Jackson

US MILITARY HIV RESEARCH

ADDRESSING THE THREATS OF HIV AND EMERGING INFECTIOUS DISEASE TO THE MILITARY AND GLOBAL COMMUNITY THROUGH INNOVATIVE RESEARCH

US MILITARY HUMAN IMMONODEFIECIENCY VIRUS (HIV) RESEARCH PROGRAM

HIV PROGRAM FOR PRESIDENTS EMERGENCY PLAN FOR AIDS RELIEF PEPFAR AWARD

RECIPIENT PROVIDES EXPERT, INNOVATIVE, AND RESPONSIVE OPERATIONAL SUPPORT OF DPAA EFFORTS TO LOCATE,RECOVER, AND IDENTIFY THE REMAINS OF UNACCOUNTED FOR DEPARTMENT OF DEFENSE DOD PERSONNEL FROM DESIGNATED PAST CONFLICTS. DPAA MISSION INVOLVES HISTORICAL RESEARCH, ARCHAEOLOGY,FORENSIC ANTHROPOLOGY,LABORATORY ANALYSES,AND OTHER RELATED ACTIVITIES

CENTER FOR NEUROSCIENCE AND REGENERATIVE MEDICINE CNRM

ESTABLISHMENT OF THE COLLABORATIVE HEALTH INITIATIVE RESEARCH PROGRAM (CHIRP)

U.S. MILITARY HUMAN IMMUNODEFICIENCY VIRUS (HIV) RESEARCH PROGRAM

PA-22 & PA-20

RESEARCH AND DEVELOPMENT OF PROTECTIVE VACCINES AND OTHER COUNTERMEASURES AGAINST INFECTIOUS DISEASE AGENTS OF MILITARY IMPORTANCE AWARD

NATURAL HISTORY STUDY CLINICAL CORRELATES OF TRAUMATIC BRAIN INJURY

HIGHER EDUCATION EMERGENCY RELIEF FUND

INFECTIOUS DISEASE CLINICAL RESEARCH PROGRAM (IDCRP)

NATIONAL EMERGENCY MEDICAL SERVICES & 911 PROJECTS TO SUPPORT POST-CRASH CARE

INFECTIOUS DIEASE CLINICAL RESEARCH PROGRAM

MODIFIABLE RISK AND PROTECTIVE FACTORS FOR SUICIDAL BEHAVIORS IN THE US ARMY

HIV EMERGENCY RELIEF PROJECT GRANTS

GYNECOLOGICAL CANCER TRANSLATIONAL RESEARCH CENTER OF EXCELLENCE

CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND - INSTITUTIONAL ALLOCATION

MURTHA CANCER CENTER TRANSLATIONAL CLINICAL RESEARCH: APPLIED PROTEOGENOMICS ORGANIZATIONAL LEARNING AND OUTCOMES (APOLLO)AND FRAMINGHAM CORE

THIS IS A FFY 2021 AMERICAN RESCUE PLAN (ARP) ACT 5307 URBANIZED AREA FORMULA GRANT PROGRAM APPLICATION IN THE AMOUNT OF $ 57957622. THE APPLICATION IS FOR PAYROLL ADMINISTRATIVE AND OPERATING EXPENSES DUE TO REDUCTIONS IN SERVICE OR QUARANTINE AT THE JACKSONVILLE TRANSPORTATION AUTHORITY IN DUVAL COUNTY JACKSONVILLE FLORIDA. THIS INCLUDES PERSONNEL FOR MASS TRANSIT OPERATIONS CTC OPERATIONS FERRY OPERATIONS AND SKYWAY OPERATIONS. THIS IS ONE SOLE APPLICATION THAT THE JACKSONVILLE TRANSPORTATION AUTHORITY WILL SUBMIT TO UTILIZE THE ARPA FUNDING.ON MARCH 11 2021 THE AMERICAN RESCUE PLAN (ARP) ACT OF 2021 WHICH INCLUDES $30.46 BILLION IN TRANSIT FUNDING WAS SIGNED INTO LAW.THIS APPLICATION INCLUDES ELIGIBLE COSTS BEGINNING ON JANUARY 13 2021 THROUGH JANUARY 6 2022.THIS APPLICATION INCLUDES ELIGIBLE COSTS BEGINNING ON JANUARY 13 2021 THROUGH APRIL 29 2021 (ACTUAL $18531736)THIS APPLICATION INCLUDES ELIGIBLE COSTS BEGINNING ON MAY 5 2021 THROUGH SEPTEMBER 30 2021. (PROJECTED $27301218)THIS APPLICATION INCLUDES ELIGIBLE COSTS BEGINNING ON OCTOBER 1 2021 THROUGH JANUARY 6 2022. (PROJECTED $12124668).OPERATING FUNDS WILL COVER EXPENSES FROM JANUARY 13 2021 THROUGH JANUARY 6 2022 INCLUDING EARNINGS EMPLOYER BENEFITS LIABILITIES WITH PENSION AND TAXES. 1% SECURITY EXPENDITURES IS ACCOUNTED FOR IN THIS GRANT APPLICATION COVERING SECURITY PERSONNEL. THIS CALCULATION IS $579576 IS INCLUDED IN ALI 30.09.08. SEE ATTACHMENT - 1% PERIOD ACTUAL FOR JANUARY 13 2021 THROUGH APRIL 29 2021. ($185317)SEE ATTACHMENT - 1% PERIOD PROJECTED FOR MAY 5 2021 THROUGH SEPTEMBER 30 2021. ($273012)SEE ATTACHMENT - 1% PERIOD PROJECTED FOR OCTOBER 1 2021 THROUGH JANUARY 6 2022. ($121247)THE FEDERAL SHARE OF THIS APPLICATION IS 100%.THE RECIPIENT AGREES THAT IF IT RECEIVES FEDERAL FUNDING FROM THE FEDERAL EMERGENCY MANAGEMENT AGENCY (FEMA) OR THROUGH A PASS-THROUGH ENTITY THROUGH THE ROBERT T. STAFFORD DISASTER RELIEF AND EMERGENCY ASSISTANCE ACT A DIFFERENT FEDERAL AGENCY OR INSURANCE PROCEEDS FOR ANY PORTION OF A PROJECT ACTIVITY APPROVED FOR FTA FUNDING UNDER THIS GRANT AGREEMENT IT WILL PROVIDE WRITTEN NOTIFICATION TO FTA AND REIMBURSE FTA FOR ANY FEDERAL SHARE THAT DUPLICATES FUNDING PROVIDED BY FEMA ANOTHER FEDERAL AGENCY OR AN INSURANCE COMPANY.THE OPERATING EXPENSES REQUESTED IN THIS APPLICATION WERE DETERMINED BY THE JACKSONVILLE TRANSPORTATION AUTHORITY. THE JACKSONVILLE TRANSPORTATION AUTHORITY UNDERSTANDS THAT THE EXPENSES REQUESTED IN THIS APPLICATION ARE SUBJECT TO REVIEW FOR THEIR REASONABLENESS AS PART OF THE AGENCYS NEXT TRIENNIAL/STATE MANAGEMENT REVIEW.AN INSURANCE CLAIM HAS NOT BEEN FILED. INSURANCE IS NON-APPLICABLE FOR THIS PROJECT.THE JACKSONVILLE TRANSPORTATION AUTHORITY IS A DESIGNATED RECIPIENT OF SECTION 5037 URBANIZED AREA FORMULA ARPA FUNDS.THE JACKSONVILLE TRANSPORTATION AUTHORITY WILL FOLLOW ALL 3RD PARTY PROCUREMENT POLICIES AS DEFINED IN C4220.1F (THIRD PARTY CONTRACTING GUIDANCE).THE JACKSONVILLE TRANSPORTATION AUTHORITY WILL ENSURE CONTRACTORS PROCURED WILL NOT BE ON THE FTA SUSPENSION AND DEBARMENT LIST.THIS PROJECT ONLY INCLUDES PAYROLL ADMINISTRATIVE AND OPERATING EXPENSES THAT DO NOT INCLUDE SUBSTANTIAL FUNCTIONAL LOCATION OR CAPACITY CHANGES TO THE ASSET OR SYSTEM. THEREFORE NO ADDITIONAL TIP/STIP DOCUMENTATION IS NEEDED.

CREST-2 CLINICAL COORDINATING CENTER

UNIFORMED SERVICES UNIVERSITY (USU) AND UNIVERSITY OF CALIFORNIA SAN FRANCISCO (UCSF) PARTNERSHIP FOR DEVELOPMENT OF CHRONIC TRAUMATIC ENCEPHALOPATHY (CTE) THERAPEUTICS

COOPERATIVE AGREEMENT WITH THE KENYA MEDICAL RESEARCH INSTITUTE (KEMRI)

UNIFORMED SERVICES UNIVERSITY (USU) AND UNIVERSITY OF CALIFORNIA SAN FRANCISCO (UCSF) PARTNERSHIP FOR DEVELOPMENT OF CHRONIC TRAUMATIC ENCEPHALOPATHY (CTE) THERAPEUTICS

COMPREHENSIVE REPRODUCTIVE SYSTEM CARE PROGRAM-CLINICAL BREAST CARE PROJECT (CRSCP-CBCP)

HISTORICALLY BLACK COLLEGES AND UNIVERSITIES PROGRAM

KEMRI/CDC PROGRAM (RESEARCH)

THE JACKSON LABORATORY KNOCKOUT MOUSE PRODUCTION AND PHENOTYPING PROJECT (JAX KOMP2)

HIV EMERGENCY RELIEF PROJECT GRANTS

MOUSE GENOME DATABASE

BASE AWARD FOR AUSTERE ENVIRONMENTS CONSORTIUM FOR ENHANCE SEPSIS OUTCOMES (ACESO) AWARD

SURGICAL CRITICAL CARE INITIATIVE (SC2I) BIOLOGY DRIVEN CRITICAL CARE

MURTHA CANCER CENTER TRANSLATIONAL RESEARCH PROGRAM

CENTER FOR PROSTATE DISEASE RESEARCH CPDR

CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND

CANCER CENTER SUPPORT (CORE) GRANT

UCSF/USUHS PARTNERSHIP TO DEVELOP TAU PRION THERAPEUTICS FOR CHRONIC TRAUMATIC ENCEPHALOPATHY

BIOLOGY AND PATHOBIOLOGY OF APOE IN AGING AND ALZHEIMER'S DISEASE - PROJECT SUMMARY (APOE U19: OVERALL) THE OVERARCHING GOAL OF THIS U19 PROJECT IS TO COMPREHENSIVELY UNDERSTAND THE BIOLOGY AND PATHOBIOLOGY OF APOLIPOPROTEIN E (APOE) IN AGING AND ALZHEIMER’S DISEASE (AD) TO INFORM THERAPEUTIC STRATEGIES. THE E4 ALLELE OF THE APOE GENE (APOE4) IS THE STRONGEST GENETIC RISK FACTOR FOR AD IMPACTING 50-70% OF ALL AD PATIENTS, WHILE THE E2 ALLELE IS PROTECTIVE COMPARED TO THE COMMON E3 ALLELE. APOE4 IS ALSO A STRONG RISK FACTOR FOR AGE-RELATED COGNITIVE DECLINE AND VASCULAR COGNITIVE IMPAIRMENT. TO INTEGRATE EXISTING KNOWLEDGE AND ADDRESS CRITICAL GAPS, WE PROPOSE A UNIFIED APOE CASCADE HYPOTHESIS THAT THE STRUCTURAL DIFFERENCES AND RELATED BIOCHEMICAL PROPERTIES AMONG THE THREE APOE ISOFORMS INITIATE THEIR DIFFERENTIAL EFFECTS ON A CASCADE OF EVENTS AT THE CELLULAR AND SYSTEMS LEVELS ULTIMATELY IMPACTING AGING-RELATED PATHOGENIC CONDITIONS INCLUDING AD. TOWARDS THIS, WE HAVE ASSEMBLED A MULTI-DISCIPLINARY TEAM TO SYNERGIZE EXPERTISE AND RESOURCES ACROSS MULTIPLE INSTITUTIONS. BY INTEGRATING FIVE INTERACTIVE PROJECTS AND SEVEN ROBUST CORES, WE WILL CREATE A NEXUS FOR APOE-RELATED AGING RESEARCH, SHARING THE KNOWLEDGE, EXPERTISE AND RESOURCES WITH THE BROADER SCIENTIFIC COMMUNITY. PROJECT 1 WILL WORK CLOSELY WITH CORE B TO ADDRESS THE STRUCTURAL AND BIOCHEMICAL PROPERTIES OF THE THREE APOE ISOFORMS TO GENERATE INSIGHTS FOR FUNCTIONAL OUTCOMES. PROJECTS 2, 3 AND 4 WILL INTERACTIVELY STUDY HOW APOE ISOFORMS EXPRESSED IN ASTROCYTES, MICROGLIA, OR VASCULAR MURAL CELLS IMPACT LIPID METABOLISM, GLIAL AND VASCULAR FUNCTIONS, AD-RELATED PATHOLOGIES, AND CELLULAR AND MOLECULAR PATHWAYS USING CONDITIONAL MOUSE MODELS AND SYSTEMS- BASED APPROACHES. THESE STUDIES WILL GENERATE CELL TYPE-SPECIFIC APOE/LIPOPROTEIN PARTICLES THAT WILL BE COLLECTED THROUGH IN VIVO MICRODIALYSIS FOR STRUCTURAL AND BIOCHEMICAL STUDIES. PROJECT 5 WILL CARRY OUT GENOMIC AND GENETIC ANALYSES TO IDENTIFY MODIFIERS OF APOE-RELATED AGE AT ONSET OF AD. STUDIES IN PROJECTS 2-5 WILL BE INTERACTIVELY SUPPLEMENTED BY NEUROPATHOLOGICAL STUDIES USING POSTMORTEM BRAINS FROM HEALTHY AGING STUDIES OR WITH AD PATHOLOGIES (CORE C), BIOMARKER STUDIES USING BOTH HUMAN AND MOUSE BIOSPECIMENS (CORE D), AND FUNCTIONAL STUDIES USING HUMAN IPSC-DERIVED CELLULAR AND ORGANOID MODELS (CORE E). THIS U19 PROPOSAL IS SUPPORTED BY A COMPREHENSIVE MULTI-OMICS CORE (CORE F) FOR CENTRALIZED PROTEOMICS, LIPIDOMICS, AND METABOLOMICS STUDIES ON VARIOUS ANIMAL AND IPSC MODELS, AS WELL AS HUMAN POSTMORTEM BRAINS AND FLUID BIOSPECIMENS. THE BIOINFORMATICS, BIOSTATISTICS, AND DATA MANAGEMENT CORE (CORE G) WILL PROVIDE CRITICAL SUPPORTS FOR ANALYZING LARGE DATASETS INCLUDING THOSE FROM SINGLE-CELL RNA-SEQ AND BIOSTATISTICS SUPPORTS TO ENSURE SCIENTIFIC RIGOR. CORE G WILL ALSO WORK CLOSELY WITH THE ADMINISTRATIVE CORE (CORE A) TO MAINTAIN AN APOE WEB PORTAL DESIGNATED AS EPAAD WHERE KNOWLEDGE, RESOURCES, AND DATA WILL BE SHARED WITH THE SCIENTIFIC COMMUNITY. CORE A WILL ALSO ORGANIZE ANNUAL APOE SYMPOSIUM TO PROMOTE COLLABORATION AND ENGAGE THE APOE COMMUNITY. AS SUCH, THIS U19 WILL DRIVE A TEAM-BASED EFFORT TO GENERATE ESSENTIAL KNOWLEDGE TO GUIDE DISEASE- MODIFYING THERAPIES FOR AD AND OTHER AGING-RELATED CONDITIONS.

COOPERATIVE AGREEMENT FOR PROJECT ENTITLED: AUSTERE ENVIRONMENT CONSORTIUM FOR ENHANCED SEPSIS OUTCOMES (ACESO) AWARD.

BREAST CANCER TRANSLATIONAL RESEARCH CENTER OF EXCELLENCE

GYNECOLOGIC CANCER CENTER OF EXCELLENCE (GYN-COE)

PURPOSE: SHIFT TAXIWAY; EXPAND APRON. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT EXPANDS EXISTING CONCOURSE B APRON AN ADDITIONAL 28,944 SQUARE YARDS TO ACCOMMODATE MORE PASSENGERS AND ACCOMMODATE AIRCRAFT OPERATIONS. THIS PROJECT SHIFTS EXISTING PAVED TAXIWAY W BY 600 FEET TO BRING THE AIRPORT INTO CONFORMITY WITH CURRENT STANDARDS. THIS GRANT FUNDS PHASE 1, WHICH CONSISTS OF DESIGN AND THE FIRST PHASE OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH JACKSONVILLE, FLORIDA.

GENE EXPRESSION DATABASE FOR MOUSE DEVELOPMENT

UCSF/USUHS PARTNERSHIP TO DEVELOP TAU PRION THERAPEUTICS FOR CHRONIC TRAUMATIC ENCEPHALOPATHY

CENTRALLY-LINKED LONGITUDINAL PERIPHERAL BIOMARKERS OF AD IN MULTI-ETHNIC POPULATIONS - SUMMARY ABSTRACT (30 LINES): EXISTING CEREBROSPINAL FLUID (CSF) AND NEUROIMAGING MEASURES OF AMYLOID SS, TAU AND NEURODEGENERATION (A,T,N) SERVE AS USEFUL DIAGNOSTIC BIOMARKERS FOR ALZHEIMER’S DISEASE (AD), HOWEVER THERE REMAINS AN URGENT, UNMET NEED FOR BLOOD BASED BIOMARKERS IN AD. FIRST, MULTI-OMIC STUDIES DISCOVERED MANY PERTURBED BIOLOGICAL PATHWAYS IN AD, HOWEVER, SYSTEMATIC STUDIES FOR BIOMARKERS THAT CAPTURE THESE DIVERSE BIOLOGICAL FACETS OF AD ARE LIMITED. SECOND, AD IS A HETEROGENEOUS DISORDER BUT BIOMARKERS THAT CAN DISTINGUISH THE BIOLOGICAL SUBTYPES OF AD ARE LACKING. THIRD, CORE AD NEUROPATHOLOGY OFTEN CO-EXISTS WITH OTHER NEUROPATHOLOGIES SUCH AS VASCULAR DISEASE (V). THESE CO-MORBIDITIES AND CO-PATHOLOGIES NEED TO BE CONSIDERED IN BIOMARKER DISCOVERY. FOURTH, EXISTING BIOMARKER STUDIES ARE HEAVILY FOCUSED ON NON-HISPANIC WHITES (NHW). SIMILAR STUDIES IN UNDERREPRESENTED POPULATIONS (URP) ARE NEEDED. THIS U19, BRINGING TOGETHER >40 EXPERTS ACROSS 13 INSTITUTIONS, AIMS TO BRIDGE THESE KNOWLEDGE GAPS FOR DISCOVERY AND VALIDATION OF CENTRALLY-LINKED LONGITUDINAL PERIPHERAL BIOMARKERS OF AD (CLEAR-AD) IN MULTI-ETHNIC POPULATIONS. CLEAR-AD U19 IS BASED ON THE PREMISE THAT AD IS A COMPLEX DISORDER IN WHICH MANY BIOLOGICAL PATHWAYS ARE DISRUPTED DUE TO MULTI-OMIC PERTURBATIONS, WHICH CAN BE DETECTED IN BRAIN AND REFLECTED IN BLOOD, I.E. CENTRALLY-LINKED PERIPHERAL MOLECULAR SIGNATURES (CLPMS). THE SPECIFIC AIMS OF CLEAR-AD U19 ARE: 1) TO DISCOVER CLPMS OF THE COMPLEX AND HETEROGENEOUS AD PATHOPHYSIOLOGY AND ITS CO-PATHOLOGIES. 2) TO IDENTIFY LONGITUDINAL CLPMS THAT DETECT AND PREDICT DYNAMIC NEUROIMAGING, FLUID BIOMARKER, AND CLINICAL CHANGES ACROSS AD SPECTRUM. 3) TO CHARACTERIZE DIFFERENCES AND SIMILARITIES IN CLPMS PROFILES ACROSS NHW, AFRICAN AMERICAN (AA) AND LATINO AMERICAN (LA) PARTICIPANTS TO UNCOVER BIOMARKER PATTERNS IN MULTI-ETHNIC GROUPS. 4) TO MAKE THESE VAST RESOURCES AVAILABLE TO THE SCIENTIFIC COMMUNITY TO AMPLIFY AND ACCELERATE ITS IMPACT. IN THIS U19 MANAGED BY THE ADMINISTRATIVE CORE, WE WILL LEVERAGE NIH-FUNDED ADNI, MCSA AND ADRC COHORTS OF >3,700 MULTI-ETHNIC PARTICIPANTS TO GENERATE >20,000 MULTI-OMICS MEASURES (OMICS CORE) THAT WILL BE PROCESSED AND INTEGRATED WITH >48,000 HARMONIZED AD COGNITIVE, NEUROIMAGING AND FLUID ENDOPHENOTYPES (ANALYTIC CORE). USING THESE DATA, WE WILL IDENTIFY BRAIN REGION AND CELL-TYPE SPECIFIC CLPMS, WHICH REFLECT BIOLOGICAL SUBTYPES OF AD AND DISEASE STAGE (PROJECT 1). WE WILL DISCOVER LONGITUDINAL CHANGES IN CLPMS THAT PREDICT COGNITIVE AND A/T/N/V PROGRESSION (PROJECT 2). WE WILL DEFINE LONGITUDINAL COGNITIVE AND A/T/N/V CHANGES AND CLPMS IN URP THAT ARE EITHER CONSERVED WITH NHW OR POPULATION-SPECIFIC (PROJECT 3). THIS U19 WILL A) IDENTIFY THE NEXT GENERATION OF AD BIOMARKERS WITH MECHANISTIC INSIGHTS; B) ESTABLISH A PRECISION MEDICINE APPROACH FOR RIGOROUS MULTI-OMICS BIOMARKER DISCOVERY AND VALIDATION IN AD; C) DISCOVER MOLECULES THAT CAN SERVE AS BIOMARKERS AND THERAPEUTIC TARGETS; D) ENHANCE BIOMARKER RESEARCH IN TRIAL-READY MULTI-ETHNIC POPULATIONS; AND E) GENERATE AND SHARE A VAST AND HARMONIZED RESOURCE OF ENDOPHENOTYPE AND MULTI-OMICS DATA IN NIH-FUNDED COHORTS.

FY 2021 CRRSAA SECTION 5307 OPERATING COSTS JTA JACKSONVILLE FLORIDA

DEFENSE GRADUATE PSYCHOLOGY EDUCATION PROGRAM

MURTHA CANCER TRANSLATIONAL CLINICAL RESEARCH: APPLIED PROTEOGENOMICS ORGANIZATIONAL LEARNING AND OUTCOMES (APOLLO) AND FRAMINGHAM - FY24 CORE

UNKNOWN TITLE

CENTER FOR DEFENSE PSYCHOLOGY (CDP)

MILITARY TRAUMATIC BRAIN INJURY (MTBI-2) INITIATIVE - RESEARCH COLLABORATION

BIOSCIENCES TECHNOLOGY SUPPORT (BTS) IN ACCORDANCE WITH RECIPIENT PROPOSAL DATED 4 AUGUST 2005.

BREAST CANCER OF EXCELLENCE (BC-COE) CLINICAL BREAST CARE PROJECT (CBCP)

BRAIN INJURY AND DISEASE PREVENTION, TREATMENT, AND RESEARCH - FY CORE

US MINILARY HUMAN IMMUNODEFICIENCY VIRUS (HIV) RESEARCH PROGRAM

WOUNDED WARRIOR SERVICE DOG PROGRAM WWSDP

STUDY TO ASSESS SUICIDE RISK AND RESILIENCE IN SERVICE MEMBER (STARRS)

BREAST CANCER OF EXCELLENCE (BREAST-COE) CORE

RED HILL WATER REGISTRY

POTTER G11220-01

INTERVENTIONS THAT RETARD MAMMALIAN AGING

IMPROVE EXISTING AIRPORT

HBCU - INSTITUTIONAL AID

GYNECOLOGIC CANCER - CENTER OF EXCELLENCE (GYN-COE)

MURTHA CANCER CENTER INFRASTRUCTURE SUPPORT

NEIGHBORHOOD STABILIZATION PRG

LEVERAGING TRAUMA CRITICAL CARE RESEARCH FOR THE DEVELOPMENT OF CLINICAL DECISION SUPPORT TOOLS IN SUPPORT OF THE SURGICAL CRITICAL CARE INITIATIVE (SC2I)

BRAIN INJURY AND DISEASE PREVENTION, TREATMENT, AND RESEARCH CORE

APPLICATION PURPOSE: THIS MULTI-SOURCE GRANT (OR SUPER GRANT) WILL PROVIDE REPLACEMENT OF PARATRANSIT VEHICLES FOR DEMAND RESPONSE USE HVAC REPLACEMENTS REPLACEMENT 40 FOOT BUSES INSPECTION OF NEW BUSES SHOP EQUIPMENT ALONG WITH THE BUS STOP AND BUS SHELTER IMPROVEMENTS IT TECHNOLOGY PURCHASES IMPLEMENTATION OF SAFETY AND SECURITY MEASURES FERRY TURNING DOLPHINS LONG- AND SHORT-RANGE PLANNING ACTIVITIES AND PREVENTATIVE MAINTENANCE FOR THE JACKSONVILLE TRANSPORTATION AUTHORITY. EACH FORMULA GRANT APPORTIONMENT IS INCLUDED IN THIS MULTI-SOURCE GRANT AS A PROJECT.; ACTIVITIES PERFORMED: FUNDING UNDER S. 5307 URBANIZED AREA FORMULA GRANT (PROJECT 4). THE S. 5307 URBANIZED AREA FORMULA GRANT WILL FUND SUPPORT VEHICLE REPLACEMENT ELEVATOR UPGRADES HVAC REPLACEMENT IT TECHNOLOGY NETWORK HARDWARE SHOP EQUIPMENT 5G ROUTERS COMPUTER HARDWARE REPLACEMENT OF 40-FOOT BUSES REPLACEMENT OF PARATRANSIT VEHICLES AND UPWP PLANNING TASKS. FUNDING UNDER S. 5337 URBANIZED AREA FORMULA GRANT (PROJECT 2) WILL PROVIDE FOR STATION RENOVATIONS AND UPGRADES FOR THE SKYWAY. FUNDING UNDER S. 5339 URBANIZED AREA FORMULA GRANT (PROJECT 3) WILL PROVIDE FUNDING FOR REPLACEMENT OF PARATRANSIT VEHICLES (10 MINIBUSES) AND A/C SHOP EQUIPMENT FOR THE SERVICING OF THE PARATRANSIT VEHICLES AND A TWO POST VEHICLE LIFT FOR THE SERVICING OF THE PARATRANSIT VEHICLES. FUNDING UNDER S. 5307 CAPITAL ADA PARATRANSIT GRANT (PROJECT 1) IS FOR CTC OPERATIONS FOR UP TO 10 PERCENT OF THE ANNUAL FORMULA APPORTIONMENT FOR ADA PARATRANSIT.; EXPECTED OUTCOMES: THIS FUNDING WILL AID THE JACKSONVILLE TRANSPORTATION AUTHORITY IN CONTINUING TO PROVIDE SAFE RELIABLE EFFICIENT AND SUSTAINABLE MULTI-MODAL TRANSPORTATION SERVICES AND FACILITIES.; INTENDED BENEFICIARIES: OUR CUSTOMERS AND COMMUNITY PARTNERS WITHIN THE JACKSONVILLE URBANIZED AREA AND OUR REGIONAL PARTNERSHIPS.; SUBRECIPIENT ACTIVITIES: NONE

IMPROVE EXISTING AIRPORT

DEVELOPMENT OF A MULTISTAGE MULTIANTIGEN VACCINE AGAINST MALARIA

APPLICATION PURPOSE: THIS MULTI-SOURCE GRANT (OR SUPER GRANT) WILL PROVIDE REPLACEMENT 35-FOOT CNG BUSES REPLACEMENT PARATRANSIT VANS SHOP EQUIPMENT ALONG WITH THE BUS STOP AND BUS SHELTER IMPROVEMENTS IT TECHNOLOGY PURCHASES IMPLEMENTATION OF SAFETY AND SECURITY MEASURES AND LONG- AND SHORT-RANGE PLANNING ACTIVITIES FOR THE JACKSONVILLE TRANSPORTATION AUTHORITY. EACH FORMULA GRANT APPORTIONMENT IS INCLUDED IN THIS MULTI-SOURCE GRANT AS A PROJECT.; ACTIVITIES PERFORMED: FUNDING UNDER S. 5307 URBANIZED AREA FORMULA GRANT (PROJECT 2). THE S. 5307 URBANIZED AREA FORMULA GRANT WILL FUND THE CCTV FOR SAFETY AND SECURITY SAFETY AND SECURITY ACCESS SYSTEMS UPGRADE ACROSS ALL JTA CAMPUSES CNG BUS PURCHASES AND THE ASSOCIATED TRAINING/INSPECTIONS CTC REPLACEMENT VEHICLES ELEVATOR UPGRADES ESCALATOR MODERNIZATION PLATFORM SIGNAGE HVAC REPLACEMENT BUS TRAINING SIMULATOR RAILING REPLACEMENT ENTERPRISE ASSET MANAGEMENT OVERLAY FERRY (PHASE V) IMPROVEMENTS HUMAN RESOURCE MANAGEMENT SYSTEM IT TECHNOLOGY NETWORK HARDWARE BUS STOP SHELTER SITEWORK AND AMENITIES SHOP EQUIPMENT RIDE-ON SWEEPERS LIFTS COMPUTER HARDWARE AND UPWP PLANNING TASKS. FUNDING UNDER S. 5337 URBANIZED AREA FORMULA GRANT (PROJECT 4) WILL PROVIDE FOR STATION IMPROVEMENTS FOR THE SKYWAY. FUNDING UNDER S. 5339 URBANIZED AREA FORMULA GRANT (PROJECT 3) WILL PROVIDE FUNDING FOR EXPANSION OF DEMAND RESPONSE VEHICLE FOR IN-HOUSING OF READI-RIDE AND CONNEXION PLUS - 11 VEHICLES.; EXPECTED OUTCOMES: THIS FUNDING WILL AID THE JACKSONVILLE TRANSPORTATION AUTHORITY IN CONTINUING TO PROVIDE SAFE RELIABLE EFFICIENT AND SUSTAINABLE MULTI-MODAL TRANSPORTATION SERVICES AND FACILITIES.; INTENDED BENEFICIARIES: OUR CUSTOMERS AND COMMUNITY PARTNERS WITHIN THE JACKSONVILLE URBANIZED AREA AND OUR REGIONAL PARTNERSHIPS.; SUBRECIPIENT ACTIVITIES: NONE

GENOME DYNAMICS: EVOLUTION, ORGANIZATION AND FUNCTION

HIGHER EDUCATION EMERGENCY RELIEF FUND-INSTITUTIONAL PORTION

PRESERVATIONOF THE FORCE AND FAMILY (POTFF) BEHAVIORAL HEALTH PROGRAM.

ADVANCEMENT OF VACCINES AND THERAPIES FOR HENIPAVIRUSES

A SYSTEM APPROACH TO TARGETING INNATE IMMUNITY IN AD

PURPOSE: AMERICAN RESCUE PLAN ACT AWARDED AS ECONOMIC ASSISTANCE TO ELIGIBLE U.S. AIRPORTS AND ELIGIBLE CONCESSIONS AT THOSE AIRPORTS TO PREVENT, PREPARE FOR, AND RESPOND TO THE COVID-19 PANDEMIC. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS GRANT PROVIDES ECONOMIC RELIEF FUNDS FOR COSTS RELATED TO OPERATIONS, PERSONNEL, CLEANING, SANITIZATION, JANITORIAL SERVICES, DEBT SERVICE PAYMENTS, AND COMBATING THE SPREAD OF PATHOGENS AT THE AIRPORT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH JACKSONVILLE, FLORIDA.

PROSTATE DISEASE RESEARCH

CENTER FOR THE STUDY OF TRAUMATIC STRESS (CSTS) PROGRAM

NATIONAL CENTER FOR DISASTER MEDICINE AND PUBLIC HEALTH (NCDMPH) NATIONAL DISASTER MEDICAL SYSTEM PILOT PHASE IV

CANCER MOONSHOT 2

CENTER FOR SYSTEMS NEUROGENETICS OF ADDICTION

AWARD PURPOSE EXPRESS - EXEMPLIFYING POTENTIAL TO REDUCE EMISSIONS WITH SUSTAINABLE SOLUTIONS PROJECT ACTIVITIES TO BE PERFORMED THE PROJECT INCLUDES FIVE PRIMARY COMPONENTS 1 INSTALLATION OF ELECTRIFIED REFRIGERATED CONTAINER STACKS 2 PROCUREMENT OF SIX HYBRID ELECTRIC RUBBER TIRED GANTRY CRANES 3 PROCUREMENT OF 16 BATTERY ELECTRIC FORKLIFTS TEN BATTERY ELECTRIC YARD TRACTORS AND SEVEN TIER 4 DIESEL TOP PICKS 4 INSTALLATION OF 15 HIGH POWER DIRECT CURRENT FAST CHARGING STATIONS AND MAKE READY STUB OUTS AND 5 DEVELOPMENT OF A REPLACEABLE AND SCALABLE PLAN FOR TRANSITIONING THE PORT AND LOCAL MARITIME INDUSTRY TO ZERO EMISSION TECHNOLOGIES. DELIVERABLES EXPECTED OUTCOMES WITHIN FREIGHT MOVEMENT MEASURE UMBER OF TEU RAILCAR TRUCK MOVEMENTS MEASURED QUARTERLY. WITHIN CARGO LIFTS MEASURE CARGO LIFTS PERFORMED MEASURED QUARTERLY. WITHIN GREENHOUSE GAS EMISSIONS TOTAL CALCULATED GHG EMISSIONS CARBON MONOXIDE AND PARTICULATE MATTER MEASURED ANNUALLY. INTENDED BENEFICIARY JACKSONVILLE PORT AUTHORITY. SUBRECIPIENTS NONE.

AGREEMENT ORDER FA8650-10-2-6A02 IS HEREBY ESTABLISHED FOR THE "BIOSCIENCE RESEARCH FOR RHPB" EFFORT. THIS IS AGREEMENT ORDER 2 AGAINST BASIC COOPER

CENTER FOR NEUROSCIENCE AND REGENERATIVE MEDICINE (CNRM)

PILOT BROADBAND GRANT

COMBAT AND TRAINING QUERYABLE EXPOSURE EVENT REPOSITORY (CONQUER)-2

AIRMAN READINESS MEDICAL RESEARCH (ARMR) PROGRAM

APPLICATION PURPOSE: THIS MULTI-SOURCE GRANT (OR SUPER GRANT) WILL PROVIDE REPLACEMENT 35-FOOT CNG BUSES REPLACEMENT PARATRANSIT VANS SHOP EQUIPMENT ALONG WITH THE BUS STOP AND BUS SHELTER IMPROVEMENTS IT TECHNOLOGY PURCHASES IMPLEMENTATION OF SAFETY AND SECURITY MEASURES AND LONG- AND SHORT-RANGE PLANNING ACTIVITIES FOR THE JACKSONVILLE TRANSPORTATION AUTHORITY. EACH FORMULA GRANT APPORTIONMENT IS INCLUDED IN THIS MULTI-SOURCE GRANT AS A PROJECT.; ACTIVITIES PERFORMED: FUNDING UNDER S. 5307 URBANIZED AREA FORMULA GRANT (PROJECT 1). THE S. 5307 URBANIZED AREA FORMULA GRANT WILL FUND THE CCTV FOR SAFETY AND SECURITY SAFETY AND SECURITY ACCESS SYSTEMS UPGRADE ACROSS ALL JTA CAMPUSES CNG BUS PURCHASES AND THE ASSOCIATED TRAINING/INSPECTIONS CTC REPLACEMENT VEHICLES ELEVATOR UPGRADES ESCALATOR MODERNIZATION PLATFORM SIGNAGE HVAC REPLACEMENT BUS TRAINING SIMULATOR RAILING REPLACEMENT BUS WASH BLOWERS ENTERPRISE ASSET MANAGEMENT OVERLAY FERRY (PHASE V) IMPROVEMENTS HUMAN RESOURCE MANAGEMENT SYSTEM IT TECHNOLOGY NETWORK HARDWARE BUS STOP SHELTER SITEWORK AND AMENITIES SHOP EQUIPMENT RIDE-ON SWEEPERS LIFTS COMPUTER HARDWARE AND UPWP PLANNING TASKS. FUNDING UNDER S. 5337 URBANIZED AREA FORMULA GRANT (PROJECT 2) WILL FUND AN AUTOMATED INVENTORY STORAGE SYSTEM FOR THE SKYWAY. FUNDING UNDER S. 5339 URBANIZED AREA FORMULA GRANT (PROJECT 3) WILL FUND ELEVATOR UPGRADES.; EXPECTED OUTCOMES: THIS FUNDING WILL AID THE JACKSONVILLE TRANSPORTATION AUTHORITY IN CONTINUING TO PROVIDE SAFE RELIABLE EFFICIENT AND SUSTAINABLE MULTI-MODAL TRANSPORTATION SERVICES AND FACILITIES.; INTENDED BENEFICIARIES: OUR CUSTOMERS AND COMMUNITY PARTNERS WITHIN THE JACKSONVILLE URBANIZED AREA AND OUR REGIONAL PARTNERSHIPS.; SUBRECIPIENT ACTIVITIES: NONE

MURTHA CANCER TRANSLATIONAL CLINICAL RESEARCH: FRAMINGHAM LONGITUDINAL STUDY AND APPLIED PROTEOGENOMICS ORGANIZATIONAL LEARNING AND OUTCOMES (APOLLO)- FY22 CORE

HISTORICALLY BLACK COLLEGES AND UNIVERSITIES PROGRAM

MOUSE GENOME DATABASE (MGD): A CORE KNOWLEDGE RESOURCE FOR FUNCTIONAL CHARACTERIZATION OF THE HUMAN GENOME - PROJECT SUMMARY AS THE COST OF GENOME-SCALE SEQUENCING CONTINUES TO DECREASE AND NEW TECHNOLOGIES FOR GENOME EDITING BECOME WIDELY ADOPTED, THE LABORATORY MOUSE IS MORE IMPORTANT THAN EVER AS A MODEL SYSTEM FOR UNDERSTANDING THE BIOLOGICAL SIGNIFICANCE OF HUMAN GENETIC VARIATION AND FOR ADVANCING THE EMERGENCE OF GENOMIC MEDICINE. THE MOUSE GENOME DATABASE (MGD) HAS A UNIQUE AND STRATEGIC ROLE AS A COMMUNITY RESOURCE FOR FACILITATING THE USE OF THE LABORATORY MOUSE FOR UNDERSTANDING GENOMICS UNDERLYING HUMAN BIOLOGY AND DISEASE. MGD SERVES THREE MAJOR USER COMMUNITIES: (I) BIOMEDICAL RESEARCHERS WHO USE MOUSE EXPERIMENTATION TO INVESTIGATE GENETIC AND MOLECULAR PRINCIPLES OF BIOLOGY AND DISEASE PROCESSES, (II) TRANSLATIONAL SCIENTISTS WHO USE THE LABORATORY MOUSE TO MODEL HUMAN DISEASE, AND (III) BIOINFORMATICIANS/ COMPUTATIONAL BIOLOGISTS WHO USE THE RICH INTEGRATED DATA MGD PROVIDES TO DEVELOP ALGORITHMS AND BIOINFORMATICS TOOLS FOR DATA ANALYSIS AND INTERPRETATION. DURING THE PROJECT PERIOD, WE WILL CONTINUE TO CURATE AND INTEGRATE NEW GENETIC, GENOMIC, VARIANT, FUNCTIONAL, PHENOTYPIC, AND HUMAN DISEASE MODEL DATA ESSENTIAL TO RESEARCHERS USING THE LABORATORY MOUSE IN BIOMEDICAL RESEARCH. WE WILL MAKE THESE DATA FREELY AVAILABLE THROUGH A VARIETY OF WEB-BASED AND PROGRAMMATIC USER INTERFACES. OUR CORE AIMS INCLUDE: (I) MAINTAINING THE CANONICAL CATALOG OF MOUSE GENOME FEATURES, (II) SERVING AS THE AUTHORITATIVE DATA FOR MOUSE FUNCTIONAL ANNOTATIONS, AND (III) MAINTAINING A COMPREHENSIVE CATALOG OF MOUSE MUTATIONS AND STRAINS AND THEIR PHENOTYPE AND DISEASE MODEL ASSOCIATIONS. TO SUPPORT OUR AIMS, WE WILL MAINTAIN COST-EFFECTIVE SOFTWARE, DATABASE, AND HARDWARE USING INDUSTRY BEST PRACTICES. WE WILL MAINTAIN MGD'S SECURE INFRASTRUCTURE THROUGH REGULAR MAINTENANCE, UPGRADES, AND PLANNED EVOLUTION. WE WILL LEVERAGE EXISTING SOFTWARE COMPONENTS FROM THE ALLIANCE OF GENOME RESOURCES AND OTHER RESOURCES WHERE POSSIBLE AND FOCUS OUR SOFTWARE DEVELOPMENT ACTIVITIES ON UNIQUE INFRASTRUCTURE NEEDED TO SUPPORT OUR CORE AIMS. TO ENSURE THE GREATEST IMPACT OF MGD IN THE BROADER SCIENTIFIC COMMUNITY, WE WILL PROVIDE ROBUST USER SUPPORT AND OUTREACH THROUGH ONLINE USER DOCUMENTATION, TUTORIALS, TRAINING WORKSHOPS, AND ONE-ON-ONE ASSISTANCE USING A VARIETY OF COMMUNICATION MODALITIES AND MAJOR SOCIAL MEDIA TOOLS. WE WILL ACTIVELY SOLICIT COMMUNITY INPUT, DATA SUBMISSIONS, AND COLLABORATIONS.

APPLICATION PURPOSE: THIS MULTI-SOURCE GRANT (OR SUPER GRANT) WILL PROVIDE REPLACEMENT 35-FOOT CNG BUSES REPLACEMENT PARATRANSIT VANS AN OVERHAUL OF THE PASSENGER FERRY BOAT ALONG WITH THE BUS STOP AND BUS SHELTER IMPROVEMENTS IT TECHNOLOGY PURCHASES IMPLEMENTATION OF SAFETY AND SECURITY MEASURES AND LONG- AND SHORT RANGE PLANNING ACTIVITIES FOR THE JACKSONVILLE TRANSPORTATION AUTHORITY. EACH FORMULA GRANT APPORTIONMENT IS INCLUDED IN THIS MULTI-SOURCE GRANT AS A PROJECT.; ACTIVITIES PERFORMED: FUNDING UNDER S. 5307 URBANIZED AREA FORMULA GRANT (PROJECT 1). THE S. 5307 URBANIZED AREA FORMULA GRANT WILL FUND THE CCTV FOR SAFETY AND SECURITY SAFETY AND SECURITY ACCESS SYSTEMS UPGRADE ACROSS ALL JTA CAMPUSES CNG BUS PURCHASES AND THE ASSOCIATED TRAINING/INSPECTIONS CTC REPLACEMENT VEHICLES ELEVATOR CAB REPLACEMENT SKYWAY ESCALATOR CONVEYANCE SYSTEM PLATFORM SIGNAGE IT TECHNOLOGY BACKUP STORAGE IT HARDWARE SHOP EQUIPMENT BUS STOP AMENITIES BUS STOP SHELTER SITEWORK CAMERA EQUIPMENT AND ACCESSORIES SHOP EQUIPMENT RIDE-ON SWEEPERS BUS YARD (TECHNOLOGY) MANAGEMENT SYSTEM REPLACEMENT SUPPORT VEHICLES COMPUTER HARDWARE CONSTRUCTION OF A DRIVERS RESTROOM FERRY BOAT HAUL OUT SURVEILLANCE SOLAR LIGHT TRAILERS SURVEILLANCE CAMERA TRAILERS AND UPWP PLANNING TASKS. FUNDING UNDER S. 5337 URBANIZED AREA FORMULA GRANT (PROJECT 2) WILL FUND PROPULSION MOTORS AUX PROPULSION INVERTERS AND OTHER INVENTORY PARTS. FUNDING UNDER S. 5339 URBANIZED AREA FORMULA GRANT (PROJECT 3) WILL PURCHASE 2 AND 1/3 35-FOOT CNG BUSES ($628894 EACH) TO REPLACE 3 BUSES DIESEL BUSES THAT HAVE MET OR EXCEEDED THEIR USEFUL LIFE. ; EXPECTED OUTCOMES: THIS FUNDING WILL AID THE JACKSONVILLE TRANSPORTATION AUTHORITY IN CONTINUING TO PROVIDE SAFE RELIABLE EFFICIENT AND SUSTAINABLE MULTI-MODAL TRANSPORTATION SERVICES AND FACILITIES.; INTENDED BENEFICIARIES: OUR CUSTOMERS AND COMMUNITY PARTNERS WITHIN THE JACKSONVILLE URBANIZED AREA AND OUR REGIONAL PARTNERSHIPS. ; SUBRECIPIENT ACTIVITIES: NONE

MURTHA CANCER CENTER RESEARCH PROGRAM (MCCRP): FRAMINGHAM LONGITUDINAL STUDY AND APPLIED PROTEOGENOMICS ORGANIZATIONAL LEARNING AND OUTCOMES (APOLLO)

CENTER FOR REHABILITATION SCIENCES RESEARCH

PROJECT 1: PRAGMATIC ASSESSMENT OF INFLUENZA VACCINE EFFECTIVENESS IN THE DOD (PAIVED) PROJECT 2: COVID-19: 1) EPIDEMIOLOGY, IMMUNOLOGY AND CLINICAL CHARACTERISTICS OF EMERGING INFECTIOUS DISEASES WITH PANDEMIC POTENTIAL (EPICC-EID) 2) MILITARY REGISTRY ANALYSIS PROJECT (COVID M-RAP) 3)THE OBSERVATIONAL SEROEPIDEMIOLOGIC STUDY OF COVID-19 AT THE UNITED STATES NAVAL ACADEMY (TOSCANA)

CARES ACT CERTIFICATION AND AGREEMENT

PROGRAM PROJECT AWARDS

CENTER FOR NEUROSCIENCE AND REGENERATIVE MEDICINE (CNRM)

MODULATION OF LUNG IMMUNE RESPONSES TO VIRAL INFECTION

ESTABLISHING A MUTANT MOUSE REGIONAL RESOURCE CENTER AT THE JACKSON LABORATORY

THIS PROJECT WILL RECONSTRUCT AND MODERNIZE APPROXIMATELY 93 ACRES OF THE SSA MARINE CARGO TERMINAL ON BLOUNT ISLAND AND WILL BE COMPLETED ON A TOTAL OF 8 SEQUENTIAL PATCHES THAT ARE REFERRED TO AS PHASES 1-8. IT WILL IMPLEMENT A NEW PAVEMENT SYSTEM ADJUST THE EXISTING STORMWATER MANAGEMENT SYSTEM TO A NEW GRADE AND INSTALL NEW HIGH-MAST LIGHTING SIGNAGE UTITILTIES STRIPPING AND FENCING.

CARGO TERMINAL MODERNIZATION

MOUSE GENOME INFORMATICS

IMPROVE EXISTING AIRPORT

REGIONAL ANESTHESIA, ACUTE PAIN MANAGEMENT, BATTLEFIELD ANALGESIA

TRANSFORMING TECHNOLOGY FOR WARFIGHTERS

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND - INSTITUTION

BRAIN INJURY AND DISEASE PREVENTION, TREATMENT, AND RESEARCH

PRECLINICAL GENOME EDITING FOR RARE NEUROLOGICAL DISEASES - PROJECT SUMMARY OVERALL WHILE THE DEVELOPMENT OF HIGH-THROUGHPUT SEQUENCING TECHNOLOGY AND ITS APPLICATION TO CLINICAL DIAGNOSTICS HAS YIELDED THE GENETIC BASIS FOR MANY RARE GENETIC DISEASES, THE DEVELOPMENT OF EFFECTIVE TREATMENTS HAS NOT KEPT PACE. ALTHOUGH GENE REPLACEMENT AND MODULATION THERAPIES CAN BE POWERFUL, SOMETIMES EVEN LIFESAVING TREATMENT OPTIONS, THEY COME WITH MANY RISKS, SUCH AS IMMUNOGENICITY AND ONCOGENICITY. PROGRAMMABLE NUCLEASES SUCH AS CRISPR/CAS9 HAVE REVOLUTIONIZED OUR ABILITY TO MANIPULATE THE GENOME, AND PROVIDE THE POTENTIAL TO ACHIEVE LASTING, PRECISE GENOME MODIFICATION FOR THERAPEUTIC BENEFIT. THE PROPOSED U19 PROGRAM SEEKS TO ADDRESS THESE CHALLENGES THROUGH THE DEVELOPMENT, VALIDATION AND TRANSLATION OF GENE EDITING– BASED THERAPEUTIC SOLUTIONS FOR RARE NEUROLOGICAL GENETIC DISEASES. WE PROPOSE TO FOCUS ON FOUR NEUROLOGICAL CONDITIONS THAT EACH REPRESENT A SIGNIFICANT UNMET CLINICAL NEED: SPINAL MUSCULAR ATROPHY, FRIEDRICH'S ATAXIA, HUNTINGTON'S DISEASE, AND RETT SYNDROME. MEMBERS OF OUR TEAM HAVE DEVELOPED A SUITE OF BASE AND PRIME GENOME EDITING TOOLS THAT CAN INSTALL PRECISE ALTERATIONS WITHOUT CREATING A DSB OR REQUIRING A DONOR TEMPLATE. WE ALSO HAVE DEVELOPED VALIDATED IN VIVO MOUSE MODELS FOR EACH OF THESE DISEASES AND BRING DEEP EXPERTISE IN THE IND-ENABLING PRECLINICAL EVALUATION OF GENE-EDITING THERAPEUTICS. WE PROPOSE TO MERGE THESE CONSIDERABLE ASSETS WITH DISEASE-SPECIFIC EXPERTISE IN EACH OF THE FOUR NEUROLOGICAL CONDITIONS, SUPPORTED BY EXPERTISE AND RESOURCES FOR SCALED PRODUCTION OF AAV-BASED DELIVERY VECTORS FOR DELIVERY OF PRECISION GENE- EDITING THERAPIES TO TISSUES, AND FOR NAVIGATING THE REGULATORY PATH TO IND SUBMISSION. THE PROPOSED U19 TEAM HAS A TRACK RECORD OF INDIVIDUAL AND COLLABORATIVE SUCCESS AT EVERY STEP OF THE PRECLINICAL PIPELINE PATHWAY AND IS THUS WELL POSITIONED TO ACHIEVE OUR MILESTONES, WHICH INCLUDE AN IND PACKAGE SUBMITTED TO FDA FOR AT LEAST ONE THERAPY AND NEUROLOGICAL CONDITION. OUR OVERALL AIMS ARE TO: 1) ASSEMBLE A MULTI-DISCIPLINARY TEAM WITH UNIQUE STRENGTHS AND EXPERTISE TO DEVELOP AND IMPLEMENT INNOVATIVE GENOME EDITING STRATEGIES TO ADDRESS IMPORTANT DISEASE OF THE CNS, INCLUDING SPINAL MUSCULAR ATROPHY, FRIEDREICH'S ATAXIA, HUNTINGTON'S DISEASE, AND RETT SYNDROME; 2) OPTIMIZE LEAD BASE EDITOR AND PRIME EDITOR CANDIDATES FOR EACH DISEASE AREA, UTILIZING IN VITRO PLATFORMS AND VALIDATED ANIMAL MODELS; 3) EXECUTE DEFINITIVE PRECLINICAL IN VIVO PHARMACOLOGY STUDIES ON OPTIMIZED LEADS TO DEVELOP REPRODUCIBLE EFFICACY DATA, WHILE MONITORING BIODISTRIBUTION, PK/PD, TOLERABILITY, AND TOXICOLOGY; AND 4) ADVANCE ONE LEAD CANDIDATE TO AN ALLOWABLE INVESTIGATIONAL NEW DRUG (IND) APPLICATION THROUGH COORDINATED COMMUNICATION WITH THE FDA INTERACT PROGRAM, THE RESEARCH PROJECT TEAM, AND THE PROJECT CORES.

MISEQP; FAC; ALT.;FUEL BUSES(9);OA

NATIONAL GUARD BUREAU JOINT STAFF PREVENTION WORKFORCE SUPPORT PROJECT

SHOCK CENTER FOR AGING RESEARCH AT THE JACKSON LABORATORY

HIGH THROUGHPUT PRODUCTION AND CRYOPRESERVATION OF KNOCKOUT MICE

PURPOSE: CONSTRUCT DEICING PAD AND CONTAINMENT FACILITY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A NEW 94,000 SQUARE FOOT PUBLIC USE DEICING PAD INCLUDING CONTAINMENT FACILITY AND ASSOCIATED EQUIPMENT. THIS GRANT FUNDS PHASE 4, WHICH INCLUDES PAVING, CONTAINMENT SYSTEM, AND ASSOCIATED EQUIPMENT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH JACKSON, WYOMING.

"COVID-19". COVID-19 - 1) EPIDEMIOLOGY, IMMUNOLOGY AND CLINICAL CHARACTERISTICS OF EMERGING INFECTIOUS DISEASES WITH PANDEMIC POTENTIAL (EPICC-EID) 2) ADAPTIVE COVID-19 TREATMENT TRIAL(ACTT)

PATHOBIOLOGY OF NEURODEGENERATION IN C9ORF72 REPEAT EXPANSION

SCALABLE EXPANDED ACCESS WITH ANALYSIS OF NEUROFILAMENT AND OTHER BIOMARKERS FOR IBUDILAST IN ALS (SEA-NOBI-ALS) - PROJECT SUMMARY/ABSTRACT CURRENT TREATMENT OPTIONS FOR AMYOTROPHIC LATERAL SCLEROSIS (ALS) ARE INADEQUATE, AND MANY PATIENTS LIVING WITH ALS SEEK ACCESS TO EXPERIMENTAL THERAPIES WITH THE HOPE THAT THEY WILL BE EFFECTIVE. SINCE MOST PATIENTS ARE EXCLUDED FROM PARTICIPATION IN INTERVENTIONAL TRIALS BASED ON RESTRICTIVE INCLUSION AND EXCLUSION CRITERIA, EXPANDED ACCESS PROGRAMS (EAPS) CAN BRIDGE AN IMPORTANT GAP. AS SUCH, THROUGH AN EAP, WE ARE NOW PROPOSING TO OFFER A PROMISING DRUG – IBUDILAST – THAT IS PRESENTLY IN A PHASE 2/3 TRIAL FOR ALS. IBUDILAST HAS A WELL-ESTABLISHED FAVORABLE SAFETY RECORD AND HAS BEEN APPROVED FOR ASTHMA AND POST-STROKE SYMPTOMS IN JAPAN. MOST RELEVANT TO OUR APPLICATION IS THE FACT THAT IT IS ABLE TO PENETRATE THE CENTRAL NERVOUS SYSTEM AND HAS BENEFICIAL PHARMACOLOGICAL EFFECTS FOR ALS, SUCH AS PHOSPHODIESTERASE INHIBITION, INCREASED AUTOPHAGY, AND AMELIORATION OF TDP-43 PATHOLOGY. THIS EAP WILL OFFER IBUDILAST AS AN EXPERIMENTAL TREATMENT TO 200 ALS PATIENTS FOR 6 MONTHS. OUR PROJECT WILL DEVELOP A NETWORK OF ALS PHYSICIANS, TO BE MANAGED BY MAYO CLINIC AND WIDETRIAL, WHICH FEATURES SELF-ACTIVATION AND STREAMLINED WORKFLOWS WITH E-CONSENT AND ENROLLMENT, HOME-HEALTH VISIT ORDERING, DRUG SUPPLY ORDERING, AND OVERSIGHT OF SAFETY EVENTS AND OUTCOMES DATA CAPTURE. EVALUATIONS WILL BE DONE EITHER IN A PHYSICIAN’S OFFICE OR VIRTUALLY IN THE PATIENT’S HOME TO MINIMIZE THE BURDEN OF PARTICIPATION. SAFETY MONITORING WILL BE CONDUCTED BY THE TREATING PHYSICIAN AND THROUGH BLOOD DRAWN IN THE PATIENT’S HOME, PROCESSED IN A CENTRAL LABORATORY. WE WILL DETERMINE THE EFFECT OF IBUDILAST ON ALS PROGRESSION USING THE GOLD STANDARD PRIMARY CLINICAL TRIAL OUTCOME MEASURE – THE ALS FUNCTIONAL RATING SCALE REVISED (ALSFRS-R) – WITH THE EMERGING BIOMARKER NEUROFILAMENT LIGHT (NFL) AS CO-PRIMARY OUTCOME. GIVEN THE URGENT NEED FOR RELIABLE BIOMARKERS, WE WILL ALSO TEST OTHER CANDIDATES (E.G., TDP-43 MARKERS). FURTHERMORE, TO AID IN DIFFERENTIATING BETWEEN IBUDILAST RESPONDERS AND NON-RESPONDERS, WE WILL USE CUTTING-EDGE MULTI-OMIC SEQUENCING METHODS. OUR USAGE OF LONG-READ WHOLE- GENOME SEQUENCING ENABLES US TO SPAN THE FULL RANGE OF GENOMIC VARIATION, AND BY GENERATING COMPLEMENTARY TRANSCRIPTOMIC DATA, WE CAN CAPTURE RNA SIGNATURES AND DISEASE-RELEVANT CELL POPULATIONS. THUS, WE STRONGLY BELIEVE THAT OUR DATASETS WILL PROVIDE A VALUABLE RESOURCE AND CAN POSSIBLY ASSIST IN PATIENT STRATIFICATION. IN SUMMARY, OUR EAP WILL OFFER A PROMISING DRUG, BRING TOGETHER NOVEL WEB-BASED INFRASTRUCTURES, IMPLEMENT NOVEL BIOMARKERS, AND OBTAIN MULTI-OMIC PROFILES OF RESPONDERS, THEREBY ALLOWING TAILORED PERSONALIZED THERAPIES AND SETTING THE STAGE FOR FUTURE ALS CLINICAL TRIALS.

NATIONAL GUARD BUREAU STAR BEHAVIORAL HEALTH PROVIDER EXPANSION PROGRAM

TAS::57 3600 TAS:: FA8650-15-2-6F01 IS HEREBY ESTABLISHED FOR "BIOEFFECTS RESEARCH IN RHDJ" EFFORT IAW BASIC COOPERATIVE AGREEMENT FA8650-15-2-6608

CENTER FOR THE STUDY OF TRAUMATIC STRESS (CSTS)

IMPROVE EXISTING AIRPORT

PURPOSE: REHABILITATE TAXIWAY LIGHTING; REHABILITATE TAXIWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES 13,500 FEET OF THE EXISTING LIGHTING ON TAXIWAY A TO EXTEND ITS USEFUL LIFE. THIS PROJECT REHABILITATES 13,500 FEET OF THE EXISTING PAVED TAXIWAY A TO EXTEND ITS USEFUL LIFE. THIS GRANT FUNDS A PORTION OF PHASE 3, WHICH CONSISTS OF REHABILITATION OF 4,460 FEET. THIS GRANT IS ASSOCIATED WITH A BIPARTISAN INFRASTRUCTURE LAW AIRPORT GRANT THAT FUNDS THE REMAINING ELIGIBLE PORTION OF THE PROJECT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH JACKSON, MISSISSIPPI.

MOLECULAR AND CLINICAL BASED CARDIOVASVULAR CARE PROGRAM

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

PURPOSE:THIS MULTI-SOURCE GRANT (OR SUPER GRANT) CONSISTS OF FUNDING APPORTIONMENTS FROM THE FY 2021 FORMULA GRANTS - S. 5307 FOR CAPITAL AND PLANNING S. 5337 FOR STATE OF GOOD REPAIR AND S. 5339 FOR BUS AND BUS FACILITIES DESIGNATED FOR THE JACKSONVILLE TRANSPORTATION AUTHORITY. EACH FORMULA GRANT IS INCLUDED IN THIS MULTI-SOURCE GRANT AS A PROJECT.ACTIVITIES TO BE PERFORMED:FUNDING UNDER S. 5307 URBANIZED AREA FORMULA GRANT (PROJECT 1). THE S. 5307 URBANIZED AREA FORMULA GRANT WILL FUND THE CHURCH STREET GUARD HOUSE UPDATE (RENOVATION AND REHAB) ENTRANCE GATE AND MOTOR FOR THE PEDESTRIAN EMPLOYEE ENTRANCE CNG BUS PURCHASES AND THE ASSOCIATED TRAINING/INSPECTIONS CTC REPLACEMENT VEHICLES CTC EXPANSION VEHICLES AUTOMATIC VEHICLE MONITORING SYSTEM (HARDWARE AND ASSOCIATED TECHNOLOGY) SAFETY AND SECURITY ACCESS CONTROL UPGRADES PANELS AND CARD READERS FOR JTA FACILITIES BUS STOP SITE IMPROVEMENTS SITE WORK INSTALLATION AND SOLAR LIGHTING INTEGRATION OF ERP FOR TIME AND ATTENDANCE REVENUE EQUIPMENT ENHANCEMENTS AND UPGRADES OIL WATER SEPARATOR SYSTEM FOR SURFACE PARKING LOTS IT HARDWARE ERP ENTERPRISE ASSET MANAGEMENT MODULE (EAM) OPTIMIZATION SECURITY CAMERA AND SUPPORT EQUIPMENT FOR THE KINGS AVENUE GARAGE PARK AND RIDE A CANOPY FOR THE JRTC AT LAVILLA SKYWAY STATION SKYWAY TRAIN PARTS SKYWAY CONTROL ROOM EQUIPMENT SKYWAY PROPULSION MOTORS AND AUX AND PROPULSION INVERTERS PRINT SHOP COPIER DVR UPGRADES FOR ROLLING STOCK DUAL PURPOSE INVERTER MODULE AND ENERGY STORAGE SYSTEM BATTERIES FOR HYBRID BUSES GANTRY CHAIN SYSTEM FOR THE PASSENGER FERRY REAL TIME PASSENGER INFORMATION SYSTEM ESCALATOR REHAB AND RENOVATION AT THE KINGS AVENUE SKYWAY STATION ERP HR OPTIMIZATION SUPPORT FALL PROTECTION EQUIPMENT ASSOCIATED WITH THE HYBRID BUSES FOR THE ELECTRIC SHOP UPWP PLANNING TASKS REHABILITATION AND RENOVATION (MODERNIZATION) OF SKYWAY ESCALATOR AT THE KINGS AVENUE STATION CYBER SECURITY DISASTER RECOVERY AND MULTI-FACTOR AUTHENTICATION HARDWARE AND SOFTWARE FOR BUS TRANSIT OPERATIONS CTC CONNEXION PARATRANSIT SERVICES AND SKYWAY OPERATIONS. THE FY 2021 S. 5307 APPORTIONMENT IS $14445566. THE JTA LOCAL CASH MATCH FOR UPWP IS $320000. AUTHORIZED USE OF TOLL REVENUE CREDITS IN THE AMOUNT OF $3291392.FUNDING UNDER S. 5337 URBANIZED AREA FORMULA GRANT (PROJECT 2) WILL FUND PROPULSION MOTORS AUX PROPULSION INVERTERS SHOP EQUIPMENT LIKE SCRUBBERS WIRELESS LIFTS TRAIN WASH EQUIPMENT FORKLIST(S) AND A 2-BAY 2-STORY PREFABRICATED BUILDING FOR EXTENDED STORAGE. THE FY 2021 S. 5337 APPORTIONMENT IS $740870. AUTHORIZED USE OF TOLL REVENUE CREDITS IN THE AMOUNT OF $185218.FUNDING UNDER S. 5339 URBANIZED AREA FORMULA GRANT (PROJECT 3) WILL PURCHASE TWO AND 3/5TH 35-FOOT CNG BUSES ($604062 EACH) TO REPLACE 3 BUSES DIESEL BUSES THAT HAVE MET OR EXCEEDED THEIR USEFUL LIFE. THE FY 2021 S. 5339 APPORTIONMENT IS $1575034. AUTHORIZED USE OF TOLL REVENUE CREDITS IN THE AMOUNT OF $393759.EXPECTED OUTCOMES: CONTINUED EFFICIENCIES.INTENDED BENEFICIARIES:OUR CUSTOMERS AND COMMUNITY PARTNERS WITHIN THE JACKSONVILLE URBANIZED AREA AND OUR REGIONAL PARTNERSHIPS.SUBRECIPIENT ACTIVITIES:NONE

APPLICATION PURPOSE: TO ASSIST WITH MASS TRANSIT CAPITAL MASS TRANSIT OPERATIONS SKYWAY OPERATIONS CTC CAPITAL AND CTC OPERATIONS.; ACTIVITIES PERFORMED: WORK PERTAINING TO CONTINUED OPERATIONS AND CAPITAL PROJECTS OF THE MASS TRANSIT SYSTEM IN DUVAL COUNTY JACKSONVILLE FLORIDA AND THE PROCUREMENT OF GOODS AND SERVICES FOR BUS OPERATIONS SKYWAY OPERATIONS AND FOR CTC OPERATIONS.; EXPECTED OUTCOMES: FUNDING FOR CAPITAL AND PLANNING PROJECTS TO ENHANCE THE AUTHORITYS GOAL OF BECOMING A PERFORMANCE-BASED AGENCY.; INTENDED BENEFICIARIES: OUR CUSTOMERS AND COMMUNITY PARTNERS WITHIN THE JACKSONVILLE URBANIZED AREA.; SUBRECIPIENT ACTIVITIES: NONE.

MR-04 EXTENSIONS

FIRST COAST FLYER (FCF) SOUTHWEST CORRIDOR BUS RAPID TRANSIT (BRT) PROJECT; JACKSONVILLE TRANSPORTATION AUTHORITY (JTA); JACKSONVILLE FL

IMPROVE EXISTING AIRPORT

OPERATION LIVE WELL: STRATEGIC PLANNING FOR THE FUTURE

NMRC RESEARCH AND DEVELOPMENT OF PROTECTIVE VACCINES AND OTHER COUNTERMEASURES AGAINST INFECTIOUS DISEASE AGENTS OF MILITARY IMPORTANCE

PURPOSE: CITY OF JACKSONVILLE; AWARD NA24NMFX463C0056; APPL ID: 11098068 THE CITY OF JACKSONVILLE, NORTH CAROLINA WILL RESTORE CRITICAL HABITAT AND ALLEVIATE FLOODING WITHIN THE URBAN, UNDERSERVED COASTAL COMMUNITY OF THE NEW RIVER WATERSHED THROUGH FOUR PROJECT AREAS. IN ADDITION TO RESTORING HABITAT, THIS PROJECT WILL IMPROVE WATER QUALITY, RECREATIONAL ACCESS, AND COMMUNITY RESILIENCE. THIS PROJECT BUILDS UPON THE SUCCESSFUL NEW RIVER ESTUARY OYSTER HIGHWAY AND WILSON BAY PROJECT THROUGH WETLAND RESTORATION, CULVERT REPLACEMENT, LIVING SHORELINE CREATION, AND OUTPLANTING OF ONE MILLION OYSTERS.

APPLIED PROTEOGENOMICS ORGANIZATIONAL LEARNING AND OUTCOMES (APOLLO) - FY23 CORE

MR-08 EXTENTIONS

JTA BUS RAPID TRANSIT SE CORRIDOR

UNKNOWN TITLE

COMPUTATIONAL BIOLOGY INITIATIVE FOR MILITARY MEDICINE

RECOVERY ACT: THE CITY OF JACKSONVILLE ENERGY EFFICIENCY APPLICATION

APPLICATION PURPOSE: THE ST. JOHNS RIVER FERRY REGIONAL CONNECTIVITY PROJECT (THE PROJECT) IS A PACKAGE OF IMPROVEMENTS TO THE ST. JOHNS RIVER FERRY BETWEEN HISTORIC COASTAL COMMUNITIES IN THE JACKSONVILLE FLORIDA REGION. THE ST. JOHNS RIVER FERRY PROVIDES THE NORTHEAST FLORIDA REGION WITH ENHANCED CONNECTIVITY AND A RELIABLE SUSTAINABLE TRANSPORTATION OPTION. THE PROJECT INCLUDES SUSTAINABILITY AND OPERATIONAL IMPROVEMENTS INCLUDING A NEW LOW-EMISSION VESSEL AND UPGRADES TO THE CURRENT FUELING SYSTEM. THESE IMPROVEMENTS ARE ESSENTIAL TO ENSURING PEOPLE HAVE RELIABLE SAFE AND EFFICIENT MOBILITY OUTSIDE THE DOWNTOWN CORE.; ACTIVITIES PERFORMED: THIS PROJECT WILL INCLUDE THE DESIGN AND PURCHASE OF A NEW LOW-EMISSION VESSEL AND UPGRADES TO THE CURRENT FUELING SYSTEM.; EXPECTED OUTCOMES: THIS INITIATIVE NOT ONLY AIMS TO IMPROVE MOBILITY AND CONNECTIVITY BUT ALSO SEEKS TO MITIGATE ENVIRONMENTAL IMPACTS AND SUPPORT THE RESILIENCE AND DEVELOPMENT OF A COMMUNITY FACED WITHPERSISTENT POVERTY AND HISTORICAL DISADVANTAGES.; INTENDED BENEFICIARIES: OUR CUSTOMERS AND COMMUNITY PARTNERS WITHIN THE JACKSONVILLE URBANIZED AREA AND OUR REGIONAL PARTNERSHIPS.; SUBRECIPIENT ACTIVITIES: NONE.

INVESTIGATING REGIONAL AND CELLULAR VULNERABILITIES TO TAU PATHOLOGY IN YOUNG-ONSET ALZHEIMER'S DISEASE - PROJECT SUMMARY/ABSTRACT DEVELOPMENT OF COGNITIVE PROBLEMS AT ANY AGE IS DEVASTATING, BUT DEVELOPMENT OF COGNITIVE PROBLEMS IN WORKING-AGE PEOPLE WITH DEPENDENTS REPRESENTS A MAJOR PUBLIC HEALTH CONCERN. YOUNG-ONSET ALZHEIMER'S DISEASE (YOAD) IS DEFINED AS INDIVIDUALS WHO PRESENT BEFORE AGE 65 AND LACK MUTATIONS KNOWN TO CAUSE ALZHEIMER'S DISEASE (AD) PATHOLOGY. NEUROPATHOLOGY AND NEUROIMAGING STUDIES DEMONSTRATE GREATER TAU ACCUMULATION IN YOAD WHO OFTEN PRESENT WITH ATYPICAL, NON-AMNESTIC SYNDROMES. OUR PRELIMINARY DATA DEMONSTRATES THAT TAU ACCUMULATION OCCURS THROUGH PROGRESSIVE MATURITY LEVELS IN TANGLE-BEARING NEURONS, WHICH DISPROPORTIONATELY AFFECTS CORTICAL MORE THAN LIMBIC STRUCTURES IN YOAD. MOREOVER, WE SHOW YOUNGER AGE ONSET IS ASSOCIATED WITH GREATER TANGLE ACCUMULATION AND NEURONAL LOSS IN NUCLEUS BASALIS OF MEYNERT (CHOLINERGIC HUB) AND LOCUS COERULEUS (NORADRENERGIC HUB) – TWO NEUROMODULATORY HUBS IMPLICATED IN EARLY STAGE OF DISEASE. AS STEREOTYPIC AMYLOID-SS PLAQUE PATTERNS ARE ROBUSTLY OBSERVED REGARDLESS OF AGE, AND COMORBID NEUROPATHOLOGIES ARE LESS FREQUENT IN YOAD, THIS COHORT IS IDEALLY SUITED FOR A TARGETED INVESTIGATION OF SELECTIVE VULNERABILITIES TO TANGLE PATHOLOGY IN AD. REGIONAL VULNERABILITIES TO ADVANCED TANGLE MATURITY LEVELS IN CORTICOLIMBIC STRUCTURES AND NEUROMODULATORY HUBS ARE HYPOTHESIZED TO UNDERLIE THE SYNDROMIC HETEROGENEITY OBSERVED IN YOAD. THE OVERALL GOAL OF THIS GRANT IS TO UNCOVER SIGNATURES OF REGIONAL AND CELLULAR VULNERABILITIES UNDERLYING SYNDROMIC HETEROGENEITY IN YOAD BY INVESTIGATING WHAT MODIFIES PATTERNS OF TANGLE ACCUMULATION AND MICROGLIAL ACTIVATION. OUR PRELIMINARY DATA FROM SINGLE-CELL RNA SEQUENCING UNDERSCORES THE IMPORTANCE OF CONSIDERING DISEASE HETEROGENEITY AND THE UTILITY OF QUANTITATIVE NEUROPATHOLOGY FOR VALIDATING GENE EXPRESSION CHANGES. THIS PROPOSAL SEEKS TO SHIFT CURRENT RESEARCH IN AD BY FOCUSING ON YOUNGER-AGED INDIVIDUALS AND DEMONSTRATING HOW REGIONAL VARIABILITY CAN INFORM CELLULAR BIOLOGY EVEN IN THE CONTEXT OF END-STAGE DISEASE. TO ACCOMPLISH OUR GOALS AND FACILITATE STRATIFICATION BY ATYPICAL AND TYPICAL (AMNESTIC) CLINICAL SYNDROMES, THE MPI TEAM HAS COMBINED EXPERTISE AND RESOURCES TO AMASS ONE OF THE LARGEST DOCUMENTED YOAD COHORTS TOTALING 558 BRAINS WITH AVAILABLE TISSUE FOR STUDY. THE GOAL OF THE GRANT IS TO TEST THE FOLLOWING HYPOTHESES: 1) MODIFIERS OF THE NEUROPATHOLOGIC PATTERNS OF TAU PATHOLOGY IN YOAD BRAINS DIFFER BETWEEN CASES STRATIFIED BY ATYPICAL VS. TYPICAL (AMNESTIC) CLINICAL SYNDROMES, 2) THE MOST VULNERABLE NEURONAL POPULATIONS TO AD-TAU SHARE A SIMILAR MOLECULAR SIGNATURE ACROSS CORTICOLIMBIC REGIONS REFLECTIVE OF SYNDROMIC HETEROGENEITY IN YOAD, AND 3) CORTICOLIMBIC MICROGLIAL ACTIVATION PATTERNS DIFFER IN THE BRAINS OF YOAD CASES STRATIFIED BY ATYPICAL VS. TYPICAL (AMNESTIC) CLINICAL SYNDROME. COMPLETION OF THIS PROJECT WILL IDENTIFY SPECIFIC CELL POPULATIONS VULNERABLE TO REGIONAL AD-TAU PATHOLOGY AND IDENTIFY MODIFIERS OF MICROGLIAL ACTIVATION PATTERNS CORRESPONDING TO AGGRESSIVE TAU ACCUMULATION IN YOAD.

USU INTRAMURAL RESEARCH PROGRAM

DEFENSE HEALTH PROGRAM (DHP) INFRASTRUCTURE FUNDS

APPLICATION PURPOSE: THE PURPOSE OF THIS FUNDING IS TO REPLACE OLDER DIESEL BUSES WITH SAFE RELIABLE AND SUSTAINABLE CNG BUSES AND IMPROVE SERVICE RELIABILITY FOR RIDERS IN AND AROUND JACKSONVILLE.; ACTIVITIES PERFORMED: THE JACKSONVILLE TRANSPORTATION AUTHORITY WILL PURCHASE 23 40-FOOT CNG BUSES.; EXPECTED OUTCOMES: THE JACKSONVILLE TRANSPORTATION AUTHORITY WILL REPLACE 23 40-FOOT DIESEL BUSES WITH 23 CLEAN BURNING CNG BUSES.; INTENDED BENEFICIARIES: OUR CUSTOMERS AND COMMUNITY PARTNERS WITHIN THE JACKSONVILLE URBANIZED AREA AND OUR REGIONAL PARTNERSHIPS.; SUBRECIPIENT ACTIVITIES: NONE

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

DEVELOPMENT OF A MALARIA VACCINE FOR THE US MILITARY

FY 2020 CARES ACT SECTION 5307 OPERATING COSTS; JTA: JACKSONVILLE FL

IMPROVE EXISTING AIRPORT

THE JACKSON LABORATORY CENTER FOR PRECISION GENETICS

GENE ONTOLOGY CONSORTIUM

BIOMATHEMATICAL MODELS FOR INDIVIDURAL PREDICTION OF CONGNITIVE PERFORMANCE IMPAIRMENT DUE TO SLEEP

DEPARTMENT OF DEFENSE AND VETERANS AFFAIRS MULTI-CENTER COHORT STUDY EVALUATING INFECTION ASSOCIATED CLINICAL OUTCOMES IN HOSPITALIZED MEDICAL EVACUE

SYNERGISTIC INTERACTION OF AMYLOID-BETA AND ALPHA-SYNUCLEIN IN LEWY BODY DEMENTIA

DEFENSE VETERANS CENTER FOR INTEGRATIVE PAIN MANAGEMENT (DCCIPM)

5307 CAPITAL AND PLANNING; JTA: JACKSONVILLE FL

FY 2020 CARES ACT SECTION 5307 CAPITAL PLANNING FUTURE SERVICES; JTA: JACKSONVILLE FL

HIGHER EDUCATION EMERGENCY RELIEF FUND - INSTITUTION

A RESEARCH COLLABORATORY TO EXPLORE BEST PRACTICES FOR EXPANDING ACCESS TO CARE THROUGH THE EXPANSION AND SUPPORT OF TELEHEALTH CARE FOR CHILDREN AND FAMILIES WITH BEHAVIORAL HEALTH NEEDS

"COVID-19". DOD COVID-19 RAPID EVALUATION AND STUDY OF THE PANDEMIC OUTBREAK NATIONALLY BY SUSTAINING AND LEVERAGING PROLONGED FIELD CARE RESEARCH EFFORTS

A RESEARCH COLLABORATORY TO EXPLORE BEST PRACTICES FOR EXPANDING ACCESS TO CARE THROUGH THE EXPANSION AND SUPPORT OF TELEHEALTH CARE FOR CHILDREN AND FAMILIES WITH BEHAVIORAL HEALTH NEEDS

STAFFING FOR ADEQUATE FIRE AND EMERGENCY RESPONSE (SAFER)

CENTER FOR PROSTATE CANCER (CPDR)

APPLICATION PURPOSE: THIS GRANT WILL PROVIDE REPLACEMENT 40-FOOT CNG BUSES REPLACEMENT PARATRANSIT VANS SHOP EQUIPMENT ALONG WITH THE BUS STOP AND BUS SHELTER IMPROVEMENTS IT TECHNOLOGY PURCHASES IMPLEMENTATION OF SAFETY AND SECURITY MEASURES PREVENTATIVE MAINTENANCE AND LONG- AND SHORT-RANGE PLANNING ACTIVITIES FOR THE JACKSONVILLE TRANSPORTATION AUTHORITY.; ACTIVITIES PERFORMED: THE S. 5307 URBANIZED AREA FORMULA GRANT WILL FUND SAFETY AND SECURITY CNG BUS PURCHASES AND THE ASSOCIATED TRAINING/INSPECTIONS CTC REPLACEMENT VEHICLES FARE COLLECTION EQUIPMENT PREVENTATIVE MAINTENANCE IT TECHNOLOGY AND COMPUTER HARDWARE BUS STOP SHELTER SITEWORK AND AMENITIES SHOP EQUIPMENT AND UPWP PLANNING TASKS.; EXPECTED OUTCOMES: THIS FUNDING WILL AID THE JACKSONVILLE TRANSPORTATION AUTHORITY IN CONTINUING TO PROVIDE SAFE RELIABLE EFFICIENT AND SUSTAINABLE MULTI-MODAL TRANSPORTATION SERVICES AND FACILITIES.; INTENDED BENEFICIARIES: OUR CUSTOMERS AND COMMUNITY PARTNERS WITHIN THE JACKSONVILLE URBANIZED AREA AND OUR REGIONAL PARTNERSHIPS.; SUBRECIPIENT ACTIVITIES: NONE

PORT OF PASCAGOULA INTERMODAL IMPROVEMENT PROJECT

FY 08 SECTION 5307 CAPITAL, PLANNIN

CENTER FOR THE STUDY OF TRAUMATIC STRESS (CSTS) PROGRAM

PURPOSE: CONSTRUCT TAXIWAY; REHABILITATE TAXIWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A NEW 1,500 FOOT PAVED TAXIWAY A TO BRING THE AIRPORT INTO CONFORMITY WITH CURRENT STANDARDS. THIS PROJECT REHABILITATES 2,400 FEET OF THE EXISTING PAVED TAXIWAY A TO MAINTAIN THE STRUCTURAL INTEGRITY OF THE PAVEMENT AND TO MINIMIZE FOREIGN OBJECT DEBRIS TO EXTEND ITS USEFUL LIFE. THIS GRANT FUNDS PHASE 4, WHICH CONSISTS OF CONSTRUCTION OF 1,150 FEET. THIS GRANT FUNDS PHASE 4, WHICH CONSISTS OF REHABILITATION OF 575 FEET. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH JACKSON, WYOMING.

SPECIAL MOUSE STRAINS RESOURCE

PURPOSE: REHABILITATE TAXIWAY LIGHTING; REHABILITATE TAXIWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES 13,500 FEET OF THE EXISTING TAXIWAY A PAVEMENT TO EXTEND ITS USEFUL LIFE. THIS PROJECT REHABILITATES 4,800 FEET OF THE EXISTING TAXIWAY B PAVEMENT TO EXTEND ITS USEFUL LIFE. THIS PROJECT REHABILITATES THE EXISTING TAXIWAY A, A1, A2, A3, A4, A5, A6, AND A7 LIGHTING SYSTEMS TO EXTEND THEIR USEFUL LIVES AND ENHANCE SAFE AIRFIELD OPERATIONS DURING LOW VISIBILITY CONDITIONS. THIS GRANT FUNDS THE FIRST PHASE, WHICH CONSISTS OF REHABILITATION OF 1,850 FEET. THIS GRANT FUNDS THE SECOND PHASE, WHICH CONSISTS OF 8,300 FEET OF REHABILITATION. THIS GRANT FUNDS 22% OF THE FIRST PHASE. THIS PROJECT IS ASSOCIATED WITH A BIPARTISAN INFRASTRUCTURE LAW AIRPORT INFRASTRUCTURE GRANT THAT FUNDS THE REMAINING ELIGIBLE PORTION OF THE FIRST PHASE. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH JACKSON, MISSISSIPPI.

APPLICATION PURPOSE: THE PURPOSE OF THIS FUNDING IS TO PURCHASE VEHICLES.; ACTIVITIES PERFORMED: THE ACTIVITIES OF THIS FUNDING ARE TO PURCHASE HEAVY DUTY DIESEL ELECTRIC HYBRID BUSES GASOLINE CUTAWAY BUSES AND GASOLINE VANS. THIS FUNDING WILL ALSO BE USED FOR DELIVERY COSTS.; EXPECTED OUTCOMES: THE PURCHASE OF THESE VEHICLES AND EQUIPMENT WILL HELP TO REPLACE EXPAND AND MODERNIZE THE EXISTING DIESEL FLEET WITH HYBRIDS AND GASOLINE VEHICLES.; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES OF THIS PROJECT WILL BE ALL RESIDENTS AND VISITORS OF THE CITY OF JACKSON MS.; SUBRECIPIENT ACTIVITIES: NONE

FY 2017 SEC 5307 CAPITAL PLANNING; JTA; JACKSONVILLE FLA

SUICIDE AVOIDANCE FOCUSED ENHANCED GROUP USING ALGORITHM RISK DETECTION (SAFEGUARD)

DIAGNOSIS, EVALUATION AND TREATMENT OF COMBAT TRAUMATIC BRAIN INJURY

RESEARCH AND DEVELOPMENT OF OPERATIONAL AND UNDERSEA MEDICAL ISSUES OF MILITARY IMPORTANCE

A RANDOMIZED EFFECTIVENESS TRIAL OF A SYSTEMS-LEVEL APPROACH TO STEPPED CARE FOR WAR-RELATED PTSD

CENTER FOR NEUROSCIENCE AND REGENERATIVE MEDICINE (CNRM)FY21 CORE PROGRAM

INTEGRATIVE CARDIAC HEALTH PROJECT (ICHP) - CENTER OF EXCELLENCE

3D HUMAN MICROTISSUE MODELS FOR CANCER AND INFECTIOUS DISEASE PREPAREDNESS PROJECT

FY 2016 SECTION 5307 CAPITAL AND PLANNING

GYNECOLOGIC DISEASE PROGRAM

ELECTRONIC ACCESS TO MOUSE TUMOR DATA

CONSORTIUM FOR HEALTH AND MILITARY PERFORMANCE (CHAMP), HUMAN PERFORMANCE RESOURCE CENTER (HPRC), AND OPERATION SUPPLEMENT SAFETY (OPSS)

FY 2015 SECTION 5307 CAPITAL AND PLANNING

BRAIN INJURY AND DISEASE PREVENTION, TREATMENT, AND RESEARCH

CAPITAL, PLANNING

SICKLE CELL TRAIT: ETHNIC, PHYSIOLOGIC AND GENETIC VARIABILITY AND EXERTION

PA-25

AN INTEGRATIVE ANALYSIS OF STRUCTURAL VARIATION FOR THE 1000 GENOMES PROJECT

THE JACKSON LABORATORY KOMP2 PHENOTYPING CENTER

MURTHA CANCER CENTER COMPREHENSIVE RESEARCH (MCC)

BRAIN INJURY AND DISEASE PREVENTION, TREATMENT, AND RESEARCH - FY24 CORE

CENETER FOR NEUROSCIENCE AND REGENERATIVE MEDICINE (CNRM)/(CORE PROGRAM)

BRAIN INJURY AND DISEASE PREVENTION, TREATMENT, AND RESEARCH - FY22 CORE

APPLICATION PURPOSE: THE BAY STREET INNOVATION CORRIDOR IN JACKSONVILLE FLORIDA EXEMPLIFIES THE UNIQUE COLLABORATION OF COMMUNITY LEADERS TO CREATE THE INITIAL PHASE OF AN AUTONOMOUS TRANSPORTATION NETWORK TO SUPPORT ECONOMIC DEVELOPMENT STRATEGIES AND A VISION FOR A SAFE VIBRANT AND ACCESSIBLE DOWNTOWN JACKSONVILLE. THIS PROJECT IS THE INITIAL PHASE OF THE ULTIMATE URBAN CIRCULATOR (U2C AND IT INTRODUCES AUTONOMOUS VEHICLES ALONG BAY STREET WITHIN THE JACKSONVILLE URBAN CORE; ACTIVITIES PERFORMED: CREATING APPROXIMATELY 3 MILES OF AT-GRADE AUTONOMOUS VEHICLE SERVICE ALONG BAY STREET FROM PEARL ST. WHILE HEADING EAST TO THE SPORTS ENTERTAINMENT AND PLANNED MULTI -USE COMPLEX. JTA PLANS TO LEVERAGE 6 CURRENT STATIONS (INFRASTRUCTURE) WITH EXPANSION TO A TOTAL OF 12 BRANDED STATIONS.PURCHASE OF NEW SUPERVISORY CONTROL/OPERATING SYSTEM AND 14 FEDERALLY COMPLIANT AUTONOMOUS VEHICLES.INTEGRATING SMART CORRIDOR TECHNOLOGIES ADVANCED COMMUNICATION AND SAFETY FEATURES:- APPROXIMATELY 17 CONNECTED INTERSECTIONS - APPROXIMATELY 4 PEDESTRIAN SENSORS- APPROXIMATELY 2 FLOOD SENSORS- MIXED USE SAFETY SURVEILLANCE/CCTV CAMERAS; EXPECTED OUTCOMES: THE BAY STREET INNOVATION CORRIDOR WILL UNIQUELY TRANSFORM DOWNTOWN MOBILITY ENHANCING SAFETY EFFICIENCY AND ACCESSIBILITY ALONG A CRITICAL EAST-WEST CORRIDOR IN DOWNTOWN JACKSONVILLE.; INTENDED BENEFICIARIES: OUR CUSTOMERS AND COMMUNITY PARTNERS WITHIN THE JACKSONVILLE URBANIZED AREA AND OUR REGIONAL PARTNERSHIPS.; SUBRECIPIENT ACTIVITIES: NONE.

SERVICE ACADEMY LONGITUDINAL MTBI OUTCOMES STUDY (SALTOS)

IMPROVE EXISTING AIRPORT

FY 09 SECTION 5307 CAPITAL, PLANNIN

HOLISTIC HEALTH AND FITNESS (H2F)