Jes Corp

HEALTH CENTER CLUSTER

HEALTH CENTER CLUSTER

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

GRANTS WILL BE AWARDED TO ORGANIZATIONS PROPOSING TO ENGAGE AMERICORPS MEMBERS TO STRENGTHEN COMMUNITIES.

OP EARLY INTERVENTION SVCS W/RESPECT TO HIV DISEASE

ALPACA: ADVANCED CRYOGENIC L-BAND PHASED ARRAY CAMERA FOR THE ARECIBO RADIO TELESCOPE

PURPOSE: TO PROVIDE GRANTS TO COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS) FOR THE FOLLOWING PURPOSES 1) TO EXPAND LENDING, GRANT MAKING AND INVESTMENT ACTIVITIES IN LOW OR MODERATE INCOME COMMUNITIES AND TO BORROWERS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC; AND 2) TO ENABLE CDFIS TO BUILD ORGANIZATIONAL CAPACITY AND ACQUIRE TECHNOLOGY, STAFF, AND OTHER TOOLS NECESSARY TO ACCOMPLISH THE ACTIVITIES UNDER A CDFI ERP AWARD. PLANNED ACTIVITIES: ELIGIBLE ACTIVITIES INCLUDE FINANCIAL PRODUCTS, FINANCIAL SERVICES, DEVELOPMENT SERVICES, GRANTS, LOAN LOSS RESERVES AND CAPITAL RESERVES THAT MAY BE USED TO MITIGATE THE IMPACT OF THE COVID 19 PANDEMIC ON UNEMPLOYMENT, CHILDCARE, HEALTHCARE, MENTAL HEALTHCARE, AFFORDABLE HOUSING, AFFORDABLE HOUSING FINANCE, SMALL BUSINESS, SMALL FARMS, BROADBAND INTERNET, AND FOOD SUFFICIENCY. IN ADDITION, TO SUPPORT CDFIS IN BUILDING THEIR CAPACITY TO RESPOND TO THE ECONOMIC IMPACT OF COVID 19, CDFI ERP AWARDS MAY BE USED FOR COMPENSATION PERSONAL SERVICES; COMPENSATION FRINGE BENEFITS; PROFESSIONAL SERVICE COSTS; TRAVEL COSTS; TRAINING AND EDUCATION COSTS; EQUIPMENT; SUPPLIES. END GOALS: EXPANDED FINANCING FOR LOW TO MODERATE INCOME COMMUNITIES AND INDIVIDUALS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC INCLUDING SPECIFIC DESIGNATED COVID IMPACTED CDFI ERP ELIGIBLE GEOGRAPHIES AS AREAS THAT MAY BENEFIT FROM CDFI ERP ASSISTANCE. BENEFICIARIES: CERTIFIED CDFIS WHICH MAY BE FOR PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, AND OTHER PRIVATE INSTITUTION/ORGANIZATION, AS DEFINED IN 12 C.F.R. 1805, AND LOW AND MODERATE INCOME INDIVIDUALS AND FAMILIES. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: SPECIFIC ACTIVITIES RELATING TO BROADBAND USAGE ARE NOT KNOWN AT THE TIME OF AWARD. REASON/PURPOSE OF MODIFICATION: NOT APPLICABLE.

MULTIPLEXED, NON-AMPLIFIED, NUCLEIC ACID-BASED IDENTIFICATION OF MULTIDRUG RESISTANT PATHOGENS USING AN INTEGRATED OPTOFLUIDIC PLATFORM

RESHAPING EDUCATION WITH 21ST CENTURY TECHNOLOGYIN 2006 NASA PROPOSED THREE MAJOR OUTCOMES FOR ITS EDUCATION INITIATIVES:OUTCOME 1: STRENGTHEN THE

STRENGTHENING MECHANISMS FOR THE PROTECTION AND LOCAL INTEGRATION OF VENEZUELANS UNDER FORCIBLY HUMAN MOBILITY SITUATION IN COLOMBIA.

TO CONTRIBUTE TO FULFILLING FUNDAMENTAL RIGHTS, PROTECTION SCENARIOS, AND LOCAL INTEGRATION OF REFUGEE, MIGRANT, ASYLUM-SEEKERS, AND HOST COMMUNITIES IN COLOMBIA.

AMERICORPS NATIONAL

THE JESUIT VOLUNTEER CORPS NORTHWEST (JVCNW) AMERICORPS PROGRAM PROPOSES TO HAVE 142 AMERICORPS MEMBERS WHO WILL BUILD SUSTAINABLE CAPACITY FOR 120 NONPROFIT CONSORTIUM SITES IN 22 REMOTE, RURAL, AND URBAN ECONOMICALLY CHALLENGED COMMUNITIES IN FIVE STATES: ALASKA, IDAHO, MONTANA, OREGON AND WASHINGTON. AT THE END OF THE FIRST PROGRAM YEAR, THE AMERICORPS MEMBERS WILL BE RESPONSIBLE FOR INCREASING THE EFFICIENCY, EFFECTIVENESS, AND/OR PROGRAM SCALE/REACH OF 64 UNDUPLICATED PARTNER SITES THROUGHOUT THE NORTHWEST. IN ADDITION, THE AMERICORPS MEMBERS WILL LEVERAGE AN ESTIMATED 7,000 VOLUNTEERS WHO WILL BE ENGAGED IN INCREASING THE CAPACITY AND OUTREACH OF PARTNER SITES. THE CNCS INVESTMENT OF $1,554,900 WILL BE MATCHED WITH $1,731,355, $334,294 IN PUBLIC FUNDING AND $1,397,061 IN PRIVATE FUNDING.

IN 2008 THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES' NATIONAL COORDINATOR FOR HEALTH INFORMATION TECHNOLOGY RELEASED THE ONC-COORDINATED FEDERA

THIS AWARD FUNDS THE APPROVED 2025-2026 AMERICORPS NATIONAL DIRECT PROGRAM. NO MEMBER MAY ENROLL PRIOR TO THE APPROVED START DATE OF THE MEMBER ENROLLMENT PERIOD. YOUR 2025-2026 REGULATORY MATCH IS 30% AND YOUR BUDGETARY MATCH IS 35.07%.

HIGHER EDUCATION EMERGENCY RELIEF FUND TO COVER ANY COSTS ASSOCIATED WITH SIGNIFICANT CHANGES TO THE DELIVERY OF INSTRUCTION DUE TO THE CORONAVIRUS.

PHYSIOLOGICAL ROLE OF PHOSDUCINS IN THE RETINA

HORIZONS OF FRATERNITY: ACCOMPANYING AND PROTECTING THE MIGRANT POPULATION ON THEIR WAY TO EFFECTIVE INCLUSION IN COLOMBIA

NEW AWARD: TESTING AND MODEL -BASED OPTIMIZATION OF COAL-FIRED PRIMARY HEATER DESIGN FOR INDIRECT SUPERCRITICAL CO2 POWER CYCLES

STRUCTURE AND FUNCTION OF PATHOGENESIS-ASSOCIATED BACTERIAL STRUCTURES BY ELECTRON CRYOTOMOGRAPHY

BRIDGING DIVIDES: A NATIONAL CIVIL DISCOURSE INITIATIVE FOR HIGHER EDUCATION

THIS AWARD FUNDS THE APPROVED 2022?23 AMERICORPS NATIONAL DIRECT PROGRAM. NO MEMBER MAY ENROLL PRIOR TO THE APPROVED START DATE OF THE MEMBER ENROLLMENT PERIOD. YOUR 2022?23 REGULATORY MATCH IS 24% AND YOUR BUDGETARY MATCH IS 50%.

EPIDEMIOLOGY OF ALZHEIMERS DISEASE RESILIENCE AND RISK PEDIGREES

HIGHER EDUCATION EMERGENCY RELIEF FUND TO PROVIDE EMERGENCY FINANCIAL AID GRANTS TO STUDENTS FOR EXPENSES RELATED TO THE DISRUPTION OF CAMPUS OPERATIONS DUE TO CORONAVIRUS.

THIS AWARD IS TO SUPPORT THE JUVENILE JUSTICE AND REHABILITATION PROGRAM UNDER THE CENTRAL AMERICA REGIONAL SECURITY INITIATIVE (CARSI) CHALLENGE GRA

PROTECTION AND SECONDARY EDUCATION FOR SUDANESE REFUGEES AND CHADIANS IN EASTERN CHAD

PROTECTION AND SECONDARY EDUCATION FOR SUDANESE REFUGEES IN EASTERN CHAD

GERIATRICS WORKFORCE ENHANCEMENT PROGRAM

CONGRESSIONALLY DIRECTED SPENDING FOR CONSTRUCTION PROJECTS - THIS IS A NON-COMPETITIVE ANNOUNCEMENT FOR COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING (CPF/CDS) FACILITIES AND/OR EQUIPMENT (“CONSTRUCTION”) PROJECTS THAT WILL BE FUNDED THROUGH THE HEALTH RESOURCES AND SERVICES ADMINISTRATION’S OFFICE OF FEDERAL ASSISTANCE MANAGEMENT (OFAM). THIS DOCUMENT PROVIDES GUIDANCE ON HOW TO SUBMIT AN APPLICATION TO RECEIVE CPF/CDS FUNDING. GENERAL INFORMATION IS PROVIDED ABOUT THE PROJECTS, INCLUDING FUNDING AMOUNTS, LIMITATIONS, ADMINISTRATIVE AND NATIONAL POLICY REQUIREMENTS, AND OTHER IMPORTANT INFORMATION.

UPDATE TECHNOLOGY AT THE CHALLENGER LEARNING CENTER AND SUPPORT SEASONAL EDUCATIONAL PROGRAMMING (CLC-T/E)

TO CONTRIBUTE TO THE PROTECTION AND SOCIAL INTEGRATION OF MIGRANTS, REFUGEES, AND HOST POPULATIONS THROUGH LEGAL ASSISTANCE, PSYCHO-PEDAGOGICAL SUPPORT, IMPROVED ACCESS TO HEALTH SYSTEMS, AND SHELTER.

NATIONAL DIRECT GRANTS ARE AWARDED TO ORGANIZATIONS THAT PROPOSE TO OPERATE AMERICORPS PROGRAMS IN MORE THAN ONE STATE AND APPLY DIRECTLY TO CNCS.

BIOCHEMICAL CONSEQUENCES OF REGIOSPECIFIC METABOLIC BIAS IN THE BRAIN

TO CONTRIBUTE TO THE PROTECTION AND SOCIAL INTEGRATION OF MIGRANTS, REFUGEES, AND HOST POPULATIONS THROUGH LEGAL ASSISTANCE, PSYCHOSOCIAL SUPPORT, IMPROVED ACCESS TO HEALTH SYSTEMS, AND SHELTER.

MINING AND INDUSTRY SAFETY TECHNOLOGY AND TRAINING INNOVATION

STRENGTHENING INSTITUTIONS - HISPANIC SERVING INSTITUTIONS

COMMUNITY RESILIENCE AND SUSTAINABLE LIVELIHOODS FOR CAR REFUGEES AND HOST POPULATION IN CAMEROON (EAST AND ADAMAOUA REGIONS)

ALZHEIMER'S DISEASE IN NATIVE HAWAIIANS AND PACIFIC ISLANDERS: SAMPLE ACQUISITION AND WHOLE GENOME SEQUENCING - PROJECT SUMMARY ALZHEIMER’S DISEASE (AD) IS AMONG THE MOST SIGNIFICANT PUBLIC HEALTH AND MEDICAL CHALLENGES OF OUR DAY. APPROXIMATELY 7 MILLION AMERICANS ARE LIVING WITH AD, AND WITHOUT EFFECTIVE INTERVENTIONS, THE NUMBER WILL DOUBLE IN THE NEXT 25 YEARS. HOMOGENOUS DATASETS LIMIT THE CLINICAL UTILITY OF DISCOVERIES, POSSIBLY LEADING TO RACE-BASED DISPARITIES IN THERAPEUTICS AND DIAGNOSTIC TOOLS. ALMOST ALL AD RESEARCH DATA WERE DERIVED FROM MAJORITY-WHITE POPULATIONS IN HIGH-INCOME COUNTRIES. NATIVE HAWAIIANS AND PACIFIC ISLANDERS (NHPIS) HAVE EXCEPTIONALLY HIGH RISK. YET, DESPITE BEING THE SECOND FASTEST-GROWING RACIAL MINORITY GROUP, NHPIS ARE THE LEAST REPRESENTED RACIAL MINORITY GROUP IN LARGE REPOSITORIES/DATASETS. THE ADSP WAS INITIATED, IN PART, TO SOLVE THE GENETIC ARCHITECTURE OF AD. WHILE LIMITED DATA EXIST, AVAILABLE EVIDENCE SUGGESTS THAT THE GENETIC ARCHITECTURE OF AD IN NHPIS IS UNIQUE. FOR EXAMPLE, THE APOE SNPS ARE NOT CORRELATED WITH AD IN CHAMORROS OR POLYNESIANS. WE PLAN TO DO THE FOLLOWING. AIM 1. RECRUIT AND COLLECT DATA FROM 5,000 NHPIS. WE WILL RECRUIT 1,000 NHPIS ANNUALLY THROUGH OUR NETWORK OF CONNECTIONS, INCLUDING COMMUNITY AND RELIGIOUS LEADERS, SOCIAL MEDIA, RADIO, TV, PERSONAL CONNECTIONS, AND WORD OF MOUTH. EACH PARTICIPANT WILL COMPLETE THOROUGH HEALTH, MEDICAL, SOCIAL DETERMINANTS OF HEALTH, DIET, PHYSICAL ACTIVITY, AND DEMOGRAPHICS SURVEYS; A NEUROPHYSICAL EXAM; PROVIDE A BLOOD SAMPLE; AND AD TESTING. WE WILL COLLECT WHOLE GENOME SEQUENCES, SNP ARRAY DATA, AND STANDARD LABORATORY ASSAYS FOR EACH PARTICIPANT. AIM 2. PARTICIPANT DIAGNOSIS. EACH PARTICIPANT WILL BE DIAGNOSED USING THE NACC BATTERY AND ADJUDICATED FOLLOWING THE PROTOCOLS ESTABLISHED BY ACAD WITH MINOR ADAPTATIONS TO MAKE THE ASSESSMENTS CULTURALLY APPROPRIATE FOR NHPIS. AIM 3. GENETIC ANALYSES. WE WILL DESCRIBE NHPI GENETICS (E.G., ESTIMATE SNP FREQUENCIES IN NHPIS), ANALYZE NHPI POPULATION STRUCTURE, AND CONDUCT THE FIRST AD GWAS IN NHPIS.

DEVELOPING HISPANIC-SERVING INSTITUTIONS PROGRAM

TO IMPROVE THE QUALITY OF LIFE FOR REFUGEES, ASYLUM SEEKERS AND MIGRANTS BY IDENTIFYING AND RESPONDING TO GAPS IN PROTECTION, HEALTH, SHELTER, LIVELIHOODS, AND MENTAL HEALTH AND PSYCHOSOCIAL SUPPORT

"HEALTHEWV"THE PRIMARY GOAL OF HEALTHEWV IS TO MEET THE CONGRESSIONALLY DIRECTED OBJECTIVE TO "EXPAN

PROTECTION AND SECONDARY EDUCATION FOR SUDANESE REFUGEES IN EASTERN CHAD

IMPROVE SAFETY AND ACCESS TO SECONDARY AND LIFE SKILLS EDUCATION TO THE YOUTH OF THE CAMPS AND TO HELP TEACHERS PROVIDE QUALITY TEACHING

IDPS AND RETURNEES IN DUHOK AND NINEWA GOVERNORATES DEVELOP LONG TERM DURABLE SOLUTIONS TO RECOVER FROM THE CONFLICT WITH ISIS IN IRAQ

IDPS AND RETURNEES IN DUHOK AND NINEWA GOVERNORATES DEVELOP LONG-TERM DURABLE SOLUTIONS TO RECOVER FROM THE CONFLICT WITH ISIS IN IRAQ

IMPROVING ACCESS TO INCLUSIVE EDUCATION THROUGH SUSTAINING QUALITY EDUCATION AND STRENGTHENING THE GOVERNANCE SYSTEM BETWEEN STATE SERVICES AND COMMUNITY STRUCTURES

PROTECTION AND SECONDARY EDUCATION FOR SUDANESE REFUGEES IN EASTERN CHAD

IMPROVE QUALITY OF LIFE BY IDENTIFYING AND RESPONDING TO GAPS IN PROTECTION, HEALTH, SHELTER, LIVELIHOODS, AND MENTAL HEALTH AND PSS

WHEELING UNIVERSITY INSTITUTIONAL PORTION OF THE HIGHER EDUCATION EMERGENCY RELIEF FUND UNDER CARES ACT

COMPUTATIONAL AND EXPERIMENTAL INVESTIGATION OF CRYOGENIC GRAIN BOUNDARY MOTION FOR ENHANCED MECHANICAL PROPERTIES

COLOMBIAN REFUGEES AND ASYLUM SEEKERS HAVE IMPROVED RESILIENCE AND INTEGRATION IN ECUADOR THROUGH COMPREHENSIVE ASSISTANCE

COLOMBIAN REFUGEES, ASYLUM SEEKERS AND VENEZUELAN MIGRANTS HAVE IMPROVED RESILIENCE AND INTEGRATION IN ECUADOR THROUGH COMPREHENSIVE ASSISTANCE

NATIONAL TECHNOLOGY TRANSFER CENTER: NASA TECHNOLOGY TRANSFER AND INNOVATION PARTNERSHIP PROGRAM.

IDPS AND RETURNEES IN DOHUK AND NINEWA GOVERNORATES HAVE ENHANCED WELLBEING THROUGH IMPROVED ACCESS TO QUALITY SERVICES

CYBERCORPS SCHOLARSHIP FOR SERVICE: BUILDING RESEARCH-MINDED CYBER LEADERS -THIS PROJECT WILL ESTABLISH A NEW CYBERCORPS? SCHOLARSHIP FOR SERVICE (SFS) PROGRAM AT BRIGHAM YOUNG UNIVERSITY (BYU). OVER THE NEXT FIVE YEARS, THIS PROJECT WILL SUPPORT 23 UNDERGRADUATE AND GRADUATE STUDENTS STUDYING CYBERSECURITY. THESE FUTURE CYBER LEADERS WILL ENTER THE GOVERNMENT WORKFORCE WITH A STRONG GROUNDING IN CYBERSECURITY'S TECHNICAL AND HUMAN DIMENSIONS. SFS UNDERGRADUATE AND GRADUATE STUDENTS WILL HAVE OPPORTUNITIES TO PARTICIPATE IN FACULTY-MENTORED RESEARCH, BYU?S SECURITY OPERATIONS CENTER (SOC), A NEW CYBERCLINIC, CYBERSECURITY AND NETWORKING CLUBS, COMPETITIONS, CAREER FAIRS, GOVERNMENT INTERNSHIPS, AND OUTREACH EFFORTS. IN ADDITION, THIS PROJECT WILL ENABLE STRATEGIC ENHANCEMENTS AT BYU DESIGNED TO INCREASE THE CYBERSECURITY STUDENT DIVERSITY PROFILE, BUILD A STRONG COMMUNITY AMONG SFS STUDENTS, AND PROMOTE STUDENT RESEARCH. THIS WILL, IN TURN, PROVIDE THE GOVERNMENT WITH AN INCREASINGLY DIVERSE SET OF CAPABLE, WELL-CONNECTED GRADUATES READY TO SOLVE THE CYBERSECURITY CHALLENGES OF TODAY AND THE FUTURE. THE BYU SFS PROGRAM IS DESIGNED TO MOTIVATE STUDENTS TO BECOME ETHICAL CYBER LEADERS IN GOVERNMENT, RAISE THE VISIBILITY OF CYBERSECURITY PROGRAMS AND OPPORTUNITIES AT BYU, AND FURTHER DEVELOP PARTNERSHIPS WITH GOVERNMENT AGENCIES. THE PROJECT WILL SUPPORT AN SFS STUDENT RESEARCH SYMPOSIUM, A GOVERNMENT CYBERSECURITY CAREER EVENT TIED TO BYU?S STEM FAIR, AND NEW DIVERSITY OUTREACH EFFORTS THAT WILL BETTER INTEGRATE EFFORTS ACROSS CAMPUS (E.G., BYU ENGINEERING BE TOGETHER, WOMEN IN CYBERSECURITY CLUB, CS BELONGING, WOMEN IN COMPUTER SCIENCE, BYU MULTICULTURAL STUDENT SERVICES) AND THE COMMUNITY TO RECRUIT MORE WOMEN, MINORITIES, AND FIRST-GENERATION STUDENTS INTO THE FIELD. A NEW CYBERSECURITY SFS SEMINAR WILL HELP BUILD A COMMUNITY AMONG SFS STUDENTS AND FACULTY AND BRING IN EXPERTS FROM OTHER UNIVERSITIES AND GOVERNMENT AGENCIES. STUDENTS PARTICIPATING IN RESEARCH WILL WORK WITH FACULTY STUDYING HIGH-PRIORITY AREAS, INCLUDING AI AND CYBERSECURITY, HUMAN ASPECTS OF CYBERSECURITY, EMBEDDED SYSTEMS SECURITY, NETWORK SECURITY, AND CYBERSECURITY EDUCATION. GRADUATE SFS STUDENTS WILL COMPLETE A RIGOROUS THESIS CENTERED AROUND A CYBERSECURITY TOPIC, HELPING PREPARE THEM FOR CUTTING-EDGE RESEARCH WITHIN GOVERNMENT INSTITUTIONS. THIS PROJECT IS SUPPORTED BY THE CYBERCORPS? SCHOLARSHIP FOR SERVICE (SFS) PROGRAM, WHICH FUNDS PROPOSALS ESTABLISHING OR CONTINUING SCHOLARSHIP PROGRAMS IN CYBERSECURITY AND ALIGNS WITH THE U.S. NATIONAL CYBER STRATEGY TO DEVELOP A SUPERIOR CYBERSECURITY WORKFORCE. FOLLOWING GRADUATION, SCHOLARSHIP RECIPIENTS ARE REQUIRED TO WORK IN CYBERSECURITY FOR A FEDERAL, STATE, LOCAL, OR TRIBAL GOVERNMENT ORGANIZATION FOR THE SAME DURATION AS THEIR SCHOLARSHIP SUPPORT. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

I/UCRC: CENTER FOR UNMANNED AIRCRAFT SYSTEMS, PHASE II SITE

PROTECTION AND HEALTH SERVICES FOR CAMEROONIAN REFUGEES IN TARABA STATE

ROSEMONT COLLEGE INSTITUTIONAL EMERGENCY RELIEF PROJECT RESULTING FROM EFFECTS OF CORONAVIRUS PANDEMIC

PHASE II: NASA TECHNOLOGY TRANSFER AND INNOVATIVE PARTNERSHIP PROGRAMTHE NATIONAL TECHNOLOGY TRANSFE

NICOTINE AND ALCOHOL CO-DEPENDENCE

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

RUI: CYGAMES: CYBER-ENABLED TEACHING AND LEARNING THROUGH GAME-BASED, METAPHOR ENHANCED LEARNING OBJECTS

BUILD CAPACITY OF SUDANESE REFUGEES SO AS TO MAINTAIN AND OPERATE THEIR OWN SCHOOL SYSTEM

ACCESS TO QUALITY EDUCATION, PROTECTION AND PSYCHOSOCIAL SUPPORT FOR REFUGEES AND HOST COMMUNITY IN MABAN

HOLISTIC PROTECTION AND ACCOMPANIMENT FOR REFUGEES AND HOST COMMUNITY IN MABAN.

THE REFUGEES AND HOST COMMUNITY IN MABAN, UPPER NILE STATE HAVE ACCESS TO QUALITY EDUCATION, PROTECTION AND PSYCHOSOCIAL SUPPORT.

NATIVE AMERICAN-SERVING NONTRIBAL INSTITUTIONS PROGRAM

HEALTH CENTER CORONAVIRUS AID, RELIEF, AND ECONOMIC SECURITY (CARES) ACT FUNDING

REFUGEE AND HOST COMMUNITIES IN MABAN ARE EMPOWERED AND RESILIENT

REFUGEE AND HOST COMMUNITIES IN MABAN ARE EMPOWERED AND RESILIENT.

INCREASING ACCESS TO PROTECTION, MENTAL HEALTH, PSYCHOSOCIAL SUPPORT, AND EDUCATION FOR IDP AND RETURNEE MINORITIES IN DOHUK AND NINEWA GOVERNORATES

PROTECTION AND HEALTH SERVICES FOR CAMEROONIAN REFUGEES IN TARABA STATE

LEGAL SUPPORT, PROTECTION, SAFE TEMPORARY SHELTER, PSYCHOSOCIAL SUPPORT, HEALTH CARE, LOCAL CAPACITY BUILDING AND AWARENESS RAISING

IRON BASED COUPLING MEDIA (IBCM) FOR MRI-GUIDED TRANSCRANIAL ULTRASOUND SURGERIES - PROJECT SUMMARY/ABSTRACT FATAL OR IMPAIRING NEUROLOGICAL DISEASES, INCLUDING MOVEMENT DISORDERS, BRAIN CANCERS, PSYCHOLOGICAL DISORDERS, EPILEPSIES, MALFORMATIONS, AND MEMORY DISORDERS, IMPOSE HEAVY BURDENS ON BOTH INDIVIDUALS AND SOCIETY AT LARGE. TRANSCRANIAL MAGNETIC RESONANCE GUIDED FOCUSED ULTRASOUND SURGERY (TMRGFUS) IS AN EXTREMELY PROMISING, MINIMALLY INVASIVE TREATMENT MODALITY FOR NEUROLOGICAL DISEASES WHEREBY SOUND WAVES ARE FOCUSED TO A SPECIFIC REGION OF THE BRAIN. BECAUSE IT IS NONINVASIVE, THE EFFICACY OF TMRGFUS PROCEDURE HEAVILY RELIES ON THE ACCURACY AND INFORMATION CONTENT OF THE GUIDANCE TECHNOLOGY. THIS STUDY PROPOSES TO IMPROVE THE TREATMENT EFFICACY OF NEARLY ALL TMRGFUS SURGERIES BY ELIMINATING A UBIQUITOUS IMPEDIMENT TO ACCURATE AND INFORMATION-RICH GUIDANCE MRI: THE ACOUSTIC COUPLING MEDIUM. INTERACTIONS BETWEEN THE COUPLING MEDIA AND GUIDANCE IMAGING IMPEDE TMRGFUS EFFICACY AND TRANSLATION. FOR EXAMPLE, WHILE FDA-APPROVED TMRGFUS TREATMENTS FOR ESSENTIAL TREMOR AND PARKINSON’S DISEASE CAN RELY ON REAL-TIME PATIENT FEEDBACK TO COMPENSATE FOR ERRORS IN GUIDANCE MR IMAGING, OTHER TMRGFUS INDICATIONS CANNOT ACCESS PATIENT FEEDBACK BECAUSE EITHER THE PATIENT IS UNCONSCIOUS, OR THE CONSEQUENCES OF TREATMENT ERRORS APPEAR ONLY DAYS LATER. IN THESE CASES, GUIDANCE IMAGING ERRORS IMPOSED BY THE COUPLING BATH CANNOT BE COMPENSATED AND DEGRADE TREATMENT EFFICACY TO MEET THIS NEED, OUR STUDY PROPOSES A DILUTE, IRON-BASED COUPLING MEDIA (IBCM) THAT WILL ELIMINATE COUPLING- MEDIA-INDUCED ERRORS IN MRI GUIDANCE IMAGING WHILE MAINTAINING THE COUPLING AND COOLING FUNCTIONALITY CRITICAL TO ACOUSTIC TRANSMISSION. THE SPECIFIC AIMS OF THE STUDY ARE AS FOLLOWS. AIM 1: DEVELOP NOVEL SURFACE–MODIFIED IRON OXIDE NANOPARTICLES FOR AN IBCM. DILUTE, AQUEOUS, SURFACE- MODIFIED IRON OXIDE NANOPARTICLES CAN ACCELERATE MRI SIGNAL DECAY SUCH THAT, DURING IMAGE ACQUISITION, A COUPLING MEDIUM WILL CONTRIBUTE NEGLIGIBLE EFFECTS TO GUIDANCE IMAGING. HOWEVER, AQUEOUS NANOPARTICLES ALSO AGGLOMERATE AND SEED TREATMENT-IMPEDING CAVITATION NUCLEATION IN THE PREFOCAL ACOUSTIC FIELD. THIS AIM WILL DEVELOP NOVEL SURFACE-MODIFIED PARTICLES THAT, UPON SUSPENSION, ACCELERATE MRI SIGNAL DECAY WITHOUT PROMOTING PREFOCAL NUCLEATION. AIM 2: INVESTIGATE THE EFFECTS OF IBCM SUSPENSION FLUID PROPERTIES ON CAVITATION NUCLEATION. FLUID PROPERTIES PLAY A CRITICAL ROLE IN PARTICLE SUSPENSION, ACOUSTIC COUPLING, SUBJECT COOLING, AND CAVITATION NUCLEATION. THIS AIM WILL INVESTIGATE CAVITATION NUCLEATION WITHIN THE IBCM AND HOW SUSPENSION FLUID PROPERTIES, SUCH AS PH, TEMPERATURE, GAS CONTENT, AND FLOW STATE, CAN MODIFY OR SUPPRESS THE NUCLEATION PROCESS WHILE MAINTAINING SUSPENSION, COUPLING, AND COOLING CAPABILITIES. AIM 3: ENHANCE MRI GUIDANCE FOR TMRGFUS THROUGH THE USE OF AN IBCM. THIS AIM WILL QUANTIFY THE VALUE OF THE IBCM DESIGNED IN AIMS 1 AND 2 FOR TMRGFUS BY MEASURING IMAGE QUALITY METRICS DERIVED FROM GUIDANCE MRI SCANS OF HUMAN SUBJECTS. THIS AIM WILL ALSO DEVELOP NOVEL MRI GUIDANCE TECHNIQUES THAT WERE PREVIOUSLY RENDERED IMPOSSIBLE DUE TO SEVERE IMAGE CORRUPTIONS IMPOSED BY THE ACOUSTIC COUPLING MEDIUM. THE RESULTING IBCM WILL IMPROVE IMAGE QUALITY FOR NEARLY ALL GUIDANCE TECHNIQUES EMPLOYED DURING, OR UNDERGOING DEVELOPMENT FOR, TMRGFUS, BY RENDERING THE ACOUSTIC COUPLING MEDIUM INVISIBLE TO THE MRI SCANNER WITHOUT SACRIFICING NECESSARY ACOUSTIC COUPLING AND COOLING FUNCTIONALITY.

WHEELING UNIVERSITY EMERGENCY FINANCIAL AID GRANTS TO STUDENTS UNDER THE CORONAVIRUS AID, RELIEF, AND ECONOMIC SECURITY (CARES) ACT

TO PROMOTE ACCESS TO RIGHTS AND IMPROVEMENT IN THE LIVING CONDITIONS OF THE VENEZUELAN POPULATION IN SITUATION OF FORCED MIGRATION.

CDFI RAPID RESPONSE PROGRAM AWARD

DEMONSTRATION OF THE DRY FERMENTATION OF FOOD AND YARD WASTE INTO BIOGAS AND BIOPRODUCTS FOR LARGE-SCALE INDUSTRIAL APPLICATIONS

OPTIMIZING VIRTUAL CARE

PROMOTION OF PROTECTION, MENTAL HEALTH, AND ACCESS TO LIVELIHOODS FOR REFUGEES, MIGRANTS, AND HOST COMMUNITY FOR INTEGRATION AND PEACEFUL COEXISTANCE

NASA SPONSORED CLASSROOM OF THE FUTURE

TO PROMOTE PROTECTION, MENTAL HEALTH, AND ACCESS TO LIVELIHOODS FOR REFUGEES, VENEZUELAN REFUGEES, AND HOST COMMUNITY, FOR THEIR LOCAL INTEGRATION AND PEACEFUL COEXISTENCE IN PERU

ENHANCED SENSITIVITY AND QUANTITATIVE PRECISION FOR SINGLE CELL PROTEOMICS - SINGLE CELL PROTEOMICS (SCP) IS RAPIDLY EMERGING AND CAN QUANTIFY > 1000 PROTEINS PER CELL. SIGNIFICANT ADVANCES IN INSTRUMENTATION AND SAMPLE PREPARATION ARE MAKING SCP MORE BROADLY ACCESSIBLE. YET TECHNICAL ADVANCES IN DATA ACQUISITION HAVE NOT BEEN PAIRED WITH ADVANCES TO COMPUTATIONAL TOOLS. ALGORITHMS FOR PROTEOMICS WERE DESIGNED AND OPTIMIZED ON DATA FROM BULK PROTEOMICS, AND ARE ILL-SUITED FOR SCP DATA. OUR PRELIMINARY RESEARCH SHOWS THAT DATA FROM SCP LACK MANY FEATURES THAT ARE CRITICAL FOR CURRENT PROTEOMICS ALGORITHMS. WE WILL DRAMATICALLY IMPROVE ACCURACY AND COVERAGE OF THE SINGLE CELL PROTEOME THROUGH CREATION OF THE FIRST-EVER DEDICATED SCP SEARCH SOFTWARE. THIS WILL BE COUPLED WITH AN INITIATIVE TO IMPROVE SCP PEPTIDE AND PROTEIN QUANTIFICATION. THESE ALGORITHMIC IMPROVEMENTS WILL BE INFORMED FROM A LARGE CORPUS OF SCP DATA, GATHERED AND CENTRALIZED INTO THE FIRST SCP DATA ARCHIVE.

SEC. 5 HIGHER BLENDS INFRASTRUCTURE INCENTIVE PROGRAM GRANT - IRA

ROSEMONT COLLEGE EMERGENCY STUDENT RELIEF PROGRAM

ASSESSING THE INFLUENCE OF SPACE LAUNCH AND LANDING NOISE ON SPECIES OF CONCERN AT VANDENBERG SPACE FORCE BASE.

ADVANCED SAMPLE PREPARATION, SEPARATION AND MULTIPLEXED ANALYSIS FOR IN-DEPTH PROTEOME PROFILING OF >1000 SINGLE CELLS PER DAY - PROJECT SUMMARY/ABSTRACT CANCER TISSUES EXHIBIT A HIGH DEGREE OF PHENOTYPIC HETEROGENEITY AND PLASTICITY AND CONTAIN NUMEROUS SUBPOPULATIONS OF CELLS IN VARIOUS STATES. QUANTIFYING THIS HETEROGENEITY AT THE SINGLE-CELL LEVEL AND WITH MOLECULAR DEPTH ACROSS LARGE NUMBERS OF CELLS PROVIDES INFORMATION THAT CANNOT BE OBTAINED AT THE BULK SCALE AND WILL ULTIMATELY LEAD TO IMPROVED DIAGNOSTICS AND MORE EFFECTIVE TREATMENTS. WHILE SINGLE-CELL NUCLEIC ACID SEQUENCING APPROACHES ARE HAVING A SIGNIFICANT IMPACT ON CANCER RESEARCH, PROTEINS MEDIATE THE BULK OF CELLULAR FUNCTION AND ARE THE TARGETS OF MOST THERAPEUTICS. THERE IS THUS AN URGENT NEED TO DEVELOP NEW TECHNOLOGIES FOR LARGE- SCALE DIRECT PROTEOME PROFILING AT THE SINGLE-CELL LEVEL. TO FILL THIS GAP, MASS SPECTROMETRY (MS)-BASED PROFILING OF PROTEIN EXPRESSION IN SINGLE CELLS HAS RECENTLY BEEN DEMONSTRATED THROUGH THE IMPLEMENTATION OF MORE EFFICIENT SAMPLE PROCESSING WORKFLOWS, NOVEL EXPERIMENTAL DESIGNS AND IMPROVED INSTRUMENT SENSITIVITY. LABEL-FREE MS- BASED PROTEOMICS CAN NOW QUANTIFY >2,000 PROTEIN GROUPS PER CELL ACROSS >4 ORDERS OF MAGNITUDE OF DYNAMIC RANGE, BUT EFFORTS TO PROFILE MORE THAN A FEW DOZEN CELLS PER DAY HAVE RESULTED IN SIGNIFICANTLY REDUCED PROTEOME COVERAGE. THIS LOW THROUGHPUT IS INSUFFICIENT FOR THE LARGE-SCALE STATISTICALLY POWERED STUDIES REQUIRED TO CHARACTERIZE HETEROGENEITY IN CANCER CELL POPULATIONS. TO INCREASE MEASUREMENT THROUGHPUT, MULTIPLEXED WORKFLOWS BASED ON ISOBARIC TANDEM MASS TAGS (TMTS) ENABLE UP TO 18 SINGLE CELLS TO BE MEASURED IN AN LC- MS ANALYSIS, BUT THESE HAVE STILL BEEN LIMITED TO ~100 CELLS/DAY AND, AS GENERALLY IMPLEMENTED, SUFFER FROM A LARGE PROPORTION OF MISSING VALUES AND OTHER ISSUES AFFECTING QUANTITATIVE PERFORMANCE. OUR OVERALL OBJECTIVE IS TO DEVELOP A PLATFORM THAT COMBINES SIMPLIFIED PIPETTE-FREE HIGH-THROUGHPUT SAMPLE PREPARATION WITH RAPID, MULTICOLUMN LIQUID CHROMATOGRAPHY SEPARATIONS AND ‘GREEDY’ DATA-DEPENDENT ACQUISITION TO PROFILE >2000 PROTEINS PER CELL WITH A MEASUREMENT THROUGHPUT OF >1000 SINGLE CELLS PER DAY. WE HYPOTHESIZE THAT THE ADVANCED SAMPLE PREPARATION AND SEPARATION, COMBINED WITH A FAR MORE EFFICIENT MS ACQUISITION WORKFLOW, WILL ACHIEVE IN-DEPTH SCP WITH A 10× THROUGHPUT GAIN, THUS PROVIDING A CAPABILITY FOR DIRECT, IN-DEPTH AND LARGE-SCALE PROTEIN QUANTIFICATION THAT IS ANALOGOUS TO SINGLE-CELL RNA-SEQ. STUDIES IN AIM 1 WILL FOCUS ON DEVELOPING MASSIVELY PARALLEL CENTRIFUGAL NANOLITER DISPENSING TO PREPARE >10,000 SINGLE-CELLS PER DAY AT A TOTAL REAGENT AND CONSUMABLES COST OF <$0.40/CELL. IN AIM 2, WE WILL DEVELOP RAPID, ROBUST AND HIGH-PEAK-CAPACITY 20-MIN NANOLC SEPARATIONS WITH 100% DUTY CYCLE. IN AIM 3, WE WILL DEVELOP A NOVEL ‘GREEDY’ DATA ACQUISITION STRATEGY IN WHICH ONLY PROTEOTYPIC PEPTIDES ARE SELECTED FOR FRAGMENTATION, AND WITH CUSTOM AUTOMATIC GAIN CONTROL SETTINGS AND FRAGMENTATION ENERGY FOR EACH PEPTIDE, PROVIDING AN UNPRECEDENTED COMBINATION OF SENSITIVITY AND THROUGHPUT. WITH THIS NEXT-GENERATION PLATFORM, WE WILL PROFILE >10,000 CELLS TO STUDY ACQUIRED RESISTANCE TO AUTOPHAGY INHIBITORS IN THE CONTEXT OF AUTOPHAGY-DEPENDENT TRIPLE NEGATIVE BREAST CANCER, THUS ESTABLISHING AN INNOVATIVE PLATFORM FOR ADVANCING BIOMEDICAL RESEARCH AND INDIVIDUALIZING THERAPY.

FULLY AUTOMATED AND ULTRA-HIGH-THROUGHPUT PLATFORM FOR IN-DEPTH SINGLE-CELL PROTEOMICS

SQ3C - STUDENT QUALITY IN CULTURE, COMPREHENSION AND COMPLETION

LIVELIHOOD AND PSYCHOSOCIAL SUPPORT FOR URBAN REFUGEES IN KAMPALA. INCREASED RESILIENCE OF URBAN REFUGEES AND VULNERABLE HOST COMMUNITY MEMBERS THROUGH LIVELIHOODS TRAINING, SOCIO-ECONOMIC INTEGRATION, AND PSYCHOSOCIAL SUPPORT.

IMPROVED RESILIENCE AND INTEGRATION THROUGH URGENT BASIC NEEDS, SHELTER, PROTECTION, SGBV PREVENTION, MENTAL HEALTH AND PSYCHOSOCIAL SUPPORT.

REFUGEES AND HOST COMMUNITY IN MABAN COUNTIES- NORTHERN UPPER NILE STATE HAVE ACCESS TO QUALITY EDUCATION. PROTECTION AND PSYCHOSOCIAL SUPPORT

LIVELIHOOD AND PSYCHOSOCIAL SUPPORT FOR URBAN REFUGEES IN KAMPALA

ARRA - CAPITAL IMPROVEMENT PROGRAM

DEVELOPING THE PEDAGOGICAL SKILLS AND SCIENCE EXPERTISE OF TEACHERS IN UNDERSERVED RURAL SETTINGS

ACCESS TO PERSONAL AND SOCIO-ECONOMIC DEVELOPMENT FOR ALL AGES TO INCREASE SOCIAL INTEGRATION OF MARGINALIZED REFUGEES

ACCESS TO ECONOMIC AND SOCIAL INTEGRATION FOR CAR REFUGEES AND THE LOCAL COMMUNITY IN LA KADEY AND LOM ET DJEREM DEPARTMENTS

AREA A: IN-DEPTH PROTEOME MAPPING OF THE TUMOR MICROENVIRONMENT WITH SINGLE-CELL RESOLUTION

INCREASING THE ECONOMIC AND SOCIAL INTEGRATION OF MARGINALIZED REFUGEE AND HOST COMMUNITY GROUPS IN LA KADEY AND LOM ET DJEREM DEPARTMENTS

REFUGEES AND HOST COMMUNITY IN MABAN COUNTIES NORTHERN UPPER NILE HAVE ACCESS TO QUALITY EDUCATION. PROTECTION AND PSYCHOSOCIAL SUPPORT

COMMUNITY RESILIENCE AND SUSTAINABLE LIVELIHOODS FOR CAR REFUGEES AND HOST POPULATION IN CAMEROON (EAST AND ADAMAOUA REGIONS)

BULKY DEHYDROAMINO ACIDS AS CONSTRAINING AND STABILIZING COMPONENTS OF PEPTIDES

COLLABORATIVE RESEARCH: DESIGNING A TEACHER LEARNING SEQUENCE FOR BUILDING ON MATHEMATICAL OPPORTUNITIES IN STUDENT THINKING -MATHEMATICAL OPPORTUNITIES IN STUDENT THINKING (MOSTS) ARE HIGH-LEVERAGE INSTANCES OF STUDENT MATHEMATICAL THINKING THAT EMERGE IN WHOLE-CLASS DISCUSSIONS. THE CHALLENGE FOR TEACHERS IS TO BUILD ON THESE OPPORTUNITIES TO HELP THE WHOLE CLASS UNDERSTAND THE MATHEMATICS UNDERLYING THESE STUDENT CONTRIBUTIONS. TO HELP TEACHERS LEARN HOW TO BUILD ON MOSTS, THERE IS A NEED FOR PROFESSIONAL DEVELOPMENT RESOURCES AND TOOLS THAT FACILITATORS CAN USE. THERE IS ALSO A NEED FOR RESEARCH ABOUT HOW TEACHERS USE WHAT THEY LEARN IN PROFESSIONAL DEVELOPMENT IN THEIR TEACHING. THIS PROJECT IS DEVELOPING A TEACHER LEARNING SEQUENCE THAT WILL SUPPORT TEACHERS IN LEARNING TO PRODUCTIVELY USE STUDENT THINKING THAT SURFACES IN-THE-MOMENT DURING THEIR INSTRUCTION?THAT IS, IN LEARNING TO BUILD ON MOSTS. THIS PROJECT BUILDS ON PRIOR WORK THAT DEVELOPED A FRAMEWORK FOR RECOGNIZING MOSTS AND CONCEPTUALIZED THE BUILDING PRACTICE TEACHERS USE TO EFFECTIVELY CAPITALIZE ON MOSTS. THE OVERARCHING RESEARCH QUESTION FOR THE PROJECT IS: TO WHAT EXTENT DOES THE PROFESSIONAL LEARNING SEQUENCE HELP TEACHERS UNDERSTAND AND ENACT THE TEACHING PRACTICE OF BUILDING? AS PART OF THIS INVESTIGATION, THE PROJECT ALSO CONSIDERS FACTORS THAT MIGHT MITIGATE TEACHERS? LEARNING, SUCH AS TEACHER ATTRIBUTES (KNOWLEDGE, PRACTICES, OR EXPERIENCES) AND CONTEXTUAL FACTORS. THE STUDY USES A DESIGN RESEARCH FRAMEWORK TO DOCUMENT HOW TEACHERS TAKE UP ASPECTS OF BUILDING ON MOSTS FROM THE PROFESSIONAL DEVELOPMENT, THE PROCESS OF TEACHERS? LEARNING, AND CHANGES IN THEIR CLASSROOM PRACTICE. THE STUDY RELIES ON DATA FROM THE PROFESSIONAL DEVELOPMENT ACTIVITIES, TEACHER SURVEYS AND INTERVIEWS, AND CLASSROOM DATA. THE PROJECT SITES INCLUDE SECONDARY SCHOOLS IN URBAN AND RURAL SETTINGS. THE DISCOVERY RESEARCH PREK-12 PROGRAM (DRK-12) IS AN APPLIED RESEARCH PROGRAM THAT SEEKS TO SIGNIFICANTLY ENHANCE THE LEARNING AND TEACHING OF SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) BY PREK-12 STUDENTS AND TEACHERS. PROJECTS IN THE DRK-12 PROGRAM BUILD ON FUNDAMENTAL RESEARCH IN STEM EDUCATION AND PRIOR RESEARCH AND DEVELOPMENT EFFORTS THAT PROVIDE THEORETICAL AND EMPIRICAL JUSTIFICATION FOR FUNDED PROJECTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

CONTINUUM OF CARE PROGRAM

NATURAL DISASTERS & HEALTHNDH WILL INSPIRE AND INFORM MIDDLE SCHOOL STUDENTS ABOUT LIFE-THREATENING HEALTH EFFECTS OF NATURAL DISASTERS. STUDENTS ROLE-PLAY SCIENTISTS IN 90-MIN LIVE SIMULATIONS.

LIVELIHOOD ANDPSYCHOSOCIAL SUPPORT FOR URBAN REFUGEES IN KAMPALA

MOLECULAR MECHANISMS OF YEAST PAS KINASE REGULATION AND FUNCTION.

NEUROIMMUNE MECHANISMS OF ALCOHOL REWARD - PROJECT SUMMARY/ABSTRACT THE PREVAILING DOGMA IN THE ALCOHOL FIELD IS THAT THE REWARDING PROPERTIES OF ETHANOL (ETOH) RESULT FROM ENHANCEMENT OF VENTRAL TEGMENTAL AREA (VTA) DOPAMINE (DA) NEURAL ACTIVITY AND ACCOMPANYING DA RELEASE IN THE MESOLIMBIC REWARD SYSTEM. IN PRELIMINARY STUDIES, WE WILL DEMONSTRATE THAT SOME OF ETOH’S EFFECTS ON MIDBRAIN NEURONS AND NAC DA RELEASE ARE MEDIATED BY PERIPHERAL SUBSTRATES INCLUDING DA D2-SUBTYPE 2 RECEPTOR (D2R) EXPRESSING MONOCYTE-DERIVED MACROPHAGES (MDMS). THESE FINDINGS SUGGEST A NEUROIMMUNE INTERACTION FOR ACUTE ETOH USE AND CHALLENGE THE DOGMA THAT ETOH HAS EXCLUSIVELY CENTRAL EFFECTS ON DA NEURONAL ACTIVITY, RELEASE, AND REWARD. OUR PROPOSED STUDIES CONSTITUTE A FOCUSED INVESTIGATION INTO THE ROLE OF NEUROIMMUNE INTERACTIONS IN ETOH EFFECTS ON VTA NEURONS, DA TRANSMISSION, AND ETOH REWARD AND CONSUMPTION. THE CORE THESIS IS THAT ACUTE ETOH ENHANCEMENT OF MESOLIMBIC DA TRANSMISSION AND ETOH REWARD IS MEDIATED BY ETOH ENHANCEMENT OF BLOOD DA, SUBSEQUENT ACTIVATION OF D2R-EXPRESSING MDMS, AND SUBSEQUENT CYTOKINE MODULATION OF VTA NEURONS, THAT ARE RESPONSIBLE FOR CHRONIC ADAPTATIONS IN VTA GABA NEURONS AND DA RELEASE. PRIOR AND PRELIMINARY EVIDENCE SUPPORTING OUR HYPOTHESIS INCLUDE: 1) PERIPHERAL DA INCREASES THE ACTIVITY OF DA NEURONS AND NAC DA RELEASE, REDUCES LOCOMOTOR ACTIVITY, AND PROMOTES REWARD VIA PERIPHERAL D2RS; 2) ETOH ENHANCES BLOOD DA, INHIBITS VTA GABA NEURONS, ENHANCES BRAIN DA, AND REDUCES INTOXICATION VIA PERIPHERAL D2RS; 3) ETOH INDUCES MICROGLIA ACTIVATION AND ENHANCES D2 RECEPTOR EXPRESSION ON MONOCYTES, NEURONS, AND MICROGLIA; 4) DEPLETION OF MDMS REDUCES ETOH EFFECTS ON VTA GABA NEURONS AND DA RELEASE; 5) SELECT CYTOKINES ENHANCE VTA NEURON EXCITABILITY AND DA RELEASE; 6) LAST, WE SHOW PRELIMINARY EVIDENCE OF DA AND ATP CO-RELEASE FROM DA TERMINALS, AND MOTILITY EFFECTS OF ETOH ON MICROGLIA, WHICH INDICATE FURTHER STUDY FOR POTENTIAL NAC ETOH IMMUNE INTERACTIONS IN VIVO. THESE DATA WILL PROVIDE NEW, FUNDAMENTAL KNOWLEDGE ON THE NEUROBIOLOGY OF ETOH REWARD AND DEPENDENCE AND THE ROLE OF PERIPHERAL SUBSTRATES THAT MAY HELP IMPROVE DRUG DEVELOPMENT EFFORTS. TO TEST THE HYPOTHESES, WE PROPOSE TWO SPECIFIC AIMS: 1) DEFINE THE ROLE OF PERIPHERAL NEUROIMMUNE INTERACTIONS IN ETOH EFFECTS ON VTA GABA NEURONS AND NAC DA RELEASE, AND RELATED BEHAVIORS; 2) DESCRIBE EFFECTS OF ETOH ON NAC DA TERMINALS AND MICROGLIA, CO-RELEASE OF DA AND ATP. WE WILL USE WILD-TYPE AND TRANSGENIC MOUSE MODELS (GAD67-GFP KNOCK-IN; VGAT-CHR2, VGAT-CRE/GAD67-GFP; AND MAFIA MICE) AND MDM DEPLETION TO STUDY NEUROCHEMICAL AND ELECTROCHEMICAL RECORDINGS OF DA RELEASE. CYTOMETRY TECHNIQUES WILL BE USED TO DETERMINE CYTOKINE FACTORS INVOLVED IN MESOLIMBIC ALTERATIONS. MULTIPHOTON MICROSCOPY APPROACHES TO STUDY MICROGLIA CHEMOTAXIS IN THE CONTEXT OF DA AND ATP AS MEASURED BY FAST SCAN CYCLIC VOLTAMMETRY. MULTIPHOTON MICROSCOPY WILL BE USED IN VIVO THROUGH ENDOSCOPIC RELAY GRADIENT INDEX LENSES TO STUDY GFP LABELED SATELLITE MICROGLIA SURVEILLANCE WHILE MEASURED DOPAMINE RELEASE USING A RED SHIFTED OPTICAL SENSOR FOR DETECTING DA RELEASE, WHICH WILL BE PERFORMED ON MICE UNDERGOING CHRONIC INTERMITTENT ETOH (CIE) INDUCTION, THUS DESCRIBING NEUROIMMUNE ACTIVITY FROM FIRST EXPOSURE TO ETOH, THROUGH TO DEPENDENCE. SCIENTIFIC RIGOR IS HIGH CONSIDERING THE USE OF CONVENTIONAL BEHAVIORAL, PHARMACOLOGICAL, ELECTROCHEMICAL, MICROSCOPY AND MOLECULAR TOOLS.

HIGH DENSITY 3D PRINTED MICROFLUIDICS WITH OPEN SOURCE RESINS FOR BIOMEDICAL APPLICATIONS

REFUGEES IN KAKUMA CAMP HAVE ACCESS TO PSYCHOSOCIAL SERVICES AND PROTECTION

WEARABLE NANOCOMPOSITE SENSOR SYSTEM FOR DIAGNOSING MECHANICAL SOURCES OF LOW BACK PAIN AND GUIDING REHABILITATION - PROJECT SUMMARY BACK PAIN HAS GAINED THE DISTINCTION OF BEING THE MOST DISABLING CONDITION IN THE WORLD [1-3], AFFECTING 80-90% OF THE US POPULATION AT SOME POINT IN THEIR LIFETIME, WITH 29% OF THE US POPULATION HAVING EXPERIENCED LOWER BACK PAIN WITHIN THE LAST 3 MONTHS. BACK AND NECK PAIN ARE THE LEADING CAUSE OF MISSED WORK DAYS AND RANK SECOND ONLY TO THE COMMON COLD AS A REASON FOR A VISIT TO THE DOCTOR, ACCOUNTING FOR APPROXIMATELY 30% OF GENERAL PRACTITIONER VISITS. OF PARTICULAR CONCERN IS CHRONIC LOW BACK PAIN (CLBP), WHICH IS RECURRENT AND OFTEN NON-RESPONSIVE TO CONSERVATIVE TREATMENTS. IT HAS LONG BEEN RECOGNIZED THAT SPINAL PATHOLOGY CHANGES THE WAY THAT WE MOVE. BIOMECHANISTS, PHYSICAL THERAPISTS, AND SURGEONS EACH UTILIZE A VARIETY OF TOOLS AND TECHNIQUES TO ASSESS AND INTERPRET QUALITATIVE MOVEMENT CHANGES AS A WINDOW TO UNDERSTANDING POTENTIAL MECHANICAL AND NEUROLOGICAL SOURCES OF LOW BACK PAIN AND AS A CRITICAL ELEMENT IN THEIR TREATMENT PARADIGM. HOWEVER, OBJECTIVELY CHARACTERIZING AND COMMUNICATING THIS INFORMATION IS CURRENTLY IMPOSSIBLE, SINCE CLINICALLY FEASIBLE (E.G., COST-EFFECTIVE, OBJECTIVE, AND ACCURATE) TOOLS AND QUANTITATIVE BENCHMARKS DO NOT EXIST. THIS PROPOSAL ADDRESSES THE CHALLENGE TO IMPROVE CLBP OUTCOMES THROUGH THE USE OF UNIQUE, INEXPENSIVE, SCREEN-PRINTABLE, ELASTOMER-BASED NANO-COMPOSITE PIEZORESPONSIVE SENSORS WHICH WILL BE INTEGRATED INTO A SPINAL NANOSENSOR ENVIRONMENT (SPINE SENSE SYSTEM) TO MEASURE LUMBAR KINEMATICS AND PROVIDE AN OBJECTIVE, QUANTITATIVE PLATFORM FOR DIAGNOSIS, MONITORING, AND FOLLOW-UP ASSESSMENT OF CLBP.

MASS SPECTROMETRY-BASED BIOCHEMICAL ANALYSIS OF SINGLE CELLS BEYOND THE GLOBAL PROTEOME - PROJECT SUMMARY/ABSTRACT BIOLOGICAL TISSUES EXHIBIT A HIGH DEGREE OF PHENOTYPIC HETEROGENEITY AND PLASTICITY, COMPRISING MANY DIFFERENT SUBPOPULATIONS OF CELLS IN VARIOUS STATES. QUANTIFYING THIS HETEROGENEITY AT THE SINGLE-CELL LEVEL AND WITH MOLECULAR DEPTH ACROSS LARGE NUMBERS OF CELLS AND MULTIPLE CLASSES OF MOLECULES PROVIDES INFORMATION THAT CANNOT BE OBTAINED AT THE BULK SCALE AND WILL ULTIMATELY LEAD TO IMPROVED DIAGNOSTICS AND MORE EFFECTIVE TREATMENTS. WHILE SINGLE-CELL NUCLEIC ACID SEQUENCING APPROACHES ARE HAVING A SIGNIFICANT IMPACT ON BIOMEDICAL RESEARCH, PROTEINS, LIPIDS AND METABOLITES MEDIATE THE BULK OF CELLULAR FUNCTION AND MEASUREMENT OF THEIR EXPRESSION PROVIDES MORE DIRECT INSIGHT INTO CELLULAR PHENOTYPE. THERE IS THUS AN URGENT NEED TO DEVELOP NEW TECHNOLOGIES FOR LARGE-SCALE DIRECT PROTEOME, LIPIDOME AND METABOLOME PROFILING AT THE SINGLE-CELL LEVEL. TO FILL THIS GAP, MASS SPECTROMETRY (MS)-BASED PROFILING OF PROTEIN EXPRESSION IN SINGLE CELLS HAS RECENTLY BEEN DEMONSTRATED THROUGH THE IMPLEMENTATION OF MORE EFFICIENT SAMPLE PROCESSING WORKFLOWS, NOVEL EXPERIMENTAL DESIGNS AND IMPROVED INSTRUMENT SENSITIVITY. LABEL-FREE MS-BASED PROTEOMICS CAN NOW QUANTIFY >3,000 PROTEIN GROUPS PER CELL ACROSS >4 ORDERS OF MAGNITUDE OF DYNAMIC RANGE. HERE WE PROPOSE TO APPLY MASS SPECTROMETRY TO STUDY BIOMOLECULAR EXPRESSION AT THE SINGLE-CELL LEVEL BEYOND THE GLOBAL PROTEOME. WE WILL DEVELOP GLOBAL AND TARGETED APPROACHES TO PROFILE POSTTRANSLATIONAL MODIFICATIONS IN SINGLE CELLS, BEGINNING WITH PHOSPHORYLATION. WE WILL ALSO EXTEND NANOFLOW LIQUID CHROMATOGRAPHY-MS CAPABILITIES FOR IN-DEPTH SINGLE-CELL LIPID PROFILING. ULTIMATELY, WE WILL DEVELOP NOVEL MEANS OF GENERATING COMPLEX LC GRADIENTS THAT UTILIZE MORE THAN TWO MOBILE PHASES TO EFFICIENTLY PROFILE MULTIPLE CLASSES OF BIOMOLECULES (E.G., PROTEOME AND LIPIDOME) FROM THE SAME SINGLE CELL. THESE RESEARCH DIRECTIONS WILL, IN COMBINATION WITH MATURE NUCLEIC ACID SEQUENCING STRATEGIES, PROVIDE AN UNPRECEDENTED VIEW OF CELLULAR REGULATION FROM GENOTYPE TO PHENOTYPE AT THE SINGLE-CELL LEVEL.

PHASE I IUCRC BRIGHAM YOUNG UNIVERSITY: CENTER FOR SPACE, HIGH-PERFORMANCE, AND RESILIENT COMPUTING (SHREC)

SUSTAINABLE WATER SECTOR CAPACITY DEVELOPMENT IN ALBANIA

ADVANCING THE NASA GEOGLOWS TOOLBOX FOR REGIONAL WATER RESOURCES MANAGEMENT AND DECISION SUPPORT

INTBIO: COLLABORATIVE RESEARCH: SILK PROTEIN INNOVATION AND NOVELTY (SPIN) : INTEGRATING ACROSS DISCIPLINES TO DECIPHER SILK FIBER EVOLUTION -SILK IS ONE OF NATURE?S STRONGEST AND LIGHTEST BIOMATERIALS. IT IS USED BY HUNDREDS OF THOUSANDS OF SPECIES FOR AN ARRAY OF APPLICATIONS. YET, OUTSIDE OF A FEW SPECIES, LITTLE IS KNOWN ABOUT THE GENOMIC BASIS AND MATERIAL PROPERTIES OF NATURAL SILKS. THIS PROJECT TAKES AN INTEGRATIVE APPROACH TO EXAMINE THE MOLECULAR, DEVELOPMENTAL, AND FUNCTIONAL BASIS OF SILK ACROSS A DIVERSITY OF USES. AN INTEGRATIVE TEAM OF NATURAL HISTORIANS, MOLECULAR BIOLOGISTS, DEVELOPMENTAL BIOLOGISTS, AND BIOENGINEERS ARE COMBINING THEIR EXPERTISE TO GAIN INSIGHT INTO HOW NATURE SHAPES SILK FIBER FUNCTION. THIS RESEARCH IS FOUNDATIONAL TO ENGINEERING NEW MATERIALS THAT CAN APPLIED TO MANY PRODUCTS, FROM SURGICAL ADHESIVES TO SUSTAINABLE CLOTHING. AS PART OF THIS PROJECT, MULTIPLE POSTDOCTORAL RESEARCHERS AND GRADUATE STUDENTS GAIN INTERDISCIPLINARY TRAINING IN GENOMICS, GENE EDITING, AND ENGINEERING. FURTHERMORE, THIS PROJECT CREATES A TRAVELING MUSEUM EXHIBIT TO EDUCATE THE PUBLIC ABOUT THE NATURAL PROPERTIES OF SILK. SILK HAS BEEN SHAPED AND RE-ADAPTED FOR AN EXTRAORDINARY DIVERSITY OF USES ACROSS MULTIPLE DISTANTLY RELATED ARTHROPOD GROUPS AND HUNDREDS OF MILLIONS OF YEARS OF EVOLUTION. TO DATE, SILK RESEARCH IN INSECTS HAS FOCUSED LARGELY ON FIBERS FROM THE DOMESTICATED SILKWORM MOTH, BOMBYX MORI. THIS PROJECT USES A COMPARATIVE, MULTI-TIERED APPROACH TO STUDY SILKS OF THE MOST DOMINANT CLADE OF SILK-PRODUCING INSECTS, THE CADDISFLIES AND MOTHS. THE COMBINATION OF GENOMICS, PROTEOMICS, FUNCTIONAL GENETICS, AND BIOPHYSICAL MEASUREMENTS WILL ILLUMINATE HOW SILKS ADHERE TO UNDERWATER SUBSTRATES, HOW THEY CONSOLIDATE INTO AN INSOLUBLE FIBER, AND HELP UNDERSTAND THE MOLECULAR BASIS OF THEIR MECHANICAL PROPERTIES. EVOLUTIONARY CORRELATIONS ARE WOVEN BETWEEN GENOTYPES AND PHENOTYPES AND DIRECT TESTS OF CAUSALITY ARE CONDUCTED IN STRATEGICALLY CHOSEN FOCAL SPECIES THAT ARE AMENABLE TO GENETIC MODIFICATION. OVERALL, THIS PROJECT ADDRESSES THE OVERARCHING QUESTION, ?HOW DOES NATURE SHAPE SILK FIBER FUNCTION?? WITH A NEW FRAMEWORK FOR A FUNDAMENTAL BIOLOGICAL SUPERSTRUCTURE THAT HAS UNTAPPED POTENTIAL FOR THE PRODUCTION OF NEW POLYMER-BASED BIOMATERIALS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

2018-2022 CENTER FOR INTERNATIONAL BUSINESS EDUCATION GRANT

THIS AWARD FUNDS THE APPROVED 2022?23 PUBLIC HEALTH AMERICORPS PROGRAM. NO MEMBER MAY ENROLL PRIOR TO THE APPROVED START DATE OF THE MEMBER ENROLLMENT PERIOD. YOUR 2022?23 REGULATORY MATCH IS 0%. JESUIT VOLUNTEER CORPS NORTHWEST PROPOSES TO HAVE 20 AMERICORPS MEMBERS WHO WILL ACCOMPANY INDIVIDUALS WITH BARRIERS TO ACCESSING HEALTH CARE, BY CONDUCTING OUTREACH, NAVIGATING SERVICE OPTIONS, AND OFFERING COMPANIONSHIP IN 20 NONPROFIT, HEALTH CARE CONSORTIUM SITES IN RURAL AND URBAN ECONOMICALLY CHALLENGED COMMUNITIES IN ALASKA, IDAHO, MONTANA, OREGON, AND WASHINGTON. AT THE END OF THE FIRST PROGRAM YEAR, THE PUBLIC HEALTH AMERICORPS MEMBERS WILL BE RESPONSIBLE FOR THE IMPROVED ACCESS TO MEDICAL CARE FOR 2,000 MARGINALIZED INDIVIDUALS. IN ADDITION, THE AMERICORPS MEMBERS WILL LEVERAGE 500 VOLUNTEERS WHO WILL BE ENGAGED IN HEALTH CARE ACCOMPANIMENT. AFTER THEIR FIRST YEAR OF SERVICE, 10 AMERICORPS MEMBERS WILL PURSUE FUTURE ENGAGEMENT IN THE PUBLIC HEALTH SECTOR.

INCREASED ACCESS TO PROTECTION. SAFE SHELTER. AND LIVELIHOODS FOR COLOMBIAN AND VENEZUELAN REFUGEES AND MIGRANTS

PANDEM-SIM: SAVING THE WORLD WITH BIOLOGY

DEVELOPMENT OF ENABLING TECHNOLOGIES FOR A PRESSURIZED DRY FEED OXY-COAL REACTOR

CENTERS FOR INTERNATIONAL BUSINESS EDUCATION

3D-PRINTED INTEGRATED MICROFLUIDIC DEVICES FOR PRETERM BIRTH BIOMARKER ANALYSIS

THE CAUSES OF GEOGRAPHIC VARIATION IN DROSOPHILA MELANOGASTER MICROBIOTA COMPOSITION

PERFORM FUNDING SYS

HELPING PRODUCERS IMPROVE WILDLIFE HABITAT WITH INNOVATIVE SED COATING TECHNOLOGIES

MRI: DEVELOPMENT OF A LOCAL AIR TRAFFIC INFORMATION SYSTEM (LATIS) FOR UAS COLLISION AVOIDANCE RESEARCH

EXPANDING THE CAPABILITIES AND USAGE OF THE TELSAM PROTEIN CRYSTALLIZATION CHAPERONE - THERE IS A CRITICAL NEED FOR NEW PROTEIN CRYSTALLIZATION METHODS THAT ARE MORE SUCCESSFUL AND REQUIRE LESS LABOR, TIME, AND RESOURCES. LACK OF STRAIGHTFORWARD METHODS TO SUCCESSFULLY CRYSTALLIZE ANY PROTEIN OF INTEREST SIGNIFI- CANTLY HINDERS STUDY OF MOLECULAR DISEASE MECHANISMS AND THE DEVELOPMENT OF EFFECTIVE TREATMENTS. THIS LACK OF EFFECTIVE TREATMENTS FOR MANY DISEASES FORCES THEM TO BE ADDRESSED INSTEAD WITH COSTLY SYMPTOM MANAGEMENT PROGRAMS. OVER THE PAST FOUR YEARS, WE HAVE INVESTIGATED TELSAM, A NOVEL POLYMER-FORMING PROTEIN CRYSTALLIZA- TION CHAPERONE. TELSAM CARRIER PROTEINS CAN BE GENETICALLY FUSED TO DISEASE PROTEINS, DRUG TARGETS, AND BIOEN- GINEERED PROTEINS. IN LOW PH CRYSTALLIZATION CONDITIONS, TELSAM-TARGET PROTEIN FUSIONS POLYMERIZE, AND THE RE- SULTING POLYMERS ZIPPER UP TO FORM CRYSTALS SUITABLE FOR X-RAY DIFFRACTION AND ATOMIC RESOLUTION STRUCTURE DETERMI- NATION. TELSAM FUSION READILY FORMS CRYSTALS OF 90% OF PROTEINS OF INTEREST (A STARK IMPROVEMENT OVER THE 30% CRYSTALLIZATION RATE OF TRADITIONAL METHODS) AND ROUTINELY AT PROTEIN CONCENTRATIONS OF 1 MG/ML (PROMISING TO ENABLE THE STRUCTURE DETERMINATION OF PROTEINS THAT CAN ONLY BE PRODUCED IN MINUTE QUANTITIES). TELSAM FUSION CRYSTAL- LOGRAPHY THUS HAS THE POTENTIAL TO REVOLUTIONIZE THE SMALL MOLECULE AND BIOLOGIC THERAPEUTIC INDUSTRIES BY ACCEL- ERATING STRUCTURE DETERMINATION STEPS, CURRENTLY A BOTTLENECK. FOR TELSAM TO REALIZE THIS POTENTIAL, ACADEMIC AND INDUSTRIAL STRUCTURE BIOLOGISTS NEED 1) EXPERIMENTALLY VALIDATED GUIDING PRINCIPLES FOR THE USE OF TELSAM, 2) A SUFFICIENT NUMBER OF SUCCESSFUL USE CASES TO DEMONSTRATE GENERAL EFFICACY, AND 3) DEMONSTRATION OF THE APPLICA- TIONS AND LIMITS OF TELSAM FUSION CRYSTALLIZATION. THUS FAR WE HAVE RIGOROUSLY INVESTIGATED THE GUIDING PRINCIPLES FOR TELSAM’S USE AND BEGUN TO DEMONSTRATE ITS USEFULNESS WITH PROTEINS RELEVANT IN HUMAN DISEASE. OUR GOALS FOR THE NEXT FIVE YEARS ARE TO RIGOROUSLY ADDRESS THE ABOVE THREE NEEDS AND BROADLY DISSEMINATE OUR FINDINGS TO THE STRUCTURAL BIOLOGY COMMUNITY. THE OVERALL VISION OF OUR RESEARCH PROGRAM IS FOCUSED ON PUSHING THE LIMITS OF PROTEIN ENGINEERING AND STRUCTURE DETERMINATION FIELDS WHILE AT THE SAME TIME DEVELOPING UNDERGRADUATE AND GRADUATE STUDENTS, INCLUDING THOSE FROM UNDERREPRESENTED BACKGROUNDS, INTO EXCELLENT BIOCHEMISTS. WE DO THIS BY PUTTING THEM AT THE FRONT LINES OF GROUNDBREAKING RESEARCH. BOTH UNDERGRADUATE AND GRADUATE STUDENTS IN OUR GROUP PARTICIPATE IN ALL PARTS OF SCIENTIFIC INQUIRY, INCLUDING REAGENT PREPARATION, EXPERIMENT DESIGN AND EXECUTION, DATA COLLECTION AND ANALYSIS, AND MANUSCRIPT PREPARATION AND PRESENTATION AT NATIONAL AND INTERNATIONAL MEETINGS. THE PROPOSED RESEARCH IS SIGNIFICANT BECAUSE IT WILL ACCELERATE THE SUCCESSFUL STRUCTURE DETERMINATION OF A GREATER NUMBER AND VARIETY OF BIOTECHNOLOGY AND DISEASE-RELEVANT PROTEINS, DRUGS, AND BIOLOGICS, ULTIMATELY LEADING TO NEW BIOTECHNOLOGY TOOLS, MORE EFFECTIVE DISEASE TREATMENTS, AND REDUCED HEALTHCARE COSTS.

MRI: ACQUISITION OF THE LANGUAGELENS FOR LARGE-SCALE LANGUAGE MODELING -MACHINE LEARNING IS REVOLUTIONIZING MANY PARTS OF SOCIETY, BUT TRAINING THE VERY BEST MODELS REQUIRES TREMENDOUS COMPUTING RESOURCES THAT ARE OFTEN OUT OF REACH FOR ACADEMIC GROUPS. THIS PROJECT THEREFORE ACQUIRES A SPECIAL-PURPOSE INSTRUMENT, NAMED THE LANGUAGELENS, THAT IS DESIGNED TO PROCESS VAST AMOUNTS OF NATURAL LANGUAGE TEXT. THE LANGUAGELENS WILL SUPPORT RESEARCH IN NATURAL LANGUAGE PROCESSING, DEEP LEARNING, COMPUTATIONAL LINGUISTICS, CRISIS INFORMATICS, CONVERSATIONAL AI, NEURAL MACHINE TRANSLATION, AND LEGAL CORPUS LINGUISTICS, AND WILL ENABLE ACADEMIC RESEARCH TO ADVANCE BOTH THE MACHINE LEARNING NEEDED TO TRAIN LARGE MODELS, AS WELL AS SOCIETIALLY RELEVANT APPLICATIONS OF THOSE MODELS. THE LANGUAGELENS IS A HIGH-PERFORMANCE GPU CLUSTER THAT BALANCES COMPUTE, STORAGE AND INTERNODE COMMUNICATION TO SUPPORT A VARIETY OF DEMANDING NLP-BASED WORKLOADS. THE LANGUAGELENS WILL BE FOCUSED ON SOLVING RESEARCH PROJECTS THAT HAVE THE POTENTIAL FOR TRANSFORMATIONAL, INTERDISCIPLINARY IMPACT ACROSS A WIDE VARIETY OF FIELDS. A KEY AREA OF FOCUS FOR THE INSTRUMENT IS THE ABILITY TO TRAIN NEW LARGE-SCALE LANGUAGE MODELS AND TO EXAMINE THEIR INNER WORKINGS IN REAL-TIME. LANGUAGE MODELS WILL BE TRAINED WITH SPECIFIC DOWNSTREAM APPLICATIONS IN MIND, ON NOVEL CORPORA AS WELL AS WITH NOVEL NEURO-SYMBOLIC ARCHITECTURES, TO HELP DERIVE INSIGHT FROM THE RESULTING WEIGHTS. THE LANGUAGELENS WILL PRIORITIZE SUPPORT FOR RESEARCH THAT ADDRESSES PRESSING SOCIETAL PROBLEMS. IT WILL ALSO PROVIDE AUTHENTIC WORKFORCE TRAINING AND EDUCATIONAL EXPERIENCES FOR STUDENTS: AS THE RESOURCE GAP BETWEEN INDUSTRY AND ACADEMIA GROWS, IT IS INCREASINGLY DIFFICULT TO GIVE THEM OPPORTUNITIES TO PURSUE HIGH-IMPACT RESEARCH THAT INVOLVES HUGE MODELS AND DATASETS. FINALLY, AS MANY COMPANIES REFUSE TO RELEASE THE PRETRAINED WEIGHTS OF THEIR MODELS, A CENTRAL GOAL IS TO MAKE TRAINED WEIGHTS FREELY AVAILABLE TO EVERYONE, SUBJECT TO ETHICAL CONSIDERATIONS, TO DRIVE NATIONAL IMPACT FOR BOTH INDUSTRY AND ACADEMIA. PROJECT RESOURCES SUCH AS CODE, PUBLICATIONS, DATASETS AND PRETRAINED MODELS WILL BE AVAILABLE THROUGH THE LANGUAGELENS WEBSITE AT HTTPS://LL.CS.BYU.EDU/. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

SAVING LIVES CAMARILLO

THRIVING IN A DIGITAL WORLD: EXAMINING TRAJECTORIES OF HEALTHY AND PROBLEMATIC MEDIA USE IN EARLY CHILDHOOD

HEALTH CENTER INFRASTRUCTURE SUPPORT

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

COLLABORATIVE RESEARCH: QUANTIFYING CURRICULAR REASONING AS A CRITICAL PRACTICE IN TEACHING MATHEMATICS -TEACHERS OF MATHEMATICS ENGAGE IN CURRICULAR REASONING AS THEY DESIGN AND INTERACT WITH THEIR STUDENTS, CHOOSE CURRICULAR MATERIALS, AND IMPLEMENT CURRICULUM STANDARDS IN THE SERVICE OF HIGH-QUALITY INSTRUCTION. CURRENTLY, THERE IS NO SHARED MEASURE OF CURRICULAR REASONING OF MIDDLE SCHOOL TEACHER CLASSROOM DECISION MAKING IN MATHEMATICS. IN THIS RESEARCH PROJECT, THE TEAM DEVELOPS AND VALIDATES TWO MEASURES OF MIDDLE SCHOOL TEACHERS? CURRICULAR REASONING IN MATHEMATICS AS PRACTICED. THE FIRST MEASURE LOOKS AT CURRICULUM REASONING FROM THE PERSPECTIVE OF THE TEACHER, THE SECOND MEASURE ATTENDS TO THE PERSPECTIVES OF THE MATHEMATICS EDUCATION RESEARCH COMMUNITY. THE RESEARCH EXAMINES TEACHER SELF-ASSESSMENT COMPARED AND ALIGNED WITH THOSE OF PROFESSIONAL OBSERVERS (E.G., COACHES, SCHOOL LEADERS, AND RESEARCHERS) TO ESTABLISH THE VALIDITY OF THE TEACHER SELF-REPORT MEASURE. THE RESEARCH ESTABLISHES BENCHMARK SCORES OF TEACHERS CURRICULAR REASONING IN MIDDLE SCHOOL MATHEMATICS, SUPPORTING INCREASED INTERPRETABILITY AND UTILITY OF THE CURRICULAR REASONING SCORE TO IMPROVE CLASSROOM PRACTICE. THE RESEARCHERS CAREFULLY EXAMINE FOUR RESEARCH QUESTIONS: [1] TO WHAT EXTENT DOES VALIDITY EVIDENCE SUPPORT USE OF THE CURRICULAR REASONING SELF-ASSESSMENT SURVEY SUITE FOR MIDDLE SCHOOL MATHEMATICS TEACHERS TO MEASURE THEIR OWN CURRICULAR REASONING? [2] TO WHAT EXTENT DOES VALIDITY EVIDENCE SUPPORT USE OF THE CURRICULAR REASONING OBSERVATION ASSESSMENT TO MEASURE MIDDLE SCHOOL MATHEMATICS TEACHERS? CURRICULAR REASONING? [3] IS THERE A SIGNIFICANT RELATIONSHIP BETWEEN MIDDLE SCHOOL MATHEMATICS TEACHERS? CURRICULAR REASONING WHEN MEASURED BY THE NEW CURRICULAR REASONING TOOLS? [4] WHAT BENCHMARKS DEFINE DIFFERENT CURRICULAR REASONING LEVELS ON EACH OF THE TWO MEASURES? THE RESEARCH TEAM GATHERS VALIDITY DATA BASED ON SHARED STANDARDS HELD BY THE AMERICAN PSYCHOLOGICAL ASSOCIATION, THE NATIONAL COUNCIL ON MEASUREMENT IN EDUCATION, AND THE AMERICAN EDUCATIONAL RESEARCH ASSOCIATION. THE RESEARCH ADVANCES OUR UNDERSTANDING OF TEACHER CURRICULAR REASONING THROUGH THE DEVELOPMENT OF THE TWO MEASURES. THE WORK BRIDGES RESEARCH AND PRACTICE AS THE RESEARCHERS USE SELF-REPORT AND OBSERVATIONAL EVIDENCE TO SUPPORT AND IMPROVE TEACHERS? PRACTICE OF CURRICULAR REASONING. THE TEAM USES RASCH PSYCHOMETRIC TOOLS FOR STANDARD SETTING TO IMPROVE THE USABILITY OF THE MEASURES FOR CLASSROOM USAGE. THE DISCOVERY RESEARCH PREK-12 PROGRAM (DRK-12) SEEKS TO SIGNIFICANTLY ENHANCE THE LEARNING AND TEACHING OF SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) BY PREK-12 STUDENTS AND TEACHERS, THROUGH RESEARCH AND DEVELOPMENT OF INNOVATIVE RESOURCES, MODELS, AND TOOLS. PROJECTS IN THE DRK-12 PROGRAM BUILD ON FUNDAMENTAL RESEARCH IN STEM EDUCATION AND PRIOR RESEARCH AND DEVELOPMENT EFFORTS THAT PROVIDE THEORETICAL AND EMPIRICAL JUSTIFICATION FOR PROPOSED PROJECTS.? THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

CENTER OF EXCELLENCE FOR COMMAND CONTROL AND INTEROPERABILITY

SECONDARY EDUCATION FOR SUDANESE REFUGEES IN EASTERN CHAD

PERFORM FUNDING SYS

3D TEMPERATURE CONTROL TO STUDY BIOLOGICAL PROCESSES

TO PROVIDE AND STRENGTHEN CHILD PROTECTION INTERVENTIONS AND ADDRESS THE MENTAL HEALTH AND PSYCHOSOCIAL NEEDS OF URBAN REFUGEES, ASYLUM SEEKERS, AND HOST COMMUNITY MEMBERS IN ADDIS ABABA, ETHIOPIA.

MECHANISMS OF CHAPERONE-MEDIATED FOLDING OF BETA-PROPELLER PROTEINS ESSENTIAL FOR VISION. - PROJECT SUMMARY THE CYTOSOLIC CHAPERONIN CCT IS A LARGE PROTEIN COMPLEX THAT PLAYS AN INDISPENSABLE ROLE IN MAINTAINING THE CELLULAR PROTEOME BY ASSISTING IN THE FOLDING OF NUMEROUS PROTEINS WITH COMPLEX TERTIARY STRUCTURES AND UNFAVORABLE FOLDING TRAJECTORIES. PROPER CCT FUNCTION IS VITAL TO HUMAN VISION AS EVIDENCED BY THE FACT THAT INACTIVATING MUTATIONS IN CCT CAUSE LEBER CONGENITAL AMAUROSIS (LCA). CCT CONTRIBUTES TO THE VISUAL PROCESS BY FOLDING THE CYTOSKELETAL PROTEINS ACTIN AND TUBULIN AS WELL AS OTHER PROTEINS WITH B-PROPELLER FOLDS THAT HAVE ESSENTIAL FUNCTIONS IN VISON. THESE INCLUDE THE G PROTEIN B1 (GB1) SUBUNIT OF THE VISUAL G PROTEIN TRANSDUCIN, THE G PROTEIN B5 (GB5) SUBUNIT OF THE REGULATOR OF G PROTEIN SIGNALING 9 (RGS9) DIMER, AND THE BBS2 AND BBS7 SUBUNITS OF THE BARDET-BIEDL SYNDROME (BBS) CILIARY TRANSPORT COMPLEX, THE BBSOME. DESPITE THE IMPORTANCE OF CCT IN MAINTAINING THE PROTEOME, WE KNOW VERY LITTLE AT THE MOLECULAR LEVEL ABOUT HOW CCT ASSISTS IN THE FOLDING OF THESE B-PROPELLER PROTEINS AND HOW MUTATIONS DISRUPT FOLDING AND CAUSE DISEASE. TO ADDRESS THIS GAP IN KNOWLEDGE, WE PROPOSE TO DETERMINE THE STRUCTURES OF HUMAN GB1 AND GB5 AND THEIR DISEASE-CAUSING MUTANTS. STRUCTURES OF GB5 BOUND TO CCT AND ITS CO-CHAPERONE PHLP1 SHOW PROGRESSIVE STEP-BY-STEP FORMATION OF THE GB5 B-PROPELLER THAT REVEALS ITS FOLDING TRAJECTORY. UNRAVELING HOW CCT INFLUENCES THE FOLDING TRAJECTORY OF A B-PROPELLER PROTEIN REPRESENTS A BREAKTHROUGH IN UNDERSTANDING CHAPERONE-MEDIATED PROTEIN FOLDING. MOREOVER, APPLYING THESE SAME TECHNIQUES TO MISFOLDING AND DISEASE-CAUSING MUTANTS OF GB1 AND GB5 WILL SHOW HOW THE MUTATIONS DISRUPT THEIR FOLDING TRAJECTORIES. FINALLY, WE PROPOSE TO EMPLOY OUR BIOCHEMICAL AND HIGH RESOLUTION CRYO-EM EXPERTISE TO UNDERSTANDING BIOGENESIS OF THE BBSOME COMPLEX. A KEY STEP IN BBSOME ASSEMBLY IS THE FORMATION OF THE BBS2-BBS7 DIMER, WHICH REQUIRES BOTH CCT AND THREE CHAPERONIN- LIKE (CL-BBS) PROTEINS BBS6, BBS10 AND BBS12 TO COME TOGETHER. DESPITE THE 18 YEARS SINCE CL-BBS PROTEIN DISCOVERY AND THE PREDOMINANT ROLE THEIR MUTATIONS PLAY IN CAUSING BBS, THE MOLECULAR MECHANISM BY WHICH THE CL-BBS PROTEINS AND CCT ASSIST IN BBS2 AND BBS7 FOLDING AND BBS2-BBS7 DIMER FORMATION IS UNKNOWN. THE PROPOSED STUDIES WILL FILL THIS GAP IN KNOWLEDGE AND WILL DEEPEN UNDERSTANDING OF THE MOLECULAR DEFECTS CAUSED BY MUTATIONS IN GB SUBUNITS, BBS7 AND CL-BBS PROTEINS. THE STRUCTURAL WORK WILL ESTABLISH A FOUNDATION FOR TARGETED, STRUCTURE-BASED DRUG DESIGN TO CREATE NEW THERAPIES FOR THE RETINOPATHIES, NEUROPATHIES AND CILIOPATHIES CAUSED BY THESE MUTATIONS.

TO PROVIDE AND STRENGTHEN CHILD PROTECTION INTERVENTIONS AND ADDRESS MENTAL HEALTH AND PSYCHOSOCIAL NEEDS OF URBAN REFUGEES, ASYLUM SEEKERS AND HOST COMMUNITY MEMBERS IN ADDIS ABABA, ETHIOPIA

VENTRAL TEGMENTAL AREA GABA NEURONS: PLASTICITY & OPIATE RECEPTORS AT INHIBITORY INPUTS

TRACKING INTERGRANULAR STRAIN DYNAMICS WITH NEAR-ATOMIC SCALE COHERENT X-RAY IMAGING AT NEXT GENERATION LIGHT SOURCES

FISCAL YEAR 2024 CONSOLIDATED INNOVATIVE NUCLEAR RESEARCH. UNIVERSITY NAME: BRIGHAM YOUNG UNIVERSITY

INCREASING URBAN REFUGEES AND ASYLUM SEEKERS' ACCESS TO HEALTHCARE SERVICES IN GAUTENG

DEVELOPING A CRISPR-BASED FORWARD-GENETIC SCREENING METHOD IN EMBRYONIC ZEBRAFISH

RUI: COLLABORATIVE RESEARCH: NETWORK CLUSTER: DUST IN THE CRITICAL ZONE FROM THE GREAT BASIN TO THE ROCKY MOUNTAINS

TO PROVIDE AND STRENGTHEN CHILD PROTECTION INTERVENTIONS AND ADDRESS MENTAL HEALTH AND PSYCHOSOCIAL NEEDS OF URBAN REFUGEES, ASYLUM SEEKERS AND HOST COMMUNITY MEMBERS IN ADDIS ABABA, ETHIOPIA.

CONTINUUM OF CARE PROGRAM

RAGE TARGETING ATTENUATES SMOKE-INDUCED INFLAMMATION

2022-2026 CENTER FOR INTERNATIONAL BUSINESS EDUCATION GRANT

PURPOSE: TO PROMOTE ECONOMIC REVITALIZATION AND COMMUNITY DEVELOPMENT THROUGH INVESTMENT IN AND FINANCIAL ASSISTANCE TO COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS). ACTIVITIES TO BE PERFORMED: FINANCIAL ASSISTANCE MUST BE USED FOR FINANCIAL PRODUCTS, FINANCIAL SERVICES (REGULATED INSTITUTIONS ONLY), DEVELOPMENT SERVICES, LOAN LOSS RESERVES, AND CAPITAL RESERVES (REGULATED INSTITUTIONS ONLY), IN AN ELIGIBLE MARKET OR THE RECIPIENT’S APPROVED TARGET MARKET. END GOALS: THE GOAL OF THE FINANCIAL ASSISTANCE IS FOR CDFIS TO BUILD THEIR FINANCIAL CAPACITY TO LEND TO ELIGIBLE MARKETS AND/OR THEIR TARGET MARKETS, IN ORDER TO SERVE RURAL AND URBAN LOW-INCOME PEOPLE, AND COMMUNITIES ACROSS THE NATION THAT LACK ADEQUATE ACCESS TO AFFORDABLE FINANCIAL PRODUCTS AND FINANCIAL SERVICES. BENEFICIARIES: PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, OTHER PRIVATE INSTITUTION/ORGANIZATION. INVESTMENT AREAS AND TARGETED POPULATIONS, AS DEFINED IN 12 C.F.R. 1805. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: SPECIFIC ACTIVITIES RELATING TO BROADBAND USAGE ARE NOT KNOWN AT THE TIME OF AWARD. REASON FOR MODIFICATION: THE RIEGLE ACT (P.L. 103-325), THE STATUTE WHICH AUTHORIZES THE CDFI PROGRAM, REQUIRES THAT FINANCIAL ASSISTANCE AWARDS, INCLUDING BASE FINANCIAL ASSISTANCE (BASE-FA), DISABILITY FUNDS-FINANCIAL ASSISTANCE (DF-FA), AND PERSISTENT POVERTY COUNTIES-FINANCIAL ASSISTANCE (PPC-FA), BE MATCHED WITH FUNDS FROM NON-FEDERAL GOVERNMENT SOURCES AND COMPARABLE IN FORM AND VALUE TO THE FA AWARD. MODIFICATIONS WOULD BE REQUIRED IF THERE IS A CHANGE IN THE FORM AND/OR AMOUNT ORIGINALLY OBLIGATED FOR THE AWARD, BASED ON APPROVED MATCHING FUNDS. NOTE: MATCHING FUNDS ARE REQUIRED ONLY FOR ORGANIZATIONS APPLYING AS CATEGORY II/CORE FA APPLICANTS UNDER THE CDFI PROGRAM. MATCHING FUNDS ARE NOT REQUIRED FOR ANY NATIVE CDFI APPLICANTS OR HOUSING PRODUCTION-FINANCIAL ASSISTANCE AWARDS (HP-FA). ADDITIONALLY, MATCHING FUNDS ARE NOT REQUIRED FOR SMALL AND EMERGING CDFI ASSISTANCE (SECA) FA APPLICANTS AND HEALTHY FOOD FINANCING INITIATIVES (HFFI) FA APPLICANTS, PENDING FINAL FY 2025 APPROPRIATIONS LANGUAGE.

QUANTITATIVE CHARACTERIZATION OF ESSENTIAL TREMOR FOR FUTURE TREMOR SUPPRESSION

THE REGULATION AND TARGETING OF CELL SURVIVAL PATHWAYS IN CANCER

THEORY OF MAIN-GROUP, P-BLOCK HYDROCARBON FUNCTIONALIZATION REACTIONS

PUBLIC HOUSING CAPITAL FUND

LIVELIHOOD, PROTECTION AND PSYCHOSOCIAL SUPPORT FOR URBAN REFUGEES IN KAMPALA

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

A RE-CONFIGURABLE TESTBED FOR AUTONOMOUS HETEROGENEOUS MARINE MAPPING, SENSING, AND SEARCH

CONTINUUM OF CARE PROGRAM

FISCAL YEAR 2023 CONSOLIDATED INNOVATIVE NUCLEAR RESEARCH - BRIGHAM YOUNG UNIVERSITY

NUCLEAR ENERGY UNIVERSITY PROGRAMS - NUCLEAR ENERGY UNIVERSITY PROGRAMS CONSOLIDATED INNOVATIVE NUCLEAR RESEARCH - BRIGHAM YOUNG UNIVERSITY

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

COLLABORATIVE RESEARCH: GENEALOGY OF ODONATA (GEODE): DISPERSAL AND COLOR AS DRIVERS OF 300 MILLION YEARS OF GLOBAL DRAGONFLY EVOLUTION

ARRA - INCREASE SERVICES TO HEALTH CENTERS

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

2018 ASHA COOPERATIVE AGREEMENTS CONSTRUCTION PROJECT AND COMMODITIES

PREDICTIVE STRUCTURE-BASED GUIDELINES FOR IDENTIFYING OPTIMAL PEGYLATION SITES WITHIN PROTEINS

CYBERSURGEONS LIVE SIMULATION AND PBL DEVELOPMENT AND DISSEMINATION

IUCRC PHASE I BRIGHAM YOUNG UNIVERSITY: CENTER FOR AUTONOMOUS AIR MOBILITY AND SENSING (CAAMS) -THE WORLD?S AVIATION INDUSTRY IS MOVING TOWARDS AUTONOMOUS AIR MOBILITY AND SENSING, WHERE NEW DEVELOPMENTS IN ARTIFICIAL INTELLIGENCE, ENERGY SYSTEMS, AERODYNAMICS, STRUCTURES AND MATERIALS, ADVANCED MANUFACTURING, AND MULTIDISCIPLINARY DESIGN ARE ENABLING NEW AIR VEHICLE CONCEPTS AND NEW WAYS OF USING AVIATION IN THE DAILY TRANSPORT OF INFORMATION, PEOPLE, AND CARGO. THE CENTER FOR AUTONOMOUS AIR MOBILITY AND SENSING (CAAMS) WILL PRODUCE NEW FUNDAMENTAL ENGINEERING KNOWLEDGE, WILL DEVELOP NEW TECHNOLOGIES, AND WILL TRAIN A NEW WORKFORCE NEEDED BY POOLING THE TECHNICAL KNOW-HOW OF AMERICA?S LEADING ENGINEERING RESEARCH UNIVERSITIES WITH INNOVATIVE COMPANIES RANGING FROM STARTUPS TO LONG-ESTABLISHED LEADERS IN THE AEROSPACE INDUSTRY. CAAMS RESEARCH FOCUSES ON IMPROVING AIR VEHICLE PERFORMANCE, SUSTAINABILITY, SAFETY SYSTEMS, MANUFACTURABILITY, AND RELIABILITY BY INTEGRATING RESEARCH IN TRADITIONAL AEROSPACE FIELDS SUCH AS CONTROL, AERODYNAMICS, STRUCTURES AND MATERIALS, COMMUNICATION, AND ENERGY STORAGE WITH NEW DISCIPLINES INCLUDING ARTIFICIAL INTELLIGENCE, MACHINE LEARNING, AND ROBOTICS. BRIGHAM YOUNG UNIVERSITY?S CONTRIBUTIONS TO CAAMS INCLUDE RESEARCH SPECIALIZATIONS IN GPS-DENIED AND DEGRADED NAVIGATION, ALGORITHMS FOR AUTONOMOUS TRACKING FROM UNMANNED AIRCRAFT USING ELECTRO-OPTICAL AND INFRARED CAMERAS, GUIDANCE AND CONTROL OF ELECTRIC VERTICAL TAKE-OFF AND LANDING (EVTOL) AIRCRAFT, MULTI-VEHICLE COORDINATION AND CONTROL, UNMANNED AIRCRAFT TRAFFIC MANAGEMENT, AIRBORNE INFRASTRUCTURE MONITORING, AND EVTOL AIRCRAFT AERODYNAMIC MODELING AND DESIGN OPTIMIZATION. AUTONOMOUS AIR MOBILITY AND SENSING INCLUDES A BROAD RANGE OF VEHICLE CONCEPTS, INTEGRATED SUBSYSTEMS, SUPPORTING INFRASTRUCTURE, TRAFFIC MANAGEMENT TOOLS, AND APPLICATIONS THAT EXPLOIT INCREASINGLY AUTONOMOUS CAPABILITIES IN AVIATION. THESE AUTONOMOUS SYSTEMS HAVE THE POTENTIAL TO IMPROVE SAFETY AND RELIABILITY, REDUCE COSTS, AND ENABLE NEW MISSIONS OF NATIONAL AND GLOBAL IMPORTANCE. THE GLOBAL MARKET FOR AUTONOMOUS AIRCRAFT IS EXPECTED TO REACH $1.5 TRILLION BY 2040, AND CAAMS WILL BE A KEY ASSET IN ENHANCING US COMPETITIVENESS. CENTER RESEARCH WILL SUPPORT DOZENS OF STUDENTS EVERY YEAR, GIVING THEM HANDS-ON EXPERIENCE WITH ADVANCED AUTONOMOUS SYSTEMS AND DIRECT UNDERSTANDING OF INDUSTRY PERSPECTIVES AND NEEDS. CENTER OUTCOMES WILL BE BROADLY DISSEMINATED THROUGH ARCHIVAL PUBLICATIONS, PRESENTATIONS AT ENGINEERING AND COMPUTER SCIENCE CONFERENCES, AND TECHNICAL INTERCHANGES WITH AVIATION INDUSTRY MEMBERS. A SINGLE CENTER-WIDE DATA REPOSITORY WILL BE ESTABLISHED BY THE LEAD SITE WITH A PASSWORD-PROTECTED WEB PORTAL THAT CAN BE ACCESSED BY ALL CENTER INDUSTRY MEMBERS. PROJECT DATA WILL BE MADE AVAILABLE TO CENTER MEMBERS ANNUALLY AND WILL BE MADE AVAILABLE UPON REQUEST TO THE PUBLIC TWO YEARS AFTER THE CENTER FISCAL YEAR HAS ENDED. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

FY 2020 EXPANDING CAPACITY FOR CORONAVIRUS TESTING (ECT)

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

INCREASING URBAN REFUGEES AND ASYLUM SEEKERS ACCESS TO HEALTHCARE SERVICES IN GAUTENG

LIVELIHOOD, PROTECTION AND PSYCHOSOCIAL SUPPORT FOR URBAN REFUGEES IN KAMPALA

PROBING SHORT-RANGE STRUCTURE AND MAGNETISM IN NEXT-GENERATION ENERGY CONVERSION MATERIALS

YIP MODELING NATURAL DYNAMIC SCENES FOR AUTONOMOUS LITTORAL OPERATIONS

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** ENGINEERING FOR AGRICULTURAL PRODUCTION SYSTEMS PARTNERSHIP: THE INFLUENCE OF LEAF SHEATH ON GREENSNAP GRAIN FAILURE

SUPPORTIVE HOUSING NEW

EXPANSION OF THE 'GETTING STARTED IN CRYO-EM' COURSE INTO A COMPREHENSIVE THEORY AND PRACTICE CURRICULUM

BANGKOK URBAN REFUGEE ASSISTANCE AND PROTECTION PROJECT

REFUGEES IN KAKUMA CAMP AND KALOBEYEI HAVE ACCESS TO PSYCHOSOCIAL SERVICES AND PROTECTION

ELEMENTARY AND SECONDARY SCHOOL COUNSELING DEMONSTRATION PROGRAM

IMPROVING RESILIENCY AND REDUCING RISK OF EXTREME HYDROLOGIC EVENTS THROUGH APPLICATION OF EARTH OBSERVATIONS AND INSITU MONITORING INFORMATION

23-TTT-0032 BRINGING THE POWER OF ALGORITHMIC AND IMPLICIT DIFFERENTIATION TO OPENMDAO

CONTINUUM OF CARE PROGRAM

REAL TIME ADAPTIVE BEAMFORMING AND INTERFERENCE MITIGATION

PUBLIC AND INDIAN HOUSING

FISCAL YEAR 2023 CONSOLIDATED INNOVATIVE NUCLEAR RESEARCH - BRIGHAM YOUNG UNIVERSITY

CONTINUUM OF CARE PROGRAM

PUBLIC AND INDIAN HOUSING

CONTINUUM OF CARE PROGRAM