Idaho State University

PRESCHOOL DEVELOPMENT GRANTS BIRTH TO FIVE (PDG B-5) RENEWAL GRANT - IDAHO

IDAHO STATE UNIVERSITY EMERGENCY FINANCIAL AID GRANT UNDER CARES ACT

IDAHO STATE UNIVERSITY EMERGENCY FINANCIAL AID GRANTS UNDER CARES ACT

IDAHO PRESCHOOL DEVELOPMENT BIRTH THROUGH FIVE (PDG-B-5) - IDAHO’S PDG B-5 SYSTEMS-BUILDING GRANT WILL HELP IDAHO MOVE FROM A SET OF STRONG BUT FRAGMENTED EARLY CHILDHOOD INITIATIVES TO A COHERENT STATEWIDE EARLY CARE AND EDUCATION (ECE) SYSTEM THAT MAXIMIZES SEAMLESS ACCESS AND CHOICE FOR FAMILIES WITH CHILDREN FROM BIRTH THROUGH AGE FIVE. THE PROJECT WILL BE ADMINISTERED BY IDAHO STATE UNIVERSITY (ISU), DESIGNATED AS THE STATE ENTITY RESPONSIBLE FOR EXECUTING AND MANAGING THE AWARD, IN CLOSE PARTNERSHIP WITH STATE AGENCIES, HEAD START AND EARLY HEAD START GRANTEES, FOSTER/KINSHIP CARE SERVICES/SYSTEMS, LOCAL SCHOOL DISTRICTS, FAITH-BASED ORGANIZATIONS, TRIBAL GOVERNMENTS, BUSINESS LEADERS, AND COMMUNITY-BASED PARTNERS. IN ADDITION TO TRACKING AND EVALUATION EFFORTS, THE TWO PRIMARY COMPONENTS OF THE IDAHO BIRTH-THROUGH-FIVE SYSTEMS INTEGRATION PROJECT INCLUDE: 1) REVIEWING/UPDATING THE STATEWIDE ECE NEEDS ASSESSMENT AND STRATEGIC PLAN, AND 2) PROMOTING OUTCOME STRATEGIES TO ADVANCE PDG B-5 PROGRAM PRIORITIES AND CRITICAL ELEMENTS. IDAHO HAS IDENTIFIED FOUR CRITICAL STRATEGIES TO ENHANCE THIS SYSTEMS-BUILDING WORK INCLUDING: 1) IDAHO’S EARLY LEARNING COLLABORATIVE SYSTEM, 2) FAMILY AND COMMUNITY ENGAGEMENT, 3) EARLY CARE AND EDUCATION PROGRAM SUSTAINABILITY, AND 4) EARLY CARE AND EDUCATION QUALITY ENHANCEMENT. EMBEDDED IN THESE FOUR CRITICAL STRATEGIES ARE THE FOLLOWING PROJECTS THAT ENGAGE CROSS SECTOR IMPLEMENTATION THROUGH STRATEGIC PARTNERSHIPS: 1) READY! FOR KINDERGARTEN®, 2) STRONG FAMILIES/STRONG EDUCATORS, 3) CHILD CARE MANAGEMENT SYSTEM, 4) CHILD CARE ROUNDTABLES AND SEMINARS, 5) BUSINESS AND ECONOMIC LEADERSHIP ENGAGEMENT, 6) HIGHER EDUCATION SCHOLARSHIPS FOR ECE PROFESSIONALS, 7) SUPPORT FOR THE CHILD DEVELOPMENT ASSOCIATE CREDENTIAL, 8) EMERGING ECE LEADERS PROJECT, 9) POSITIVE BEHAVIORAL SUPPORTS, 10) DEVELOPMENTAL MONITORING OUTREACH, 11) ACCESS TO QUALITY ECE FURNITURE, EQUIPMENT, MATERIALS, AND SUPPLIES, AND 12) ENHANCEMENT OF OUTDOOR EARLY LEARNING ENVIRONMENTS.

IDAHO ACCELERATOR CENTER ADVANCED FUEL CYCLE RESEARCH

EMPWRING IDAHO’S YOUTH THROUGH GROW YOUR OWN EFFORTS AND CULTURALLY RELEVANT AND INCLUSIVE EVIDENCE BASED MENTAL HEALTH PRACTICES.

HIGH-INTENSITY PULSED RADIATION FACILITY FOR CHEMICAL/BIOLOGICAL DEFENSE:YEAR 3

INTERDISCIPLINARY SCHOLARSHIP FOR SERVICE FOR THE INTER-MOUNTAIN WEST - IDAHO STATE UNIVERSITY

REYNOLDS CREEK CARBON CRITICAL ZONE OBSERVATORY

COMMUNITY HEALTH WORKER TRAINING PROGRAM - ADDRESS: 1311 E CENTRAL DR, MERIDIAN, ID 83642 PROJECT DIRECTOR NAME: RYAN P. LINDSAY, PHD, MPH CONTACT PHONE NUMBERS: (V) 208-373-1779. (F) 208-282-4903 EMAIL ADDRESS: RYANLINDSAY@ISU.EDU WEB SITE ADDRESS: HTTPS://WWW.ISU.EDU/PUBLICHEALTH/CHW/ GRANT FUNDS REQUESTED: $2,994,236 OVERVIEW: THE PROPOSED PROJECT, ADVANCING COMMUNITY HEALTH WORKER TRAINING IN IDAHO, ADDRESSES HEALTH INEQUITIES IN RURAL AND UNDERSERVED IDAHO COMMUNITIES BY ESTABLISHING A COMMUNITY HEALTH WORKER (CHW) ACADEMY. THE CHW ACADEMY WILL MEET CHW, COMMUNITY-BASED, AND CLINIC-BASED IDENTIFIED TRAINING AND EMPLOYMENT NEEDS BY RECRUITING AND TRAINING NEW CHWS, PROVIDING ADVANCED AND EXPERIENTIAL TRAINING TO CHWS, PROVIDING TRAINING TO CHW SUPERVISORS/SUPPORT STAFF, AND OFFERING AN IN-DEPTH REGISTERED APPRENTICESHIP PROGRAM WITH PARTNERING CLINICS AND COMMUNITY ORGANIZATIONS. CONTINUING EDUCATION WILL BE PROVIDED TO ALL CHWS TO STAY CURRENT IN PRESSING CHW TOPICS AND ISSUES. OBJECTIVES: IMPROVE HEALTH EQUITY BY PLACING 50 PERCENT OF CHW TRAINEES AND APPRENTICES IN RURAL OR UNDERSERVED AREAS TRAIN 100 NEW CHWS PER YEAR PROVIDE CONTINUING EDUCATION TRAINING TO 33 CHWS PER YEAR TRAIN 5 CHW SUPERVISORS AND/OR SUPPORT STAFF PER YEAR SUPPORT 73 APPRENTICES PER YEAR CLINICAL PRIORITIES: RURAL HEALTH AND HEALTH EQUITY HOW THE PROGRAM WILL BE ACCOMPLISHED: IDAHO STATE UNIVERSITY INITIATED AND HAS ADMINISTERED A CHW CORE TRAINING PROGRAM SINCE 2016. THIS PROJECT ADDS TO THE CHW CORE TRAINING BY IMPLEMENTING AN ADVANCED COURSE, REGISTERED APPRENTICESHIP PROGRAM, AND CONTINUING EDUCATION OPPORTUNITIES THAT WILL BE HOUSED IN THE ISU CHW TRAINING ACADEMY. AVAILABLE TO ALL CHWS STATEWIDE, THE ISU CHW TRAINING ACADEMY’S CORE (48 HOURS) AND ADVANCED COURSES COMBINE ONLINE DIDACTIC INSTRUCTION (48 HOURS) AND EXPERIENTIAL TRAINING (48 HOURS) WHILE THE REGISTERED APPRENTICESHIP PROGRAM PROVIDES IN-DEPTH, ON-THE-JOB TRAINING (2000 HOURS). THE ADVANCED CHW TRAINING AND REGISTERED APPRENTICES HIP OFFERS COMMUNITY- OR CLINIC-BASED TRACKS AS AREAS OF SPECIALIZATION. THOSE CHWS COMPLETING THE ADVANCED CHW TRAINING AND REGISTERED APPRENTICESHIP PROGRAM WILL RECEIVE A FEDERALLY RECOGNIZED CHW CREDENTIAL. APPRENTICES ARE EMPLOYED IN COMMUNITY- OR CLINIC-BASED SITES IN PARTNERSHIP WITH THE EMPLOYER, STATE ASSOCIATIONS THAT ACT AS APPRENTICESHIP SPONSORS (I.E. IDAHO PRIMARY CARE ASSOCIATION, IDAHO ASSOCIATION OF FREE AND CHARITABLE CLINICS, IDAHO COMMUNITY HEALTH WORKER ASSOCIATION, ETC.), OR ISU CLINICS. TO HELP DEFRAY COSTS ASSOCIATED WITH TRAINING, ELIGIBLE CHWS IN THE TRAINING AND APPRENTICESHIP PROGRAMS WILL RECEIVE LIVING STIPENDS. ORGANIZATIONS THAT EMPLOY APPRENTICES ARE ELIGIBLE FOR FINANCIAL INCENTIVES THROUGH THIS PROJECT AND THE IDAHO DEPARTMENT OF LABOR. CHW SUPERVISOR/SUPPORT STAFF TRAINING WILL BE OFFERED TO CHW EMPLOYERS. CONTINUING EDUCATION EFFORTS THROUGH THE PROVISION OF HEALTH SPECIFIC MODULES AND QUARTERLY MINI-LEARNING COLLABORATIVES WILL PROVIDE ONGOING WORKFORCE DEVELOPMENT ON CURRENT TOPICS. THE COMMUNITY HEALTH WORKER ACADEMY AT ISU WILL BUILD THE CHW WORKFORCE, ENCOURAGE THE CREATION OF CHW POSITIONS, AND IMPROVE TRAINING OPPORTUNITIES FOR NEW AND EXISTING CHWS IN IDAHO. TOTAL AMOUNT REQUESTED: $2,995,964

ISU-TRIO TALENT SEARCH SOUTHEASTERN

TAS::89 0222::TAS; ER65130; INVESTIGATIONS OF 18F, 67 CU, 99MO/99TC, AND 131BA/131CS ISOTOPE PRODUCTION; DOUGLAS WELLS, PI

PURPOSE: THE OBJECTIVE OF THE PROJECT IS TO BUILD ON THE STATE-OF-THE-ART LABORATORY FACILITIES DEDICATED TO ADVANCING RESEARCH FOCUSED ON CYBER-INFORMED ENGINEERING (CIE). THE LABORATORY WILL SERVE AS A NEXUS FOR INTERDISCIPLINARY COLLABORATION, INNOVATION, AND KNOWLEDGE DISSEMINATION IN THE FIELDS OF ELECTRICAL ENGINEERING, INDUSTRIAL AUTOMATION, AND SYSTEMS SECURITY ENGINEERING. CIE PROVIDES AN INTERDISCIPLINARY, ENGINEERING-BASED APPROACH TO COUNTERING THE ADVANCED PERSISTENT THREAT BY INCORPORATING PRACTICES FROM SYSTEMS ENGINEERING, CYBERSECURITY, BUSINESS MANAGEMENT, AND MILITARY INTELLIGENCE TO MINIMIZE THE POSSIBILITY OF ADVERSARIES ACHIEVING DEVASTATING IMPACTS AGAINST THE COUNTRY'S MOST CRITICAL SYSTEMS.ACTIVITIES TO BE PERFORMED: EQUIP AN INDUSTRIAL CYBERSECURITY RESEARCH AND TRAINING LABORATORY FOCUSED ON CIE. PROVISION REMOTE ACCESSIBILITY TO THE CYBERSECURITY RESEARCH AND TRAINING LABORATORY. IMPLEMENT HANDS-ON TRAINING USING THE LABORATORY EQUIPMENT. DEMONSTRATE INITIAL RESEARCH ON CIE.EXPECTED OUTCOMES: A FULLY-FUNCTIONAL INDUSTRIAL CYBERSECURITY RESEARCH AND TRAINING LABORATORY. INCREASED STUDENT ACCESS TO RESEARCH AND TRAINING FACILITIES (BOTH ONSITE AND REMOTE). RESEARCH RESULTS FROM CIE ACTIVITIES CONDUCTED WITH THE NEW LABORATORY EQUIPMENT.INTENDED BENEFICIARIES: NIST WILL BENEFIT FROM THE CONDUCT OF CIE RESEARCH MADE POSSIBLE BY THE EQUIPMENT PURCHASED IN THIS GRANT. THE RESEARCH RESULTS WILL INFORM FUTURE NIST SYSTEMS SECURITY ENGINEERING PUBLICATIONS PROVIDING CRITICAL GUIDANCE TO PUBLIC AND PRIVATE SECTOR ORGANIZATIONS. THE APPLICANT WILL BENEFIT BECAUSE THE GRANT WILL PROVIDE FUNDING TO PURCHASE ESSENTIAL EQUIPMENT NECESSARY TO CONDUCT CIE RESEARCH AND PROVIDE AN EFFECTIVE EDUCATION AND TRAINING ENVIRONMENT FOR STUDENTS. THE GENERAL PUBLIC WILL BENEFIT FROM CIE RESEARCH AS IT WILL IDENTIFY WAYS TO MORE EFFECTIVELY PROTECT INDUSTRIAL CONTROL SYSTEMS THAT ARE PART OF THE U.S. CRITICAL INFRASTRUCTURE FROM ADVANCED PERSISTENT THREATS.SUBRECIPIENT ACTIVITIES: THERE ARE NO PLANNED SUBAWARDS.

PRIMARY CARE TRAINING AND ENHANCEMENT-COMMUNITY PREVENTION AND MATERNAL HEALTH

TALENT SEARCH PROGRAM

AREA HEALTH EDUCATION CENTERS (AHEC) PROGRAM - PROJECT TITLE: IDAHO AHEC PROGRAM OFFICE (IDAPO) APPLICANT SCHOOL ORGANIZATION NAME: IDAHO STATE UNIVERSITY DEPARTMENT: SCHOOL OF NURSING STATE: IDAHO ADDRESS: IDAHO STATE UNIVERSITY, 921 S. 8TH AVENUE, STOP 8101, POCATELLO, IDAHO, 83209 PROJECT DIRECTOR NAME: DIANA C. SCHOW, PHD CONTACT PHONE NUMBERS: VOICE: 208-282-2477 FAX: 208-282-2946 EMAIL ADDRESS: SCHODIAN@ISU.EDU WEB SITE ADDRESS: HTTPS://WWW.ISU.EDU/SEIDAHEC/ TOTAL GRANT FUNDS REQUESTED: $3,750,000 PROGRAM PHASE: THE NEWLY PROPOSED IDAPO IS IN THE INFRASTRUCTURE DEVELOPMENT (ID) PHASE. IF FUNDED, IT WILL CONTINUE ACTIVITIES, UNINTERRUPTED, AT IDAHO’S THREE EXISTING CENTERS: NORTH IDAHO AHEC, SOUTHEAST IDAHO AHEC, AND SOUTHWEST IDAHO AHEC. IT WILL ALSO: 1) TRANSFER PREVIOUS PROGRAM OFFICE RESPONSIBILITIES FROM WASHINGTON AHEC TO IDAHO, HOUSED IN IDAHO STATE UNIVERSITY’S (ISU) ACCREDITED SCHOOL OF NURSING, 2) MOVE SOUTHEAST IDAHO AHEC OUT OF ISU TO SOUTHEASTERN IDAHO PUBLIC HEALTH, AND 3) ADD A PROPOSED, SOUTH CENTRAL IDAHO AHEC IN YEAR THREE OF THE FUNDING CYCLE. TWO PLANNING YEARS ARE REQUESTED FOR TRANSITION ACTIVITIES. GEOGRAPHIC AREA/TARGETED POPULATIONS: RURAL AND UNDERSERVED POPULATIONS ACROSS THE STATE OF IDAHO ARE THIS PROJECT’S FOCUS. ADDING A FOURTH CENTER WILL INCREASE IDAPO’S CAPACITY TO REACH THESE POPULATIONS AND MEET WORKFORCE TRAINING NEEDS, ESPECIALLY COMMUNITY HEALTH WORKER TRAINING AND BEHAVIORAL HEALTH INTEGRATION EMPHASIZING THE CLINICAL PRIORITY OF IMPROVING BEHAVIORAL/MENTAL HEALTH ACCESS AND CARE. GOALS, MILESTONES AND OBJECTIVES: EACH YEAR BETWEEN 2022 AND 2027, IDAPO WILL WORK TOWARDS CREATING A DIVERSE AND CULTURALLY COMPETENT, EQUITABLY DISTRIBUTED WORKFORCE THAT IS WELL VERSED IN PRACTICE TRANSFORMATION AND PREPARED TO WORK IN RURAL AND UNDERSERVED AREAS. THE GOALS OF INCREASED VIABILITY, VISIBILITY, AND SUSTAINABILITY OF IDAPO WILL INVOLVE DEVELOPING STRATEGIC PARTNERSHIPS AND ADVISORY GROUPS TO FUND, SUSTAIN AND IMPROVE FOUR CORNERSTONE ACTIVITIES HIGH LIGHTING HRSA PRIORITY TOPICS: 1) THE IDAHO AHEC SCHOLARS PROGRAM, WHICH WILL TRAIN INTERPROFESSIONAL COHORTS OF 15 HEALTH PROFESSIONS STUDENTS ANNUALLY PER CENTER, 2) COMMUNITY-BASED EXPERIENTIAL TRAINING OPPORTUNITIES, LIKE THE RURAL-UNDERSERVED OPPORTUNITIES PROGRAM (RUOP), WHICH WILL SUPPORT FIELD PLACEMENTS, PRECEPTORSHIPS AND OTHER COMMUNITY-BASED ACTIVITIES FOR 20 HEALTH PROFESSIONS STUDENTS ANNUALLY AND PREPARE THEM TO BECOME PROVIDERS IN IDAHO’S HIGH-NEEDS AREAS, 3) FOUR TO EIGHT CONTINUING EDUCATION ACTIVITIES PROVIDED ANNUALLY FOR PRACTICING HEALTH PROFESSIONALS THAT WILL ADDRESS RELEVANT HEALTH ISSUES, AND 4) PATHWAY ACTIVITIES FOR AT LEAST 150 STUDENTS ANNUALLY IN GRADES 9-12 THAT WILL EMPHASIZE PUBLIC HEALTH. OVERVIEW OF PROGRAM PLAN: IDAPO SEEKS TO ADDRESS WORKFORCE SHORTAGES IN PRIMARY CARE, DENTAL, AND MENTAL HEALTH CARE AND MEET SPECIFIC COMMUNITY NEEDS AROUND THE STATE. IT WILL BRING AN IDAHO-CENTRIC FOCUS TO INCREASING THE NUMBER OF HEALTH PROFESSIONS STUDENTS WHO PURSUE CAREERS IN PRIMARY CARE AND MENTAL HEALTH AND ARE PREPARED TO PRACTICE IN RURAL AND UNDERSERVED AREAS. IT WILL IMPLEMENT HEALTH WORKFORCE DEVELOPMENT ACTIVITIES, FUNCTION AS THE STATE’S HUB FOR AHEC CENTERS, ENSURE A QUALITY STATEWIDE EVALUATION PLAN, AND LEVERAGE EXISTING STRATEGIC PARTNERSHIPS WITH ORGANIZATIONS LIKE THE IDAHO PRIMARY CARE ASSOCIATION TO ENSURE SUSTAINABILITY. PROJECT EVALUATION PLAN: THROUGH REGULAR COMMUNICATION USING A RAPID-CYCLE ASSESSMENT PROCESS, IDAPO AND AHEC CENTERS WILL COMPLETE FORMATIVE AND SUMMATIVE EVALUATIONS USING METHODS SUCH AS PRE-POST SURVEYS AND INTERVIEWS TO EVALUATE INDIVIDUAL AND AGGREGATE OUTCOMES ON DIVERSITY, DISTRIBUTION AND PRACTICE TRANSFORMATION IN IDAHO. YEAR-OVER-YEAR GAINS WILL BE SOUGHT IN NUMBER AND TYPE OF PARTICIPANTS, SATISFACTION, KNOWLEDGE, APPLICATION, AND IMPACT. EVALUATION ACTIVITIES WILL ALSO FOCUS ON THE SUPPLY AND DISTRIBUTION OF THE STATE’S HEALTH WORKFORCE. ALL DATA WILL BE COLLECTED A

TALENT SEARCH PROGRAM

BUILDING CONSTRUCTION

IDAHO STATE UNIVERSITY COLLEGE ASSISTANCE MIGRANT PROGRAM (CAMP)

CYBERCORPS SCHOLARSHIP FOR SERVICE (RENEWAL): INTERDISCIPLINARY SCHOLARSHIP FOR SERVICE FOR THE INTERMOUNTAIN WEST -IN 1998, IDAHO STATE UNIVERSITY (ISU) WAS AMONG THE COUNTRY?S FIRST NATIONAL SECURITY AGENCY (NSA)-DESIGNATED CENTERS OF ACADEMIC EXCELLENCE IN INFORMATION ASSURANCE (NOW CYBER DEFENSE). ISU HAS OFFERED THE SCHOLARSHIP FOR SERVICE (SFS) CONTINUALLY SINCE 2003 ? OVER WHICH TIME IT HAS PRODUCED 100 CYBERSECURITY PROFESSIONALS FOR FEDERAL GOVERNMENT ORGANIZATIONS. ISU SFS GRADUATES HAVE GONE ON TO BECOME CHIEF INFORMATION SECURITY OFFICERS (CISOS) IN EXECUTIVE BRANCH AGENCIES, ENTREPRENEURS, AND ACADEMICS, CONTRIBUTING TO A ROBUST CYBERSECURITY ECOSYSTEM THAT SUPPORTS NATIONAL SECURITY AND SCIENTIFIC COMMUNITY. THIS PROJECT EXTENDS ISU?S COMMITMENT TO DEFEND NATIONAL SECURITY BY PRODUCING QUALIFIED, ADAPTABLE AND INTERDISCIPLINARY GRADUATES FOR FEDERAL EMPLOYMENT OVER THE NEXT FIVE YEARS. IN ORDER TO ACHIEVE ITS GOAL, ISU WILL SELECT HIGHLY MOTIVATED, HIGH-PERFORMING STUDENTS FROM DIVERSE ACADEMIC BACKGROUNDS. SELECTED SFS SCHOLARS WILL ENGAGE IN A COHORT-BASED, EDUCATION-PROFESSIONAL EXPERIENCE. THEY WILL BE ENGAGED IN SOLVING COMPLEX CYBERSECURITY CHALLENGES, INCLUDING PLANNING, DESIGNING, AND CARRYING OUT AN ANNUAL CYBERSECURITY COMPETITION IN REGIONAL INSTITUTIONS OF HIGHER EDUCATION. SFS SCHOLARS WILL LEARN CYBERSECURITY STRATEGY, FEDERAL POLICY, RISK MANAGEMENT, AND INCIDENT RESPONSE FROM QUALIFIED FACULTY AND STAFF IN FORMAL CLASSROOM SETTINGS. SFS SCHOLARS WILL BE ABLE TO APPLY THEIR KNOWLEDGE TO SOLVE CURRENT AND FUTURE CHALLENGES THROUGH RESEARCH OPPORTUNITIES, CYBERSECURITY COMPETITIONS, AND A FINAL CYBERSECURITY PROJECT. SFS SCHOLARS WILL INTERACT REGULARLY WITH ISU SFS ALUMNI, WHO CAN PROVIDE SCHOLARSHIP RECIPIENTS WITH RELEVANT AND TIMELY INSIGHTS ABOUT FEDERAL SERVICE IN THE CYBERSECURITY FIELD. SFS SCHOLARS WILL PREPARE FOR AND TAKE EXTERNALLY VALIDATED PROFESSIONAL CERTIFICATION EXAMS, SUCH AS SECURITY+ AND CISSP. ISU SFS SCHOLARS WILL SERVE AS INTERNS FOR AND ACCEPT EMPLOYMENT IN THE FEDERAL EXECUTIVE BRANCH. THIS PROJECT IS SUPPORTED BY THE CYBERCORPS? SCHOLARSHIP FOR SERVICE (SFS) PROGRAM, WHICH FUNDS PROPOSALS ESTABLISHING OR CONTINUING SCHOLARSHIP PROGRAMS IN CYBERSECURITY AND ALIGNS WITH THE U.S. NATIONAL CYBER STRATEGY TO DEVELOP A SUPERIOR CYBERSECURITY WORKFORCE. FOLLOWING GRADUATION, SCHOLARSHIP RECIPIENTS ARE REQUIRED TO WORK IN CYBERSECURITY FOR A FEDERAL, STATE, LOCAL, OR TRIBAL GOVERNMENT ORGANIZATION FOR THE SAME DURATION AS THEIR SCHOLARSHIP SUPPORT.?? THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

HIGH SCHOOL EQUIVALENCY PROGRAM

IDAHO STATE UNIVERSITY UPWARD BOUND ORIGINAL

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

MOLECULAR ANALYSIS OF MALARIA MITOCHONDRIAL GENE REGULATION - THE HUMAN MALARIA PARASITE, PLASMODIUM FALCIPARUM, RAPIDLY EVOLVES DRUG RESISTANCE, CREATING THE URGENT NEED FOR NEW TREATMENT STRATEGIES. A CRITICAL BARRIER TO IDENTIFYING AND DEVELOPING NEW DRUG DEVELOPMENT TARGETS IS A KNOWLEDGE GAP REGARDING MOST ESSENTIAL PROCESSES AND REGULATORY PATHWAYS. IDEALLY, NEW TARGETS SHOULD BE HIGHLY CONSERVED AND BE UNABLE OR HAVE LIMITED ABILITY TO MUTATE IN ORDER TO EVOLVE RESISTANCE. PARASITE MITOCHONDRIAL FUNCTION IS CRITICALLY ESSENTIAL ACROSS ALL THE LIFE STAGES AND DIFFERS SUBSTANTIALLY FROM THE HUMAN ORGANELLE; HOWEVER, MOST MITOCHONDRIAL PROTEINS HAVE YET TO BE IDENTIFIED IN MALARIA PARASITES. DURING THE INTRAERYTHROCYTIC DEVELOPMENT CYCLE (IDC), P. FALCIPARUM IS SUPPORTED BY A SINGLE MITOCHONDRION CONTAINING ABOUT ~20 COPIES OF THE 6 KB GENOME, CHARACTERIZED BY EXTENSIVE RECOMBINATION. IDC PARASITE MITOCHONDRIA DO NOT MAKE CRISTAE TO INSERT ELECTRON TRANSPORT CHAIN (ETC) ENZYMES, THUS THE ORGANELLE MAY HAVE EVOLVED UNIQUE TRANSCRIPTION OR TRANSLATION REPRESSION SYSTEMS TO LIMIT EXPRESSION OF THE MITOCHONDRIAL ENCODED GENES. RESULTS FROM OUR INTEGRATIVE APPROACH COMBINING WHOLE GENOME SEQUENCING AND METABOLIC PROFILING, SUGGESTS A LINK BETWEEN MITOCHONDRIAL GENE EXPRESSION REGULATION AND RESISTANCE TO ETC INHIBITORS, POTENTIALLY DUE TO RECOMBINATION. THUS, WE HYPOTHESIZE THAT 1) A FEATURE OF THE MULTICOPY STATUS IS RETENTION OF CRYPTIC MITOCHONDRIAL GENOME COPIES ENCODING MUTANT ALLELES, WHICH CAN BE RECOMBINED FOR SURVIVAL. 2) P. FALCIPARUM MITOCHONDRIA USE PREVIOUSLY UNCHARACTERIZED GENE EXPRESSION SYSTEMS, FOR REPRESSION AND ACTIVATION WHICH ARE UNIQUE TO THIS ORGANELLE. THE CURRENT OBJECTIVES ARE TO IDENTIFY THE SOURCE OF RECOMBINATION BETWEEN MITOCHONDRIAL GENOMES AND ITS CONTRIBUTION TO DRUG RESISTANCE AS WELL AS TO DETERMINE THE MITOCHONDRIAL DNA REPAIR PATHWAYS AND TRANSCRIPTIONAL MACHINERY OF THE MITOCHONDRIA USING SINGLE-ORGANELLE APPROACHES. THIS PROPOSAL WILL IDENTIFY AND DEFINE PREVIOUSLY UNKNOWN AND UNCHARACTERIZED ASPECTS OF PARASITE BIOLOGY, WITH THE GOAL OF ADVANCING RATIONAL DRUG DESIGN. THESE STUDIES WILL REFINE OUR KNOWLEDGE ABOUT THE BASIC MECHANISM OF GENE REGULATION IN THE MALARIA MITOCHONDRIA. INVESTIGATING THE MECHANISMS UNDERPINNING THESE EFFECTS WILL LEAD TO THE IDENTIFICATION OF HIGHLY CONSERVED DRUG DEVELOPMENT TARGETS.

COMMUNITY BASED JOB TRAINING

THE BRAIN-BEHAVIOR RELATIONSHIP: AGE, HEARING, AND THEIR EFFECTS ON UNDERSTANDING SPEECH IN NOISE

ENHANCE HEALTHCARE INTERPRETING TO ADVANCE HEALTH EQUITY FOR DEAF/DEAFBLIND/HARD OF HEARING INDIVIDUALS

BASIC RESEARCH IN HIGH SENSITIVITY SNM FORENSICS VIA CORRELATED PHOTO-INDUCED EMISSION SIGNATURES FOR TOPIC B: ADVANCED RADIOLOGICAL DETECTION &...

CONTINUING, GK-12: ENHANCING SCIENCE LITERACY IN SOUTHEAST IDAHO WITH COMMUNITY-BASED PROJECTS AND UNIVERSITY/K-12 PARTNERSHIPS

RESIDENCY TRAINING IN PRIMARY CARE

UPWARD BOUND

UPWARD BOUND PROGRAM

SYNTHESIS AND CHARACTERIZATION OF WIDE BAND GAP SEMICONDUCTORS FOR OPTOELECTRONIC APPLICATIONS

IDAHO STATE UNIVERSITY UPWARD BOUND

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

IDAHO STATE UNIVERSITY TRIO STUDENT SUPPORT SERVICES -CLASSIC

NURSE EDUCATION PRACTICE AND RETENTION: PURPOSE E2

TIMELY RESPONSE TO IN-HOSPITAL DETERIORATION THROUGH DESIGN OF ACTIONABLE AUGMENTED INTELLIGENCE

SLEEP PHYSIOLOGY AND RISK FOR ALCOHOL PROBLEMS IN CHILDREN OF ALCOHOLICS

IDAHO ACCELERATOR CENTER ADVANCED FUEL CYCLE RESEARCH

PRIMARY CARE TRAINING AND ENHANCEMENT: PHYSICIAN ASSISTANT RURAL TRAINING PROGRAM

NURSE EDUCATION, PRACTICE, QUALITY, AND RETENTION - INTERPROFESSIONAL COLLBORATIVE PRACTICE

STUDENT SUPPORT SERVICES PROGRAM

IDAHO AWARENESS TO ACT YOUTH SUICIDE PREV EARLY INTRVTN PROJ

SUPPORTING TRANSFER STUDENT SUCCESS USING A MULTIDISCIPLINARY APPROACH -THIS PROJECT WILL CONTRIBUTE TO THE NATIONAL NEED FOR WELL-EDUCATED SCIENTISTS, MATHEMATICIANS, ENGINEERS, AND TECHNICIANS BY SUPPORTING THE RETENTION AND GRADUATION OF HIGH-ACHIEVING, LOW-INCOME STUDENTS WITH DEMONSTRATED FINANCIAL NEED AT IDAHO STATE UNIVERSITY. OVER ITS 6-YEAR DURATION, THIS PROJECT WILL PROVIDE SCHOLARSHIPS TO 36-45 DIFFERENT FULL-TIME TRANSFER STUDENTS WHO ARE PURSUING BACHELOR?S DEGREES IN BIOLOGY, MICROBIOLOGY, BIOCHEMISTRY, OR CHEMISTRY (BMBC). FOUR COHORTS OF SCHOLARS WILL RECEIVE UP TO TWO AND A HALF YEARS OF SCHOLARSHIP SUPPORT. TO FACILITATE DEGREE COMPLETION AND TRANSITION TO THE STEM WORKFORCE, SCHOLARSHIP SUPPORT WILL BE COUPLED WITH OTHER SUPPORTS TO STRUCTURE SCHOLARS? AUTHENTIC PARTICIPATION IN A MULTIDISCIPLINARY RESEARCH COMMUNITY OVER TIME, INCLUDING A RESEARCH EXPLORATION COURSE TO HIGHLIGHT MULTIDISCIPLINARY STRATEGIES TO DIVERSE BMBC RESEARCH PROBLEMS, AN UNDERGRADUATE RESEARCH EXPERIENCE, FACULTY AND PEER MENTORING STRUCTURES TO PROMOTE SCHOLARS? SENSE OF BELONGING IN THE BMBC RESEARCH COMMUNITY, AND CONNECTIONS TO POST-GRADUATION WORKFORCE AND GRADUATE PROGRAM PLACEMENT. THIS PROJECT HAS THE POTENTIAL TO IMPROVE THE STEM WORKFORCE BY PREPARING SCIENTIST LEADERS FOR MULTIDISCIPLINARY TEAMS WHO CAN IDENTIFY EMERGING RESEARCH AREAS AND DEVISE INNOVATIVE SOLUTIONS TO PROBLEMS ACROSS THE BIOLOGY-CHEMISTRY INTERFACE. THE OVERALL GOAL OF THIS PROJECT IS TO INCREASE STEM DEGREE COMPLETION OF LOW-INCOME, HIGH-ACHIEVING UNDERGRADUATES WITH DEMONSTRATED FINANCIAL NEED. THE SPECIFIC OBJECTIVES OF THIS PROJECT ARE TO PROVIDE SCHOLARSHIPS TO STUDENTS TRANSFERRING TO A BMBC MAJOR AT IDAHO STATE UNIVERSITY, IMPROVE TRANSFER STUDENT RETENTION AND ON-TIME GRADUATION, AND TRAIN SCIENTIST LEADERS OF MULTIDISCIPLINARY TEAMS. TRANSFER STUDENTS FACE THE SPECIFIC CHALLENGE OF TRANSITIONING TO A NEW ACADEMIC SPACE WITH LIMITED TIME TO AUTHOR THEIR IDENTITIES IN RELATION TO THAT SPACE, WHICH IS IMPORTANT FOR STUDENT PERSISTENCE IN A DISCIPLINE. TO ADDRESS THIS CHALLENGE, THIS PROJECT WILL DRAW ON EVIDENCE-BASED APPROACHES FROM TWO FRAMEWORKS: COMMUNITIES OF SCIENCE PRACTICE AND DISCIPLINARY IDENTITY. THE PROJECT ACTIVITIES WILL BE DESIGNED TO SUPPORT TRANSFER STUDENTS TO AUTHOR THEIR MULTIDISCIPLINARY IDENTITIES THROUGH PARTICIPATION IN THE BMBC COMMUNITY OF SCIENCE PRACTICE. THIS PROJECT HAS THE POTENTIAL TO ADVANCE UNDERSTANDING OF THE EFFECTIVENESS OF THESE EVIDENCE-BASED APPROACHES IN THIS CONTEXT FOR TRANSFER STUDENT RETENTION AND GRADUATION IN BMBC MAJORS AND TRANSITION TO THE STEM WORKFORCE OR GRADUATE PROGRAMS. THE PROJECT WILL BE EVALUATED BASED ON THE ANALYSIS OF INSTITUTIONAL DATA, SCHOLAR SURVEYS, SCHOLAR FOCUS GROUP INTERVIEWS, AND FACULTY SURVEYS. AN EXTERNAL EVALUATOR WILL CONDUCT YEARLY FORMATIVE ASSESSMENT AND A SUMMATIVE ASSESSMENT AT THE END OF THE PROJECT TO ASSESS HOW THE PROJECT MEETS THE OBJECTIVES. RESULTS OF THIS PROJECT WILL BE DISSEMINATED THROUGH PRESENTATIONS AT REGIONAL AND NATIONAL CONFERENCES, PEER-REVIEWED PUBLICATIONS, A DEDICATED SECTION ON THE UNIVERSITY WEBSITE, UNIVERSITY PRESENTATIONS, AND DEPARTMENT SEMINARS. THIS PROJECT IS FUNDED BY NSF?S SCHOLARSHIPS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS PROGRAM, WHICH SEEKS TO INCREASE THE NUMBER OF LOW-INCOME ACADEMICALLY TALENTED STUDENTS WITH DEMONSTRATED FINANCIAL NEED WHO EARN DEGREES IN STEM FIELDS. IT ALSO AIMS TO IMPROVE THE EDUCATION OF FUTURE STEM WORKERS, AND TO GENERATE KNOWLEDGE ABOUT ACADEMIC SUCCESS, RETENTION, TRANSFER, GRADUATION, AND ACADEMIC/CAREER PATHWAYS OF LOW-INCOME STUDENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

PHYSICIAN ASSISTANT TRAINING IN PRIMARY CARE

THE PROPOSED PROJECT IS A COMMUTER-RESIDENTIAL HIGH SCHOOL EQUIVALENCY PROGRAM (HEP) ADMINISTERED BY IDAHO STATE UNIVERSITY (ISU).

STUDENT SUPPORT SERVICES PROGRAM

VETERANS UPWARD BOUND

ISU-TRIO TALENT SEARCH MAGIC VALLEY

ISU-TRIO EOC MAGIC VALLEY

TRAUMATIC BRAIN INJURY IMPLEMENTATION

IDAHO STATE UNIVERSITY UPWARD BOUND MATH SCIENCE

IDAHO STATE UNIVERSITY NANORAD POWER PACK

SMART PROSTHETIC HAND TECHONOLGY-PHASE II

TALENT SEARCH PROGRAM

PRIMARY CARE TRAINING AND ENHANCEMENT - LANGUAGE AND DISABILITY ACCESS - ADDRESS: 1311 E. CENTRAL DR., MERIDIAN, ID 83642 PROJECT DIRECTOR: CHRISTINE M. HALL, MPAS, PA-C, DIPACLM, CONTACT NUMBERS: PHONE: (208) 412-8305, FAX: (208) 373-1786 EMAIL ADDRESS: CHRISTINEHALL@ISU.EDU PHYSICIAN ASSISTANT STUDIES WEBSITE: HTTPS://WWW.ISU.EDU/PA/ FUNDING REQUESTED: $1,643,855 TOTAL DIRECT COSTS. $92,917 INDIRECT COSTS. FUNDING PREFERENCE: HIGH MUC PLACEMENT RATE FOCUS AREA: PATIENTS WITH LIMITED ENGLISH PROFICIENCY PRIMARY CARE TRAINEES: PHYSICIAN ASSISTANT STUDENTS SUMMARY: CENSUS DATA SHOWS THAT 10.4% OF IDAHO’S POPULATION 5 YEARS OF AGE AND OLDER USES ONE OF 94 PRIMARY LANGUAGES OTHER THAN ENGLISH OR SPANISH. IDAHO’S POPULATIONS WITH LIMITED ENGLISH PROFICIENCY (LEP) ARE INCREASINGLY DIVERSE AND GROWING. THE PHYSICIAN ASSISTANT LIMITED ENGLISH ADVOCACY PROJECT (PALEAP) IS DESIGNED TO MEET THE HEALTHCARE WORKFORCE GOAL OF INCREASING THE NUMBER OF PRIMARY CARE PHYSICIAN ASSISTANT (PA) STUDENTS PREPARED TO PROVIDE CULTURALLY AND LINGUISTICALLY APPROPRIATE CARE AND SERVICES TO INDIVIDUALS WITH LEP. PHYSICIAN ASSISTANTS (PAS) IN IDAHO NEED COMMUNICATIVE PROFICIENCY IN MEDICAL SPANISH, EXPERIENCE USING INTERPRETERS TO SERVE LINGUISTICALLY DIVERSE POPULATIONS, AND FAMILIARITY WITH LANGUAGE AND ADVOCACY RESOURCES TO CARE FOR THE GROWING NUMBER OF PEOPLE WITH LEP IN OUR STATE AND OUR REGION. PALEAP WILL 1) INCREASE THE NUMBER OF PRIMARY CARE PAS TRAINED TO PROVIDE LINGUISTICALLY AND CULTURALLY APPROPRIATE CARE AND SERVICES TO SPANISH SPEAKING INDIVIDUALS WITH LEP, INCLUDING THOSE WITH LOW HEALTH LITERACY, 2) DEVELOP AND IMPLEMENT A CULTURALLY COMPETENT DIDACTIC AND CLINICAL CURRICULUM TO EDUCATE PRIMARY CARE TRAINEES, FACULTY, AND PRECEPTORS TO CARE FOR INDIVIDUALS WITH LEP, 3) PROVIDE OPPORTUNITIES FOR CLINICAL TRAINING IN COMMUNITY-BASED SETTINGS WHERE PA STUDENTS CAN CARE FOR INDIVIDUALS WITH LEP, 4) TRAIN PAS TO WORK WITH INTERPRETERS AND ACCESS LANGUAGE SUPPORT RESOURCES THAT WILL INCREASE LEP ACCESS TO CARE, ADVOCATE FOR HEAL TH LITERACY AND INCREASE SELF-EFFICACY AMONG LEP PATIENTS. PALEAP’S PROJECT DESIGN AND ACTIVITIES REFLECT RESEARCH-DRIVEN STRATEGIES FOR PRODUCING PAS COMMITTED TO PRACTICE IN UNDERSERVED COMMUNITIES AND WITH THE SKILLS NEEDED TO SERVE INDIVIDUALS WITH LEP. THE PALEAP PROJECT WILL: 1) INCREASE THE NUMBER OF PRIMARY CARE TRAINEES (PA STUDENTS) WHO ARE TRAINED TO PROVIDE CULTURALLY COMPETENT AND LINGUISTICALLY APPROPRIATE CARE AND SERVICES IN SPANISH TO SPANISH-SPEAKING INDIVIDUALS WITH LEP; 2) CREATE PARTNERSHIPS WITH LEP SERVING COMMUNITY-ORGANIZATIONS TO STRENGTHEN AND EXPAND THE PAS DIDACTIC AND CLINICAL CURRICULUM TO PREPARE PAS WHO ARE COMPETENT AND CONFIDENT IN PROVIDING CULTURALLY AND LINGUISTICALLY APPROPRIATE HEALTH CARE SERVICES FOR DIVERSE POPULATIONS WITH LEP, INCLUDING HISPANIC AND NON-HISPANIC INDIVIDUALS; 3) PARTNER WITH 4 COMMUNITY-BASED CLINICS SERVING HISPANICS WITH LEP AND NON-SPANISH-SPEAKING LEP POPULATIONS TO PROVIDE 10-WEEK LONGITUDINAL PA CLINICAL ROTATION SITES IN COMMUNITY-BASED SETTINGS PROVIDING CARE AND ADVOCACY FOR INDIVIDUALS WITH LEP.

CDI-TYPE II COLLABORATIVE RESEARCH: UNDERSTANDING SOCIAL NETWORKS, COMPLEX SYSTEMS

IDAHO ACCELERTOR CENTER (AIC) GENERAL ATOMICS (GA) LASER COMPTON SCATTERING UPGRADE

IDAHO STATE UNIVERSITY SCHOLARSHIP FOR SERVICE 2008 PROJECT

EDUCATIONAL OPPORTUNITY CENTERS PROGRAM

TRIO MCNAIR PROGRAM

IDAHO STATE UNIVERSITY SFS 2011 GRANT APPLICATION

IDAHO STATE UNIVERSITY TRIO VETERANS UPWARD BOUND

ISU-TRIO UPWARD BOUND MATH SCIENCE

NEW; TITLE: INVESTIGATIONS OF 18F, 67CU, 99MO/99TC, AND 131BA/131CS ISOTOPE PRODUCTION WITH PHOTO-NUCLEAR REACTIONS; PI: DOUGLAS WELLS

THIS AWARD APPROVES FUNDING FOR THE 2023-2024 SEPTEMBER 11TH NATIONAL DAY OF SERVICE AND REMEMBRANCE PROGRAM DESCRIBED IN THE APPROVED PROGRAM NARRATIVE AND BUDGET. YOUR 2023-24 REGULATORY MATCH IS 0%.

PRECISION ELECTROWEAK PROBES OF NEUTRON-RICH MATTER AND BSM PHYSICS

IDAHO MAKING PROGRESS ADDRESSING CRITICAL TEACHER SHORTAGES IN STEM -THE PROJECT AIMS TO SERVE THE NATIONAL NEED OF PREPARING HIGHLY QUALIFIED STEM TEACHERS. TO HELP ADDRESS THE CRITICAL SHORTAGE OF HIGHLY QUALIFIED STEM TEACHERS, THIS PROJECT WILL RECRUIT STEM MAJORS TO BECOME SECONDARY STEM TEACHERS TO TEACH IN RURAL AND HIGH-NEED SCHOOL DISTRICTS. THROUGH A FOUR-PHASE PROCESS TO DEVELOP A ROBUST COMMUNITY OF PRACTICE, THE PROJECT WILL SUPPORT AND MENTOR NOYCE SCHOLARS FROM THEIR INITIAL DEVELOPMENT AS A PROSPECTIVE STEM TEACHER THROUGH THEIR CONTINUING GROWTH AS A PRACTICING STEM TEACHER. NOYCE SCHOLARS WILL HAVE THE OPPORTUNITY TO EARN A MASTER OF ARTS IN TEACHING DEGREE ALONGSIDE THEIR TEACHING CERTIFICATION. IN ADDITION, THE PROGRAM WILL SUPPORT FIRST-YEAR AND SOPHOMORE STUDENTS TO PARTICIPATE IN INTERNSHIPS TO INTRODUCE THEM TO K-12 STEM EDUCATION FOLLOWED BY MORE EXTENSIVE FIELD EXPERIENCES AS NOYCE SCHOLARS. STRONG SCHOOLS WITHIN LOCAL COMMUNITIES ARE A CENTRAL ELEMENT TO AN INFORMED DEMOCRACY AND STRONG, HIGHLY QUALIFIED STEM TEACHERS CAN MEANINGFULLY CONTRIBUTE TO CREATING STRONG SCHOOLS. THIS PROJECT AT IDAHO STATE UNIVERSITY INCLUDES PARTNERSHIPS WITH THE SHOSHONE-BANNOCK TRIBE, THE AMERICAN FALLS SCHOOL DISTRICT, AND THE POCATELLO/CHUBBUCK SCHOOL DISTRICTS, ALL OF WHICH ARE HIGH-NEED DISTRICTS. PROJECT GOALS INCLUDE: 1) INCREASING THE NUMBER OF HIGHLY QUALIFIED K-12 STEM TEACHERS IN IDAHO AND THE INTERMOUNTAIN-WEST REGION, AND 2) CREATING EFFECTIVE SUPPORT AND MENTORING STRUCTURES BETWEEN IDAHO STATE UNIVERSITY (ISU) STEM DEPARTMENTS AND THE COLLEGE OF EDUCATION. TO THIS END, THIS PROJECT WILL SUPPORT 26 UNDERGRADUATE AND GRADUATE LEVEL SCHOLARS OVER THE LIFETIME OF THE PROJECT. ISU WILL IMPLEMENT A FOUR-PHASE COMMUNITIES OF PRACTICE FOR STEM SCHOLARS CONSISTING OF: 1) INTERNAL EXPERIENCES, 2) EXTERNAL EXPERIENCES, 3) LEADERSHIP OPPORTUNITIES, AND 4) ON-GOING, CLASSROOM-BASED MENTORING AND PROFESSIONAL DEVELOPMENT. PHASE ONE WILL IMPLEMENT INTERNAL STEM AND STEM EDUCATION EXPERIENCES SUCH AS, TEACHING ASSISTANTSHIPS, CONTENT MENTORING WITH STEM FACULTY, AND AN ISU NOYCE STEM STUDENT TEAM TO RECRUIT AND DEVELOP A COMMUNITY OF PRACTICE IN STEM EDUCATION. PHASE TWO WILL ENGAGE SCHOLARS WITH THE EDUCATION COMMUNITY BY SUPPORTING SECONDARY STEM CLASSROOMS AND STEM OUTREACH ACTIVITIES SUCH AS STEM CAMPS FOR SECONDARY STUDENTS. PHASE THREE AIMS TO BUILD NOYCE SCHOLARS' LEADERSHIP SKILLS BY LEADING ISU NOYCE STEM STUDENT TEAM, CO-FACILITATING PROFESSIONAL DEVELOPMENT FOR INCOMING NOYCE SCHOLARS, AND PRESENTING AT CONFERENCES WITH CURRENT STEM AND EDUCATION PRACTITIONERS. PHASE FOUR INTENDS TO SUPPORT AND NURTURE NEW NOYCE TEACHERS IN THE CLASSROOM WITH SITE-BASED MENTORING, REMOTE NETWORKING, AND ANNUAL REUNIONS FOR CONTINUED PROFESSIONAL LEARNING. THIS PROJECT WILL POTENTIALLY DEVELOP UNDERSTANDINGS OF THE ROLE AND EFFECT OF RECRUITMENT AND RETENTION ACTIVITIES, COLLABORATIVE STRUCTURES, AND DEVELOP EVIDENCE-BASED PATHWAYS IN CONSTRUCTING PROGRAMS TO DEVELOP AND SUSTAIN STEM EDUCATORS FOR HIGH-NEED, RURAL, AND INTERMOUNTAIN-WEST REGION SCHOOLS. PROJECT RESULTS WILL BE EVALUATED THROUGH BOTH QUALITATIVE AND QUANTITATIVE MEANS (E.G. FIELD NOTES, INTERVIEWS, SURVEYS) AND WILL BE SHARED THROUGH PUBLICATIONS AND PRESENTATIONS AT CONFERENCES. THIS TRACK 1: SCHOLARSHIPS AND STIPENDS PROJECT IS SUPPORTED THROUGH THE ROBERT NOYCE TEACHER SCHOLARSHIP PROGRAM (NOYCE). THE NOYCE PROGRAM SUPPORTS TALENTED STEM UNDERGRADUATE MAJORS AND PROFESSIONALS TO BECOME EFFECTIVE K-12 STEM TEACHERS AND EXPERIENCED, EXEMPLARY K-12 TEACHERS TO BECOME STEM MASTER TEACHERS IN HIGH-NEED SCHOOL DISTRICTS. IT ALSO SUPPORTS RESEARCH ON THE EFFECTIVENESS AND RETENTION OF K-12 STEM TEACHERS IN HIGH-NEED SCHOOL DISTRICTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM - THE IDAHO BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM (THE I-BHWET) IS A RESPONSE TO THE SEVERE BEHAVIORAL HEALTH WORKFORCE SHORTAGE IN IDAHO, PARTICULARLY IN RURAL AREAS AND AMONGST MINORITIZED POPULATIONS. THE ENTIRE STATE OF IDAHO IS A MENTAL HEALTH SHORTAGE AREA, AND ITS RESIDENTS FACE A SUICIDE RATE ABOVE THE NATIONAL AVERAGE. CHILDREN AND ADOLESCENTS ACROSS IDAHO ALSO EXPERIENCE SERIOUS MENTAL HEALTH CHALLENGES, LIKE SUICIDAL IDEATION AND MAJOR DEPRESSIVE EPISODES, WHICH ARE OFTEN MADE WORSE BY SOCIO-ECONOMIC DIFFICULTIES. IDAHOANS NEED TEAM-BASED, INTEGRATED BEHAVIORAL HEALTH SERVICES PROVIDED BY MENTAL HEALTH COUNSELORS WHO UNDERSTAND AND ARE COMMITTED TO THEIR LOCAL COMMUNITIES. THUS, THE I-BHWET WILL RECRUIT COUNSELING TRAINEES FROM RURAL AND UNDERSERVED COMMUNITIES ACROSS IDAHO FOR IDAHO STATE UNIVERSITY’S (ISU) MASTERS IN COUNSELING PROGRAM AND THE I-BHWET. THESE TRAINEES WILL HAVE AN INTEREST IN WORKING WITH CHILDREN, ADOLESCENTS, AND YOUNG ADULTS, AND WILL EACH CONDUCT AT LEAST 360 HOURS OF COUNSELING IN A HIGH-NEED, HIGH-DEMAND SETTING DURING THEIR YEAR IN THE I-BHWET. I-BHWET TRAINEES WILL ALSO COMMIT TO COUNSELING FOR AT LEAST ONE YEAR IN A HIGH-NEED, HIGH-DEMAND SETTING IN IDAHO POST-GRADUATION. THE I-BHWET WILL ALSO EXPAND ISU’S COMMUNITY PARTNERSHIPS WITH EXPERIENTIAL TRAINING SITES IN HIGH-NEED AND HIGH-DEMAND AREAS, AND THE NUMBER OF CLINICAL SUPERVISORS PREPARED TO SUPPORT AND MENTOR TRAINEES. TRAINEES AND SUPERVISORS WILL ENGAGE IN TEAM-BASED, COLLABORATIVE TRAINING AND EDUCATION TO FURTHER INTEGRATE BEHAVIORAL HEALTHCARE INTO INTERPROFESSIONAL PRIMARY CARE SETTINGS. TRAINEES AND SUPERVISORS WILL ALSO PARTICIPATE IN SUPERVISION TRAINING FOCUSED ON CHILDREN, ADOLESCENTS, AND YOUNG ADULTS IN PARTICULAR. THESE TRAININGS WILL EXPAND SUPERVISORS’ READINESS TO SUPPORT TRAINEES IN INTEGRATED AND INTERPROFESSIONAL SETTINGS, AND INCREASE TRAINEES’ INTEREST AND PREPAREDNESS TO SERVE AS SUPERVISORS IN THE FUTURE. THE I-BHWET IS REQUESTING FUNDING PRIORITY 1 AND FUNDING PREFERENCE 1. SEE FURTHER DETAIL IN ATTACHMENT 8.

GRADUATE PSYCHOLOGY EDUCATION PROGRAMS

RESIDENCY TRAINING IN PRIMARY CARE

ISU BRIDGES TO RESEARCH CAREERS - SUMMARY PATHWAYS TO BIOMEDICAL CAREERS ARE EXCEPTIONALLY DIFFICULT FOR FIRST GENERATION, LIMITED INCOME COLLEGE STUDENTS AND OTHER UNDERGRADUATE STUDENTS FROM UNDERREPRESENTED POPULATIONS. STUDENT LEARNING AND PROFESSIONAL DEVELOPMENT RESEARCHERS HAVE IDENTIFIED A CRITICAL ROLE FOR AN INCLUSIVE RESEARCH EDUCATION COMMUNITY (IREC) IN THE DEVELOPMENT OF YOUNG SCIENTISTS. THE LONG-TERM GOAL OF THE PROPOSED PROGRAM IS TO HELP STUDENTS GAIN NECESSARY SKILLS, EMBRACE AN IDENTITY AS A SCIENTIST, JOIN A COMMUNITY OF SCIENTISTS, AND EMBARK ON A BIOMEDICAL CAREER. TO ACCOMPLISH THIS, THE INVESTIGATORS WILL CREATE THE ISU BRIDGES TO RESEARCH CAREERS (BRC) PROGRAM. THE OBJECTIVE OF THIS GRANT IS TO CREATE A PATHWAY TO BIOMEDICAL CAREERS FOR UNDERGRADUATE STUDENTS FROM UNDERREPRESENTED POPULATIONS BY INTERWEAVING A MENTORING PROGRAM FOR FRESHMEN COLLEGE STUDENTS FROM UNDERREPRESENTED POPULATIONS; A BACTERIOPHAGE DISCOVERY & BIOINFORMATICS COURSE DEVELOPING BIOMEDICAL RESEARCH SKILLS USING AN NIAID-RELEVANT MODEL SYSTEM; AND A BIOMEDICAL RESEARCH NETWORK THAT WILL PROVIDE AUTHENTIC RESEARCH OPPORTUNITIES FOR PARTICIPANTS IN LABS CONDUCTING NIAID-RELEVANT RESEARCH. THE PROPOSED BRC PROGRAM WILL EFFECTIVELY REACH UNDERGRADUATES EARLY IN THEIR COLLEGE CAREER AND GUIDE THEM AS THEY DEVELOP INTO SCIENTISTS AND EMBARK ON BIOMEDICAL CAREERS. THE PROGRAM EFFICIENTLY LEVERAGES EXISTING ACTIVITIES, PROVIDING TANGIBLE OPPORTUNITIES FOR UNDERSERVED IDAHOANS AND TRAINING PARTICIPANTS TO MEET OUR NATION’S FUTURE BIOMEDICAL RESEARCH WORKFORCE NEEDS. THE BRC PROGRAM ALSO ADHERES TO BEST PRACTICES FOR DEVELOPMENT OF YOUNG SCIENTISTS, CREATING AN IREC THAT FACILITATES THE DEVELOPMENT OF PARTICIPANT SELF-IMAGE AS A SCIENTIST, ENHANCES PERSISTENCE, AND PREPARES STUDENTS FOR BIOMEDICAL CAREERS.

VIRTUAL ZOOARCHAEOLOGY OF THE ARCTIC PROJECT (VZAP): PHASE II

TRAUMATIC BRAIN INJURY STATE PARTNERSHIP PROGRAM

REHABILITATION LONG- TERM TRAINING PROGRAM- CLINICAL REHABILITATION COUNSELING

TAS::97 0400::TAS BATTERY RECHARGING DEVICE USING ALPHA-ELECTRIC POWER SOURCE

FORECASTING RANGELAND CONDITION WITH GIS IN SOUTHEASTERN IDAHO.

TRIO - STUDENT SUPPORT SERVICES - STUDENT SUPPORT SERVICES PROGRAM

UPWARD BOUND MATH & SCIENCE

AFFORDABLE CARE ACT: PRIMARY CARE RESIDENCY EXPANSION

EPSCOR GRADUATE FELLOWSHIP PROGRAM (EGFP): IDAHO STUDENT EXCELLENCE IN EDUCATION AND RESEARCH (I-SEER) -THE NATIONAL SCIENCE FOUNDATION (NSF) EPSCOR GRADUATE FELLOWSHIP PROGRAM (EGFP) SUPPORTS EGFP DESIGNATED INSTITUTIONS AND PROGRAMS IN EPSCOR JURISDICTIONS BY PROVIDING FUNDING FOR GRADUATE FELLOWSHIPS FOR NEW OR CONTINUING EGFP-ELIGIBLE APPLICANTS. EGFP SUPPORTS A TOTAL OF THREE YEARS OF STIPEND AND ASSOCIATED COST-OF-EDUCATION (COE) ALLOWANCE FOR EACH NSF EPSCOR GRADUATE FELLOW. THIS AWARD AT IDAHO STATE UNIVERSITY (ISU) WILL SUPPORT SIX EPSCOR GRADUATE FELLOWS WITH FUNDING FROM NSF EGFP. THIS SUPPORT IS ALIGNED WITH GOALS AND PROGRAMS WITHIN THE NSF DIRECTORATE FOR BIOLOGICAL SCIENCES (BIO), NSF DIRECTORATE FOR GEOSCIENCES (GEO), AND THE NSF OFFICE OF INTEGRATIVE ACTIVITIES (OIA). THIS PROJECT, IDAHO STUDENT EXCELLENCE IN EDUCATION AND RESEARCH (I-SEER), WILL ADVANCE TALENT RECRUITMENT, DEVELOPMENT, AND RETENTION OF RESEARCHERS IN IDAHO AND THUS EXPAND REGIONAL EXCELLENCE IN STEM RESEARCH, STRENGTHENING ISU?S RESEARCH CAPACITY AND COMPETITIVENESS. INTEGRATION BETWEEN FELLOWS IN THE DEPARTMENT OF BIOLOGICAL SCIENCES, DEPARTMENT OF GEOSCIENCES, AND IDAHO'S EPSCOR RESEARCH INFRASTRUCTURE IMPROVEMENT I-CREWS PROJECT WILL PROMOTE INTERDISCIPLINARY RESEARCH AND BUILD CONNECTIONS AMONG MEMBERS OF PARTICIPATING DEPARTMENTS. THIS WILL POSITION THE UNIVERSITY TO BE A HUB THAT ADVANCES SCIENTIFIC KNOWLEDGE AND ADDRESSES REAL-WORLD ISSUES. FELLOWS WILL PURSUE GRADUATE DEGREES WITHIN THE BIOLOGICAL SCIENCES AND GEOSCIENCES DEPARTMENTS OR IN THE INTERDISCIPLINARY PROGRAMS ALIGNED WITH I-CREWS, INCLUDING CIVIL AND ENVIRONMENTAL ENGINEERING, COMPUTER SCIENCE, AND ANTHROPOLOGY. THE OVERARCHING GOAL IS TO DEVELOP A NEW GENERATION OF RESEARCHERS EQUIPPED TO SOLVE PRESSING SCIENTIFIC AND SOCIAL CHALLENGES. FELLOWS WILL ENGAGE IN CUTTING-EDGE RESEARCH USING METHODOLOGIES SUCH AS ARTIFICIAL INTELLIGENCE/MACHINE LEARNING, GEOSPATIAL ANALYSIS, FIELD-BASED DATA COLLECTION, LABORATORY INVESTIGATIONS, AND EXPLORING SOCIETAL TOPICS IN IDAHO COMMUNITIES. THE PROJECT WILL TRAIN SIX EGFP FELLOWS TO ANSWER CUTTING-EDGE RESEARCH QUESTIONS. ALL PROJECTS WILL ADDRESS COMPLEX, CRITICAL RESEARCH PROBLEMS AND TRAIN NEW SCIENTISTS AND ENGINEERS TO BE FUTURE LEADERS. SYNERGIES AMONG PARTICIPANTS WILL OCCUR THROUGH CROSS-CUTTING WORKSHOPS FOR PROFESSIONAL DEVELOPMENT. THIS PROJECT WILL ENHANCE ISU?S ABILITY TO RECRUIT AND TRAIN TALENTED GRADUATE STUDENTS AND EXPAND REGIONAL CAPACITY FOR STEM RESEARCH AND WORKFORCE DEVELOPMENT. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

RESIDENCY TRAINING IN PRIMARY CARE

PRIMARY CARE TRAINING AND ENHANCEMENT

A PROGRAM TO STUDY HADRONIC MATTER USING ELECTROMAGNETIC PROBES AT JEFFERSON LAB

SUD DNP/IPE EDUCATION - EDUCATING STUDENTS EARLY IN THEIR PROFESSIONAL COURSEWORK WILL INCREASE CONFIDENCE AND DECREASE STIGMA ASSOCIATED WITH TREATING PATIENTS WITH SUBSTANCE USE DISORDER (SUD). AN INTERDISCIPLINARY COHORT OF DOCTOR OF NURSING PRACTICE (DNP) (NURSE PRACTITIONER), PUBLIC HEALTH, AND COUNSELING STUDENTS WILL OBSERVE AND ENGAGE WITH SUD COMMUNITY EXPERTS TO LEARN FOUNDATIONAL BEST PRACTICE PROTOCOLS AND METHODS FOR SUD ASSESSMENT AND TREATMENT.  INTERVENTIONS INCLUDE IMPLEMENTATION OF THE SAMHSA 12 SUD MODULES, INTERDISCIPLINARY WORK AMONG THE HEALTHCARE STUDENTS, SYNCHRONOUS AND ASYNCHRONOUS WORK WITH OUR STUDENTS, COMMUNITY PARTNERS AND SUBJECT MATTER EXPERTS. FURTHER INTERVENTIONS INCLUDE CREATION OF A COMMUNITY ADVISORY COMMITTEE FOR ONGOING AND REAL TIME FEEDBACK TO ALLOW FOR APPROPRIATE CONTENT AND ACTIVITY ADJUSTMENT. EQUALLY IMPORTANT WILL BE IMPLEMENTATION OF DIRECT CLINICAL OBSERVATION TIME FOR OUR STUDENTS WITHIN THE COMMUNITY ORGANIZATIONS, ESPECIALLY THOSE THAT TREAT RURAL AND CULTURALLY DIVERSE POPULATIONS, ALLOWING FOR DIRECT LEARNING OF CURRICULAR CONTENT. SPECIFICALLY, OUR GOALS INCLUDE: ·       TRAINING STUDENTS EARLY IN THEIR ACADEMIC CAREERS O   PROVIDE EVIDENCE-BASED SUBSTANCE USE PREVENTION TRAINING O   DEMONSTRATE INCREASED CONFIDENCE LEVELS (ASSESS, DIAGNOSE, TREAT) ·       TEACH STUDENTS THAT SUD IS LIKE ANY CHRONIC DISEASE, THEREBY REDUCING STIGMA/DISCRIMINATION O   TEACH MOTIVATIONAL INTERVIEWING O   COMPLETE 3 INTERDISCIPLINARY ACTIVITIES AND CLINICAL OBSERVATION ·       INCREASE ACCESS TO SUD SCREENING, ASSESSMENT, AND SERVICES O   PROVIDE SUD ASSESSMENT AND TREATMENT CE/CME OPPORTUNITIES O   ESTABLISH A SUSTAINABILITY PLAN SO THAT THE SUD CURRICULUM BECOMES PERMANENT O   RECRUIT ADDITIONAL COMMUNITY CLINIC SITES IT IS EXPECTED THAT 106 STUDENTS WILL COMPLETE THE CURRICULUM IN YEAR 1 WITH 52 STUDENTS IN SUBSEQUENT YEARS FOR A TOTAL OF 210 STUDENTS OVER THE 3-YEAR PROJECT TIMELINE. THE NUMBER OF STUDENTS MAY INCREASE DUE TO ESTABLISHING PARTNERSHIPS WITH THE IDAHO COLLEGE OF OSTEOPATHIC MEDICINE, IDAHO STATE UNIVERSITY FAMILY MEDICINE RESIDENCY AND THE ADDITION OF CERTIFIED REGISTERED NURSE ANESTHESIA STUDENTS BEGINNING IN YEAR 2. TRAINED HEALTH PROFESSIONALS WILL HAVE A PROFOUND IMPACT ON SUD TREATMENT IN IDAHO AND THE UNITED STATES.

PROBING THE WEAK AND STRONG NATURE OF THE NUCLEON

NEW; EXPERIMENTAL STUDIES OF THE TRANSPORT PARAMETERS OF WARM DENSE MATTER; PI- KATHERINE CHANDLER

TRIO - TALENT SEARCH - TALENT SEARCH PROGRAM

CAREER: MECHANISMS REGULATING PHENOTYPIC PLASTICITY IN A HIGHLY SOCIAL HERMAPHRODITIC FISH -THIS WORK WILL ADVANCE NEW KNOWLEDGE OF HOW THE ENDOCRINE SYSTEM OF AN ORGANISM CONVERTS SIGNALS FROM THE EXTERNAL ENVIRONMENT TO ALTER TRAITS THAT ARE EXPRESSED ? A PHENOMENON KNOWN AS PHENOTYPIC PLASTICITY. THIS WILL BE ACCOMPLISHED THROUGH STUDYING A REMARKABLE NATURAL SYSTEM, A HIGHLY SOCIAL MARINE FISH, THE BLUEBANDED GOBY, THAT IS SEX ROLE REVERSED AND CAPABLE OF NATURAL SEX CHANGE AS AN ADULT. IN RESPONSE TO STATUS INSTABILITY IN THEIR SOCIAL GROUP, THESE FISH IMMEDIATELY DISPLAY BEHAVIORAL CHANGES AND OVER A FEW DAYS, A COMPLETE TRANSFORMATION OF THEIR REPRODUCTIVE ORGANS OCCURS. MULTIPLE BIOCHEMICAL PATHWAYS THAT ACTIVATE AND/OR DEACTIVATE STEROID HORMONES CAN RAPIDLY TURN ON TO MODULATE GENE EXPRESSION SO THAT CELLS AND ENTIRE TISSUES CAN CHANGE FUTURE FUNCTION. BY COMBINING TRADITIONAL APPROACHES AND TECHNOLOGICAL ADVANCES IN DISCIPLINES SUCH AS ANALYTICAL CHEMISTRY, BIO-ENGINEERING DESIGN, AND MOLECULAR BIOLOGY, THIS PROJECT WILL PROVIDE A COMPREHENSIVE UNDERSTANDING OF HOW STEROID HORMONE SIGNALING CAN REGULATE THESE COMPLEX CHANGES. THIS PROPOSAL SPECIFICALLY MERGES ACADEMIC TRAINEES FROM THE HIGH SCHOOL TO POSTDOCTORAL LEVEL TO CREATE INCLUSIVE LEARNING EXCHANGES. THROUGH ENROLLING IN A MULTI-YEAR COURSE, STUDENTS WILL WORK TOWARD MENTORED RESEARCH AND EDUCATIONAL GOALS WHERE THEY WILL BE ENCOURAGED TO BECOME ?KNOWLEDGE PRODUCERS? RATHER THAN ?CONSUMERS?, BUILDING A STRONG FOUNDATION FOR FUTURE SCIENTIFIC PURSUIT. IN ADDITION TO BUILDING SCIENTIFIC LITERACY IN THE GENERAL POPULATION AND RURAL COMMUNITIES, THIS PROJECT WILL DIRECTLY REMOVE BARRIERS FOR EXPOSURE TO SCIENCE FOR NATIVE AMERICAN YOUTH THROUGH EDUCATION ENRICHMENT MODULES. THE PHENOME, A SET OF ALL OBSERVABLE TRAITS EXPRESSED BY A CELL, TISSUE, ORGAN, ORGANISM, OR SPECIES, IS OFTEN TIGHTLY COUPLED VIA STRONG SELECTION WITH CHANGES IN THE PHYSICAL AND/OR SOCIAL ENVIRONMENT. THIS PROJECT INVESTIGATES MECHANISMS BY WHICH ENDOCRINE-NETWORK MOLECULES TRANSDUCE DYNAMIC SIGNALS IN THE SOCIAL ENVIRONMENT TO REGULATE BOTH RAPID AND LONG-TERM PHENOTYPIC RESPONSES DURING COMPLEX LIFE HISTORY TRANSITIONS. LYTHRYPNUS DALLI ARE A BI-DIRECTIONALLY HERMAPHRODITIC FISH SPECIES THAT HAVE ENVIRONMENTAL SEX DETERMINATION. STABLE SOCIAL GROUPS COMPRISE OF HAREMS WITH A SEX ROLE REVERSED MALE AT THE TOP OF THE HIERARCHY THAT PROVIDES PATERNAL CARE THROUGH INTENSE FANNING AND RUBBING OF EGGS. IN RESPONSE TO SOCIAL INSTABILITY, THE MOST DOMINANT FEMALE EXHIBITS HEIGHTENED AGGRESSION AND TERRITORIALITY, INITIATES PARENTING, AND CHANGES GONADAL MORPHOLOGY. EACH OF THE THREE AIMS OF THE PROJECT WILL ADDRESS A DIFFERENT LEVEL OF BIOLOGICAL ORGANIZATION THAT CONVERGES TECHNICAL AND CONCEPTUAL KNOWLEDGE TO STUDY THE INITIATION AND MAINTENANCE OF PHENOTYPES IN STABLE AND SEX CHANGING FISH: 1) DISCERN POST-TRANSLATIONAL MECHANISMS BY WHICH STEROIDOGENIC ENZYMES REGULATE SEX STEROID SYNTHESIS, 2) DETERMINE THE STEROID SIGNALING MECHANISMS THAT REGULATE FIN KINEMATICS DURING PARENTING, AND 3) DETERMINE THE SPATIO-TEMPORAL PATTERNS OF GENE REGULATORY NETWORKS. THE THIRD AIM WILL BE ACCOMPLISHED THROUGH A VERTICALLY INTEGRATED PROJECT COURSE WHEREIN UNDERGRADUATE STUDENTS WILL WORK IN SMALL GROUPS UNDER PEER-BASED MENTORSHIP TO DISCOVER THE ANATOMICAL DISTRIBUTION OF ENDOCRINE AND DEVELOPMENTAL GENES. ACCESS TO SCIENCE LITERACY WILL BE ENHANCED FOR RURAL POPULATIONS AND TRIBAL YOUTH THROUGH INNOVATIVE EDUCATIONAL MODULES THAT ADDRESS SPECIFIC CULTURAL NEEDS OF THE COMMUNITY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

NEW; THE DEVELOPMENT OF A POSITRON SOURCE FOR JLAB AT THE IAC; TONY FOREST

IDAHO STATE UNIVERSITY TRIO MCNAIR POSTBACCALAUREATE PROJECT

PROBING THE WEAK AND STRONG NATURE OF THE NUCLEON

DEVELOPMENT AND IMPLEMENTATION OF A PERSON-CENTERED HOSPITAL DISCHARGE PLANNING MODEL

ISU - TRIO EOC EASTERN

PROVIDING OPPORTUNITIES FOR WOMEN IN ENERGY RELATED (POWER) CAREERS

COLLABORATIVE RESEARCH: APPARATUS FOR NORMALIZATION AND SYSTEMATIC CONTROL OF THE MOLLER EXPERIMENT

DLT GRANTS - SUBSTANCE USE DISORDER - MEDICAL

NON-INVASIVE IDENTIFICATION & QUANTIFICATION OF ACTINIDE ELEMENTS IN LIQUID SAMPLES WITH INTENSE, TUNABLE, QUASI-MONOCHROMATIC & HIGHLY POLARIZED X-R

TWO NEUTRON CORRELATIONS IN PHOTOFISSION

MRI: ACQUISITION OF A LASER ABLATION - INDUCTIVELY COUPLED PLASMA - TRIPLE QUADRUPOLE - MASS SPECTROMETER (LA-ICP-QQQ-MS) SYSTEM FOR RESEARCH AND EDUCATION -THIS MAJOR RESEARCH INSTRUMENT AWARD SUPPORTS THE ACQUISITION OF AN AGILENT 8900 TRIPLE QUADRUPOLE ? INDUCTIVELY COUPLED PLASMA ? MASS SPECTROMETER (ICP-QQQ) COUPLED WITH THE COHERENT EXCISTAR XS EXCIMER LASER 193NM (LA) WITH LARGE OBJECT CHAMBER (LOC). THIS LOC-LA-ICP-QQQ NEXT-GENERATION RESEARCH INSTRUMENT WILL OPEN NEW FRONTIERS OF RESEARCH IN ARCHAEOLOGY, BIOLOGICAL SCIENCES, ENVIRONMENTAL SCIENCES, FORENSIC ANTHROPOLOGY, AND GEOSCIENCES. THIS PROJECT BENEFITS AN INTERNATIONAL GROUP OF 28 RESEARCHERS AND 14 COOPERATING INSTITUTIONS IN MULTIDISCIPLINARY GROUPS TO CONDUCT UNIQUE MATERIALS ANALYSIS AND ENABLE DIVERSE RESEARCH AT IDAHO STATE UNIVERSITY (ISU). THE INSTRUMENT WILL ALLOW CHEMICAL ANALYSIS OF ELEMENTS RANGING FROM 2?275 ATOMIC MASS UNIT. THIS INSTRUMENT WILL SERVE AS A RESEARCH AND TEACHING SYSTEM FOR ALL FACULTY, STUDENTS, RESEARCHERS, AND STAFF AT ISU. THIS INSTRUMENT WILL BE OPERATED AND CARED FOR BY THE CENTER FOR ARCHAEOLOGY, MATERIALS, AND SPECTROSCOPY IDAHO AND THE DEPARTMENT OF ANTHROPOLOGY IN THE COLLEGE OF ARTS AND LETTERS. THE INSTRUMENT WILL BE OPEN TO ALL RESEARCHERS ACROSS CAMPUS FOR GRANT FUNDED AND STUDENT RESEARCH PROJECTS. THIS SHARED INSTRUMENT WILL SERVE TO INCREASE FACULTY AND STUDENT SCHOLARSHIP, ATTRACT OUTSIDE RESEARCHERS, AND PROMOTE COLLABORATION. IT WILL ATTRACT AND RETAIN DIVERSE AND EXCEPTIONAL FACULTY AND STUDENTS, ENHANCE TEACHING AND LEARNING, AND FOSTER COMMUNITY SUPPORT. THE AVAILABILITY OF THIS SHARED INSTRUMENT GIVES THE ISU COMMUNITY THE OPPORTUNITY TO EXPLORE RESEARCH QUESTIONS THAT ARE NOT CURRENTLY POSSIBLE IN THE REGION. THIS IS ESPECIALLY TRUE FOR THE SUBSTANTIAL PROPORTION OF FEMALE, RURAL, INDIGENOUS, HISPANIC, AND LOW-INCOME STUDENTS AT ISU THAT OFTEN LOOK FOR EMPLOYMENT OUTSIDE OF ACADEMIA. THE LA-ICP-QQQ INSTRUMENT WILL BE USED TO RECRUIT MINORITY STUDENTS TO OUR GRADUATE PROGRAMS WHO CAN CONDUCT ORIGINAL RESEARCH UNDER MENTORSHIP OF THE CO-PI GROUP. WE WILL TRAIN AND ENGAGE STUDENTS IN UNDERSTANDING HOW THEY CAN APPLY SOPHISTICATED TECHNIQUES TO ANSWER CHALLENGING QUESTIONS ABOUT THE PAST AND TODAY IN BOTH THE NATURAL AND SOCIAL SCIENCES, AS WELL AS TO HELP PLAN FOR IMPROVED FUTURES IN OUR REGION. THE ACQUISITION OF THIS INSTRUMENT IS A SIGNIFICANT IMPROVEMENT IN THE ANALYTICAL CAPABILITIES OF ISU. THE EXCIMER LASER IS UNPARALLELED IN ITS CAPABILITY WITH HIGH-PRECISION, NON-DESTRUCTIVE AND RAPID ANALYSIS, REDUCED CONTAMINATION, AND DEPTH PROFILING. ALL OF THIS WHEN COUPLED WITH THE LOC ALLOWS FOR THE MOST ACCURATE ANALYSIS FOR CHALLENGING SAMPLES ACROSS DISCIPLINES. THE AGILENT 8900 IS A MULTI-TOOL MASS SPECTROMETER ALLOWS THE RESEARCH GROUPS TO CONDUCT AN ARRAY OF ANALYSES FOR LIQUIDS, SOLIDS, AND GASES. IT INTRODUCES ANALYTICAL CAPABILITIES SUCH AS LOW-LEVEL DETERMINATION OF PREVIOUSLY DIFFICULT ELEMENTS, SEPARATION OF DIRECT ISOBARIC OVERLAPS, AND FAST, TRACE ANALYSIS OF EMERGING NANO-SCALE MATERIALS TO EXTEND THE APPLICATION OF ICP-MS INTO NEW FRONTIERS OF ANALYSIS. SEVERAL EXAMPLES OF THESE PROJECTS ARE: INVESTIGATION OF NUMEROUS HUMAN BEHAVIORS INCLUDING TECHNOLOGICAL DEVELOPMENT, DECISION MAKING, AND MOBILITY WORLDWIDE THROUGH THE TRACING OF STONE TOOLS TO THEIR GEOLOGIC SOURCES; CONDUCT NUMEROUS GEOCHRONOLOGY ANALYSES, DETERMINE U-PB CRYSTALLIZATION/COOLING AGES OF ROCKS, LU- HF DATA, ASSESS PROFILES OF SOIL CHEMISTRY AT ARCHAEOLOGICAL SITES, REVEAL CHANGES IN VOLCANIC SEDIMENT COMPOSITION THROUGH TIME, AND FINGERPRINT TRACE ELEMENT GEOCHEMICAL SIGNATURES IN VARIOUS ROCKS AND MINERALS IN RIVER SYSTEMS; HELP SOLVE NUMEROUS FORENSICS MISSING PERSONS CASES, INCLUDING THOSE OF UNIDENTIFIED MIGRANTS, BY APPLYING NEW TRACE ELEMENT ANALYTICAL TECHNIQUES; EXAMINE HOW INTERACTIONS AMONG BIOLOGICAL, GEOLOGICAL, AND CHEMICAL SYSTEMS IMPACT HUMAN HEALTH VIA GROUNDWATER CONSUMPTION AND CONTAMINATION; AND INVESTIGATE THE PIVOTAL ROLE THAT HEAVY METALS PLAY IN THE VIRULENCE OF BACTERIA, PARTICULARLY AMONG INVERTEBRATE HOSTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

CAREER: ACTIVE LEARNING ACROSS INTERFACES: CONTROLS ON FLOW INTERMITTENCY AND WATER AGE IN TEMPORARY STREAMS

DLT GRANTS - SUBSTANCE USE DISORDER - MEDICAL

NUCLEAR ENERGY UNIVERSITY PROGRAMS - NUCLEAR ENERGY UNIVERSITY PROGRAMS CONSOLIDATED INNOVATIVE NUCLEAR RESEARCH - IDAHO STATE UNIVERSITY

CONSTRUCTION FOR INVESTIGATIONS OF ISOTOPE PRODUCTION WITH PHOTO-NUCLEAR REACTIONS

CAREER: SUPPORTING UNDERGRADUATE STUDENTS' AGENCY TO SHAPE SCIENCE PRACTICES FROM FIELD STATIONS TO CLASSROOMS -SCIENCE MOVES FORWARD THROUGH THE CONSTRUCTION AND CRITIQUE OF KNOWLEDGE CLAIMS ? TWO CENTRAL AND INTERRELATED PRACTICES THAT SCIENTISTS USE TO DO THEIR WORK. STUDENT PARTICIPATION IN THESE SCIENCE PRACTICES IS AN ESSENTIAL, BUT LARGELY ABSENT, PART OF LEARNING IN COLLEGE SCIENCE COURSES. THERE IS SIGNIFICANT MOMENTUM BEHIND CALLS TO ENGAGE STUDENTS IN THE PRACTICES THAT SCIENTISTS USE TO GENERATE, CRITIQUE, AND REVISE KNOWLEDGE THROUGH UNDERGRADUATE RESEARCH EXPERIENCES. HOWEVER, THERE IS A CRITICAL RESEARCH NEED TO EXAMINE THE ROLES STUDENTS ARE PERMITTED TO TAKE UP AS DOERS OF SCIENCE IN RESEARCH EXPERIENCES: AS TECHNICIANS WHO FOLLOW INSTRUCTIONS OR AS ?EPISTEMIC AGENTS? WHO SHAPE THE CONSTRUCTION AND CRITIQUE OF KNOWLEDGE CLAIMS. THIS PROJECT SEEKS TO SERVE THE NATIONAL INTEREST BY DEVELOPING RESEARCH-BASED UNDERSTANDINGS ON HOW TO FOSTER UNDERGRADUATE STUDENTS? AGENCY TO SHAPE SCIENCE PRACTICES AND HOW SUCH PARTICIPATION SUPPORTS SCIENCE LEARNING. THE FINDINGS FROM THIS PROJECT WILL IMPROVE UNDERGRADUATE SCIENCE EDUCATION BY INFORMING THE DESIGN OF UNDERGRADUATE RESEARCH EXPERIENCES THAT EMPOWER STUDENTS? AGENCY TO CONSTRUCT AND CRITIQUE KNOWLEDGE, PREPARING THEM TO BE LEADERS AND INNOVATORS FOR THE ADVANCEMENT OF SCIENCE. THIS PROJECT, HOUSED AT IDAHO STATE UNIVERSITY, WILL EXAMINE HOW STUDENTS CONSTRUCT AND CRITIQUE KNOWLEDGE CLAIMS DURING COURSE-BASED UNDERGRADUATE RESEARCH EXPERIENCES (CURES) AND SUMMER RESEARCH EXPERIENCES AT A BIOLOGICAL FIELD STATION. THIS PROJECT WILL DRAW ON SOCIOCULTURAL PERSPECTIVES TO FRAME SCIENCE LEARNING AS INVOLVING MULTIPLE INTEGRATED COMPONENTS: MAKING MEANING OF SCIENCE EXPERIENCES AND PHENOMENA, PARTICIPATING IN SCIENCE PRACTICES, SHIFTING OR SOLIDIFYING IDENTITIES, AND NAVIGATING BELONGING IN SCIENCE COMMUNITIES. THIS RESEARCH PROJECT WILL EXPLORE HOW PARTICIPATING IN THE SCIENCE PRACTICES OF CONSTRUCTION AND CRITIQUE CREATES LEARNING OPPORTUNITIES FOR STUDENTS? BECOMING AND BELONGING IN THE SCIENCE COMMUNITIES OF THEIR RESEARCH EXPERIENCES. THE SPECIFIC OBJECTIVES ARE TO (1) STUDY AND FOSTER UNDERGRADUATE STUDENTS? EPISTEMIC AGENCY, (2) STUDY AND SUPPORT EDUCATOR MOVES AND TOOLS TO FOSTER EPISTEMIC AGENCY, AND (3) STUDY HOW EPISTEMIC AGENCY RELATES TO SOCIOCULTURAL COMPONENTS OF SCIENCE LEARNING. TO ACCOMPLISH THESE OBJECTIVES ACROSS TWO CONTEXTS OF RESEARCH EXPERIENCES (CURES AND SUMMER RESEARCH AT THE ROCKY MOUNTAIN BIOLOGICAL LABORATORY FIELD STATION), THE PROJECT TEAM WILL DRAW ON NATURALISTIC CASE STUDY METHODOLOGY IN CONJUNCTION WITH DESIGN-BASED RESEARCH METHODOLOGY. DATA COLLECTION STRATEGIES WILL INCLUDE DIRECT OBSERVATIONS AND FIELDNOTES OF STUDENTS PARTICIPATING IN RESEARCH EXPERIENCES, SURVEYS, AND SEMI-STRUCTURED INTERVIEWS. THESE DATA WILL BE ANALYZED USING QUALITATIVE METHODS, INCLUDING DISCOURSE ANALYSIS, CRITICAL EVENT ANALYSIS, CONTENT ANALYSIS, AND CONJECTURE MAPPING. BASED ON THE RESEARCH FINDINGS, THE PROJECT TEAM WILL DESIGN AND IMPLEMENT A PROFESSIONAL DEVELOPMENT PROGRAM FOR FACULTY TO LEARN HOW TO FOSTER STUDENTS? EPISTEMIC AGENCY THROUGH CURES. THE SUCCESS OF THE PROJECT WILL BE ASSESSED BY THE PRODUCTION OF: (1) THE FACULTY PROFESSIONAL DEVELOPMENT PROGRAM, (2) LOCAL THEORY EXPLAINING HOW STUDENTS LEARN SCIENCE THROUGH PARTICIPATION IN SCIENCE PRACTICES, AND (3) RICH EMPIRICAL DESCRIPTIONS OF STUDENTS SHAPING SCIENCE PRACTICES AT FIELD STATIONS AND IN CURES. AN EXPERT ADVISORY BOARD WILL PROVIDE ANNUAL FEEDBACK ON THE PROJECT'S PROGRESS, AS WELL AS FORMATIVE AND SUMMATIVE EVALUATION. THE RESULTS OF THE PROJECT WILL BE DISSEMINATED THROUGH PUBLICATIONS IN PEER REVIEWED SCIENCE EDUCATION JOURNALS, PRESENTATIONS, AND WORKSHOPS AT SCIENCE AND SCIENCE EDUCATION CONFERENCES. THIS PROJECT WILL ADVANCE NEW UNDERSTANDINGS IN THE FIELD ABOUT (1) HOW STUDENTS TAKE UP EPISTEMIC AGENCY TO SHAPE SCIENCE; (2) HOW EDUCATORS OPEN AVENUES FOR STUDENTS? PARTICIPATION IN SCIENCE PRACTICES; AND (3) HOW SUCH PARTICIPATION IS INTERTWINED WITH DEVELOPING IDENTITIES AND SENSE OF BELONGING. ULTIMATELY, THIS PROJECT WILL IMPROVE UNDERGRADUATE SCIENCE EDUCATION BY SUPPORTING EDUCATORS TO ATTUNE TO DIVERSE REPERTOIRES OF PARTICIPATION IN SCIENCE AND TO VALUE, DESIGN FOR, AND RECOGNIZE STUDENTS? AGENCY TO SHAPE SCIENCE PRACTICES. THE FACULTY EARLY CAREER DEVELOPMENT (CAREER) PROGRAM IS A NATIONAL SCIENCE FOUNDATION (NSF)-WIDE ACTIVITY THAT SUPPORTS EARLY-CAREER FACULTY WHO HAVE THE POTENTIAL TO SERVE AS ACADEMIC ROLE MODELS IN RESEARCH AND EDUCATION. THIS CAREER PROJECT IS SUPPORTED BY NSF?S IMPROVING UNDERGRADUATE STEM EDUCATION (IUSE) PROGRAM. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

CHILDCARE ACCESS MEANS PARENTS IN SCHOOL - CHILD CARE

SCHOLARSHIPS FOR CHEMISTRY AND BIOCHEMISTRY

ENERGY SYSTEMS SCHOLARS

MECHANISMS OF RESPIRATORY-RELATED RHYTHMIC MOTOR ACTIVITY AND PLASTICITY IN THE AVIAN BRAIN STEM

COLLABORATIVE RESEARCH: SCALES AND DRIVERS OF VARIABILITY IN DISSOLVED ORGANIC CARBON ACROSS DIVERSE URBAN WATERSHEDS

IHEAR- RELATED SERVICE PROVIDERS

PREPARING PERSONNEL TO SERVE INFANTS, TODDLERS, AND PRESCHOOL-AGE CHILDREN

MECHANISTIC AND KINETIC ANALYSIS OF POLYMER DECONSTRUCTION AND MODIFICATION BY IRRADIATION FOR POLYMER UPCYCLING

DIMENSIONS: COLLABORATIVE RESEARCH: RESEARCH ON AIRBORNE ICE-NUCLEATING SPECIES (RAINS)

EPIGENETIC INFLUENCES SUPPORTING DEVELOPMENTAL CHANGE IN SPINAL CORD PLASTICITY AND MOTOR BEHAVIOR

IN PARTNERSHIP WITH THE DEPARTMENT OF INTERIOR'S BUREAU OF LAND MANAGEMENT (BLM), WE PROPOSE TO BUILD AND EVALUATE THE PROTOTYPE RECOVER DECISION SUP

IDAHO STATE UNIVERSITY FELLOWSHIP AND SCHOLARSHIP SUPPORT

SCHOLARSHIPS IN CHEMISTRY AND BIOCHEMISTRY IN IDAHO

DISTANCE LEARNING GRANT

ADAPTATION OF THE ISIS INDUCTION-CELL DRIVER TO A LOW-IMPEDANCE PLASMA RADIATION SOURCE DRIVER-THRUST AREA 1

THE FINESSE (FIELD INVESTIGATIONS TO ENABLE SOLAR SYSTEM SCIENCE AND EXPLORATION) TEAM PROPOSES A SCIENCE AND EXPLORATION FIELD-BASED RESEARCH PROGRA

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY OF IRON RESPIRING BACTERIA FROM ACIDIC AND NEUTRAL PH ENVIRONMENTS

BRC-BIO: DISPERSAL OF DEEP BIOSPHERE EXTREMOPHILES IN SEAFLOOR SEDIMENTS -MARINE SEDIMENTS BELOW SEAFLOOR GLOBALLY CONSTITUTE AN INHOSPITABLE HABITAT CHARACTERIZED BY PERMANENT DARKNESS AND LIMITED SUPPLY OF ENERGY. NEVERTHELESS, THIS SEDIMENTARY REALM HOSTS A LARGE MICROBIAL BIOMASS CONSISTING OF DIVERSE COMMUNITIES WITH DIVERSE METABOLIC CAPABILITY. HOW BIODIVERSITY IN THIS EXCLUSIVELY MICROBIAL HABITAT IS MAINTAINED, HOWEVER, REMAINS POORLY UNDERSTOOD. THIS PROJECT SEEKS TO ADVANCE THE UNDERSTANDING OF THE ECOLOGICAL AND EVOLUTIONARY IMPLICATIONS OF DISPERSAL, I.E., MOVEMENT OF ORGANISMS THROUGH SPACE AND TIME, AS A DRIVING FORCE OF COMMUNITY ASSEMBLY AND TURNOVER IN SUBSEAFLOOR SEDIMENTS. THE OVERARCHING OBJECTIVE OF THIS RESEARCH IS TO EVALUATE THE POTENTIAL OF SUBSURFACE FLUID DISCHARGES SUCH AS UPWARDLY MIGRATING HYDROCARBONS AT MARINE COLD SEEPS AND WARM HYDROTHERMAL FLUIDS EMANATING FROM SEAMOUNTS IN TRANSPORTING MICROORGANISMS FROM THE DEEP BIOSPHERE TO THE SEAFLOOR. IN ADDITION, THIS PROJECT WILL PROVIDE BOTH SHORT- AND LONG-TERM TRAINING FOR YOUNG RESEARCHERS ACROSS DIFFERENT CAREER STAGES AND THE REQUIRED INFRASTRUCTURE TO SUPPORT A NEW FACULTY MEMBER?S RESEARCH PROGRAM AT IDAHO STATE UNIVERSITY. LONG-TERM SUPPORT WILL BE PROVIDED TO TWO GRADUATE STUDENTS AND NINE UNDERGRADUATE SUMMER STUDENTS. FURTHERMORE, RESEARCH ACTIVITIES WILL BE INTEGRATED INTO TWO COURSE BASED UNDERGRADUATE RESEARCH EXPERIENCE (CURE) LAB COURSES AND A VERTICALLY INTEGRATED PROJECT (VIP) COURSE WHICH WILL PROVIDE HANDS-ON RESEARCH EXPERIENCE TO APPROXIMATELY 30 UPPER DIVISION UNDERGRADUATE STUDENTS ANNUALLY. THIS PROJECT IS JOINTLY FUNDED BY THE BUILDING RESEARCH CAPACITY IN BIOLOGY PROGRAM, THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR), AND THE BIOLOGICAL OCEANOGRAPHY PROGRAM. THIS PROJECT PROPOSES TO USE DORMANT ENDOSPORES OF THERMOPHILIC BACTERIA AS MODEL ORGANISMS TO STUDY THE SIGNIFICANCE OF MICROBIAL DISPERSAL IN SUSTAINING BIODIVERSITY IN THE DEEP BIOSPHERE. THESE BACTERIA ARE WIDESPREAD IN MARINE SEDIMENTS GLOBALLY AND ARE GENETICALLY SIMILAR TO BACTERIA INHABITING WARM, DEEPLY BURIED PETROLEUM RESERVOIRS, HYDROTHERMAL VENT CHIMNEYS AND CRUSTAL AQUIFERS. PREVIOUS RESEARCH FOCUSED ON COLD SEEPS IN THE GULF OF MEXICO HAS PROVIDED EVIDENCE THAT HYDROCARBON-RICH FLUID FLOW CAN SUPPLY VIABLE THERMOPHILIC SPORES FROM DEEP TO SHALLOW SEDIMENTARY HABITATS. THE PROPOSED RESEARCH WILL ADDRESS A CRITICAL NEED TO UNDERSTAND HOW LABORATORY INCUBATION CONDITIONS IMPACT THE DETECTION OF ENDOSPORE POPULATIONS IN COLD SEABED SEDIMENTS, EXPOSING NEW METABOLIC VARIATION. SEDIMENT HEATING AT MULTIPLE TEMPERATURES FOLLOWED BY MOLECULAR COMMUNITY SURVEILLANCE WILL BE EMPLOYED TO IDENTIFY NOVEL SUBSURFACE BACTERIA IN COLD SEEP SEDIMENTS FROM THE GULF OF MEXICO AND MONTEREY CANYON, AND CRUSTAL-FLUID-IMPACTED SEDIMENTS FROM THE JUAN DE FUCA RIDGE FLANK OFF THE COAST OF WASHINGTON, USA. A GENOME-CENTRIC METAGENOMIC APPROACH WILL SUBSEQUENTLY BE USED TO UNRAVEL METABOLIC TRAITS OF THESE ORGANISMS AS AN INDICATION OF SUBSURFACE PROVENANCE. THE RESULTS ARE EXPECTED TO DETERMINE WHETHER FLUID-MEDIATED DISPERSAL OF SUBSURFACE ORGANISMS IS LIMITED TO SPECIFIC SEAFLOOR FEATURES OR IF IT IS A MORE WIDESPREAD MECHANISM OF TRANSPORTING VIABLE MICROBIAL BIOMASS ACROSS THE DEEP BIOSPHERE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM FOR PARAPROFESSIONALS - IDAHO’S LACK OF MENTAL HEALTH PROFESSIONALS SEVERELY IMPACTS THE STATE WITH EVERY COUNTY DESIGNATED AS A SHORTAGE AREA. AS COMMUNITY LIAISONS, COMMUNITY HEALTH WORKERS (CHWS) ARE WELL-POSITIONED TO ALLEVIATE THIS GAP. IDAHO STATE UNIVERSITY’S CHW TRAINING ACADEMY PROPOSES THE IDAHO BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING (I-BHWET) PROGRAM TO IMPROVE AND EXPAND THE TRAINING OF CHWS AS PARAPROFESSIONALS WITHIN IDAHO’S BEHAVIORAL HEALTH WORKFORCE. FUNDING IS REQUESTED FOR I-BHWET LEVELS 1 (PRE-SERVICE) AND LEVEL 2 (IN-SERVICE) TO PROVIDE TRAINEE SUPPORT. OUR CHW REGISTERED APPRENTICESHIP PROGRAM WAS ESTABLISHED BY THE U.S. DEPARTMENT OF LABOR IN 2022. THROUGH INNOVATIVE CURRICULUM ENHANCEMENTS, EXPANDED EXPERIENTIAL TRAINING OPPORTUNITIES AND SUPPORT, AND STRATEGIC COMMUNITY PARTNERSHIPS, THIS PROJECT WILL EQUIP TRAINEES AT BOTH LEVELS WITH THE ESSENTIAL SKILLS TO DELIVER HIGH-QUALITY, EVIDENCE-BASED BEHAVIORAL HEALTH SERVICES AND COORDINATION AS PART OF A CARE TEAM. THE PROGRAM EMPHASIZES INTERDISCIPLINARY COLLABORATION, THE INTEGRATION OF BEHAVIORAL HEALTH INTO PRIMARY CARE AND COMMUNITY-BASED ORGANIZATIONS, AND THE DEVELOPMENT OF DIGITAL HEALTH LITERACY AND TELE-BEHAVIORAL HEALTH TECHNOLOGICAL SKILLS TO IMPROVE SERVICE ACCESSIBILITY ACROSS IDAHO. THROUGH EXPERIENTIAL TRAINING, OUR INITIATIVE WILL INCREASE THE NUMBER OF WELL-TRAINED CHWS WORKING IN BEHAVIORAL HEALTH SETTINGS, PARTICULARLY WITH CHILDREN, ADOLESCENTS, AND TRANSITIONAL-AGE YOUTH IN HIGH-NEED AND HIGH-DEMAND AREAS. THE I-BHWET PROGRAM REQUESTS FUNDING PRIORITY BASED ON PRIORITY 1: THE ROLE OF THE FAMILY AND THE LIVED EXPERIENCE OF THE CONSUMER AND FAMILY PARAPROFESSIONAL PARTNERSHIP, AND FUNDING PREFERENCE BASED ON OUR FULFILLMENT OF QUALIFICATION 1: HIGH RATE, QUALIFICATION 2: SIGNIFICANT INCREASE, AND QUALIFICATION 3: NEW PROGRAM CRITERION 1, 2, 3, 5, 6, AND 7.

TRAUMATIC BRAIN INJURY STATE IMPLEMENTATION PARTNERSHIP GRANT PROGRAM

INCORPORATION OF NOVEL NANOSTRUCTURED MATERIALS INTO SOLAR CELLS AND NANOELECTRONIC DEVICES

WOMEN'S PATHWAYS TO JAIL EVALUATION PROJECT

IDAHO STATE UNIVERSITY PULSED POWER DRIVER TO GENERATE AND MEASURE HED STATES MOD 0000 FULLY FUNDS BUDGET YEAR 1 OF THE GRANT IN THE AMOUNT OF $164,115

NRI-SMALL: COLLABORATIVE RESEARCH: A DESIGN METHODOLOGY FOR MULTI-FINGERED ROBOTIC HANDS WITH SECOND-ORDER KINEMATIC CONSTRAINTS

CDS&E: IMMERSIVE VIRTUAL REALITY FOR DISCOVERING HIDDEN CHEMICAL INFORMATION AND IMPROVING MULTIVARIATE MODELING AND PREDICATION -WITH SUPPORT FROM THE CHEMICAL MEASUREMENT AND IMAGING (CMI) PROGRAM IN THE CHEMISTRY DIVISION, AND PARTIAL CO-FUNDING FROM THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR) AND THE HUMAN-CENTERED COMPUTING PROGRAM, PROFESSOR JOHN KALIVAS AND HIS UNDERGRADUATE GROUP AT IDAHO STATE UNIVERSITY ARE DEVELOPING NEW VIRTUAL REALITY (VR) METHODS OF CHEMICAL DATA ANALYSIS. IN COLLABORATION WITH THE APPLIED VISUALIZATION LABORATORY AT THE IDAHO NATIONAL LABORATORY, THE KALIVAS GROUP IS COMPLEMENTING DATA VISUALIZATION VR PROCESSES WITH TACTILE AND AUDITORY ELEMENTS TO ENHANCE DATA ANALYSIS. BY INCLUDING ALL THREE HUMAN SENSES IN CONJUNCTION WITH THE HUMAN?S UNIQUE REASONING CAPABILITIES, IT SHOULD BE POSSIBLE TO OUTPERFORM THE COMPUTER IN COMPLEX DATA ANALYSIS SITUATIONS WHERE THE COMPUTER IS RESTRICTED TO NUMERICAL CONCLUSIONS. THERE ARE MANY DATA ANALYSIS SITUATIONS WHERE CRITICAL DECISIONS MUST BE MADE THAT ARE NOT ALWAYS OBVIOUS, SUCH AS DECIDING IF AN EARLY BIOPSY IS CANCEROUS OR NOT. IN ADDITION TO MEDICAL DIAGNOSTICS, THE INSIGHTS GAINED WILL BE USEFUL FOR A BROAD RANGE OF OTHER APPLICATIONS SUCH AS PROCESS ANALYTICAL TECHNOLOGIES AND THE AGRICULTURE INDUSTRY. EDUCATIONAL VERSIONS OF THE VR PROGRAMS ARE BEING DEVELOPED TO ALLOW BLIND AND DEAF STUDENTS TO LEARN AND EXPLORE DATA SCIENCE PROCESSES, BRINGING THESE STUDENTS TO THE FOREFRONT OF MACHINE LEARNING TECHNOLOGY. THIS PART OF THE WORK IS BEING DEVELOPED IN COLLABORATION WITH THE IDAHO EDUCATIONAL SERVICES FOR THE DEAF AND BLIND. THE PROJECT WILL PROVIDE RESEARCH OPPORTUNITIES FOR UNDERGRADUATES AND HIGH SCHOOL STUDENTS IN UNDERSERVED REGIONS OF IDAHO. IN THIS PROJECT, THE KALIVAS TEAM IS EXPLOITING THEIR RECENTLY DEVELOPED PHYSICOCHEMICAL RESPONSE INTEGRATED SPECTRAL MEASUREMENT (PRISM) APPROACH IN VR. A STRATEGIC FEATURE OF PRISM IS THAT IT IS COMPOSED OF HUNDREDS OF SAMPLE-WISE SIMILARITY MEASURES BASED ON AMPLIFYING HIDDEN-BUT-ESSENTIAL CHEMICAL (AND PHYSIOCHEMICAL IF PRESENT) PROPERTIES ENCODED WITHIN MEASURED SPECTRA SUCH AS INFRARED (IR), NEAR IR, RAMAN, ETC. EACH OF THESE SIMILARITY MEASURES CAN BE INCORPORATED AS AN OBJECT FEATURE IN THE VR SETTING TO FULLY CHARACTERIZE THE INHERENT CHEMICAL NATURE OF A SAMPLE. A KEY GOAL OF THIS EXPLORATORY PROJECT IS TO EFFECTIVELY CONVERT MULTIDIMENSIONAL CHEMICAL DATA TO VR THEREBY SIGNIFICANTLY ENHANCING THE CONNECTION BETWEEN DATA AND DISCOVERY. USING VR TO DEPICT DATA POINTS/SAMPLES VISUALLY, HAPTICALLY (TOUCHING INCLUDING TEXTURE TO DATA SHAPES), AND WITH SONIFICATION (SOUND FOR EACH DATA POINT), THE HUMAN USER WILL BE ABLE TO EXPLORE DATA IN-DEPTH TO UNCOVER HIDDEN PATTERNS AND CORRESPONDING CHEMICAL ATTRIBUTES. WITH SUCH A DETAILED DATA ANALYSIS PROCESS, IMPROVED CLASSIFICATION AND TARGET SAMPLE PREDICTIONS WITH BETTER EXPLANATIONS OR INTERPRETATIONS OF SAMPLE RELATIONSHIPS SHOULD BE POSSIBLE. ALL DEVELOPED ALGORITHMS WILL BE POSTED TO THE KALIVAS WEB SITE, ALLOWING FREE ACCESS TO POTENTIAL USERS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

TRAUMATIC BRAIN INJURY IMPLEMENTATION

BCAL MAPWINDOW VIRTUAL WATERSHEDS; TOWARDS VIRTUAL WATERSHEDS: INTEGRATED DATA MINING MAPPING AND MODELING USING STANDARDS BASED WEB SERVICES AND O

COLLABORATIVE RESEARCH: QUANTIFYING THE AMOUNT AND FUNCTIONAL SIGNIFICANCE OF LONG-TERM STORED-WATER IN TREES

IDAHO STATE UNIVERSITY (ISU) NEUP- INFRASTRUCTURE SUPPORT FOR RADIOANALYTICAL AND HEALTH PHYSICS LAB

COLLABORATIVE RESEARCH: REVERBERATING RESPONSES TO TROPHIC CASCADES ACROSS ECOSYSTEMS: FROM LAND TO STREAMS AND BACK AGAIN

CDS&E: REGULARIZATION ADAPTION PROCESSES FOR MULTIVARIATE CALIBRATION AND MAINTENANCE

TRAUMATIC BRAIN INJURY STATE PARTNERSHIP PROGRAM PARTNER

FACULTY DEVELOPMENT PROGRAM IN NUCLEAR ENGINEERING AT IDAHO STATE UNIVERSITY

GREATER SAGE-GROUSE ECOLOGY AND HABITAT MAPPING IN NEVADA: A PROPOSED STUDY TO COORDINATE WITH ONGOING RESEARCH IN EVALUATING GREATER SAGE-GROUSE POP

TELLER LIGHT PRODUCTION AND TRANSMISSION IN MIXED GASES AND ASSOCIATED RADIO FREQUENCY RADIATION

FORECASTING RANGLELAND CONDITION WITH GIS IN SOUTHEASTERN IDAHO

07PAHYBRID-K-EDGE/X-RAY FLUORESCENSE DENSITOMETRY WITH LASER-COMPTON SCATTERED X-RAYS

PRIMARY CARE TRAINING AND ENHANCEMENT -- RESIDENCY TRAINING IN STREET MEDICINE - IDAHO STATE UNIVERSITY’S FAMILY MEDICINE RESIDENCY (ISU FMR) PROPOSES THE IDAHO FRONTIERS OF STREET MEDICINE PROJECT (IFSMP) TO EXPAND THE TRAINING OF FAMILY MEDICINE PHYSICIANS IN DELIVERING HIGH-QUALITY, EVIDENCE-BASED CARE TO PEOPLE EXPERIENCING HOMELESSNESS. IDAHO HAS A GROWING POPULATION OF INDIVIDUALS FACING HOUSING INSTABILITY, YET ACCESS TO MEDICAL CARE IN NON-TRADITIONAL SETTINGS REMAINS LIMITED. ISU FMR WILL INTEGRATE STREET MEDICINE TRAINING INTO RESIDENCY EDUCATION, EQUIPPING FUTURE PHYSICIANS WITH THE SKILLS TO PROVIDE COMPREHENSIVE CARE TO VULNERABLE POPULATIONS IN UNSHELTERED ENVIRONMENTS. OBJECTIVES: THE GOAL OF IFSMP IS TO INCREASE THE NUMBER OF PRIMARY CARE PHYSICIANS TRAINED IN STREET MEDICINE WHO ARE PREPARED TO CARE FOR INDIVIDUALS EXPERIENCING HOMELESSNESS BY BRINGING HEALTHCARE DIRECTLY TO THEM. ISU FMR WILL ACHIEVE THIS BY: 1. DEVELOPING STRUCTURED CLINICAL ROTATIONS, DIDACTICS, AND INTERPROFESSIONAL TRAINING THAT INCLUDE BEHAVIORAL HEALTH, SUBSTANCE USE DISORDER TREATMENT, AND MEDICAL-LEGAL ADVOCACY. 2. ENHANCING RESIDENTS’ ABILITY TO NAVIGATE MEDICAL, BEHAVIORAL HEALTH, LEGAL, AND SOCIAL SYSTEMS TO IMPROVE PATIENT OUTCOMES. 3. EXPANDING INTERPROFESSIONAL COLLABORATION THROUGH PARTNERSHIPS WITH BEHAVIORAL HEALTH, PHARMACY, LEGAL AID, AND MOBILE OUTREACH TEAMS TO ADDRESS SOCIAL DETERMINANTS OF HEALTH. HHS CLINICAL PRIORITIES: BEHAVIORAL HEALTH, OPIOIDS / SUBSTANCE USE DISORDER, RURAL HEALTH, TELEHEALTH / TELEMEDICINE. METHODOLOGY: IFSMP WILL ESTABLISH FORMALIZED STREET MEDICINE ROTATIONS, BEGINNING WITH AN INTERN COMMUNITY MEDICINE MONTH AND PROGRESSING TO ADVANCED TRAINING IN UNSHELTERED CARE. RESIDENTS WILL WORK ALONGSIDE FACULTY, INTERPROFESSIONAL TEAMS, AND COMMUNITY OUTREACH ORGANIZATIONS TO DELIVER CARE IN SHELTERS, MOBILE CLINICS, AND ENCAMPMENTS. FACULTY DEVELOPMENT WILL FOCUS ON TRAUMA-INFORMED CARE, CRISIS DE-ESCALATION, AND RESOURCE NAVIGATION. FUNDING PREFERENCE: THE MEDICALLY UNDERSERVED COMMUNITY FUNDING PREFERENCE IS REQUESTED AND MET BASED ON QUALIFICATION 1: HIGH RATE. IN THE 22/23 AND 23/24 ACADEMIC YEARS, 87.5% OF ISU FMR GRADUATES WENT ON TO PRACTICE IN MEDICALLY UNDERSERVED COMMUNITIES. FUNDING PRIORITY: THE ISU DFM REQUESTS, AND QUALIFIES FOR, THE “TRAIN RESIDENTS IN RURAL AREAS” FUNDING PRIORITY. THE IFSMP WILL TRAIN RESIDENTS IN IDAHO COMMUNITIES DESIGNATED AS RURAL BY THE FEDERAL OFFICE OF RURAL HEALTH POLICY INCLUDING: AMERICAN FALLS, REXBURG, RUPERT, FORT HALL, COTTONWOOD, AND NUMEROUS RURAL ROTATION SITES THROUGHOUT THE STATE.

BE/CNH: COMPLEX ECOSYSTEM INTERACTIONS OVER MULTIPLE SPATIAL AND TEMPORAL SCALES: THE BIOCOMPLEXITY OF SANAK ISLAND

INVESTIGATION OF THE SERINE PROTEASE MASP1 AS A NOVEL REGULATOR OF BMP SIGNALING DURING EARLY EMBRYONIC DEVELOPMENT. - PROJECT SUMMARY DISRUPTION OF DEVELOPMENTAL PROCESSES, OFTEN DUE TO GENETIC MUTATION, CAN LEAD TO STRUCTURAL BIRTH DEFECTS THAT HAVE LIFE-LONG CONSEQUENCES FOR AFFECTED INDIVIDUALS AND THEIR FAMILIES. IDENTIFICATION OF PATIENT- SPECIFIC GENETIC CHANGES, FOLLOWED BY MECHANISTIC STUDIES, CAN INCREASE OUR UNDERSTANDING OF HOW DEVELOPMENTAL PERTURBATIONS LEAD TO DEFECTS AND OFFER INSIGHT INTO POTENTIAL FUTURE CLINICAL INTERVENTIONS. OUR LONG-TERM GOAL IS TO IDENTIFY MOLECULAR AND CELLULAR FUNCTIONS OF PATIENT-IDENTIFIED, DISORDER-ASSOCIATED GENES WITH UNKNOWN ROLES IN EMBRYONIC DEVELOPMENT. HERE, WE FOCUS ON ONE SUCH GENE, MANNOSE- BINDING LECTIN-ASSOCIATED SERINE PROTEASE 1 (MASP1), MUTATIONS OF WHICH ARE ASSOCIATED WITH THE DEVELOPMENTAL DISORDER 3MC SYNDROME. OUR OBJECTIVE FOR THIS PROPOSAL IS TO IDENTIFY THE UNDERLYING MOLECULAR FUNCTIONS OF MASP1 IN DEVELOPMENT. WE HAVE FOUND THAT GENETIC PERTURBATIONS OF MASP1 EXPRESSION (BOTH OVEREXPRESSION AND KNOCKDOWN) IN AFRICAN CLAWED FROG (XENOPUS LAEVIS) EMBRYOS LEADS TO COMPLEMENTARY CHANGES IN DORSAL ANTERIOR STRUCTURES SUCH AS ALTERED HEAD SIZE AND CEMENT GLAND SIZE AND SHAPE. ADDITIONALLY, WE FOUND THAT MASP1 MANIPULATION LEADS TO ALTERED GENE EXPRESSION PATTERNS SUGGESTIVE OF EMBRYONIC PATTERNING DEFECTS THAT COULD DISRUPT ECTODERMAL-DERIVED TISSUES, POSSIBLY THROUGH MASP1 INTERSECTION WITH THE BMP SIGNALING PATHWAY. IN THIS PROJECT, WE WILL CONTINUE TO USE XENOPUS LAEVIS AS A MODEL SYSTEM TO ADDRESS OUR CENTRAL HYPOTHESIS THAT MASP1 IS INVOLVED IN ECTODERM PATTERNING THROUGH POSITIVE REGULATION OF THE BMP SIGNALING GRADIENT. FIRST, WE WILL PERFORM TARGETED GENETIC PERTURBATIONS OF MASP1 FOLLOWED BY PHENOTYPIC AND GENE EXPRESSION ANALYSIS TO IDENTIFY A ROLE OF MASP1 PROTEOLYTIC CLEAVAGE IN TISSUE PATTERNING DURING GASTRULATION (AIM 1). NEXT, WE WILL USE BOTH TARGETED (IN VIVO LUCIFERASE REPORTER ASSAY) AND UNBIASED (CO-IMMUNOPRECIPITATION FOLLOWED BY LC/MS) APPROACHES TO IDENTIFY MASP1 TARGETS AND DETERMINE HOW MASP1 REGULATES BMP SIGNALING (AIM 2). THROUGH THIS WORK, WE WILL PROVIDE UNDERGRADUATE AND GRADUATE STUDENTS WITH MEANINGFUL RESEARCH EXPERIENCES IN THE FIELD OF DEVELOPMENTAL BIOLOGY. UPON COMPLETION OF THIS STUDY, WE EXPECT TO DETERMINE THE MECHANISTIC BASIS FOR MASP1 INVOLVEMENT IN EARLY DEVELOPMENT AND IDENTIFY A NEW PLAYER IN REGULATION OF BMP MORPHOGENIC SIGNALING WITH FUTURE IMPLICATIONS FOR INTERVENTIONS OF MASP1- AND BMP-ASSOCIATED DEVELOPMENTAL DISORDERS.

NORMATIVE WIDEBAND ACOUSTIC IMMITTANCE DATA: TOWARD CLINICAL APPLICATION

IDAHO STATE UNIVERSITY FACULTY DEVELOPMENT PROGRAM

THE ROLE OF METAL ION HOMEOSTASIS IN REGULATING BACTERIAL CAPSULE PRODUCTION - PROJECT SUMMARY/ABSTRACT CAPSULAR POLYSACCHARIDE (CPS) PRODUCED BY PATHOGENIC BACTERIA IS A KEY VIRULENCE DETERMINANT FOR BACTERIAL SURVIVAL IN THE HUMAN HOST, BUT KNOWLEDGE OF HOW CPS PRODUCTION IS REGULATED REMAINS LIMITED. GIVEN THE NEED FOR PATHOGENIC BACTERIA TO MODULATE CPS EXPRESSION (THICKNESS) AMONG VARIOUS HOST NICHES DURING DISEASE PROGRESSION, WE POSTULATE HERE THAT AVAILABLE ENVIRONMENTAL FACTORS SUCH AS METAL ION MICRONUTRIENTS CAN INFLUENCE CPS PRODUCTION. THE LONG-TERM GOAL IS TO HELP DEVELOP ALTERNATIVE METAL-BASED ANTIMICROBIAL THERAPEUTICS FOR CLINICAL TREATMENT OF BACTERIAL DISEASES IN HUMANS. THE OVERALL OBJECTIVES IN THIS APPLICATION, WHICH CONSTITUTE THE FIRST STEP TOWARD ATTAINMENT OF THE LONG-TERM GOAL, ARE TO IDENTIFY THE MOLECULAR MECHANISMS BY WHICH CELLULAR METAL ION RATIOS, SPECIFICALLY MANGANESE (MN), ZINC (ZN), AND CALCIUM (CA), INFLUENCE CPS PRODUCTION, WHILE INCREASING EXPOSURE OF UNDERGRADUATES TO RESEARCH AND ENHANCING IDAHO STATE UNIVERSITY’S BIOMEDICAL RESEARCH ENTERPRISE. THE CENTRAL HYPOTHESIS IS THAT METAL ION MICRONUTRIENTS REGULATE CPS BIOGENESIS VIA DIRECT MODULATION OF ENZYME ACTIVITY IN PATHOGENIC BACTERIA USING STREPTOCOCCUS PNEUMONIAE (SPN) AS A GRAM-POSITIVE MODEL BACTERIUM. THE RATIONALE FOR THIS PROJECT IS THAT A MECHANISTIC UNDERSTANDING OF HOW CELLULAR METAL ION RATIOS REGULATE CPS EXPRESSION LEVELS WOULD PROVIDE NEW OPPORTUNITIES FOR THE SUBSEQUENT IDENTIFICATION AND DEVELOPMENT OF TARGETS FOR THE DESIGN OF NOVEL INTERVENTIONS TO TREAT HUMAN PATHOGENIC BACTERIAL INFECTIONS. TO ATTAIN THE OVERALL OBJECTIVES, WE WILL PURSUE THE FOLLOWING SPECIFIC AIMS: 1) IDENTIFY THE MECHANISM(S) WHEREBY BIOAVAILABLE MN/ZN RATIOS AFFECT CPS PRODUCTION; AND 2) DETERMINE THE ROLE OF CA IN MN HOMEOSTASIS AND CPS BIOGENESIS. THE FIRST AIM WILL ASSESS THE PHYSIOLOGICAL AND BIOCHEMICAL IMPACT OF BIOAVAILABLE MN/ZN RATIOS ON SEVERAL MN-UTILIZING ENZYMES INVOLVED IN VARIOUS ARMS OF THE SPN CPS BIOSYNTHETIC PATHWAY. THE SECOND AIM WILL ASSESS THE IMPACT OF CA/MN RATIOS ON THE INTRACELLULAR METAL LANDSCAPE AND CPS BIOSYNTHESIS IN COORDINATION WITH RNASEQ AND PROTEOMIC ANALYSIS. THE OVERALL APPROACH COMBINES CLASSICAL MICROBIOLOGY TECHNIQUES WITH MODERN DAY APPLICATIONS THAT SPAN THE INTERFACE OF BIOLOGY AND CHEMISTRY, THEREBY EXPOSING UNDERGRADUATES TO INTERDISCIPLINARY RESEARCH TECHNIQUES. THE RESEARCH PROPOSED IN THIS APPLICATION IS INNOVATIVE, IN THE APPLICANT’S OPINION, BECAUSE IT REPRESENTS A SUBSTANTIVE DEPARTURE FROM THE STATUS QUO BY FOCUSING ON THE IMPACT OF OVERALL CELLULAR METAL ION MICRONUTRIENT RATIOS AND THEIR CAPACITY TO REGULATE BACTERIAL CPS BIOGENESIS. THE RESEARCH PROPOSED WILL ALSO FURTHER THE UNDERSTANDING OF HOW CELLULAR METAL ION AVAILABILITY SERVE AS SIGNALING FACTORS THAT INFLUENCE GLOBAL CELLULAR CHANGES AND CELLULAR PROGRAMING DURING PATHOGENESIS. THE PROPOSED RESEARCH IS SIGNIFICANT BECAUSE IT IS EXPECTED TO PROVIDE A STRONG FOUNDATION FOR SUBSEQUENT FUTURE DESIGN OF MECHANISTIC AND ALTERNATIVE METAL- BASED DRUG DEVELOPMENT STRATEGIES TO COMBAT HUMAN BACTERIAL PATHOGENS PRONE TO EXHIBITING MULTIDRUG RESISTANCE.

TESTING THE STATE AND TRAIT ACCURACY MODEL: LINKS BETWEEN ACCURACY OF JUDGING AFFECT AND ACCURACY OF JUDGING TRAITS

COLLABORATIVE RESEARCH: RECONSTRUCTING THE MISSING RECORD OF LATE PROTEROZOIC TECTONISM ALONG THE WESTERN MARGIN OF LAURENTIA USING DEEP-TIME THERMOCHRONOLOGY -STUDIES OF SEDIMENTARY ROCKS PROVIDE GEOSCIENTISTS A RECORD OF EARTH?S HISTORY, INCLUDING THE APPEARANCE AND EVOLUTION OF LIFE, THE GROWTH AND DEMISE OF MOUNTAINS, AND HOW THE CLIMATE HAS CHANGED. HOWEVER, NATURAL PROCESSES DRIVEN BY PLATE TECTONICS MEAN THAT THIS SEDIMENTARY RECORD IS INHERENTLY INCOMPLETE. AT DIFFERENT TIMES DURING EARTH?S HISTORY, SOME REGIONS EXPERIENCED SEDIMENT DEPOSITION, WHICH BURIES AND THEREFORE HEATS UP ROCKS, WHILE OTHER REGIONS EXPERIENCED EROSION, WHICH BOTH REMOVES PORTIONS OF THE ROCK RECORD AND COOLS OFF THE ROCKS THAT PERSIST BY BRINGING THEM CLOSER TO EARTH?S SURFACE. THIS STUDY WILL USE THE GEOCHEMICAL SIGNATURES OF ROCK HEATING AND COOLING THAT OCCURS DURING DEPOSITION AND EROSION TO UNDERSTAND THE GEOLOGIC HISTORIES OF AREAS WHERE NO SEDIMENTARY ROCKS REMAIN. SPECIFICALLY, THE STUDY WILL INVESTIGATE THE ANCIENT RECORD OF SUPERCONTINENT BREAKUP, A PROCESS THAT DRIVES CHANGES IN SEA LEVEL, GLOBAL CLIMATE, AND TOPOGRAPHY. THIS PROJECT WILL PROVIDE SUPPORT FOR THREE EARLY-CAREER RESEARCHERS AT DIFFERENT UNIVERSITIES, INCLUDING TWO WOMEN, AND BUILD NEW RELATIONSHIPS AMONG THE COLLABORATING RESEARCH GROUPS. THREE GRADUATE AND NINE UNDERGRADUATE STUDENTS FROM DIFFERENT UNIVERSITIES WILL BE ENGAGED IN COLLABORATIVE, HYPOTHESIS-DRIVEN RESEARCH AND LEARN A RANGE OF FIELD, LABORATORY, AND SCIENCE COMMUNICATION METHODS. THE RESEARCHERS WILL ALSO COLLABORATE WITH THE IDAHO MUSEUM OF NATURAL HISTORY TO CREATE A MOBILE MUSEUM EXHIBIT THAT WILL HIGHLIGHT THE ANCIENT HISTORY OF THE CHARISMATIC MOUNTAIN RANGES IN THE STUDY AREA AND VISIT MUSEUMS THAT SERVE RURAL COMMUNITIES IN THE ROCKY MOUNTAINS. UNCONFORMITIES, WHICH ARE ABUNDANT IN THE ROCK RECORD, ARE TRADITIONALLY VIEWED AS UNFILLABLE GAPS IN THE ROCK RECORD OF EARTH?S HISTORY. HOWEVER, THE THERMAL IMPRINT OF SEDIMENTARY COVER ON THE BASEMENT ROCKS THAT UNDERLIE MANY UNCONFORMITIES PROVIDES A RICH ARCHIVE OF THE OTHERWISE INACCESSIBLE PARTS OF A CONTINENT?S TECTONIC HISTORY. THIS RECORD IS NOW ACCESSIBLE DUE TO RECENT CONCEPTUAL AND ANALYTICAL ADVANCES IN LOW-TEMPERATURE THERMOCHRONOLOGY. THE PRIMARY OBJECTIVE OF THIS STUDY IS TO CONTRIBUTE TO THESE ADVANCES BY TARGETING A CRITICAL GAP IN KNOWLEDGE ABOUT LAURENTIAN TECTONICS, THE BREAKUP OF SUPERCONTINENT RODINIA, WHILE ESTABLISHING AN APPROACH TO DEEP-TIME THERMOCHRONOLOGY THAT CAN DOCUMENT PRECAMBRIAN TECTONIC ACTIVITY IN REGIONS THAT ALSO EXPERIENCED SIGNIFICANT PHANEROZOIC MOUNTAIN BUILDING. THIS STUDY WILL SAMPLE ALONG A 700-KILOMETER-LONG SEGMENT OF WESTERN LAURENTIA?S RIFTED MARGIN, TARGETING BASEMENT ROCKS DIRECTLY BELOW THE GREAT UNCONFORMITY AND USING FOUR CHRONOMETERS TO PRODUCE HOLISTIC TECTONOTHERMAL HISTORIES TO FILL A BILLION-YEAR GAP IN THE ROCK RECORD. THIS STUDY WILL DEMONSTRATE HOW DEEP TIME THERMOCHRONOLOGY CAN PROVIDE A NEW PERSPECTIVE ON THE GEOMETRY AND TECTONIC EVOLUTION OF WESTERN LAURENTIA?S RIFTED MARGIN, WHERE MUCH OR ALL OF THE SEDIMENTARY RECORD OF NEOPROTEROZOIC TECTONISM IS MISSING. THIS CAPABILITY WILL BE TESTED BY (1) ESTABLISHING A CLEAR LINK BETWEEN EXTANT NEOPROTEROZOIC SEDIMENTARY ROCKS AND NEOPROTEROZOIC TECTONOTHERMAL EVENTS IN THE UINTA MOUNTAINS, (2) DOCUMENTING THE PROTEROZOIC THERMAL HISTORIES OF BASEMENT BLOCKS WITH NO OVERLYING NEOPROTEROZOIC STRATA IN THE TETON RANGE AND SOUTHWESTERN MONTANA, AND (3) QUANTIFYING INTRA-MOUNTAIN RANGE VARIABILITY OF PROTEROZOIC THERMAL HISTORIES TO EVALUATE THE SAMPLING SPATIAL RESOLUTION NECESSARY FOR EXTRACTING MEANINGFUL TECTONIC INFORMATION FROM THE DEEP-TIME THERMOCHRONOLOGIC RECORD. THIS PROJECT IS JOINTLY FUNDED BY THE EAR TECTONICS PROGRAM AND BY THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

ALCOHOL, ERT AND COGNITION IN MENAPAUSAL WOMEN

IDAHO YOUTH SUICIDE PREVENTION EARLY INTERVENTION PROJECT

CDS&E: ADAPTIVE LEARNING FOR MULTIVARIATE CALIBRATION WITH BIG DATA ATTRIBUTES

ORIGINS OF MICROBIAL IRON RESPIRATION NASA'S CURRENT PALETTE OF ASTROBIOLOGY RESEARCH INCLUDES STUDIES ON EXTREME ENVIRONMENTS AROUND THE WORLD, WITH

BASALT (BIOLOGIC ANALOG SCIENCE ASSOCIATED WITH LAVA TERRAINS) IS A MULTIINSTITUTIONAL PROJECT IN CONJUNCTION WITH NASA SCIENTISTS TO INVESTIGATE THE

HEALTH CARE AND OTHER FACILITIES

IDAHO STATE UNIVERSITY AND NUCLEAR SCIENCE FELLOWSHIP PROGRAM

IDAHO STATE UNIVERSITY NUCLEAR EDUCATION FELLOWSHIP PROGRAM

IDENTIFICATION OF ELECTROPHYSIOLOGICAL INDICES OF SPEECH SOUND PERCEPTION AND CHA

CAREER: INTRODUCING DYNAMIC SULFUR CHEMISTRY INTO HYDROGELS TO PROMOTE WATER RETENTION AND HEALTHY MICROBE GROWTH IN SOIL -NON-TECHNICAL SUMMARY THE WORLD?S POPULATION IS GROWING RAPIDLY, REQUIRING THE DRAMATIC EXPANSION OF FOOD PRODUCTION. COMBINED WITH INCREASED URBANIZATION, CLIMATE CHANGE, AND COMPETITION FOR WATER, THIS POSES AN EXTREME CHALLENGE FOR THE AGRICULTURAL INDUSTRY. THESE CHANGES ALONE ARE DIFFICULT TO MANAGE, MUCH LESS ACHIEVE SUSTAINABLY, WITH LIMITED IMPACTS ON ECONOMICS, PUBLIC HEALTH, AND SURROUNDING ECOSYSTEMS. AGRICULTURE IS THE TOP CONSUMER OF WATER IN THE UNITED STATES. WITH MUCH OF THE WESTERN U.S. EXPERIENCING EXTREME DROUGHT IN RECENT YEARS, THE WATER WE DO HAVE MUST BE USED MORE EFFICIENTLY. ALTHOUGH IT IS ESTABLISHED THAT SULFUR PROVIDES MANY BENEFITS TO PLANTS, UNTIL RECENTLY, THERE HAS BEEN AMPLE SULFUR DEPOSITION INTO SOILS FROM BURNING FOSSIL FUELS. AS SOCIETY MOVES AWAY FROM PETROLEUM AND AIR QUALITY STANDARDS IMPROVE, SULFUR DEPOSITED IN SOIL WILL CONTINUE TO DECREASE, INCREASING THE PRESSURE TO ADD SULFUR-BASED FERTILIZERS TO CROPS. DESPITE THE NECESSITY OF SULFUR FOR SUCCESSFUL CROP PRODUCTION, IT ALSO POSES A POLLUTION RISK. SINCE COMMONLY USED FERTILIZERS HAVE LESS THAN 50% UPTAKE BY CROPS, SULFUR-BASED FERTILIZERS ARE ALSO UNLIKELY TO BE FULLY ASSIMILATED AND COULD LEACH INTO SURFACE WATERS, NEGATIVELY IMPACTING THE ENVIRONMENT. THIS WORK AIMS TO CREATE ABSORBENT, SULFUR-BASED MATERIALS TO AID IN WATER RETENTION AND PROVIDE CONTROLLED DELIVERY OF KEY NUTRIENTS, INCLUDING SULFUR, TO THE SOIL. MORE EFFECTIVE NUTRIENT DELIVERY TO PLANTS COULD ENHANCE CROP PRODUCTION WHILE LIMITING THE IMPACT ON SURROUNDING ECOSYSTEMS. EXPOSING THESE MATERIALS TO COMMON BACTERIA FOUND IN SOIL WILL HELP DETERMINE THE IMPACTS OF THESE MATERIALS ON MICROBES IN THE SOIL. ADDITIONALLY, THIS RESEARCH PROVIDES UNDERGRADUATES WITH THE TRAINING AND MENTORING NECESSARY TO JOIN THE STEM WORKFORCE AFTER GRADUATION. IT ALSO ESTABLISHES A SUMMER RESEARCH EXPERIENCE (SRE) FOCUSED ON SCIENTIFIC COMMUNICATION FOR ALL RESEARCH STUDENTS IN THE CHEMISTRY DEPARTMENT. THE SRE WILL ENHANCE STUDENTS? ABILITY TO EFFECTIVELY LEARN FROM AND SHARE DATA WITH OTHER SCIENTISTS AS WELL AS BETTER SHARE THEIR RESULTS WITH THE GENERAL POPULATION. OVER TIME, THE SRE WILL INCLUDE UNDERSERVED AND LOW-INCOME HIGH SCHOOL STUDENTS IN THE REGION CREATING CONNECTIONS BETWEEN THEM AND HIGHER EDUCATION IN STEM. TECHNICAL SUMMARY SULFUR HAS BEEN USED FOR CENTURIES AS A PESTICIDE IN AGRICULTURE. HOWEVER, ITS APPLICATION AS A FERTILIZER HAS NOT BEEN CONSIDERED UNTIL RECENTLY. BURNING FOSSIL FUELS HAS DEPOSITED SULFUR INTO THE ENVIRONMENT OVER MANY DECADES. AS SOCIETY MOVES AWAY FROM PETROLEUM AND AIR QUALITY CONTINUES TO IMPROVE, SULFUR DEPOSITED INTO THE SOIL WILL DECREASE, INCREASING THE PRESSURE TO ADD SULFUR-BASED FERTILIZERS TO CROPS. INVERSE VULCANIZATION (IV) HAS ENABLED THE EXPANSION OF SULFUR-BASED MATERIALS OVER THE PAST DECADE. IV USES THE HEAT LABILE BONDS IN S8 TO ACT AS THE INITIATOR, SOLVENT, AND MONOMER, LEADING TO POLYSULFIDES WITH SULFUR-CONTENTS RANGING FROM 20-90%. HOWEVER, THE HYDROPHOBICITY OF S8 MAKES POLYMERIZING POLAR MONOMERS CHALLENGING, YIELDING VERY FEW MATERIALS THAT CAN INTERACT WITH WATER. GARLIC ESSENTIAL OIL (GEO), RICH IN DIALLYL DISULFIDES, OFFERS A STRATEGY TO COMBINE SULFUR WITH POLAR MONOMERS. BY INTRODUCING DYNAMIC SULFUR-CHEMISTRY INTO A HYDROPHILIC GEL PLATFORM, THIS WORK AIMS TO DEVELOP A NEW CLASS OF SULFUR-BASED POLYMERS AND PROVIDE INSIGHT INTO THE ROLE OF SULFUR-LOOPS, GEO, AND THE 3D POLYMER STRUCTURE ON THE MATERIAL PROPERTIES. THESE MATERIALS WILL BE EXPOSED TO MICROBES, KNOWN TO PERFORM REDOX CHEMISTRY WITH SULFUR, TO DETERMINE IF THEY CAN UTILIZE THE SULFUR WITHIN THESE GELS. FURTHER ANALYSIS WILL CONNECT OUR UNDERSTANDING OF THE POLYMER STRUCTURE AND OXIDATION STATE OF SULFUR TO THE BACTERIAL RESPONSE AND PROVIDE INSIGHT INTO BACTERIAL MODIFICATION OF THE POLYSULFIDES. ADDITIONAL TESTING WITH SOIL BACTERIA WILL BE PERFORMED TO BEGIN TO UNDERSTAND HOW SULFOGELS IMPACT THE SOIL MICROBIOME. FURTHER ANALYSES WILL DETERMINE IF MICROBES ARE ABLE TO ACCESS THE SULFUR WITHIN THE POLYMER AND CONVERT IT TO A FORM ACCESSIBLE TO PLANTS SUCH AS SULFATES. THESE ANALYSES WOULD AID IN THE DEVELOPMENT OF MATERIALS THAT CAN PROVIDE THE CONTROLLED DELIVERY OF WATER, NUTRIENTS, AND BENEFICIAL BACTERIA TO CROPS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

TO SUPPORT COORDINATED COOPERATIVE RESEARCH, TECHNICAL ASSISTANCE, EDUCATION AND TRAINING, AND USABLE KNOWLEDGE DEVELOPMENT TO INFORM SCIENCE-BASED MANAGEMENT OF THE NATIONAL PARK SYSTEM. TO FACILITATE MULTI-DISCIPLINARY SCIENCE AND INTEGRATED INFORMATION PRODUCTS RELATED TO THE RESOURCES OF THE NATIONAL PARK SYSTEM. TO MAINTAIN A COMPREHENSIVE NETWORK COOPERATIVE STUDY UNITS AS WILL PROVIDE FULL GEOGRAPHIC AND TOPICAL COVERAGE FOR RESEARCH, TECHNICAL ASSISTANCE, AND EDUCATIONAL ACTIVITIES RELATED TO THE RESOURCES CONTAINED IN UNITS OF THE NATIONAL PARK SYSTEM AND THEIR LARGER REGIONS. THE PRIMARY GOAL OF THIS FIVE-YEAR PROJECT IS TO DEVELOP A CLIMATE VULNERABILITY ASSESSMENT FOR THE FLUVIAL AND TERRESTRIAL LANDFORMS AND INFRASTRUCTURE WITHIN THE UPPER YELLOWSTONE RIVER WATERSHED. THIS INCLUDES THE AREAS AFFECTED BY THE JUNE, 2022 FLOOD AS WELL AS OTHER SUB-WATERSHEDS WITHIN AND ADJACENT TO THE PARK WITH FEDERAL ASSETS. THIS ASSESSMENT IS ACCOMPLISHED THROUGH BOTH THE CHARACTERIZATION OF THE IMPACTS OF THE 2022 EVENT AND THE CONSIDERATION OF HOW AND WHERE FUTURE CLIMATE EVENTS MAY CAUSE FLOODING AND HILLSLOPE INSTABILITY. BENEFICIARIES INCLUDE STATE AND LOCAL GOVERNMENTS, FEDERALLY RECOGNIZED INDIAN TRIBAL GOVERNMENTS, PUBLIC PRIVATE NONPROFIT ORGANIZATIONS, NONPROFIT INSTITUTIONS OF HIGHER EDUCATION, AND INDIVIDUALS (INCLUDING MEMBERS OF THE GENERAL PUBLIC).FOR MORE INFORMATION AND GUIDANCE, REFER TO NPS FINANCIAL ASSISTANCE POLICY GUIDANCE DOCUMENT ON USASPENDING.GOV AWARD DESCRIPTIONS (PROJECT ABSTRACTS), OR CONTACT THE NPS FINANCIAL ASSISTANCE POLICY OFFICE AT FINANCIAL ASSITANCE POLICY@NPS.GOV.

COLLABORATIVE RESEARCH: RUI: ZERO-ORDER TO FIRST-ORDER: HYDROLOGIC DRIVERS OF SURFACE-SUBSURFACE STORAGE DYNAMICS IN THAWING PERMAFROST LANDSCAPES

RECOVER 2.0: CLOUD-ENABLED WILDFIRE DECISION SUPPORT SYSTEM

MRI: PROPOSAL TO PURCHASE A ESEM WITH CL, STEM, AND EDX, AT IDAHO STATE UNIVERSITY

ENHANCING IRRADIATION TOLERANCE OF STEELS VIA NANOSTRUCTURING BY INNOVATIVE MANUFACTURING TECHNIQUES

FOOD INSECURITY, OBESITY, AND IMPULSIVE FOOD CHOICE

ANTIBIOTIC SPECTRUM SCORING TO MEASURE HOSPITAL-LEVEL ANTIBIOTIC DE-ESCALATION

IDENTIFICATION OF FUNCTIONAL TARGETS FOR ASBESTOS INDUCED AUTOANTIBODIES

FUSION OF REMOTELY SENSED DATA SOURCES FOR MODELING EOLIAN SOIL TRANSPORT IN HETEROGENEOUS TERRAIN

IDAHO STATE UNIVERSITY NUCLEAR EDUCATION FELLOWSHIP PROGRAM

IDAHO STATE UNIVERSITY TRIO STUDENT SUPPORT SERVICES (SSS)

USING INTEGRAL EQUATIONS TO CAPTURE SPATIOTEMPORAL RELATIONS IN THE BRAIN - PROJECT SUMMARY MEDICAL RECORDINGS CONTAIN DYNAMICAL INFORMATION THAT CAN PROVIDE QUANTITATIVE PATHOLOGICAL FINGERPRINTS THAT PROVE CRUCIAL TO CORRECT DIAGNOSTIC. BRAIN RECORDINGS ARE PARTICULARLY IMPORTANT FOR COGNITIVE STUDIES, AS THE STATE OF THE BRAIN AT A SINGLE INSTANT IS NOT SUFFICIENT TO DETERMINE COGNITION, WHICH IS A HIGHLY COMPLEX DYNAMICAL PROCESS. CONSEQUENTLY, IN ORDER TO CORRECTLY DIAGNOSE THE SEVERITY OF COGNITIVE PATHOLOGIES, IT IS IMPORTANT TO ANALYZE BRAIN DYNAMICS THROUGH THEIR RECORDINGS. MACHINE LEARNING (ML) ALGORITHMS BASED ON STATIC APPROACHES TEND TO MISS THE DYNAMICAL SPATIOTEMPORAL RELATIONS OF THE RECORDINGS, WHILE ML METHODS BASED ON LOCAL EQUATIONS DO NOT TAKE INTO ACCOUNT THE LONG-DISTANCE SPATIOTEMPORAL RELATIONS. HERE, WE PROPOSE TO USE ML METHODS BASED ON NONLOCAL EQUATIONS AND OPERATORS THAT ALLOW US TO EXTRACT A DYNAMICAL FINGERPRINT OF THE BRAIN, AND USE THIS TO DEVELOP DIAGNOSTIC CONTINUOUS SCORES (SPECTRA OF SEVERITY). THE USE OF NONLOCAL EQUATIONS SUCH AS INTEGRAL EQUATIONS AND INTEGRO-DIFFERENTIAL EQUATIONS TO MODEL THE BRAIN HAS BEEN PIONEERED DECADES AGO. HOWEVER, THESE STUDIES HAVE NEVER BEEN EXTENDED TO ML METHODS, EXCEPT IN OUR RECENT PRELIMINARY STUDIES. OUR FOCUS, THEREFORE, IS TO APPLY SUCH METHODOLOGIES TO MODEL (PREDICT) BRAIN DYNAMICS, AND EMPLOY THE LEARNED MODELS TO EXTRACT THE MODEL STATES (SELF-ATTENTION) THAT CHARACTERIZE BRAIN COGNITION. THESE STATES WILL THEREFORE BE USED TO DEVELOP DIAGNOSTIC SCORES.

MODULATION OF BREAST CANCER METASTASIS USING BONE-TARGETED DELIVERY OF A SMALL ANTI-CANCER PEPTIDE - PROJECT SUMMARY BREAST CANCER, THE MOST COMMONLY DIAGNOSED CANCER AND THE SECOND CAUSE OF WOMEN’S CANCER MORTALITY REMAINS A GLOBAL PUBLIC HEALTH PROBLEM. BREAST CANCER CAN EVENTUALLY METASTASIZE TO THE BONE, LUNGS, LIVER, BRAIN, AND SOFT TISSUES IN MORE THAN 20-40% OF CASES OVER DECADES AFTER THE PRIMARY DIAGNOSIS. THIS PHENOMENON IS PARTICULARLY PROMINENT IN ER+ BC, AS IT REMAINS DORMANT FOR YEARS. TRIPLE-NEGATIVE BREAST CANCER (TNBC) ACCOUNTS FOR 10–20% OF ALL BREAST CANCER CASES AND CARRIES A POOR PROGNOSIS DUE TO ITS HIGHLY AGGRESSIVE NATURE, HIGH INCIDENCE OF RELAPSE, AND METASTASIS. TNBC IS REFRACTORY TO TREATMENTS WITH A HIGHER MORTALITY RATE. DESPITE THEIR SEVERE ADVERSE EFFECTS, CYTOTOXIC CHEMOTHERAPY REMAINS THE TREATMENT MAINSTAY. TNBC FREQUENTLY METASTASIZES TO BONE AND OTHER TISSUE WHERE SYSTEMIC THERAPIES FAIL TO PENETRATE ADEQUATELY. PREVIOUS STUDIES SHOWED THAT ANGIOTENSIN 1-7 (ANG1-7) INHIBITS CANCER CELL PROLIFERATION AND METASTASIS IN CULTURE AND XENOGRAFT ANIMAL MODELS AND PRESENTS A FAVORABLE SAFETY PROFILE. YET, ANG1-7’S BIOLOGICAL ACTIVITY IS HAMPERED BY POOR PHARMACOKINETICS (PK) AND SHORT HALF-LIFE (T1/2). THUS, IMPROVING ITS T1/2 AND PK PROFILE AND EXPLICITLY TARGETING PRIMARY AND SECONDARY CANCER SITES IS VITAL TO RECOVERING ANG1-7 ANTI-CANCER EFFICACY. A NOVEL BONE-TARGETING ANG1-7 CONJUGATE (ANG CONJ) HAS BEEN DEVELOPED IN OUR LABORATORY. OUR INNOVATIVE STRATEGY TO ADDRESS THESE GOALS IS TO TARGET ANG1-7 TO THE BONE. SINCE BONE IS ONE OF THE MOST COMMON SITES OF METASTASIS IN TNBC PATIENTS, TARGETING THE ANTI-CANCER PEPTIDE ANG1-7 TO THE BONE WILL CREATE A DRUG DEPOT ON THE BONE WITH SUSTAINED DELIVERY OF ADEQUATE LEVELS OF ANG1-7 TO INHIBIT TUMOR METASTASIS IN THE BONE AND OTHER TISSUES. INDEED, OUR PRELIMINARY STUDIES DEMONSTRATE THAT THE ANG CONJ HAS >10-FOLD GREATER T1/2, FAVORABLE BONE TISSUE DISTRIBUTION, AND SIGNIFICANTLY INCREASED ANTI-CANCER EFFECTS IN VITRO AND IN VIVO. OUR LONG-TERM GOAL IS TO ADVANCE THE APPLICATION OF THIS NOVEL AND SAFE ANG CONJ TO PREVENT AND TREAT METASTATIC TNBC AND TO PROVIDE AN EFFECTIVE ALTERNATIVE TO THE CURRENT INVASIVE AND HIGHLY TOXIC TREATMENT MODALITIES. EXPECTED OUTCOMES: ANG CONJ WILL PROVE SAFE AND EFFECTIVE IN MODELS OF METASTATIC TNBC. OUR APPROACH WILL PREVENT TUMOR METASTASIS TO THE BONE BY TARGETING THE SITE AND PROVIDING SUSTAINED PLASMA CONCENTRATION OF ACTIVE PEPTIDES TO PROTECT OTHER TISSUE. ADVANCING THIS STRATEGY TO THE CLINIC WOULD OFFER A MUCH-NEEDED ALTERNATIVE TO TRADITIONAL TOXIC CHEMOTHERAPY IN TNBC THAT COULD BE APPLIED TO DIFFERENT TYPES OF REFRACTORY CANCERS, SUCH AS LUNG, COLORECTAL, AND PROSTATE CANCERS. PAGE 1 OF 1

MICROVASCULAR DYSFUNCTION IN HYPERHOMOCYSTEINEMIA

BCAL-MAPWINDOW WATERSHED MODELING WITH LIDAR

COLLABORATIVE RESEARCH: THE HOT SPRINGS VILLAGE SITE: A WINDOW TO SOUTHERN BERING SEA PALEO-ECOSYSTEMS AND HUMAN - LANDSCAPE INTERACTIONS.

RUI: DYNAMIC NET ANALYTE SIGNAL MODELING FOR MULTIVARIATE CALIBRATION AND MAINTENANCE

PRENYLCYSTEINE METABOLISM AND PHYTOHORMONE SIGNALING IN ARABIDOPSIS

HEALTH CARE AND OTHER FACILITIES

MRI: ACQUISITION OF A 400 MHZ NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROMETER AT IDAHO STATE UNIVERSITY

EXPERIMENTAL BREEDER REACTOR II BENCHMARK EVALUATION

DETERMINANTS OF SODIUM CHANNEL FUNCTION: ION PAIR INTERACTIONS ACROSS DOMAINS

INFRARED THERMAL IMAGING FOR USE IN RESTORATION OF DEFACED SERIAL NUMBERS

THE SUBSEA (SYSTEMATIC UNDERWATER BIOGEOCHEMICAL SCIENCE AND EXPLORATION ANALOG) PROGRAM WILL CONDUCT REAL (NON-SIMULATED) TELEROBOTIC SCIENCE TO UNDERSTAND THE HABITABILITY POTENTIAL OF OCEAN WORLDS IN OUR SOLAR SYSTEM. OUR SCIENCE WILL INCLUDE OBSERVATION INSTRUMENT DATA GATHERING AND SAMPLE COLLECTION FOCUSED ON FLUID VENTING AT ISOLATED SEAMOUNTS IN THE DEEP OCEAN AS ANALOG ENVIRONMENTS TO HYDROTHERMAL SYSTEMS ON OTHER OCEAN WORLDS. WE WILL CONDUCT OUR SCIENTIFIC FIELDWORK FROM THE EXPLORATION VESSEL (E/V) NAUTILUS WHICH IS EQUIPPED WITH THE HERCULES AND ARGUS REMOTELY OPERATED VEHICLES (ROVS). ACCESS TO THIS INFRASTRUCTURE IS ENABLED THROUGH IN-KIND SUPPORT FROM THE NATIONAL OCEANOGRAPHIC AND ATMOSPHERIC ADMINISTRATION (NOAA) OFFICE OF OCEAN EXPLORATION AND RESEARCH (OER). THESE ROVS ARE CONTROLLED UNDER LOW LATENCY FEEDBACK CONDITIONS BY PROXIMAL (SHIP-BASED) HUMAN OPERATORS WHO ARE PROVIDED SCIENTIFIC SUPPORT AND EXPLORATION DIRECTION BY A REMOTE DISTRIBUTED SCIENCE TEAM (DST) WHO ARE LOCATED AT EXPLORATION COMMAND CENTERS (ECCS) THROUGHOUT THE U.S. AND CONNECTED TO THE NAUTILUS VIA A TELEPRESENCE-ENABLED COMMUNICATIONS INFRASTRUCTURE.

VIRTUAL ZOOARCHAEOLOGY OF THE ARCTIC PROJECT (VZAP)

DLT GRANTS - CARES ACT - EDUCATIONAL

CAS: RECYCLING SULFUR PETROLEUM WASTE TO FABRICATE METAL CAPTURE AND ADHESIVE POLYSULFIDES

COLLABORATIVE RESEARCH: LINKING CRUSTAL AND SURFACE PROCESSES TO THEIR IMPACTS ON THE BIOSPHERE, WESTERN ANATOLIA -ANATOLIA IS AN IMPORTANT EPICENTER FOR DOCUMENTING THE TIMING OF MAJOR FAUNAL DISPERSION ON EARTH FOLLOWING ESTABLISHMENT OF THE ?GOMPHOTHERIUM LANDBRIDGE? THAT OCCURRED MILLIONS OF YEARS AGO. FAUNAL MIGRATION INCLUDED EMIGRATION OF HOMINOIDS FROM AFRICA TO EURASIA. HOWEVER, THERE IS A DELAY OF AT LEAST 2 MILLION YEARS (MYR) AND POSSIBLY UP TO 6 MYR BETWEEN ESTABLISHMENT OF THE LANDBRIDGE AND DISPERSAL OF HOMINOIDS TO CENTRAL ANATOLIA. HIGH ELEVATIONS IN WESTERN ANATOLIA MAY EXPLAIN THIS DELAY IN FAUNAL DISPERSION, AS MOUNTAIN RANGES, LIKE THE OCEANIC PASSAGES THAT PRECEDE LANDBRIDGES, POSE FORMIDABLE BARRIERS TO FAUNAL DISPERSION. IN THIS STUDY, SCIENTISTS WILL COMBINE DATASETS OF EARTH'S CRUST (STRUCTURAL ANALYSIS, THERMOCHRONOLOGY, CRUSTAL THICKNESS) WITH SURFACE EXPRESSION (BASIN EVOLUTION AND SURFACE ELEVATION) TO DOCUMENT HOW THE FORMATION OF MOUNTAINS MAY HAVE POTENTIALLY IMPACTED FAUNAL MIGRATION. THIS PROJECT ENDEAVORS TO ESTABLISH AND STRENGTHEN INTERNATIONAL PARTNERSHIPS AMONG FOUR INSTITUTIONS IN THE USA, CANADA, AND T?RKIYE WHERE FIELD WORK WILL BE CONDUCTED. THE PROJECT WILL COLLECTIVELY CONTRIBUTE TO THE ACADEMIC GROWTH AND TRAINING OF SEVERAL GRADUATE AND UNDERGRADUATE STUDENTS INCLUDING THROUGH ENGAGEMENT IN WORKSHOPS AND JOINT FIELD TRIPS THAT COMBINE EXPERTISE FROM EACH INSTITUTION. RESULTS FROM THIS MULTIDISCIPLINARY RESEARCH WILL COVER A WIDE RANGE OF SPATIAL AND TEMPORAL SCALES NECESSARY TO LINK CRUSTAL AND BASIN PROCESSES TO THEIR SURFICIAL, ENVIRONMENTAL, AND BIOLOGICAL IMPACTS. WESTERN ANATOLIA IS CONSIDERED TO HAVE BEEN AT LOW ELEVATIONS SINCE THE EOCENE. HOWEVER, PREVIOUS RESEARCH PLACES THE PRE-EXTENSIONAL CRUSTAL THICKNESS AT 55?60 KM PREDICTING ELEVATIONS OF 3.5?4.1 KM (IF IN ISOSTATIC EQUILIBRIUM). THIS HAS DIRECT IMPLICATIONS FOR THE TIMING AND LOCATION OF FAUNAL MIGRATION CORRIDORS. TECTONIC RECONSTRUCTION OF THIS REGION IS HAMPERED BY MULTIPLE FACTORS: (1) BASINS ARE CHARACTERIZED BY WIDELY DISPERSED AND INCOMPLETE STRATIGRAPHIC SECTIONS AND LACK DETAILED CHRONOSTRATIGRAPHIC CONTROL, (2) EXISTING STRUCTURAL RECONSTRUCTIONS ARE IN CONFLICT ON THE GEOMETRY OF OLIGOCENE?EARLY MIOCENE EXTENSION, (3) PALEO-CRUSTAL THICKNESS ESTIMATES ARE LIMITED, AND (4) NO PROXY-BASED PALEOELEVATION ESTIMATES EXIST. THIS PROJECT WILL INVESTIGATE THE OLIGOCENE?PLEISTOCENE EVOLUTION OF SEDIMENTARY BASINS, EXTENSIONAL STRUCTURES, CRUSTAL THICKNESS, AND PALEOELEVATION IN THIS HIGHLY EXTENDED REGION. REFINED AGE CONTROL AND STRATIGRAPHIC CORRELATIONS, AS WELL AS NEW CRUSTAL THICKNESS ESTIMATES FROM WHOLE-ROCK AND DETRITAL ZIRCON GEOCHEMISTRY AND PROXY-BASED PALEOALTIMETRY, WILL PROVIDE CONTEXT TO TEST MODELS EXPLAINING SINGLE- OR DOUBLY-VERGENT EXTENSION USING THERMOCHRONOMETRIC ANALYSIS AND THERMOKINEMATIC MODELING. COLLECTIVELY, THIS PROJECT WILL ASSESS GENERAL MODELS OF CRUSTAL EVOLUTION DURING SUBDUCTION TO DETERMINE WHETHER AIRY ISOSTASY WAS THE PRIMARY CONTROL ON ELEVATION OR IF ALTERNATIVE MODELS SUCH AS PRATT ISOSTASY OR DYNAMIC, MANTLE SUPPORT ARE PERMISSIBLE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

EAGER: VIRTUAL ARCTIC ARCHEOLOGICAL REPOSITORIES AND THE DEMOCRATIZATION OF SCIENCE: THE ALASKA PENINSULA PROJECT

FAST AWARDEE-IDAHO STATE UNIVERSITY

POSTDOCTORAL FELLOWSHIP: EAR-PF: FIELD TESTS OF MESOZOIC TERRANE ACCRETION IN SOUTH AMERICA -THE ANDES OF SOUTH AMERICA ARE A CLASSIC EXAMPLE OF HOW MOUNTAINS ARE BUILT ALONG CONTINENTAL MARGINS. FOR DECADES, SCIENTISTS HAVE BELIEVED THAT THIS RANGE FORMED THROUGH A RELATIVELY STEADY, LONG-TERM PROCESS OF OCEANIC TECTONIC PLATES SLIDING BENEATH THE WESTERN EDGE OF SOUTH AMERICA. HOWEVER, RECENT IMAGERY OF EARTH?S DEEP INTERIOR CHALLENGES THIS VIEW, SUGGESTING INSTEAD THAT A CHAIN OF VOLCANIC ISLANDS?PERHAPS RESEMBLING MODERN JAPAN?MAY HAVE CRASHED INTO AND MERGED WITH SOUTH AMERICA ABOUT 100 MILLION YEARS AGO. BY STUDYING THE CHEMISTRY, AGE, AND CHARACTERISTICS OF ANCIENT VOLCANIC AND SEDIMENTARY ROCKS IN CENTRAL CHILE, THIS RESEARCH WILL TEST THESE TWO MODELS. ANSWERING THIS FUNDAMENTAL QUESTION WILL IMPROVE OUR UNDERSTANDING OF HOW CONTINENTS GROW, HOW EARTH?S CRUST IS RECYCLED BACK INTO THE MANTLE, AND HOW AND WHERE VALUABLE MINERAL RESOURCES ARE FORMED. THIS FELLOWSHIP WILL ADVANCE SCIENCE EDUCATION BY PROVIDING HANDS-ON RESEARCH OPPORTUNITIES FOR UNDERGRADUATE STUDENTS AND DEVELOPING GEOLOGY FIELD TRIPS FOR RURAL IDAHO HIGH SCHOOLERS. ADDITIONALLY, THE PROJECT WILL STRENGTHEN U.S. SCIENCE BY CONTRIBUTING TO GROWTH OF A NEW CUTTING-EDGE LABORATORY FACILITY AT IDAHO STATE UNIVERSITY, STRENGTHENING INTERNATIONAL COLLABORATIONS, AND PREPARING THE FELLOW FOR A PROFESSORSHIP AT A RESEARCH-INTENSIVE U.S. INSTITUTION. THIS PROJECT WILL TEST COMPETING TECTONIC MODELS FOR THE MESOZOIC EVOLUTION OF THE SOUTH AMERICAN MARGIN. WHEREAS TRADITIONAL INTERPRETATIONS FAVOR UNINTERRUPTED, EAST-DIPPING SUBDUCTION SINCE CARBONIFEROUS TIME, RECENT GEOPHYSICAL STUDIES PROPOSE MESOZOIC ACCRETION OF AN INTRA-OCEANIC ISLAND ARC FOLLOWING CLOSURE OF A REMNANT OCEAN BY WEST-DIPPING OR DIVERGENT DOUBLE SUBDUCTION. THIS RESEARCH WILL EVALUATE THESE HYPOTHESES BY INVESTIGATING TWO MESOZOIC OUTCROP BELTS IN THE COASTAL AND PRINCIPAL CORDILLERAS OF CENTRAL CHILE (~31?36 ?S). IGNEOUS ZIRCON U-PB GEOCHRONOLOGY WILL BE COMBINED WITH TRACE ELEMENT AND LU-HF GEOCHEMISTRY TO DETERMINE THE NUMBER AND CHARACTER OF MESOZOIC MAGMATIC ARC(S) PRESERVED IN THE REGION. THE PROJECT WILL ALSO INVESTIGATE THE SEDIMENTARY RECORD TO DETERMINE IF MESOZOIC DEPOSITION OCCURRED WITHIN A SINGLE BACK-ARC BASIN, OR TWO OPPOSITELY-FACING FOREARC BASINS LATER JOINED ALONG A CRYPTIC SUTURE. DETRITAL ZIRCON PETROCHRONOLOGY WILL BE INTEGRATED WITH SANDSTONE PETROGRAPHY TO TEST WHETHER THESE DEPOSITS RECEIVED INPUT FROM DISTINCT SOURCE TERRANES OR IF THEY SHARED A COMMON SOUTH AMERICAN PROVENANCE. RESULTS SHOWING A SINGLE MAGMATIC TREND AND SIMILAR SEDIMENT SOURCES BETWEEN BASIN SEGMENTS WILL SUPPORT A HISTORY OF CONTINUOUS EAST-DIPPING SUBDUCTION, WHEREAS EVIDENCE FOR TWO COEVAL, GEOCHEMICALLY DISTINCT ARCS FEEDING SEPARATE FOREARC BASINS MAY INDICATE A MAJOR TERRANE COLLISION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

16-452, WESTERN GULF OF ALASKA SALMON AND OTHER HARVESTS ON FEDERAL LANDS AND WATERS

GP-IN: PATHWAYS TO TRIBAL GEOSCIENCES CAREERS THROUGH CULTURAL CONNECTIONS TO ICONIC LANDSCAPES

REU SITE FOR APPLIED NUCLEAR PHYSICS

ECOLOGY OF GREATER SAGE-GROUSE AND SAGEBRUSH ECOSYSTEMS AT MULTIPLE SPATIAL SCALES

12-450 ALEUTIAN ISLANDS SALMON AND OTHER SUBSISTENCE HARVESTS

BRING-IT: BIOMEDICAL RESEARCH INVESTING IN GROWTH AND ISU TALENT - PROJECT SUMMARY IDAHO STATE UNIVERSITY (ISU) IS A RESOURCE-LIMITED, REGIONAL, R2 DOCTORAL-GRANTING INSTITUTION IN A RURAL, MOUNTAIN WEST STATE. AS THE STATE’S DESIGNATED LEAD FOR TRAINING IN THE HEALTH PROFESSIONS AND A PARTICIPATING MEMBER OF THE STATEWIDE IDAHO INBRE PROGRAM (NIH IDEA NETWORK OF BIOMEDICAL RESEARCH EXCELLENCE), ISU HAS SIGNIFICANT POTENTIAL FOR GROWING ITS BIOMEDICAL RESEARCH PORTFOLIO. TO BUILD TOWARD A STRONGER FUTURE IN BIOMEDICAL RESEARCH, ISU NEEDS A CLEAR PICTURE OF THE INSTITUTIONAL CAPACITY AND RESEARCH ENVIRONMENT. A NEEDS ASSESSMENT AND AN ACTION PLAN THAT SPECIFICALLY HONES IN ON STRENGTHENING THE BIOMEDICAL RESEARCH ENTERPRISE HAS NEVER HAPPENED AT ISU, AND IT IS MUCH NEEDED. OUR LONG-TERM GOALS ARE TO STRENGTHEN BIOMEDICAL RESEARCH INFRASTRUCTURE AT ISU AND TO CREATE A RESEARCH ENVIRONMENT WHERE FACULTY AND STUDENTS IN THE BIOMEDICAL SCIENCES CAN FLOURISH. THE OBJECTIVE OF BRING-IT: BIOMEDICAL RESEARCH INVESTING IN GROWTH AND ISU TALENT IS TO DEVELOP AN INSTITUTION-WIDE AND DATA-INFORMED ACTION PLAN THAT WILL GUIDE IMPROVEMENTS IN BIOMEDICAL RESEARCH CAPACITY. UNIVERSITY LEADERSHIP WILL CHAMPION THE ACTION PLAN, WHICH WILL BE DEVELOPED BY INSTITUTIONAL COLLABORATORS AT DIFFERENT LEVELS OF THE RESEARCH ENTERPRISE. TO ATTAIN THE OBJECTIVE OF THIS APPLICATION, WE WILL CREATE A PRACTICAL ROADMAP, WITH BOTH SHORT-TERM AND LONG-TERM GOALS, FOR STRENGTHENING THE FUTURE OF BIOMEDICAL RESEARCH AT ISU IN WAYS THAT WILL LEAD THE INSTITUTION AND FACULTY TO BE MORE COMPETITIVE FOR NIH FUNDING. INSTITUTIONAL LEADERSHIP IS COMMITTED TO SEEING THROUGH IMPLEMENTATION OF THE ACTION PLAN. THE OVERALL IMPACT WILL REVERBERATE ACROSS THE UNIVERSITY, WITH ISU BECOMING BETTER POSITIONED TO SECURE INDIVIDUAL RESEARCH PROJECT GRANTS (E.G., R01S), AS WELL AS CAPACITY-BUILDING GRANTS (E.G., COBRES AND CTRS). OUTCOMES ARE EXPECTED TO HAVE A POSITIVE IMPACT ON FACULTY RESEARCH SUPPORT AND PROFESSIONAL DEVELOPMENT, STUDENT TRAINING OPPORTUNITIES, INSTITUTIONAL RESEARCH CULTURE, AND RESEARCH INFRASTRUCTURE.

INDUCING APOPTOSIS IN CASTRATION- RESISTANT PROSTATE CANCER BY TARGETING SPHINGOMYELIN SYNTHASE 1 FOR MONO AND COMBINATION THERAPY - PROJECT SUMMARY IN AGING MEN ≥ 65 YEARS, PROSTATE CANCER (PC) IS THE MOST COMMON CANCER ESPECIALLY FOR TREATMENT EVADING RESISTANT VARIANTS. THE GOAL OF THIS PROJECT IS TO DEVELOP CERAMIDE MIMICS BASED SPHINGOMYELIN SYNTHASE 1 (SMS1) INHIBITORS FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER (CRPC) BY PREVENTING CERAMIDE (CER) METABOLISM. UPREGULATION OF CERAMIDE-METABOLIZING ENZYMES, INCLUDED WITH CONCOMITANT REDUCTION IN CELLULAR CERAMIDE LEVELS, IS OBSERVED IN AGGRESSIVE CANCERS, INCLUDING CRPC. THIS ACTIVITY IS ALSO ASSOCIATED WITH INCREASED RESISTANCE TO APOPTOSIS AND WITH BIOSYNTHESIS OF SECONDARY METABOLITES THAT PROMOTE CELL SURVIVAL. STRATEGIES THAT INCREASE CERAMIDE THUS HOLD POTENTIAL FOR TREATMENT OF REFRACTORY CANCERS. TARGETING CERAMIDE METABOLISM IN-CONJUNCTION WITH FDA APPROVED PHARMACOLOGICAL INTERVENTIONS HAS PROMISE IN TREATING CRPC. CERAMIDE MIMIC - JASPINE B, A NATURALLY-OCCURRING CERAMIDE MIMIC, INHIBITS SPHINGOMYELIN SYNTHASE (SMS) - A KEY CERAMIDE-METABOLIZING ENZYME. IN A TEAM EFFORT, OUR LABORATORY IDENTIFIED JASPINE B EXHIBITED DOSE-DEPENDENT CYTOTOXICITY AGAINST MELANOMA AND SARCOMA CELLS IN CULTURE THAT WAS ASSOCIATED WITH INCREASED CASPASE-3/7 ACTIVITY. JASPINE B ALSO DISPLAYED MARKED THERAPEUTIC EFFICACY IN OUR IN VIVO SYNOVIAL SARCOMA MODEL. THESE STRONG PRELIMINARY DATA SUPPORT A MEDICINAL CHEMISTRY PROGRAM TO IMPROVE THE DRUG-LIKE PROPERTIES OF MOLECULES. THE EFFICACY OF JASPINE B IN CRPC WILL BE VALIDATED IN TWO WELL CHARACTERIZED PROSTATE CANCER CELL LINES AND IN A RELEVANT PATIENT-DERIVED XENOGRAPH (PDX) MOUSE MODEL. THE GOALS OF THE PROPOSED RESEARCH ARE TO: 1) EVALUATE THE EFFICACY OF SMS1 INHIBITION BY JASPINE B IN CRPC. 2) IMPROVE JASPINE B- MEDIATED SMS1 INHIBITION THROUGH ANALOG SYNTHESIS AND/OR COMBINATION THERAPY. 3) DELINEATE THE POSSIBLE MECHANISMS OF RESISTANCE OF SMS1 INHIBITION. THE COMPLETION OF THE PROJECT WILL IDENTIFY A LEAD MOLECULE BASED ON JASPINE B CORE TARGETING SMS1 IN CRPC, IDENTIFY A PROBE TO INTERROGATE CERAMIDE FLUX. THE MAJOR INNOVATION OF THIS PROJECT IS THE THERAPEUTIC DEVELOPMENT OF SPHINGOLIPID MEMBRANE BIOCHEMISTRY USING THE CERAMIDE MIMIC JASPINE B CORE. WE AIM TO SHOW THE SIGNIFICANCE OF SPHINGOLIPIDS IN COMBINATION THERAPY WITH FDA APPROVED ANTICANCER AGENTS. THIS PROJECT WILL HAVE A SIGNIFICANT IMPACT ON UNDERGRADUATE AND GRADUATE STUDENT TRAINING AT IDAHO STATE UNIVERSITY.

REDOX INTERACTIONS OF CYTOCHROMES AND BACTERIA WITH OXIDE SURFACES: PROBING REDOX LINKED CONFORMATIONAL CHANGE