Namic Inc

THE SCOPE OF THE ACAT2 PROGRAM IS LIMITED TO EMERGING AND FORESEEABLE ADVANCED TECHNOLOGIES RATHER THAN EITHER THOSE ALREADY IN FULL PRODUCTION OR JU

COOPERATIVE AGREEMENT FOR ROBOTICS COLLABORATIVE TECHNOLOGY ALLIANCE (RCTA)

RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN-LICENSED AND TEXAS-EXEMPT AND FLORIDA-DELICENSED ONLY - THIS APPLICATION REQUESTS CONTINUATION FUNDING FOR THE CHILDRENFIRST PROGRAM TO CONTINUE OPERATIONS FOR 100 BEDS AT THE SUNNYSIDE FACILITY.

RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN-LICENSED AND TEXAS-EXEMPT AND FLORIDA-DELICENSED ONLY

INCREMENTAL FUNDINF FOR FY04 APP

RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN-PRELICENSED - CHILDRENFIRST RESIDENTIAL CARE PROGRAM WILL PROVIDE BASIC RESIDENTIAL CARE.

RESIDENTIAL (SHELTER) SERVICES FOR UNACCOMPANIED ALIEN CHILDREN

RESIDENTIAL (SHELTER) SERVICES FOR UNACCOMPANIED ALIEN CHILDREN

RESIDENTIAL (GROUP HOME, SHELTER, TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED ALIEN CHILDREN - DYNAMIC SERVICE SOLUTIONS - CHILDREN FIRST RESIDENTIAL CARE (GASMER) IS A FEDERALLY FUNDED RESIDENTIAL SHELTER PROGRAM WITHIN THE OFFICE OF REFUGEE RESETTLEMENT (ORR) THAT PROVIDES TEMPORARY CARE AND SERVICES FOR UNACCOMPANIED ALIEN CHILDREN ARRIVING IN THE UNITED STATES WITHOUT PARENTS OR LEGAL GUARDIANS. THE PROGRAM ENSURES CHILDREN RECEIVE ESSENTIAL SERVICES INCLUDING HOUSING, MEDICAL CARE, EDUCATION, AND MENTAL HEALTH SUPPORT WHILE IDENTIFYING AND VETTING SUITABLE SPONSORS THROUGH COMPREHENSIVE BACKGROUND CHECKS. THE PRIMARY OBJECTIVE IS TO SAFELY REUNITE CHILDREN WITH VETTED SPONSORS IN THE LEAST RESTRICTIVE ENVIRONMENT WHILE MAINTAINING ONGOING CASE MANAGEMENT AND SUPPORT SERVICES.

RESIDENTIAL (GROUP HOME, SHELTER, TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED ALIEN CHILDREN - DYNAMIC SERVICE SOLUTIONS - CHILDREN FIRST RESIDENTIAL CARE (SUNNYSIDE) IS A FEDERALLY FUNDED RESIDENTIAL SHELTER PROGRAM WITHIN THE OFFICE OF REFUGEE RESETTLEMENT (ORR) THAT PROVIDES TEMPORARY CARE AND SERVICES FOR UNACCOMPANIED ALIEN CHILDREN ARRIVING IN THE UNITED STATES WITHOUT PARENTS OR LEGAL GUARDIANS. THE PROGRAM ENSURES CHILDREN RECEIVE ESSENTIAL SERVICES INCLUDING HOUSING, MEDICAL CARE, EDUCATION, AND MENTAL HEALTH SUPPORT WHILE IDENTIFYING AND VETTING SUITABLE SPONSORS THROUGH COMPREHENSIVE BACKGROUND CHECKS. THE PRIMARY OBJECTIVE IS TO SAFELY REUNITE CHILDREN WITH VETTED SPONSORS IN THE LEAST RESTRICTIVE ENVIRONMENT WHILE MAINTAINING ONGOING CASE MANAGEMENT AND SUPPORT SERVICES.

VEHICLE-INTEGRATED NATURAL GAS COMPRESSOR

SATELLITE COMMUNICATION (SATCOM) TRANSCEIVER PRODUCTION PROJECT

ROBOT-ASSISTED COGNITIVE TRAINING FOR SOCIALLY ISOLATED OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT

THE GOAL OF THIS PROJECT IS TO DEMONSTRATE NOBLE THERMODYNAMIC SYSTEMS' CORE TECHNOLOGY, THE ARGON POWER CYCLE (APC) EMISSIONS, PERFORMANCE, AND COST CHARACTERISTICS AS A H2 FUELED FLEXIBLE CHP SYSTEM; MAINLY ITS ABILITY TO MAINTAIN ITS EXCELLENT EFFICIENCY, FLEXIBILITY AND CLEANLINESS (I.E. ZERO NOX) QUALITIES AS IT MODULATES ITS OUTPUT TO MEET A VARYING DEMAND OF INDUSTRIAL-GRADE PROCESS HEAT AND ELECTRIC POWER. THROUGH ITS INCREASED EFFICIENCY GAINS AND RETROFITTABLE NATURE, THE APC WILL ENABLE THE U.S. INDUSTRIAL AND POWER SECTORS TO DECARBONIZE, MAKING USE OF GIGAWATTS OF EXISTING RECIPROCATING ENGINE ASSETS AT A WIDE RANGE OF SCALES TO TRANSITION AWAY FROM FOSSIL FUEL, SUPPORTING THE ACCELERATED BUILDOUT OF RENEWABLE HYDROGEN INFRASTRUCTURE, STRENGTHENING THE U.S. INDUSTRIAL SECTOR’S COST COMPETITIVENESS, AND IMPROVING THE RESILIENCY OF THE U.S. GRID.

IN SILICO RANDOMIZED CONTROL TRIAL FRAMEWORK FOR ASSESSING INFECTION CONTROL AND PREVENTION INTERVENTIONS IN THE HOSPITAL

MOD 6 - INCREASE IN VALUE $255000; CHANGE IN MILESTONE SCHEDULE

INFLATION REDUCTION ACT (IRA) – METHOD TO MITIGATE METHANE LOST DURING LIQUIDS UNLOADING THE PROJECT OBJECTIVE IS TO INCORPORATE NEW FUNCTIONALITY INTO ONBOARD DYNAMICS’ CURRENT GOVAC® SYSTEM THAT WILL ENABLE NATURAL GAS PRODUCERS TO CAPTURE METHANE THAT WOULD TRADITIONALLY BE VENTED TO THE ATMOSPHERE WHILE REMOVING ACCUMULATED LIQUIDS FROM THE WELLBORE.

ULTRA-EFFICIENT CHP WITH HIGH POWER/HEAT RATIO USING A NOVEL ARGON POWER CYCLE

A MOBILE INFORMATICS SOLUTION TO AID IN MEMORY

TREATMENT OPTIMIZATION OF BRAIN-INJURED WARFIGHTERS: A PRESCRIBED SUB-SYMPTOMATIC EXERCISE TREATMENT (TOBI-SET)

DESIGNING LOW-COST, CUSTOMIZABLE HIGH-DENSITY PROBES FOR ACUTE AND CHRONIC NEURAL RECORDINGS IN RODENTS - SUMMARY UNDERSTANDING HOW THE BRAIN CONTROLS BEHAVIOR REQUIRES STUDYING THE DYNAMIC ACTIVITY OF DIFFERENT TYPES OF NEURONS IN DISTRIBUTED NEURAL CIRCUITS IN AWAKE BEHAVING ANIMALS. CURRENTLY, THERE ARE FEW TECHNOLOGIES AVAILABLE HOWEVER THAT ALLOW RESEARCHERS TO RECORD THE ACTIVITY OF HUNDREDS TO THOUSANDS OF NEURONS AT ARBITRARY DEPTH IN THE BRAINS OF AWAKE, BEHAVING ANIMALS. WHILE THERE HAS BEEN MUCH RECENT PROGRESS IN THE DEVELOPMENT OF HIGH-DENSITY MICRO-FABRICATED SILICON PROBES, CURRENT COMMERCIALLY AVAILABLE PROBES OFFER LITTLE TO NO CUSTOMIZABILITY TO THE MORPHOLOGY OF DIFFERENT BRAIN REGIONS AND DIFFERENT CELL TYPES WITHIN BRAIN REGIONS. EVEN MORE IMPORTANTLY, THERE ARE NO COMMERCIALLY AVAILABLE SOLUTIONS OF HIGH-DENSITY PROBES WITH INTEGRATED STIMULATION CAPABILITIES ENABLING CAUSAL, CLOSED-LOOP EXPERIMENTATION. IN PHASE I, WE DESIGNED AND FABRICATED CUSTOMIZABLE HIGH-DENSITY RECORDING PROBES FOR ACUTE HEAD-FIXED RECORDINGS AND STREAMLINED OUR FABRICATION STRATEGIES. THE RESULTING DEVICES HAD HIGH YIELDS OF FUNCTIONAL ELECTRODE SITES AND WERE SUCCESSFULLY USED BY BETA-TESTER LABS TO GENERATE DATA WITH GOOD SIGNAL-TO-NOISE RATIOS. WE FURTHERMORE BUILT AN ONLINE GRAPHICAL INTERFACE WHERE END-USERS CAN DESIGN THEIR PROBES AND SUBMIT THEIR DESIGNS FOR FABRICATION. IN PHASE II, NEURAL DYNAMICS TECHNOLOGIES LLC WILL DEVELOP CUSTOMIZABLE, HIGH-DENSITY PROBES WITH INTEGRATED CLOSED-LOOP CAPABILITIES THAT CAN BE CHRONICALLY IMPLANTED FOR USE IN ANIMALS THAT ARE EITHER HEAD-FIXED OR ABLE TO MOVE AROUND FREELY. THE FIRST AIM OF OUR PHASE II PROPOSAL IS TO INTEGRATE LIGHT DELIVERY AND ELECTRICAL STIMULATION CAPABILITIES ONTO OUR PROBES TO ENABLE CLOSED-LOOP EXPERIMENTATION. THE LOCATIONS FOR LIGHT DELIVERY AND ELECTRICAL STIMULATION WILL BE CUSTOMIZABLE SO THAT CUSTOMERS CAN SPECIFY THEIR DESIRED LOCATION. THE SECOND AIM WILL BE TO DEVELOP A PACKAGING APPROACH THAT INVOLVES BUILDING AN APPLICATION SPECIFIC INTEGRATED CIRCUIT (ASIC) AND A HEAD-STAGE THAT CAN CONTROL ALL INTEGRATED FUNCTIONALITIES. THE COMBINED PACKAGED DEVICE WILL BE SMALL ENOUGH TO ENABLE CHRONIC EXPERIMENTS IN EITHER HEAD- FIXED OR FREELY MOVING ANIMALS. THE THIRD AIM WILL BE TO PERFORM BOTH BENCH-TOP TESTING AND IN VIVO ANIMAL TESTING OF DEVICES TO ESTABLISH BASIC FUNCTIONALITY AND EFFECTIVENESS OF THE DEVICES. IN SUMMARY, NDT WILL DESIGN INNOVATIVE CLOSED-LOOP INTERFACES THAT WILL ENABLE CAUSAL STUDIES ADDRESSING THE FUNCTIONAL ROLE OF DIFFERENT BRAIN REGIONS AND NEURON TYPES IN THE BRAINS OF BOTH HEAD-FIXED AND FREELY MOVING ANIMALS. THESE TYPES OF CLOSED-LOOP DEVICES MAY BE FURTHER EVOLVED INTO NEURAL IMPLANTS TO TREAT NEUROLOGICAL DISEASES SUCH AS REFRACTORY EPILEPSY, PARKINSON’S AND OTHER TREMOR DISORDERS.

SOLAR THERMAL BIOSOLIDS-TO-FERTILIZER DEMONSTRATION

ADVANCED METHODS FOR EFFICIENT AEROELASTIC ANALYSIS OF WIND TURBINES AND WIND FARMS

A COMPACT INSTRUMENT FOR TIME-RESOLVED AIRBORNE PARTICLE CHEMISTRY

ADD A TASK AND INCREMENTAL FUNDS FOR THE 2ND APP

USING STRUCTURED LIGHT SENSING WITH MACHINE LEARNING TO DETECT UNWITNESSED IN-HOME FALLS - PROJECT SUMMARY/ABSTRACT OLDER ADULTS ARE DISPROPORTIONATELY AFFECTED BY FALLS. OLDER ADULTS WHO HAVE MEMORY LOSS (MILD TO MODERATE COGNITIVE IMPAIRMENT) CAN FORGET TO WEAR WIRELESS ALERT PENDANTS OR WRISTBANDS THAT ARE USED IN CASE THEY FALL IN THEIR HOME. FALLS AMONG ADULTS 65 AND OLDER CAUSED OVER 34,000 DEATHS IN 2019, MAKING IT THE LEADING CAUSE OF INJURY DEATH FOR THAT GROUP. OLDER ADULT FALLS COST $50 BILLION IN MEDICAL COSTS ANNUALLY. OF THOSE WHO FALL, MANY SUFFER SERIOUS INJURIES, SUCH AS HIP FRACTURES AND HEAD TRAUMAS, WHICH REDUCES THEIR MOBILITY, INDEPENDENCE, AND LIFE EXPECTANCY. STUDIES HAVE FOUND AN INCREASED RISK OF COMPLICATIONS ASSOCIATED WITH PROLONGED PERIODS OF LYING ON THE FLOOR FOLLOWING A FALL. OLDER ADULTS LIVING ALONE OR WITH MEMORY LOSS ARE AT THE GREATEST RISK OF DELAYED ASSISTANCE FOLLOWING A FALL AND CANNOT ALWAYS BE COUNTED ON TO USE THEIR WEARABLE EMERGENCY ALERT BUTTON. A LOW-COST, UNOBTRUSIVE SYSTEM CAPABLE OF AUTOMATICALLY DETECTING AND ALERTING FALLS IN THE HOMES OF OLDER ADULTS LIVING ALONE OR THOSE WITH MILD TO MODERATE COGNITIVE IMPAIRMENT, COULD HELP SIGNIFICANTLY REDUCE THE INCIDENCE OF DELAYED ASSISTANCE AFTER A FALL. THIS PHASE II PROJECT, BUILDING ON A SUCCESSFUL PHASE I PROJECT, WILL DEVELOP AN INNOVATIVE NEW IN-HOME FALL MONITORING SYSTEM THAT SOLVES MANY PRACTICAL PROBLEMS WITH EXISTING SYSTEMS. THE TECHNICAL APPROACH USES STRUCTURED LIGHT SENSING (SLS) THAT CREATES 3D POINT CLOUDS OF A SCENE TO ALLOW DETECTION OF MOTION SEQUENCES USING MACHINE LEARNING (ML) ALGORITHMS WHICH WILL ALLOW FOR THE AUTOMATIC DETECTION OF A PERSON’S FALL. THERE ARE MULTIPLE BENEFITS OF THIS APPROACH FOR THE TARGET USERS: 1. THE PERSON IS NOT REQUIRED TO CARRY OR WEAR AN ELECTRONIC DEVICE THAT MIGHT BE FORGOTTEN TO BE WORN. 2. NO ACTION IS REQUIRED TO BE TAKEN BY THE PERSON AFTER A FALL. 3. THE SYSTEM DOES NOT USE VISIBLE LIGHT VIDEO THAT WOULD CREATE PRIVACY CONCERNS FOR THE PERSON. 4. THE SYSTEM CAN WORK IN DARKNESS OR VERY LOW LIGHT UNLIKE VISIBLE LIGHT CAMERA-BASED APPROACHES. 5. THE SYSTEM IS UNOBTRUSIVE AND WORKS WITH EXISTING PERSONAL EMERGENCY RESPONSE SYSTEMS (PERS), WITH MINIMAL OR NO ACTIVE USER INTERACTION. THE SLS FALL DETECTION SYSTEM IS INTENDED TO WORK WITH MULTIPLE VENDORS OF IN-HOME ALERT SYSTEMS. IT WILL OPERATE IN LIEU OF OR IN PARALLEL WITH, WEARABLE BUTTONS TO SIGNAL AN ALERT. THE PROPOSED SYSTEM WOULD BE USED IF CAREGIVERS DETERMINE THAT A WEARABLE BUTTON IS NOT AN ADEQUATE SOLUTION FOR THE PERSON BEING MONITORED. THE PROPOSED DEVICES WILL BE MOUNTED HIGH ON THE WALL OF EACH ROOM AND WILL WIRELESSLY COMMUNICATE TO A CENTRAL DEVICE IN THE HOME. THE CENTRAL DEVICE WILL SEND THE ALERT TO THE IN-HOME ALERT SYSTEM UPON DETECTING A FALL. THE PROPOSED SOLUTION WILL NOT REQUIRE ANY INTERNET CONNECTIVITY. THE OUT-OF-HOME COMMUNICATION METHOD IS PROVIDED BY THE CHOSEN VENDOR OF THE IN-HOME ALERT SYSTEM.

THE PROJECT TEAM WILL BUILD A TEST SYSTEM TO EVALUATE THE MECHANICAL PERFORMANCE OF SCALED-DOWN MOLTEN SALT STORAGE TANKS. DIFFERENT TANK DESIGNS WILL BE EVALUATED THROUGH MODELING OF THE FULL-SIZE AND SCALED DESIGNS BEFORE TESTING.

REMOTELY SUPERVISED TDCS COMBINED WITH COGNITIVE TRAINING TO IMPROVE COMPLEX ATTENTION IN ACTIVE-DUTY SERVICE MEMBERS AND VETERANS WITH MILD TBI

NEW SBIR PHASE I 2009: ER85352 TITLE: HIGH EFFICIENCY R744 CENTRIFUGAL CHILLER; PI: GIRI AGRAWAL

UTAH STATE UNIVERSITY RESEARCH FOUNDATION JOINT RESEARCH PROGRAM IN OPTICAL SENSOR CALIBRATION.

DECENTRALIZED CLINICAL TRIAL OF CONTINGENCY MANAGEMENT DIGITAL THERAPEUTIC TO TREAT STIMULANT USE DISORDER - ABSTRACT WITH NO FDA-APPROVED MEDICATIONS AVAILABLE TO ADDRESS STIMULANT USE DISORDERS (STUD) AND RISING PREVALENCE OF STIMULANTS NATIONALLY, CONTINGENCY MANAGEMENT (CM) HAS GAINED ATTENTION AS ONE OF FEW EFFECTIVE TREATMENT OPTIONS. DESPITE GROWING CLINICAL INTEREST IN CM, IMPLEMENTATION BARRIERS POSE SUBSTANTIAL CHALLENGES TO MOVING THIS EVIDENCE-BASED INTERVENTION INTO ROUTINE USE. CHIEF AMONG THESE CONCERNS IS LACK OF REIMBURSEMENT PATHWAYS AND DIFFICULTY IMPLEMENTING CM WITH FIDELITY (RASH ET AL., 2012, 2020). PRESCRIPTION DIGITAL THERAPEUTICS, MOBILE APP BASED PRODUCTS THAT ARE FDA-CLEARED FOR THE TREATMENT OF DISEASE, HAVE SHOWN PROMISE IN OVERCOMING REIMBURSEMENT CHALLENGES BY TAKING ADVANTAGE OF EXISTING FORMULARY BILLING PATHWAYS FOR DRUGS AND MEDICAL DEVICES. ALSO, DELIVERY OF CM THROUGH AN APP ADDRESSES MANY OF THE BARRIERS OF DAY-TO-DAY IMPLEMENTATION WITHIN THE CLINICAL WORKFLOW, MAINTAINS PROTOCOL ADHERENCE, AND IMPROVES PATIENT ACCESS–MAKING IT MORE LIKELY TO BE ADOPTED AND IMPACTFUL. THEREFORE, DYNAMICARE HEALTH HAS DEVELOPED AND PILOTED DCH-003, A DIGITAL THERAPEUTIC DELIVERING CM AND OTHER EVIDENCE-BASED MODALITIES FOR THE TREATMENT OF STUD. UNLIKE COMPETITOR PRODUCTS THAT INCLUDE CM SUCH AS THE PDT RESET FROM PEAR THERAPEUTICS, DCH-003 FULLY AUTOMATES CM THROUGH REMOTE, RANDOM, SELF-ADMINISTERED RAPID SALIVA TESTS WITNESSED OVER SELFIE VIDEO, AND IS DESIGNED AS A FULL YEAR PROGRAM (VS. 90 DAYS). DCH-003 ALSO INCORPORATES EVIDENCE-BASED, SELF-GUIDED THERAPY MODULES, APPOINTMENT TRACKING, AND DELIVERS REWARDS VIA A RISK-PROTECTIVE SMART DEBIT CARD. THE PRODUCT PROMISES GREATER ACCESSIBILITY AND FIDELITY TO CM, AND ULTIMATELY GREATER IMPACT ON STUD THAN CURRENTLY AVAILABLE TREATMENTS. THIS STUDY PROPOSES A PHASE II, TWO-GROUP, RANDOMIZED CLINICAL TRIAL (RCT) THAT WILL PROVIDE THE NECESSARY EFFICACY DATA IN ORDER TO SEEK FDA CLEARANCE OF DCH-003 FOR THE TREATMENT OF STUD. PATIENTS WITH STUD (N = 270) WILL BE RANDOMIZED TO: A) INTERVENTION: STANDARD CLINIC CARE PLUS DCH-003 OR B) CONTROL: STANDARD CLINIC CARE PLUS A TIME- AND EFFORT-CONTROLLED SHAM DIGITAL APP (TO CONTROL FOR PLACEBO EFFECT). THE PRIMARY OUTCOME WILL BE THE PERCENT STIMULANT ABSTINENT SAMPLES COLLECTED DURING WEEKS 1-38. SECONDARY OUTCOMES INCLUDE OTHER CLINICALLY RELEVANT INDICATORS (ABSTINENCE FROM OTHER ILLICIT SUBSTANCES, TREATMENT RETENTION, LONG-TERM (WEEKS 39-64) PERCENT NEGATIVE SAMPLES). AIM 1 COMPARES DCH-003 TO SHAM CONTROL, AND WE EXPECT BETTER CLINICAL OUTCOMES IN THE INTERVENTION VS. CONTROL GROUP. AIM 2 COMPARES HEALTHCARE UTILIZATION AND COSTS BETWEEN THE GROUPS, WITH THE GOAL OF PAYER ADOPTION POST-FDA-CLEARANCE. IMPORTANTLY, THIS STUDY WILL BE THE FIRST RCT FOR DCH-003 (ESSENTIAL FOR FDA CLEARANCE), AND, MORE BROADLY, IT ADDRESSES A CRITICAL NEXT STEP IN THE TRANSLATION OF SCIENCE TO CLINICAL PRACTICE THAT IS VITAL FOR DRIVING ADOPTION OF THIS PROVEN, EFFECTIVE PARADIGM INTO ROUTINE CARE AMIDST A U.S. STIMULANT EPIDEMIC.

DROP C: THE DROP-IN, RING-OF-POWER HELIOSTAT FOR COLLECTS< 6 ¢/KWH LEVELIZED COST OF ENERGY GOAL

HARDENING ADVANCED METHODS FOR PREDICTING 3D UNSTEADY FLOWS AROUND WIND TURBINES FOR INDUSTRIAL USE

TAS::89 0222::TAS NEW PHASE I SBIR; TITLE: AN ULTRAFINE FOCUSING SYSTEM TO SEPARATE PARTICULATE AND GASEOUS CONSTITUENTS OF ATMOSPHERIC AEROSOLS; PI

HIGH-DIMENSIONAL COMPRESSIVE SCANNING TRANSMISSION ELECTRON MICROSCOPY

INCENTIVIZED COLLABORATIVE CARE TO DESSEMINATE CONTINGENCY MANAGEMENT - ABSTRACT CONTINGENCY MANAGEMENT, AN INCENTIVE-BASED INTERVENTION, BOASTS A MASSIVE RESEARCH BASE AND HAS BEEN DEMONSTRATED EFFICACY IN INCREASING DRUG ABSTINENCE AND MEDICATION ADHERENCE IN PEOPLE WITH OPIOID USE DISORDER. THERE IS A HUGE GAP BETWEEN THE EVIDENCE IN SUPPORT OF THIS APPROACH AND ITS DISSEMINATION IN PRACTICE. A DIGITAL HEALTH PROGRAM THAT SURMOUNTS MOST OF THE BARRIERS TO DISSEMINATION HAS BEEN DEVELOPED THAT COLLECTS ALL THE RELEVANT DATA AND IMPLEMENTS ALL OF THE CONTINGENCY MANAGEMENT PROCEDURES AUTOMATICALLY. THIS PROGRAM HAS BEEN SHOWN TO BE EFFICACIOUS IN SEVERAL PEER-REVIEWED STUDIES. HOWEVER, ONE KEY BARRIER TO DISSEMINATION REMAINS. IN ORDER FOR CONTINGENCY MANAGEMENT TO BECOME TRULY IMPACTFUL ON A NATIONAL SCALE, PROVIDERS MUST ACTIVELY ENGAGE PATIENTS BY INFORMING THEM ABOUT IT, ENCOURAGING THEM TO USE IT, ASSISTING THEIR ENROLLMENT, AND THEN USING THE DATA GENERATED BY THE PLATFORM TO INFORM THEIR ONGOING CARE. THE BEST WAY TO SURMOUNT THIS FINAL BARRIER IS TO USE THE MOTIVATIONAL TECHNIQUE OF CONTINGENCY MANAGEMENT ITSELF; INCENTIVIZE THE NECESSARY PROVIDER BEHAVIORS. THUS, THIS SBIR FAST TRACK APPLICATION PROPOSES TO DEVELOP AND EVALUATE A NOVEL INCENTIVIZED COLLABORATIVE CARE MODEL FOR THE DELIVERY OF CONTINGENCY MANAGEMENT SERVICES FOR BUPRENORPHINE PHARMACOTHERAPY PATIENTS WITH OPIOID USE DISORDERS. WE BELIEVE THIS MODEL WILL HAVE THE IMPORTANT SECONDARY EFFECT OF INCREASING ACCESS TO BUPRENORPHINE PHARMACOTHERAPY, AS PRESCRIBERS WILL BE INDIRECTLY INCENTIVIZED TO MAXIMIZE THE NUMBER OF BUPRENORPHINE PATIENTS IN THEIR PRACTICE. PHASE I WILL BEGIN WITH PREPARATORY ACTIVITIES, INCLUDING STREAMLINING THE ENROLLMENT SYSTEM SO THAT ANY BUPRENORPHINE PRESCRIBER CAN USE IT, ADDING DATA COLLECTION SYSTEMS FOR PROVIDER INFORMATION, AND DATA DISPLAY SYSTEMS THAT PROVIDERS CAN USE TO EASILY ACCESS THE PATIENT DATA THEY WISH TO SEE. A PHASE I FEASIBILITY STUDY (N = 10) WILL FOLLOW. THE MILESTONES REQUIRE THE POTENTIAL OF THE INCENTIVIZED COLLABORATIVE CARE MODEL IN DISSEMINATING CONTINGENCY MANAGEMENT TO BE DEMONSTRATED. IF SUCCESSFUL, THE FEASIBILITY STUDY WILL PAVE THE WAY FOR A RANDOMIZED CONTROLLED TRIAL (RCT). THIS RCT WILL BE THE PRIMARY ACTIVITY OF PHASE II OF THIS SBIR AWARD, AND IS DESIGNED TO EVALUATE THE EFFICACY OF INCENTIVIZED COLLABORATIVE CARE IN THE DISSEMINATION OF CONTINGENCY MANAGEMENT. PRIMARY OUTCOME MEASURES WILL INCLUDE THE ENGAGEMENT IN COLLABORATIVE CARE IN RELATION TO THE CONTINGENCY MANAGEMENT INTERVENTION, AS WELL AS BUPRENORPHINE PRESCRIBING TRENDS. SECONDARY ANALYSES WILL BE DESIGNED TO ASSESS THE ECONOMIC EFFECT OF DYNAMICARE ON PROVIDERS. THE RCT WILL ALSO INCLUDE EXPLORATORY ANALYSES OF PATIENT OUTCOMES. OVERALL, THIS PROJECT IS HIGHLY CONSISTENT WITH CURRENT ONDCP PRIORITIES TO, “IDENTIFY AND ADDRESS POLICY BARRIERS RELATED TO CONTINGENCY MANAGEMENT INTERVENTIONS (MOTIVATIONAL INCENTIVES),” AND “EXPLORE REIMBURSEMENT FOR MOTIVATIONAL INCENTIVES AND DIGITAL TREATMENT FOR ADDICTION.” IF SUCCESSFUL, THIS PROJECT COULD LEAD TO RAPID DISSEMINATION OF CONTINGENCY MANAGEMENT AND IMPROVED ACCESS TO BUPRENORPHINE PHARMACOTHERAPY TO PEOPLE WITH OPIOID USE DISORDER THROUGHOUT THE UNITED STATES.

RESIDENTIAL (SHELTER) SERVICES FOR UNACCOMPANIED ALIEN CHILDREN

MULTI-LEVEL MODELING TO INFORM INTERVENTIONS FOR CONTROL OF MULTIDRUG-RESISTANT ORGANISMS WITHIN HEALTHCARE NETWORKS

ADAPTIVE MEASUREMENT OF NUCLEI PARTICLE SIZE AND CONCENTRATION

A NIST/UTAH STATE UNIVERSITY RESEARCH FOUNDATION JOINT RESEARCH PROGRAM IN OPTICAL SENSOR CALIBRATION

3D PRINTED MULTIFUNCTIONAL BRAIN WINDOWS FOR SIMULTANEOUS OPTICAL IMAGING AND ELECTROPHYSIOLOGY

VALIDATION OF COGNITIVE ENHANCEMENT TECHNIQUES FOR MILD TRAUMATIC BRAIN INJURY (VOCET-MTBI).

INSTANTANEOUS AEROSOL MOBILITY SIZING

DEVELOPMENT OF SYSTEM FOR PRODUCTION AND USE OF FROZEN-DRIED RED BLOOD CELLS (FDRBC)

DYNAMIC IR WINDOW FILM TO IMPROVE WINDOW ENERGY EFFICIENCY

SMART MOLTEN SALT TROUGH: SIMPLIFIED MELTING AND ROTATION-JOINT TECHNOLOGY FOR MOLTEN SALT TROUGHS

AEROSOL CHEMISTRY FIELD CALIBRATION SYSTEM

HOME-BASED LEG DEXTERITY TRAINER FOR MANAGEMENT OF KNEE OSTEOARTHRITIS - PROJECT SUMMARY NEUROMUSCULAR DYNAMICS, LLC HAS DEVELOPED THE LEG DEXERITY SYSTEM, A PATENTED PORTABLE, WIRELESS DEVICE FOR SHORT-LATENCY SENSORIMOTOR CIRCUIT NEUROMUSCULAR TRAINING USING UNSTABLE DYNAMIC FOOT-GROUND INTERACTIONS THAT CAN BE UTILIZED AS NONSURGICAL MANAGEMENT OF KNEE OA TO REDUCE PAIN AND IMPROVE FUNCTION. THE LEG DEXERITY SYSTEM WAS DESIGNED TO BE USED IN A SEATED POSITION THAT ALLOWS USERS TO COMPRESS A PLATFORM ATOP A SLENDER SPRING, WHICH BECOMES UNSTABLE AS IT BEGINS TO BUCKLE AT LOW FORCES. SUSTAINING PRESSURE WHILE MAINTAINING STABILITY OVER THE SPRING CHALLENGES AND TRAINS THE USER'S PROPRIOCEPTIVE AND NEUROMUSCULAR CONTROL, FOCUSING SPECIFICALLY ON THE LOW-LEVEL CIRCUITRY ESSENTIAL FOR PROPER KNEE MECHANICS. THE TABLET COMPUTER CONNECTED TO THE DEVICE, LINKED TO A HIPAA-COMPLIANT CLOUD PLATFORM, PROVIDES PARTICIPANTS WITH FEEDBACK DURING USE AND UPLOADS PARTICIPANT ACTIVITY DATA TO THE SERVER FOR ANALYSIS AND REPORTING THAT IS ACCESSIBLE TO BOTH PARTICIPANTS AND CLINICIANS TO INFORM CONTINUED CARE. THIS DIRECT-TO-PHASE II PROJECT PRIMARILY AIMS TO CLINICALLY VALIDATE AND ENABLE A GO-TO-MARKET STRATEGY FOR THE LEG DEXTERITY SYSTEM AS A HOME-BASED EXERCISE DEVICE FOR THE NONSURGICAL MANAGEMENT OF KNEE OA. THIS PROJECT WILL UTILIZE A LONGITUDINAL BLINDED DOSE-MATCHED TRIAL COMPARING 8 WEEKS OF LEG DEXTERITY TRAINING (TREATMENT USING A SLENDER, UNSTABLE SPRING THAT ENGAGES SHORT-LATENCY SENSORIMOTOR CONTROL, 42 PARTICIPANTS) VS. STABLE LEG PRESSES (PLACEBO USING WIDER, STABLE SPRING, 42 PARTICIPANTS) AT THE STEADMAN PHILIPPON RESEARCH INSTITUTE. THE PROJECT ENVISIONS THE SYSTEM BEING USED IN ABOUT 1,600 CLINICS, REPRESENTING AROUND 3% OF PHYSICAL THERAPY CLINICS IN THE UNITED STATES, WITHIN FIVE YEARS. THIS ADOPTION IS PROJECTED TO IMPROVE CARE FOR OA PATIENTS AND GENERATE CLINIC INCOME THROUGH BILLABLE REMOTE THERAPEUTIC MONITORING (RTM) BY INTEGRATING A ROBUST, REMOTE, INDUSTRY-STANDARD CLINICAL UI/UX THAT CLINICIANS CAN USE TO IMPROVE THEIR REMOTE CARE AND GROW THEIR RTM REVENUE.

APPLYING TECHNOLOGY-ENABLED CONTINGENCY MANAGEMENT FOR ALCOHOL USE DISORDER AT SCALE IN A MEDICAID POPULATION

THE PROJECT OBJECTIVE IS TO DESIGN, DEVELOP, MANUFACTURE AND TEST AN INNOVATIVE OIL-FREE, FOIL BEARING SUPPORTED COMPRESSOR/EXPANDER (CE) AND MOTOR DRIVE FOR HEAVY DUTY TRUCK FUEL CELL SYSTEMS. THE CE WILL MEET THE PERFORMANCE, DURABILITY, LIFE AND COST TARGETS OF THE M2FCT PROGRAM. THE OUTCOME OF THIS PROJECT IS A HIGH SPEED CENTRIFUGAL COMPRESSOR-EXPANDER SUPPORTED ON FOIL AIR BEARINGS AND ASSOCIATED MOTOR DRIVE. AT THE COMPLETION OF THIS PROGRAM, THE CE WILL HAVE DEMONSTRATED THE PERFORMANCE, DURABILITY, AND LIFE REQUIREMENTS OF THE FOA. A COST MODEL WILL BE SUBMITTED WITH A MANUFACTURING PLAN LAYING OUT THE PATH FOR HIGH VOLUME PRODUCTION.

COMPREHENSIVE TIME-RESOLVED MOLECULAR SPECIATION OF GASEOUS AND PARTICULATE ORGANIC CONSTITUENTS IN THE ATMOSPHERE

A SIMPLE AND QUANTITATIVE CLINICAL ASSESSMENT OF NEUROMUSCULAR RECOVERY AFTER ACL INJURY

AEROSOL SIZE DISTRIBUTIONS FOR UAV PLATFORMS

RAPID ASSESSMENT OF PARTICLE HYGROSCOPIC GROWTH

COUPLED AERODYNAMIC AND OPTICAL SIZING FOR COARSE PARTICLES

ANATOMIC IMAGING DERIVED 4D HEMODYNAMICS USING DEEP LEARNING - SUMMARY - ABSTRACT THORACIC AORTIC ANEURYSM IS A HIGHLY PREVALENT DISEASE WHICH CAN LEAD TO DEVASTATING COMPLICATIONS INCLUDING DISSECTION OR RUPTURE. EARLY DETECTION AND REGULAR MONITORING OF THESE PATIENTS VIA REGULAR SURVEILLANCE IMAGING IS ESSENTIAL TO GUIDE THERAPY MANAGEMENT. THE CURRENT PARADIGM FOR RISK ASSESSMENT IN THESE PATIENTS IS BASED ON PRIMITIVE SIZE THRESHOLDS WITH POOR PREDICTIVE VALUE FOR AORTIC COMPLICATIONS. THERE IS STRONG EVIDENCE THAT 4D HEMODYNAMIC BIOMARKERS ARE DRIVERS OF AORTIC COMPLICATIONS AND CAN IMPROVE RISK ASSESSMENT AND THERAPY MANAGEMENT. TO OBTAIN THESE BIOMARKERS, A HIGHLY SPECIALIZED MRI TECHNIQUE - 4D FLOW MRI - IS REQUIRED WHICH ALLOWS FOR THE DIRECT IN VIVO MEASUREMENT OF AORTA 4D HEMODYNAMICS. HOWEVER, SEVERAL LIMITATIONS IMPEDE WIDER CLINICAL TRANSLATION, INCLUDING THE LACK OF ACCESS TO DEDICATED MRI SYSTEMS AND 4D FLOW MRI PROTOCOLS, BURDENSOME AND TIME-CONSUMING (30+ MINUTES) POST-PROCESSING, AND INTERPRETATION OF 4D FLOW DATA REQUIRING DEDICATED SOFTWARE AND HIGHLY SPECIALIZED EXPERTISE. TO ADDRESS THESE LIMITATIONS, THIRD COAST DYNAMICS IS DEVELOPING A CLOUD-BASED ARTIFICIAL INTELLIGENCE (AI)-BASED PLATFORM CALLED TCDFLOW THAT CAN REPLACE 4D FLOW MRI BY PROVIDING 4D HEMODYNAMIC OUTPUT DIRECTLY FROM WIDELY AVAILABLE ROUTINE AND EASY-TO-OBTAIN CLINICAL ANATOMIC IMAGES OF THE CHEST. OUR PROOF-OF-CONCEPT STUDIES HAVE LEVERAGED A LARGE DATABASE OF >6700 EXISTING 4D FLOW MRI PATIENT DATA TO DEVELOP A PROTOTYPE TCDFLOW FLUID PHYSICS INFORMED DEEP LEARNING NEURAL NETWORK FOR THE PREDICTION OF 4D AORTIC HEMODYNAMICS USING ANATOMIC IMAGES AS INPUT DATA. FURTHER DEVELOPMENT, EVIDENCE GENERATION, AND STEPS TOWARD COMMERCIALIZATION WILL BE CONDUCTED IN A TWO-PHASE APPROACH. PHASE 1 (P1) FOCUSES ON FURTHER DEVELOPMENT AND FINE-TUNING OF THE THIS COAST DYNAMICS ANALYSIS PIPELINE (P1, AIM 1). THE TECHNOLOGY WILL THEN BE TESTED IN A LARGE, SINGLE CENTER (NORTHWESTERN) RETROSPECTIVE AORTA OUTCOMES STUDY (P1, AIM 2). THESE DEVELOPMENTS AND VALIDATION WILL PROVIDE THE FOUNDATION FOR PHASE 2 WHICH FOCUSES ON DEVELOPING OUR CLINICIAN-FACING CLOUD-BASED ANALYSIS PLATFORM AND REPORT (P2, AIM 1), PERFORMING A LARGE MULTICENTER RETROSPECTIVE VALIDATION AND OUTCOMES STUDY (P2, AIM 2), COMPLETING AN END-USER TCDFLOW EVALUATION (P2, AIM 3), AND SECURING FDA 510(K) CLEARANCE (P2, AIM 4). THE COMPLETION OF THE PHASE 1 AND 2 DELIVERABLES WILL RESULT IN AN FDA-CLEARED PRODUCT WHICH CAN BE READILY COMMERCIALIZED. ALL AIMS ARE DESIGNED WITH GUIDANCE FROM CONSULTANTS WITH DIRECT EXPERTISE IN FDA 510(K) CLEARANCE OF DIGITAL HEALTH PRODUCTS. THE TECHNOLOGY WILL PROVIDE IMPROVED PERSONALIZED RISK-STRATIFICATION OF AORTIC COMPLICATIONS BEYOND THE CURRENT SIMPLE AND INSUFFICIENT CLINICAL MEASURES. INCREASING OPERATIONAL EFFICIENCIES AND REDUCED HEALTH CARE UTILIZATION COSTS WILL BE ACHIEVED BY ACCESS TO CLOUD-BASED 4D HEMODYNAMIC ASSESSMENT BY A WIDE RANGE OF PATIENTS AND HEALTHCARE PROVIDERS WITHOUT THE NEED FOR HIGHLY SPECIALIZED IMAGING EQUIPMENT, TRAINING, AND EXPERTISE.

SBIR PHASE II: NOVEL, ACCURATE AND REPRODUCIBLE PLATFORM FOR THE DEVELOPABILITY ASSESSMENT OF PROTEIN THERAPEUTICS

ADVANCED DEVELOPMENT AND TESTING OF THE SUNRING HELIOSTAT

AERIAL SOLAR THERMAL RADIOMETRIC OBSERVER (''ASTRO'')

TAS::89 0222::TAS NEW PHASE I 2010 STTR; TITLE: ADVANCED METHODS FOR PREDICTING 3D UNSTEADY FLOWS AROUND WIND TURBINE BLADES; PI: GLEN WHITEHOUSE

REVISITING PIPE COMPONENT DESIGN

HYDRODYNAMIC CHIRALITY: A NOVEL METHOD FOR CHIRAL SEPARATION AND ANALYSIS

TREATMENT INTERVENTIONS FOR THE MENTAL HEALTH NEEDS OF WARFIGHTERS WITH TRAUMATIC BRAIN INJURY (TIME)

A PULSED CONDENSATION PARTICLE COUNTER FOR COST EFFECTIVE MONITORING OF ULTRAFINE AIRBORNE PARTICLES - A PULSED CONDENSATION PARTICLE COUNTER FOR COST EFFECTIVE MONITORING OF ULTRAFINE AIRBORNE PARTICLES ABSTRACT THIS PROJECT WILL DEVELOP AND VALIDATE A NEW APPROACH FOR AFFORDABLY MONITORING THE NUMBER CONCENTRATION OF ULTRAFINE AIRBORNE PARTICLES. ULTRAFINE PARTICLES ARE SPECIFICALLY IMPLICATED IN HEALTH, AND YET ARE NOT DETECTED BY LOWER-COST SENSORS. OUR APPROACH IS A PULSED CONDENSATION PARTICLE COUNTER THAT USES ADIABATIC EXPANSION COMBINED WITH SINGLE PARTICLE COUNTING. OUR PHASE I RESULTS DEMONSTRATE THAT THIS APPROACH IS RELIABLE OVER MONTHS OF CONTINUOUS OPERATION, WITH ±10% AGREEMENT WITH EXPENSIVE, RESEARCH-GRADE CONDENSATION PARTICLE COUNTERS. OUR TARGET IS AN AFFORDABLE PORTABLE INSTRUMENT, PRICED AT A FRACTION OF THE COST OF CURRENT INSTRUMENTS, THAT MEASURES THE PARTICLE NUMBER CONCENTRATION WITH KNOWN ACCURACY AND PRECISION. THE ENVISIONED COMMERCIAL INSTRUMENT WILL INCLUDE A COMMERCIAL OPTICAL COUNTER AND REPORT ULTRAFINE PARTICLE NUMBER CONCENTRATION AND ESTIMATED PM2.5 MASS. THIS PHASE II PROJECT WILL IMPROVE THE PERFORMANCE OF THE PHASE I SYSTEM, REFINE THE SUPPORTING COMPONENTS, AND INTEGRATE THE ELECTRONICS AND COMPONENTS INTO A COMPACT SYSTEM. THE COMPLETE PROTOTYPE SYSTEM WILL BE TESTED UNDER BOTH LABORATORY AND FIELD CONDITIONS. INSTRUMENT PRECISION AND ACCURACY OVER A RANGE OF PARTICLE SIZES AND CONCENTRATIONS WILL BE EVALUATED WITH MONODISPERSED, LABORATORY AEROSOLS, USING PARTICLE SIZES RANGING FROM 5 NM TO 2500 NM, AND CONCENTRATIONS FROM NEAR ZERO TO SEVERAL HUNDRED THOUSAND PER CUBIC CENTIMETER. INSTRUMENT ROBUSTNESS WILL BE EVALUATED THROUGH STRESS-TESTING AT EXTREMES IN TEMPERATURE (5°- 40°C) AND HUMIDITY (5%-95%). MONITORING PERFORMANCE AND STABILITY WILL BE TESTED THROUGH COMPARISON WITH COLLOCATED BENCHTOP INSTRUMENTS OVER WEEKS OF UNATTENDED OPERATION. MEASUREMENTS UNDER FIELD CONDITIONS WILL BE CONDUCTED IN COLLABORATION WITH A LOCAL UNIVERSITY EXPOSURE STUDY. VALIDATION AS A MONITOR WILL BE DONE IN COLLABORATION WITH AN AIR MONITORING DISTRICT. THE OBJECTIVE IS A COMPACT, COST-EFFECTIVE MONITOR WITH A PARTICLE DETECTION LIMIT BELOW 5 NM, WITH PRECISION OF ±10% FOR CONCENTRATIONS BETWEEN 10 - 104/CM3, AND PRECISION OF AT LEAST ±15% FOR CONCENTRATIONS REACHING 105/CM3, AND DATA RECOVERY OF AT LEAST 90%.

ADVANCED TROUGH WITH LOWER-COST SYSTEM-ARCHITECTURE (ATLAS)

CUBESAT: DYNAMIC IONOSPHERE CUBESAT EXPERIMENT (DICE)

STTR-PHASE I NEW; AN AEROSOL MOBILITY IMAGER FOR RAPID SIZE DISTRIBUTION MEASUREMENT; SUSANNE HERING

BIOCASCADE INLET - PROJECT SUMMARY RESPIRATORY INFECTIONS ARE THE MOST COMMON REASON FOR DOCTOR VISITS AND THE THIRD LEADING CAUSE OF DEATHS. VIRUSES ARE THE CAUSATIVE AGENTS OF MOST RESPIRATORY TRACT INFECTIONS. KNOWLEDGE OF THE TRANSMISSION MODES FOR PATHOGENIC RESPIRATORY VIRUSES IS CRITICAL FOR IMPROVING MITIGATION STRATEGIES THAT SAFEGUARD PUBLIC HEALTH, BUT UNDERSTANDING THEIR TRANSMISSION MECHANISMS IS HAMPERED BY EXISTING SAMPLING METHODS. SO FAR, NO METHOD HAS BEEN RECOMMENDED BY THE PUBLIC HEALTH ORGANIZATIONS FOR THE COLLECTION AND DETECTION OF AIRBORNE VIRUSES. THE LACK OF STANDARD PROTOCOLS RESULTS FROM THE FACT THAT NO SAMPLING PROCEDURE IS APPROPRIATE FOR SAMPLING OF ALL BIOAEROSOLS. DURING SAMPLING, IT IS NECESSARY TO MINIMIZE INACTIVATION OF MICROBES, SUCH AS INCAPACITATING DESICCATION AND DESTRUCTIVE IMPACTION UPON COLLECTION ONTO A COLLECTION SURFACE. WHEN COLLECTING SAMPLES FOR DETECTION OF VIRAL GENOMIC RNA OR DNA, MAINTAINING THE VIABILITY OF THE VIRUS IS NOT NECESSARY, BUT MAINTAINING NUCLEIC ACID INTEGRITY IS ESSENTIAL, ESPECIALLY FOR RNA, WHICH IS RAPIDLY DEGRADED UPON EXPOSURE TO THE ENVIRONMENT. FOR ASSESSING INFECTIVITY, THE PATHOGEN NEEDS TO BE VIABLE. IN BOTH CASES, GENTLE COLLECTION METHODS ARE REQUIRED. ALTHOUGH PREVIOUS EFFORTS HAVE TRIED TO SEPARATE VIRUS-CONTAINING PARTICLES BY AERODYNAMIC SIZE, MAINTAINING THEIR INFECTIVITY DURING SAMPLING REMAINS CHALLENGING. HERE, WE AIM TO DEVELOP A NOVEL SAMPLING SYSTEM, THE BIOCASCADE, THAT WILL ALLOW THE COLLECTION OF AIRBORNE VIRUSES WITHIN FOUR DIFFERENT BIOAEROSOL PARTICLE SIZE-FRACTIONS: >10 UM, PM4-10, PM1.5-4 AND PM1.5 INTO LIQUID MEDIUM, WHILE MAINTAINING INFECTIVITY OF THE VIRUSES THAT ARE COLLECTED. IN PHASE I, WE BUILT A BIOCASCADE PROTOTYPE. ITS PARTICLE SIZE-RANGE CUT-OFF AND THE COLLECTION EFFICIENCY OF EACH STAGE WERE MODELED AND DESIGNED BY NUMERICAL SIMULATIONS FOLLOWED BY VALIDATION THROUGH LABORATORY EXPERIMENTS USING NATIONAL INSTITUTES OF SCIENCE AND TECHNOLOGY (NIST)-CERTIFIED STANDARD- SIZED PARTICLES. ITS ABILITY TO COLLECT AND MAINTAIN THE INFECTIVITY OF BIOAEROSOL WAS THEN ASSESSED USING MICROORGANISMS THAT WERE REPRESENTATIVE OF THE SIZE RANGES THAT WOULD BE ENCOUNTERED IN BIOAEROSOLS. ALL PHASE-I AIMS WERE SUCCESSFULLY ACHIEVED. IN PHASE II, WE AIM TO IMPROVE OUR PROTOTYPE BY EXPANDING ITS CAPABILITIES, SUCH AS A COLD COLLECTION CHAMBER FOR PROVIDING A BETTER ENVIRONMENT FOR THE COLLECTED PATHOGENS, AND A CONTROL SYSTEM TO MAINTAIN THE LIQUID LEVEL THAT ENABLES INCREASED SAMPLING TIME TO SEVERAL HOURS. BY PROVIDING SIZE-FRACTIONATED AIR SAMPLES THAT CONTAIN INFECTIOUS PATHOGENS, THE BIOCASCADE IS ENVISIONED AS A POWERFUL TOOL, NOT AVAILABLE BEFORE, THAT CAN TRANSFORM OUR CURRENT DISEASE-CONTROL PARADIGM FROM A REACTIVE APPROACH (TO AN OUTBREAK AFTER ITS FACT) TO A PROACTIVE APPROACH (INFORM US THE FORTHCOMING VIRUSES).

NASSCO CONSISTENTLY SUPPORTS THE MISSION OF THE US NAVY, REPAIRING AND CONSTRUCTING VESSEL. NASSCO IS REQUESTING FUNDING TO INCREASE TRAINING AND ACQUIRE EQUIPMENT TO SUPPORT US NAVY REPAIR AVAILABILITIES. NASSCO IS PROPOSING PROJECTS TO INCREASE THE NUMBER OF TRADE EMPLOYEES AND OUR TECHNICAL SKILL AS A SHIPYARD. WITH GROWTH NASSCO ALSO IS PURSUING PROJECTS TO ENHANCE SHIPYARD SAFETY AND IMPROVE OUR ABILITY TO CONDUCT WORK ITEMS. NEW SAFETY EQUIPMENT IN PROPOSAL MODERNIZES OUR EMERGENCY VEHICLE FLEET AND EXPANDS THE CAPABILITIES . NEW TOOLING CUTS CYCLE TIME, IMPROVE QUALITY, AND MAXIMIZES THE WORK CONDUCTED ONBOARD EACH SHIP. ALL PROPOSED PROJECTS GIVE THE NASSCOS WORKFORCE THE TRAINING AND TOOLS TO SUCCEED IN US NAVY REPAIR. SUPPORTING THE DAILY FUNCTIONS OF THE WORKFORCE THROUGH MODERN EQUIPMENT AND TOOLS.

SBIR PHASE II: EFFICIENT MANUFACTURING OF NANOSTRUCTURED FLEXIBLE TRANSPARENT CONDUCTING ELECTRODES

FRACTAL GRAPH FRAMEWORK FOR AN EVOLVING GRID ARCHITECTURE

TWO DIMENSIONAL CHROMATOGRAPHY OF ATMOSPHERIC AEROSOLS: A NEW IN-SITU INSTRUMENT

LOW-COST, HIGH PERFORMANCE ELECTROCHROMIC DEVICES

FOIL GAS BEARING SUPPORTED HIGH SPEED CENTRIFUGAL BLOWER

SIZE-RESOLVED CHEMISTRY OF NEWLY-FORMED ATMOSPHERIC PARTICLES

RETRAINING NEURAL PATHWAYS TO IMPROVE COGNITIVE SKILLS AFTER A MILD TRAUMATIC BRAIN INJURY (MTBI) - RETRAINING NEURAL PATHWAYS IMPROVES COGNITIVE SKILLS AFTER A MILD TRAUMATIC BRAIN INJURY THIS STUDY SEEKS TO ADDRESS THE CHALLENGE OF HOW TO DELIVER TARGETED INTERVENTIONS THAT ADDRESS INDIVIDUALIZED COGNITIVE NEEDS OF MILD TRAUMATIC BRAIN INJURY (MTBI) PATIENTS. MTBIS ARE PREVALENT, WITH OVER 2.5 MILLION CONCUSSIONS OCCURRING IN THE U.S. EACH YEAR WITH ONLY 1 IN 6 OF THESE CONCUSSIONS BEING DIAGNOSED. MTBIS REPRESENT 80% OF TBIS. THE BULK OF MTBIS RESULT FROM MOTOR VEHICLE ACCIDENTS, FALLS, AND SITUATIONS INVOLVING SUDDEN ACCELERATION AND/OR DECELERATION OF THE HEAD, SUCH AS SPORTS INJURIES. A MTBI CAN RESULT IN SUBSTANTIAL COGNITIVE IMPAIRMENTS, WITH AN INABILITY TO RETURN TO WORK OR SCHOOL, AND LOW LEVELS OF SATISFACTION WITH ONE’S QUALITY OF LIFE. CURRENTLY, THERE ARE NO PROVEN SOLUTIONS TO REMEDIATE COGNITIVE DEFICITS PREVALENT IN THOSE WITH A MTBI. VISUAL TIMING DEFICITS ARE PERSISTENT IN INDIVIDUALS WITH A MILD TBI (MTBI), AND ARE THOUGHT TO BE DUE TO PROCESSING DEFICITS IN THE DORSAL PATHWAYS, AND ATTENTION AND EXECUTIVE CONTROL NETWORKS. THE PREMISE OF THE CURRENT PROPOSAL IS REHABILITATIVE TREATMENTS FOR THOSE WITH A MTBI FALL SHORT BECAUSE THESE TIMING ISSUES ARE NOT BEING ADDRESSED. TO ADDRESS THESE LIMITATIONS, WE DEVELOPED A MOVEMENT-DISCRIMINATION INTERVENTION (PATH TRAINING) THAT IS DESIGNED TO STIMULATE DORSAL MOTION PATHWAYS. PATH IS HYPOTHESIZED TO IMPROVE THE PRECISION IN TIMING OF VISUAL EVENTS, AND IN TURN IMPROVE COGNITIVE FUNCTIONS THAT RELY UPON VISUAL TIMING, SUCH AS WORKING MEMORY SPAN, A FUNCTION THAT IS COMMONLY IMPAIRED IN MTBI PATIENTS. THIS STUDY WILL PROVIDE CLINICAL TESTING OF THERAPEUTIC TRAINING FOR THE TREATMENT OF COGNITIVE DISORDERS CAUSED BY A MTBI. WE WILL EXTEND PREVIOUS RESULTS FROM A PILOT STUDY OF FOUR MTBI SUBJECTS TO A MUCH LARGER SAMPLE OF MTBI SUBJECTS. WE WILL DETERMINE THE FEASIBILITY OF AN INTERVENTION THAT REMEDIATES VISUAL TIMING DEFICITS TO IMPROVE VISUAL AND COGNITIVE DEFICITS IN MTBI MORE THAN A SHAM OR A CONVENTIONAL WORKING MEMORY TRAINING TASK. THE PROPOSED STUDY TESTS THE ABILITY OF PATH NEUROTRAINING TO IMPROVE VISUAL WORKING MEMORY, AND PROCESSING SPEED (PRIMARY OUTCOMES) AND AUDITORY WORKING MEMORY (WM), SELECTIVE ATTENTION, COGNITIVE FLEXIBILITY, SUSTAINED ATTENTION, READING SPEED, AND READING PROFICIENCY (SECONDARY OUTCOMES) IN MTBI SUBJECTS RAPIDLY AND EFFECTIVELY. WE PREDICT THAT PATH TRAINING IS MORE EFFECTIVE THAN EITHER CONVENTIONAL WM TRAINING OR SHAM TRAINING. THESE PREDICTIONS WILL BE EVALUATED BY BOTH PERCENTILE SCORES ON NEUROPSYCHOLOGICAL TESTS OF COGNITIVE FUNCTION, SCORES ON READING SPEED, READING PROFICIENCY, MOCA SCREENING TEST, AND QUESTIONNAIRES, AND MAGNETOENCEPHALOGRAPHY (MEG) BRAIN RECORDINGS FOR A SUBSET OF SUBJECTS IN TREATMENT GROUPS, PROVIDING A BIOMARKER, AS IS REQUIRED FOR COMMERCIALIZATION. MEG BRAIN RECORDINGS WILL BE USED TO DETERMINE WHETHER PATH NEUROTRAINING IMPROVES THE FUNCTION OF THE VISUAL MOTION, ATTENTION, AND WORKING MEMORY NETWORKS MORE THAN FOUND AFTER N-BACK WM TRAINING. MEG RECORDINGS WILL ALSO BE USED TO DETERMINE WHETHER PATH NEUROTRAINING STRENGTHENS COUPLED: 1) THETA/GAMMA ACTIVITY, AND 2) ALPHA/ GAMMA ACTIVITY. THERE IS A NEED TO PROVIDE A PROVEN SOLUTION FOR A MTBI BY DEVELOPING, AND MARKETING A RAPID AND EFFECTIVE TREATMENT SHOWN IN CLINICAL TRIALS TO IMPROVE COGNITIVE SKILLS.

CUBESAT: THE OPTICAL PROFILING OF THE ATMOSPHERIC LIMB (OPAL) CUBESAT EXPERIMENT

VALIDATING VEGETABLE PRODUCTION UNIT PLANTS USING CURRENTLY EXISTING FLIGHT RESOURCES

CHARACTERIZATION OF TOXICITY OF AIRBORNE ENMS USING DIRECT IN VITRO EXPOSURE

A MINIATURE MONITOR FOR TIME-RESOLVED AIRBORNE PARTICLE CHEMISTRY

SBIR PHASE II: DEVELOPMENT OF A MICROSCOPE TO DETECT CELLULAR MOTION IN THREE-DIMENSIONAL TISSUE

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT - IRA 24/31

ENHANCED IMAGING FOR VISUAL PROSTHESES - PROJECT SUMMARY/ABSTRACT THE PROPOSED PROJECT RELATES TO THE COMMERCIALIZATION OF A PROMISING NEW THERMAL/VISUAL IMAGING SYSTEM TO BE USED AS AN INPUT MODALITY TO VISUAL PROSTHESES AND OTHER LOW VISION AIDS. VISUAL PROSTHESES, INCLUDING SECOND SIGHT'S ARGUS® II RETINAL PROSTHESIS, WHICH RESTORES PARTIAL VISION TO PEOPLE BLINDED BY DISEASES SUCH AS RETINITIS PIGMENTOSA AND MACULAR DEGENERATION, AND SECOND SIGHT'S ORION® VISUAL CORTICAL PROSTHESIS, WHICH RESTORES PARTIAL VISION TO PEOPLE BLINDED BY DISEASES SUCH AS RETINITIS PIGMENTOSA, MACULAR DEGENERATION, GLAUCOMA, DIABETIC RETINOPATHY, EYE INJURY/TRAUMA, OPTIC NERVE DISEASE ETC., USE CAMERAS OR OTHER SENSORS TO PROVIDE ELECTRICAL STIMULATION DIRECTLY TO THE RETINA OR VISUAL CORTEX OF THE USER TO ELICIT VISUAL PERCEPTION. UNFORTUNATELY, ORDINARY LIGHT AND COLOR INFORMATION IS DIFFICULT FOR WEARERS TO EFFECTIVELY PROCESS IN MANY IMPORTANT TASKS WITH THE LIMITED PERCEIVED SPATIAL RESOLUTION OF THE PROSTHESES AND OTHER LOW VISION AIDS. CURRENT COMPENSATION TECHNIQUES IN REDUCED RESOLUTION SYSTEMS APPLY ENHANCEMENT, MAGNIFICATION, AND PANNING OF VISIBLE LIGHT IMAGERY, AND THESE TECHNIQUES HAVE UTILITY. HOWEVER, AS WE HAVE CONVINCINGLY DEMONSTRATED IN PHASES I AND II OF THE SBIR-SUPPORTED DEVELOPMENT PROJECT, OTHER TYPES OF IMAGING MORE NATURALLY ALIGN WITH THE LIMITED RESOLUTION OF VISUAL PROSTHESES IN IMPORTANT TASKS SUCH AS PEOPLE FINDING AND MOBILITY. IN THIS PROPOSED CRP PROJECT, WE WILL ADVANCE THE PHASE II DEVELOPED PRODUCTION-PROTOTYPE SYSTEM INTO COMMERCIAL PRODUCTION AND COMPLETE ALL REQUIRED VERIFICATION AND VALIDATION TESTING TO ACHIEVE FDA APPROVAL. COMPLETED PRODUCTION SYSTEMS WILL BE DISTRIBUTED TO PROSTHESIS RECIPIENTS WHO WILL UNDERGO TRAINING IN THEIR USE AND THEN BE ALLOWED TO EVALUATE THE SYSTEM IN THEIR HOME AND COMMUNITY ENVIRONMENT. THROUGH THESE EVALUATIONS THE END UTILITY OF THE SYSTEM IN REAL-WORLD USE WILL BE EVALUATED.

AN AUTOMATED SYSTEM TO LOCATE ITEMS MISPLACED BY PERSONS WITH DEMENTIA IN A CARE FACILITY

SBIR PHASE II: IMPLEMENTATION OF MACHINE LEARNING MODULE IN NOVEL RELAY TRUCKING PILOT -THE BROADER/COMMERCIAL IMPACT OF THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE II PROJECT WILL BE TO ENHANCE TRADITIONAL U.S. LONG-HAUL TRUCKING BY ELIMINATING COSTLY DOWNTOWN IN SUPPLY CHAINS, WHILE MAKING SIGNIFICANT ENVIRONMENTAL AND SOCIETAL IMPACTS. CURRENTLY, TRADITIONAL LONG-HAUL FREIGHT TRUCKING IS LIMITED TO CONVENTIONAL POINT-TO-POINT TRUCKING MODELS THAT REQUIRE EXCESSIVE IDLING, RESULTING IN OVER $3 BILLION ANNUALLY IN UNNECESSARY FUEL AND MAINTENANCE COSTS. MORE IMPORTANTLY, THESE INEFFICIENCIES CONTRIBUTE TO MENTAL AND PHYSICAL STRAINS ON TRUCK DRIVERS, EXACERBATING THE INDUSTRY'S SUSTAINABILITY ISSUES. WITH TRUCKING DEMAND PROJECTED TO INCREASE BY 36% BY 2031, THIS PROJECT'S RELAY MODEL AIMS TO SHIFT THE STATUS QUO BY ENHANCING ASSET UTILIZATION, EFFECTIVELY REDUCING DELIVERY TIMES BY 20-50%, WHILE LOWERING TRUCK DRIVER TURNOVER COSTS. TRANSFORMING TRUCKING INTO A LOCAL DAY JOB WILL SIGNIFICANTLY IMPROVE WORKING CONDITIONS, WHILE SECONDARILY SOLVING THE DRIVER RETENTION AND SHORTAGE CRISIS. MOREOVER, THE RELAY MODEL PROMISES ENVIRONMENTAL BENEFITS BY CUTTING EMISSIONS FROM IDLING AND EMPTY BACKHAULS WHILE FACILITATING THE ADOPTION OF BATTERY-POWERED FLEETS. THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE II PROJECT WILL BUILD UPON THE MACHINE LEARNING (ML) BASED MODULE SOFTWARE COMPONENT DEVELOPED IN PHASE I BY VALIDATING ITS ABILITY TO QUANTIFY IMPACTS OF DISRUPTION EVENTS IN LONG-HAUL RELAY TRUCKING, RESULTING IN A THOROUGH AND TIMELY RECOMMENDATION OF MITIGATION STRATEGIES. ACADEMIC RESEARCHERS HAVE USED SIMULATION, MATHEMATICAL PROGRAMMING, AND OTHER MODELING TECHNIQUES TO ESTABLISH THE THEORETICAL VIABILITY OF TRUCKING RELAY SYSTEMS TO SOLVE EQUIPMENT AND HUMAN CAPACITY ISSUES; HOWEVER, THESE MODELS HAVE RELIED ON SIMPLIFYING ASSUMPTIONS AND DO NOT ACCOUNT FOR COMMON DISRUPTION EVENTS THAT POSE A SIGNIFICANT OPERATIONAL CHALLENGE. QUANTIFYING THE IMPACTS OF POTENTIAL DISRUPTIONS ON TRAVEL TIME RELIABILITY WHILE RECOMMENDING TIMELY AND EFFECTIVE MITIGATION STRATEGIES TO DYNAMICALLY ADJUST DRIVER SCHEDULES IS ESSENTIAL TO REAL-WORLD DEPLOYMENT. THEREFORE, PHASE II CENTERS ON FOUR KEY OBJECTIVES: 1) REVISING AND INTEGRATING THE ML MODELS WITH REAL-TIME DATA STREAM APIS; 2) TESTING THE SCHEDULING ENGINE (WITH INTEGRATED ML MODELS) IN A SIMULATION ENVIRONMENT; 3) PILOTING THE SOFTWARE PLATFORM WITH LIVE TRUCKS AND DRIVERS ON THE ROAD; AND 4) ANALYZING KEY FINDINGS, INCORPORATING CHANGES, AND CREATING A FINAL REPORT AND REVISED PRODUCT ROADMAP. PROJECT LEARNINGS WILL TRANSLATE TO A PRACTICAL RELAY SOFTWARE PLATFORM TO PROPEL COMMERCIALIZATION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

SIZE-RESOLVED MEASUREMENT OF ULTRAFINE AND NANOMETER PARTICLE CONCENTRATIONS

DISTRIBUTED LOW POWER ON-BLADE CONTROL FOR WIND TURBINE LOAD MITIGATION

PROVISIONAL AWARD ENTITLED "ADVANCED MONOBORE CONCEPT CFEX SELF-EXPANDING TUBULAR TECHNOLOGY"

MINIATURE LOW-NOISE HIGH-QUALITY MRI PREAMPLIFIERS

ON-LINE MEASUREMENT OF THE CAPACITY OF AIRBORNE PARTICULATE MATTER TO GENERATE REACTIVE OXYGEN SPECIES

WEB-BASED PATIENT-REPORTED OUTCOMES (PRO) SYSTEM FOR BREAST CANCER SURVIVORS

IDENTIFYING OBJECTIVE MULTIMODAL PREDICTORS OF MILITARY/OPERATIONAL READINESS AND RECOVERY IN MILD TBI REHABILITATION. NEW AWARD.

A NIST/UTAH STATE UNIVERSITY RESEARCH FOUNDATION JOINT RESEARCH PROGRAM IN OPTICAL SENSOR CALIBRATION

LASER CUTTER TWO 5 TON BRIDGE CRANES

WE PROPOSE A SOUNDING ROCKET INVESTIGATION IN WHICH MULTIPLE SMALL SUB-PAYLOADS WILL BE DISPERSED FROM THE MAIN PAYLOAD AT HIGHVELOCITY FORMING AN EX

AN IN-SITU INSTRUMENT TO ASSESS THE CONCENTRATION AND PHASE PARTITIONING OF ATMOSHPERIC SEMI-VOLATILE ORGANIC COMPOUNDS

FOIL BEARING SUPPORTED HIGH SPEED CENTRIFUGAL CATHODE AIR BLOWER

MIRROR ENHANCED PLASMA SEPARATION PROCESS FOR PRODUCTION OF LARGE QUANTITIES OF ISOTOPES

FOIL GAS BEARING SUPPORTED HIGH TEMPERATURE CATHODE RECYCLE BLOWER

UTAH STATE UNIVERSITY RESEARCH FOUNDATION THE DEMONSTRATION OF MAJOR IMPROVEMENTS IN GAS FILTER RAD

CENTERS FOR INDEPENDENT LIVING - CENTERS FOR INDEPENDENT LIVING

ATHE PROJECT WILL FOCUS ON PERFORMING A HIGH-LEVEL SCREENING STUDY ASSESSMENT OF NEAR-TERM CSP TECHNOLOGIES THAT ARE OPTIMIZED TO ADDRESS CALIFORNIA’S SB100 CARBON REDUCTION GOALS. THE PROJECT TEAM WILL DEVELOP REFERENCE PLANT DESIGNS, CAPITAL AND O&M COST MODELS, AND PERFORMANCE MODELS FOR EACH CSP AND ALTERNATIVE TECHNOLOGY CONFIGURATION. THE GOAL WILL BE TO ENABLE INDIVIDUAL TECHNOLOGIES TO BE OPTIMIZED TO MEET THE MARKET OBJECTIVES AND THEN TO BE ABLE TO COMPARE THE COST AND PERFORMANCE OF TECHNOLOGIES ON A CONSISTENT BASIS. THE PROJECT WILL ALSO WILL FOCUS ON PERFORMING A MORE ACCURATE COST AND PERFORMANCE ASSESSMENT OF A SELECTED CSP TECHNOLOGY TO SUPPORT CALIFORNIA’S SB100 GOALS. THE PROJECT TEAM WILL DEVELOP HIGHER FIDELITY COST MODELS AND CONDUCT A MORE IN-DEPTH DESIGN OPTIMIZATION OF THE CSP PLANT CONFIGURATION. FINALLY, THE PROJECT WILL WORK TO DISSEMINATE INFORMATION FROM THE STUDY TO KEY STAKEHOLDER GROUPS.

DISPATCHABLE SOLAR POWER PLANT

DESIGNING LOW-COST, CUSTOMIZABLE HIGH-DENSITY PROBES FOR ACUTE AND CHRONIC NEURAL RECORDINGS IN RODENTS

INTEGRATED SPIN SYSTEM FOR PRODUCTION OF LARGE QUANTITIES OF STABLE ISOTOPES

FOIL GAS BEARING SUPPORTED HIGH TEMPERATURE CATHODE RECYCLE BLOWER

SEE SCHEDULE

STTR PHASE II: SPIDERRADIO: ENABLING COGNITIVE DYNAMIC SPECTRUM ACCESS WIRELESS COMMUNICATIONS

ADVANCED ELECTROSTATIC COMPUTATION IN MOLECULAR DYNAMICS

"FY08 CONGRESSIONAL EARMARK FOR SPACE DYNAMICS LABORATORY CALIBRATION STANDARDS INITIATIVE"THERE IS A NEED TO IMPROVE THE RADIOMETRIC CALIBRATION TR

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** IMPLEMENTATION OF RELAY TRUCKING SOFTWARE AND INFRASTRUCTURE TO BENEFIT RURAL WORKFORCE

AN AUTOMATED SYSTEM FOR CAREGIVERS AND STAFF TO LOCATE ITEMS MISPLACED BY PERSONSWITH DEMENTIA IN A CARE FACILITY - PROJECT SUMMARY/ABSTRACT THIS PROPOSAL DIRECTLY ADDRESSES THE NIH'S CURRENT INTEREST IN TECHNOLOGIES THAT IMPROVE HEALTH SERVICE DELIVERY, MANAGEMENT AND QUALITY, AND DIGITAL APPROACHES TO IMPROVE HEALTHCARE SERVICES AT MEMORY CARE CENTERS, LONG TERM CARE FACILITIES (LTCF)S AND HEALTHCARE PROVIDERS. THIS PHASE II PROJECT WILL DEVELOP AN AUTOMATED ULTRA- WIDE BAND (UWB) BASED SYSTEM FOR CAREGIVERS AND STAFF TO EASILY LOCATE ITEMS MISPLACED BY PERSONS WITH DEMENTIA (PWD) OR PERSONS WITH MEMORY CONCERTS (PWMC) IN LTCFS. LOSS OF ITEMS IS A RECURRING CHALLENGE IN LTCFS. INDIVIDUALS WITH DEMENTIA AND COGNITIVE DECLINE ARE MORE LIKELY TO HIDE ITEMS, FORGET ITEM LOCATION, AND UNINTENTIONALLY TAKE ITEMS THAT DO NOT BELONG TO THEM RESULTING IN ITEM LOSS. DEMENTIA PATIENTS NECESSITATE ROUND-THE-CLOCK CARE BY DIRECT CARE WORKERS (DCWS) IN MEMORY CARE FACILITIES. IN THESE SETTINGS, HIDING AND HOARDING OF PATIENTS ENTAIL CONSIDERABLE ADDITIONAL BURDEN FOR DCWS. HIDING AND HOARDING INVOLVES LOSING TRACK OF POSSESSIONS, LOSING TRACK OF IMPORTANT TOOLS REQUIRED FOR DAILY FUNCTIONING, OR HIDING VALUABLE ITEMS FOR FEAR OF HAVING THEM STOLEN. RESEARCH, INCLUDING WORK FROM OUR OWN SUCCESSFUL PHASE I PROJECT, SHOWS THAT DCWS AND STAFF RELY ON DEVICES TO PROVIDE SEAMLESS CARE TO PERSONS WITH DEMENTIA (PWD) AND WHEN THOSE ITEMS GO MISSING, EVEN BRIEFLY, THE RESULT CAN BE DISTRESS FOR DCWS, INCREASED CARE BURDEN, AND CARE INTERRUPTIONS. HIDING AND HOARDING RESULTS IN THE LOSS OF PATIENTS' EXPENSIVE, NECESSARY OR EMOTIONALLY VALUABLE PERSONAL EFFECTS, THEREBY INCREASING DCW WORKLOAD AND UNDERMINING EFFECTIVE AND EFFICIENT PROVISION OF CARE. THERE IS A CRITICAL NEED TO DEVELOP NOVEL TECHNOLOGIES TO MITIGATE THE COSTS OF HOARDING AND HIDING; LIMITING RUMMAGING OR ACCUSATIONS OF THEFT, LIMITING THE NEED FOR EXTRA STAFFING, AND CONTRIBUTING TO MORE EFFECTIVE MEMORY CARE DELIVERY IN INSTITUTIONAL CARE SETTINGS. RESULTS FROM OUR SUCCESSFUL PHASE I PROJECT SHOWED UNIVERSAL APPROVAL OF THE PROPOSED UWB SYSTEM WITH DCWS PROVIDING INSIGHTS NOT ONLY INTO THE PROPOSED TECHNOLOGY FEATURES, BUT ALSO THE TYPES OF ITEMS COMMONLY LOST IN CARE SETTINGS, THE ADVERSE IMPACTS OF ITEM LOSS, USEFUL ADDITIONS TO THE PROPOSED TAG TECHNOLOGY, AND TIPS ON SUCCESSFUL IMPLEMENTATION IN A CARE SETTING. THE PROPOSED PHASE II PROJECT WILL BUILD ON THE SUCCESS OF THE PHASE I PROTOTYPE WITH INNOVATIVE FEATURES THAT SIGNIFICANTLY ENHANCE THE UWB SYSTEM'S HARDWARE FORM FACTOR, SET-UP, OPERATION, LOCATION PRECISION, FUNCTIONALITY, ROBUSTNESS, SECURITY AND USABILITY. MEMORY CARE CENTERS AND LTCFS WHO SERVE PWD, WILL BE THE INITIAL TARGET MARKET SEGMENT FOR THIS PRODUCT.

OPTIMIZATION OF ROOT ZONE SUNSTRATES FOR REDUCED GRAVITY EXPERIEMENTS

SBIR PHASE II: AUTOMATED CULTURE AND DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS

SBIR PHASE II: BISTABLE ELECTROFLUIDIC DEVICE FOR HIGH-BRIGHTNESS ELECTRONIC PAPER

TRACTOR-BASED REAL-TIME SYSTEM FOR DRIFT REDUCTION AND DISPOSITION PREDICTION

NOVEL THIODERIVATIVES AS NEUROPROTECTIVE ANTICONVULSANTS

TRUCK SECURITY GRANT PROGRAM

FULLY INTEGRATED AUTOMOTIVE TRACTION INVERTER WITH REAL-TIME SWITCHING OPTIMIZATION - NEW AWARD TO AZURE DYNAMICS, INC. (BASE AWARD - AMENDMENT 000)

SBIR PHASE II: LENS-FORMING NANOCOMPOSITES FOR HIGH STRENGTH, CLEAR OPHTHALMIC LENSES

BIOGAS FUELED SOLID OXIDE FUEL CELL STACK

FY09 EARMARK ENTITLED, `TO PROVIDE TECHNICAL SUPPORT TO THE SATELLITE SENSOR CALIBRATION TEAM FOR THE GLOBAL CLIMATE OBSERVING SYSTEM THERE IS A NEE

RELIABILITY AND ENDURANCE TESTING OF HIGH PRESSURE HEAT EXCHANGES TO RECOVER AND CONVERT LOCOMOTIVE ENGINE WASTE ENERGY

THE SOUNDMIND SMART AMPLIFIER: AN AFFORDABLE, ACCESSIBLE, USER-FRIENDLY HEARING SOLUTION FOR PERSONS WITH MEMORY CONCERNS AND THEIR FAMILY CAREGIVERS - ABSTRACT HEARING LOSS AND MEMORY CONCERNS ARE PREVALENT HEALTH ISSUES AMONG AMERICAN OLDER ADULTS, SIGNIFICANTLY AFFECTING THEIR QUALITY OF LIFE. TWO-THIRDS OF AMERICANS AGED 70 AND OLDER EXPERIENCE AUDIOMETRIC HEARING LOSS AND ONE-THIRD SUFFER FROM CLINICALLY SIGNIFICANT COGNITIVE IMPAIRMENT, INCLUDING DEMENTIA. WHEN THESE CONDITIONS CO-OCCUR, THEIR EFFECTS ON COMMUNICATION AND SOCIAL ENGAGEMENT ARE COMPOUNDED, LEADING TO INCREASED ISOLATION AND DECREASED QUALITY OF LIFE. HEARING AMPLIFICATION TECHNOLOGY CAN MITIGATE THESE EFFECTS BY ENHANCING SPEECH AUDIBILITY AND REDUCING COGNITIVE LISTENING EFFORT, THEREBY IMPROVING COMMUNICATION AND SOCIAL ENGAGEMENT. DESPITE THESE BENEFITS, ONLY 30% OF PEOPLE WITH MEMORY CONCERNS (PWMC) USE HEARING AIDS DUE TO BARRIERS SUCH AS COST, ACCESS, AND THE COMPLEXITY OF CURRENT HEARING AID TECHNOLOGY. EXISTING HEARING TECHNOLOGY FAILS TO MEET THE SPECIFIC NEEDS OF PWMC AND THEIR CAREGIVERS. THE RECENT INTRODUCTION OF OVER-THE-COUNTER (OTC) HEARING AIDS BY THE FDA ADDRESSES SOME COST AND ACCESS ISSUES, BUT LEAVES OTHER ISSUES UNADDRESSED. CURRENT HEARING AIDS, WHETHER OTC OR PRESCRIPTION, OFTEN INVOLVE COMPLEX HANDLING AND PROGRAMMING, WHICH PWMC FIND CHALLENGING. THIS INCREASES DEPENDENCE ON CAREGIVERS, WHO ALREADY FACE SIGNIFICANT BURDENS. AN ALTERNATIVE OPTION IS PERSONAL SOUND AMPLIFICATION PRODUCTS (PSAPS) IN THE FORM OF EAR-LEVEL AMPLIFIERS AND LARGER “POCKETALKERS” MANY OF THESE DEVICES AIM TO ADDRESS USABILITY CONCERNS BUT LACK THE EVIDENCE-BASED AUDIO PROFILES AND ADVANCED CONNECTIVITY FEATURES CONTAINED IN HEARING AIDS. IMPORTANTLY, TO OUR KNOWLEDGE, NO AVAILABLE HEARING DEVICE INTEGRATES EVIDENCE-BASED SOUND THERAPIES THAT HAVE BEEN SHOWN TO BENEFIT PWMC, NOR DO THEY INCLUDE A CAREGIVER-FACING MOBILE APPLICATION SPECIFICALLY DESIGNED FOR CAREGIVERS OF PWMC. TO ADDRESS THESE GAPS, WE PROPOSE DEVELOPING THE SOUNDMIND ASSISTIVE HEARING SYSTEM, A SMART AMPLIFIER SPECIFICALLY DESIGNED TO MEET THE NEEDS OF PWMC AND THEIR FAMILY CAREGIVERS. THIS SYSTEM WILL FEATURE AN INTUITIVE DESIGN WITH LARGER, EASY-TO-HANDLE PARTS AND USES FAMILIAR CONSUMER HEADPHONES TO PROMOTE COMFORT AND ENSURE EASE OF USE. IT WILL INCLUDE A CAREGIVER-ENABLED SMARTPHONE APPLICATION FOR REMOTE ASSISTANCE AND INCORPORATE CUSTOMIZED AUDITORY REMINDERS AND MUSIC THERAPY, BOTH OF WHICH HAVE BEEN SHOWN TO BENEFIT PWMC, BUT WHICH HAVE NOT YET BEEN INCORPORATED INTO HEARING AMPLIFICATION. THE SOUNDMIND SYSTEM AIMS TO IMPROVE THE QUALITY OF LIFE FOR PWMC BY FACILITATING EASIER USE OF HEARING TECHNOLOGY, THEREBY PROMOTING SOCIAL ENGAGEMENT, COGNITIVE HEALTH, AND OVERALL WELL-BEING WHILE REDUCING CAREGIVER BURDEN.

SYSTEM TO ALLOW OFF SITE MONITORING OF PRESSURE ULCERS FOR PATIENTS IN A RURAL LONG-TERM CARE FACILITY - ABSTRACT THIS PHASE I WILL SHOW THE FEASIBILITY OF AN IMAGING INSTRUMENT TO ASSIST AN INDIVIDUAL CAREGIVER IN MONITORING DEEP PRESSURE TISSUE INJURIES (DPTIS). PATIENTS THAT ARE IMMOBILE, ARE INSENSATE, CHOOSE TO NOT MOVE CAN DEVELOP PRESSURE ULCERS (PUS). THESE PUS SHOULD BE EXAMINED FOR THEIR SKIN INTEGRITY ON A FREQUENT BASIS. THIS PROJECT WILL DEVELOP A SYSTEM TO ALLOW AN UNTRAINED CAREGIVER TO COLLECT VISUAL AND THERMAL IMAGES THAT PROVIDE REMOTE WOUND ASSESSMENT. THE CAPTURE OF BOTH VISUAL AND THERMAL IMAGES PROVIDES THE BENEFIT OF WOUND ASSESSMENT FOR PATIENTS WITH DIFFERENT SKIN TONES INCLUDING DARKLY PIGMENTED SKIN. FOR THE INDIVIDUAL CAREGIVER THE PRACTICAL PROCESS OF OBTAINING A DIGITAL IMAGE IS VERY DIFFICULT BECAUSE THEY NORMALLY WOULD USE BOTH HANDS TO REPOSITION THE PATIENT TO GET A GOOD FIELD-OF-VIEW OF THE PU. IN LOW-INCOME RURAL NURSING HOMES WITH MINIMAL STAFF, THEY MAY NOT HAVE THE ABILITY TO BOTH POSITION A PATIENT INTO A NATURAL LIGHT SETTING AND TO OPERATE THE CAMERA. THE INNOVATION IS TO COMBINE A VERY MINIATURE THERMAL IMAGE CAMERA AND VISIBLE IMAGE CAMERA ON A LOW-COST HEAD MOUNTED DISPLAY. THIS WILL ALLOW ONE CAREGIVER TO POSITION THE PATIENT, AIM THE IMAGER AND ACQUIRE THE NEW IMAGE OF THE PU FOR REMOTE ASSESSMENT. A SMARTPHONE CONNECTED WITH THE HEAD- MOUNTED DISPLAY WOULD SEND THE IMAGES TO A WOUND SPECIALIST FOR THE REMOTE CLINICAL ASSESSMENT.

DEVELOPMENT OF A HADAMARD TRANSFORM TIME-OF-FLIGHT MASS SPECTROMETER FOR OBSERVATIONS OF THE MESOSPH

ENVIRONMENTAL MANAGEMENT OF MILITARY SYSTEMS: THE USE OF LIFE-CYCLE ASSESSMENT FOR SUSTAINABLE PLANNING

SBIR PHASE II: ACTIVE VISIBLE AND INFRARED MANAGEMENT FOR MORE ENERGY EFFICIENT BUILDINGS

ESTIMATED TOTAL FUNDS REFER TO THE FUNDS AVAILABLE FOR CASH GRANTS WHILE ESTIMATED NUMBER OF GRANTS EQUALS TOTAL OF ALL AMERICORPS VISTA PROJECTS, TH

THE PRINCIPLE SCOPE ELEMENTS ARE TO 1) REVIEW THE EXISTING DESIGN BASIS DOCUMENTS, 2) MODIFY THOSE PORTIONS OF THE DESIGN BASES WHICH HAVE CHANGED OR ADVANCED DURING THE PAST 20 YEARS, 3) DEVELOP A NEW DRAFT DESIGN BASIS DOCUMENT, AND 4) SHARE THE DRAFT WITH INDUSTRY PARTICIPANTS TO SOLICIT COMMENTS AND RECOMMENDATIONS TOWARD AN INDUSTRY CONSENSUS.

DOMINATING THE CUMULATION EFFICIENCY OF PBX-DRIVEN LINERS IN SHAPED CHARGES: FROM THE CONVERGENT MOTION UP TO THE JET FORMATION

CARES ACT INSTITUTION PORTION

CARES ACT EMERGENCY GRANT FUNDING

DEVELOPMENT OF INSTRUMENTS FOR MEASUREMENT OF PARTICULATES AND GASES FROM AGRICULTURAL OPERATIONS

THERE IS A NEED TO IMPROVE THE RADIOMETRIC CALIBRATION TRACEABILITY OF SPACE-BASED SENSORS TO THE PRIMARY NATIONAL STANDARDS DEVELOPED BY THE NATIONA

APP-ASSISTED DAY RECONSTRUCTION TO REDUCE TREATMENT BURDEN AND LOGISTIC TOXICITY IN CANCER PATIENTS - PROJECT SUMMARY EACH YEAR, MORE THAN 1.7 MILLION NEW CANCER PATIENTS IN THE U.S. UNDERGO INTENSE, MULTIMODAL TREATMENTS THAT THAT CREATE NUMEROUS LOGISTICAL CHALLENGES IN MANAGING TREATMENT AND EVERYDAY LIFE PRIORITIES. IN THE CURRENT CANCER CARE SYSTEM, “LOGISTIC TOXICITY”—THE TOXIC EFFECTS IMPOSED BY THE LOGISTICAL BURDEN OF CARRYING OUT CANCER TREATMENT-RELATED TASKS ON PATIENT WELL-BEING—HAS BEEN LARGELY UNMEASURED AND UNADDRESSED. CURRENT METHODS FOR MEASURING LOGISTIC TOXICITY GENERATE RETROSPECTIVE ASSESSMENTS INTENDED FOR RESEARCHERS. THEY DO NOT OFFER TIMELY INFORMATION THAT EMPOWER PATIENTS TO SOLICIT ASSISTANCE FROM CARE PROVIDERS, EMPLOYERS, FAMILY, AND FRIENDS. NOR DO THEY EMPOWER PROVIDERS TO EXPLORE THE INCREASINGLY AVAILABLE TREATMENT OPTIONS FOR PATIENT- CENTERED CANCER CARE. THIS PROPOSAL AIMS TO APPLY A NEW METHOD—APP-ASSISTED DAY RECONSTRUCTION—TO DEVELOP THE FIRST DIGITAL HEALTH TOOL TO ENABLE REMOTE PATIENT MONITORING OF LOGISTIC TOXICITY, WHICH IS THE NECESSARY FIRST STEP TOWARDS DEVELOPING EFFECTIVE CARE INTERVENTIONS FOR ADDRESSING IT. OUR PRODUCT IS BOTH CONCEPTUALLY AND TECHNICALLY INNOVATIVE. CONCEPTUALLY, WE APPLY THE DAY RECONSTRUCTION METHOD—A METHOD INITIALLY CREATED BY WELL-BEING RESEARCHERS FOR COLLECTING MORE ACCURATE DATA ON DAILY LIFE EXPERIENCES—TO COLLECT ACTIVITY ENGAGEMENT AND WELL-BEING INFORMATION RELATED TO CANCER TREATMENT TASKS. TECHNICALLY, WE LEVERAGE OUR EXISTING PATENTED TECHNOLOGY AND NEW MACHINE LEARNING TECHNIQUES TO ENABLE NOVEL INTEGRATION OF OBJECTIVE MOBILE SENSING WITH SUBJECTIVE PATIENT INPUT. MOBILE SENSING AND MACHINE LEARNING WILL CONSTITUTE THE “ASSIST” THAT THE APP PROVIDES FOR DAY RECONSTRUCTION IN RELATION TO LOGISTIC TOXICITY, SIGNIFICANTLY REDUCING RECALL ERRORS AND THE NEED FOR MANUAL INPUT. THE “ASSIST” WILL ALSO PROMPT PATIENTS TO PROVIDE INFORMATION SUCH AS SUBJECTIVE WELL-BEING RATINGS THAT ARE NOT DETECTABLE BY MOBILE SENSING OR MACHINE LEARNING, GENERATING MORE ACCURATE AND COMPREHENSIVE MEASURES OF LOGISTIC TOXICITY THAN EXISTING METHODS. THE PROJECT HAS THREE SPECIFIC AIMS, INCLUDING (1) AN INITIAL SYSTEM DESIGN BASED UPON INPUT FROM CANCER PATIENTS AND CANCER CARE STAKEHOLDERS, (2) PROTOTYPE DEVELOPMENT AND INITIAL TESTS, AND (3) FIELD TESTS OF THE APP AMONG 60 DIVERSE PATIENTS UNDERGOING TREATMENT FOR CANCER. IN AIM 3, PATIENTS WILL RATE THE QUALITY OF THE APP USING THE MOBILE APP RATING SCALE (MARS) AND THEIR SATISFACTION WITH THE THREE KEY APP FEATURES: 1) THE APP’S ABILITY TO CAPTURE OUT-OF-HOME TREATMENT-RELATED ACTIVITIES AND TRIPS, 2) THE EASE OF THE INTERFACE FOR INPUTTING HOME-BASED TREATMENT-RELATED ACTIVITIES AND WELL-BEING RATINGS, AND 3) THE USEFULNESS OF THE LOGISTIC TOXICITY SUMMARY REPORT. THE OUTCOME OF THIS PROJECT WILL BE A FINAL PROTOTYPE APP WITH 70% OF PATIENTS INDICATING AN OVERALL MARS SCORE OF 4.0 OR MORE AND SATISFACTION WITH THE THREE FEATURES. IN PHASE II, THE TEAM WILL TEST THE EFFICACY OF THE APP—BOTH SEPARATELY AND IN CONJUNCTION WITH CARE COORDINATION, TELEMEDICINE, AND HOME-BASED TREATMENTS—IN REDUCING LOGISTIC TOXICITY AND IMPROVING TREATMENT OUTCOMES IN A RANDOMIZED CONTROLLED TRIAL.

INNOVATIVE PNEUMOTHORAX DECOMPRESSION DEVICE - PROJECT SUMMARY/ABSTRACT THE PROPOSED PROJECT RELATES TO THE DEVELOPMENT OF AN INNOVATIVE, SINGLE-OPERATOR PNEUMOTHORAX DECOMPRESSION DEVICE THAT AIMS TO IMPROVE THE SAFETY AND TIME EFFICIENCY OF THERAPEUTIC DECOMPRESSION. THE AIM OF NEONATAL PNEUMOTHORAX DECOMPRESSION IS TO ALLEVIATE BUILT-UP AIR POCKETS INSIDE THE CHEST WALL THAT THREATEN THE FUNCTIONALITY OF VITAL ORGANS. CURRENT PROCEDURES REQUIRE A MEDICAL PROVIDER TO ASSEMBLE A FUNCTIONAL DECOMPRESSION “DEVICE” USING MULTIPLE OFF-THE-SHELF MODULAR COMPONENTS, WHICH CAN BE INEFFICIENT AND TIME CONSUMING IN EMERGENCY SITUATIONS. TWO MEDICAL PROVIDERS ARE GENERALLY REQUIRED TO ACHIEVE THE THERAPY, WHICH INVOLVES INSERTION OF A NEEDLE INTO THE CHEST WALL WITH NO FEEDBACK OF NEEDLE DEPTH. IN ADDITION, THE NEEDLE IS SUBJECT TO MOVEMENT, POTENTIALLY HARMING SURROUNDING LUNG TISSUE, AS STABILITY OF THE NEEDLE WITHIN THE CHEST CAVITY IS BASED SOLELY ON PROVIDER SKILL AND STEADINESS. AN INNOVATIVE PROTOTYPE DEVICE WILL BE DESIGNED, MANUFACTURED AND EVALUATED.

TAS::57 3600::TAS 'PLASMUT - NONEQUILIBRIUM GAS-SURFACE INTERACTIONS AT HIGH TEMPERATURE'

TAS::57 3600::TAS INVESTIGATION OF THERMAL NON-EQUILIBRIUM EFFECTS IN RAPID FLOW EXPANSIONS

(YIP FY08) PRELIMINARY STUDIES FOR UTILIZING CRYOGENIC MAGNETOHYDRODYNAMICS IN MULTI-FUNCTIONAL ELECTRO/MECHANICAL SYSTEMS

R&D, SCIENCE AND ENGINEERING, IN THE AREA OF AERONAUTICAL

CONTROLLING THE INITIATION SENSITIVITY AND THE DETONATION PERFORMANCE OF CRYSTALLINE EXPLOSIVES SUBJECTED TO SHOCK OR IMPACT

MEASUREMENT AND MODELING OF FUGITIVE DUST FROM OFF-ROAD DOD ACTIVITIES

RAPID HEART ATTACK DETECTION USING AN AC ELECTROKINETIC DEVICE

FUNDAMENTAL STUDIES IN CLOUD SCATTERING AND MODELING FOR ENVIRONMENTAL AND DEFENSE APPLICATIONS

LOCOMOTIVE WASTE HEAT RECOVER SYSTEM INTEGRATION, SAFETY AND FIELD DEMONSTRATION (PHASE III)

SBIR-PHASE I NEW; NO-VIBRATION AGILE CRYOGENIC OPTICAL REFRIGERATOR; RICHARD EPSTEIN

OPTIMIZATION OF PARABOLIC TROUGH OPERATIONS & MAINTENANCE (OPTOM)

ALGORITHMS TO DETECT IN-HOME FALLS OF ELDERLY USING STRUCTURED LIGHT SENSING

SMARTPHONE MACHINE LEARNING SPEECH ENHANCEMENT SYSTEM FOR HEARING AID DEVICES FOR THE UNDERSERVED AND RURAL POPULATIONS - ABSTRACT THIS PROPOSAL RESPONDS DIRECTLY TO THE PURPOSE OF THE RFA-MD-23-003 SBIR FUNDING OPPORTUNITY ANNOUNCEMENT (FOA). NEARLY 44 MILLION AMERICANS EXPERIENCE HEARING LOSS, BUT AS MUCH AS 86% OF ADULTS WHO COULD BENEFIT FROM HEARING AID DEVICES (HAD) DO NOT USE THEM. UNTREATED HEARING LOSS IS ALMOST TWICE AS PREVALENT IN RURAL AREAS. MORE THAN 46 MILLION PEOPLE LIVE IN RURAL AMERICA, BUT THESE COMMUNITIES FACE SIGNIFICANT BARRIERS AND DELAYS IN ACCESSING CARE AND EXPERIENCE A LACK OF PROVIDERS FOR AUDIOLOGY SERVICES. THE AVERAGE RETAIL PRICE OF HADS WAS $4,700, MAKING IT PROHIBITIVELY EXPENSIVE FOR THE RURAL AND MINORITY POPULATIONS WHO HAVE LOWER INCOMES. HEARING LOSS IS ALSO HIGHLY PREVALENT IN BLACK AND LATINO/HISPANIC COMMUNITIES AND GROWING, BUT OLDER BLACK ADULTS WERE 58% AND MEXICAN AMERICAN OLDER ADULTS WERE 78% LESS LIKELY TO USE HADS, DUE TO REASONS OF HIGH COST AND LACK OF INSURANCE COVERAGE. ASIDE FROM COST, CONCERNS ABOUT COMFORT, EFFECTIVENESS AND SATISFACTION ARE THE OTHER SIGNIFICANT BARRIERS TO HAD USAGE. THE FDA MADE OVER-THE-COUNTER (OTC) HADS A REALITY IN 2022, CREATING A NEW HEARING OPTION FOR MANY ADULTS WITH PERCEIVED MILD TO MODERATE HEARING LOSS. THE INTRODUCTION OF OTC HADS IS SET TO INCREASE ACCESSIBILITY AND AFFORDABILITY OF HEARING CARE FOR UNDERSERVED POPULATIONS. A COMMON COMPLAINT OF HAD USERS IS THE HAD INABILITY TO REDUCE AMBIENT BACKGROUND NOISE COMPLETELY, INSTEAD, THE BACKGROUND NOISE IS AMPLIFIED ALONG WITH THE HUMAN VOICE. SPEECH ENHANCEMENT ALGORITHMS CONTINUE TO BE DEVELOPED AND THE MOST ADVANCED FOUND ON HIGH-END COSTLY HAD PLATFORMS. THIS PROJECT WILL DEVELOP MACHINE LEARNING (ML) BASED SMARTPHONE SOFTWARE WITH A GRAPHICAL USER INTERFACE (GUI), TO BRING THESE ADVANCED SPEECH ENHANCEMENT AND NOISE REDUCTION ALGORITHMS TO THE OTC HAD USERS. WITH SMARTPHONE ASSISTIVE SOFTWARE AND THE PREDICTIVE POWER OF ML, OUR PROPOSED SOLUTION TO REDUCE BACKGROUND NOISE AND ENHANCE SPEECH, WILL SIGNIFICANTLY IMPROVE OTC HAD ACCESSIBILITY, AFFORDABILITY, AND ACCEPTANCE, THUS BENEFITTING THE RURAL AND MINORITY POPULATIONS THE MOST.

INTEGRATION OF IMMUNOCHEMICAL GENOMIC & TRANSCRIPTOMIC ANALYSES OF HUMAN SKIN

RING WEARABLE SENSOR USE FOR DIAGNOSIS AND MONITORING OF PARKINSON'S DISEASE IN UNDERSERVED RURAL POPULATIONS - ABSTRACT THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP AN INNOVATIVE RING SENSOR SYSTEM, TO BE WORN ON THE FINGER, FOR THE DIAGNOSIS AND MONITORING OF PARKINSON'S DISEASE (PD) IN UNDERSERVED RURAL POPULATIONS. RURAL REGIONS OF THE US HAVE BEEN OBSERVED TO BE DISPROPORTIONATELY IMPACTED BY PD DUE TO HIGHER RATES OF DIAGNOSIS, WHILE ALSO LACKING ACCESS TO NEUROLOGISTS AND OTHER ALLIED HEALTH PROFESSIONALS, WHO ARE OVERCONCENTRATED IN URBAN AREAS WITH ACADEMIC MEDICAL CENTERS. AS A RESULT, RURAL PWPD MAY BE DIAGNOSED LATER IN THE DISEASE PROCESS AND HAVE FEWER SPECIALTY CARE VISITS WHICH LEADS TO INCREASED HOSPITALIZATIONS, MORBIDITY AND DECREASED QUALITY OF LIFE. THE PROPOSED INEXPENSIVE, EASY-TO-USE RING CAN BE WORN DAILY, ADJUSTABLE TO ANY FINGER AND USED TO SUPPORT BOTH EARLY DIAGNOSIS AND ONGOING SYMPTOM MANAGEMENT. THIS RING COULD BE USED AS A SCREENING TOOL TO DETECT PD AND ALERT PRIMARY CARE PHYSICIANS (PCP) MUCH EARLIER THAN TYPICAL. IT COULD ALSO BE USED AS A TOOL TO AID IN THE REMOTE MANAGEMENT OF PD AS MOVEMENT DISORDER SPECIALISTS COULD USE THE DATA TO ASSESS MEDICATION TIMING AND MANAGEMENT OR DEEP BRAIN STIMULATION (DBS) PROGRAMMING SETTINGS. THE PROPOSED SYSTEM IS DESIGNED WITH A RURAL LOW-INCOME USER IN MIND. NO INTERNET CONNECTION OR SMARTPHONE/COMPUTER TECHNOLOGY IS REQUIRED. WEARABLE SENSORS FOR MEDICAL USE IN PD PATIENTS ARE PLAGUED WITH USABILITY CONCERNS, MANY FOCUSED ON THE STIGMA ASSOCIATED WITH WEARING THEM IN PROMINENT LOCATIONS. THEY ALSO TYPICALLY REQUIRE A SMARTPHONE, APP AND/OR INTERNET CONNECTIVITY WHICH MAY LIMIT THEIR APPLICABILITY FOR RURAL POPULATIONS. THERE IS THEREFORE A NEED FOR A DISCREET DEVICE WITHOUT THE NEED FOR INTERNET CONNECTIVITY TO BE USEFUL FOR RURAL PWPD. NEWLY AVAILABLE ULTRAMINIATURE HIGH-CAPACITY CURVED BATTERY AND IMU TECHNOLOGIES MAKE THE PROPOSED RING TECHNICALLY FEASIBLE AT THIS TIME.

THIS PROPOSAL ADOPTS A NEW APPROACH TO OPTIMAL TRAJECTORY DESIGN THAT CONSIDERS UNCERTAINTIES IN THE SYSTEM AND ULTIMATELY ACCELERATES AUTONOMOUS HUMAN LUNAR EXPLORATION.

OBTAIN ACCURACY CONTROL EQUIPMENT TO IMPROVE ACCURACY OF PRE AVAIL COMPARTMENT LEGACY AND COMPARTMENT CLOSEOUT DOCUMENTATION AND REDUCE PRINT AND DESIGN TIMES FOR MAKING CAD MODELS, NASSCO NORFOLK PROPOSES THE PURCHASE OF THE FOLLOWING ACCURACY CONTROL COMPONENTS LEICA GEOSYSTEMS RTC360 LASER SCANNER CREAFORM HANDYSCAN MAX|ELITE CREAFORM HANDYSCAN BLACK|ELITE SECOND-HAND ASSOCIATED SOFTWARE, ACCESSORIES AND TOOLING

SAP PURCHASE REQUISITION: 4200489740

STTR PHASE I: DEVELOPMENT OF AN INTRANASAL VACCINE FOR COVID-19

IMPROVING ACCESS AND AUTOMATING FITTING FOR HEARING AID DEVICES FOR THE UNDERSERVED AND RURAL POPULATIONS - ABSTRACT THIS PROPOSAL RESPONDS DIRECTLY TO THE PURPOSE OF THE RFA-MD-22-003 STTR FUNDING OPPORTUNITY ANNOUNCEMENT (FOA). NEARLY 44 MILLION AMERICANS EXPERIENCE HEARING LOSS, BUT AS MUCH AS 86% OF ADULTS WHO COULD BENEFIT FROM HEARING AID DEVICES (HAD) DO NOT USE THEM. UNTREATED HEARING LOSS IS ALMOST TWICE MORE PREVALENT IN RURAL AREAS. MORE THAN 46 MILLION PEOPLE LIVE IN RURAL AMERICA, BUT THESE COMMUNITIES FACE SIGNIFICANT BARRIERS AND DELAYS IN ACCESSING CARE AND EXPERIENCE A LACK OF PROVIDERS FOR AUDIOLOGY SERVICES. THE AVERAGE RETAIL PRICE OF HADS WAS $4,700, MAKING IT PROHIBITIVELY EXPENSIVE THE RURAL AND MINORITY POPULATIONS WHO HAVE LOWER INCOMES. HEARING LOSS IS ALSO HIGHLY PREVALENT IN BLACK AND LATINO/HISPANIC COMMUNITIES AND GROWING, BUT OLDER BLACK ADULTS WERE 58% AND MEXICAN AMERICAN OLDER ADULTS WERE 78% LESS LIKELY TO USE HADS, DUE TO REASONS OF HIGH COST AND LACK OF INSURANCE COVERAGE. ASIDE FROM COST, CONCERNS ABOUT COMFORT, EFFECTIVENESS AND SATISFACTION ARE THE OTHER SIGNIFICANT BARRIERS TO HAD USAGE. A LONG-TERM GOAL OF HEARING HEALTH PROFESSIONALS, THE AUDITORY RESEARCH COMMUNITY, AND HAD MAKERS HAS BEEN TO REDUCE THESE BARRIERS. THE CURRENT HEARING CARE DELIVERY IN THE U.S. FOLLOWS A MODEL OF SPECIALTY CLINIC- BASED CARE, THROUGH AUDIOLOGISTS, WHICH IS COSTLY AND TIME-CONSUMING FOR THE RURAL AND MINORITY POPULATIONS. THE INTRODUCTION OF OVER-THE-COUNTER (OTC) HADS IS SET TO DISRUPT THIS MODEL AND INCREASE ACCESSIBILITY AND AFFORDABILITY OF HEARING CARE FOR THESE POPULATIONS. AUTOMATION OF HAD FITTINGS AND SELF-ADJUSTMENTS FURTHER ENABLE LISTENERS TO PICK GAIN SETTINGS ACCORDING TO THEIR INDIVIDUAL PREFERENCES, WHICH SIGNIFICANTLY INCREASES LISTENER SATISFACTION AND ACCEPTANCE. IT IS COMMON PRACTICE TODAY FOR AN AUDIOLOGIST TO FOLLOW A TIME-CONSUMING PROCESS IN WHICH SHE FINE TUNES THE HAD SETTINGS TO THE USERS’ INDIVIDUAL DEMANDS, BASED ON VERBAL DESCRIPTIONS FROM THE USER. THIS APPROACH IS BURDENSOME TO BOTH THE AUDIOLOGIST AND THE HAD USER AND MIGHT NOT PROVIDE THE SATISFACTION AND COMFORT THE USER TRULY DESIRES. ALLOWING USERS TO MAKE THESE CHANGES EASILY VIA AUTOMATION CAN VASTLY IMPROVE THEIR SATISFACTION AND USE OF HADS. THIS PROJECT WILL DEVELOP MACHINE LEARNING (ML) BASED AUTOMATIC GAIN ADJUSTMENT SOFTWARE IN A SMARTPHONE WITH A GRAPHICAL USER INTERFACE (GUI), TO MINIMIZE THE EFFORT REQUIRED FOR INDIVIDUALIZED SETTINGS IN AN OTC HAD. RECENT STUDIES OF SELF-ADJUSTED GAIN HAVE SHOWN CONSISTENT WITHIN-SUBJECT PREFERENCES BUT GAIN SETTINGS THAT DIFFER GREATLY FROM PRESCRIBED SETTINGS (UP TO 20DB), AND ALSO SHOWN A GREAT DEAL OF BETWEEN- SUBJECT VARIABILITY IN GAIN PREFERENCES. WE PROPOSE A DEEP NEURAL NETWORK (DNN) BASED PREDICTION MODEL THAT LEARNS THE NON-LINEAR RELATIONSHIPS IN THE DATA AND OUTCOMES, OTHERWISE DIFFICULT TO ASCERTAIN THROUGH NORMAL STATISTICS. THE DNN WILL BE COMBINED WITH OTHER ML TECHNIQUES TO REFINE THE FINAL GAIN SETTINGS. WITH SMARTPHONE ASSISTIVE SOFTWARE AND THE PREDICTIVE POWER OF ML, OUR PROPOSED SOLUTION WILL AUTOMATE PERSONALIZED FITTINGS FOR OTC HADS, SIGNIFICANTLY IMPROVING THEIR ACCESSIBILITY, AFFORDABILITY AND ACCEPTANCE, THUS BENEFITTING THE RURAL AND MINORITY POPULATIONS THE MOST. AUTOMATING HAD GAIN SETTINGS WITH THE USE OF MACHINE LEARNING (ML) TECHNIQUES WILL INCREASE THE EASE OF USE AND REDUCE COSTS WHILE IMPROVING INTELLIGIBILITY AND COMFORT. OTC HADS WILL IMPROVE ACCESS AND COST AND WILL LEAD TO MUCH HIGHER ADOPTIONS OF HADS IN THE RURAL AND MINORITY COMMUNITIES, IMPROVING THEIR QUALITY OF LIFE.

AN AUTOMATED SYSTEM FOR POST-SURGICAL HEALTH AND ENVIRONMENTAL MONITORING WITH REAL-TIME ALERTS FOR LABORATORY RODENTS USING SCALABLE HARDWARE AND DEEP LEARNING - ABSTRACT THIS PROPOSAL RESPONDS DIRECTLY TO THE PAR-21-225 NOVEL TOOLS AND DEVICES FOR ANIMAL RESEARCH FACILITIES AND TO SUPPORT CARE OF ANIMAL MODELS. WHILE IT IS STANDARD PRACTICE TO CONTINUOUSLY MONITOR THE HEALTH OF HUMAN PATIENTS FOLLOWING A MAJOR SURGERY, THIS IS TYPICALLY NOT THE CASE FOR MONITORING RECOVERY IN RODENT PRE- CLINICAL RESEARCH. FOR EXAMPLE, IT IS COMMON PRACTICE THAT RATS AND MICE ARE PROVIDED AN HOUR OF POST-SURGICAL SUPERVISION AND THEN RETURNED TO THEIR HOME CAGE AND COLONY ROOM WITH NO FOLLOW-UP UNTIL THE FOLLOWING DAY. THUS, ANIMALS CAN GO UN-MONITORED FOR MORE THAN 10 TO 12 HOURS FOLLOWING A MAJOR SURGERY. UNMONITORED ANIMALS CAN SUFFER FROM POST-SURGICAL COMPLICATIONS WHICH MAY RESULT IN UNDUE ANIMAL SUFFERING, ADD UNNECESSARY VARIABILITY TO ONGOING EXPERIMENTS, OR REDUCE REPRODUCIBILITY WITHIN AND AMONG RESEARCH GROUPS. STUDIES INVOLVING NEW PROCEDURES, SURGICAL TECHNIQUES OR NEW PERSONNEL HAVE SEEN VERY HIGH MORTALITY RATES (50% - 90%). WHILE THE MONETARY COST OF THE LOSS OF A RAT OR MOUSE IS LOW, THE TIME INVESTED TO TRAIN THE ANIMAL OR TO BUILD THE IMPLANT (E.G., ELECTRODE ARRAY) CAN BE VERY HIGH. WE PROPOSE A WIRELESS AND AUTOMATED IN-CAGE MONITORING AND ALERTING SYSTEM THAT INCORPORATES MULTIPLE ENVIRONMENTAL SENSORS, A THERMAL CAMERA, AND ADVANCED MACHINE LEARNING (ML) SOFTWARE TO IDENTIFY ABERRANT POST-SURGICAL BEHAVIOR (E.G., HUNCHED POSTURE), FLUCTUATIONS IN BODY TEMPERATURE, AND UNFORESEEN ENVIRONMENTAL CONDITIONS (E.G., CHANGES IN WITHIN-CAGE TEMPERATURE, HUMIDITY, LIGHT, AND NOISE) THAT COULD AFFECT ANIMAL WELFARE AND SURVIVAL. BY IDENTIFYING TYPICALLY UNOBSERVED CHANGES IN THE ANIMAL AND THE IN-CAGE ENVIRONMENT, THIS DEVICE COULD IMPROVE REPRODUCIBILITY OF RESEARCH BY ALERTING RESEARCHERS VIA EMAIL OR TEXT NOTIFICATIONS FOLLOWING UNPLANNED VARIATIONS IN CONDITIONS. THE PROPOSED FINAL SYSTEM WILL BE LOW-POWER, WIRELESS AND CAN BE MOUNTED ON ANY STANDARD RODENT HOME CAGE. IT UTILIZES A THERMAL-IMAGING CAMERA COMBINED WITH ML BASED ANOMALY DETECTION TO IDENTIFY CHANGES IN BEHAVIOR (E.G., CHANGES IN MOVEMENT, BODY TEMPERATURE, AND POSTURE) AND ENVIRONMENTAL CONDITIONS. THIS SYSTEM WILL BE DEVELOPED THROUGH CLOSE COLLABORATION WITH VETERINARY PROFESSIONALS AND RESEARCHERS AND THE MACHINE LEARNING MODELS TRAINED ON THERMAL IMAGING VIDEO DATA FROM COHORTS OF RATS AND MICE UNDER VARIOUS CONDITIONS SO THAT IT CAN IDENTIFY BEHAVIORS ASSOCIATED WITH ACUTE PAIN, DISTRESS, AND HEALTH COMPLICATIONS. THIS SYSTEM HAS THE POTENTIAL TO IMPROVE THE WELLBEING AND SURVIVAL OF LABORATORY RODENTS AS WELL AS PROVIDING RESEARCHERS WITH IMPORTANT BEHAVIORAL AND ENVIRONMENTAL DATA THAT CAN BE MONITORED AND STABILIZED TO IMPROVE THE REPRODUCIBILITY OF ONGOING EXPERIMENTS.

FAILURE MODES, EFFECTS AND CRITICALITY ANALYSIS OF HIGH PRESSURE HEAT EXCHANGER SYSTEM

NEPAL TIGER GENOME PROJECT

DETECTING MEDICAL EMERGENCIES IN ISOLATED OLDER ADULTS LIVING ALONE IN RURAL AREAS - ABSTRACT ISOLATED OLDER PERSONS LIVING ALONE IN A RURAL HOUSE ARE AT RISK OF BEING IN MEDICAL DISTRESS WITHOUT HELP. A RURAL HOUSE CAN BE ISOLATED FROM NEIGHBORS WHO CAN EASILY CHECK ON THEIR WELL-BEING. AS THESE PEOPLE BECOME ELDERLY, THEY CAN HAVE A HIGH PREFERENCE TO STAY IN THEIR HOME AS LONG THEY BELIEVE THEY CAN CARE FOR THEMSELVES. AN ELDERLY PERSON ALONE AND IN DISTRESS CAN BE IN A LIFE AND DEATH SITUATION IN AN ISOLATED RURAL HOME. IN AN ISOLATED RURAL HOUSE, MANY DAYS CAN PASS BEFORE SOMEONE DECIDES TO DRIVE TO THEIR LOCATION TO CHECK ON THE ELDERLY PERSON. THIS PROJECT DEVELOPS A LOW-COST MONITORING SOLUTION FOR ISOLATED RURAL ELDERLY TO SAFELY LEAD INDEPENDENT LIVES. THE PHASE I SBIR PROJECT WILL DEVELOP A WIRELESS INDOOR TRACKING SYSTEM TO DETECT A PERSON'S LOCATION THROUGH SEVERAL WALLS OF A TYPICAL RURAL HOUSE. THERE WILL BE NO CABLES TO RUN OR NEED TO INSTALL A COMPLEX ARRAY OF SENSORS THROUGH THE HOUSE. THE COST OF INSTALLATION INEXPENSIVE. THE SYSTEM WILL HAVE BATTERY BACKUP AND PROTOCOLS TO OPERATE OVER LONG POWER OUTAGES. IT WILL ALSO HAVE A CELL PHONE BACKUP COMMUNICATION OPTION SHOULD PHONE LINES BE DOWN. THE SYSTEM WILL IDENTIFY MOTIONS OF THE ELDERLY PERSON 24 HOURS A DAY IN THE HOUSE. MACHINE LEARNING (ML) ALGORITHMS CAN DETECT ABNORMALITIES FROM THEIR DAILY ROUTINE. THE PRODUCT IS INTENDED TO BE AN OPTIONAL ACCESSORY TO IN-HOME ALERT SYSTEMS IN USE TODAY AND WORK WITH MULTIPLE VENDORS OF IN-HOME ALERT SYSTEMS. IT WILL OPERATE IN PARALLEL WITH WEARABLE BUTTONS TO SIGNAL AN ALERT. ONCE THE SYSTEM IDENTIFIES A DISTRESS EVENT HAS OCCURRED IT WILL ACTIVATE THE ALERT SYSTEM THE SAME WAY AS A WEARABLE BUTTON PRESS. THE SAME ALERT PROTOCOL WOULD BE FOLLOWED. IN THESE SYSTEMS AN OPERATOR WOULD FIRST TRY TO TALK TO THE PERSON WITH A SPEAKER PHONE OF THE VENDORS' IN-HOME ALERT SYSTEM. IF THEY CANNOT COMMUNICATE WITH THE PERSON, THEY START WORKING THROUGH A CALL LIST OF LOCAL PEOPLE TO CHECK ON THE HOME. THE PHASE I WILL DEVELOP AND TEST THE WIRELESS INDOOR TRACKING SYSTEM AND THE MACHINE LEARNING (ML) ALGORITHMS.

NEPAL E-DNA PILOT

NEW BIOCASCADE SYSTEM FOR INVESTIGATING THE AIRBORNE TRANSMISSION MODES OF RESPIRATORY VIRUSES - PROJECT SUMMARY WHILE KNOWLEDGE OF THE TRANSMISSION MODES FOR RESPIRATORY PATHOGENIC VIRUSES IS CRITICAL, UNDERSTANDING THEIR TRANSMISSION MECHANISMS IS HAMPERED BY EXISTING SAMPLING METHODS. COMMONLY USED BIOAEROSOL SAMPLERS HAVE LOW COLLECTION EFFICIENCIES FOR PARTICLES < 0.3 M (E.G., INFLUENZA VIRUS AND THE RECENT SARS- COV-2), AND THE PROCESS INVOLVED IN THE COLLECTION OFTEN REDUCES INFECTIVITY, LOWERING THE CHANCES TO ACCURATELY ASSESS THE EXTENT OF THE OCCURRENCE. TO ADDRESS THESE ISSUES, WE DEVELOPED UNDER A NIAID GRANT THE VIABLE VIRUS AEROSOL SAMPLER (VIVAS), WHICH HAS BEEN PROVEN MORE EFFICIENT AND RELIABLE IN COLLECTING VIABLE VIRUSES THAN THE INDUSTRY STANDARD SAMPLERS. THIS SYSTEM HAS BEEN TESTED IN THE LABORATORY AND THE FIELD, AND IT IS NOW COMMERCIALLY AVAILABLE AS THE BIOSPOT SAMPLER (SOLD BY OUR LICENSEE AEROSOL DEVICES INC.). NEVERTHELESS, NONE OF THE COMMERCIAL BIOAEROSOL SAMPLERS, INCLUDING THE BIOSPOT, HAS THE CAPABILITY TO COLLECT SIZE-FRACTIONATED AIRBORNE PARTICLES. ALTHOUGH PREVIOUS EFFORTS HAVE TRIED TO SEPARATE VIRUS-CONTAINING PARTICLES BY AERODYNAMIC SIZE, MAINTAINING THEIR INFECTIVITY DURING SAMPLING REMAINS CHALLENGING. HERE, WE AIM TO DEVELOP A NOVEL SAMPLING SYSTEM, THE BIOCASCADE THAT WILL ALLOW THE COLLECTION INTO LIQUID OF FOUR DIFFERENT PARTICLE FRACTIONS: >10 M, PM4-10, PM1-4 AND PM1 (FINE) WHILE MAINTAINING INFECTIVITY. IN PHASE I, WE WILL BUILD A BIOCASCADE PROTOTYPE THAT CAN BE ATTACHED TO A VIVAS UNIT AND TO A GELATIN FILTER COLLECTION DEVICE. THE PROPOSED APPROACH WILL CREATE A POWERFUL TOOL, NOT AVAILABLE BEFORE, THAT CAN TRANSFORM OUR CURRENT DISEASE- CONTROL PARADIGM FROM A REACTIVE APPROACH (TO AN OUTBREAK AFTER ITS FACT) TO A PROACTIVE APPROACH (INFORMING US THE FORTHCOMING OUTBREAK.) SPECIFIC AIMS OF THIS PROPOSAL ARE: 1) ACHIEVE THE DESIRED PARTICLE SIZE CUT-OFFS (>10 M, PM4-10, PM1-4 AND PM1) WHILE MINIMIZING PARTICLE LOSSES IN THE IMPACTORS AND EFFICIENTLY DELIVERING EACH FRACTION SIMULTANEOUSLY INTO A LIQUID COLLECTION MEDIUM. PRELIMINARY TESTS TO DETERMINE THE EFFECTIVE CUT-OFF OF THE BIOCASCADE WILL BE CONDUCTED AT AEROSOL DYNAMICS INC. IN COMBINATION WITH THE VIABLE VIRUS AEROSOL SAMPLER, USING AEROSOL PARTICLES OF KNOWN SIZES. (2) DEMONSTRATE A HIGH VIABILITY/INFECTIVITY IN THE DELIVERED SAMPLES WHILE ACHIEVING OPTIMAL SIZE SEPARATION. THE BIOCASCADE UNIT COMBINED WITH THE VIVAS OR THE GELATIN FILTER, WILL BE FURTHER TESTED AT THE UNIVERSITY OF FLORIDA USING AEROSOLIZED MICROORGANISMS OF DIFFERENT SIZES. THE EFFECT OF THE SYSTEM ON THE VIABILITY OF THE SAMPLES WILL BE DETERMINED. (3) EVALUATE THE EXPOSURE LEVEL TO INFLUENZA VIRUSES AT A STUDENT HEALTH CARE CENTER (SHCC). THE BIOCASCADE WITH THE VIVAS WILL BE PLACED AT THE WAITING ROOM IN THE SHCC FOR COLLECTING RESPIRATORY VIRUSES IN THE FOUR SIZE FRACTIONS DURING THE “FLU SEASON” TO CAPTURE THE CIRCULATING STRAINS AND TO DETERMINE THE PATHOGEN LOADING IN EACH SIZE FRACTION. THIS INFORMATION WILL BE OF UTMOST IMPORTANCE TO UNDERSTANDING THE REACH OF AN OUTBREAK, ESTABLISHING RECOMMENDATIONS FOR PUBLIC SAFETY, AND DETERMINING THE BEST STRATEGIES TO CONTROL/STOP FUTURE VIRAL DISEASES.

SBIR PHASE I: A FLEXION-BASED COMPUTATIONAL FLUID DYNAMICS TOOL FOR THE FAST COMPUTATION OF TURBULENT FLOW OVER COMPLEX GEOMETRIES

SBIR PHASE I: APPLYING MACHINE LEARNING TO MITIGATE DISRUPTIONS IN NOVEL RELAY TRUCKING MODEL -THE BROADER IMPACTS OF THIS SBIR PHASE I PROJECT INCLUDE A MORE SUSTAINABLE AND PROFITABLE TRUCKING INDUSTRY, ENHANCED CONDITIONS FOR THE TRUCKING WORKFORCE, IMPROVED PUBLIC ROAD SAFETY, REDUCED EMISSIONS, AND A PATH TO FUTURE ADVANCEMENTS USING ALTERNATIVE ENERGY AND AUTONOMOUS TECHNOLOGIES. THIS PROJECT CENTERS ON A PATENTED TECHNOLOGY THAT POOLS SHIPMENTS AND MATCHES TRACTORS AND DRIVERS WITH TRAILERS AND CARGO IN A RELAY FASHION THAT ENSURES EQUIPMENT AND CARGO KEEP MOVING WHILE DRIVERS RETURN HOME DAILY. RESEARCH HAS ESTABLISHED THE THEORETICAL VIABILITY OF APPLYING RELAY MODELS IN LONG-HAUL TRUCKING TO SOLVE EQUIPMENT AND HUMAN CAPACITY ISSUES. USING RELAY TRUCKING COULD POTENTIALLY DOUBLE ASSET UTILIZATION, CUT DELIVERY TIMES IN HALF, AND DECREASE THE HIGH COST OF TRUCK DRIVER TURNOVER. TO DATE, NO COMPANY HAS CREATED A TECHNOLOGY TO IMPLEMENT SCALABLE RELAYS IN AMERICAN TRUCKING. CUSTOMER DISCOVERY AND RESEARCH SUGGESTS THIS IS DUE TO THE COMPLEXITY OF PREDICTING AND MITIGATING REAL-WORLD TRUCKING DISRUPTION EVENTS (E.G. TRAFFIC ACCIDENTS, EQUIPMENT BREAKDOWN ETC.). THE PROJECT AIMS TO ASSESS THE FEASIBILITY OF DEVELOPING A MACHINE LEARNING (ML) BASED PREDICTIVE ANALYTICS TOOL TO MAKE OUR RELAY TECHNOLOGY RESILIENT TO DISRUPTIONS IN THE DRIVER SCHEDULING AND TRUCK ROUTE OPTIMIZATION PROBLEM. A SUCCESSFUL PROJECT WOULD EXTEND A RELAY TRUCKING MODEL BEYOND LARGELY THEORETICAL STUDIES TO BUILD THE FIRST REAL-WORLD APPLICATION IN THE U.S. IT ALIGNS WITH NSF?S MISSION BY TRANSFORMING THE TRUCKING INDUSTRY WHILE CREATING BETTER JOBS FOR NEW AND EXISTING TRUCKERS AND REDUCING CARBON EMISSIONS. WE ESTIMATE THAT RESOLVING THE INEFFICIENCIES RESULTING IN THE LOSS OF $110 BILLION PER YEAR. THIS PROJECT AIMS TO PROVE THE FEASIBILITY OF USING MACHINE LEARNING (ML) TECHNIQUES TO BUILD A PREDICTIVE TOOL THAT INTEGRATES WITH OUR RELAY SCHEDULING ALGORITHMS TO EFFECTIVELY ESTIMATE THE LIKELIHOOD OF OCCURRENCE OF DISRUPTION EVENTS AND PROVIDE ACTIONABLE INTELLIGENCE FOR DEPLOYMENT OF MITIGATION STRATEGIES. A SUCCESSFUL OUTCOME WILL CREATE RESILIENT RELAY ALGORITHMS NECESSARY TO COMMERCIALIZE THE FIRST SCALABLE RELAY TRUCKING OPERATIONS IN THE U.S. WHILE THE USE OF ML HAS BEEN EXPLORED IN PREDICTING WEATHER AND TRAFFIC EVENTS IN THE RECENT PAST, NO OFF-THE-SHELF ML TOOLS ARE KNOWN TO EXIST THAT CAN BE UTILIZED FOR THIS PATENTED RELAY TECHNOLOGY. THIS PROJECT LEVERAGES REAL-WORLD PROPRIETARY OPERATIONAL DATA FROM LARGE TRUCKING COMPANIES, COMBINED WITH PUBLIC DATA SOURCES AND ARTIFICIALLY POPULATED DATASETS REPRESENTING DRIVERS AND EQUIPMENT INFORMED BY WORK WITH LOCAL PARTNERS AT RELAY NODES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

HUMAN CHEMICALLY INDUCED PLURIPOTENT STEM CELLS (CIPSC) GENERATED CARDIOMYOCYTES

THE PURPOSE OF THIS FOLLOW-ON COOPERATIVE AGREEMENT TO NNC13AA01A IS ADVANCING SOFTWAREDEFINED RADIOS (SDR) DEVELOPMENT AND RELATED SPACE COMMUNICATION TECHNOLOGIES WITH RISKREDUCTION ACTIVITIES FOR FUTURE FLIGHT SDR DEVELOPMENT TECHNOLOGY DEMONSTRATIONS ANDCOMMERCIALIZATION. BUILDING UPON PRIOR TECHNOLOGY DEMONSTRATIONS COMPLETED THROUGH THENASA SCAN TESTBED (FORMERLY CONNECT) PROJECT THE COOPERATIVE AGREEMENT WILL CONSIDERPROPER COMMUNICATIONS AND NAVIGATION SYSTEM PHILOSOPHIES TECHNOLOGIES ARCHITECTURALATTRIBUTES MISSION SERVICES AND COMMUNICATIONS CAPABILITIES TO MEET THE NEEDS OF NASA'SNEXT GENERATION ARCHITECTURE FOR SPACE COMMUNICATIONS. THE EFFORT WILL INCLUDE THE STUDY OFSTATE-OF-THE-ART TECHNOLOGIES SUCH AS QUANTUM COMMUNICATIONS AND THE APPLICATION MODELING AND SIMULATION OF THESE TECHNOLOGIES TO MEET THE COST PERFORMANCE MANUFACTURABILITY ANDSECURITY NEEDS OF FUTURE SPACE COMMUNICATION SYSTEMS AND ARCHITECTURES.

WEARABLE DEVICE AND DIGITAL HEALTH PLATFORM TO OPTIMIZE SLEEP DURING PREGNANCY - PROJECT SUMMARY MATERNAL SLEEP HAS SIGNIFICANT INFLUENCE ON MATERNAL HEALTH AND EMERGING IMPACT ON FETAL/NEWBORN HEALTH. SUBOPTIMAL SLEEP AND CLINICAL SLEEP DISORDERS ARE LINKED TO MATERNAL HYPERTENSION, GESTATIONAL DIABETES, FETAL GROWTH PROBLEMS, PRETERM BIRTH, CESAREAN SECTION, STILLBIRTH, AND POSTPARTUM DEPRESSION. THE ABILITY TO TRACK MATERNAL SLEEP AND INTEGRATE METRICS WITH OTHER MARKERS OF WELLBEING, SUCH AS BLOOD PRESSURE, WEIGHT, AND MOOD SCORES ACROSS GESTATION COULD PROVIDE CRITICAL EARLY RISK ASSESSMENTS FOR BOTH PREGNANT INDIVIDUALS AND THEIR HEALTHCARE PROVIDERS. CURRENTLY, NO CONSUMER WEARABLE DEVICE HAS BEEN VALIDATED FOR SLEEP IN PREGNANCY AND NO DEVICE HAS BEEN TESTED FOR INTEGRATION WITH OTHER IMPORTANT HEALTH MEASURES IN THE PREGNANT POPULATION. SMART HUMAN DYNAMICS HAS DEVELOPED A PROTOTYPE DEVICE AND COMPANION APP TO IDENTIFY AND TRACK MATERNAL BODY POSITION DURING SLEEP. IN THIS PROPOSAL, THE PROTOTYPE DEVICE WILL BE AUGMENTED TO ALSO INCLUDE A MICROPHONE TO TRACK SNORING, ALONG WITH OTHER DEVICE-AND-APP FEATURES TO MONITOR BREATHING, BLOOD PRESSURE, WEIGHT GAIN, AND MOOD (IN ADDITION TO EXISTING SLEEP DURATION AND SLEEP POSITION). THE DEVICE WILL BE VALIDATED AGAINST GOLD-STANDARD POLYSOMNOGRAPHY AT THE UNIVERSITY OF MICHIGAN AND WILL BE TESTED IN A USABILITY STUDY WITH PREGNANT INDIVIDUALS. PARTICIPANT FEEDBACK WILL BE OBTAINED TO FURTHER ENHANCE THE DEVICE AND USER EXPERIENCE. THE YIELD WILL BE A VALIDATED MINIATURE SLEEP TRACKER AND COMPANION APP FOR USE IN PREGNANCY. THIS WILL REPRESENT THE FIRST STEP TOWARDS A REAL-TIME SLEEP DIAGNOSTIC TOOL, A SLEEP OPTIMIZER, AND A MOBILE APP, DESIGNED SPECIFICALLY FOR PREGNANT INDIVIDUALS, TO BE DEPLOYED IN PHASE II IN A SYSTEMATIC STUDY TO EVALUATE THE INFLUENCE OF VARIOUS SLEEP BEHAVIORS ON PREGNANCY OUTCOMES. THE OVERALL GOAL IS THAT THIS DEVICE WILL NOT ONLY ENABLE PREGNANT INDIVIDUALS TO SELF-IDENTIFY PREGNANCY HEALTH RISKS, BUT ALSO PROVIDE THE TREATING CLINICIANS ACCESS TO A WEALTH OF HEALTH BEHAVIORS AND PREGNANCY RISK ASSESSMENTS (FOR PREECLAMPSIA, SLEEP-DISORDERED BREATHING, DEPRESSION, AND OTHER CONDITIONS) TO INFORM BETTER DECISION- MAKING.

FIE EARMARK GRANT AWARDS

AWARDED IN RESPONSE TO 2007 INNOVATAIVE PARTNERSHIP PROGRAM (IPP) ENTITLED "CONCEPT STUDY FOR THE APPLICATION OF PHASE DIVERSITY-ONLY ADAPTIVE OPTICS

BUBBLE THERMOGRAPHY VELOCIMETRY FOR URBAN FLOW FIELD CHARACTERIZATION

STTR PHASE I: LOW-COST AUTONOMOUS SAILBOATS FOR LONG-TERM OCEAN MISSIONS -THE BROADER IMPACT/COMMERCIAL POTENTIAL OF THIS SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PHASE I PROJECT IS THE DEVELOPMENT OF NEW TECHNOLOGIES TO FACILITATE OCEAN DATA COLLECTION. UNDERSTANDING THE OCEANS IS IMPORTANT FOR CLIMATE RESEARCH, NAVAL OPERATIONS, MARITIME DOMAIN AWARENESS, AND ECOSYSTEM PRESERVATION, YET TRADITIONAL DATA COLLECTION METHODS USING RESEARCH SHIPS, COMMERCIAL VESSELS, AND BUOYS ARE CUMBERSOME, EXPENSIVE, AND LIMITED IN THEIR SCOPE OF DISCOVERY. WHILE SATELLITES HAVE ENABLED REMOTE DATA COLLECTION, THEY ARE AFFECTED BY WEATHER AND LIMITED IN THE TYPES OF DATA THEY COLLECT. UNCREWED SURFACE VESSELS (USVS) - ROBOTIC BOATS - ARE PROMISING, BUT EVEN TODAY?S SMALLEST OCEANGOING USVS ARE TOO COSTLY FOR MANY APPLICATIONS. THUS, MANY REGIONS OF EARTH?S OCEANS ARE RARELY STUDIED. THE TECHNOLOGY DEVELOPED HERE AIMS TO MEET THIS NEED BY ENABLING LOW-COST DEPLOYMENT OF SENSOR-EQUIPPED ROBOTIC FLEETS. BETTER ACCESS TO OCEAN DATA MAY IMPROVE UNDERSTANDING OF THE OCEAN AND ITS RESOURCES, LEADING TO BETTER CLIMATE MODELING, IMPROVED SAFETY, ECONOMIC GAINS, AND MORE EFFECTIVE REGULATIONS. FURTHER, OCEAN MONITORING AND SURVEILLANCE IS KEY TO UNDERSTANDING OCEAN WATER QUALITY, IDENTIFYING CONTAMINANTS, AND DEVISING STRATEGIES TO PREVENT FUTURE CONTAMINATION AND POLLUTION OF THE OCEAN?S WATERS. ULTIMATELY, COST-EFFECTIVE OCEANIC DATA COLLECTION MAY HELP SUSTAIN AND GROW THE OCEAN ECONOMY. THIS SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PHASE I PROJECT AIMS TO DEVELOP A SMALL, LOW-COST, AUTONOMOUS ROBOTIC SAILBOAT THAT USES AN INNOVATIVE SAIL ARRANGEMENT AND WEATHER-OPTIMIZED NAVIGATION SYSTEM. WITH A COMBINATION OF AFFORDABILITY AND UTILITY, THE TECHNOLOGY REPRESENTS A NEW APPROACH FOR WIDESPREAD OCEANIC DATA COLLECTION. THIS TECHNOLOGY CAN BE DEPLOYED VIRTUALLY ANYWHERE IN THE OCEAN, CAN BE SMALL (2 METERS OR LESS), AND IS 100% WIND- AND SOLAR-POWERED. THE RESEARCH IN THIS PROJECT SEEKS TO FURTHER THIS TECHNOLOGY BY ADVANCING TWO INNOVATIONS: PASSIVE DIRECTIONAL STABILITY AND WEATHER-OPTIMIZED NAVIGATION. UNLIKE MOST OTHER ROBOTIC SAILBOATS, THE PROPOSED USV DOES NOT NEED ACTIVE STEERING TO HOLD A COURSE, ONCE SET. FURTHER, THE PROPOSED USV HAS A NAVIGATION SYSTEM THAT EXPLOITS THE SPATIAL AND TEMPORAL VARIANCE IN THE WEATHER AND USES LOCAL WEATHER DATA TO DIRECT THE BOATS TO NAVIGATE MORE EFFICIENTLY. THIS STTR PROPOSAL SEEKS TO ADDRESS AREAS OF HIGH TECHNICAL RISK INCLUDING STABILITY OF THE STEERING SYSTEM UNDER VARIOUS WIND AND WATER CONDITIONS, RESISTANCE TO TRAVELING EXCESSIVELY DOWNWIND DURING STORMS, EFFECTIVENESS OF THE OPTIMIZED NAVIGATION SYSTEM IN BOTH ACTUAL AND SIMULATED WEATHER CONDITIONS AT LOCATIONS WORLDWIDE, CONSTRUCTION AND PERFORMANCE OF PROTOTYPES IN LAKES AND OCEANS, AND LONG-TERM RESISTANCE TO MARINE ENVIRONMENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

CHEMICALLY INDUCED PLURIPOTENT STEM (CIPS) CELLS ALZHEIMER'S PATIENT SPECIFIC CEL

SBIR PHASE I: HIGH-TEMPERATURE FERMENTATION FOR VOLATILE ORGANIC CHEMICAL PRODUCTION -THE BROADER/COMMERCIAL IMPACT OF THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE I PROJECT ULTIMATELY INCLUDES IMPROVING DOMESTIC CHEMICAL SUPPLY CHAINS BY ENHANCING THE CAPABILITY OF A HYPERTHERMOPHILE ORGANISM TO PRODUCE VOLATILE ORGANIC COMPOUNDS (VOCS), NAMELY ETHANOL AND ACETONE. THE UNITED STATES CONSUMES APPROXIMATELY 14.2 BILLION GALLONS OF ETHANOL AND 0.5 BILLION GALLONS OF ACETONE PER YEAR IN WIDESPREAD USE AS A FUEL ADDITIVE AND INDUSTRIAL SOLVENT, RESPECTIVELY. CURRENTLY, MOST AMERICAN BIOETHANOL IS PRODUCED FROM CORN-DERIVED SUGARS USING A RELATIVELY LOW-TEMPERATURE, YEAST-DEPENDENT BIOPROCESS WHEREAS MOST ACETONE IS PRODUCED FROM FOSSIL FUELS USING THE CUMENE PROCESS. HIGH-TEMPERATURE BIOPROCESS EXHIBITS SEVERAL DISTINCT ADVANTAGES OVER LOW-TEMPERATURE BIOPROCESS, INCLUDING INTRINSIC RESISTANCE TO CONTAMINATION BY OTHER MICROBES AND SIMPLIFIED PRODUCT SEPARATION THROUGH CONTINUOUS VOC DISTILLATION. DESPITE THE PROMISING ATTRIBUTES OF HIGH-TEMPERATURE BIOPROCESS AS A TECHNOLOGY, IMPLEMENTATION HAS NOT BEEN FEASIBLE DUE TO INSUFFICIENT PRODUCT YIELDS. THIS PROJECT AIMS TO USE NOVEL SYNTHETIC BIOLOGY METHODS TO IMPROVE VOC PRODUCTION OF A HYPERTHERMOPHILE. SUCCESS AND IMPLEMENTATION OF THIS PROJECT HAS THE POTENTIAL TO IMPROVE AMERICAN FUEL AND CHEMICAL FEEDSTOCK INDEPENDENCE WHILE INCREASING DEMAND FOR DOMESTIC AGRICULTURAL MARKETS. THE PROPOSED PROJECT SEEKS TO ENGINEER A STRAIN OF HIGH-TEMPERATURE MICROBE TO PRODUCE VOLATILE ORGANIC CHEMICALS, PRIMARILY ETHANOL AND ACETONE, TO INVESTIGATE WHETHER THIS TYPE OF MICROBE COULD FEASIBLY BE USED FOR LARGE-SCALE BIOMANUFACTURING. WHILE MICROBIAL ETHANOL PRODUCTION IS COMMON, IT FACES A VARIETY OF CHALLENGES RELATED TO LOW REACTION RATE, HIGH ENERGY USE, POOR COMPATIBILITY WITH LOWER-COST FEEDSTOCKS, SENSITIVITY TO ENVIRONMENTAL CONTAMINANTS, COMPLICATED PRODUCT SEPARATION, AND INFLEXIBILITY TO PRODUCTS BEYOND ETHANOL. THE SAME IS TRUE OF MICROBIAL ACETONE AND ISOPROPANOL PRODUCTION, WHICH HAVE NOT SEEN INDUSTRIAL USE IN NEARLY A CENTURY. A HIGH-TEMPERATURE SYSTEM CAN ADDRESS THESE CHALLENGES THROUGH FASTER REACTION RATES, LESS HEAT WASTAGE FROM PROCESS COOLING, PASSIVE THERMAL DEGRADATION OF FEEDSTOCKS AND ENVIRONMENTAL CONTAMINANTS, CONTINUOUS PRODUCT DISTILLATION, AND IMPROVED METABOLIC FLEXIBILITY. THIS PROJECT WILL USE METABOLIC ENGINEERING TECHNIQUES TO RE-ROUTE CARBON AND ENERGY FROM THE PRODUCTION OF ORGANIC ACIDS, WHICH ARE INHIBITORY TO GROWTH, LOW-VALUE, AND CHALLENGING TO ISOLATE, AND TOWARDS VOLATILE ORGANIC CHEMICALS LIKE ETHANOL, ACETONE, AND, IF TIME ALLOWS, ISOPROPANOL USING PLANT FIBERS AS A FEEDSTOCK. THIS IS DONE BY UPREGULATION, DOWNREGULATION, AND KNOCKOUT OF NATIVE ENZYMES AND/OR BY HETEROLOGOUSLY EXPRESSING ENZYMES FROM OTHER HIGH-TEMPERATURE MICROBES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

AUTOMATED CONTACT TRACING FOR LARGE BUSINESS USING INDOOR LOCATION TECHNOLOGY

MEASUREMENT OF ATMOSPHERIC SULFURIC ACID CONCENTRATION USING A WATER-BASED CONDENSATION PARTICLE COUNTER

CLINICALLY RELEVANT CIPS CELL LINES

THE OBJECTIVE OF THE PROPOSED WORK IS TO DEVELOP A NEW PROTOTYPE FIELD-WIDENED MICHELSON INTERFEROMETER (FWMI) FOR MEASURING AURORAL INFRARED SPECTRA

OBJECTIVE MULTIMODAL ASSESSMENT OF COGNITIVE AND SENSORIMOTOR FUNCTION AFTER MILD TBI IN STATIC AND DYNAMIC ENVIRONMENTS

SBIR PHASE I: NON-MECHANICAL HARVESTING OF WIND ENERGY

SBIR PHASE I: HIGHLY TAILORED AUTOMATED LAMINATE PRODUCTION FOR ADVANCED COMPOSITE INFUSIONS.

A SIMPLE AND QUANTITATIVE CLINICAL ASSESSMENT OF NEUROMUSCULAR RECOVERY AFTER ACL RECONSTRUCTION

SBIR PHASE I: IMPROVING ACCURACY AND REDUCING SCAN TIME OF DYNAMIC BRAIN PET

STTR PHASE I: INTEGRATION OF PHYSICS-BASED SIMULATION TOOLS TO PROMOTE LEARNING AND INNOVATION IN ENGINEERING

CLL MUTATION DETECTION AND MONITORING FROM BLOOD USING AC ELECTROKINETICS

SMARTPHONE-BASED REWARDS AS A BRIDGE TO TREATMENT FOR NALOXONE REVERSAL PATIENTS

STTR PHASE I DEVELOPMENT OF NOVEL ANTIBACTERIAL AND ANTIFUNGAL BIOADHESIVE BIOMATERIALS FOR DIABETIC SKIN WOUND HEALING

ARTIFICIAL SALIVARY GLAND DENTAL IMPLANT

DEVELOPMENT OF AN ACTIVE SPINAL ORTHOSIS FOR THE TREATMENT OF VERTEBRAL COMPRESSION AND BURST FRACTURES

PORT SECURITY GRANT PROGRAM

HYDRODYNAMIC CHIRALITY: A NOVEL METHOD FOR CHIRAL SEPARATION AND ANALYSIS

HIGH PERFORMANCE COLD SPRAY NOZZLE DESIGN USING COMPRESSED AIR FOR REPAIR OF NUCLEAR COMPONENTS

DEVELOPMENT OF A MODULAR MULTIPHYSICS SIMULATION PLATFORM FOR AEROSOL AND PARTICULATE DISPERSION MODELING

DEVELOPMENT OF HIGH-FIDELITY, MACHINE-LEARNING COMPATIBLE COMPUTATIONAL FLUID DYNAMICS SOFTWARE MODULES BASED ON AMREX

TAS::89 0222::TAS NEW PHASE I 2010 STTR; TITLE: EXTENDING MEASUREMENTS OF ATMOSPHERIC NANO-PARTICLE CHEMISTRY TO 2 NM; PI: SUSANNE HERING

NATURAL REFRIGERANT HIGH PERFORMANCE HEAT PUMP FOR COMMERCIAL APPLICATIONS

RELAY MOBILITY IN LONG-HAUL TRUCKING OPTIMIZING ENERGY EFFICIENCY AND COMMUNITY ENGAGEMENT

STTR PHASE I: NOVEL CONSOLIDATION METHOD FOR NANOSTRUCTURED METALS

NEW SBIR PHASE I 2009: PULSE RESONANCE FOR PHOTOELECTRON ACCELERATION; PI - BROCK ROBERTS

DESIGN SUPPORT METHODOLOGIES AND TOOL-CHAIN FOR HYDROGEN FUEL CELL REGIONAL AND URBAN AIR MOBILITY AIRCRAFT