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DIRECT BIOELECTRONIC DETECTION OF SARS-COV-2 FROM SALIVA USING SINGLE-MOLECULE FIELD-EFFECT TRANSISTOR ARRAY - DIRECT BIOELECTRONIC DETECTION OF SARS-COV-2 FROM SALIVA USING SINGLE-MOLECULE FIELD-EFFECT TRANSISTOR ARRAY NUCLEIC ACID TESTS HAVE BECOME THE GOLD-STANDARD FOR DIAGNOSTIC TESTING FOR COVID-19, USUALLY PERFORMED IN SPECIALIZED LABORATORIES. MOST ARE BASED ON REVERSE-TRANSCRIPTION QUANTITATIVE POLYMERASE CHAIN REACTION (QRT-PCR). THE TIME REQUIRED FOR SPECIMEN TRANSPORT AND PROCESSING RESULTS IN A TURNAROUND TIME THAT IS TYPI- CALLY SEVERAL DAYS. THE FEW RAPID (<1 HOUR) POINT-OF-CARE (POC) TESTS ARE MORE EXPENSIVE, STILL REQUIRE SAMPLE PREPARATION AND SPECIALIZED REAGENTS, AND DO NOT HAVE THE THROUGHPUT NEEDED FOR POPULATION SURVEILLANCE. DI- RECT TESTING FOR THE VIRUS, WHICH ALSO REDUCES REQUIREMENTS FOR MULTIPLE REAGENTS, IS A NECESSARY STEP TO IMPROV- ING DIAGNOSTIC TESTING. WHILE FOUR SUCH ANTIGEN TESTS HAVE BEEN APPROVED FOR DETECTION OF SARS-COV-2 BASED ON IMMUNOASSAYS TO THE N PROTEIN, SENSITIVITY IS LIMITED AND NO QUANTITATION OF VIRAL LOAD IS POSSIBLE. WE WILL ADDRESS THIS GAP BY USING DIAGNOSTIKOSTM, AN IN-DEVELOPMENT RAPID POC PLATFORM FOR DIRECT, REAL- TIME, MULTIPLEXED, QUANTITATIVE BIOELECTRONIC DETECTION OF BIOMOLECULES THAT EMPLOYS AN ALL-ELECTRONIC DETECTION DEVICE THAT FUNCTIONS AT THE SINGLE-MOLECULE LEVEL. THESE SINGLE-MOLECULE FIELD-EFFECT TRANSISTORS (SMFETS) ARE ARRAYED ON A COMPLEMENTARY METAL-OXIDE-SEMICONDUCTOR (CMOS) INTEGRATED CIRCUIT CHIP. CHIPS WILL INTERFACE WITH AN ENVISIONED USB-STICK-FORM-FACTOR READER DEVICE. ROBUST SINGLE-DOMAIN ANTIBODIES, KNOWN AS NANOBOD- IES AND IMMOBILIZED ON THESE DEVICES, ARE USED FOR SENSITIVE DETECTION OF VIRAL PARTICLES AND VIRAL DEBRIS. THE USE OF MULTIPLE NANOBODIES FOR A SINGLE PROTEIN AND NANOBODIES FOR DIFFERENT PROTEINS IN A SINGLE ASSAY ALLOWS FOR SIGNIFICANT IMPROVEMENTS IN SPECIFICITY. NANOBODIES WILL BE SPECIFIC FOR ONE OR MORE OF THE FOUR MAJOR STRUC- TURAL PROTEINS IN SARS-COV-2; THE NUCLEOCAPSID (N) PROTEIN ENGULFING THE VIRAL RNA, THE SPIKE (S) PROTEIN, THE MEMBRANE (M) PROTEIN AND THE ENVELOPE (E) PROTEIN. NO SAMPLE PREPARATION OR SPECIALIZED REAGENTS ARE RE- QUIRED FOR DETECTION, AND THE DEVICE WILL BE DESIGNED TO OPERATE WITH SALIVA, WHICH HAS VERY RECENTLY BEEN SHOWN TO BE A RELIABLE MEDIUM FOR DETECTING SARS-COV-2. INDIVIDUAL SENSOR CHIPS CAN BE MANUFACTURED AT A COST OF $35. WITH THE ADDITION OF OTHER NANOBODIES, THESE LARGE DENSE ARRAYS CAN ALSO ALLOW DETECTION OF MANY PATHOGENS IN A SINGLE TEST. IN THIS DIRECT-TO-PHASE-2 SBIR PROGRAM WE WILL PURSUE SEVERAL KEY INNOVATIONS THAT ARE REQUIRED TO MAKE SUCH A PLATFORM POSSIBLE, INCLUDING ISOLATION OF NANOBODIES FOR KEY STRUCTURE PROTEINS OF SARS-COV-2 (SPECIFIC AIM 1), DEVELOPMENT OF THE SMFET PLATFORM FOR ANTIGEN DETECTION (SPECIFIC AIM 2), DEVELOPMENT OF LARGE CMOS ARRAYS OF THESE SMFET DEVICES (SPECIFIC AIM 3), AND VERIFICATION OF DETECTION IN INCREASINGLY COMPLEX SAMPLES UP TO AND INCLUDING CLINICAL SAMPLES (SPECIFIC AIM 4). THIS PROJECT IS A PARTNERSHIP BETWEEN UNIVERSITY RESEARCHERS WHO DEVELOPED THE SMFET TECHNOLOGY AND A VENTURE-BASED START-UP VENTURE, QUICKSILVER BIOSCI- ENCES, SPUN OUT TO COMMERCIALIZE SMFET TECHNOLOGY AND DEVELOP SMFET/CMOS ARRAYS FOR MOLECULAR DIAG- NOSTIC APPLICATIONS.

DEVELOPMENT OF ULTRASOUND-FACILITATED FORMALIN-FIXED AND PARAFFIN-EMBEDDED TISSUE

PURPOSE: THE PURPOSE OF HUD’S COMPREHENSIVE HOUSING COUNSELING (CHC) GRANT IS TO PROVIDE DIRECT FUNDING SUPPORT TO HUD’S NATION-WIDE NETWORK OF APPROVED HOUSING COUNSELING AGENCIES. FOR MORE INFORMATION ABOUT THE COMPREHENSIVE HOUSING COUNSELING GRANT PROGRAM, SEE HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/HOUSING/SFH/HCC.; ACTIVITIES TO BE PERFORMED: HOUSING COUNSELING ACTIVITIES INCLUDE PROVIDING INFORMATION, ADVICE, AND TOOLS FOR CONSUMERS SEEKING, FINANCING, MAINTAINING, RENTING, OR OWNING A HOME. AGENCIES ALSO ASSIST THOSE FACING HOMELESSNESS AND HOMEOWNERS IN NEED OF FORECLOSURE ASSISTANCE. THE HOUSING COUNSELING ACTIVITY TYPES THAT CAN BE REIMBURSED BY THE CHC GRANT INCLUDE ALL APPROVED HOUSING COUNSELING, EDUCATION, AND OUTREACH TOPICS LISTED IN THE CURRENT. HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/ADMINISTRATION/HUDCLIPS/HANDBOOKS/HSGH/7610.1. THIS INCLUDES, BUT IS NOT LIMITED TO, PRE-PURCHASE/HOME BUYING COUNSELING, RESOLVING, OR PREVENTING FORWARD OR REVERSE MORTGAGE DELINQUENCY OR DEFAULT COUNSELING, AND NON-DELINQUENCY POST-PURCHASE COUNSELING. GRANTEES ARE REQUIRED TO DEMONSTRATE, THROUGH THE CURRENT FORM HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/ADMINISTRATION/HUDCLIPS/FORMS/HUD9, HOUSING COUNSELING AGENCY ACTIVITY REPORT, THE NUMBER OF HOUSEHOLDS THAT WERE COUNSELED BY ACTIVITY TYPE AND NUMBER OF HOUSEHOLDS THAT ATTENDED WORKSHOPS BY ACTIVITY TYPE DURING THE APPLICABLE FISCAL YEAR. HOUSING COUNSELING AGENCIES MAY ALSO BE SPECIFICALLY AWARDED TO PARTNER WITH A MINORITY-SERVING INSTITUTION (MSI) TO PROVIDE HOUSING COUNSELING TO THE MSI INSTITUTIONS’ COMMUNITIES AND EXPAND THESE INSTITUTIONS’ PARTNERSHIPS WITH HOUSING COUNSELING AGENCIES. OUTPUTS AND DELIVERABLES FOR THIS GRANT AWARD IS THE SAME AS THE PARAGRAPH DESCRIBED ABOVE, HOWEVER, GRANTEES ARE REQUIRED TO PARTNER WITH A MSI TO PROVIDE THOSE ACTIVITIES. ; EXPECTED OUTCOMES: THE QUANTIFIABLE OUTCOMES FOR THE CHC GRANT INCLUDE, BUT ARE NOT LIMITED TO, THE NUMBER OF HOUSEHOLDS THAT GAINED ACCESS TO HOUSING RESOURCES; RECEIVED INFORMATION ON FAIR HOUSING, FAIR LENDING, AND/OR ACCESSIBILITY RIGHTS; IMPROVED CURRENT LIVING CONDITIONS; PURCHASED HOUSING; RECEIVED A REVERSE MORTGAGE; PREVENTED OR RESOLVED A MORTGAGE DEFAULT; AND RECEIVED A LOAN MODIFICATION. ALL POSSIBLE OUTCOMES ARE LISTED IN SECTION 10 OF THE CURRENT FORM HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/ADMINISTRATION/HUDCLIPS/FORMS/HUD9, HOUSING COUNSELING AGENCY ACTIVITY REPORT.; INTENDED BENEFICIARIES: INDIVIDUALS, GROUPS OF INDIVIDUALS, AND FAMILIES WHO ARE RENTERS, TENANTS, HOMEOWNERS, AND HOME BUYERS UNDER HUD, CONVENTIONAL, AND OTHER GOVERNMENT PROGRAMS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

RAPID DEVELOPMENT OF A HIGHLY SPECIFIC DENGUE DIAGNOSTIC TEST

RAPID DEVELOPMENT OF A ZIKA-SPECIFIC DIAGNOSTIC TEST

SBIR PHASE I: REGENERABLE ANTIMICROBIAL PAINTS BASED ON HYDROGEN PEROXIDE

SBIR PHASE I: RAPID COVID-19 DIAGNOSTICS WITH CMOS-INTEGRATED SINGLE-MOLECULE FIELD-EFFECT TRANSISTORS

PORTABLE CHIP TRAILER TIPPER TO FACILITATE INTERSTATE TRANSPORTATION OF WOODY BIOMASS

SBIR PHASE I: SINGLE-MOLECULE FIELD-EFFECT TRANSISTOR ARRAYS FOR MULTIPLEXED GENOMIC IDENTIFICATION OF INFECTIOUS DISEASES

QUICKHYDRA NETWORK SECURITY SYSTEM

REAP IRA RES GRANT UNRESTRICTED (FY 25)

HOUSING COUNSELING ASSISTANCE PROGRAM

PURPOSE: THE PURPOSE OF HUD’S COMPREHENSIVE HOUSING COUNSELING (CHC) GRANT IS TO PROVIDE DIRECT FUNDING SUPPORT TO HUD’S NATION-WIDE NETWORK OF APPROVED HOUSING COUNSELING AGENCIES. FOR MORE INFORMATION ABOUT THE COMPREHENSIVE HOUSING COUNSELING GRANT PROGRAM, SEE HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/HOUSING/SFH/HCC.; ACTIVITIES TO BE PERFORMED: HOUSING COUNSELING ACTIVITIES INCLUDE PROVIDING INFORMATION, ADVICE, AND TOOLS FOR CONSUMERS SEEKING, FINANCING, MAINTAINING, RENTING, OR OWNING A HOME. AGENCIES ALSO ASSIST THOSE FACING HOMELESSNESS AND HOMEOWNERS IN NEED OF FORECLOSURE ASSISTANCE. THE HOUSING COUNSELING ACTIVITY TYPES THAT CAN BE REIMBURSED BY THE CHC GRANT INCLUDE ALL APPROVED HOUSING COUNSELING, EDUCATION, AND OUTREACH TOPICS LISTED IN THE CURRENT. HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/ADMINISTRATION/HUDCLIPS/HANDBOOKS/HSGH/7610.1. THIS INCLUDES, BUT IS NOT LIMITED TO, PRE-PURCHASE/HOME BUYING COUNSELING, RESOLVING, OR PREVENTING FORWARD OR REVERSE MORTGAGE DELINQUENCY OR DEFAULT COUNSELING, AND NON-DELINQUENCY POST-PURCHASE COUNSELING. GRANTEES ARE REQUIRED TO DEMONSTRATE, THROUGH THE CURRENT FORM HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/ADMINISTRATION/HUDCLIPS/FORMS/HUD9, HOUSING COUNSELING AGENCY ACTIVITY REPORT, THE NUMBER OF HOUSEHOLDS THAT WERE COUNSELED BY ACTIVITY TYPE AND NUMBER OF HOUSEHOLDS THAT ATTENDED WORKSHOPS BY ACTIVITY TYPE DURING THE APPLICABLE FISCAL YEAR. HOUSING COUNSELING AGENCIES MAY ALSO BE SPECIFICALLY AWARDED TO PARTNER WITH A MINORITY-SERVING INSTITUTION (MSI) TO PROVIDE HOUSING COUNSELING TO THE MSI INSTITUTIONS’ COMMUNITIES AND EXPAND THESE INSTITUTIONS’ PARTNERSHIPS WITH HOUSING COUNSELING AGENCIES. OUTPUTS AND DELIVERABLES FOR THIS GRANT AWARD IS THE SAME AS THE PARAGRAPH DESCRIBED ABOVE, HOWEVER, GRANTEES ARE REQUIRED TO PARTNER WITH A MSI TO PROVIDE THOSE ACTIVITIES. ; EXPECTED OUTCOMES: THE QUANTIFIABLE OUTCOMES FOR THE CHC GRANT INCLUDE, BUT ARE NOT LIMITED TO, THE NUMBER OF HOUSEHOLDS THAT GAINED ACCESS TO HOUSING RESOURCES; RECEIVED INFORMATION ON FAIR HOUSING, FAIR LENDING, AND/OR ACCESSIBILITY RIGHTS; IMPROVED CURRENT LIVING CONDITIONS; PURCHASED HOUSING; RECEIVED A REVERSE MORTGAGE; PREVENTED OR RESOLVED A MORTGAGE DEFAULT; AND RECEIVED A LOAN MODIFICATION. ALL POSSIBLE OUTCOMES ARE LISTED IN SECTION 10 OF THE CURRENT FORM HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/ADMINISTRATION/HUDCLIPS/FORMS/HUD9, HOUSING COUNSELING AGENCY ACTIVITY REPORT.; INTENDED BENEFICIARIES: INDIVIDUALS, GROUPS OF INDIVIDUALS, AND FAMILIES WHO ARE RENTERS, TENANTS, HOMEOWNERS, AND HOME BUYERS UNDER HUD, CONVENTIONAL, AND OTHER GOVERNMENT PROGRAMS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

ANTIMICROBIAL ABSORBENT PAD FOR REDUCING BACTERIAL CONTAMINATION OF PACKAGED POULTRY

DEVELOPMENT OF A NON-DESTRUCTIVE MOLECULAR EXTRACTION PLATFORM FOR QUANTITATIVE P

SBIR PHASE I: REGENERABLE ANTIMICROBIAL COATINGS CONTAINING ZINC OXIDE BINDERS FOR HYDROGEN PEROXIDE CLEANING SOLUTIONS

HOUSING COUNSELING ASSISTANCE PROGRAM

HOUSING COUNSELING ASSISTANCE PROGRAM

HOUSING COUNSELING ASSISTANCE PROGRAM

HOUSING COUNSELING ASSISTANCE PROGRAM

RURAL HEALTH CLINIC VACCINE CONFIDENCE PROGRAM

HOUSING COUNSELING ASSISTANCE PROGRAM

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT

HOUSING COUNSELING

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT

INTERCITY BUS SECURITY GRANTS

SEC. 9007 REAP-RENEW ENERGY SYS GRANTS (MAN)

THIS GRANT SUPPORTS THE COSTS INCURRED TO IMPLEMENT MEASURES TO RESPOND TO THE NOVEL CORONAVIRUS 2019 (COVID-19), WHICH MAY INCLUDE WORKPLACE SAFETY, MARKET PIVOTS, RETROFITTING FACILITIES, TRANSPORTATION, WORKER HOUSING, AND MEDICAL EXPENSES. IT PROVIDES NEEDED RELIEF TO THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS FOR THEIR COSTS INCURRED BETWEEN JANUARY 27, 2020, THE DATE UPON WHICH THE PUBLIC HEALTH EMERGENCY WAS DECLARED BY THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICE (HHS) UNDER SECTION 319 OF THE PUBLIC HEALTH SERVICE ACT, AND DECEMBER 31, 2021. BENEFICIARIES INCLUDE THE EMPLOYEES OF THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS.

SEC. 9007 REAP-RENEW ENERGY SYS GRANTS (MAN)

SEC 9007 REAP-RENEW ENERGY EFFICIENCY IMPROVE GRANTS, $20,000 OR LESS (MAN)

HOUSING COUNSELING

THIS GRANT SUPPORTS THE COSTS INCURRED TO IMPLEMENT MEASURES TO RESPOND TO THE NOVEL CORONAVIRUS 2019 (COVID-19), WHICH MAY INCLUDE WORKPLACE SAFETY, MARKET PIVOTS, RETROFITTING FACILITIES, TRANSPORTATION, WORKER HOUSING, AND MEDICAL EXPENSES. IT PROVIDES NEEDED RELIEF TO THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS FOR THEIR COSTS INCURRED BETWEEN JANUARY 27, 2020, THE DATE UPON WHICH THE PUBLIC HEALTH EMERGENCY WAS DECLARED BY THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICE (HHS) UNDER SECTION 319 OF THE PUBLIC HEALTH SERVICE ACT, AND DECEMBER 31, 2021. BENEFICIARIES INCLUDE THE EMPLOYEES OF THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS.

SEC 9007 REAP-RENEW ENERGY EFFICIENCY IMPROVE GRANTS, $20,000 OR LESS (MAN)

SEC 9007 REAP-RENEW ENERGY EFFICIENCY IMPROVE GRANTS, $20,000 OR LESS (MAN)

SEC 9007 REAP-RENEW ENERGY SYSTEMS GRANTS, $20,000 OR LESS (MAN)

ENERGY EFFICIENCY GRANTS

SEC 9007 REAP-RENEW ENERGY EFFICIENCY IMPROVE GRANTS, $20,000 OR LESS (MAN)

SEC 9007 REAP-RENEW ENERGY EFFICIENCY IMPROVE GRANTS, $20,000 OR LESS (MAN)

SEC 9007 REAP-RENEW ENERGY EFFICIENCY IMPROVE GRANTS, $20,000 OR LESS (MAN)

COMMUNITY FACILITY GRANTS

ASSISTANCE TO FIREFIGHTERS GRANT

ASSISTANCE TO FIREFIGHTERS GRANT

ASSISTANCE TO FIREFIGHTERS GRANT

ASSISTANCE TO FIREFIGHTERS GRANT

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT