSION IN HUMAN POPULATIONS, INCLUDING THOSE RELATED TO HEALTH INEQUITIES. IN THIS PHASE III APPLICATION, WE WILL PROGRESS OUR MOLECULAR EPIDEMIOLOGY RESEARCH INFRASTRUCTURE FORWARD TO FULL INDEPENDENCE AND SUSTAINABILITY. SPECIFICALLY, WE WILL 1) EVOLVE A STATE-OF-THE-ART BIOREPOSITORY AND BIOSPECIMEN RESOURCE FACILITY CORE THAT SUPPLIES THE CRITICAL SERVICES RESPONSIVE TO THE ONGOING AND FUTURE NEEDS OF BIOMEDICAL SCIENTISTS, 2) EXPAND THE PIPELINE OF TALENTED, DIVERSE MOLECULAR EPIDEMIOLOGISTS, AND PROVIDE THE REQUISITE MENTORSHIP, CAREER DEVELOPMENT, AND RESEARCH RESOURCES TO CULTIVATE CUTTING-EDGE RESEARCH AND MAKE INVESTIGATORS COMPETITIVE FOR NIH FUNDING, AND 3) ENHANCE THE GOVERNANCE STRUCTURE, IMPLEMENTATION APPROACHES, STAKEHOLDER ENGAGEMENT, AND EVALUATION THAT WILL STRENGTHEN OUR CENTER’S IMPACT, PROMOTE ITS STRATEGIC VISION, AND FORGE TIES WITH REGIONAL AND NATIONAL PARTNERS. OUR SUCCESS IN PHASES I AND II, COMBINED WITH STRONG INSTITUTIONAL SUPPORT, POSITIONS US TO SERVE AS A VITAL RESOURCE IN MOLECULAR EPIDEMIOLOGY FOR NORTHERN NEW ENGLAND, FOR COBRE AND IDEA NETWORKS OF BIOMEDICAL RESEARCH EXCELLENCE (INBRE) PROGRAMS, AND MORE BROADLY.

IMPROVE AKI: A CLUSTER-RANDOMIZED TRIAL OF TEAM-BASED COACHING INTERVENTIONS TO IMPROVE ACUTE KIDNEY INJURY

MECHANISMS OF PHOSPHORYLATION SIGNALING BY PHOSPHOPROTEIN PHOSPHATASES

THE INTENSITY OF ENERGETIC PARTICLES TRAPPED IN EARTH'S RADIATION BELTS VARIES BY ORDERS OF MAGNITUDE ON TIMESCALES FROM MINUTES TO DAYS. THIS DYNAMIC VARIABILITY IS CONTROLLED BY A SHIFTING BALANCE BETWEEN DIFFERENT ACCELERATION AND LOSS MECHANISMS. PRECIPITATION INTO THE ATMOSPHERE HAS BEEN RECOGNIZED FOR DECADES AS A MAJOR LOSS MECHANISM YET CRITICAL QUESTIONS ABOUT THE PHYSICAL PROCESSES REMAIN. SIGNIFICANT PROGRESS HAS BEEN MADE IN IDENTIFYING THE PLASMA WAVES THAT DRIVE ATMOSPHERIC PRECIPITATION [E.G. THORNE 2010 FOR REVIEW]. HOWEVER THE PHYSICAL "MODES" IN WHICH THESE ACT IS NOT WELL SPECIFIED: ELECTRONS MAY BE SCATTERED SLOWLY THROUGH A DIFFUSIVE PROCESS [E.G. SHPRITS ET AL. 2008 REVIEW] OR RAPIDLY THROUGH NONLINEAR PROCESSES [E.G. ALBERT 2000; BORTNIK ET AL. 2008 OMURA ET AL. 2015]. THE PHYSICAL MODE DETERMINES THE SCATTERING RATE AND THUS THE IMPACT ON THE RADIATION BELTS. THEREFORE IT IS IMPORTANT TO ESTABLISH WHERE AND HOW FREQUENTLY LOSS MECHANISMS ACT IN DIFFERENT MODES FOR PARTICLES OF DIFFERENT ENERGIES. THE RELATIVISTIC ELECTRON ATMOSPHERIC LOSS (REAL) CUBESAT MISSION WILL CHARACTERIZE DIFFERENT MODES OF ATMOSPHERIC LOSS BY MAKING HIGH TIME RESOLUTION MEASUREMENTS OF THE ELECTRON PITCH ANGLE AND ENERGY DISTRIBUTIONS IN LOW EARTH ORBIT (LEO) OVER A WIDE ENERGY RANGE FROM KEV TO MEV. LEO IS IDEAL FOR MEASURING PRECIPITATION SINCE THE ATMOSPHERIC LOSS CONE IS LARGER (~60 DEG) THAN AT THE EQUATOR (FEW DEGREES). THE OVERARCHING GOAL OF REAL IS TO IMPROVE OUR UNDERSTANDING OF THE PHYSICAL MECHANISMS RESPONSIBLE FOR SCATTERING RADIATION BELT ELECTRONS INTO THE ATMOSPHERE. REAL WILL INVESTIGATE SPECIFIC ASPECTS OF THESE MECHANISMS BY ANSWERING THE FOLLOWING SCIENCE QUESTIONS: 1.) WHEN AND WHERE DO DIFFERENT PRECIPITATION LOSS MODES (DIFFUSION STRONG DIFFUSION AND NONLINEAR SCATTERING) OCCUR 2.) HOW DO ELECTRON PRECIPITATION LOSS MODES DEPEND ON ENERGY 3.) WHAT IS THE RELATIVE IMPACT OF DIFFERENT PRECIPITATION LOSS MODES ON THE RADIATION BELTS REAL CONTRIBUTES TO THE HELIOPHYSICS OBJECTIVE TO "UNDERSTAND THE SUN AND ITS INTERACTIONS WITH EARTH AND THE SOLAR SYSTEM INCLUDING SPACE WEATHER" BY INVESTIGATING ELECTRON LOSS MECHANISMS IN THE MAGNETOSPHERE. REAL ADDRESSES TWO HELIOPHYSICS SCIENCE GOALS "EXPLORE THE PHYSICAL PROCESSES IN THE SPACE ENVIRONMENT FROM THE SUN TO THE EARTH AND THROUGHOUT THE SOLAR SYSTEM" AND "DEVELOP THE KNOWLEDGE AND CAPABILITY TO DETECT AND PREDICT EXTREME CONDITIONS IN SPACE TO PROTECT LIFE AND SOCIETY AND TO SAFEGUARD HUMAN AND ROBOTIC EXPLORERS BEYOND EARTH" BY IMPROVING OUR UNDERSTANDING OF WAVE-PARTICLE INTERACTIONS IN SPACE PLASMAS LEADING TO IMPROVED PREDICTIVE MODELS OF THE RADIATION BELTS.

MODULAR SOCIAL INTELLIGENCE FOR TEAMING AND COALITION ADAPTATION OF HETEROGENOUS AUTONOMOUS COOPERATIVE AGENTS (ACAS) TOPIC#6

HEALTH PROMOTION AND DISEASE PREVENTION RESEARCH CENTER

ESSENTIAL EFFECTORS OF MYC FUNCTION

CONGRESSIONALLY MANDATED FUNDING FOR DARTMOUTH COLLEGE

DYNAMIC BRAIN REPRESENTATIONS UNDERLYING EMOTIONAL EXPERIENCE

CONNECTIVITY AND FUNCTION OF THE ASYMMETRIC HABENULO-INTERPEDUNCULAR PATHWAY

TISSUE RESIDENT MEMORY T CELL RESPONSES TO CANCER

CHILDREN'S ENVIRONMENTAL HEALTH & DISEASE PREVENTION RESEARCH CENTER AT DARTMOUTH

TRAINING IN THE SCIENCE OF CO-OCCURRING DISORDERS

CDIGMP REGULATION OF BIOFILM FORMATION

CENTER FOR MOLECULAR, CELLULAR, AND TRANSLATIONAL IMMUNOLOGY

MECHANISMS OF COPII-DEPENDENT TRANSPORT

REGULATION OF SISTER-CHROMATID COHESION IN DROSOPHILA

MECHANISMS IN COPII-DEPENDENT TRANSPORT

EVOLUTION OF ASPERGILLUS FUMIGATUS VIRULENCE

GENETIC AND MOLECULAR DISSECTION OF WNT PATHWAY ACTIVATION SUPPLEMENT

CLASS II DIRECTED CARBOMETALATION PROCESSES FOR HETEROCYCLE SYNTHESIS

VARIATIONS IN COLONOSCOPY SCREENING: A POPULATION BASED STUDY

LOW BACK: A MULTI-CENTER CLINICAL TRIAL

TECHNOLOGY DIFFUSION, HEALTH OUTCOMES, AND HEALTHCARE EXPENDITURES

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) -THE NATIONAL SCIENCE FOUNDATION (NSF) GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) IS A HIGHLY COMPETITIVE, FEDERAL FELLOWSHIP PROGRAM. GRFP HELPS ENSURE THE VITALITY AND DIVERSITY OF THE SCIENTIFIC AND ENGINEERING WORKFORCE OF THE UNITED STATES. THE PROGRAM RECOGNIZES AND SUPPORTS OUTSTANDING GRADUATE STUDENTS WHO ARE PURSUING RESEARCH-BASED MASTER'S AND DOCTORAL DEGREES IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) AND IN STEM EDUCATION. THE GRFP PROVIDES THREE YEARS OF FINANCIAL SUPPORT FOR THE GRADUATE EDUCATION OF INDIVIDUALS WHO HAVE DEMONSTRATED THEIR POTENTIAL FOR SIGNIFICANT RESEARCH ACHIEVEMENTS IN STEM AND STEM EDUCATION. THIS AWARD SUPPORTS THE NSF GRADUATE FELLOWS PURSUING GRADUATE EDUCATION AT THIS GRFP INSTITUTION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

A GENOMEWIDE STUDY OF LUNG CANCER IN NEVER SMOKERS

ALTERNATIVE BREAST CANCER IMAGING MODALITIES

THE ROLE OF FAMILY FUNCTIONING AND RACE/ETHNICITY ON THE EFFICACY OF AN OPIOID MISUSE PREVENTION VIDEOGAME INTERVENTION FOR ADOLESCENTS - OPIOID MISUSE FREQUENTLY STARTS IN ADOLESCENCE. IN 2018, AN ESTIMATED 699,000 ADOLESCENTS AGED 12-17 AND 1.9 MILLION YOUNG ADULTS AGED 18-25 MISUSED OPIOIDS IN THE PAST YEAR. AS SUCH, ADOLESCENCE IS THE TIME TO INTERVENE WITH PREVENTION INTERVENTIONS. HOWEVER, FEW INTERVENTIONS EXIST THAT PREVENT INITIATION OF OPIOID MISUSE. DIGITAL INTERVENTIONS SUCH AS SERIOUS VIDEOGAMES CAN IMPROVE HEALTH BEHAVIORS AND ARE ACCESSIBLE BY ADOLESCENTS. ALTHOUGH DIGITAL INTERVENTIONS ARE FEASIBLE AND EFFECTIVE, THIS FINDING IS NOT UNIVERSAL ACROSS ADOLESCENT GROUPS AND THE FACTORS THAT FACILITATE OR HINDER THEIR EFFICACY ARE UNCLEAR. THIS PROPOSAL WILL STUDY FACTORS THAT MAY ACT AS FACILITATORS OR BARRIERS TO THE EFFICACY OF DIGITAL INTERVENTIONS BY STUDYING THE EFFECTS OF FAMILY FUNCTIONING AND RACE/ETHNICITY ON HOW ADOLESCENTS RESPOND TO PLAYSMART, A NOVEL DIGITAL VIDEOGAME INTERVENTION DEVELOPED TO PREVENT THE INITIATION OF OPIOID MISUSE. FAMILY FUNCTIONING, WHICH DESCRIBES ASPECTS OF THE RELATIONSHIP BETWEEN PARENT AND ADOLESCENT, AND RACE/ETHNICITY HAVE BEEN LINKED TO OPIOID MISUSE AND MAY INFLUENCE THE RESPONSE TO PREVENTION INTERVENTIONS. SPECIFIC FAMILY FUNCTIONING FACTORS INCLUDE: PARENT- ADOLESCENT CONFLICT, FAMILY COHESION, PARENT-ADOLESCENT CONNECTION, PARENT-ADOLESCENT COMMUNICATION, PARENTAL MONITORING AND FAMILY SUPPORT OF ADOLESCENTS. ADOLESCENTS FROM DIFFERENT RACIAL/ETHNIC GROUPS HAVE DIFFERENT RISK AND PROTECTIVE FACTORS FOR THE DEVELOPMENT OF OPIOID MISUSE AND THE WAY ADOLESCENTS RESPOND TO PROGRAMS TO PREVENT SUBSTANCE USE MAY BE DIFFERENT BASED ON THEIR RACE/ETHNICITY. HOWEVER, STUDIES EXAMINING THE EFFECT OF FAMILY FUNCTIONING AND RACE/ETHNICITY ON THE RESPONSE TO DIGITAL INTERVENTIONS TO PREVENT OPIOID MISUSE ARE LACKING. THE SPECIFIC AIMS OF THIS DIVERSITY SUPPLEMENT PROPOSAL ARE: 1) TO ASSESS IF ADOLESCENT REPORT OF FAMILY FUNCTIONING (A) MODIFIES THE EFFECT OF PLAYSMART IN REDUCING RISK FACTORS FOR OPIOID MISUSE (PERCEPTION OF GREAT RISK OF HARM FROM OPIOID MISUSE, INTENTIONS TO MISUSE OPIOIDS, SELF-EFFICACY FOR REFUSING OPIOIDS) AND (B) INFLUENCES THE LEVEL OF GAME ENGAGEMENT; 2) TO ASSESS IF THE EFFECT OF PLAYSMART IN REDUCING RISK FACTORS FOR OPIOID MISUSE DIFFERS BY ADOLESCENT RACE/ETHNICITY; AND 3) TO EXPLORE IF DIFFERENCES IN HOW ADOLESCENTS AND THEIR PARENTS PERCEIVE FAMILY FUNCTIONING AFFECTS PLAYSMART OUTCOMES. WE HYPOTHESIZE THAT: 1) PARTICIPANTS WITH HIGH BASELINE SCORES OF FAMILY FUNCTIONING IN THE PLAYSMART GROUP WILL HAVE BETTER OUTCOMES AT THREE MONTHS POST- RANDOMIZATION COMPARED TO PARTICIPANTS WITH LOW SCORES OF FAMILY FUNCTIONING IN THE PLAYSMART GROUP AND COMPARED WITH PARTICIPANTS IN THE CONTROL GROUP; AND 2) NON-HISPANIC WHITE ADOLESCENTS WILL HAVE BETTER OUTCOMES AT THREE MONTHS POST-RANDOMIZATION COMPARED TO BLACK AND HISPANIC ADOLESCENTS. FINDINGS FROM THIS PROPOSAL WILL ADVANCE OUR UNDERSTANDING OF FACTORS THAT IMPACT DIGITAL PREVENTION PROGRAMS TARGETING OPIOID MISUSE AND INFORM NOVEL STRATEGIES TO IMPROVE THE EFFICACY OF DIGITAL INTERVENTIONS TO PREVENT NEGATIVE HEALTH OUTCOMES AND PROMOTE ADAPTIVE BEHAVIORS ACROSS A DIVERSE POPULATION OF ADOLESCENTS.

HOST-MICROBE INTERACTIONS

MOLECULAR AND CELLULAR BIOLOGY AT DARTMOUTH

TOPIC(009) WEARABLE HEALTH AND HAZARD BIOSENSOR TECHNOLOGY FOR THE WARFIGHTER

PIP3-INDEPENDENT REGULATION OF AKT1 ACTIVITY IN T CELLS

MAPPING THE GENOME OF COHERENT QUANTUM DEFECTS FOR QUANTUM INFORMATION SCIENCE

TWC: FRONTIER: COLLABORATIVE: ENABLING TRUSTWORTHY CYBERSYSTEMS FOR HEALTH AND WELLNESS

THE MAIN GOAL OF THIS CENTER IS TO FILL CRITICAL KNOWLEDGE GAPS IN THE ROLE OF ARSENIC (AS) IN DRINKING WATER AND FOOD TO CHILD GROWTH, DEVELOPMENT A

TIMING AND REGULATION OF MEIOTIC COMMITMENT IN S CEREVISIAE

VISTA IS A NEGATIVE CHECKPOINT REGULATOR OF INNATE IMMUNITY