North Carolina State University

POWERAMERICA: THE NEXT GENERATION POWER ELECTRONICS MANUFACTURING INNOVATION INSTITUTE

2ND EMERGENCY RELIEF FUND

NORTH CAROLINA TRANSLATIONAL & CLINICAL SCIENCES INSTITUTE (NC TRACS)

EMERGENCY RELIEF FUND

IR-4 MINOR CROP PEST MANAGEMENT

NSF NANOSYSTEMS ENGINEERING RESEARCH CENTER FOR ADVANCED SELF-POWERED SYSTEMS OF INTEGRATED SENSORS AND TECHNOLOGIES (ASSIST)

NSF ENGINEERING RESEARCH CENTER FOR FUTURE RENEWABLE ELECTRIC ENERGY DELIVERY AND MANAGEMENT (FREEDM) SYSTEMS

COLORECTAL CHEMOPREVENTION WITH CALCIUM AND VITAMIN D

ASSOCIATE AWARD FOR MEASURE EVALUATION PROJECT.

STC: SCIENCE AND TECHNOLOGIES FOR PHOSPHORUS SUSTAINABILITY (STEPS) CENTER

CONSORTIUM FOR NONPROLIFERATION- ENABLING CAPABILITIES (PDP14-04)

ENVIRONMENTAL EXPOSURE AND EFFECT OF HAZARDOUS CHEMICALS

AI INSTITUTE FOR ENGAGED LEARNING

NORTH CAROLINA STATE UNIVERSITY-MEP CENTER FOR STATE OF NORTH CAROLINA

CENTER FOR HUMAN HEALTH AND THE ENVIRONMENT

NUCLEAR STRUCTURE RESEARCH AT THE TRIANGLE UNIVERSITIES NUCLEAR LABORATORY

NORTH CAROLINA STATE UNIVERSITY - MEP CENTER FOR STATE OF NORTH CAROLINA

CATEGORY 1: UNC CENTER FOR HEALTH PROMOTION AND DISEASE PREVENTION

POWERAMERICA: A WIDE BANDGAP SEMICONDUCTOR MANUFACTURING INSTITUTE

FUNCTIONAL SELECTIVITY: A NOVEL APPROACH FOR CNS DRUG DISCOVERY

THE IR-4 PROJECT FACILITATES REGISTRATION OF CROP PROTECTION TECHNOLOGY FOR SPECIALTY CROPS (FRUITS, VEGETABLES, NUTS, HERBS, ORNAMENTALS, OTHER HORTICULTURE CROPS) AND MINOR USES ON MAJOR CROPS (CORN, SOYBEAN, WHEAT, ETC.) TO MANAGE INSECT, PLANT DISEASE, WEED, AND OTHER DESTRUCTIVE PESTS. IR-4 ACCOMPLISHES ITS MISSION BY DEVELOPING THE DATA REQUIRED BY THE US ENVIRONMENTAL PROTECTION AGENCY, THE STATES, AND INDUSTRY TO EXPAND REGISTRATIONS WITH CONVENTIONAL PESTICIDES AND BIOPESTICIDES. IR-4 SUPPLEMENTS THE EFFORTS OF INDUSTRY IN MARKETS THAT LACK ADEQUATE SALES TO SUPPORT THEIR DEVELOPMENT INVESTMENT. IR-4 PROVIDES SIGNIFICANT DELIVERABLES WITH POSITIVE IMPACTS TO STAKEHOLDERS THAT INCLUDE NEW REGISTRATIONS FOR KEY PESTS; EXTENDING REGISTRATIONS TO INCLUDE SIMILAR CROPS THROUGH CROP GROUPING/DATA EXTRAPOLATION; AND ASSISTING IN THE HARMONIZATION OF INTERNATIONAL MAXIMUM RESIDUE LEVELS TO REMOVE PESTICIDE RESIDUES IN CROPS AS A TRADE BARRIER. IR-4 CONCENTRATES ITS EFFORTS ON LOWER RISK TECHNOLOGY THAT RESPECTS HUMAN HEALTH AND THE ENVIRONMENT. THIS GIVES THE SPECIALTY CROP FARMERS/GROWERS ACCESS TO CROP PROTECTION TECHNOLOGY TO BETTER MANAGE PESTS IN A SUSTAINABLE AND ENVIRONMENTALLY FRIENDLY MANNER. ORGANIC GROWERS ALSO BENEFIT FROM REGISTRATIONS OF BIOPESTICIDES DERIVED FROM NATURAL MATERIALS.IR-4 HEADQUARTERS (HQ), A UNIT OF NC STATE UNIVERSITY, MANAGES/COORDINATES ACTIVITIES FOR THE NATIONAL IR-4 PROJECT. HQ COORDINATES RESEARCH ACTIVITIES WITH COLLABORATIONS WITH THE FOUR IR-4 REGIONAL CENTERS (NE-UNIVERSITY OF MARYLAND EASTERN SHORE; NC-MICHIGAN STATE UNIVERSITY, SR-UNIVERSITY OF FLORIDA, AND WR-UNIVERSITY OF CALIFORNIA-DAVIS), USDA-ARS, IR-4'S FIELD RESEARCH FARMS, COMMODITY/GROWER GROUPS, THE CROP PROTECTION INDUSTRY, STATE AGRICULTURAL EXPERIMENT STATIONS, EPA, AND FOREIGN GOVERNMENTS.

PROJECT ABSTRACT OUR PORTFOLIOS OF SOLUTIONDRIVEN, CUTTINGEDGE RESEARCH IS CREATING NEW KNOWLEDGE AND TECHNOLOGY WHICH IS THEN EXTENDED TO ALL NORTH CAROLINIANS THROUGH NC COOPERATIVE EXTENSION. WE ARE TRANSFORMING SCIENCE INTO EVERYDAY SOLUTIONS THAT IMPROVE LIVES AND ALLOW NORTH CAROLINIANS TO LEAD PROSPEROUS, HEALTHY LIVES. A STATEWIDE NETWORK OF EXTENSION AGENTS SERVES AS THE CONDUIT THROUGH WHICH THE NEEDS OF THE COMMUNITY ARE COMMUNICATED TO UNIVERSITY RESEARCHERS WHO THEN CONDUCT RESEARCH AND FORMULATE SOLUTIONS. EXTENSION AGENTS THEN DELIVER ESSENTIAL INFORMATION INTO THE HANDS OF GROWERS, INDUSTRY, AND MEMBERS OF THE COMMUNITY. RESEARCH AND EXTENSION EFFORTS AT NC STATE FOCUS ON ADDRESSING FOUR IDENTIFIED STATEWIDE CRITICAL ISSUES: IMPROVING PLANT AND ANIMAL AGRICULTURAL SYSTEMS; PROTECTING ENVIRONMENTAL RESOURCES, ENRICHING YOUTH, FAMILY AND COMMUNITY WELLBEING; AND ENHANCING FOOD SAFETY, NUTRITION AND HEALTH. THROUGH INTEGRATED RESEARCH AND EXTENSION PROGRAMS, NC STATE IS SOLVING CHALLENGES RELATED TO THE PRODUCTIVITY AND PROFITABILITY OF BOTH LARGE AND SMALL SCALE FARMS. RESEARCHERS AND EXTENSION EDUCATORS ARE ALSO DEVELOPING AND DISSEMINATING KNOWLEDGE AND TECHNOLOGY TO IMPROVE LANDSCAPING AND GARDENING. RESEARCH AND EXTENSION PROGRAMS IN ANIMAL SYSTEMS ARE FOCUSED ON DEVELOPING AND DISSEMINATING KNOWLEDGE AND METHODS FOR ANIMAL BREEDING, REPRODUCTION, NUTRITION, GENETICS AND GENOMICS, PHYSIOLOGY, ENVIRONMENTAL STRESS, PRODUCT QUALITY, AND HEALTH AND WELLBEING. THESE INTEGRATED RESEARCH AND EXTENSION EFFORTS ALSO AIM TO TACKLE THE CRITICAL ISSUES IMPACTING THE QUALITY OF OUR SOIL, WATER AND AIR BY PROVIDING SCIENTIFIC SOLUTIONS FOR ANIMAL WASTE MANAGEMENT, WASTEWATER TREATMENT, NUTRIENT MANAGEMENT, SEPTIC SYSTEMS, WETLAND MANAGEMENT, SOIL PROPERTIES, AND FISHERY AND POND MANAGEMENT. NC STATE EXTENSION CONTINUES TO PROVIDE OPPORTUNITIES TO ENRICH YOUTH, FAMILY AND COMMUNITY WELL BEING THROUGH THE 4H YOUTH DEVELOPMENT PROGRAM. 4H PROGRAMS INCREASE OPPORTUNITIES FOR YOUTH TO DEVELOP LIFE SKILLS, GROW CONFIDENCE, INDEPENDENCE, RESILIENCE, AND STEM SKILLS THROUGH FUN HANDS ON LEARNING IN SAFE, HEALTHY, AND ENRICHING ENVIRONMENTS. EXTENSION PROGRAMS ALSO ADDRESS CRITICAL CHALLENGES AFFECTING CONSUMER AND FAMILY WELLBEING. IN ADDITION TO YOUTH DEVELOPMENT, OTHER FOCUS AREAS INCLUDE PARENTING, CHILDCARE, FAMILY RELATIONSHIPS, FINANCIAL MANAGEMENT, AGING, HEALTHY HOMES, AND DISASTER READINESS, RESPONSE, AND RECOVERY. AT THE COMMUNITY LEVEL, EXTENSION WORKS WITH INDIVIDUALS, COMMUNITY GROUPS AND LOCAL GOVERNMENTS ON LEADERSHIP SKILLS, WORKFORCE DEVELOPMENT, ENTREPRENEURSHIP, CIVIC ENGAGEMENT, VOLUNTEERISM, COMMUNITY PLANNING, AND DISASTER PREPAREDNESS NC STATES RESEARCH AND EXTENSION EFFORTS TO ENHANCE FOOD SAFETY, NUTRITION AND HEALTH AND TO KEEP AMERICANS HEALTHY AND FREE FROM FOODBORNE ILLNESS NECESSITATE A FOCUS ON PREVENTING FOOD SAFETY PROBLEMS RATHER THAN TAKING A REACTIONARY APPROACH. NC STATES INTEGRATED RESEARCH AND EXTENSION EFFORTS FOCUS ON PROTECTING THE SAFETY OF FOODS ALONG THE ENTIRE SUPPLY CHAIN, FROM PRODUCTION TO CONSUMPTION. TO MEET THE GROWING NEED FOR HEALTHY FOOD, RESEARCHERS ARE DEVELOPING AND PRODUCING NEW FOOD PRODUCTS THAT PROMOTE HEALTH AND PREVENT DISEASE. AT THE SAME TIME, EXTENSION PROVIDES NUTRITION EDUCATION PROGRAMMING TO ENSURE THAT INDIVIDUALS, FAMILIES, AND COMMUNITIES HAVE THE KNOWLEDGE THEY NEED TO MAKE INFORMED CHOICES ABOUT FOOD AND HEALTHY LIFESTYLES. IMPROVING PLANT AND ANIMAL AGRICULTURAL SYSTEMS: WITHIN THIS AREA, WE WILL WORK TO ADDRESS CROSSCUTTING AND EMERGING ISSUES OF ANIMAL AND PLANT HEALTH AND PRODUCTION. IN ANIMAL SYSTEM, RESEARCHERS WILL STUDY THE EFFICIENCY OF DIFFERENT FEEDING SOURCES TO IMPROVE ANIMAL PRODUCTIVITY AND GUT HEALTH. IN PLANT SYSTEMS, THE FOCUS WILL BE IN SUSTAINABLE AGRICULTURE, ALTERNATIVE AND HIGH VALUE CROP PRODUCTION, SEASON EXTENSION, CLIMATE CHANGE ADAPTATION, VALUE ADDED AGRICULTURE, DIGITAL AGRICULTURE, SOIL HEALTH, PEST CONTROL, AND AGRO ECONOMICS. EXTENSION WILL CONTINUE TO EXPAND ITS WORK WITH LIVESTOCK PRODUCERS, PLACING SPECIAL EMPHASIS ON LIMITED RESOURCES, SMALL SCALE MINORITY FARMERS. THE FARM PAVILION WILL FOCUS ON SUSTAINABLE AGRICULTURE AND LOCAL AND COMMUNITY FOOD SYSTEMS, HOUSING ITS APPLIED RESEARCH AND DEMONSTRATION PROGRAMS STAFF AND PROVIDING SPACE FOR MEETINGS, FORUMS AND CONFERENCES. ENHANCING FOOD SAFETY, NUTRITION AND HEALTH: WITHIN THIS AREA BOTH RESEARCH AND EXTENSION WILL WORK TO ADDRESS THE ISSUE OF HUMAN HEALTH, FOOD SAFETY AND HEALTHY LIVING HABITS. THE RESEARCH WILL FOCUS ON WHOLE GRAIN CEREALS, HUMAN HEALTH AND HUMAN NUTRITION, PROBIOTICS STRAINS, FOOD ALLERGY, FOOD PRODUCTION PROCESS, BIOACTIVE COMPOUNDS OF FOOD, POSTHARVEST TECHNOLOGY AND FOOD SECURITY. COOPERATIVE EXTENSION AND RESEARCHERS AT NCA<(>&<)>T WILL WORK TOGETHER IN A CONCERTED EFFORT TO INCREASE INFORMATION AND RESOURCES FOR AFRICAN AMERICAN FAMILIES AND CHILDREN IN RURAL COMMUNITIES WHO ARE OFTEN POOR AND DISPROPORNANCIALLY VULNERABLE ARE WELL EQUIPPED TO MAKE SOUND FINANCIAL DECISIONS FOR THEMSELVES AND THEIR FAMILIES. 4-H PROGRAMMING WILL FOCUS ON AREAS SUCH AS STEM (SCIENCE, TECHNOLOGY, ENGINEERING, AND MATH), LEADERSHIP DEVEL OPMENT, AND AGRISCIENCE. INNOVATION STATION, THE CUTTING-EDGE MOBILE LEARNING EXPERIENCE, WILL CONTINUE TRAVELING TO COUNTIES THROUGHOUT NORTH CAROLINA, PROVIDING INTRODUCTORY AND ADVANCED STEM CURRICULA FOR CHILDREN IN GRADES K-12. ENVIRONMENTAL AND NATURAL RESOU RCES: IN THIS AREA WE WILL WORK TO PROTECT THE NATURAL ENVIRONMENT, PROVIDE THE SOLUTION FOR WASTE MANAGEMENT AND CONVENTIONAL ENERGY. CAES RESEARCHERS WILL INVESTIGATE AN ADVANCED BIOLOGICAL SYSTEM TO PRODUCE ALTERNATIVE ENERGY, TREAT THE AGRICULTURAL AND INDUSTRIAL WASTE, AND PROTECT AND IMPROVE WATER QUALITY. CAES RESEARCHERS WILL BE INVOLVED IN MULTISTATE CLIMATE CHANGE PROJECT TO STUDY THE IMPACT OF CLIMATE CHANGE IN SOCIALLY DISADVANTAGED FARMERS AND COMMUNITY OF COLOR. RESEARCHERS WILL BE DEVELOPING THE ADAPTATION AND MITIGATION SOLUTION TO IMPROVE AGRICULTURE AND NATURAL RESOURCES AND WILL BE PROPOSING POLICIES TO ADDRESS THE ISSUE OF ENVIRONMENTAL JUSTICE AND CLIMATE CHANGE. EXTENSION WILL CONTINUE TO SUPPORT SMALL SCALE PRODUCERS AND LANDOWNERS IN THEIR EFFORT TO DEVELOP WOODLOT MANAGEMENT PLANS WHILE ALSO INTEGRATING TECHNIQUES AND PRACTICES SUCH AS SILVOPASTURE PRODUCTION AND RIPARIAN BUFFERS.

THROUGH INTEGRATED RESEARCH AND EXTENSION PROGRAMS, NC STATE IS SOLVING CHALLENGES RELATED TO THE PRODUCTIVITY AND PROFITABILITY OF BOTH LARGE- AND SMALL-SCALE FARMS. RESEARCHERS AND EXTENSION EDUCATORS ARE ALSO DEVELOPING AND DISSEMINATING KNOWLEDGE AND TECHNOLOGY TO IMPROVE LANDSCAPING AND GARDENING. RESEARCH AND EXTENSION PROGRAMS IN ANIMAL SYSTEMS ARE FOCUSED ON DEVELOPING AND DISSEMINATING KNOWLEDGE AND METHODS FOR ANIMAL BREEDING, REPRODUCTION, NUTRITION, GENETICS AND GENOMICS, PHYSIOLOGY, ENVIRONMENTAL STRESS, PRODUCT QUALITY, AND HEALTH AND WELL-BEING. THESE INTEGRATED RESEARCH AND EXTENSION EFFORTS ALSO AIM TO TACKLE THE CRITICAL ISSUES IMPACTING THE QUALITY OF OUR SOIL, WATER AND AIR BY PROVIDING SCIENTIFIC SOLUTIONS FOR ANIMAL WASTE MANAGEMENT, WASTEWATER TREATMENT, NUTRIENT MANAGEMENT, SEPTIC SYSTEMS, WETLAND MANAGEMENT, SOIL PROPERTIES, AND FISHERY AND POND MANAGEMENT. NC STATE'S RESEARCH AND EXTENSION EFFORTS TO ENHANCE FOOD SAFETY, NUTRITION AND HEALTH AND TO KEEP AMERICAN'S HEALTHY AND FREE FROM FOODBORNE ILLNESS NECESSITATE A FOCUS ON PREVENTING FOOD SAFETY PROBLEMS RATHER THAN TAKING A REACTIONARY APPROACH. NC STATE'S INTEGRATED RESEARCH AND EXTENSION EFFORTS FOCUS ON PROTECTING THE SAFETY OF FOODS ALONG THE ENTIRE SUPPLY CHAIN, FROM PRODUCTION TO CONSUMPTION. TO MEET THE GROWING NEED FOR HEALTHY FOOD, RESEARCHERS ARE DEVELOPING AND PRODUCING NEW FOOD PRODUCTS THAT PROMOTE HEALTH AND PREVENT DISEASE. AT THE SAME TIME, EXTENSION PROVIDES NUTRITION EDUCATION PROGRAMMING TO ENSURE THAT INDIVIDUALS, FAMILIES, AND COMMUNITIES HAVE THE KNOWLEDGE THEY NEED TO MAKE INFORMED CHOICES ABOUT FOOD AND HEALTHY LIFESTYLES. IMPROVING PLANT AND ANIMAL AGRICULTURAL SYSTEMS: WITHIN THIS AREA, WE WILL WORK TO ADDRESS CROSS-CUTTING AND EMERGING ISSUES OF ANIMAL AND PLANT HEALTH AND PRODUCTION. IN ANIMAL SYSTEMS, RESEARCHERS WILL STUDY THE EFFICIENCY OF DIFFERENT FEEDING SOURCES TO IMPROVE ANIMAL PRODUCTIVITY AND GUT HEALTH. IN PLANT SYSTEMS, THE FOCUS WILL BE IN SUSTAINABLE AGRICULTURE, ALTERNATIVE AND HIGH VALUE CROP PRODUCTION, SEASON EXTENSION, CLIMATE CHANGE ADAPTATION, VALUE ADDED AGRICULTURE, DIGITAL AGRICULTURE, SOIL HEALTH, PEST CONTROL, AND AGRO ECONOMICS. EXTENSION WILL CONTINUE TO EXPAND ITS WORK WITH LIVESTOCK PRODUCERS, PLACING SPECIAL EMPHASIS ON LIMITED RESOURCES, SMALL- SCALE MINORITY FARMERS. THE FARM PAVILION WILL FOCUS ON SUSTAINABLE AGRICULTURE AND LOCAL AND COMMUNITY FOOD SYSTEMS, HOUSING ITS APPLIED RESEARCH AND DEMONSTRATION PROGRAMS' STAFF AND PROVIDING SPACE FOR MEETINGS, FORUMS AND CONFERENCES.

THROUGH INTEGRATED RESEARCH AND EXTENSION PROGRAMS, NC STATE IS SOLVING CHALLENGES RELATED TO THE PRODUCTIVITY AND PROFITABILITY OF BOTH LARGE- AND SMALL-SCALE FARMS. RESEARCHERS AND EXTENSION EDUCATORS ARE ALSO DEVELOPING AND DISSEMINATING KNOWLEDGE AND TECHNOLOGY TO IMPROVE LANDSCAPING AND GARDENING. RESEARCH AND EXTENSION PROGRAMS IN ANIMAL SYSTEMS ARE FOCUSED ON DEVELOPING AND DISSEMINATING KNOWLEDGE AND METHODS FOR ANIMAL BREEDING, REPRODUCTION, NUTRITION, GENETICS AND GENOMICS, PHYSIOLOGY, ENVIRONMENTAL STRESS, PRODUCT QUALITY, AND HEALTH AND WELL-BEING. THESE INTEGRATED RESEARCH AND EXTENSION EFFORTS ALSO AIM TO TACKLE THE CRITICAL ISSUES IMPACTING THE QUALITY OF OUR SOIL, WATER AND AIR BY PROVIDING SCIENTIFIC SOLUTIONS FOR ANIMAL WASTE MANAGEMENT, WASTEWATER TREATMENT, NUTRIENT MANAGEMENT, SEPTIC SYSTEMS, WETLAND MANAGEMENT, SOIL PROPERTIES, AND FISHERY AND POND MANAGEMENT. NC STATE'S RESEARCH AND EXTENSION EFFORTS TO ENHANCE FOOD SAFETY, NUTRITION AND HEALTH AND TO KEEP AMERICAN'S HEALTHY AND FREE FROM FOODBORNE ILLNESS NECESSITATE A FOCUS ON PREVENTING FOOD SAFETY PROBLEMS RATHER THAN TAKING A REACTIONARY APPROACH. NC STATE'S INTEGRATED RESEARCH AND EXTENSION EFFORTS FOCUS ON PROTECTING THE SAFETY OF FOODS ALONG THE ENTIRE SUPPLY CHAIN, FROM PRODUCTION TO CONSUMPTION. TO MEET THE GROWING NEED FOR HEALTHY FOOD, RESEARCHERS ARE DEVELOPING AND PRODUCING NEW FOOD PRODUCTS THAT PROMOTE HEALTH AND PREVENT DISEASE. AT THE SAME TIME, EXTENSION PROVIDES NUTRITION EDUCATION PROGRAMMING TO ENSURE THAT INDIVIDUALS, FAMILIES, AND COMMUNITIES HAVE THE KNOWLEDGE THEY NEED TO MAKE INFORMED CHOICES ABOUT FOOD AND HEALTHY LIFESTYLES. IMPROVING PLANT AND ANIMAL AGRICULTURAL SYSTEMS: WITHIN THIS AREA, WE WILL WORK TO ADDRESS CROSS-CUTTING AND EMERGING ISSUES OF ANIMAL AND PLANT HEALTH AND PRODUCTION. IN ANIMAL SYSTEMS, RESEARCHERS WILL STUDY THE EFFICIENCY OF DIFFERENT FEEDING SOURCES TO IMPROVE ANIMAL PRODUCTIVITY AND GUT HEALTH. IN PLANT SYSTEMS, THE FOCUS WILL BE IN SUSTAINABLE AGRICULTURE, ALTERNATIVE AND HIGH VALUE CROP PRODUCTION, SEASON EXTENSION, CLIMATE CHANGE ADAPTATION, VALUE ADDED AGRICULTURE, DIGITAL AGRICULTURE, SOIL HEALTH, PEST CONTROL, AND AGRO ECONOMICS. EXTENSION WILL CONTINUE TO EXPAND ITS WORK WITH LIVESTOCK PRODUCERS, PLACING SPECIAL EMPHASIS ON LIMITED RESOURCES, SMALL- SCALE MINORITY FARMERS. THE FARM PAVILION WILL FOCUS ON SUSTAINABLE AGRICULTURE AND LOCAL AND COMMUNITY FOOD SYSTEMS, HOUSING ITS APPLIED RESEARCH AND DEMONSTRATION PROGRAMS' STAFF AND PROVIDING SPACE FOR MEETINGS, FORUMS AND CONFERENCES.

THROUGH INTEGRATED RESEARCH AND EXTENSION PROGRAMS, NC STATE IS SOLVING CHALLENGES RELATED TO THE PRODUCTIVITY AND PROFITABILITY OF BOTH LARGE- AND SMALL-SCALE FARMS. RESEARCHERS AND EXTENSION EDUCATORS ARE ALSO DEVELOPING AND DISSEMINATING KNOWLEDGE AND TECHNOLOGY TO IMPROVE LANDSCAPING AND GARDENING. RESEARCH AND EXTENSION PROGRAMS IN ANIMAL SYSTEMS ARE FOCUSED ON DEVELOPING AND DISSEMINATING KNOWLEDGE AND METHODS FOR ANIMAL BREEDING, REPRODUCTION, NUTRITION, GENETICS AND GENOMICS, PHYSIOLOGY, ENVIRONMENTAL STRESS, PRODUCT QUALITY, AND HEALTH AND WELL-BEING. THESE INTEGRATED RESEARCH AND EXTENSION EFFORTS ALSO AIM TO TACKLE THE CRITICAL ISSUES IMPACTING THE QUALITY OF OUR SOIL, WATER AND AIR BY PROVIDING SCIENTIFIC SOLUTIONS FOR ANIMAL WASTE MANAGEMENT, WASTEWATER TREATMENT, NUTRIENT MANAGEMENT, SEPTIC SYSTEMS, WETLAND MANAGEMENT, SOIL PROPERTIES, AND FISHERY AND POND MANAGEMENT. NC STATE'S RESEARCH AND EXTENSION EFFORTS TO ENHANCE FOOD SAFETY, NUTRITION AND HEALTH AND TO KEEP AMERICAN'S HEALTHY AND FREE FROM FOODBORNE ILLNESS NECESSITATE A FOCUS ON PREVENTING FOOD SAFETY PROBLEMS RATHER THAN TAKING A REACTIONARY APPROACH. NC STATE'S INTEGRATED RESEARCH AND EXTENSION EFFORTS FOCUS ON PROTECTING THE SAFETY OF FOODS ALONG THE ENTIRE SUPPLY CHAIN, FROM PRODUCTION TO CONSUMPTION. TO MEET THE GROWING NEED FOR HEALTHY FOOD, RESEARCHERS ARE DEVELOPING AND PRODUCING NEW FOOD PRODUCTS THAT PROMOTE HEALTH AND PREVENT DISEASE. AT THE SAME TIME, EXTENSION PROVIDES NUTRITION EDUCATION PROGRAMMING TO ENSURE THAT INDIVIDUALS, FAMILIES, AND COMMUNITIES HAVE THE KNOWLEDGE THEY NEED TO MAKE INFORMED CHOICES ABOUT FOOD AND HEALTHY LIFESTYLES. IMPROVING PLANT AND ANIMAL AGRICULTURAL SYSTEMS: WITHIN THIS AREA, WE WILL WORK TO ADDRESS CROSS-CUTTING AND EMERGING ISSUES OF ANIMAL AND PLANT HEALTH AND PRODUCTION. IN ANIMAL SYSTEMS, RESEARCHERS WILL STUDY THE EFFICIENCY OF DIFFERENT FEEDING SOURCES TO IMPROVE ANIMAL PRODUCTIVITY AND GUT HEALTH. IN PLANT SYSTEMS, THE FOCUS WILL BE IN SUSTAINABLE AGRICULTURE, ALTERNATIVE AND HIGH VALUE CROP PRODUCTION, SEASON EXTENSION, WEATHER ADAPTATION, VALUE ADDED AGRICULTURE, DIGITAL AGRICULTURE, SOIL HEALTH, PEST CONTROL, AND AGRO ECONOMICS. EXTENSION WILL CONTINUE TO EXPAND ITS WORK WITH LIVESTOCK PRODUCERS, PLACING SPECIAL EMPHASIS ON LIMITED RESOURCES, SMALL- SCALE MINORITY FARMERS. THE FARM PAVILION WILL FOCUS ON SUSTAINABLE AGRICULTURE AND LOCAL AND COMMUNITY FOOD SYSTEMS, HOUSING ITS APPLIED RESEARCH AND DEMONSTRATION PROGRAMS' STAFF AND PROVIDING SPACE FOR MEETINGS, FORUMS AND CONFERENCES.

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND GRANT INSTITUTIONS

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND GRANT INSTITUTIONS

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIOS

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS

HISTORICALLY BLACK COLLEGES AND UNIVERSITIES PROGRAM

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE IR-4 PROJECT FACILITATES REGISTRATION OF CROP PROTECTION TECHNOLOGY FOR SPECIALTY CROPS (FRUITS, VEGETABLES, NUTS, HERBS, ORNAMENTALS, OTHER HORTICULTURE CROPS) AND MINOR USES ON MAJOR CROPS (CORN, SOYBEAN, WHEAT, ETC.) TO MANAGE INSECT, PLANT DISEASE, WEED AND OTHER DESTRUCTIVE PESTS. IR-4ACCOMPLISHES ITS MISSION BY DEVELOPING THE DATA REQUIRED BY US ENVIRONMENTAL PROTECTION AGENCY, THE STATES, AND INDUSTRY TO EXPAND REGISTRATIONS WITH CONVENTIONAL PESTICIDES AND BIOPESTICIDES. IR-4 SUPPLEMENTS THE EFFORTS OF INDUSTRY IN MARKETS THAT LACK ADEQUATE SALES TO SUPPORT THEIR DEVELOPMENT INVESTMENT. IR-4 PROVIDES SIGNIFICANT DELIVERABLES WITH POSITIVE IMPACTS TO STAKEHOLDERS THAT INCLUDE NEW REGISTRATIONS FOR KEY PESTS; EXTENDING REGISTRATIONS TO INCLUDE SIMILAR CROPS THROUGH CROP GROUPING/DATA EXTRAPOLATION; AND ASSISTING IN THE HARMONIZATION OF INTERNATIONAL MAXIMUM RESIDUE LEVELS TO REMOVE PESTICIDE RESIDUES IN CROPS AS A TRADE BARRIER. IR-4 CONCENTRATES ITS EFFORTS ON LOWER RISK TECHNOLOGY THAT RESPECTS HUMAN HEALTH AND THE ENVIRONMENT. THIS GIVES THE SPECIALTY CROP FARMERS/GROWERS ACCESS TO CROP PROTECTION TECHNOLOGY TO BETTER MANAGE PESTS IN A SUSTAINABLE AND ENVIRONMENTALLY FRIENDLY MANNER. ORGANIC GROWERS ALSO BENEFIT FROM REGISTRATIONS OF BIOPESTICIDES DERIVED FROM NATURAL MATERIALS.IR-4 HEADQUARTERS (HQ), A UNIT OF NC STATE UNIVERSITY, MANAGES/COORDINATES ACTIVITIES FOR THE NATIONAL IR-4 PROJECT. HQ COORDINATES RESEARCH ACTIVITIES WITH COLLABORATIONS WITH THE FOUR IR-4 REGIONAL CENTERS (NE-UNIVERSITY OF MARYLAND EASTERN SHORE; NC-MICHIGAN STATE UNIVERSITY, SR-UNIVERSITY OF FLORIDA, AND WR-UNIVERSITY OF CALIFORNIA-DAVIS), USDA-ARS, IR-4&#39;S FIELD RESEARCH FARMS, COMMODITY/GROWER GROUPS, THE CROP PROTECTION INDUSTRY, STATE AGRICULTURAL EXPERIMENT STATIONS, EPA, AND FOREIGN GOVERNMENTS.

CENTER FOR GENOMICS AND SOCIETY

NORTH CAROLINA STATE UNIVERSITY

NEUTRALIZING ANTIBODY & AAV FIX GENE THERAPY

HISTORICALLY BLACK COLLEGES AND UNIVERSITIES PROGRAM

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS

PULMONARY SURFACE LIQUID HOMEOSTASIS

NORTH CAROLINA STATE UNIVERSITY

SOUTHERN LIVER HEALTH COHORT - PROJECT SUMMARY/ABSTRACT PRIMARY LIVER CANCER, THE VAST MAJORITY OF WHICH IS HEPATOCELLULAR CARCINOMA (HCC) IS ONE OF THE FEW CANCERS WITH INCREASING INCIDENCE IN THE US. INCIDENCE OF HCC HAS TRIPLED SINCE 1980, WHICH IS PARTICULARLY WORRISOME GIVEN THAT HCC CONFERS A MEDIAN SURVIVAL OF LESS THAN TWO YEARS. THE STEEPEST INCREASES IN INCIDENCE ARE IN SOUTHERN RURAL STATES AND AMONG ETHNIC MINORITIES. WHILE THE PREVALENCE OF HCC HAD PARALLELED HIGH RATES OF VIRAL HEPATITIS IN THE LAST SEVERAL DECADES, RECENT INCREASES IN THE PREVALENCE OF NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) AND ITS PROGRESSION TO NONALCOHOLIC STEATOHEPATITIS (NASH) WITH FIBROSIS AND CIRRHOSIS, HAS FUELED HCC IN RECENT YEARS. YET, THESE FACTORS ALONE DO NOT EXPLAIN THE SUBSTANTIAL REGIONAL AND ETHNIC VARIATION IN HCC PROGRESSION. ONE UNDERSTUDIED BUT POTENTIALLY POTENT HCC RISK FACTOR WITH INCREASING PREVALENCE THAT DISPROPORTIONATELY AFFECTS ETHNIC MINORITIES, IS EXPOSURE TO ENVIRONMENTAL CONTAMINANTS. THESE CONTAMINANTS DEGRADE SLOWLY AND THEREFORE PERSIST IN THE ENVIRONMENT, PROVIDING A STABLE EXOGENOUS SOURCE FOR HUMAN EXPOSURE. TOXIC METAL(OID)S SUCH AS CADMIUM AND ARSENIC ARE CLASSIFIED AS PROBABLE CARCINOGENS, AND EMERGING DATA FROM MURINE MODELS SUGGEST THAT EXPOSURE IS ASSOCIATED WITH HEPATIC STEATOSIS, CIRRHOSIS AND LIVER CANCER. PER- AND POLY-FLUOROALKYL SUBSTANCES (PFAS) EXPOSURE IN HUMANS IS ASSOCIATED WITH OBESITY AND NASH. FURTHER, EMERGING EVIDENCE INDICATES THAT THESE ENVIRONMENTAL EXPOSURES CAN INDUCE EPIGENETIC ALTERATIONS THAT MAY PROMOTE ADVERSE EFFECTS ON THE LIVER, BUT WE LACK LONGITUDINAL HUMAN DATA. THESE DATA UNDERSCORE THE NEED FOR LONGITUDINAL HUMAN DATA TO ASSESS WHETHER AND HOW THESE CONTAMINANTS IMPACT HCC RISK. TO ADDRESS THESE KNOWLEDGE GAPS, AND IN RESPONSE TO RFA-CA-20-049, WE PROPOSE THE SOUTHERN LIVER HEALTH STUDY, A LONGITUDINAL COHORT STUDY OF TWO SUB-COHORTS COMPRISING 16,000 MALES AND FEMALES AGED 40 YEARS AND OLDER IN TWO SOUTHEASTERN STATES, NORTH CAROLINA AND GEORGIA. WE WILL TEST THE OVERARCHING HYPOTHESIS THAT CADMIUM ALONE OR IN A MIXTURE WITH OTHER TOXIC METALS AND PFAS INCREASES THE RISK OF PROGRESSION FROM NAFLD TO LIVER FIBROSIS AND HCC. THE COHORT WILL BE RECRUITED FROM COMMUNITY CLINICS INCLUDING FEDERALLY QUALIFIED HEALTH CENTERS AND UNIVERSITY HEALTH SYSTEMS’ PRIMARY CARE CENTERS AND HEPATOLOGY PROGRAMS AT DUKE, UNC CHAPEL HILL AND EMORY. SUB-COHORT I WILL COMPRISE 10,000 OTHERWISE HEALTHY ADULTS WHO WILL BE FOLLOWED FOR 1–5 YEARS, ANTICIPATING THAT ~800 FIBROSIS CASES, INCLUDING CIRRHOSIS, WILL DEVELOP, AND SUB-COHORT II WILL COMPRISE 6,000 ADVANCED FIBROSIS CASES, ANTICIPATING ~750 HCC CASES WILL DEVELOP. WE WILL NEST CASE-CONTROL STUDIES WITHIN THE COHORTS, EVALUATE ASSOCIATIONS BETWEEN ENVIRONMENTAL EXPOSURES AND HCC INCIDENCE, AND IDENTIFY EPIGENETIC MARKS RESPONSIVE TO CONTAMINANTS THAT PREDICT PROGRESSION TO HCC. IMPACT: THIS WILL BE THE FIRST LARGE-SCALE EFFORT TO LONGITUDINALLY DETERMINE THE LINK BETWEEN ENVIRONMENTAL CONTAMINANTS, LIVER DISEASE AND CANCER IN A RESIDENTIALLY AND ETHNICALLY DIVERSE POPULATION. ADDITIONALLY, WE WILL CREATE A DATA AND SPECIMEN REPOSITORY THAT WILL PROVIDE THE RESEARCH COMMUNITY WITH AN INVALUABLE RESOURCE TO STUDY HCC AND OTHER CANCERS.

TRANSFORMATIVE CHANGES ARE NEEDED TO ADDRESS AGRICULTURE&#39;S GRAND CHALLENGE OF INCREASING FOOD PRODUCTION WHILE MAINTAINING ENVIRONMENTAL INTEGRITY. CHANGES MUST MITIGATE: AGRICULTURES HIGH ENERGY DEMAND; IMPENDING WATER SCARCITY AND HERBICIDE-RESISTANT WEEDS; CONSEQUENCES OF CLIMATE CHANGE (MORE FREQUENT FLOODING, DROUGHTS, AND EXTREME HEAT); AND DECLINE IN SOIL HEALTH, CRITICAL FOR IMPROVING SOIL AND WATER QUALITY. THIS PROPOSAL WILL ADDRESS THESE UNPRECEDENTED THREATS BY PROVIDING THE INFRASTRUCTURE NECESSARY TO SUPPORT AND ACCELERATE COVER CROP (CC) USE NATIONWIDE, THEREBY MEETING NIFA PROGRAM GOALS OF 1) INCREASING TOTAL FACTOR PRODUCTIVITY, 2) IMPROVING WATER AND NITROGEN USE EFFICIENCY, AND 3) REDUCING LOSSES DUE TO BIOTIC AND ABIOTIC STRESSES. AN INTEGRATED TRANSDISCIPLINARY APPROACH OF RESEARCH (54%), EXTENSION (30%), AND EDUCATION (16%) COMPONENTS WILL ADDRESS OUR OBJECTIVES TO: 1) TRANSFORM CC DATA CONNECTIVITY VIA NATIONWIDE SOCIAL AND TECHNICAL INFRASTRUCTURE; 2) DEVELOP KEY TECHNOLOGIES TO IMPROVE CC PERFORMANCE, INFORM MANAGEMENT, AND DETERMINE IMPACTS ON AGRONOMIC PRODUCTIVITY, STABILITY, AND ECOSYSTEM SERVICES; 3) DEPLOY KEY TECHNOLOGIES WITH CCS TO ASSESS ABIOTIC AND BIOTIC FACTORS AFFECTING CROP PERFORMANCE; 4) TRANSFORM EDUCATION AND EXTENSION KNOWLEDGE DELIVERY TO CATALYZE CC ADOPTION; AND 5) DETERMINE THE EFFECTIVENESS OF A CC INFORMATION ECOLOGY AS A MODEL FOR INTEGRATING PARTICIPATORY RESEARCH AND PRACTICE. A NATIONWIDE TEAM OF DEDICATED RESEARCH, EXTENSION AND NGO PERSONNEL FROM 28 INSTITUTIONS WILL ESTABLISH ON-STATION AND ON-FARM RESEARCH NETWORKS, NOVEL TEACHING CURRICULUM, AND EXTENSIVE SOCIAL-SCIENCE BASED OUTREACH. OUR OVERALL GOAL IS TO INCREASE CROP PRODUCTIVITY, CONSERVE NATURAL RESOURCES, AND REDUCE OUR AGRO-ECOLOGICAL FOOTPRINT THROUGH INCREASED AND IMPROVED USE OF CCS.

MODEL STATE-SUPPORTED AHEC PROGRAM

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** LEAP RECEIVED USDA-SCRI PLANNING GRANT 2020-51181-32137 AND FOUND THAT LABOR AVAILABILITY IS THE MOST CRITICAL SUSTAINABILITY CHALLENGE FACING NURSERY CROPS PRODUCERS, A LABOR-INTENSIVE INDUSTRY THAT INCLUDES POTTING, PRUNING, STAKING, SCOUTING, WEEDING, TAKING INVENTORY, HARVESTING, AND LOADING ORDERS. NURSERY CROP PRODUCTION RELIES HEAVILY ON FULL-TIME WORKERS AUGMENTED BY SEASONAL EMPLOYEES. SCARCE AVAILABILITY AMONG BOTH IS LIMITING PRODUCERS FROM FACILITATING RURAL PROSPERITY AND ECONOMIC DEVELOPMENT. DESPITE THE ACKNOWLEDGED ADVANTAGES OF AUTOMATING REPETITIVE TASKS, OVERALL ADOPTION OF INNOVATIONS IN NURSERIES IS LOW DUE TO FEW MECHANISMS DESIGNED SPECIFICALLY FOR NURSERY CROPS, AND NO RELIABLE, CONSISTENT DECISION-MAKING AIDS TO DETERMINE ECONOMIC FEASIBILITY. LEAP&#39;S LONG-TERM ECONOMIC BENEFIT IS A SUSTAINABLE US NURSERY INDUSTRY THAT IS MORE RESILIENT TO LABOR SHORTAGES AND THAT DRIVES ECONOMIC GROWTH OF RURAL COMMUNITIES. LEAP&#39;S TRANS-DISCIPLINARY TEAM WILL 1) DEVELOP NEW AUTOMATION AND EVALUATE EXISTING AUTOMATED NURSERY TECHNOLOGIES THAT IMPROVE LABOR EFFICIENCY; 2) EVALUATE SOCIOECONOMIC IMPACTS OF AUTOMATION AND DEVELOP DECISION-MAKING TOOLS TO INFORM ADOPTION STRATEGIES THAT OPTIMIZE THE LIMITED AVAILABLE LABOR; 3) DEVELOP A ROUTE TO ACCELERATE AUTOMATION ADOPTION FOR GROWERS BY MAPPING DIFFUSION OF CURRENT INNOVATIONS THROUGH THEIR INFORMATION-SHARING NETWORKS; 4) ASSESS CONSUMER PREFERENCE AND WILLINGNESS TO PAY FOR IMPACTS TO ECONOMIC, ENVIRONMENTAL, OR WORKER HEALTH BENEFITS BY AUGMENTING TASKS WITH AUTOMATION; AND 5) EDUCATE STAKEHOLDERS WITH LEAP RESOURCES TO INCREASE AWARENESS AND ACCELERATE ADOPTION OF AUTOMATED NURSERY TECHNOLOGIES. LEAP&#39;S OUTCOMES WILL STRENGTHEN PRIVATE LAND STEWARSHIP AND RURAL ECONOMIES BY ACCELERATING AUTOMATION ADOPTION, IMPROVING WORKER EXPERIENCES, ATTRACTING AVAILABLE LABOR, AND CREATING HIGHER SKILLED POSITIONS THEREBY MAXIMIZING SUSTAINBAILITY OF US NURSERIES.

CLINICAL CENTER FOR THE STUDY OF DEV LEARNING UAP

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

NORTH CAROLINA SEA GRANT COLLEGE PROGRAM OMNIBUS 2018-2021

CENTER FOR ENVIRONMENTAL AND HEALTH EFFECTS OF PFAS

A KNOWLEDGE BASE FOR CLINICALLY RELEVANT GENES AND VARIANTS

COMPARATIVE TOXICOGENOMICS DATABASE (CTD)

HIGH ENTROPY CERAMICS FOR HYPERSONICS

JET FUEL FROM CAMELINA SATIVA: A SYSTEMS APPROACH

THE SCIENCE OF ENTROPY STABILIZED ULTRA-HIGH TEMPERATURE MATERIALS

SECURE OPEN SYSTMES INSTITUTE

THE IMPLEMENTATION OF SUSTAINABLE LANDSCAPES SHOULD BE A GOAL IN ALL REGIONS OF THE COUNTRY; HOWEVER, SEVERE DROUGHTS AND LIMITED WATER IN THE SOUTHERN AND WESTERN U.S. ARE DICTATING CHANGESTO THE USE OF SPECIFIC PLANT MATERIALS AND IRRIGATION IN LANDSCAPES. THERE IS A CRITICAL NEED FOR TURFGRASSES THAT PROVIDE FUNCTIONAL SURFACES TOLERANT TO DROUGHT, REDUCED IRRIGATION, AND IRRIGATIONWITH RECLAIMED WATER. FAILURE TO ADDRESS THESE CHALLENGES WILL RESULT IN LOSS OF TURFGRASS AREAS, ALONG WITH THEIR ECONOMIC, ENVIRONMENTAL AND SOCIAL BENEFITS. THIS TRANSDISCIPLINARY GROUP FROM SIXUNIVERSITIES WAS FORMED IN 2010 TO ADDRESS THESE PROBLEMS BY DEVELOPING TURFGRASSES WITH REDUCED IRRIGATION REQUIREMENTS. TO DATE, OUR GROUP HAS RELEASED SIX IMPROVED CULTIVARS FOR THREE OF THE MOSTECONOMICALLY IMPORTANT TURFGRASS SPECIES GROWN IN THESE REGIONS. SIGNIFICANT OPPORTUNITIES REMAIN TO ADVANCE DROUGHT AND SALINITY TOLERANT TURFGRASSES WITH INNOVATIONS IN GENOMICS THAT LEVERAGE THE SUCCESSFUL ECONOMIC IMPACTS OF OUR PREVIOUS WORK WITH EVOLVING INDUSTRY NEEDS AND SOCIETAL PREFERENCES. THE LEVELS OF IMPROVEMENT OF OUR RELEASED CULTIVARS ARE PROMISING AND SUBSTANTIATE THE NEED FOR CONTINUED QUANTIFICATION OF THEIR REDUCED WATER USE. IMPLEMENTING EDUCATION AND OUTREACH EFFORTS TO INCREASE THEIR ADOPTION WILL MAXIMIZE THE ECONOMIC AND ENVIRONMENTAL IMPACT OF THESE GRASSES. ADVANCING OUR SUCCESSFUL RESEARCH RELATIONSHIP WILL INCREASE THE EFFICIENCY OF CULTIVAR DEVELOPMENT THROUGH USE OF NEW SCREENING TOOLS AND TECHNOLOGIES, AND DISSEMINATION OF INFORMATION TO STAKEHOLDERS AND END-USERS. ULTIMATELY, THESE EFFORTS WILL FACILITATE OUR LONG-TERM GOAL OF REDUCING WATER CONSUMPTION IN LANDSCAPES THROUGH THE CONTINUED DEVELOPMENT AND INCREASED UTILIZATION OF DROUGHT TOLERANT TURFGRASSES.

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE NATIONAL JUNTOS CONSORTIUM (NJC) AND STEM AP IS A TRANSFORMATIONAL, INTERDISCIPLINARY, COLLABORATIVE PROJECT THAT WILL PREPARE LATINX YOUTH TO BECOME THE NEXT GENERATION OF LEADERS AND WORKFORCE IN STEM AND AGRISCIENCE. LED BY NCSU, STEM AP WILL IMPROVE STEM PARTICIPATION, PERSISTENCE, AND CAREER READINESS AMONG LATINX YOUTH IN NORTH CAROLINA AND WASHINGTON. THE PROJECTDRAWS FROM CULTURALLY RESPONSIVE PEDAGOGY, BEHAVIORAL SCIENCE THEORY, AND EVIDENCE-BASED PRACTICE, AND WILL ESTABLISH A REPLICABLE, SCALABLE PROGRAM THAT IMPROVES LATINX YOUTH REPRESENTATION IN POST-SECONDARY STEM EDUCATION PROGRAMS AND ADVANCES DEIA WORK WITHIN THE LGU EXTENSION SYSTEM. THE PROJECT OBJECTIVES INCLUDE:INCREASE OPPORTUNITIES FOR LATINX YOUTH TO ENGAGE IN STEM EDUCATION AND WORKFORCE ACTIVITIES;ENHANCE THE SKILLS AND CAPACITIES OF LATINX YOUTH TO ENGAGE WITH STEM APP LEARNING AND CAREER OPPORTUNITIES; ANDINCREASE THE MOTIVATION OF STEM APP YOUTH TO ENGAGE IN STEM-RELATED LEARNING AND CAREER OPPORTUNITIES.DEVELOP THE NATIONAL JUNTOS CONSORTIUM TO SUPPORT THE SCALABILITY AND SUSTAINABILITY OF JUNTOS AND JUNTOS STEM AP.THROUGH THIS INNOVATIVE APPROACH, COMBINING 4-H THRIVING MODEL, POSITIVE YOUTH DEVELOPMENT, AND THE BEHAVIOR CHANGE PROCESS AS DEFINED WITHIN THE COM-B FRAMEWORK, THE PROJECT WILL INCREASE LATINX YOUTH STEM IDENTITY (I.E. SEEING THEMSELVES AS SUCCESSFUL IN A STEM CAREER PATHWAY) AND THE LIKELIHOOD TO PURSUE AND BE SUCCESSFUL IN A STEM (AGRICULTURAL SCIENCES) CAREER. THE PROJECT WILL ALSO LAUNCH THE NATIONAL JUNTOS CONSORTIUM, A FIRST-OF-ITS-KIND COLLABORATIVE EXTENSION INITIATIVE WITH REPRESENTATION IN ALL NATIONAL REGIONS FOCUSED ON DIVERSITY, EQUITY, INCLUSION, AND ACCESS.?ONE OF THE FASTEST-GROWING AND YOUNGEST GROUPS IN THE US, HISPANICS COMPRISED NEARLY 19% OF THE AMERICAN POPULATION IN 2020 (JONES ET AL., 2021). YET, HISPANICS MAKE UP 17% OF THE WORKFORCE BUT ONLY 8% OF WORKERS IN STEM FIELDS (FRY ET AL., 2021). NATIONALLY, HISPANIC STUDENTS WITH A STEM BACHELOR&#39;S DEGREE ARE ALSO UNDERREPRESENTED AT JUST 12% (BURKE ET AL., 2021). ADDRESSING THIS EQUITY GAP WILL REQUIRE A GROWING NUMBER OF HISPANIC YOUTH TO PURSUE STEM EDUCATION AND CAREER OPPORTUNITIES. AS NOTED BY CRISP AND NORA (2012), EFFORTS TO INCREASE THE REPRESENTATION OF HISPANICS IN STEM-RELATED OCCUPATIONS...IS NOT ONLY ETHICALLY AND MORALLY CORRECT, AS THESE GROUPS DESERVE EQUAL ACCESS TO STEM FIELDS, BUT ALLOWS MINORITY GROUPS TO SERVE AS ROLE MODELS AND MENTORS FOR YOUNGER MEMBERS OF THEIR OWN ETHNIC/RACIAL GROUP.AEAP FILLS A CRITICAL NEED FOR INCREASING CULTURALLY RESPONSIVE STEM CAREER ENGAGEMENT, ACCESS, AND A SENSE OF BELONGING AMONG LATINX PEOPLE.

CENTER: NSF ENGINEERING RESEARCH CENTER FOR TRANSFORMATION OF AMERICAN RUBBER THROUGH DOMESTIC INNOVATION FOR SUPPLY SECURITY (TARDISS) -THE GENERATION-4 NSF ENGINEERING RESEARCH CENTER TITLED ?TRANSFORMATION OF AMERICAN RUBBER THROUGH DOMESTIC INNOVATION FOR SUPPLY SECURITY: TARDISS? WILL LEAD FUNDAMENTAL RESEARCH TOWARDS US NATURAL RUBBER BIOMANUFACTURING. CURRENTLY THE SINGLE COMMERCIAL SOURCE OF NATURAL RUBBER IS THE TROPICAL RUBBER TREE (HEVEA BRASILIENSIS), WITH PRODUCTION AREAS ALL OUTSIDE OF THE UNITED STATES. TARDISS WILL USE A SYSTEMS ENGINEERING APPROACH TO INTEGRATE ENGINEERING WITH BIOLOGY, BIOTECHNOLOGY, AGRICULTURE, AND OTHER DISCIPLINES OPTIMIZING ALTERNATIVE PLANTS TO PRODUCE ENTIRELY NEW NATURAL RUBBER MATERIALS AT SCALE. THE TARDISS TEAM WILL COLLABORATE WITH COMMUNITIES, FARMERS, PROCESSORS AND RUBBER MANUFACTURERS TO ENABLE BIOMANUFACTURING-BASED NATURAL RUBBER PRODUCTION OPTIMIZED TO LARGE PARTS OF THE US, WITH A FOCUS ON MARGINAL AGRICULTURAL LANDS. TARDISS WILL ENABLE A CIRCULAR BIOMANUFACTURING ECONOMY THAT RESPECTS NATURAL SYSTEMS, INCLUDING POLLINATOR SERVICES BY THE NEW DOMESTIC CROPS, WATER RECYCLING AND RE-USE, ADDITIONAL CO2 CAPTURE, AND AN ESTIMATED 2 MILLION JOBS TIED TO US SOIL. ENGINEERING WORKFORCE DEVELOPMENT WILL PROVIDE TRAINING IN THIS NEW U.S. AREA, ALSO INCLUDE THOSE WITH UNTAPPED POTENTIAL THAT ARE CURRENTLY UNDERUTILIZED IN THE WORKFORCE. THE OUTCOMES WILL BE A SUSTAINABLE DOMESTIC RUBBER INDUSTRY AND A NEW, YOUNG WORKFORCE CONVERGING ENGINEERING AND AGRICULTURE TRAINED THROUGH A NEW AMERICAN RUBBER ACADEMY. THE ?U.S. SUNLIGHT TO MATERIALS? VISION MOTIVATING THE SYSTEMS ENGINEERING APPROACH OF TARDISS IS ENCAPSULATED BY TWO HYPOTHESES: #1: THE U.S. CAN REPLACE IMPORTED NATURAL RUBBER (NR) WITH RUBBER FROM DOMESTIC CROPS, UTILIZING MARGINAL AGRICULTURAL LANDS, HYDROPONIC SYSTEMS, AND NEW EXTRACTION METHODS; AND #2: THE U.S. CAN REPLACE IMPORTED GOODS WITH PRODUCTS MADE WITH HOME-GROWN NATURAL RUBBER. TARDISS WILL INTEGRATE ENGINEERING WITH BIOLOGY AND OTHER SCIENCE DISCIPLINES VIA THE FOLLOWING THREE RESEARCH THRUSTS: 1: BIOENGINEERING WILL CONVERGE ENGINEERING, BIOCHEMISTRY, ENZYME CHEMISTRY, AND MOLECULAR BIOLOGY TO FUNDAMENTALLY UNDERSTAND HOW PLANTS NATURALLY PRODUCE RUBBER. NATURAL VARIETY WILL BE COMBINED WITH GENETIC APPROACHES TO TAILOR HYDROPONIC DANDELION TO PRODUCE NEW NR VARIANTS AND TRANSFER THE KNOWLEDGE TO THE GUAYULE AND MOUNTAIN GUM PLANT SPECIES. 2: CROP ENGINEERING WILL CONVERGE PLANT AND AGRICULTURAL ENGINEERING TO DEVELOP AND DISSEMINATE NEW ?SMART? CROP PRODUCTION PRACTICES FOR ALL THREE CROPS. 3: LATEX/RUBBER ENGINEERING WILL CONVERGE ENGINEERING, MATERIALS/POLYMER SCIENCE AND ENGINEERING, CHEMISTRY, AND PHYSICS TO INVENT EXTRACTION METHODS TO PRODUCE CONSISTENT HIGH-PERFORMANCE LATEX AND RUBBER AND NEW PROCESSING METHODS FOR PRODUCTS. FURTHERMORE, TARDISS WILL INVENT ENABLING TECHNOLOGIES IN FIELD AND HYDROPONIC SYSTEMS, INDUSTRIAL SCALE LATEX AND RUBBER EXTRACTION METHODS, AND NOVEL PROCESSES-FOR-PRODUCTS AND BRING THESE TO COMMUNITIES. A SEAMLESS INTEGRATION OF SCALABLE BIOLOGY, ENGINEERING, AND SCIENCE, WHILE CO-DEVELOPING ECONOMICALLY SCALABLE PATHWAYS WITH DOMESTIC STAKEHOLDERS, WILL BE CRITICAL FOR SUCCESS IN CONVERGENT RESEARCH. THE OUTCOMES WILL BE A SUSTAINABLE DOMESTIC RUBBER INDUSTRY AND A NEW, YOUNG WORKFORCE CONVERGING AGRICULTURE AND ENGINEERING TRAINED THROUGH A NEW AMERICAN RUBBER ACADEMY IN COLLABORATION WITH THE RUBBER DIVISION OF THE AMERICAN CHEMICAL SOCIETY. THE TARDISS INNOVATION ECOSYSTEM WILL BRING TOGETHER AMERICAN BUSINESS LEADERS AND ENTREPRENEURS, RESEARCHERS, STUDENTS, NATIONAL LABS, AND COMMUNITIES, AND FEATURES NOVEL PROGRAMS SUCH AS THE PIRANHA PIT TO ENCOURAGE INNOVATION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

RURAL HEALTH RESEARCH GRANT PROGRAM COOPERATIVE AGREEMENT

TARGETED ANTICOAGULANT THERAPY FOR SICKLE CELL DISEASE

METHOTREXATE RESPONSE IN TREATMENT OF UC - MERIT-UC

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** FIR (ABIES SPP.) ACCOUNT FOR 66%+ OF THE ANNUAL $2.5 BILLION US CHRISTMAS TREE INDUSTRY. THE ENVIRONMENTAL IMPACT OF REAL VERSUS ARTIFICIAL TREES SHOW A LOCALLY GROWN CHRISTMAS TREE IS THE MORE SUSTAINABLE CHOICE AS IT CAN SEQUESTER CARBON FROM THE ATMOSPHERE. OPTIMIZATION OF CHRISTMAS TREE FARMS AS GREENHOUSE GAS SINKS HAS POTENTIAL TO BECOME A NET-POSITIVE CLIMATE ACTIVITY THROUGH INCENTIVIZATION OF CARBON OFFSET PROGRAMS. PLANTING GENETICALLY IMPROVED FIR CHRISTMAS TREES HOLDS SIGNIFICANT PROMISE FOR THE US CHRISTMAS TREE INDUSTRY TO COMBAT CLIMATE CHANGE AND PROVIDE ADDED VALUE TO FARMERS. ACROSS THE US, CHRISTMAS TREE PLANTING STOCK IS DERIVED FROM GERMPLASM OF UNKNOWN GENETIC ORIGIN. THEREFORE, THE GENETIC VALUE OF EXTANT PLANTED MATERIALS CANNOT BE DETERMINED. TO ADDRESS THIS CONCERN, NORTH CAROLINA HAS ESTABLISHED A STATE FUNDED BREEDING PROGRAM DEDICATED TO GENETIC IMPROVEMENT OF FRASER FIR. A PRIMARY GOAL OF THIS PROJECT IS TO EXTEND GENETIC IMPROVEMENT CAPABILITIES, ACCELERATE THE DOMESTICATION PROCESS, AND DELIVER INCREASED VALUE TO THE US CHRISTMAS TREE INDUSTRY THROUGH A TRANSDISCIPLINARY, SYSTEMS-BASED APPROACH. IN ADDITION, WE PLAN TO IDENTIFY ECONOMIC BENEFITS OF GENETICALLY IMPROVED FIR CHRISTMAS TREES WITH ENHANCED CLIMATE RESILIENCE, PEST AND PATHOGEN RESISTANCE, CONSUMER PREFERENCES, AND REDUCTION IN LABOR COSTS. THE GOAL IS TO IMPLEMENT MODERN GENETIC IMPROVEMENT METHODS FOR THE U.S. CHRISTMAS TREE INDUSTRY. WE PLAN TO DEVELOP LOW-COST, HIGH-THROUGHPUT GENOTYPING ASSAYS BASED ON GENOME ASSEMBLIES OF COMMERCIALLY IMPORTANT FIR SPECIES AND SCALE UP SOMATIC EMBRYOGENESIS TECHNIQUES FOR RAPID PROPAGATION OF ELITE FIR GERMPLASM TO THE U.S. CHRISTMAS TREE INDUSTRY.

SERVING OUR COAST FROM AND BEYOND

COMPARATIVE MEDICINE AND TRANSLATIONAL RESEARCH TRAINING PROGRAM

PURPOSE: THE PURPOSE OF THIS APPLICATION IS TO SECURE CONTINUED FUNDING FOR THE NORTH CAROLINA MANUFACTURING EXTENSION PARTNERSHIP (NCMEP) TO SUPPORT AND ENHANCE THE COMPETITIVENESS OF SMALL AND MEDIUM-SIZED MANUFACTURERS (SMMS) ACROSS THE STATE. FOR NEARLY THREE DECADES, NCMEP HAS BEEN INSTRUMENTAL IN DRIVING PRODUCTIVITY IMPROVEMENTS, WORKFORCE DEVELOPMENT, AND TECHNOLOGICAL ADVANCEMENTS FOR MANUFACTURERS, ENSURING THAT NORTH CAROLINA REMAINS A LEADER IN THE MANUFACTURING SECTOR. ADMINISTERED BY INDUSTRY EXPANSION SOLUTIONS (IES) AT NORTH CAROLINA STATE UNIVERSITY, NCMEP SERVES AS A CRITICAL RESOURCE FOR BUSINESSES SEEKING TO OPTIMIZE OPERATIONS, EXPAND MARKET OPPORTUNITIES, AND ADOPT INNOVATIVE TECHNOLOGIES.ACTIVITIES TO BE PERFORMED: THE ACTIVITIES TO BE PERFORMED UNDER THIS INITIATIVE WILL FOCUS ON PROVIDING CUSTOMIZED SERVICES AND EXPERTISE TO MANUFACTURERS THROUGHOUT NORTH CAROLINA. KEY AREAS OF SUPPORT INCLUDE PROCESS IMPROVEMENT INITIATIVES SUCH AS LEAN MANUFACTURING, SIX SIGMA, AND EFFICIENCY ENHANCEMENT PROGRAMS. WORKFORCE DEVELOPMENT EFFORTS WILL BE PRIORITIZED TO UPSKILL EMPLOYEES AND PREPARE THEM FOR EVOLVING INDUSTRY DEMANDS. ADDITIONALLY, NCMEP WILL ASSIST MANUFACTURERS IN BUSINESS GROWTH STRATEGIES, MARKET EXPANSION, AND SUPPLY CHAIN OPTIMIZATION TO ENHANCE RESILIENCE AND MITIGATE RISKS. EMPHASIS WILL ALSO BE PLACED ON TECHNOLOGY TRANSFER AND IMPLEMENTATION, HELPING MANUFACTURERS ADOPT CUTTING-EDGE DIGITAL MANUFACTURING SOLUTIONS, AUTOMATION, AND SMART FACTORY TECHNOLOGIES. FURTHERMORE, NCMEP WILL FACILITATE CONNECTIONS BETWEEN MANUFACTURERS AND VITAL RESOURCES, INCLUDING FEDERAL AND STATE AGENCIES, INDUSTRY ASSOCIATIONS, RESEARCH INSTITUTIONS, AND FUNDING OPPORTUNITIES.EXPECTED OUTCOMES: THE EXPECTED OUTCOMES OF THESE EFFORTS INCLUDE INCREASED PRODUCTIVITY AND OPERATIONAL EFFICIENCY AMONG NORTH CAROLINA MANUFACTURERS, RESULTING IN ENHANCED COMPETITIVENESS AND LONG-TERM BUSINESS GROWTH. THE PROGRAM AIMS TO CULTIVATE A HIGHLY SKILLED WORKFORCE, ENSURING THAT EMPLOYEES ARE WELL-EQUIPPED TO MEET THE CHALLENGES OF MODERN MANUFACTURING. ADDITIONALLY, STRENGTHENING SUPPLY CHAINS AND PROMOTING THE ADOPTION OF ADVANCED TECHNOLOGIES WILL DRIVE INNOVATION ACROSS THE SECTOR. ULTIMATELY, THESE EFFORTS WILL CONTRIBUTE TO A POSITIVE ECONOMIC IMPACT, LEADING TO JOB RETENTION, BUSINESS EXPANSION, AND REVENUE GROWTH FOR NORTH CAROLINA'S MANUFACTURING ECOSYSTEM.INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES OF NCMEP'S INITIATIVES INCLUDE SMALL AND MEDIUM-SIZED MANUFACTURERS ACROSS NORTH CAROLINA, WHO WILL GAIN ACCESS TO CRITICAL RESOURCES, TRAINING, AND CONSULTING SERVICES. MANUFACTURING EMPLOYEES WILL BENEFIT FROM SPECIALIZED WORKFORCE DEVELOPMENT PROGRAMS THAT ENHANCE THEIR SKILLS AND CAREER PROSPECTS. ADDITIONALLY, STATE AND REGIONAL ECONOMIC DEVELOPMENT ORGANIZATIONS WILL LEVERAGE NCMEP'S EXPERTISE TO SUPPORT INDUSTRIAL GROWTH AND ATTRACT INVESTMENTS TO THE REGION. GOVERNMENT AGENCIES AND PRIVATE-SECTOR PARTNERS COLLABORATING ON WORKFORCE DEVELOPMENT AND TECHNOLOGY-DRIVEN MANUFACTURING ADVANCEMENTS WILL ALSO BENEFIT FROM NCMEP'S LEADERSHIP AND STRATEGIC INITIATIVES.SUBRECIPIENT ACTIVITIES: SUBRECIPIENT ACTIVITIES UNDER THIS INITIATIVE WILL BE CARRIED OUT IN PARTNERSHIP WITH VARIOUS ORGANIZATIONS TO MAXIMIZE SERVICE DELIVERY AND REACH. EDUCATIONAL INSTITUTIONS WILL PLAY A KEY ROLE IN PROVIDING WORKFORCE TRAINING PROGRAMS AND RESEARCH COLLABORATIONS. INDUSTRY ASSOCIATIONS WILL SUPPORT BUSINESS DEVELOPMENT EFFORTS AND CREATE NETWORKING OPPORTUNITIES FOR MANUFACTURERS. ECONOMIC DEVELOPMENT ORGANIZATIONS WILL ASSIST IN SECURING FUNDING AND STRATEGIC PLANNING TO DRIVE REGIONAL GROWTH. ADDITIONALLY, TECHNOLOGY PROVIDERS WILL COLLABORATE WITH NCMEP TO FACILITATE THE IMPLEMENTATION OF DIGITAL TRANSFORMATION INITIATIVES, ENSURING THAT MANUFACTURERS STAY COMPETITIVE IN AN INCREASINGLY TECHNOLOGY-DRIVEN MARKET.

STUDENTS DISCOVER: IMPROVING MIDDLE SCHOOL STEM OUTCOMES THROUGH SCALING CITIZEN SCIENCE PROJECTS

COLLABORATIVE PROPOSAL: SATC: FRONTIERS: ENABLING A SECURE AND TRUSTWORTHY SOFTWARE SUPPLY CHAIN -THE MODERN WORLD RELIES ON SOFTWARE IN ALMOST EVERY HUMAN ENDEAVOR, AND A TYPICAL SOFTWARE PRODUCT INCLUDES 80% OPEN SOURCE COMPONENTS. ATTACKERS FIND AND EXPLOIT ACCIDENTALLY-INJECTED SECURITY VULNERABILITIES AND, INCREASINGLY, AGGRESSIVELY IMPLANT VULNERABILITIES OR MALICIOUS CODE DIRECTLY INTO THE SOFTWARE SUPPLY CHAIN -- THE OPEN SOURCE SOFTWARE AND ITS BUILD AND DEPLOYMENT PIPELINES. THIS FRONTIERS PROJECT ESTABLISHES THE SECURE SOFTWARE SUPPLY CHAIN CENTER (S3C2), A LARGE-SCALE, MULTI-INSTITUTION EFFORT DESIGNED TO AID THE SOFTWARE INDUSTRY RE-ESTABLISH TRUST IN THE SOFTWARE SUPPLY CHAIN THROUGH THE DEVELOPMENT OF SCIENTIFIC PRINCIPLES, SYNERGISTIC TOOLS, METRICS, AND MODELS IN THE CONTEXT OF HUMAN BEHAVIOR AMONG SOFTWARE SUPPLY CHAIN STAKEHOLDERS. THE PROJECT?S NOVELTIES INCLUDE THE CONTRIBUTIONS TO A DIVERSE WORKFORCE THAT IS TRAINED IN SECURE SOFTWARE SUPPLY CHAIN METHODS THROUGH RESEARCH AND OUTREACH INITIATIVES, INCLUDING SUMMER RESEARCH EXPERIENCES FOR UNDERGRADUATES (REU), SUMMER CAMPS, AND THE DEVELOPMENT OF COURSE MODULES FOR UNDERGRADUATES, GRADUATE STUDENTS, AND PRACTITIONERS. THE PROJECT?S BROADER SIGNIFICANCE AND IMPORTANCE ARE THE WAYS IN WHICH S3C2 WILL FACILITATE RAPID INNOVATION WITH INCREASED CONFIDENCE IN SOFTWARE SUPPLY CHAIN SECURITY. S3C2 FOCUSES ON INTERCONNECTED RESEARCH THRUSTS FOR TWO SUPPLY CHAIN ATTACK VECTORS: (1) UPSTREAM DEPENDENCIES AND (2) THE BUILD PROCESS IN THE CONTEXT OF A CONTINUOUS INTEGRATION/CONTINUOUS DEPLOYMENT (CI/CD) PIPELINE. THRUST ONE FOCUSES ON DEVELOPING TOOLS AND TECHNIQUES TO AID PRACTITIONERS WITH THE RISK OF UPSTREAM DEPENDENCIES. IT ENHANCES THE UTILITY OF THE SOFTWARE BILL OF MATERIALS (SBOM) BY IDENTIFYING EXPLOITABILITY OF VULNERABILITIES AND CHANGES TO ATTACK SURFACES AND ISOLATES RISKY CODE AS A STOP-GAP BEFORE PATCHING IS POSSIBLE. THRUST TWO FOCUSES ON DEVELOPING TOOLS AND TECHNIQUES TO AID PRACTITIONERS WITH THE RISK OF BUILD PROCESSES. IT ENABLES STRONG GUARANTEES FOR BUILD INTEGRITY THROUGH ANALYSIS OF CI/CD CONFIGURATION AND TECHNIQUES THAT HELP DEVELOPERS ACHIEVE REPRODUCIBLE BUILDS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

SOUND AND ELECTROMAGNETIC INTERACTING WAVES

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

COMPARATIVE TOXICOGENOMICS DATABASE (CTD) - ABSTRACT MOST HUMAN DISEASES INVOLVE INTERACTIONS BETWEEN GENETIC AND ENVIRONMENTAL FACTORS. ALTHOUGH THE ENVIRONMENT IS IMPLICATED IN MOST CHRONIC DISEASES, THE ETIOLOGY AND MECHANISMS OF ACTION UNDERLYING THESE DISEASES REMAIN UNCLEAR. IT IS ESTIMATED THAT MORE THAN 80,000 CHEMICALS ARE CURRENTLY USED IN COMMERCE, CHALLENGING ELUCIDATION ABOUT CHEMICAL MECHANISMS-OF-ACTION AND PRIORITIZATION OF ENVIRONMENTAL HEALTH RESEARCH. INTEGRATION OF DIVERSE DATA IS REQUIRED TO UNDERSTAND ENVIRONMENT- DISEASE ASSOCIATIONS, MECHANISMS OF CHEMICAL ACTION, TOXICITY PREDICTION AND DEVELOPMENT OF EFFECTIVE THERAPEUTIC INTERVENTIONS. IN 2004, THE COMPARATIVE TOXICOGENOMICS DATABASE (CTD; HTTP://CTDBASE.ORG) WAS LAUNCHED PUBLICLY TO ADDRESS AN UNMET NEED FOR A PUBLIC DATA RESOURCE DEDICATED EXCLUSIVELY TO ADVANCING UNDERSTANDING ABOUT ENVIRONMENT-DISEASE CONNECTIONS. TODAY, THROUGH DIVERSIFIED FUNDING APPROACHES AND IN RESPONSE TO THE EVOLVING NEEDS OF THE ENVIRONMENTAL HEALTH RESEARCH COMMUNITY, CTD PROVIDES A COMBINATION OF RICHLY ANNOTATED DATA DESCRIBING CHEMICAL- GENE-PHENOTYPE-DISEASE NETWORKS, EXPOSURE INFORMATION, AND NOVEL ANALYSIS TOOLS THAT ENABLE USER- DRIVEN DISCOVERIES ABOUT ENVIRONMENTAL INFLUENCES ON HUMAN HEALTH. CURRENTLY, CTD PROVIDES >2.5 MILLION MANUALLY CURATED RELATIONSHIPS FOR 16,400 CHEMICALS, 51,300 GENES/PROTEINS, 5,500 PHENOTYPES, AND 7,200 DISEASES, CONTEXTUALIZED WITH OVER 870 ANATOMICAL TERMS FROM APPROXIMATELY 600 SPECIES. CTD CURATED DATA HAS BEEN INTEGRATED INTO >145 OTHER BIOMEDICAL RESOURCES FURTHER EXTENDING THE REACH OF ITS IMPACT. CTD HAS BECOME A VALUED RESOURCE ON WHICH THE ENVIRONMENTAL HEALTH RESEARCH COMMUNITY RELIES. WE ARE REQUESTING FUNDING TO: 1) CONTINUE ADVANCING UNDERSTANDING ABOUT THE COMPLEX CONNECTIONS BETWEEN ENVIRONMENTAL EXPOSURES AND HUMAN HEALTH THROUGH ONGOING MANUAL CURATION OF CHEMICALS, GENES, PHENOTYPES, DISEASES AND EXPOSURE DATA FROM THE SCIENTIFIC LITERATURE; EVALUATION AND INTEGRATION OF SELECT EXTERNAL DATA SETS; AND BASELINE TECHNICAL SUPPORT; 2) ENHANCE CURATION EFFICIENCY THROUGH FURTHER DEVELOPMENT OF OUR TEXT-MINING AND ONLINE CURATION TOOLS; AND 3) SELECTIVELY RESTRUCTURE EXISTING CODE, SOFTWARE, AND DATABASE DESIGN (REFACTORING) TO IMPROVE THE STRUCTURE AND PERFORMANCE OF CTD. THIS PROPOSED PROJECT WILL PROTECT AND EXTEND NIH INVESTMENTS IN CTD AND ENSURE THE ONGOING PROVISION OF THIS KEY RESOURCE FOR THE ENVIRONMENTAL HEALTH RESEARCH COMMUNITY.

CHILDHOOD OBESITY PREVENTION AND TREATMENT RESEARCH COORDINATING UNIT

SCIENCE SERVING OUR COAST AND BEYOND 2010-2014 OMNIBUS PROPOSAL

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

EPIGENOME DYNAMICS DURING DNA REPLICATION

FL3X: AN ADAPTIVE INTERVENTION TO IMPROVE OUTCOMES FOR YOUTH WITH TYPE 1 DIABETES

SUSTAINABLE STRATEGIES TO MANAGE SPOTTED WIND DROSOPHILA IN UNITED STATES FOOD CROPS.

FAS PREVENTION: A TRIAL OF THE IOM MODEL

OUR PORTFOLIOS OF SOLUTIONDRIVEN, CUTTINGEDGE RESEARCH IS CREATING NEW KNOWLEDGE AND TECHNOLOGY WHICH IS THEN EXTENDED TO ALL NORTH CAROLINIANS THROUGH NC COOPERATIVE EXTENSION. WE ARE TRANSFORMING SCIENCE INTO EVERYDAY SOLUTIONS THAT IMPROVE LIVES AND ALLOW NORTH CAROLINIANS TO LEAD PROSPEROUS, HEALTHY LIVES. A STATEWIDE NETWORK OF EXTENSION AGENTS SERVES AS THE CONDUIT THROUGH WHICH THE NEEDS OF THE COMMUNITY ARE COMMUNICATED TO UNIVERSITY RESEARCHERS WHO THEN CONDUCT RESEARCH AND FORMULATE SOLUTIONS. EXTENSION AGENTS THEN DELIVER ESSENTIAL INFORMATION INTO THE HANDS OF GROWERS, INDUSTRY, AND MEMBERS OF THE COMMUNITY. RESEARCH AND EXTENSION EFFORTS AT NC STATE FOCUS ON ADDRESSING FOUR IDENTIFIED STATEWIDE CRITICAL ISSUES: IMPROVING PLANT AND ANIMAL AGRICULTURAL SYSTEMS; PROTECTING ENVIRONMENTAL RESOURCES, ENRICHING YOUTH, FAMILY AND COMMUNITY WELLBEING; AND ENHANCING FOOD SAFETY, NUTRITION AND HEALTH. THROUGH INTEGRATED RESEARCH AND EXTENSION PROGRAMS, NC STATE IS SOLVING CHALLENGES RELATED TO THE PRODUCTIVITY AND PROFITABILITY OF BOTH LARGE AND SMALLSCALE FARMS. RESEARCHERS AND EXTENSION EDUCATORS ARE ALSO DEVELOPING AND DISSEMINATING KNOWLEDGE AND TECHNOLOGY TO IMPROVE LANDSCAPING AND GARDENING. RESEARCH AND EXTENSION PROGRAMS IN ANIMAL SYSTEMS ARE FOCUSED ON DEVELOPING AND DISSEMINATING KNOWLEDGE AND METHODS FOR ANIMAL BREEDING, REPRODUCTION, NUTRITION, GENETICS AND GENOMICS, PHYSIOLOGY, ENVIRONMENTAL STRESS, PRODUCT QUALITY, AND HEALTH AND WELLBEING. THESE INTEGRATED RESEARCH AND EXTENSION EFFORTS ALSO AIM TO TACKLE THE CRITICAL ISSUES IMPACTING THE QUALITY OF OUR SOIL, WATER AND AIR BY PROVIDING SCIENTIFIC SOLUTIONS FOR ANIMAL WASTE MANAGEMENT, WASTEWATER TREATMENT, NUTRIENT MANAGEMENT, SEPTIC SYSTEMS, WETLAND MANAGEMENT, SOIL PROPERTIES, AND FISHERY AND POND MANAGEMENT. NC STATE EXTENSION CONTINUES TO PROVIDE OPPORTUNITIES TO ENRICH YOUTH, FAMILY AND COMMUNITY WELLBEING THROUGH THE 4H YOUTH DEVELOPMENT PROGRAM. 4H PROGRAMS INCREASE OPPORTUNITIES FOR YOUTH TO DEVELOP LIFE SKILLS, GROW CONFIDENCE, INDEPENDENCE, RESILIENCE, AND STEM SKILLS THROUGH FUN HANDSON LEARNING IN SAFE, HEALTHY, AND ENRICHING ENVIRONMENTS. EXTENSION PROGRAMS ALSO ADDRESS CRITICAL CHALLENGES AFFECTING CONSUMER AND FAMILY WELLBEING. IN ADDITION TO YOUTH DEVELOPMENT, OTHER FOCUS AREAS INCLUDE PARENTING, CHILDCARE, FAMILY RELATIONSHIPS, FINANCIAL MANAGEMENT, AGING, HEALTHY HOMES, AND DISASTER READINESS, RESPONSE, AND RECOVERY. AT THE COMMUNITY LEVEL, EXTENSION WORKS WITH INDIVIDUALS, COMMUNITY GROUPS AND LOCAL GOVERNMENTS ON LEADERSHIP SKILLS, WORKFORCE DEVELOPMENT, ENTREPRENEURSHIP, CIVIC ENGAGEMENT, VOLUNTEERISM, COMMUNITY PLANNING, AND DISASTER PREPAREDNESS. NC STATES RESEARCH AND EXTENSION EFFORTS TO ENHANCE FOOD SAFETY, NUTRITION AND HEALTH AND TO KEEP AMERICANS HEALTHY AND FREE FROM FOODBORNE ILLNESS NECESSITATE A FOCUS ON PREVENTING FOOD SAFETY PROBLEMS RATHER THAN TAKING A REACTIONARY APPROACH. NC STATES INTEGRATED RESEARCH AND EXTENSION EFFORTS FOCUS ON PROTECTING THE SAFETY OF FOODS ALONG THE ENTIRE SUPPLY CHAIN, FROM PRODUCTION TO CONSUMPTION. TO MEET THE GROWING NEED FOR HEALTHY FOOD, RESEARCHERS ARE DEVELOPING AND PRODUCING NEW FOOD PRODUCTS THAT PROMOTE HEALTH AND PREVENT DISEASE. AT THE SAME TIME, EXTENSION PROVIDES NUTRITION EDUCATION PROGRAMMING TO ENSURE THAT INDIVIDUALS, FAMILIES, AND COMMUNITIES HAVE THE KNOWLEDGE THEY NEED TO MAKE INFORMED CHOICES ABOUT FOOD AND HEALTHY LIFESTYLES. IMPROVING PLANT AND ANIMAL AGRICULTURAL SYSTEMS: WITHIN THIS AREA, WE WILL WORK TO ADDRESS CROSSCUTTING AND EMERGING ISSUES OF ANIMAL AND PLANT HEALTH AND PRODUCTION. IN ANIMAL SYSTEM, RESEARCHERS WILL STUDY THE EFFICIENCY OF DIFFERENT FEEDING SOURCES TO IMPROVE ANIMAL PRODUCTIVITY AND GUT HEALTH. IN PLANT SYSTEMS, THE FOCUS WILL BE IN SUSTAINABLE AGRICULTURE, ALTERNATIVE AND HIGH VALUE CROP PRODUCTION, SEASON EXTENSION, CLIMATE CHANGE ADAPTATION, VALUE ADDED AGRICULTURE, DIGITAL AGRICULTURE, SOIL HEALTH, PEST CONTROL, AND AGRO ECONOMICS. EXTENSIONWILL CONTINUE TO EXPAND ITS WORK WITH LIVESTOCK PRODUCERS, PLACING SPECIAL EMPHASIS ON LIMITED RESOURCES, SMALL SCALE MINORITY FARMERS. THE FARM PAVILION WILL FOCUS ON SUSTAINABLE AGRICULTURE AND LOCAL AND COMMUNITY FOOD SYSTEMS, HOUSING ITS APPLIED RESEARCH AND DEMONSTRATION PROGRAMS STAFF AND PROVIDING SPACE FOR MEETINGS, FORUMS AND CONFERENCES. ENHANCING FOOD SAFETY, NUTRITION AND HEALTH: WITHIN THIS AREA BOTH RESEARCH AND EXTENSION WILL WORK TO ADDRESS THE ISSUE OF HUMAN HEALTH, FOOD SAFETY AND HEALTHY LIVING HABITS. THE RESEARCH WILL FOCUS ON WHOLE GRAIN CEREALS, HUMAN HEALTH AND HUMAN NUTRITION, PROBIOTICS STRAINS, FOOD ALLERGY, FOOD PRODUCTION PROCESS, BIOACTIVE COMPOUNDS OF FOOD, POSTHARVEST TECHNOLOGY AND FOOD SECURITY. COOPERATIVE EXTENSION AND RESEARCHERS AT NCA<(>&<)>T WILL WORK TOGETHER IN A CONCERTED EFFORT TO INCREASE INFORMATION AND RESOURCES FOR AFRICAN AMERICAN FAMILIES AND CHILDREN IN RURAL COMMUNITIES WHO ARE OFTEN POOR AND DISPROPORTIONATELY AFFLNERABLE ARE WELL EQUIPPED TO MAKE SOUND FINANCIAL DECISIONS FOR THEMSELVES AND THEIR FAMILIES. 4-H PROGRAMMING WILL FOCUS ON AREAS SUCH AS STEM (SCIENCE, TECHNOLOGY, ENGINEERING, AND MATH), LEADERSHIP DEVELOPMENT, AND AGRISCIENCE. INNOVATION STATION, THE CUTTING-EDGE MOBILE LEARNING EXPERIENCE, WILL CONTINUE TRAVELING TO COUNTIES THROUGHOUT NORTH CAROLINA, PROVIDING INTRODUCTORY AND ADVANCED STEM CURRICULA FOR CHILDREN IN GRADES K-12. ENVIRONMENTAL AND NATURAL RESOURCES: IN THIS AREA WE WILL WORK TO PROTECT THE NATURAL ENVIRONMENT, PROVIDE THE SOLUTION FOR WASTE MA NAGEMENT AND CONVENTIONAL ENERGY. CAES RESEARCHERS WILL INVESTIGATE AN ADVANCED BIOLOGICAL SYSTEM TO PRODUCE ALTERNATIVE ENERGY, TREAT THE AGRICULTURAL AND INDUSTRIAL WASTE, AND PROTECT AND IMPROVE WATER QUALITY. CAES RESEARCHERS WILL BE INVOLVED IN MULTISTATE CLIMATE CHANGE PROJECT TO STUDY THE IMPACT OF CLIMATE CHANGE IN SOCIALLY DISADVANTAGED FARMERS AND COMMUNITY OF COLOR. RESEARCHERS WILL BE DEVELOPING THE ADAPTATIONAND MITIGATION SOLUTION TO IMPROVE AGRICULTURE AND NATURAL RESOURCES AND WILL BE PROPOSING POLICIES TO ADDRESS THE ISSUE OF ENVIRONMENTAL JUSTICE AND CLIMATE CHANGE. EXTENSION WILL CONTINUE TO SUPPORT SMALL SCALE PRODUCERS AND LANDOWNERS IN THEIR EFFORT TO DEVELOP WOODLOT MANAGEMENT PLANS WHILE ALSO INTEGRATING TECHNIQUES AND PRACTICES SUCH AS SILVOPASTURE PRODUCTION AND RIPARIAN BUFFERS.

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS

2019 HATCH ACT OF 1887 (REGULAR RESEARCH)

THROUGH INTEGRATED RESEARCH AND EXTENSION PROGRAMS, NC STATE IS SOLVING CHALLENGES RELATED TO THE PRODUCTIVITY AND PROFITABILITY OF BOTH LARGE- AND SMALL-SCALE FARMS. RESEARCHERS AND EXTENSION EDUCATORS ARE ALSO DEVELOPING AND DISSEMINATING KNOWLEDGE AND TECHNOLOGY TO IMPROVE LANDSCAPING AND GARDENING. RESEARCH AND EXTENSION PROGRAMS IN ANIMAL SYSTEMS ARE FOCUSED ON DEVELOPING AND DISSEMINATING KNOWLEDGE AND METHODS FOR ANIMAL BREEDING, REPRODUCTION, NUTRITION, GENETICS AND GENOMICS, PHYSIOLOGY, ENVIRONMENTAL STRESS, PRODUCT QUALITY, AND HEALTH AND WELL-BEING. THESE INTEGRATED RESEARCH AND EXTENSION EFFORTS ALSO AIM TO TACKLE THE CRITICAL ISSUES IMPACTING THE QUALITY OF OUR SOIL, WATER AND AIR BY PROVIDING SCIENTIFIC SOLUTIONS FOR ANIMAL WASTE MANAGEMENT, WASTEWATER TREATMENT, NUTRIENT MANAGEMENT, SEPTIC SYSTEMS, WETLAND MANAGEMENT, SOIL PROPERTIES, AND FISHERY AND POND MANAGEMENT. NC STATE'S RESEARCH AND EXTENSION EFFORTS TO ENHANCE FOOD SAFETY, NUTRITION AND HEALTH AND TO KEEP AMERICAN'S HEALTHY AND FREE FROM FOODBORNE ILLNESS NECESSITATE A FOCUS ON PREVENTING FOOD SAFETY PROBLEMS RATHER THAN TAKING A REACTIONARY APPROACH. NC STATE'S INTEGRATED RESEARCH AND EXTENSION EFFORTS FOCUS ON PROTECTING THE SAFETY OF FOODS ALONG THE ENTIRE SUPPLY CHAIN, FROM PRODUCTION TO CONSUMPTION. TO MEET THE GROWING NEED FOR HEALTHY FOOD, RESEARCHERS ARE DEVELOPING AND PRODUCING NEW FOOD PRODUCTS THAT PROMOTE HEALTH AND PREVENT DISEASE. AT THE SAME TIME, EXTENSION PROVIDES NUTRITION EDUCATION PROGRAMMING TO ENSURE THAT INDIVIDUALS, FAMILIES, AND COMMUNITIES HAVE THE KNOWLEDGE THEY NEED TO MAKE INFORMED CHOICES ABOUT FOOD AND HEALTHY LIFESTYLES. IMPROVING PLANT AND ANIMAL AGRICULTURAL SYSTEMS: WITHIN THIS AREA, WE WILL WORK TO ADDRESS CROSS-CUTTING AND EMERGING ISSUES OF ANIMAL AND PLANT HEALTH AND PRODUCTION. IN ANIMAL SYSTEMS, RESEARCHERS WILL STUDY THE EFFICIENCY OF DIFFERENT FEEDING SOURCES TO IMPROVE ANIMAL PRODUCTIVITY AND GUT HEALTH. IN PLANT SYSTEMS, THE FOCUS WILL BE IN SUSTAINABLE AGRICULTURE, ALTERNATIVE AND HIGH VALUE CROP PRODUCTION, SEASON EXTENSION, CLIMATE CHANGE ADAPTATION, VALUE ADDED AGRICULTURE, DIGITAL AGRICULTURE, SOIL HEALTH, PEST CONTROL, AND AGRO ECONOMICS. EXTENSION WILL CONTINUE TO EXPAND ITS WORK WITH LIVESTOCK PRODUCERS, PLACING SPECIAL EMPHASIS ON LIMITED RESOURCES, SMALL- SCALE MINORITY FARMERS. THE FARM PAVILION WILL FOCUS ON SUSTAINABLE AGRICULTURE AND LOCAL AND COMMUNITY FOOD SYSTEMS, HOUSING ITS APPLIED RESEARCH AND DEMONSTRATION PROGRAMS' STAFF AND PROVIDING SPACE FOR MEETINGS, FORUMS AND CONFERENCES.

2020 HATCH ACT OF 1887 (REGULAR RESEARCH)

2022 HATCH ACT OF 1887

THROUGH INTEGRATED RESEARCH AND EXTENSION PROGRAMS, NC STATE IS SOLVING CHALLENGES RELATED TO THE PRODUCTIVITY AND PROFITABILITY OF BOTH LARGE- AND SMALL-SCALE FARMS. RESEARCHERS AND EXTENSION EDUCATORS ARE ALSO DEVELOPING AND DISSEMINATING KNOWLEDGE AND TECHNOLOGY TO IMPROVE LANDSCAPING AND GARDENING. RESEARCH AND EXTENSION PROGRAMS IN ANIMAL SYSTEMS ARE FOCUSED ON DEVELOPING AND DISSEMINATING KNOWLEDGE AND METHODS FOR ANIMAL BREEDING, REPRODUCTION, NUTRITION, GENETICS AND GENOMICS, PHYSIOLOGY, ENVIRONMENTAL STRESS, PRODUCT QUALITY, AND HEALTH AND WELL-BEING. THESE INTEGRATED RESEARCH AND EXTENSION EFFORTS ALSO AIM TO TACKLE THE CRITICAL ISSUES IMPACTING THE QUALITY OF OUR SOIL, WATER AND AIR BY PROVIDING SCIENTIFIC SOLUTIONS FOR ANIMAL WASTE MANAGEMENT, WASTEWATER TREATMENT, NUTRIENT MANAGEMENT, SEPTIC SYSTEMS, WETLAND MANAGEMENT, SOIL PROPERTIES, AND FISHERY AND POND MANAGEMENT. NC STATE'S RESEARCH AND EXTENSION EFFORTS TO ENHANCE FOOD SAFETY, NUTRITION AND HEALTH AND TO KEEP AMERICAN'S HEALTHY AND FREE FROM FOODBORNE ILLNESS NECESSITATE A FOCUS ON PREVENTING FOOD SAFETY PROBLEMS RATHER THAN TAKING A REACTIONARY APPROACH. NC STATE'S INTEGRATED RESEARCH AND EXTENSION EFFORTS FOCUS ON PROTECTING THE SAFETY OF FOODS ALONG THE ENTIRE SUPPLY CHAIN, FROM PRODUCTION TO CONSUMPTION. TO MEET THE GROWING NEED FOR HEALTHY FOOD, RESEARCHERS ARE DEVELOPING AND PRODUCING NEW FOOD PRODUCTS THAT PROMOTE HEALTH AND PREVENT DISEASE. AT THE SAME TIME, EXTENSION PROVIDES NUTRITION EDUCATION PROGRAMMING TO ENSURE THAT INDIVIDUALS, FAMILIES, AND COMMUNITIES HAVE THE KNOWLEDGE THEY NEED TO MAKE INFORMED CHOICES ABOUT FOOD AND HEALTHY LIFESTYLES. IMPROVING PLANT AND ANIMAL AGRICULTURAL SYSTEMS: WITHIN THIS AREA, WE WILL WORK TO ADDRESS CROSS-CUTTING AND EMERGING ISSUES OF ANIMAL AND PLANT HEALTH AND PRODUCTION. IN ANIMAL SYSTEMS, RESEARCHERS WILL STUDY THE EFFICIENCY OF DIFFERENT FEEDING SOURCES TO IMPROVE ANIMAL PRODUCTIVITY AND GUT HEALTH. IN PLANT SYSTEMS, THE FOCUS WILL BE IN SUSTAINABLE AGRICULTURE, ALTERNATIVE AND HIGH VALUE CROP PRODUCTION, SEASON EXTENSION, CLIMATE CHANGE ADAPTATION, VALUE ADDED AGRICULTURE, DIGITAL AGRICULTURE, SOIL HEALTH, PEST CONTROL, AND AGRO ECONOMICS. EXTENSION WILL CONTINUE TO EXPAND ITS WORK WITH LIVESTOCK PRODUCERS, PLACING SPECIAL EMPHASIS ON LIMITED RESOURCES, SMALL- SCALE MINORITY FARMERS. THE FARM PAVILION WILL FOCUS ON SUSTAINABLE AGRICULTURE AND LOCAL AND COMMUNITY FOOD SYSTEMS, HOUSING ITS APPLIED RESEARCH AND DEMONSTRATION PROGRAMS' STAFF AND PROVIDING SPACE FOR MEETINGS, FORUMS AND CONFERENCES.

2021 HATCH ACT OF 1887 (REGULAR RESEARCH)

THROUGH INTEGRATED RESEARCH AND EXTENSION PROGRAMS, NC STATE IS SOLVING CHALLENGES RELATED TO THE PRODUCTIVITY AND PROFITABILITY OF BOTH LARGE- AND SMALL-SCALE FARMS. RESEARCHERS AND EXTENSION EDUCATORS ARE ALSO DEVELOPING AND DISSEMINATING KNOWLEDGE AND TECHNOLOGY TO IMPROVE LANDSCAPING AND GARDENING. RESEARCH AND EXTENSION PROGRAMS IN ANIMAL SYSTEMS ARE FOCUSED ON DEVELOPING AND DISSEMINATING KNOWLEDGE AND METHODS FOR ANIMAL BREEDING, REPRODUCTION, NUTRITION, GENETICS AND GENOMICS, PHYSIOLOGY, ENVIRONMENTAL STRESS, PRODUCT QUALITY, AND HEALTH AND WELL-BEING. THESE INTEGRATED RESEARCH AND EXTENSION EFFORTS ALSO AIM TO TACKLE THE CRITICAL ISSUES IMPACTING THE QUALITY OF OUR SOIL, WATER AND AIR BY PROVIDING SCIENTIFIC SOLUTIONS FOR ANIMAL WASTE MANAGEMENT, WASTEWATER TREATMENT, NUTRIENT MANAGEMENT, SEPTIC SYSTEMS, WETLAND MANAGEMENT, SOIL PROPERTIES, AND FISHERY AND POND MANAGEMENT. NC STATE'S RESEARCH AND EXTENSION EFFORTS TO ENHANCE FOOD SAFETY, NUTRITION AND HEALTH AND TO KEEP AMERICAN'S HEALTHY AND FREE FROM FOODBORNE ILLNESS NECESSITATE A FOCUS ON PREVENTING FOOD SAFETY PROBLEMS RATHER THAN TAKING A REACTIONARY APPROACH. NC STATE'S INTEGRATED RESEARCH AND EXTENSION EFFORTS FOCUS ON PROTECTING THE SAFETY OF FOODS ALONG THE ENTIRE SUPPLY CHAIN, FROM PRODUCTION TO CONSUMPTION. TO MEET THE GROWING NEED FOR HEALTHY FOOD, RESEARCHERS ARE DEVELOPING AND PRODUCING NEW FOOD PRODUCTS THAT PROMOTE HEALTH AND PREVENT DISEASE. AT THE SAME TIME, EXTENSION PROVIDES NUTRITION EDUCATION PROGRAMMING TO ENSURE THAT INDIVIDUALS, FAMILIES, AND COMMUNITIES HAVE THE KNOWLEDGE THEY NEED TO MAKE INFORMED CHOICES ABOUT FOOD AND HEALTHY LIFESTYLES. IMPROVING PLANT AND ANIMAL AGRICULTURAL SYSTEMS: WITHIN THIS AREA, WE WILL WORK TO ADDRESS CROSSCUTTING AND EMERGING ISSUES OF ANIMAL AND PLANT HEALTH AND PRODUCTION. IN ANIMAL SYSTEMS, RESEARCHERS WILL STUDY THE EFFICIENCY OF DIFFERENT FEEDING SOURCES TO IMPROVE ANIMAL PRODUCTIVITY AND GUT HEALTH. IN PLANT SYSTEMS, THE FOCUS WILL BE ON PRACTICAL APPROACHES SUCH AS CROP PRODUCTION, SEASON EXTENSION, ADAPTATION TO CHANGING AGRICULTURAL CONDITIONS, VALUE-ADDED AGRICULTURE, DIGITAL TOOLS, SOIL HEALTH, PEST CONTROL, AND FARM ECONOMICS. EXTENSION WILL CONTINUE TO EXPAND ITSWORK WITH LIVESTOCK PRODUCERS, PLACING SPECIAL EMPHASIS ON LIMITED RESOURCES, SMALL- SCALE FARMERS.THE FARM PAVILION WILL FOCUS ON SUSTAINABLE AG RICULTURE AND LOCAL ANDCOMMUNITY FOOD SYSTEMS, HOUSING ITS APPLIED RESEARCH AND DEMONSTRATION PROGRAMS' STAFF AND PROVIDING SPACE FOR MEETINGS, FORUMS AND CONFERENCES.

THE PURPOSE OF THIS AGREEMENT IS TO SUPPORT THE GOAL OF PREVENTING THE ENTRY AND SPREAD OF AGRICULTURAL PESTS AND PATHOGENS IN THE UNITED STATES AND FACILITATING SAFE TRADE BY DEVELOPING PEST RISK ANALYSIS PRODUCTS THAT SUPPORT PPQ.

FOGARTY GLOBAL HEALTH FELLOWS COORDINATING CENTER

THE HATCH ACT OF 1887 (REGULAR RESEARCH)

THIS PROJECT WILL ESTABLISH A NATIONWIDE COORDINATED TRANSDISCIPLINARY RESEARCH APPROACH TO DEVELOP AND IMPLEMENT MARKER ASSISTED SELECTION (MAS) CAPACITY IN VACCINIUM BREEDING PROGRAMS, TO ENABLE BREEDERS TO SELECT AND PYRAMID FRUIT CHARACTERISTICS (FCS) THAT POSITIVELY CONTRIBUTE TO FRUIT QUALITY AND MARKET VALUE. VACCINIUM CROPS (BLUEBERRY AND CRANBERRY) PROVIDES VITAL CONTRIBUTIONS TO HUMAN HEALTH AND WELL-BEING, AND COLLECTIVELY CONSTITUTES THE ECONOMIC BACKBONE OF MANY U.S. RURAL COMMUNITIES. VACCINIUM GENETIC AND GENOMIC RESOURCES ARE DEVELOPING RAPIDLY BUT HAVE NOT BEEN TRANSLATED TO ROUTINE PRACTICAL APPLICATION. SPECIFIC OBJECTIVES ARE TO: (1) ESTABLISH A COST EFFECTIVE GENOTYPING PLATFORM TO EXPAND MARKER-TRAIT ASSOCIATION ANALYSIS (MTA) IN VACCINIUM, EXPLOITING THE SHARED ANCESTRY OF VACCINIUM CROPS; (2) IDENTIFY DNA MARKERS LINKED TO FRUIT CHARACTERISTICS AND ELUCIDATE HOW AND WHICH FRUIT CHARACTERISTICS AFFECT FRUIT QUALITY, RELATIVE TO CONSUMER PREFERENCES, DECAY DURING MECHANICAL HARVEST, PROCESSING AND DISTRIBUTION; (3) DEVELOP DNA ASSAYS TO IMPLEMENT MAS IN CORE VACCINIUM CORE BREEDING PROGRAMS WITH A COMMON FOCUS ON FRUIT QUALITY TRAITS; (4) ENLARGE MARKET POTENTIAL, AND INCREASE CONSUMPTION OF VACCINIUM FRUITS BY USING SOCIO-ECONOMIC KNOWLEDGE OF CONSUMER PREFERENCES TO INFORM BREEDING; AND (5) ENHANCE SUSTAINABILITY OF CULTIVAR DEVELOPMENT BY TRANSFERRING MAS TECHNOLOGIES TO PUBLIC AND PRIVATE U.S. VACCINIUM BREEDING PROGRAMS THROUGH TRAINING CURRENT AND FUTURE BREEDERS AS WELL AS ENGAGING THE PRODUCTION, DISTRIBUTION, PROCESSING AND MARKETING SECTORS, ALLIED SCIENTISTS, AND CONSUMERS. THIS COORDINATED AGRICULTURAL PROJECT PROPOSAL ADDRESSES SCRI FOCUS AREA 1 (70%) AND FOCUS AREA 2 (30%).

THE HATCH ACT OF 1887 (REGULAR RESEARCH)

2018 HATCH ACT OF 1887 (REGULAR RESEARCH)

2017 HATCH ACT OF 1887 (REGULAR RESEARCH)

SWINE BIOMEDICAL RESEARCH FACILITY FOR GNOTOBIOTIC, TRANSGENIC AND TRANSLATIONAL MEDICINE - THE OVERALL GOAL OF THIS PROJECT IS TO DESIGN, CONSTRUCT AND OUTFIT A SWINE BIOMEDICAL RESEARCH FACILITY ON THE CAMPUS OF THE FOURTH RANKED COLLEGE OF VETERINARY MEDICINE IN THE UNITED STATES WITH READY ACCESS TO TRAINED VETERINARY SPECIALISTS AND STATE OF THE ART BIOMEDICAL (E.G. MRI, CT AND NUCLEAR MEDICINE) FACILITIES. THE FACILITY WILL PROVIDE ADDITIONAL HIGH-QUALITY SPACE FOR BIOMEDICAL RESEARCH BY NIH FUNDED FACULTY FROM NC STATE UNIVERSITY, DUKE UNIVERSITY AND THE UNIVERSITY OF NORTH CAROLINA. THE DESIGN AND CONSTRUCTION OF THE SWINE BIOMEDICAL RESEARCH FACILITY WILL FEATURE A FREE-STANDING MASONRY AND STEEL BUILDING THAT WILL HOUSE THE PRODUCTION AND CARE OF GNOTOBIOTIC AND GENE-EDITED SWINE, AS WELL AS STATE-OF-THE-ART PROCEDURES (SURGICAL, TELEMETRY, ARTHROSCOPY, ENDOSCOPY). IN ADDITION, THE UNIT INCLUDES FLEXIBLE SPACE THAT CAN ACCOMMODATE PREGNANT AND NON-PREGNANT SOWS, AND FARROWING FACILITIES TO GENERATE NEEDED GENE EDITED PROGENY FROM OUR OWN LINES AS WELL AS THOSE OBTAINED FROM THE NIH-SUPPORTED NSRRC. PROCEDURAL SPACE WILL PROVIDE A STERILE SURGERY SUITE (TWO TABLES) TO ACCOMMODATE AN INCREASING BIOENGINEERING NEED FOR ENDOSCOPIC AND ARTHROSCOPIC PROCEDURES. THE BUILDING WILL BE PLACED IMMEDIATELY ADJACENT TO SPACE (REFERRED TO AS THE G20 FACILITY) PREVIOUSLY CREATED FOR THE USE OF SEVERE COMBINED IMMUNODEFICIENCY AND OTHER GENE EDITED MINIATURE OR JUVENILE PIGS (G20 OD020279) TO ALLOW FOR SHARED USE OF THE SPACE WHEN POSSIBLE. THE PROPOSED FACILITY HAS BEEN DESIGNED TO MAXIMIZE SYNERGY AND MINIMIZE OVERLAP WITH THE G20 SPACE. COMBINED THEY WILL GIVE US A HIGH DEGREE OF FLEXIBILITY AND WILL ALLOW US TO CONDUCT A BROAD RANGE OF RESEARCH THUS HAVING A BROAD IMPACT ACROSS MULTIPLE NIH CENTERS/INSTITUTES. THIS PROJECT TEAM IS UNIQUELY SITUATED TO DRIVE THE DESIGN AND DEVELOPMENT OF THIS FACILITY AND THE EXPANSION OF THIS PROGRAM. BY SERVING IN LEADERSHIP ROLES WITHIN THE COLLEGE OF VETERINARY MEDICINE AND NC STATE UNIVERSITY WE HAVE THE ABILITY TO PROVIDE ACCESS TO THE VETERINARY COLLEGE BIOMEDICAL CAMPUS, THE RESEARCH ANIMAL FACILITIES AND THE STATE-OF-THE-ART EQUIPMENT IN THE TERTIARY CARE VETERINARY HOSPITAL. OUR TEAM OF INVESTIGATORS HAS COMPARATIVE MEDICINE EXPERTISE AND AN EXTENSIVE COLLABORATIVE NETWORK WITH BIOMEDICAL RESEARCHERS AT DUKE AND THE UNIVERSITY OF NORTH CAROLINA. AS A TEAM, WE HAVE SUCCESSFULLY MANAGED INFRASTRUCTURE GRANTS, SUCH AS THE EXPANSION OF FACILITIES FOR HOUSING AND STUDYING TRANSGENIC AND NON-TRANSGENIC MINIATURE PIGS (G20 OD020279) AND BUILDING PROJECTS INCLUDING A 20,000 SQUARE FOOT WET LAB AND GMP LAB SPACE.

MULTI-MODAL ENERGY FLOW AT ATOMICALLY ENGINEERED INTERFACES

PROJECT ABSTRACT SUMMARY NOW IN ITS SIXTH DECADE, NORTH CAROLINA SEA GRANT CONNUES TO FACILITATE, CONDUCT AND DELIVER RESPONSIVE RESEARCH, EXTENSION AND OUTREACH PROGRAMMING THAT ADDRESSES THE SHORT AND LONG TERM IDENED NEEDS OF COASTAL NORTH CAROLINA, THE REGION AND NAON. IN ALIGNMENT WITH NORTH CAROLINA SEA GRANT'S 20242027 STRATEGIC PLAN, THIS PROPOSAL REECTS THE PROGRAM'S LONGSTANDING ABILITY, COMMITMENT, AND WILLINGNESS TO LEAD EORTS TO SEEK SOLUONS TO ISSUES HERE IN OUR STATE. OUR PROGRAMMING DIRECTLY ADDRESSES CURRENT, AND FUTURE IDENED PRIORIES, BASED ON INTERNAL EXPERIENCE AND EXPERSE, EXTERNAL ADVISORY BOARD INPUT, AND REGULAR STAKEHOLDER ENGAGEMENT ACROSS OUR COAST AND COASTAL WATERSHEDS. NC SEA GRANT'S PROGRAM MANAGEMENT INCLUDES TALENTED INDIVIDUALS LEADING THE PROGRAM'S EXTENSION, RESEARCH, COMMUNICAONS AND SCAL TEAMS, WITH STRONG INTEGRAON AND ENGAGEMENT ACROSS THE MORE THAN 25 TEAM MEMBERS AND STUDENT INTERNS. TEAM MEMBERS ARE COLOCATED WITH THE PROGRAM'S HOST INSTUON, NORTH CAROLINA STATE UNIVERSITY IN RALEIGH, AS WELL AS AT THE UNIVERSITY OF NORTH CAROLINA WILMINGTON'S CENTER FOR MARINE SCIENCE IN THE SOUTHERN COAST AREA, NC STATE'S CENTER FOR MARINE SCIENCE AND TECHNOLOGY IN THE CENTRAL COAST AREA OF MOREHEAD, AND NALLY IN THE NORTHERN COAST AT EAST CAROLINA UNIVERSITY'S COASTAL STUDIES INSTUTE IN WANCHESE. NC SEA GRANT SEEKS TO INCREASE OVERALL PROGRAM IMPACTS THROUGH LEVERAGED FUNDING AND STRATEGIC PARTNERSHIPS. PROPOSED EORTS DIRECTLY ALIGN WITH THE FOUR FOCUS AREAS FULLY DESCRIBED IN NORTH CAROLINA SEA GRANT'S 20242027 STRATEGIC PLAN: ENVIRONMENTAL LITERACY AND WORKFORCE DEVELOPMENT, HEALTH COASTAL ECOSYSTEMS, SUSTAINABLE FISHERIES AND AQUACULTURE, AND RESILIENT COMMUNIES AND ECONOMIES. THESE AREAS ALIGN DIRECTLY WITH THE NOAA SEA GRANT STRATEGIC PLAN. THE MANAGEMENT, COMMUNICAONS, EXTENSION, EDUCAON AND RESEARCH PROJECTS DESCRIBED IN THIS OMNIBUS CLEARLY EMBRACE OUR COLLABORAVE APPROACH TO PROGRAM EXECUON. THE PROPOSAL PROVIDES CRICAL INVESTMENTS IN OUR TEAM MEMBERS, WHO PROVIDE THE BASE OF SUCCESS IN PARTNERSHIP DEVELOPMENT, RESEARCH, EXTENSION AND COMMUNICAON EXCELLENCE. PROJECTS AND ACVIES DESCRIBED ARE AT THE INTERSECON OF RESEARCH, EDUCAON AND OUTREACH, WITH INDIVIDUALS COMMIED TO ENSURING WORK IS TRANSLATED TO ACONABLE INFORMAON IN SUPPORT OF THE VARIED STAKEHOLDERS INVESTED IN THE STATE'S COASTAL REGION. COMPEVE RESEARCH PROJECTS FOCUS ON HIGHPRIORITY, OEN INNOVAVE, EORTS THAT REQUIRE NOT ONLY EXPERSE FROM ACROSS THE STATE'S EXCELLENT PUBLIC AND PRIVATE INSTUONS BUT ALSO A RANGE OF SKILLS AND CAPACITY FROM COMMUNITY NONPROT, INDUSTRY, STATE GOVERNMENT, AND FEDERAL PARTNERS. THE BREADTH AND DEPTH OF PROPOSED RESEARCH, EXTENSION AND OUTREACH WORK RANGES FROM INDIVIDUAL COMMUNITY MEMBER SUPPORT ON SITESPECIC NEEDS, TO STATE AND NAONALLEVEL COLLABORAONS THAT ADDRESS LARGER SCALE CHALLENGES AND OPPORTUNIES FACED BY OUR NAON'S COASTAL COMMUNIES. NC SEA GRANT'S STRONG COMMUNICAON STRATEGIES AND ROBUST RANGE OF COMMUNICAON PRODUCTS ENSURE PROJECT NDINGS AND PROGRAM MESSAGES REACH TARGETED AUDIENCES ACROSS THE STATE, REGION AND NAON IN BOTH PRINT AND ONLINE MEDIA PLAORMS.

(MURI) ELUCIDATING INTERPLAYS OF CHIRALITY AND SPIN IN CHIRAL ASSEMBLIES

HIGH GROWTH

NUCLEAR THEORY AT NORTH CAROLINA STATE UNIVERSITY

HYDROGEN-DEPENDENT CONVERSION OF CARBON DIOXIDE TO LIQUID ELECTROFUELS BY EXTREMELY THERMOPHILIC ARCHAEA

THE HATCH ACT OF 1887 (REGULAR RESEARCH)

SMITH LEVER 3B&C FUNDS

SMITH LEVER 3B&C FUNDS

NNCI: NORTH CAROLINA RESEARCH TRIANGLE NANOTECHNOLOGY NETWORK (RTNN)

PROJECT TITLE: HOSTING THE SOUTHEAST CLIMATE ADAPTATION SCIENCE CENTER (SE CASC)PROJECT DATES: 8 1 2023 THROUGH 7 31 2028AWARD PURPOSE: THE PURPOSE OF THIS PROPOSAL IS TO HOST THE SOUTHEAST CLIMATE ADAPTATION SCIENCE CENTER (SE CASC). THE SE CASC CONSORTIUM CONSISTS OF ELEVEN INSTITUTIONS SPANNING SIX LAND GRANT UNIVERSITIES, THREE HISTORICALLY BLACK MINORITY SERVING UNIVERSITIES, A NATIONALLY RECOGNIZED SCIENCE POLICY CENTER, AN ENVIRONMENTAL JUSTICE CENTER, AND AN INTERTRIBAL ORGANIZATION REPRESENTING SOUTHERN EASTERN TRIBAL NATIONS. THIS CONSORTIUM OFFERS UNPARALLELED EXPERTISE IN COPRODUCING ACTIONABLE ADAPTATION SCIENCE ACROSS THE PHYSICAL, NATURAL, AND SOCIAL SCIENCES.ACTIVITIES TO BE PERFORMED: THE CONSORTIUM WILL ADDRESS THE SCIENCE PRIORITIES OF THE REGION THROUGH RESEARCH AND SYNTHESIS PROJECTS CO-PRODUCED WITH A DIVERSITY OF PARTNERS AND CONDUCT FORMAL EVALUATION OF PRODUCTS AND THEIR UTILITY. A GOVERNANCE COMMITTEE WILL LEAD SCIENCE, CAPACITY BUILDING, AND COMMUNICATION ACROSS THE SOUTHEAST AND CARIBBEAN FOOTPRINT. RECIPIENT STAFF WILL MEET WITH FEDERAL PARTNERS IN WEEKLY, MONTHLY, QUARTERLY, AND ANNUAL MEETINGS. REGIONAL DIALOGUE WILL BE FOSTERED THROUGH TWO REGIONAL CLIMATE ADAPTATION SCIENCE SYMPOSIA AND REGULAR PARTICIPATION IN MEETINGS OF PARTNERS, INCLUDING THE HBCU CLIMATE CHANGE CONFERENCE. THE RECIPIENT WILL BUILD A ROBUST PORTFOLIO OF RESOURCES AND ACTIVITIES TO BUILD CAPACITY FOR CLIMATE ADAPTATION FOR NATURAL AND CULTURAL RESOURCE PARTNERS, GRADUATE STUDENTS, AND OTHER EARLY CAREER PROFESSIONAL RESEARCHERS, WITH TARGETED EFFORTS TO FOSTER ENGAGEMENT OF TRIBES, INDIGENOUS PEOPLES, AND OTHER COMMUNITIES HISTORICALLY UNDERREPRESENTED IN CLIMATE SCIENCE AND ADAPTATION. THE SE CASC COMMUNICATIONS STRATEGY WILL USE MULTIPLE FORMS OF MEDIA ENGAGEMENT TO REACH ACROSS MULTIPLE SECTORS OF END USERS AND ACROSS A DIVERSE FOOTPRINT. FINALLY, THE HOST UNIVERSITY WILL MANAGE THE LARGE AND COMPLEX FUNDING OF SUBAWARD PARTNERS ASSOCIATED WITH THIS FEDERAL-UNIVERSITY PARTNERSHIP, INCLUDING THE HOST (PRIME) AWARD AND DIRECTED PROJECT FUNDING.DELIVERABLES AND EXPECTED OUTCOMES:THE RECIPIENT WILL: (1) DEVELOP A CONSORTIUM THAT REACHES ACROSS THE SOUTHEAST AND CARIBBEAN FOOTPRINT, AND FACILITATE CONVERSATIONS AMONG DECISION MAKERS, SCIENTISTS, AND MANAGERS (2) CONDUCT CO-PRODUCED AND ACTIONABLE RESEARCH AND SYNTHESIS THROUGH PROJECTS THAT PROVIDE DECISION-FOCUSED, RESEARCH-BASED INFORMATION MEETING REGIONAL SCIENCE PRIORITIES (3) BUILD CAPACITY OF NATURAL AND CULTURAL RESOURCE PROFESSIONALS, GRADUATE RESEARCH STUDENTS, SCIENCE COMMUNICATIONS INTERNS AND OTHER YOUNG PROFESSIONALS IN HOW TO FRAME, UNDERSTAND, AND SUPPORT CLIMATE ADAPTATION DECISIONS, VIA RESEARCH ENGAGEMENT EFFORTS (4) COMMUNICATE THE PRODUCTS CREATED FOR CLIMATE ADAPTATION THROUGH DIVERSE MEDIA AND VENUES AND FOR MANY AUDIENCES (5) ENGAGE TRIBES, INDIGENOUS PEOPLES, AND OTHER HISTORICALLY UNDERREPRESENTED COMMUNITIES IN CLIMATE RESEARCH, SYNTHESIS, AND CAPACITY BUILDING (6) PROVIDE FISCAL MANAGEMENT OF AWARD FUNDING.INTENDED BENEFICIARY(IES): TARGET AUDIENCES INCLUDE RELEVANT FEDERAL AGENCIES, STATE AGENCIES, LOCAL GOVERNMENTS, TRIBAL NATIONS AND INDIGENOUS PEOPLES, LOCAL COMMUNITIES INCLUDING HISTORICALLY UNDERREPRESENTED AND UNDERSERVED COMMUNITIES, NON-GOVERNMENTAL ORGANIZATIONS, BUSINESSES, RESEARCHERS AND EDUCATORS, AND THE GENERAL PUBLIC.SUBRECIPIENT ACTIVITIES: SUBRECIPIENTS WILL BE FULLY INTEGRATED INTO ALL CONSORTIUM ACTIVITIES INCLUDING LEADERSHIP, RESEARCH AND SYNTHESIS, CAPACITY BUILDING, AND COMMUNICATIONS. SUBAWARD PARTNERS INCLUDE: AUBURN UNIVERSITY, DUKE UNIVERSITY, SAVANNAH STATE UNIVERSITY, UNIVERSITY OF FLORIDA, UNIVERSITY OF SOUTH CAROLINA, UNIVERSITY OF TENNESSEE, AND UNIVERSITY OF THE VIRGIN ISLANDS.

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SOUTHERN IPM CENTER: A REGIONAL APPROACH TO NETWORKING, COLLABORATION AND SERVICES

ELIMINATING DISPARITIES IN PERINATAL HEALTH

SPATIO-TEMPORAL DYNAMICS OF GEF-GTPASE NETWORKS

NNCI: NORTH CAROLINA RESEARCH TRIANGLE NANOTECHNOLOGY NETWORK (RTNN)

MULTI UNIVERSITY SOUTHEAST INIE (INNOVATIONS IN NUCLEAR INFRASTRUCTURE AND EDUCATION PROGRAM) CONSORTIUM

THE BROWN MARMORATED STINK BUG (BMSB) IS AN INVASIVE INSECT THAT FIRST APPEARED AS A SEVERE ECONOMIC PEST OF SPECIALTY CROPS IN THE MID-ATLANTIC IN 2010. IT HAS SINCE SPREAD TO 43 STATES AND IS NOW A THREAT TO SPECIALTY CROPS ACROSS MUCH OF THE US. A SCRI CAP (2011-2016) DEVELOPED CHEMICAL CONTROL STRATEGIES AND FUNDAMENTAL BIOLOGICAL AND ECOLOGICAL INFORMATION ON BMSB. WHILE THE CHEMICAL CONTROL COMPONENT PROVIDED SHORT-TERM RELIEF FOR PRODUCERS, RELIANCE ON BROAD SPECTRUM INSECTICIDES HAVE NEGATIVELY AFFECTED NON-TARGET ORGANISMS AND LED TO SECONDARY PEST OUTBREAKS. THIS PROJECT BUILDS UPON PREVIOUS FINDINGS, BUT RE-FOCUSES EFFORTS ON STAKEHOLDER-DRIVEN OBJECTIVES FOR LONG-TERM, SUSTAINABLE MANAGEMENT. THE PROJECT ADDRESSES SCRI GOALS ASSOCIATED WITH ASSRESSING THREASTS FROM PESTS, AND EFFORTS TO IMPROVE PRODUCTION EFFICIENCY. WE WILL IMPROVE OUR KNOWLEDGE OF BMSB RISK TO CROPS THROUGH ENHANCED UNDERSTANDING OF AGROECOLOGY AND LANDSCAPE ECOLOGY, IMPLEMENT WIDESPREAD BIOLOGICAL CONTROL OF BMSB WITH AN EXOTIC ASIAN PARASITOID AND NATIVE NATURAL ENEMIES, AND DEVELOP MANAGEMENT TOOLS AND STRATEGIES COMPATIBLE WITH BIOLOGICAL CONTROL AND INFORMED BY RISK FROM LANDSCAPE FACTORS. WE WILL CONTINUE TO DETERMINE THE ECONOMIC CONSEQUENCES OF BMSB DAMAGE AND HOW IT IS REDUCED BY SPECIFIC MANAGEMENT STRATEGIES, AND DELIVER SCIENCE-BASED INFORMATION WITH A ROBUST AND DIVERSIFIED OUTREACH PROGRAM BASED ON THE INFRASTRUCTURE DEVELOPED DURING THE FIRST SCRI PROJECT. THE NEW PROJECT IS NATIONAL IN SCOPE TO ADDRESS THE IMMINENT THREAT OF BMSB TO SPECIALTY CROPS IN REGIONS INVADED SINCE 2010 (SOUTHEAST, GREAT LAKES, PACIFIC NORTHWEST AND WEST), WHICH HAVE UNIQUE STAKEHOLDERS, CROPPING SYSTEMS AND LANDSCAPES.

NORTH CAROLINA SBDC

NORTH CAROLINA SBDC CARES ACT

SOUTHEAST CLIMATE SCIENCE CENTER

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE CAPACITY OF US OPEN-FIELD STRAWBERRY NURSERIES TO DEVELOP CLEAN PLANT MATERIAL IS CRUCIAL TO THE $2.8 BILLION STRAWBERRY PRODUCTION INDUSTRY. HOWEVER, DESPITE USING METHYL BROMIDE (MB) AS SOIL FUMIGANT, STRAWBERRY TRANSPLANTS SOLD TO FRUITING FIELDS FREQUENTLY ARE SYMPTOMLESS CARRIERS FOR A RANGE OF DEVASTATING DISEASES. THERE IS A CRITICAL NEED FOR THE STRAWBERRY NURSERY INDUSTRY TO DEVELOP NEW PROPAGATION TECHNOLOGY, TO MINIMIZE THE SPREAD OF PATHOGENS, FIND ALTERNATIVES TO MB AND EVENTUALLY REDUCE COST. IN THIS COORDINATED AGRICULTURAL PROJECT, WE PROPOSE TO ADDRESS THIS NEED BY DEVELOPING AND INTEGRATING CONTROLLED ENVIRONMENT (CE) STRAWBERRY PROPAGATION TECHNOLOGY. OUR APPROACH IS COLLABORATIVE AND HIGHLY INTEGRATED, AND WILL ENABLE INDUSTRY PARTNERS TO ADOPT AND USE CE PROPAGATION TECHNIQUES, EFFECTIVELY BROADEN THE TOOL-BOX AVAILABLE TO STRAWBERRY PROPAGATORS. WE EXTEND THE MISSION OF THE NATIONAL CLEAN PLANT NETWORK BY DEVELOPING TRANSFORMATIVE TECHNOLOGY THAT WILL LEAD TOLESS DISEASE TRANSMISSION THROUGH INFECTED PLANT MATERIAL AND THEREFORE HIGHER RESILIENCE OF THE ENTIRE STRAWBERRY SUPPLY CHAIN. OUR SPECIFIC OBJECTIVES ARE (1) DEVELOPING CE PROPAGATION TECHNOLOGY. (2) DEVELOP TRANSPLANT CONDITIONING AND LONG-TERM STORAGE PROTOCOLS. (3) DEVELOP GENETIC MATRIX TOOLS TO AID CE PROPAGATION TECHNOLOGY. (4) DETERMINE COST/RETURN OF DEVELOPED TECHNIQUES AND ANALYZE THE ECONOMIC IMPACT ON THE SUPPLY CHAIN. (5) TRANSLATION AND INTEGRATION OF CE PROPAGATION SYSTEMS WITH INDUSTRY PARTNERS. (6) EXTENSION AND OUTREACH ACTIVITIES. THE MAIN OUTCOME OF THIS PROJECT IS THE DEVELOPMENT OF COST-EFFECTIVE CE STRAWBERRY PROPAGATION TOOLS, ENABLING THE INDUSTRY TO REDUCED USE OF MB AND THE MITIGATION OF DISEASES AND PESTS

INNOVATING A COMMUNITY-BASED RESILIENCE MODEL ON CLIMATE AND HEALTH EQUITY IN THE CAROLINAS

IDENTIFYING BIOMARKERS FOR POST-PARTUM DEPRESSION IN AFRICAN-AMERICAN WOMEN

2015 HATCH ACT OF 1887 (REGULAR RESEARCH)

INITIATIVE FOR MAXIMIZING STUDENT DIVERSITY IN BIOMEDICAL AND BEHAVIORAL SCIENCES

2016 HATCH ACT OF 1887 (REGULAR RESEARCH)

VIPER: VIRAL INTERDICTION THROUGH POPULATION ENGINEERING AND RESTRUCTURING

STANDOFF INVERSE ANALYSIS AND MANIPULATION OF ELECTRONIC SYSTEMS

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SWEETPOTATOES ARE AN IMPORTANT SPECIALTY CROP IN THE SOUTHEASTERN US. HOWEVER, THE EMERGENCE OF THE ROOT-KNOT NEMATODE (RKN), MELOIDOGYNE ENTEROLOBII (ME) IN THE SOUTHEAST HAS CREATED AN INDUSTRY CRISIS. ME CAUSES SEVERE SWEETPOTATO YIELD LOSS AND IT HAS RESULTED IN CROP AND SEED QUARANTINES ACROSS THE US. IT IS ALSO A ZERO-TOLERANCE PEST IN EUROPE, WHICH ACCOUNTS FOR 18% OF THE US CROP SOLD. THERE ARE NO ACCEPTABLE ME RESISTANT VARIETIES AND GROWERS HAVE ADOPTED AGGRESSIVE SOIL FUMIGATION AND NEMATICIDE TREATMENTS TO REDUCE INFESTATIONS. CHEMICAL CONTROL FOR RKN IS NOT ECONOMICALLY SUSTAINABLE OR ENVIRONMENTALLY FRIENDLY. SUSTAINABLE SWEETPOTATO PEST MANAGEMENT REQUIRES A SYSTEMS-BASED APPROACH USING STRATEGIES INCLUDING TIMELY DIAGNOSTICS, CROP ROTATION, WEED MANAGEMENT, RESISTANT VARIETIES, ECONOMIC FORECASTING AND PRECISION PESTICIDE APPLICATIONS. THIS PROJECT INCORPORATES ALL OF THESE CONCEPTS IN A COMPREHENSIVE RESEARCH AND EXTENSION PROJECT THAT INTEGRATES SHORT-TERM OUTCOMES THAT RAPIDLY RESPOND TO THE EMERGING ME PEST ISSUE, WITH A LONGER-TERM GENOMIC-ASSISTED SWEETPOTATO BREEDING STRATEGY. OUR TEAM REPRESENTS LEADERS IN THEIR FIELDS WITH EXPERTISE IN BREEDING, GENOMICS/PHENOMICS, PLANT PATHOLOGY, CULTURAL MANAGEMENT, WEED SCIENCE, ECONOMICS AND EXTENSION. THE GOALS OF THE PROJECT ARE TO DEVELOP, IMPLEMENT, AND EVALUATE A SUSTAINABLE RKN MANAGEMENT PROGRAM IN SWEETPOTATO THAT CAN BE USED AS A MODEL IN OTHER VULNERABLE US SPECIALTY CROPS. ACHIEVEMENT OF THESE GOALS WILL DELIVER VARIETIES THAT CAN BE GROWN IN A PRODUCTION SYSTEM THAT MAXIMIZES YIELD, STORAGE ROOT QUALITY AND CULINARY ATTRIBUTES, THUS ENABLING STAKEHOLDERS ALONG THE US SWEETPOTATO SUPPLY CHAIN TO MAINTAIN THEIR COMPETITIVE ADVANTAGE IN THE US AND GLOBAL MARKETPLACE.

SMART TEXTILES AND WEARABLES: COMMUNITY INVESTMENT PROJECT (NO IDC)

PIRE: U.S.-EAST AFRICA RESEARCH AND EDUCATION PARTNERSHIP: CASSAVA MOSAIC DISEASE - A PARADIGM FOR THE EVOLUTION OF INSECT-TRANSMITTED PLANT VIRUS PA

RYAN WHITE TITLE III: EARLY INTERVENTION SERVICES

BUILDING CAPACITY TO CONTROL VIRAL FOODBORNE DISEASE: A TRANSLATIONAL, MULTIDISCIPLINARY APPROACH

BUILDING CAPACITY TO CONTROL VIRAL FOODBORNE DISEASE: A TRANSLATIONAL, MULTIDISCIPLINARY APPROACH

BUILDING CAPACITY TO CONTROL VIRAL FOODBORNE DISEASE: A TRANSLATIONAL, MULTIDISCIPLINARY APPROACH

BUILDING CAPACITY TO CONTROL VIRAL FOODBORNE DISEASE: A TRANSLATIONAL, MULTIDISCIPLINARY APPROACH

TITLE: BUILDING PANDEMIC RESILIENCE IN NATIVE AMERICAN COMMUNITIES PURPOSE: THE PURPOSE OF THIS GRANT IS TO TEST A MOBILE, EFFICIENT, AND RAPIDLY DEPLOYABLE RENEWABLE-ENERGY BASED ELECTRIFICATION RESPONSE IN NATIVE AMERICAN COMMUNITIES TO BUILD PANDEMIC RESILIENCE THROUGH POWER GRID INFRASTRUCTURE.ACTIVITIES TO BE PERFORMED: THE PROJECT TEAM WILL DEVELOP A MODULAR, SELF-CONTAINED, SOLAR-POWERED, ENERGY STORAGE SYSTEM BACKED MICROGRID THAT CAN BE DEPLOYED IN ENVIRONMENTS WITH INSUFFICIENT POWER GRIDS. THE TEAM WILL DEVELOP A NOVEL SILICON-CARBIDE (SIC) AND GALLIUM-NITRIDE (GAN) FAST-CHARGING NANOGRID-TIED SYSTEM OF UNMANNED AERIAL VEHICLES AND A COMPACT, SOLAR-POWERED, AND ENERGY STORAGE INTERFACED 4 KW POWER SYSTEMS. THE TEAM WILL ALSO DEVELOP A COMPACT, LOW-COST, AND ENERGY-EFFICIENT GAN/SIC-BASED AIR-QUALITY CONTROL SYSTEM WITH PATHOGEN SENSING AND DISINFECTION CAPABILITIES.EXPECTED OUTCOMES: THIS PROJECT WILL DEVELOP RELIABLE, AFFORDABLE, QUALITY ENERGY SOURCES THAT CAN SUPPORT MOBILE HEALTH CARE UNITS, EXPANDED ECONOMIC OPPORTUNITY AND COMMUNITY DEVELOPMENT IN NATIVE COMMUNITIES, AND NEW EDUCATION AND WORKFORCE OPPORTUNITIES.INTENDED BENEFICIARIES: NATIVE AMERICAN COMMUNITIES IN RURAL AREAS WILL BENEFIT FROM DELIVERY OF CRITICAL MEDICAL SUPPLIES; HOME POWER SYSTEMS THAT CAN SUPPORT REFRIGERATION, LIGHTING, AND CRITICAL MEDICAL EQUIPMENT USING RENEWABLE ENERGY; AND AIR QUALITY SENSORS, AND AIR-QUALITY CONTROL AND MITIGATION SYSTEM TO REDUCE AIRBORNE INFECTION RISKS.SUBRECIPIENT ACTIVITIES: THE RECIPIENT PLANS TO SUBAWARD FUNDS TO CONDUCT RESEARCH INTO THE FOLLOWING THRUSTS: MODULAR CONTAINER-BASE MOBILE MICROGRID AND COMMUNITY POWER SYSTEM, SCALABLE HOME POWER SYSTEMS, AND COMBATING INDOOR RESPIRATORY INFECTION USING FLEXIBLE AIR-QUALITY CONTROL SYSTEMS.

CONSERVATION TILLAGE IN COMBINATION WITH COVER CROPS (CC) PLAYS AN IMPORTANT ROLE IN PRESERVING LONG-TERM WATER AND FOOD SECURITY. HOWEVER, ADOPTION OF THESE MANAGEMENT APPROACHES STILL REMAINS LOW. WE WILL DEVELOP A NETWORK OF EARLY CC AND CT ADOPTERS TO ADDRESS GAPS BETWEEN PERCEPTION AND REALITY OF HOW THESE TOOLS INFLUENCE WATER DYNAMICS. WE WILL MEASURE CC IMPACTS ON SOIL WATER ON MULTIPLE FARMS IN THE MID-ATLANTIC AND SOUTHEAST TO USE IN MODELING EFFORTS AIMED AT PRODUCERS, STAKEHOLDERS AND POLICY EDUCATORS. OBJECTIVES INCLUDE 1) QUANTIFY HOW ON-FARM MANAGEMENT INFLUENCES CC BIOMASS QUANTITY/QUALITY AND SUBSEQUENT EFFECTS ON WATER DYNAMICS ACROSS THE MID-ATLANTIC AND SOUTHEAST US; 2) MODEL SOIL WATER AND CC DECOMPOSITION TO DETERMINE WATER AVAILABILITY FOR FOLLOWING CASH CROP AND VOLUME OF WATER MOVING OUT OF THE PROFILE; 3) QUANTIFY AND SIMULATE HOW SOIL AND CC MANAGEMENT UNDER CURRENT AND FUTURE CLIMATES INFLUENCE CORN AND SOYBEAN YIELD (POTENTIAL, STABILITY AND ECONOMICS) IN THE MID-ATLANTIC AND SOUTHEAST; 4) DEVELOP AN OUTREACH PROGRAM, INFORMED BY OUR EARLY ADOPTER NETWORK OF FARMERS THAT IDENTIFIES AND OVERCOMES MISCONCEPTIONS ABOUT THE COST AND VALUE OF CCS; AND 5) PROVIDE SCIENCE-BASED DATA SUPPORTING INTEGRATION OF CCS INTO FEDERAL CROP INSURANCE PROGRAMS AND INCREASED FARMER ADOPTION OF ADVANCED RISK MANAGEMENT TOOLS (CT AND CCS). OUR TRANSDISCIPLINARY PROJECT ADDRESSES PROGRAM PRIORITIES OF "USE OF TRANSFORMATIVE DISCOVERIES TO REDUCE WATER USE", "INNOVATIVE WAYS TO SUSTAINABLY SECURE AND EFFICIENTLY USE WATER TO PRODUCE FOOD", AND "TARGETED ACTIVITIES TO OVERCOME BARRIERS/DISINCENTIVES SO THAT MORE SUSTAINABLE MANAGEMENT PRACTICES ARE ADOPTED".

APOLIPOPROTEIN GENES AND ATHEROGENESIS IN ANIMALS

NUCLEAR STRUCTURE RESEARCH AT THE TRIANGLE UNIVERSITIES NUCLEAR LABORATORY.

BUILDING CAPACITY TO CONTROL VIRAL FOODBORNE DISEASE: A TRANSLATIONAL, MULTIDISCIPLINARY APPROACH

NORTH CAROLINA STATE UNIVERSITY NEW OPEN 2021 AWARD CONTROL NUMBER: 2459-2977 TITLE: MICROGRID CONTROL/COORDINATION CO-DESIGN (MICROC3) MICROGRIDS (MG) DELIVER HIGHLY RESILIENT POWER SUPPLY TO LOCAL LOADS IN THE EVENT OF A POWER OUTAGE, WHILE IMPROVING DISTRIBUTION SYSTEM RELIABILITY BY REDUCING THE LOAD ON THE SYSTEM UNDER STRESS CONDITIONS. MICROGRIDS ARE ALSO WIDELY CONSIDERED AS AN ESSENTIAL TECHNOLOGY TO ADDRESS THE CHALLENGES OF CLIMATE CHANGE, BY INTEGRATING AND EFFECTIVELY MANAGING RENEWABLE GENERATION ON THE DISTRIBUTION SYSTEM, WHILE ALSO PROVIDING POWER TO CRITICAL LOADS DURING AND AFTER EXTREME WEATHER EVENTS WHEN THE REST OF THE GRID MAY BE DAMAGED.

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS

DEVELOPMENT AND APPLICATION OF NEW IONIZATION METHODS FOR BIOLOGICAL MASS SPECTRO

NEUTRINOS AND NUCLEOSYNTHESIS: SUPERNOVAE, GAMMA RAY BURSTS, AND LOW ENERGY BETA BEAMS

HISTORICALLY BLACK COLLEGES AND UNIVERSITIES PROGRAM

MONITORING AND EVALUATION ACTIVITIES FOR MALARIA CONTROL IN ETHIOPIA

SMITH LEVER 3B&C FUNDS

GRADUATE TRAINING IN BIOINFORMATICS

THE MISSION OF THE SOUTHERN IPM CENTER (SIPMC) IS TO FOSTER DEVELOPMENT AND ADOPTION OF INTEGRATED PEST MANAGEMENT (IPM), A SCIENCE-BASED APPROACH TO MANAGING PESTS IN WAYS THAT GENERATE ECONOMIC, ENVIRONMENTAL AND HUMAN HEALTH BENEFITS. SIPMC&#39;S UNIQUE STRENGTHS WILL BE LEVERAGED THROUGH COLLABORATION AMONG THREE SOUTHERN INSTITUTIONS (NORTH CAROLINA STATE UNIVERSITY, UNIVERSITY OF GEORGIA, AND AUBURN UNIVERSITY) IN PARTNERSHIP WITH REGIONAL STAKEHOLDERS IN MULTIPLE SECTORS FROM AGRICULTURAL, URBAN, AND RURAL SETTINGS TO IDENTIFY AND ADDRESS REGIONAL PRIORITIES FOR RESEARCH, EDUCATION, AND OUTREACH. ADDITIONAL SUPPORT AND DIRECTION HAS BEEN PROVIDED SO THAT SIPMC ALSO MANAGES A RICH PORTFOLIO OF APPLICATIONS AND EXPERTISE THAT SERVE AS THE FOUNDATION FOR THE IPM INFORMATION SUPPLEMENT. INCLUDED IN OUR CURRENT PROPOSAL ARE PROGRAMS THAT NOT ONLY SATISFY MULTIPLE PRIORITIES OF THE CROP PROTECTION AND PEST MANAGEMENT PROGRAM, BUT ALSO PROMOTE THE FIVE GOALS OF THE NATIONAL IPM ROADMAP. THESE INCLUDE 1) IMPROVED IPM PRACTICES THROUGH THE FOLLOWING PROGRAMS: REGULATORY SCIENCE NETWORK, FACILITATION OF INNOVATION THROUGH TECHNOLOGY (FITT), POLLINATOR PROTECTION, RESISTANCE MANAGEMENT, NATIONAL IPM DATABASE, AND GRANT PROGRAMS 2) ECONOMICAL IPM PRACTICES THROUGH FITT, INVASIVE SPECIES, RESISTANCE MANAGEMENT, NATIONAL IPM DATABASE, GRANT PROGRAMS, AND UNDERSERVED AUDIENCES 3) REDUCED ENVIRONMENTAL RISKS THROUGH FITT, INVASIVE SPECIES, GRANT PROGRAMS, RESISTANCE MANAGEMENT, AND UNDERSERVED AUDIENCES. 4) INCREASED IPM ADOPTION: FITT, INVASIVE SPECIES, REGULATORY SCIENCE NETWORK, GRANT PROGRAMS, EVALUATION AND COMMUNICATION, NATIONAL IPM DATABASE, FRIENDS OF SOUTHERN IPM AWARDS, AND UNDERSERVED AUDIENCES, AND FINALLY, 5) REDUCED HUMAN HEALTH RISKS THROUGH FITT, REGULATORY SCIENCE NETWORK, POLLINATOR PROTECTION, GRANT PROGRAMS, AND UNDERSERVED AUDIENCES.

SCHOOL LEADERSHIP PROGRAM

OPTIMIZING ORAL PEDIATRIC HIV VACCINES TO PREVENT BREAST MILK TRANSMISSION

HIV TROPISM, PERSISTENCE, INFLAMMATION AND NEUROCOGNITION IN THERAPY INITIATION

RISK OF INFLUENZA INFECTION IN A VACCINATED OBESE POPULATION

NORTH CAROLINA SPACE GRANT (NCSG) IS A STATE-WIDE NETWORK THAT EXTENDS GEOGRAPHICALLY ACROSS THE STATE OF NORTH CAROLINA FROM THE COAST TO THE MOUNTAINS.

METABOLIC IMPACTS OF PFAS EXPOSURE IN THE CAPE FEAR BASIN: GENX EXPOSURE STUDY - PROJECT SUMMARY/ABSTRACT – (BIOMEDICAL RESEARCH) PROJECT 1 PER- AND POLYFLUOROALKYL SUBSTANCES (PFAS) ARE COMMON DRINKING WATER CONTAMINANTS IN NORTH CAROLINA AND AROUND THE UNITED STATES. THESE CHEMICALS HAVE BEEN DETECTED IN THE DRINKING WATER OF COMMUNITIES LIVING ALONG THE CAPE FEAR RIVER IN NC. WORKING WITH COMMUNITY GROUPS ALONG THE CAPE FEAR RIVER, WE WILL EVALUATE PFAS EXPOSURE AND METABOLIC HEALTH EFFECTS (DYSLIPIDEMIA AND OBESITY) IN PEOPLE FROM THREE COMMUNITIES WHOSE DRINKING WATER HAS BEEN CONTAMINATED WITH PFAS. DISRUPTION OF LIPID HOMEOSTASIS AND IMPACTS ON WEIGHT GAIN HAVE BEEN ASSOCIATED WITH PFAS IN OTHER POPULATIONS. THE THREE COMMUNITIES HAVE EXPOSURE TO DIFFERENT PFAS. TWO OF THE COMMUNITIES (TOWN OF PITTSBORO AND LOWER CAPE FEAR AREA -- NEW HANOVER AND BRUNSWICK COUNTIES, NC) RELY ON THE CAPE FEAR RIVER FOR DRINKING WATER, WHILE A THIRD (THE PRIVATE WELL COMMUNITY SOUTH OF FAYETTEVILLE, NC) RELIES ON PRIVATE WELLS. PITTSBORO, LOCATED ON THE HAW RIVER IN THE UPPER REGION OF THE CAPE FEAR RIVER, IS EXPOSED TO HISTORICALLY USED PFAS. THE FAYETTEVILLE PRIVATE WELL COMMUNITY IS LOCATED NEAR A PFAS MANUFACTURING PLANT WHICH HAS DISCHARGED NOVEL PFAS TO BOTH AIR AND WATER (CAPE FEAR RIVER) SINCE 1980; THEIR WELLS ARE CONTAMINATED FROM PFAS AIR TRANSPORT. NEW HANOVER AND BRUNSWICK COUNTIES, AT THE MOUTH OF THE CAPE FEAR RIVER AND DOWNSTREAM OF THE CHEMICAL PLANT, ARE EXPOSED TO BOTH HISTORICALLY USED PFAS (E.G., PFOA, PFOS) AS WELL AS NOVEL PFAS (E.G., GENX, NAFION BYPRODUCT 2). SOME OF THESE NOVEL PFAS WERE FOUND IN HIGH LEVELS IN DRINKING WATER, BUT NOT DETECTABLE IN HUMAN SERUM (E.G., GENX, PFMOAA); EXPOSURE RECONSTRUCTION IS NECESSARY TO ESTIMATE HEALTH EFFECTS FROM PAST EXPOSURES. WE RECRUITED ~1000 INDIVIDUALS AGES 6 AND OLDER (200 FROM PITTSBORO, 300 FROM FAYETTEVILLE PRIVATE WELL COMMUNITY, AND 500 FROM WILMINGTON) INTO THE GENX STUDY COHORT IN 2020-21 TO FOLLOW OVER TIME TO EVALUATE HOW PFAS CHEMICALS INFLUENCE HUMAN HEALTH. FOR THIS CURRENT EFFORT, WE WILL FOCUS PROSPECTIVELY ON HOW PFAS INFLUENCE DYSLIPIDEMIA AND OBESITY. WE WILL UPDATE THE HEALTH HISTORY OF THIS COHORT ANNUALLY. IN YEARS 2 & 3 WE WILL COLLECT NEW BLOOD SAMPLES FOR LIPID AND PFAS ANALYSIS AND MEASURE BODY COMPOSITION USING BIOIMPEDANCE. WE WILL LINK PREVIOUSLY COLLECTED INFORMATION ON RESIDENTIAL HISTORY TO ESTIMATES OF HISTORIC LEVELS OF THE NEW PFAS TO CREATE ESTIMATES FOR HEALTH EFFECTS ANALYSIS. BECAUSE MOST INDIVIDUALS HAVE MEASURABLE EXPOSURE TO MORE THAN 8 DIFFERENT PFAS AND BECAUSE THE EFFECTS OF PFAS ON LIPIDS AND WEIGHT CAN BE NON-LINEAR, WE WILL DEVELOP NEW STATISTICAL METHODOLOGY TO EVALUATE BOTH THE EFFECTS OF INDIVIDUAL PFAS AND ALL PFAS TOGETHER. WE WILL REPORT BACK INDIVIDUAL AND COMMUNITY LEVEL RESULTS ON A REGULAR BASIS AND WILL CONDUCT COMMUNITY-INITIATED ANALYSES. WE HAVE A COMMUNITY SCIENCE ADVISORY PANEL TO PROVIDE INPUT TO THE STUDY AND ENSURE THAT THE STUDY INVESTIGATORS ARE WELL INFORMED ABOUT COMMUNITY CONCERNS. THIS STUDY WITH ITS COMPLEX MIX OF PFAS AND GEOGRAPHICALLY DIVERSE SAMPLE WILL PROVIDE KEY INSIGHTS TO THE HUMAN HEALTH IMPLICATIONS OF PFAS BOTH IN NC AND AROUND THE WORLD.

AN INTEGRATED APPROACH TO THE BULK III-NITRIDE CRYSTAL GROWTH AND WAFERING

TAS::89 0321::TAS DEVELOPMENT OF METHODOLOGIES FOR DETERMINING PREFERRED LANDSCAPE DESIGNS FOR SUSTAINABLE BIOENERGY FEEDSTOCK PRODUCTION SYSTEMS

PURPOSE: THE NATIONAL SEA GRANT COLLEGE PROGRAM WAS ESTABLISHED BY THE U.S. CONGRESS IN 1966 (AMENDED IN 2008, PUBLIC LAW 110-394) TO BE A HIGHLY LEVERAGED FEDERAL AND STATE PARTNERSHIP TO HARNESS THE INTELLECTUAL CAPACITY OF THE NATION'S UNIVERSITIES AND RESEARCH INSTITUTIONS TO SOLVE PROBLEMS AND GENERATE OPPORTUNITIES IN COASTAL COMMUNITIES. FOR OVER 50 YEARS, THE NATIONAL SEA GRANT COLLEGE PROGRAM HAS SUPPORTED COASTAL AND GREAT LAKES COMMUNITIES THROUGH RESEARCH, EXTENSION AND EDUCATION. SEA GRANT'S MISSION IS TO ENHANCE THE PRACTICAL USE AND CONSERVATION OF COASTAL, MARINE AND GREAT LAKES RESOURCES IN ORDER TO CREATE A SUSTAINABLE ECONOMY AND ENVIRONMENT. THIS GRANT IS THE VEHICLE THROUGH WHICH NORTH CAROLINA SEA GRANT LAYS OUT ITS PLAN TO IMPLEMENT THE GOALS LAID OUT IN IN THEIR FY2018-23 STRATEGIC PLAN, WHICH CAN BE FOUND AT: HTTPS://SEAGRANT.NOAA.GOV/INSIDESEAGRANT/PLANNING IN ADDITION TO REQUIRED GRANT PROGRESS REPORTING, THE RECIPIENT WILL REPORT DEFINED MEASURES AND METR

SOCIAL ADVERSITIES, EPIGENETICS, AND THE OBESITY EPIDEMIC

FORWARD VIEWING CATHETER-DELIVERED MICROBUBBLE ENHANCED SONOTHROMBOLYSIS (FV-CAMUS)

THE HATCH ACT OF 1887 (REGULAR RESEARCH)

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING (BHWET) PROGRAM

TO APPLY CUTTING EDGE TECHNOLOGY IN ADVANCED DIAGNOSIS OF PLANT QUARANTINE AND/OR SELECT AGENT PATHOGENS, AND TO VALIDATE NOVEL TECHNOLOGIES AND PLA

NORTH CAROLINA SBDC

NORTH CAROLINA SBDC

NORTH CAROLINA SBDC

REAL-TIME FARMER LEARNING ON BENEFITS OF COVER CROPS FOR MANGING SOIL HEALTH, AND WATER AND NUTRIENTS DYNAMICS

GENETIC ETIOLOGY OF CANCER DRUG RESPONSE

TRAINING IN BIOCHEMICAL AND ENVIRONMENTAL TOXICOLOGY

MULTISCALE MODELING OF WOUND HEALING

RAF/MEK/ERK REGULATION OF AXON GROWTH AND DIFFERENTIATION

INTEGRATED BIOSTATISTICAL TRAINING FOR CVD RESEARCH

NORTH CAROLINA SBDC

CANCER TRAINING GRANT

GENETIC EPIDEMIOLOGY OF CAUSAL VARIANTS ACROSS THE LIFE COURSE PHASE II (CALICO I

TRAINING PROGRAM IN MATERNAL AND CHILD HEALTH

NORTH CAROLINA SBDC

ULTRA-LOW COST, ALL-SILICON CARBIDE MODULAR POWER CONVERTERS FOR DIRECT CURRENT FAST CHARGING EQUIPMENT CONNECTED DIRECTLY TO MEDIUM VOLTAGE DISTRIBUTION SYSTEM DE-EE0009871 NORTH CAROLINA STATE UNIVERSITY

SMITH LEVER 3B&C FUNDS

MULTI-SCALE MODELING AND PHYLODYNAMICS FOR HEALTHCARE ASSOCIATED INFECTIONS

THE ELONGATION HYPOTHESIS OF AUTISM

VAGINAL/RECTAL HIV TRANSMISSION MODEL

SMALL BUSINESS DEVELOPMENT CENTERS

REGULATION AND MODELING OF LIGNIN BIOSYNTHESIS

THE BROWN MARMORATED STINK BUG (BMSB) IS AN INVASIVE INSECT THAT FIRST APPEARED AS A SEVERE ECONOMIC PEST OF SPECIALTY CROPS IN THE MID-ATLANTIC IN 2010. IT HAS SINCE SPREAD TO 43 STATES AND IS NOW A THREAT TO SPECIALTY CROPS ACROSS MUCH OF THE US. A SCRI CAP (2011-2016) DEVELOPED CHEMICAL CONTROL STRATEGIES AND FUNDAMENTAL BIOLOGICAL AND ECOLOGICAL INFORMATION ON BMSB. WHILE THE CHEMICAL CONTROL COMPONENT PROVIDED SHORT-TERM RELIEF FOR PRODUCERS, RELIANCE ON BROAD SPECTRUM INSECTICIDES HAVE NEGATIVELY AFFECTED NON-TARGET ORGANISMS AND LED TO SECONDARY PEST OUTBREAKS. THIS PROJECT BUILDS UPON PREVIOUS FINDINGS, BUT RE-FOCUSES EFFORTS ON STAKEHOLDER-DRIVEN OBJECTIVES FOR LONG-TERM, SUSTAINABLE MANAGEMENT. THE PROJECT ADDRESSES SCRI GOALS ASSOCIATED WITH ASSRESSING THREASTS FROM PESTS, AND EFFORTS TO IMPROVE PRODUCTION EFFICIENCY. WE WILL IMPROVE OUR KNOWLEDGE OF BMSB RISK TO CROPS THROUGH ENHANCED UNDERSTANDING OF AGROECOLOGY AND LANDSCAPE ECOLOGY, IMPLEMENT WIDESPREAD BIOLOGICAL CONTROL OF BMSB WITH AN EXOTIC ASIAN PARASITOID AND NATIVE NATURAL ENEMIES, AND DEVELOP MANAGEMENT TOOLS AND STRATEGIES COMPATIBLE WITH BIOLOGICAL CONTROL AND INFORMED BY RISK FROM LANDSCAPE FACTORS. WE WILL CONTINUE TO DETERMINE THE ECONOMIC CONSEQUENCES OF BMSB DAMAGE AND HOW IT IS REDUCED BY SPECIFIC MANAGEMENT STRATEGIES, AND DELIVER SCIENCE-BASED INFORMATION WITH A ROBUST AND DIVERSIFIED OUTREACH PROGRAM BASED ON THE INFRASTRUCTURE DEVELOPED DURING THE FIRST SCRI PROJECT. THE NEW PROJECT IS NATIONAL IN SCOPE TO ADDRESS THE IMMINENT THREAT OF BMSB TO SPECIALTY CROPS IN REGIONS INVADED SINCE 2010 (SOUTHEAST, GREAT LAKES, PACIFIC NORTHWEST AND WEST), WHICH HAVE UNIQUE STAKEHOLDERS, CROPPING SYSTEMS AND LANDSCAPES.

SMALL BUSINESS DEVELOPMENT CENTERS

ASSISTING STROKE SURVIVORS WITH ENGINEERING TECHNOLOGY ? ASSET - SENSORIMOTOR IMPAIRMENTS TYPICALLY PERSIST AFTER STROKE, DESPITE EXTENSIVE CLINICAL AND RESEARCH REHABILITATION EFFORTS TO PROMOTE RECOVERY THROUGH THERAPY. THESE IMPAIRMENTS CONTRIBUTE TO PERFORMANCE DEFICITS IN A VARIETY OF DAILY ACTIVITIES, NEGATIVELY AFFECTING SOCIAL INTERACTIONS, ECONOMIC OPPORTUNITIES, AND SELF-CARE. THUS, STROKE REMAINS THE LEADING CAUSE OF MAJOR, LONG-TERM DISABILITY IN ADULTS IN THE U.S. IN LIGHT OF THIS SITUATION, EXPLORATION OF ALTERNATIVE MEANS TO RESTORE FUNCTION SEEM WARRANTED. WITH RECENT TECHNOLOGICAL ADVANCES, THE POTENTIAL FOR WEARABLE ASSISTIVE DEVICES TO MITIGATE THE EFFECTS OF THESE PERFORMANCE DEFICITS HAS GROWN CONSIDERABLY. THESE ASSISTIVE DEVICES (INTENDED TO MAKE AN IMMEDIATE CHANGE IN FUNCTION WITHOUT NECESSARILY MODIFYING THE UNDERLYING IMPAIRMENT) HAVE THE POWER TO ALLOW USERS TO REGAIN CONTROL OF MOVEMENT OF THEIR ARMS AND LEGS AND TO SENSE THOSE MOTIONS EVEN WHEN THE NEURAL DAMAGE REMAINS. YET, CURRENT USE OF ASSISTIVE DEVICES TO ADDRESS FUNCTIONAL LOSS IS QUITE LIMITED, BEYOND THE PASSIVE CANES AND ORTHOSES THAT HAVE BEEN USED FOR DECADES. REHABILITATION EFFORTS FOR PEOPLE WITH CHRONIC SENSORIMOTOR DEFICITS AFTER STROKE CONTINUE TO FOCUS ON THERAPY RATHER THAN ASSISTANCE, PARTIALLY DRIVEN BY A HISTORY OF POOR ADOPTION OF TECHNOLOGY. THE PROPOSED REHABILITATION ENGINEERING RESEARCH CENTER (RERC), ASSISTING STROKE SURVIVORS WITH ENGINEERING TECHNOLOGY (ASSET), WILL EXPLICITLY ADDRESS KEY CHALLENGES SLOWING UPTAKE OF ASSISTIVE DEVICES BY STROKE SURVIVORS. IN COMPARISON WITH THERAPEUTIC TECHNOLOGY, SUCCESSFUL ADOPTION OF ASSISTIVE DEVICES PRESENTS A UNIQUE SET OF ISSUES THAT WARRANT INDEPENDENT EXAMINATION. IN ADDITION TO COMMON CONCERNS FOR WEARABLE DEVICES SUCH AS MASS AND POWER SOURCES, THE REQUIREMENTS FOR ASSISTIVE DEVICES SHOULD INCLUDE FOSTERING A SYNERGISTIC CONNECTION BETWEEN THE USER AND THE DEVICE. THE SIX PROJECTS SUPPORTED BY THE ASSET CENTER WILL FOCUS ON DIFFERENT ASPECTS OF HUMAN-MACHI NE SYNERGY: 1) TRAINING THE USER TO OPTIMIZE DEVICE ASSISTANCE; 2) DESIGNING THE DEVICE TO ADAPT TO DIFFERENT ENVIRONMENTS; 2) PROVIDING THE USER WITH AUGMENTED SENSORY FEEDBACK OF TASK PERFORMANCE; 4) FACILITATING MECHANICAL COUPLING AND COMMUNICATION BETWEEN THE USER AND DEVICE; 5) IMPROVING WALKING BALANCE THROUGH REAL-TIME USER MONITORING; AND 6) ENHANCING CONTROL OF DISTAL LIMB ORIENTATION FOR IMPROVED TASK PERFORMANCE. STROKE SURVIVORS AND THEIR CAREGIVERS WILL PARTICIPATE THROUGHOUT THE PROCESS TO PROVIDE FEEDBACK AND INSIGHT. THE SUCCESSFUL ADOPTION OF TECHNOLOGY IS HIGHLY DEPENDENT ON EDUCATION, DISSEMINATION AND TRAINING EFFORTS. THE CENTER WILL STRIVE TO INVOLVED ALL STAKEHOLDERS IN THESE ENDEAVORS, INCLUDING STROKE SURVIVORS, CAREGIVERS, CARE PROVIDERS, AND RESEARCHERS. WHILE THE EFFORTS OF THE ASSET RERC WILL ADDRESS TECHNOLOGY FOR SPECIFIC LIMBS AND JOINTS, THE CENTER OUTCOMES WILL HAVE RELEVANCE FOR OTHER DEVICES AND BODY SEGMENTS, THEREBY WIDELY IMPACTING THE FIELD OF ASSISTIVE TECHNOLOGY THAT ENHANCES FUNCTIONAL TASK PERFORMANCE FOR PEOPLE WITH STROKE.

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH SUPPORTING BTO IN THE AMOUNT OF 1,465,513 ON CONTRACT HR0011-17-2-0046.

GENETICS OF ALCOHOL SENSITIVITY IN DROSOPHILA

DEFINING REMISSION AND RECOVERY IN EATING DISORDERS

MURI ENABLING EXTREME BANDGAP ELECTRONICS EXBE

ADD HEALTH: A GENOTYPE AND PHENOTYPE RESOURCE FOR THE GLOBAL SCIENTIFIC COMMUNITY

THE GOAL OFTHE NASA/INDUSTRY INTERNSHIP/FELLOWSHIP/SCHOLARSHIP PROGRAM IS TO PROVIDE RESEARCH AND EDUCATION OPPORTUNITIES TO STUDENTS IN STEM DEGREE

SMALL BUSINESS DEVELOPMENT CENTERS

SOCIAL COGNITION AND AGING

SEX- AND AGE-DEPENDENT ACL FUNCTION IN THE GROWING KNEE JOINT

NC STATE BTEC RESPONSE TO FOA EP-IDS-10-002 FOR INTERMEDIATE AND ADVANCED BIOMANUFACTURING TRAINING

TURBULENT MHD FLOW MODELING IN ANNULAR LINEAR INDUCTION PUMPS WITH VALIDATION EXPERIENTS

MOLECULAR GENETICS OF OLFACTION IN DROSOPHILIA

SYNTHETIC PLATELETLIKE PARTICLES TO ADDRESS POST-TRAUMATIC BRAIN INJURY COAGULOPATHY AND NEUROINFLAMMATORY PATHOLOGY

THE LEONARDO PROJECT: AN INTELLIGENT CYBERLEARNING SYSTEM FOR INTERACTIVE SCIENTIFIC MODELING IN ELEMENTARY SCIENCE EDUCATION