Collab Incorporated

ADVANCING SUSTAINABLE IMPLEMENTATION OF COMPREHENSIVE HIV/TB SERVICES FOR EPIDEMIC CONTROL IN THE REPUBLIC OF MOZAMBIQUE UNDER THE PRESIDENT'S EMERGENCY PLAN FOR AIDS RELIEF

SUPPORTING IMPLEMENTATION OF HIV AND TB SERVICES FOR EPIDEMIC CONTROL IN THE REPUBLIC OF MOZAMBIQUE

INSTITUTE FOR ADVANCED COMPOSITES MANUFACTURING INNOVATION

GH11-1130 SUPPORTING MOH TO IMPLEMENT & EXPAND COMPREHENSIVE HIV/AIDS CARE

TRANSFORMING CLINICAL PRACTICES INITIATIVE - PTN

REGIONAL EXTENSION CENTER (REC) PROGRAM TO PROMOTE THE ADOPTION AND MEANINGFUL USE OF EHRS BY PRIORITY PRIMARY CARE PROV

EXPANDING NEW YORK STATE'S HEALTH INFORMATION INFRASTRUCTURE

TRANSFORMING CLINICAL PRACTICES INITIATIVE - PTN

EARLY HEAD START CHILD CARE PARTNERSHIP

INSTITUTE FOR ADVANCED COMPOSITES MANUFACTURING INNOVATION

EARLY HEAD START

EARLY HEAD START CHILD CARE PARTNERSHIP

INVESTING IN INNOVATION - VALIDATION

EARLY HEAD START/CHILD CARE PARTNERSHIP

NEIGH STABIL PROG 2

HEALTH CENTER CLUSTER

HEALTH CENTER CLUSTER

INFRASTRUCTURE SUPPORT TO THE MOZAMBICAN HEALTH SYSTEM TO SCALE-UP HIV/AIDS AND TB SERVICES ON BEHALF OF THE PRESIDENT'S EMERGENCY PLAN FOR AIDS RELIEF (PEPFAR)

"YOUR RIGHTS" AIMS TO INCREASE HUMAN RIGHTS AWARENESS THROUGH STRATEGIC MESSAGING, BUILD DEFENSES OF HUMAN RIGHTS DEFENDERS TO SAFEGUARD CIVIC SPACE AND CREATE CITIZEN AGENCY TO DEMAND ACCOUNTABILITY

COMMUNITY PARTNERSHIPS FOR TEACHER PIPELINE

YOUTH - YOUNG OFFENDER

SCALING AN EVIDENCE-BASED NATIONAL MODEL OF INSTRUCTIONAL SYSTEMS’ SUCCESS

CCE PATHWAY TO PROSPECTIVE EDUCATOR SUCCESS

SUPER EFFICIENT APPLIANCE DEPLOYMENT INITIATIVE

RUNAWAY AND HOMELESS YOUTH TRAINING AND TECHNICAL ASSISTANCE CENTER

EARLY HEAD START - CHILD CARE PARTNERSHIP

FOA RESPONSE FOR THE REGIONAL EXTENSION CENTER FOR THE STATE OF NEW HAMPSHIRE

BASIC CENTER PROGRAM

CONTINUATION OF THE SYMPTOMS OF LOWER URINARY TRACT DYSFUNCTION RESEARCH NETWORK (LURN) DATA COORDINATING CENTER

DC FATHERHPOOD EDUCATION, EMPOWERMENT AND DEVELOPMENT PROGRAM

CMAT

AS ESTABLISHED IN THE PROPOSAL SOURCE DOCUMENTS THE SPRAGUE RIVER WATERSHED IN THE UPPER KLAMATH BASIN UKB ONCE SUPPORTED THRIVING AQUATIC RIPARIAN AND FLOODPLAIN ECOSYSTEMS AND ABUNDANT NATIVE FISH POPULATIONS IN THE ARID HIGH DESERT OF THE EASTERN CASCADES. SETTLERS WHO ARRIVED IN THE BASIN IN THE 19TH AND 20TH CENTURY CHANGED THE LANDSCAPE OFTEN UNDER DIRECTION OF THE FEDERAL GOVERNMENT AND THE LONG-TERM IMPLICATIONS TO THE NATURAL ECOSYSTEM AND THE FIRST PEOPLES WERE RARELY CONSIDERED. WATER SYSTEMS WERE ENGINEERED TO DRAIN WETLANDS CONTROL FLOODS AND DELIVER WATER. TREES WERE CLEARED FIRE SUPPRESSED AND FIRST PEOPLES MANAGEMENT OF LANDS WATERS FISH AND WILDLIFE WAS FORCED INTO MARGINS AND TO NONEXISTENCE. FURTHER CLIMATE CHANGE AND RECENT HIGH SEVERITY WILDFIRES HAVE BEEN ADDING ADDITIONAL PRESSURE TO THIS ALREADY FRAGILE SYSTEM. IN 2021 THE BOOTLEG FIRE BURNED OVER 410000 ACRES OF THE SPRAGUE BASIN EXACERBATING EXCESSIVE SEDIMENT LOADING AND LACK OF RIPARIAN HABITAT. SOILS IN THE KLAMATH BASIN ARE NATURALLY HIGH IN PHOSPHORUS SO EXCESSIVE SEDIMENT LOADING INTO THE SYSTEM FUELS ALGAE BLOOMS AND IMPAIRED WATER QUALITY CONDITIONS IN THE SPRAGUE RIVER UPPER KLAMATH LAKE AND DOWNSTREAM INTO THE MAINSTEM KLAMATH RIVER.WATERSHED HEALTH ON THE SPRAGUE RIVER IS CRITICAL TO THE LONG-TERM RECOVERY OF ESA LISTED ENDANGERED CWAAM (LOST RIVER SUCKER DELTISTES LUXATUS) KOPTU (SHORTNOSE SUCKER CHASMISTES BREVIROSTRIS) AND THREATENED BULL TROUT (SALVELINUS CONFLUENTUS) AS WELL AS ANADROMOUS SALMONIDS FOLLOWING KLAMATH DAM REMOVAL. RECOGNIZING THIS NEED AS WELL AS THE NEED TO SUPPORT ENGAGEMENT AND ECONOMIC RESILIENCE FOR LANDOWNERS OUR DIVERSE GROUP OF PARTNERS HAS AN AMBITIOUS PROPOSAL TO RESTORE THIS WATERSHED. RESTORATION AND BEST MANAGEMENT PRACTICES CAN INCREASE PROPERTY VALUE IMPROVE EFFICIENCIES REDUCE REGULATORY RISK AND SIMPLIFY MANAGEMENT MAKING FARMS AND RANCHES MORE PROFITABLE AND RESILIENT. YET ITS ALSO IMPORTANT TO ACKNOWLEDGE THAT SOME PROJECTS CAN INADVERTENTLY BURDEN LANDOWNERS WITH SLOWED PRODUCTIVITY HIGHER ENERGY COSTS LOSS OF FARMABLE SURFACE AREA OR ADDED TIME AND WAGE REQUIREMENTS. FORTUNATELY, RENEWED COMMUNITY AND PARTNER ENGAGEMENT IN THE UKB HAVE CREATED THE CONDITIONS TO ADDRESS THESE SHORTCOMINGS. THROUGH COLLABORATION WITH PARTNERS AND LANDOWNERS OUR TEAM HAS THE UNIQUE ABILITY TO ADDRESS PROGRAM PRIORITIES WITH TECHNICALLY SOUND COST-EFFECTIVE SOLUTIONS. OUR PROPOSAL WILL DEVELOP A LANDOWNER INCENTIVE FRAMEWORK THAT ENCOURAGES PARTICIPATION IN WATERSHED RESTORATION WHILE VALUING THE DIVERSE NEEDS OF LANDOWNERS IN THE WATERSHED. THIS PHASE I PROPOSAL ENCOMPASSES THREE GOALS TO ADDRESS THE CULTURAL AND LOGISTICAL BARRIERS TO ECOLOGICAL RESTORATION WHILE DEVELOPING AND MAINTAINING ECONOMIC DRIVERS IN THE KLAMATH BASIN. THE APPROACH OUTLINED BELOW WOULD PROVIDE AN EXPEDITIOUS AND DURABLE PATHWAY TO IMPLEMENT THE RECOMMENDATIONS IDENTIFIED IN THE DOI LANDSCAPE RESILIENCY FRAMEWORK KLAMATH BASIN INTEGRATED FISHERIES RESTORATION AND MONITORING PLAN UPPER KLAMATH BASIN WATERSHED ACTION PLAN AND THE U.S. FISH AND WILDLIFE SERVICES PARTNERS FOR FISH AND WILDLIFE STRATEGIC PLAN.THE SPRAGUE RIVER COLLABORATIVE RESTORATION PROJECT EMPHASIZES A COMMITMENT TO VOLUNTARY INCENTIVE WITH FEDERAL STATE AND LOCAL PROGRAM TO HELP ALL LANDOWNERS ADVANCE THEIR CONSERVATION PRIORITIES.

THE PURPOSE OF YOUTH COLLABORATORYS NATIONAL (SERVICE AREA) PILOT PROGRAM IS TO DEVELOP AND BUILD THE CAPACITY OF COMMUNITY-BASED ORGANIZATIONS (CBOS) IN UNDERSERVED COMMUNITIESTO PROVIDE SERVICES TO ADOLESCENT AND YOUTH HUMAN TRAFFICKING VICTIMS THROUGH THE PROVISION OF MENTORSHIP AND TRAINING AND TECHNICAL ASSISTANCE (TTA). THIS PROJECT WILL PRIORITIZERURAL AND UNDERSERVED COMMUNITIESINCLUDING INDIGENOUS, UNDOCUMENTED, MALE, AND LABOR TRAFFICKING SURVIVORS.PROJECT ACTIVITIES INCLUDE A NATIONAL CALL TO SELECT CBOS FOR PILOT PARTICIPATION AND SUBAWARDS, BASELINE AND ONGOING ORGANIZATIONAL CAPACITY BUILDING ASSESSMENTS, DEVELOPMENT OF INDIVIDUALIZED ORGANIZATIONAL CAPACITY BUILDING PLANS, GROUP TRAINING, ONE-ON-ONE TECHNICAL ASSISTANCE, PEER-TO-PEER LEARNING, RESOURCE DEVELOPMENT AND DISSEMINATION, ANNUAL SUBAWARDEE GATHERING, NATIONAL LEARNING SERIES, AND ONGOING MONITORING.YOUTH COLLABORATORYS PARTNER AND SUBRECIPIENT, RURAL OPPORTUNITY INSTITUTE, WILL HELP BUILD THE CAPACITY OF RURAL COMMUNITIES TO SUPPORT PEOPLES HEALING FROM GENERATIONAL TRAUMA TO ACHIEVE HEALTH, SAFETY, CONNECTION, AND SELF-DETERMINATION. YOUTH COLLABORATORY WILL ALSO PARTNERWITH OTHER NATIONAL TTA PROVIDERS AND SUBJECT MATTER EXPERTS TOSHARE STRATEGIES AND DISSEMINATE BEST PRACTICES, AND ITS GIRLS ACTION BOARD AND YOUTH CATALYST TEAM, WHO ARE LIVED EXPERIENCE EXPERTS, WILL CONSULT ON THE CONTENT AND PROVIDE TTA.

VISTA STATE

ACTION, IMPLEMENTATION, MITIGATION PROGRAM AND COMMUNITY MITIGATION ASSISTANCE TEAM

COMMUNITY COMPASS TECHNICAL ASSISTANCE AND CAPACITY BUILDING

SCALING EXCELLENCE IN THE DEFENSE INDUSTRYS COMPOSITES MANUFACTURING WORKFORCE

SCHOOL LEADERSHIP PROGRAM

THE UGANDA HOUSING MODIFICATION STUDY (UHMS) SEEKS TO EXPLORE HOUSING MODIFICATION AS A MALARIA CONTROL INTERVENTION, AND TO ASSESS THE DEGREE TO WHICH IT MAY OFFER PROTECTION IN MODERATE TO HIGH MALARIA ENDEMICITY SETTINGS. THE STUDY WILL GENERATE KNOWLEDGE ABOUT THE EFFECTIVENESS OF HOUSING MODIFICATION IN REDUCING EPIDEMIOLOGIC INDICATORS OF MALARIA INCIDENCE, PREVALENCE, AND BURDEN AND ENTOMOLOGIC MEASURES IN SETTINGS OF MODERATE TO HIGH MALARIA ENDEMICITY. THE PURPOSE OF THE “ENHANCED ENTOMOLOGICAL SURVEILLANCE” IS TO INCREASE THE SCALE OF ENTOMOLOGICAL MONITORING ACTIVITIES, BUILD THE CAPACITY OF DISTRICTS TO CONDUCT THIS MONITORING, AND STRENGTHEN THE LINK BETWEEN CLINICAL AND ENTOMOLOGICAL SURVEILLANCE. THIS ACTIVITY FURTHER SEEKS TO BUILD THE CAPACITY OF DISTRICT VECTOR CONTROL OFFICERS (VCOS) TO CARRY OUT MOSQUITO COLLECTION AND BASIC ENTOMOLOGICAL ANALYSIS THROUGHOUT THE COUNTRY IN COORDINATION WITH OTHER PARTNERS WORKING ON ENTOMOLOGY

EXPANSION OF SYMPTOMS OF LOWER URINARY TRACT DYSFUNCTION RESEARCH NETWORK (LURN)

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

GREATER CINCINNATI ACCOUNTABLE HEALTH COMMUNITIES - TRACK 3 - ALIGNMENT

COOPERATIVE AGREEMENT TO SUPPORT NAVIGATORS IN FEDERALLY-FACILITATED EXCHANGES

THE PROPOSED COOPERATIVE AGREEMENT SHALL BE FOR THE PURPOSE OF MAINTAINING THE EXISTING RESEARCH PARTNERSHIP BETWEEN THE NASA AMES RESEARCH CENTER (N

MENTORING CHILDREN OF PRISONERS TRAINING & TECHNICAL ASSISTANCE

SEE NOTICE OF AWARD, ATTACHMENT 1 - TERMS AND CONDITIONS, ATTACHMENT D, STATEMENT OF WORK, ABSTRACT.

YOUTH COLLABORATORY MENTORING PROGRAM

MANUFACTURE OF AN INTRACEREBROVENTRICULAR ENZYME REPLACEMENT THERAPY FOR CLN1 BATTEN DISEASE - SUMMARY THE NEURONAL CEROID LIPOFUSCINOSES (NCLS) ARE A GROUP OF INCURABLE NEURODEGENERATIVE STORAGE DISORDERS PRIMARILY AFFECTING THE BRAIN AND THE RETINA OF CHILDREN AND YOUNG ADULTS, LEADING TO DEMENTIA, BLINDNESS, EPILEPSY, AND EARLY DEATH, WITH A PREVALENCE OF APPROXIMATELY 1.5 TO NINE PER MILLION POPULATION (1.3 TO 7 PER 100,000 LIVE BIRTHS). THE INFANTILE ONSET FORM CLN1 DISEASE IS CAUSED BY MUTATIONS IN THE CLN1/PPT1 GENE, WHICH CODES FOR THE LYSOSOMAL ENZYME PALMITOYL-PROTEIN THIOESTERASE-1 (PPT1) RESULTING IN A REDUCTION OR ABSENCE OF ENZYME ACTIVITY. CLN1 DISEASE USUALLY PRESENTS BETWEEN 6 AND 24 MONTHS OF AGE AND THERE ARE 2-3 CHILDREN WITH THIS FORM IDENTIFIED EACH YEAR AND CURRENTLY 24 KNOWN CHILDREN WITH CLN1 IN THE US, 11 IN BRAZIL AND AT LEAST 10 IN THE UK (WITH LIKELY MANY MORE UNDIAGNOSED). THERE ARE CURRENTLY NO TREATMENTS AVAILABLE OTHER THAN PALLIATIVE THERAPIES AND THE DISEASE IS FATAL. HUMAN RECOMBINANT PPT1 (RHPPT1) EXPRESSED IN CHO CELLS HAS BEEN PREVIOUSLY REPORTED TO MODIFY DISEASE PHENOTYPES FOLLOWING A SINGLE INTRATHECAL (IT) AND INTRAVENOUS (IV) ADMINISTRATION IN PPT1 DEFICIENT MICE (PPT1-/-). AFTER SUCCESSFUL COMPLETION OF OUR PHASE I SBIR IN WHICH WE EXCEEDED OUR MILESTONES MONTHLY INTRACEREBROVENTRICULAR (ICV) ADMINISTRATION OF RHPPT1 PRODUCED STATISTICALLY SIGNIFICANT TREATMENT EFFECTS IN PPT1-/- MICE, SUCH AS RESCUE OF MORE THAN 60% PPT1 ENZYME ACTIVITY DECREASED SECONDARY ENZYME LEVELS, DECREASED THE LOSS OF NEURONS IN ALL REGIONS OF BRAIN AND SPINAL CORD AND IMPROVED GAIT AND ROTAROD RESULTS. THE CLN1 ERT DATA CLEARLY POINTED TO ICV DOSING AS IDEAL FOR FUTURE STUDIES, WHICH IS ALSO A PREFERRED ROUTE ACCORDING TO PHYSICIANS. OUR PHASE II SBIR HAS ENABLED US TO 1. PREPARE OUR QUALITY DOCUMENTS, 2 IDENTIFY A CDMO (STC BIOLOGICS) WHO HAS MANUFACTURED OUR GLP QUALITY PROTEIN FOR PREIND TOXICITY STUDIES IN RAT. 3. SUBMITTED A PREIND REQUEST TO THE FDA (WITH THE ASSISTANCE OF RTI INTERNATIONAL,). WE NOW PROPOSE IN THIS PROJECT 1. PRODUCTION OF GMP PROTEIN (WITH STC BIOLOGICS), 2. CONTINUED DEVELOPMENT OF QUALITY PROCEDURES, 3. PREPARE A CLINICAL TRIAL PROTOCOL (WITH ASSISTANCE FROM CTI CLINICAL TRIAL SERVICES, INC.), 4 AND SUBMIT AN IND (WITH ASSISTANCE FROM RTI). THESE COLLABORATIONS WILL ENABLE US TO COST EFFECTIVELY AND MORE RAPIDLY TRANSLATE THIS POTENTIAL TREATMENT TO THE CLINIC THAT CAN POTENTIALLY SAVE THE LIVES OF CHILDREN LIVING WITH THIS DEVASTATING DISEASE. WE HAVE ALREADY OBTAINED AN ORPHAN DRUG DESIGNATION AND RARE PEDIATRIC DISEASE DESIGNATION FROM THE FDA FOR RHPPT1 AS A BIOLOGICAL PRODUCT FOR A “RARE PEDIATRIC DISEASE” WHICH OFFERS SEVERAL BENEFITS IN FUTURE UPON FDA APPROVAL, INCLUDING MARKETING EXCLUSIVITY FOR 7 YEARS AND THE POTENTIAL TO OBTAIN A RARE PEDIATRIC DISEASE VOUCHER AND THUS PROVIDE A RETURN ON INVESTMENT (CURRENT VALUE ~$100 M). WE ARE ENGAGED WITH CLN1 FAMILIES AND WE ARE NOW WELL POSITIONED TO CONTINUE THE DEVELOPMENT OF THIS POTENTIAL TREATMENT FOR A DEVASTATING DISEASE. THIS PROPOSED WORK WOULD BRING US CLOSER TO A CLINICAL TRIAL. OUR WORK ON DEVELOPING RHPPT1 AS AN ERT FOR CLN1 WOULD POSITION US WELL TO WORK ON FURTHER RARE DISEASES IN FUTURE AND GROW CPI. THERE IS AN IMPORTANT ROLE TO BRING TREATMENTS TO PATIENTS WITH ULTRA-RARE DISEASES AS ILLUSTRATED BY OTHER MUCH LARGER COMPANIES SUCH AS BIOMARIN AND ULTRAGENYX WHO WE ASPIRE TO EMULATE.

COMMUNITY NAVIGATORS PROGRAM

SCHOOL LEADERSHIP PROGRAM

PARENT INFORMATION AND RESOURCE CENTERS - PARENTAL INFORMATION AND RESOURCE CENTERS

HERWITZ STANLEY/UAV COLLABORATIVECOOPERATIVE RESEARCH ON UNMANNED AERIAL SYSTEMS (UAS)THE PROPOSED

CENTRALIZED ASSAY DATASETS FOR MODELLING SUPPORT OF SMALL DRUG DISCOVERY ORGANIZATIONS

COOPERATIVE AGREEMENT TO SUPPORT NAVIGATORS IN FEDERALLY-FACILITATED EXCHANGES - BEXAR COUNTY COMMUNITY HEALTH COLLABORATIVE PATHWAY TO COVERAGE NAVIGATORPROGRAM

EARLY HEAD START - CHILD CARE PARTNERSHIP

PULESA-UGANDA-STRENGTHENING THE BLOOD PRESSURE CARE AND TREATMENT CASCADE FOR UGANDANS LIVING WITH HIV-IMPLEMENTATION STRATEGIES TO SAVE LIVES - PROJECT SUMMARY CHRONIC HIV INFECTION IS A WELL-ESTABLISHED RISK FACTOR FOR CARDIOVASCULAR DISEASE. IN SUB-SAHARAN AFRICA)—A REGION THAT MAY ACCOUNT FOR HALF OF THE GLOBAL BURDEN OF CVD ATTRIBUTABLE TO HIV—HYPERTENSION IS THE MOST IMPORTANT DRIVER OF CVD RISK. PROFOUND BARRIERS TO EFFECTIVE HYPERTENSION MANAGEMENT EXIST, INCLUDING LIMITED KNOWLEDGE, INCONSISTENT BP MEASUREMENT, AND POOR ACCESS TO MEDICATIONS. HIV CARE INNOVATIONS SUCH AS ACCESS TO NO-COST ANTIRETROVIRAL THERAPY, DIFFERENTIATED SERVICE DELIVERY AND USE OF PLHIV PEERS IN CARE MODELS MAY IMPROVE CARE OF COMORBID CONDITIONS SUCH AS HYPERTENSION. THE OVERARCHING GOAL OF PULESA-UGANDA STUDY IS TO IMPROVE THE BP TREATMENT CASCADE FOR PEOPLE LIVING WITH HIV (PLHIV) IN URBAN AND PERI-URBAN UGANDA IN A SCALABLE AND SUSTAINABLE MANNER. THIS HYBRID IS TYPE 3 STUDY PROPOSES TO FIRST EXPLORE CURRENT PRACTICE, ROUTINES, BARRIERS, AND FACILITATORS OF EVIDENCE–BASED BP CARE IN HIV CLINICAL SETTINGS IN KAMPALA AND WAKISO DISTRICTS (AIM 1). THEN, USING A HUMAN-CENTERED DESIGN APPROACH, A DESIGN TEAM OF KEY STAKEHOLDERS WILL USE DATA FROM THE FORMATIVE ASSESSMENT TO DEVELOP A MULTI-COMPONENT IMPLEMENTATION STRATEGY (HTN-PLUS) TO IMPROVE UPTAKE AND ADHERENCE TO EVIDENCE-BASED BP TREATMENTS, CONTEXTUALLY ADAPTED TO THESE UGANDAN HIV CLINICS (SUB-AIM 1.1). THE DESIGN TEAM WILL ADAPT DIFFERENTIATED SERVICE DELIVERY MODELS, USE OF HYPERTENSIVE PLHIV PEER CHAMPIONS, AND METHODS OF BP MONITORING THAT ADDRESS SPECIFIC BARRIERS AND FACILITATORS OF BP CARE. IN A STEPPED-WEDGE CLUSTER RANDOMIZED TRIAL OF 16 CLINICS FROM KAMPALA AND WAKISO, WE WILL DETERMINE THE EFFECTIVENESS OF IMPLEMENTATION STRATEGIES TO IMPROVE BP CASCADE METRICS (AIM 2). CLINICS WILL BE RANDOMIZED TO RECEIVE FREE AND CONSISTENT ACCESS TO DIAGNOSTIC EQUIPMENT AND EVIDENCE-BASED ANTIHYPERTENSIVE DRUGS (HTN-BASIC) WITH AND WITHOUT THE MULTI-COMPONENT IMPLEMENTATION STRATEGY DEVELOPED IN SUB-AIM 1 (HTN-PLUS). THE PRIMARY EFFECTIVENESS OUTCOME WILL BE % OF PATIENTS WITH HYPERTENSION DIAGNOSIS WHO ARE CONTROLLED (<140MMHG SYSTOLIC). WE HYPOTHESIZE THAT THE HTN-BASIC INTERVENTION WILL INCREASE CONTROL FROM 25% AT BASELINE TO 35%, AND THAT HTN-PLUS WILL FURTHER INCREASE CONTROL TO 40%. WE WILL CONDUCT AN EXTENSIVE MIXED-METHODS PROCESS EVALUATION. WE WILL ASSESS SCALABILITY AS OUR MAIN IMPLEMENTATION OUTCOME, AND WILL ALSO ASSESS ACCEPTABILITY, ADOPTION, AND IMPLEMENTATION CLIMATE. FINALLY, WE WILL EVALUATE THE ECONOMIC AND FINANCIAL SUSTAINABILITY OF THE INTEGRATED CARE STRATEGIES IN A COST-EFFECTIVENESS ANALYSIS FROM A SOCIETAL PERSPECTIVE THAT WILL INCLUDE HOUSEHOLD OUT-OF-POCKET EXPENDITURES. THE PRIMARY OUTCOME OF THIS AIM WILL BE INCREMENTAL COST PER BP- CONTROLLED PATIENT. THIS STUDY WILL PROVIDE MUCH NEEDED EVIDENCE TO SSA GOVERNMENT STAKEHOLDERS FOR A STRATEGY TO PRESERVE THE HEALTH GAINS OF HIV TREATMENT BY PREVENTING DEATH AND DISABILITY FROM CVD. IMPORTANTLY, IT WILL OFFER ECONOMIC EVIDENCE OF THE SCALABILITY, SUSTAINABILITY, AND EQUITY OF A MODEL OF HIV- HYPERTENSION MANAGEMENT INTEGRATION.

THIS AWARD FUNDS THE APPROVED 2024-2025 AMERICORPS NATIONAL DIRECT PROGRAM. NO MEMBER MAY ENROLL PRIOR TO THE APPROVED START DATE OF THE MEMBER ENROLLMENT PERIOD. YOUR 2024-2025 REGULATORY MATCH IS 24% AND YOUR BUDGETARY MATCH IS 33.79%.

PURPOSE: THE PURPOSE OF THIS AWARD IS TO BUILD THE CAPACITY OF HUD'S SPECIAL NEEDS ASSISTANCE PROGRAM CUSTOMER ORGANIZATIONS TO DEPLOY CONTINUUM OF CARE AND EMERGENCY SOLUTIONS GRANT PROGRAMS EFFECTIVELY AND IN COMPLIANCE WITH ASSOCIATED RULES AND REGULATIONS.; ACTIVITIES TO BE PERFORMED: HUD WILL IDENTIFY SPECIFIC TECHNICAL ASSISTANCE NEEDS TO BE ADDRESSED THROUGH A DEMAND-RESPONSE PROGRAM MODEL. THE RECIPIENT MAY RESPOND TO THOSE NEEDS THROUGH A RANGE OF ELIGIBLE ACTIVITIES: NEEDS ASSESSMENTS; DIRECT TECHNICAL ASSISTANCE AND CAPACITY BUILDING; DEVELOPMENT AND MAINTENANCE OF TOOLS AND PRODUCTS; SELF-DIRECTED AND GROUP LEARNING; KNOWLEDGE MANAGEMENT; DATA ANALYSIS, REPORTING, AND PERFORMANCE MEASUREMENT; ADMINISTRATION; AND COORDINATION. ; EXPECTED OUTCOMES: OUTCOMES ARE THE RESULTS OF TECHNICAL ASSISTANCE ACTIVITIES, INCLUDING BUT NOT LIMITED TO CHANGES IN MANAGEMENT OR OPERATION OF HUD-FUNDED PROGRAMS OR INITIATIVES. SPECIFIC OUTCOMES WILL VARY BASED ON THE NATURE OF THE ACTIVITIES CARRIED OUT. STANDARD OUTCOME CATEGORIES INCLUDE IMPROVED CAPACITY TO DESIGN PROGRAMS, POLICIES, AND STRATEGIES AS WELL AS TO DELIVER PROJECTS, PROGRAMS, OR SYSTEMS THAT ADDRESS COMMUNITY NEEDS AS DEFINED IN THE TECHNICAL ASSISTANCE (TA) SCOPE.; INTENDED BENEFICIARIES: SELECTED AWARD RECIPIENTS WILL BE DEPLOYED AS HUD DEEMS MOST NECESSARY ACROSS THE COUNTRY TO ASSIST ORGANIZATIONS RECEIVING HUD FUNDS TO IMPROVE PERFORMANCE AND MANAGEMENT OF HUD FUNDS. BENEFICIARIES WILL VARY BY ACTIVITY AND INCLUDE TECHNICAL ASSISTANCE CUSTOMERS OF HUD'S SPECIAL NEEDS ASSISTANCE PROGRAMS WHICH MANAGE AWARDS MADE UNDER A MCKINNEY-VENTO OR HEARTH ACT AUTHORIZATION.; SUBRECIPIENT ACTIVITIES: SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM-CHILD AND ADOLESCENT SUPPORT

SECTION 8 HOUSING CHOICE VOUCHERS

MENTORING - 2015 MULTI-STATE APPLICATION

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM-CHILD AND ADOLESCENT SUPPORT

MANUFACTURE OF AN INTRACEREBROVENTRICULAR ENZYME REPLACEMENT THERAPY FOR CLN1 BATTEN DISEASE - SUMMARY THE NEURONAL CEROID LIPOFUSCINOSES (NCLS) ARE A GROUP OF INCURABLE NEURODEGENERATIVE STORAGE DISORDERS PRIMARILY AFFECTING THE BRAIN AND THE RETINA OF CHILDREN AND YOUNG ADULTS, LEADING TO DEMENTIA, BLINDNESS, EPILEPSY, AND EARLY DEATH, WITH A PREVALENCE OF APPROXIMATELY 1.5 TO NINE PER MILLION POPULATION (1.3 TO 7 PER 100,000 LIVE BIRTHS). THE INFANTILE ONSET FORM CLN1 DISEASE IS CAUSED BY MUTATIONS IN THE CLN1/PPT1 GENE, WHICH CODES FOR THE LYSOSOMAL ENZYME PALMITOYL-PROTEIN THIOESTERASE-1 (PPT1) RESULTING IN A REDUCTION OR ABSENCE OF ENZYME ACTIVITY. CLN1 DISEASE USUALLY PRESENTS BETWEEN 6 AND 24 MONTHS OF AGE AND THERE ARE 2-3 CHILDREN WITH THIS FORM IDENTIFIED EACH YEAR AND CURRENTLY 24 KNOWN CHILDREN WITH CLN1 IN THE US AND 11 IN BRAZIL (WITH LIKELY MANY MORE UNDIAGNOSED). THERE ARE CURRENTLY NO TREATMENTS AVAILABLE OTHER THAN PALLIATIVE THERAPIES AND THE DISEASE IS FATAL. HUMAN RECOMBINANT PPT1 (RHPPT1) EXPRESSED IN CHO CELLS HAS BEEN PREVIOUSLY REPORTED TO MODIFY DISEASE PHENOTYPES FOLLOWING A SINGLE INTRATHECAL (IT) AND INTRAVENOUS (IV) ADMINISTRATION IN PPT1 DEFICIENT MICE (PPT1-/-). AFTER SUCCESSFUL COMPLETION OF OUR PHASE I SBIR IN WHICH WE MET OR EXCEEDED OUR MILESTONES IT, INTRACEREBROVENTRICULAR (ICV) AS WELL AS COMBINED ROUTES OF DELIVERY WERE COMPARED. WE DEMONSTRATED THAT MONTHLY ADMINISTRATION OF RHPPT1 VIA ICV PRODUCED STATISTICALLY SIGNIFICANT TREATMENT EFFECTS IN PPT1-/- MICE, SUCH AS RESCUE OF MORE THAN 60% PPT1 ENZYME ACTIVITY DECREASED SECONDARY ENZYME LEVELS, DECREASED THE LOSS OF NEURONS IN ALL REGIONS OF BRAIN AND SPINAL CORD AND IMPROVED GAIT AND ROTAROD RESULTS. THIS ALSO ILLUSTRATED THAT DELIVERY OF ENZYME VIA THIS ROUTE ALONE MAY BE SUFFICIENT RATHER THAN USING IN COMBINATION WITH IT DOSING. WE HAVE NOW DEVELOPED OUR OWN PPT1 CELL LINE USING CHO-DG44, THAT IS SCALABLE FOR GMP MANUFACTURE AND PERFORMED INITIAL PURIFICATION DEVELOPMENT STRATEGIES AND WE ARE DEVELOPING A DIAGNOSTIC TOOL FOR CLN1. THE CLN1 ERT DATA CLEARLY POINTS TO ICV DOSING AS IDEAL FOR FUTURE STUDIES, WHICH IS ALSO A PREFERRED ROUTE ACCORDING TO PHYSICIANS. COLLABORATIONS PHARMACEUTICALS, INC (CPI) NOW PROPOSES IN THIS PHASE II SBIR TO FILE A PREIND (WITH THE ASSISTANCE OF RTI INTERNATIONAL AND FORESIGHT BIOSCIENCES), PERFORM MANUFACTURING OF PPT1 (WITH THE ASSISTANCE OF GOODWIN BIOTECHNOLOGY, INC. AND CMC CONSULTANT DR. STEFAN PRONIUK), CONDUCT RAT AND DOG IND ENABLING TOXICOLOGY STUDIES (WITH THE ASSISTANCE OF CHARLES RIVER LABORATORIES) AND ULTIMATELY FILING AN IND (WITH THE ASSISTANCE OF RTI INTERNATIONAL AND FORESIGHT BIOSCIENCES). WE WILL HIRE THESE EXPERIENCED CONSULTANTS AND CLINICAL RESEARCH ORGANIZATIONS TO ASSIST US THROUGHOUT THE PROCESS AS THEY HAVE YEARS OF EXPERIENCE. THESE COLLABORATIONS WILL ENABLE US TO COST EFFECTIVELY AND MORE RAPIDLY TRANSLATE THIS POTENTIAL TREATMENT TO THE CLINIC THAT CAN POTENTIALLY SAVE THE LIVES OF CHILDREN LIVING WITH THIS DEVASTATING DISEASE. WE HAVE ALREADY OBTAINED AN ORPHAN DRUG DESIGNATION AND RARE PEDIATRIC DISEASE DESIGNATION FROM THE FDA FOR RHPPT1 AS A BIOLOGICAL PRODUCT FOR A “RARE PEDIATRIC DISEASE” WHICH OFFERS SEVERAL BENEFITS IN FUTURE UPON FDA APPROVAL, INCLUDING MARKETING EXCLUSIVITY FOR 7 YEARS AND THE POTENTIAL TO OBTAIN A RARE PEDIATRIC DISEASE VOUCHER AND THUS PROVIDE A RETURN ON INVESTMENT (CURRENT VALUE ~$100 M). WE ARE ENGAGED WITH CLN1 FAMILIES COMMUNICATING WITH THEM FREQUENTLY TO PROVIDE PROGRESS UPDATES AND WE ARE NOW WELL POSITIONED TO CONTINUE THE DEVELOPMENT OF THIS POTENTIAL TREATMENT FOR A DEVASTATING DISEASE. THERE IS AN IMPORTANT ROLE TO BRING TREATMENTS TO PATIENTS WITH ULTRA-RARE DISEASES AS ILLUSTRATED BY OTHER COMPANIES SUCH AS BIOMARIN AND ULTRAGENYX. OUR WORK ON DEVELOPING RHPPT1 AS AN ERT FOR CLN1 WOULD POSITION US WELL TO WORK ON FURTHER RARE DISEASES IN FUTURE AND GROW CPI.

SIMPLIFYING ENCODING OF BIOASSAYS TO ACCELERATE TRANSLATIONAL DRUG DISCOVERY

COMMUNITY COMPASS TECHNICAL ASSISTANCE AND CAPACITY BUILDING

COMMUNITY COMPASS TECHNICAL ASSISTANCE AND CAPACITY BUILDING

BIOCOMPUTATION ACROSS DISTRIBUTED PRIVATE DATASETS TO ENHANCE DRUG DISCOVERY

REPLICATION AND EVALUATION OF THE RISE-APS MODEL IN NEW CONTEXTS

VIOLENCE INTERVENTION AND TECHNICAL ASSISTANCE PROGRAM

THE MYSTERY OF MATTER: SEARCH FOR THE ELEMENTS (FULL-SCALE DEVELOPMENT)

USING MACHINE LEARNING AND IN VITRO METHODS TO ASSESS HUMAN METABOLISM OF ORGANOPHOSPHATES PESTICIDES AND CHEMICAL WARFARE AGENTS

CARES ACT RLF

HEALTH CENTER CONTROLLED NETWORKS

HOME INVESTMENT PARTNERSHIPS PROGRAM

LARGE SCALE 3-D PRINTED STEEL TOOLS FOR MOLDING LIGHTWEIGHT AUTOMOTIVE COMPOSITE COMPONENTS

COMMUNITY COMPASS TECHNICAL ASSISTANCE AND CAPACITY BUILDING

COMMUNITY COMPASS TECHNICAL ASSISTANCE AND CAPACITY BUILDING

THIS EDA INVESTMENT SUPPORTS THE GEORGIA AI MANUFACTURING (GA-AIM) COALITION, LED BY THE GEORGIA TECH RESEARCH CORPORATION, WITH INTEGRATING ARTIFICIAL INTELLIGENCE (AI) TECHNOLOGIES IN INDUSTRY BY ACCELERATING THE ADOPTION OF AI ACROSS THE STATE'S LEGACY INDUSTRIAL SECTORS. COALITION PROJECTS INCLUDE ESTABLISHING AN AI MANUFACTURING PILOT FACILITY AT GEORGIA TECH AND EXPAND JOB TRAINING OPPORTUNITIES IN AI FOR UNDERSERVED COMMUNITIES. THE GA-AIM COALITION AIMS TO SERVE AS A NATIONAL MODEL FOR HOW TO ACCELERATE THE TRANSITION TO AUTOMATION IN MANUFACTURING WHILE ENSURING THESE SYSTEMS COMPLEMENT RATHER THAN REPLACE EXISTING WORKERS. ONCE IMPLEMENTED, THE INVESTMENT WILL HELP DEVELOP AND STRENGTHEN REGIONAL INDUSTRY CLUSTERS - ALL WHILE EMBRACING ECONOMIC EQUITY, CREATING GOOD-PAYING JOBS, AND ENHANCING U.S. COMPETITIVENESS GLOBALLY.

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

MENTORING CHILDREN OF INCARCERATED PARENTS PARTNERSHIP (MCOIPP)

HEAL THE EARTH A SAN DIEGO COUNTY NONPROFIT AND AVOCADO FARM WILL IMPROVE AND GROW THE LONGTERM VIABILITY OF THE DOMESTIC ORGANIC AVOCADO MARKET BY COORDINATING A DIRECT TO CONSUMER VALUECHAIN AND LAUNCHING A COMPREHENSIVE REGIONAL MARKETING CAMPAIGN. THIS PROJECT WILL FACILITATE THE FLOW OF AVOCADOS INTO REGIONAL MARKETS BY LEVERAGING THE EXPERTISE OF VARIOUS PARTNERS. COLLABORATIVE EFFORTS WILL INCLUDE MARKETING AND OUTREACH TO BUYERS AND CONSUMERS PROMOTING OPPORTUNITIES TO SELL AND BUY USGROWN AVOCADOS AT A LOCAL FOOD HUB A FEASIBILITY STUDY AND RESULTING STRATEGIC PROMOTIONAL EFFORTS TAILORED TO THE NEEDS OF DOMESTIC ORGANIC AVOCADO GROWERS AND US CONSUMERS. HEAL THE EARTH WILL EXPAND STAFF CAPACITY BUILD AND MAINTAIN RELATIONSHIPS WITH CERTIFIED ORGANIC GROWERS ESTABLISH NEW AND EXPANDED MARKETS FOR ORGANIC AVOCADOS AND DEVELOP AND EXECUTE A MARKETING PLAN THAT DIFFERENTIATES THE ORGANIC USGROWN PRODUCT TO BOTH BUYERS AND END CONSUMERS. HEAL THE EARTH WILL BUILD RELATIONSHIPS BETWEEN ORGANIC AVOCADO PRODUCERS AND CONSUMERS CREATE ALTERNATIVE MARKET CHANNELS FOR ORGANIC AVOCADOS AND ANCILLARY ORGANIC FARM PRODUCTS INCREASE CONSUMER AWARENESS OF THE BENEFITS OF LOCALLYGROWN 7 CALIFORNIAPRODUCED AVOCADOS.

COMMUNITY COMPASS TECHNICAL ASSISTANCE AND CAPACITY BUILDING

HEALTHY TRANSITIONS: ROAD TO SUCCESS - PROJECT ABSTRACT SUMMARY PACT FOR FAMILIES COLLABORATIVE, A 30-YEAR, FIVE COUNTY CHILDREN’S MENTAL HEALTH AND SOCIAL SERVICES ORGANIZATION SERVING RURAL MN PROPOSES ROAD TO SUCCESS TO EXPAND SUPPORT TO YOUTH AGES 16-25 WHO HAVE EMERGING MENTAL HEALTH ISSUES, OR ARE AT RISK FOR SED/SMI DIAGNOSES, AND THEIR PARENTS BY UTILIZING THE TRANSITION TO INDEPENDENCE PLANNING (TIP) MODEL® AND COLLABORATING WITH KEY COMMUNITY, MENTAL HEALTH PROVIDERS AND POLICY MAKERS. ROAD TO SUCCESS WILL PROVIDE SERVICES TO 110 UNDUPLICATED YOUTH THROUGHOUT THE FIVE-YEAR PROJECT TERM. WITH MUCH TO SET UP IN THE FIRST YEAR, AN ESTIMATED 10 UNDUPLICATED YOUTH WILL BE SERVED IN YEAR ONE WITH 25 UNDUPLICATED YOUTH SERVED PER YEAR IN YEARS TWO THROUGH FIVE. PROJECT STAFF AND COLLABORATIVE PARTNERS WILL DEVELOP EARLY IDENTIFICATION PROTOCOL, PROVIDE EARLY INTERVENTION TO PREVENT EMERGING MENTAL HEALTH ISSUES FROM PROGRESSING TO SED/SMI DIAGNOSES. PROJECT STAFF WILL ASSIST YOUTH IN DEVELOPING GREATER SOCIAL AND EMOTIONAL SKILLS TO ENHANCE SELF-SUFFICIENCY AND INDEPENDENCE WHILE EMPHASIZING THE ROLE OF PARENTS/GUARDIANS IN GUIDING AND SUPPORTING THEIR YOUTH THROUGH THE TRANSITION TO ADULTHOOD. USING THE TIP MODEL®, VROON MIIWRAP WRAPAROUND, CHARTING A LIFECOURSETM, AND QPR MODELS OF INTERVENTION, THE PROJECT WILL EMPLOY IN-VIVO COACHING THROUGHOUT FIVE DOMAINS INCLUDING EMPLOYMENT, EDUCATION, HOUSING, LIFE SKILLS AND WELLNESS TO ENHANCE THE TARGET YOUTH AND YOUNG ADULT POPULATION’S COPING SKILLS AND EFFECTIVELY PREPARE THEM FOR TRANSITION. ENSURING THESE YOUTH RECEIVE WRAPAROUND SUPPORT, ROAD TO SUCCESS FOCUSES ON ENHANCING THE SKILLS AND CAPACITIES OF PARENTS TO SUPPORT THEIR YOUTH/YOUNG ADULTS THROUGH ONE-TO-ONE SUPPORT, EDUCATION, AND RESOURCE NAVIGATION. ROAD TO SUCCESS PROPOSES TO SERVE 300 PARENTS/GUARDIANS OVER THE FIVE YEARS THROUGH THE IMPLEMENTATION OF AN EDUCATIONAL SEMINAR SERIES, ONE TO ONE SUPPORT SESSIONS, COMMUNITY OUTREACH THROUGH CORRESPONDENCE AND SOCIAL MEDIA, AND BY FACILITATING PARENT NETWORKING GROUPS AND EDUCATIONAL OPPORTUNITIES. WE WILL TEACH OUR PARTICIPANTS WHERE RESOURCES CAN BE SHARED AMONGST PARENTS, PROVIDERS, STAFF, AND COMMUNITY MEMBERS. ADDITIONALLY, THIS PROPOSAL ESTABLISHES A MULTIAGENCY ADVISORY COUNCIL WITHIN SIX MONTHS TO OPERATE OVER THE FIVE-YEAR PERIOD AS A STEERING COMMITTEE FOCUSED ON COLLECTING DATA AND THEN PROPOSING STRATEGY TO ADDRESS SERVICE DELIVERY GAPS, FUNDING SHORTFALLS, AND INSTITUTIONALIZATION OF THE PROJECT’S MODEL INTO THE STRUCTURE OF THE COUNTIES’ SOCIAL SERVICES NETWORKS. PUTTING SUSTAINABILITY AT THE HEART OF THIS PROJECT REINFORCES PACT’S COMMITMENT TO CHANGING THE SYSTEM OF CARE AS IT EXISTS TODAY, THEREBY DEMONSTRATING TO RURAL MINNESOTA COMMUNITIES HOW THEY CAN SUPPORT THIS VULNERABLE POPULATION. ROAD TO SUCCESS REPRESENTS A SHIFT IN SERVICE DELIVERY AND WRAPAROUND SUPPORT THAT WILL DECREASE SED/SMI DIAGNOSES BY INCREASING THE RESILIENCE OF OUR TARGETED RURAL YOUTH, NURTURING MORE DURABLE PARENT-CHILD BONDS, AND SWAYING COMMUNITIES TO ADOPT SIMILAR SYSTEMS OF CARE. THIS WILL CULMINATE IN THEIR RECOGNITION OF THE VALUE OF INVESTING RESOURCES INTO ADDRESSING THIS PARTICULAR LIFE TRANSITION POINT TO ENHANCE THE SUPPORT NETWORK, TRANSFORM THE CURRENT SERVICE SYSTEM MODEL, AND SUSTAIN THESE SYSTEMS CHANGES INDEFINITELY.

DIALOGUE 250: TEACHER AND STUDENT ENGAGEMENT WITH TEXTS AND IDEAS REFLECTING 250 YEARS OF AMERICAN SELF-GOVERNMENT

HIV RESEARCH PROGRAM IN THAILAND AND CAMBODIA

TO IMPROVE TUBERCULOSIS (TB) EPIDEMIC RESPONSE IN MOZAMBIQUE’S HIGH BURDEN PROVINCES OF NORTHERN AND CENTRAL MOZAMBIQUE.

EXTRACTIVE INDUSTRIES GDA

RURAL CAPACITY BUILDING FOR COMMUNITY DEVELOPMENT AND AFFORDABLE HOUSING GRANTS

COMMUNITY COMPASS TECHNICAL ASSISTANCE AND CAPACITY BUILDING

COMMUNITY COMPASS TECHNICAL ASSISTANCE AND CAPACITY BUILDING

HEALTH CENTER CONTROLLED NETWORKS

COLLECTIVE OWNERSHIP GROW-YOUR-OWN EDUCATOR PIPELINE

JOURNEY TO INDEPENDENCE

OPTIMIZING PREVENTION OF PERITONEAL DIALYSIS-ASSOCIATED PERITONITIS: AN ANCILLARY STUDY OF THE PERITONEAL DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (PDOPPS)

TRANSITION TO TEACHING PROGRAM - TRANSITION TO TEACHING PROGRAM -- STATEWIDE

TALENT SEARCH PROGRAM

MANUFACTURING VALUABLE COAL-DERIVED PRODUCTS IN SOUTHERN APPALACHIA, NEW AWARD

MACHINE LEARNING APPROACHES TO PREDICT ACETYLCHOLINESTERASE INHIBITION AND MODEL APPLICATIONS - SUMMARY ORGANOPHOSPHORUS (OP) COMPOUNDS ARE ONE OF THE MOST COMMON CAUSES OF POISONING WORLDWIDE. THERE ARE NEARLY 3 MILLION POISONINGS PER YEAR RESULTING IN THREE HUNDRED THOUSAND DEATHS. OPS BIND TO ACETYLCHOLINESTERASE (ACHE), RENDERING THE ENZYME INCAPABLE OF HYDROLYZING ACETYLCHOLINE (ACH) IN THE CHOLINERGIC SYNAPSES AND NEUROMUSCULAR JUNCTIONS. SUBSEQUENT ACCUMULATION OF ACH LEADS TO OVERSTIMULATION OF THE AFFECTED NEURONS ACTING THROUGH MUSCARINIC AND NICOTINIC RECEPTORS. SOME OF THE ADVERSE EFFECTS OF PESTICIDES ON NON-TARGET ORGANISMS SUCH AS FISH, AMPHIBIANS AND HUMANS HAVE ALSO OCCURRED AS A RESULT OF BIOMAGNIFICATIONS OF THE TOXIC COMPOUNDS. SINCE ACHE IS A VERY WELL-STUDIED TARGET, THE LIKELIHOOD OF FINDING FURTHER NEW INHIBITORS AMONGST WELL-KNOWN DRUGS AND MOLECULES IS LIKELY UNLIKELY AND THEREFORE WE NEED TO LOOK FURTHER AFIELD AND DO THIS IN A MORE EFFICIENT MANNER. COMPUTATIONAL APPROACHES SUCH AS MACHINE LEARNING ARE AN APPROACH THAT CAN BE USED TO LEARN FROM DIVERSE LITERATURE TO ENABLE VIRTUAL SCREENING. FOLLOWING OUR PRELIMINARY WORK GENERATING BAYESIAN MODELS FOR HUMAN ACHE WE HAVE PERFORMED A HIGH THROUGHPUT SCREEN OF 2431 COMPOUNDS AND IDENTIFIED 66 COMPOUNDS THAT WERE “ACTIVE” AGAINST EEL ACHE. WE RECENTLY COMPLETED A PHASE I SBIR IN WHICH WE EXPANDED THE USE OF THESE MACHINE LEARNING MODELS TO CURATE ADDITIONAL ACHE DATA, BUILT AND VALIDATED ACHE MODELS WITH MANY ALGORITHMS IN PARALLEL AND USED THEM TO IDENTIFY ACHE INHIBITORS FROM VARIOUS SPECIES TO PREDICT OP INDUCED POISONING AND POSSIBLE THREATS TO THE ENVIRONMENT. IN ADDITION, WE HAVE RECENTLY CURATED FURTHER LITERATURE DATA AND GENERATED MODELS FOR THE CLOSELY RELATED ENZYME BCHE USING A CONTRASTIVE LEARNING ALGORITHM APPROACH TO SCORE A LIBRARY OF 5 MILLION MOLECULES FROM VARIOUS VENDORS IN ORDER TO SELECT MOLECULES FOR TESTING AND HAVE IDENTIFIED SEVERAL NOVEL SELECTIVE INHIBITORS. IN PHASE II WE WILL DEVELOP THE MEGAACHE SOFTWARE PRODUCT FURTHER FOR PREDICTION OF ACHE INHIBITION AND INCORPORATE UNCERTAINLY PREDICTION FEATURES AND NEW ALGORITHMS SUCH AS LARGE LANGUAGE MODELS. WE WILL ALSO USE THIS SOFTWARE TO DESIGN AND DEVELOP ACHE REACTIVATORS THAT COULD PROVIDE A NEW TREATMENT FOR OP PESTICIDE AND NERVE AGENT EXPOSURE. WE NOW PROPOSE THE FOLLOWING AIMS TO FURTHER DEVELOP AND VALIDATE THE MEGAACHE SOFTWARE AS A COMMERCIAL PRODUCT: AIM 1: MODELING UNCERTAINTY IN ACHE MODELS AIM 2: LARGE LANGUAGE MODELS FOR ACHE AND BCHE DATASETS AIM 3: DEVELOP NEW REACTIVATORS TO TREAT ACHE POISONING USING GENERATIVE DESIGN OUR ULTIMATE GOAL WILL BE TO PROVIDE SOFTWARE AND MODELS TO PREDICT ACHE INHIBITION WHICH WILL BE A COMMERCIAL PRODUCT. IN ADDITION WE WILL DEVELOP NEW MOLECULE INTELLECTUAL PROPERTY WHICH WE CAN THEN LICENSE TO A LARGER COMPANY. COMPUTATIONAL MODELS FOR ACHE THEREFORE HAVE BENEFICIAL DUAL-USE POTENTIAL BOTH FOR IDENTIFYING MOLECULES THAT COULD HAVE ENVIRONMENTAL OR HUMAN TOXICITY, WHILE ALTERNATIVELY SUCH MACHINE LEARNING MODELS COULD ALSO HELP US IDENTIFY MOLECULES WITH THERAPEUTIC UTILITY FOR ALZHEIMER’S DISEASE OR AS TREATMENTS FOR POISONING.

LITERACY FOR CIVIC LIFE: ENACTING A SCALABLE, EVIDENCE-BASED, CULTURALLY-RESPONSIVE APPROACH TO IMPROVING STUDENTS' CIVIC LITERACY SKILLS

CHESS CYBERSECURITY SHARED SERVICES - PHASE 1 PROJECT

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

ENABLING UNDERSERVED LANDOWNERS

RECIPIENT NAME: CALIFORNIA MOBILITY CENTERPROJECT TITLE:MOBILITY AND ADVANCED MANUFACTURING CAREER PATHWAYS PROGRAMFUNDING REQUEST: 2,000,000CONGRESSIONAL SPONSOR: CONGRESSMEMBER DORIS MATSUI, CA-006REQUESTED PERIOD OF PERFORMANCE: 24 MONTHSPROJECT LOCATION:WEST SACRAMENTO, SACRAMENTO COUNTY, PLACER COUNTY, EL DORADOCOUNTYPROJECT PURPOSE AND GOALS:CAREER EXPLORATION, JOB PLACEMENT, AND APPRENTICE REGISTRATIONACTIVITIES TO BE PERFORMED:COMMUNITY OUTREACH, CONDUCT AND FACILITATE JOB READINESS(TECHNICAL) TRAINING, SUPPORT JOB PLACEMENT, ENSURE JOB RETENTION,ENGAGE EMPLOYERS, INTEGRATE COMMUNITY ORGANIZATION, DEVELOPAND VALIDATE STANDARDS OF SKILLSETS NEEDED FOR SPECIFICOCCUPATIONS, FACILITATE EXPERIENTIAL LEARNING, PROVIDE CAREERCOACHING, DEVELOP APPRENTICESHIP PROGRAMSEXPECTED OUTCOMES: 375 TRAINED, 300 (188) EMPLOYED, 112 REGISTERED APPRENTICESINTENDED BENEFICIARIES:LOW-INCOME, UNDERREPRESENTED, AND HIGH-BARRIER COMMUNITIESSUBRECIPIENT ACTIVITIES:SYNBYO - PROJECT MANAGEMENT, PROGRAM DEVELOPMENTCAL EMPOWERED - SUCCESS TEAM DEVELOPMENT MANAGEMENTASIAN RESOURCES, GREATER SACRAMENTO URBAN LEAGUE, LA FAMILIA - MOBILE LAB OUTREACH EVENT HOSTINTERNAL RESCUE COMMITTEE, COMMUNITY RESOURCE PROJECT - TRAINING HOSTGREENTECH, NEXT MOVE, SAINT JOHN'S, WOMEN'S EMPOWERMENT - PARTICIPANT RECRUITMENT AND SCREENINGRENEWABLE GATEWAY - CAREER EXPLORATION ACTIVITIESSACRAMENTO VALLEY MANUFACTURING ALLIANCE - APPRENTICESHIP PROGRAM DEVELOPMENT AND MANAGEMENTCHARLES A JONES CAREER AND EDUCATION CENTER - TECHNICAL TRAINING PROGRAM DEVELOPMENT

MENTORING 2016 MULTI-STATE APPLICATION

THROUGH THE MENTORING+ (M+) PROJECT, YOUTH COLLABORATORY WILL ADDRESS THE INDIVIDUAL, SOCIAL, AND ENVIRONMENTAL RISK FACTORS THAT PUT YOUTH AT INCREASED RISK FOR DELINQUENCY OR VICTIMIZATION AND/OR ARE INVOLVEMENT IN THE JUVENILE JUSTICE SYSTEM (JJS). YOUTH COLLABORATORY WILL PARTNER WITH 13 COMPETITIVELY SELECTED M+ CHAPTERS (SUBRECIPIENTS) OFFERING SERVICES THROUGH 193 SITES IN 12 STATES (CA, CT, IA, MI, MN, NM, NY, NC, OK, SC, TX, AND WY. M+ IMPROVES POSITIVE OUTCOMES FOR YOUTH THROUGH QUALITY MENTORING SERVICES THAT INCREASE YOUTH'S RESILIENCY TO INDIVIDUAL, SOCIAL, AND ENVIRONMENTAL RISK FACTORS THAT CAN LEAD TO JUVENILE DELINQUENCY OR VICTIMIZATION. THE INTENDED BENEFICIARIES ARE YOUTH AGES 6-17 YEARS (PRIORITIZING YOUTH AGES 13-17) WHO ARE HISTORICALLY MARGINALIZED AND AT RISK OR HIGH-RISK FOR DELINQUENCY OR VICTIMIZATION AND/OR ARE INVOLVED IN JJS. IN ADDITION, THESE YOUTH ARE IMPACTED BY BULLYING, HOMELESSNESS, PARENTAL INCARCERATION, ACTIVE MILITARY DUTY, OPIOIDS AND OTHER DRUGS, HUMAN TRAFFICKING AND EXPLOITATION, THE CHILD WELFARE SYSTEM, IMPACT OF VICTIMIZATION, AND LIVING IN RURAL COMMUNITIES. OBJECTIVES OF THIS PROJECT INCLUDE EXPANDING DIRECT ONE-ON-ONE & GROUP MENTORING SERVICES TO 1,900 YOUTH; PROVIDING QUALITY PRE-MATCH AND ON-GOING TRAINING AND DEVELOPMENT TO 1,900 MENTORS THAT REFLECT THE YOUTH THEY SERVE; AND 3) DESIGNING ENHANCEMENT THAT STRENGTHEN PROTECTIVE FACTORS IN YOUTH AND THEIR FAMILIES THROUGH CULTURALLY APPROPRIATE RESEARCH AND EVIDENCE-BASED MENTORING APPROACHES, STRATEGIES, AND ENGAGEMENT. ACTIVITIES INCLUDE INCORPORATING ENHANCEMENTS INTO THE SIX CORE AREAS OF MENTORING PRACTICE, PROVIDING ONGOING ONE-ON-ONE AND GROUP COMMUNITY-BASED MENTORING, PROVIDING ONGOING COACHING FOR STAFF ON ENHANCEMENTS, OFFER ENHANCED DEVELOPMENT OPPORTUNITIES TO MENTORS, PROVIDE ENHANCED MONITORING AND SUPPORTS THROUGH STRUCTURED ACTIVITIES, AND IMPROVE ENGAGEMENT WITH PARENTS/CAREGIVERS THROUGH MONTHLY COMMUNICATION/QUARTERLY ACTIVITIES AND COMMUNITY RESOURCES.

OJJDP FY 20 MENTORING OPPORTUNITIES FOR YOUTH INITIATIVE

EMERALD CITIES COLLABORATIVE, EMERALD CONNECTIONS: COMMUNITY CENTERED WEATHERIZATION + HEALTH THE OVERARCHING GOAL OF THIS PROJECT IS TO DELIVER 120 DEEP ENERGY RETROFITS TO JUSTICE40 COMMUNITIES BY EMPLOYING DEEP COMMUNITY ENGAGEMENT STRATEGIES IN WA AND MA. WE DEFINE DEEP ENERGY RETROFITS WITHIN THE CONTEXT OF THIS PROJECT TO INCLUDE CLIMATE AND HEALTH MITIGATION STRATEGIES AS WELL. WE KNOW THAT SOME OF THE LARGEST BARRIERS TO IMPLEMENTING WEATHERIZATION INCLUDE HEALTH AND SAFETY BARRIERS. BY MITIGATING THESE BARRIERS WE CAN IMPLEMENT WAP PROJECTS THEREBY REDUCING ENERGY BURDEN AND IMPROVING CLIMATE RESILIENCY.

LOST WAGES SUPPORT FOR LIVING ORGAN DONORS DEMONSTRATION PROJECT

ONE CPD TA SUPP HSNG

RESIDENCY TRAINING IN PRIMARY CARE

TALENT SEARCH PROGRAM

HIGH SCHOOL EQUIVALENCY PROGRAM

CAROL M. WHITE PHYSICAL EDUCATION PROGRAM

JOURNEY TO INDEPENDENCE - PROJECT ABSTRACT SUMMARY PACT FOR FAMILIES COLLABORATIVE (PACT), WAS ESTABLISHED IN 1993 AS A CHILDREN'S MENTAL HEALTH AND FAMILY SERVICES ORGANIZATION SERVING FIVE RURAL MINNESOTA COUNTIES. PACT PROPOSES JOURNEY TO INDEPENDENCE (JTI) TO SUPPORT YOUTH AGES 14-21 WHO HAVE EMERGING MENTAL HEALTH ISSUES, OR ARE AT RISK FOR SED/SMI DIAGNOSES, WHILE ALSO OFFERING SUPPORT FOR THEIR PARENTS. PACT WILL EMPLOY THE TRANSITION TO INDEPENDENCE PLANNING (TIP) MODEL® AND ENGAGE IN COLLABORATION WITH ESSENTIAL COMMUNITY RESOURCES, MENTAL HEALTH PROVIDERS, AND POLICYMAKERS. JTI WILL PROVIDE SERVICES TO 108 UNDUPLICATED YOUTH THROUGHOUT THE FOUR-YEAR PROJECT TERM. WITH OUR EXISTING JTI PROGRAM OPERATING AT FULL CAPACITY, THIS PROPOSAL WILL EXTEND OUR SERVICES TO INCLUDE YOUTH AGED 14 AND 15, WHILE MAINTAINING SUPPORT FOR THOSE AGED 16 TO 21. WE WILL SERVE 27 UNDUPLICATED YOUTH IN THE FIRST YEAR AND MAINTAIN THIS NUMBER ANNUALLY FOR YEARS TWO THROUGH FOUR. PROJECT STAFF AND COLLABORATIVE PARTNERS WILL DEVELOP EARLY IDENTIFICATION PROTOCOL, PROVIDING EARLY INTERVENTION TO HELP PREVENT EMERGING MENTAL HEALTH ISSUES FROM PROGRESSING TO SED/SMI DIAGNOSES. PROJECT STAFF WILL ASSIST YOUTH IN DEVELOPING GREATER SOCIAL AND EMOTIONAL SKILLS TO ENHANCE SELF-SUFFICIENCY AND INDEPENDENCE WHILE EMPHASIZING THE ROLE OF PARENTS/GUARDIANS IN GUIDING AND SUPPORTING THEIR YOUTH THROUGH THE TRANSITION TO ADULTHOOD. USING THE TIP MODEL® AND VROON MIIWRAP ® WRAPAROUND, THE PROJECT WILL UTILIZE IN-PERSON COACHING THROUGHOUT FIVE DOMAINS, INCLUDING EMPLOYMENT, EDUCATION, HOUSING, LIFE SKILLS, AND WELLNESS TO ENHANCE THE YOUTH AND YOUNG ADULT PARTICIPANTS COPING SKILLS AND EFFECTIVELY PREPARE THEM FOR TRANSITION. ENSURING THESE YOUTH RECEIVE WRAPAROUND SUPPORT, JTI FOCUSES ON ENHANCING THE SKILLS AND CAPACITIES OF PARENTS TO SUPPORT THEIR YOUTH/YOUNG ADULTS THROUGH ONE-TO-ONE SUPPORT, EDUCATION, AND RESOURCE NAVIGATION. JTI PROPOSES TO SERVE 300 PARENTS/GUARDIANS OVER THE FOUR YEARS THROUGH THE IMPLEMENTATION OF AN EDUCATIONAL SEMINAR SERIES, ONE TO ONE SUPPORT SESSIONS, COMMUNITY OUTREACH THROUGH CORRESPONDENCE AND SOCIAL MEDIA, AND BY FACILITATING PARENT NETWORKING GROUPS AND EDUCATIONAL OPPORTUNITIES. WE WILL HELP OUR PARTICIPANTS LEARN ABOUT MENTAL HEALTH AND COMMUNITY RESOURCES THAT CAN BE SHARED TO SUPPORT PARENTS, LEARN ABOUT PROVIDERS AND STAFF INVOLVED WITH THE PROJECT. THIS PROPOSAL WILL LEVERAGE PACT’S FIVE COUNTY LOCAL CHILDREN’S MENTAL HEALTH ADVISORY COUNCIL (LAC) TO ESTABLISH A SUBCOMMITTEE THAT WILL SERVE AS THE JTI ADVISORY COMMITTEE. THIS COMMITTEE WILL BE DEDICATED TO COLLECTING DATA AND PROPOSING STRATEGIES AIMED AT ADDRESSING SERVICE DELIVERY GAPS AND FUNDING SHORTFALLS, WITH THE OVERARCHING GOAL OF ENHANCING THE SYSTEM OF CARE ACROSS THE FIVE-COUNTY SERVICE REGION. PUTTING SUSTAINABILITY AT THE HEART OF THIS PROJECT REINFORCES PACT’S COMMITMENT TO CHANGING THE SYSTEM OF CARE AS IT EXISTS TODAY, THEREBY DEMONSTRATING TO RURAL MINNESOTA COMMUNITIES HOW THEY CAN SUPPORT THIS VULNERABLE POPULATION. JTI REPRESENTS AN APPROACH TO SERVICE DELIVERY AND WRAPAROUND SUPPORT AIMED AT REDUCING SED/SMI DIAGNOSES AMONG RURAL YOUTH. BY INCREASING RESILIENCE, STRENGTHENING PARENT-CHILD BONDS, AND ADVOCATING FOR COMMUNITY INVOLVEMENT, WE AIM TO TRANSFORM THE CURRENT SERVICE SYSTEM MODEL. THIS INITIATIVE SEEKS TO DEMONSTRATE THE VALUE OF INVESTING RESOURCES IN ADDRESSING CRUCIAL LIFE TRANSITIONS, ULTIMATELY SUSTAINING POSITIVE SYSTEM CHANGES INDEFINITELY.

CRIMINAL JUSTICE SECTOR - ASSESSMENT, DESIGN AND IMPLEMENTATION OF PROJECTS IN THREE COUNTRIES IN AFRICA

THE GOALS OF THESE FOUR-YEAR R&D ACTIVITIES ARE TO APPLY FINDINGS FROM THE FIRST ROUND OF SAS RESEARCH TO ENABLE DEVELOPMENT PARTNERSHIPS TO BECOME MORE LOCALLY LED. THIS INITIATIVE WILL FOCUS ON HOW TO MAKE TRANSITIONS TO LOCAL LEADERSHIP MORE EFFECTIVE AND SUSTAINABLE FOR THE LOCAL ACTORS, AND ASSISTING NETWORKS OF DEVELOPMENT ACTORS (USAID, LOCAL ORGANIZATIONS, AND INTERNATIONAL PARTNERS) TO BECOME MORE RESPONSIVE TO THE COMMUNITIES IN WHICH THEY WORK.

TRUST FRAMEWORK DEVELOPMENT GUIDANCE FOR SMALL AND MEDIUM-SIZED BUSINESSES AND FINANCIAL SECTORS PILOTS

2017 MENTORING FOR CHILD VICTIMS OF CSE/DST TRAINING AND TECHNICAL ASSISTANCE INITIATIVE

MEGATRANS ? HUMAN TRANSPORTER MACHINE LEARNING MODELS - SUMMARY BEING ABLE TO PREDICT INTERACTIONS WITH IMPORTANT HUMAN TRANSPORTERS WOULD BE OF VALUE TO NEW DRUG DESIGN TO AVOID COMPOUNDS THAT INTERACT WITH THEM AND CAUSE UNDESIRABLE SIDE EFFECTS. CONVERSELY, SOME DRUG TRANSPORTERS CAN BE USED FOR TARGETING MOLECULES TO SPECIFIC ORGANS AND THIS MAY HAVE CONSIDERABLE UTILITY. UNDERSTANDING THE INTERACTIONS OF NOVEL DRUGS, NATURAL PRODUCTS AND ENVIRONMENTAL TOXICANTS AND THEIR INTERACTIONS WITH AN ARRAY OF SUCH TRANSPORTERS IS, THEREFORE, IMPORTANT FOR SEVERAL INDUSTRIES, AS WELL AS FROM A REGULATORY PERSPECTIVE (E.G. FDA, EPA AND EMA). BEING ABLE TO PREDICT SUCH INTERACTIONS IN A FAST AND RELIABLE MANNER EFFECTIVELY REQUIRES USING COMPUTATIONAL APPROACHES AND LEARNING FROM IN VITRO DATA, THE LATTER A RESOURCE THAT IS RAPIDLY GROWING. OVER THE PAST 20 YEARS, WE HAVE BEEN AT THE FOREFRONT OF APPLYING DIFFERENT MACHINE LEARNING APPROACHES TO MODELING DRUG TRANSPORTERS AND, IN MANY CASES, DEVELOPING DATASETS FOR TRANSPORTERS FOR WHICH THERE WAS SCANT AVAILABLE DATA. WE NOW PROPOSE DOING THIS FOR SEVERAL TRANSPORTERS THAT MAY BE IMPORTANT FOR DRUG DISCOVERY. IN PHASE I WE FOCUSED ON OATP1B1 (SLCO1B1), WHICH IS AN UPTAKE TRANSPORTER LARGELY RESTRICTED TO THE SINUSOIDAL ASPECT OF HEPATOCYTES WHERE IT MEDIATES TRANSPORT OF A VARIETY OF STRUCTURALLY UNRELATED COMPOUNDS, INCLUDING MEMBERS OF SEVERAL CLINICALLY IMPORTANT DRUG FAMILIES (INCL. STATINS, SARTANS AND ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITORS). WE TESTED 476 DRUGS AGAINST ONE SUBSTRATE IN VITRO. WE THEN CURATED THESE DATA AND BUILT MACHINE LEARNING MODELS USING MULTIPLE MACHINE LEARNING METHODS AS WELL AS MODEL EVALUATION METRICS. THIS ENABLED US TO DEVELOP MODELS FOR INTEGRATION IN A WEB-BASED SOFTWARE TOOL CALLED MEGATRANS® THAT ENABLES THE USER TO INPUT THEIR OWN COMPOUND STRUCTURES AND GENERATE PREDICTIONS FOR INTERACTIONS WITH TRANSPORTER/S OF INTEREST, AS WELL AS VISUALIZE THE SIMILARITY TO THE TRAINING SET OF EACH MODEL USING SEVERAL DIFFERENT VISUALIZATION METHODS. IN ADDITION, DURING PHASE I WE ALSO PERFORMED PRELIMINARY DATA CURATION, MODEL BUILDING AND VALIDATION FOR TWO EQUILIBRATIVE NUCLEOSIDE TRANSPORTERS (ENTS), ENT1 AND ENT2, THAT ARE PRESENT AT THE BLOOD TESTES BARRIER (BTB), WHERE THEY CAN FACILITATE DRUG DISPOSITION (E.G. FOR ANTIVIRALS, THEREBY POTENTIALLY ELIMINATING A SANCTUARY SITE FOR VIRUSES DETECTABLE IN SEMEN). WE GENERATED BAYESIAN AND PHARMACOPHORE MODELS AND USED THESE TO PREDICT NUMEROUS COMPOUNDS THAT WERE THEN TESTED IN VITRO AGAINST ENTS. WE USED THESE ENT MODELS TO PREDICT (I) THE ANTIVIRALS USED IN TREATING COVID-19, REMDESIVIR AND MOLNUPIRAVIR, INHIBIT ENT ACTIVITY, AND THAT (II) REMDESIVIR IS AN ENT SUBSTRATE, AS WELL AS VALIDATING THESE PREDICTIONS. IN PHASE II WE PLAN ON BUILDING ON THE FOUNDATION OF PHASE I AND PROPOSE GREATLY EXPANDING THE ENT1 AND ENT2 MODELS THROUGH IN VITRO TESTING (AT THE UNIVERSITY OF ARIZONA) OF >2000 APPROVED DRUGS, NATURAL PRODUCTS, AND ENVIRONMENTAL TOXICANTS AS INHIBITORS OF ENT TRANSPORT. WE WILL USE THESE DATA TO BUILD AND VALIDATE MACHINE LEARNING MODELS USING SEVERAL ALGORITHMS, AT COLLABORATIONS PHARMACEUTICALS, INC. WE WILL ALSO TEST THESE MODELS USING EXTERNAL VALIDATION WITH ADDITIONAL MOLECULES FROM VENDOR LIBRARIES AND DRUG COLLECTIONS THAT ARE NOT IN THE MODEL. IN THIS PROCESS WE WILL ALSO BUILD OUT THE CAPABILITIES OF MEGATRANSÒ TO USE 3D PHARMACOPHORE DESCRIPTORS TO INCORPORATE MOLECULAR SHAPE FEATURES AND ALLOW 3D SEARCHES. THE RETURN ON INVESTMENT OF SUCH A COMMERCIAL TOOL WOULD BE THAT IT COULD ASSIST IN THE DESIGN AND SELECTION OF MORE FAVORABLE COMPOUNDS BY AVOIDING TRANSPORTERS OF INTEREST (OR, CONVERSELY, ALLOW THE TARGETING OF SPECIFIC TRANSPORTERS TO INCREASE UPTAKE INTO ORGANS). IT COULD ALSO IDENTIFY COMPOUNDS THAT ARE ALREADY APPROVED THAT MIGHT PRESENT A DRUG-INTERACTION RISK. PREDICTING SUCH BEHAVIOR SEEN IN VIVO IS IDEAL AND WILL LEAD TO THE PRIORITIZATION OF COMPOUNDS TO TEST

2014 MENTORING FOR CHILD VICTIMS OF CSE/DST TRAINING AND TECHNICAL ASSISTANCE INITIATIVE

MEGATOX FOR ANALYZING AND VISUALIZING DATA ACROSS DIFFERENT SCREENING SYSTEMS - PROJECT SUMMARY COMPUTATIONAL TOXICOLOGY AIMS TO USE RULES, MODELS AND ALGORITHMS BASED ON PRIOR DATA FOR SPECIFIC ENDPOINTS, TO ENABLE THE PREDICTION OF WHETHER A NEW MOLECULE WILL POSSESS SIMILAR LIABILITIES OR NOT. IN SOME CASES, THE COMPUTATIONAL MODELS ARE DERIVED FROM DISCRETE MOLECULAR ENDPOINTS (E.G. ESTROGEN RECEPTOR AGONISM) WHILE IN OTHERS THEY ARE QUITE BROAD IN SCOPE (E.G. DRUG INDUCED LIVER INJURY, DILI). CONSIDERABLE PROGRESS HAS BEEN MADE IN COMPUTATIONAL TOXICOLOGY IN A DECADE BOTH IN MODEL DEVELOPMENT AND AVAILABILITY SUCH THAT THE LATEST GENERATION OF LARGER SCALE MACHINE LEARNING (ML) MODELS WILL FURTHER FOCUS IN VITRO AND IN VIVO TESTING ON VERIFICATION OF SELECT PREDICTIONS. PHARMACEUTICAL, CONSUMER PRODUCTS, AGROCHEMICAL AND OTHER CHEMISTRY FOCUSED COMPANIES POSSESS STRUCTURE-ACTIVITY DATA GENERATED OVER MANY DECADES OF SCREENING THAT IS NOT IN THE PUBLIC DOMAIN, AND THIS DATA IS PRIMARILY ONLY ACCESSIBLE TO THE CHEMINFORMATICS EXPERTS IN EACH COMPANY. OUTSIDE OF THESE COMPANIES SMALL PHARMACEUTICAL, BIOTECH COMPANIES AND ACADEMICS MUST RELY ON DATA FROM PUBLIC DATABASES, COMMERCIAL DATABASES AND THEIR OWN DATA. INTEGRATING SUCH DATA FROM DIVERSE SOURCES AND PROCESSING WITH ALGORITHMS TO BUILD MACHINE LEARNING (ML) MODELS THAT CAN HELP TO ENABLE PREDICTIONS FOR NEW COMPOUNDS IS A VAST UNDERTAKING. OVER PHASE I OF THIS PROJECT TO DEVELOP THE PROTOTYPE FOR MEGATOXÒ, WE CURATED TOXICITY DATASETS THEN GENERATED AND TESTED WELL OVER 200 ML MODELS INITIALLY FOCUSED ON THE BAYESIAN APPROACH. WE HAVE ALSO DEVELOPED APPROACHES TO UNDERSTAND TRAINING AND TEST SET APPLICABILITY AND ULTIMATELY PERFORMED PROSPECTIVE PREDICTIONS AGAINST SEVERAL TOXICITY TARGETS. HAVING COMPLETED THESE AIMS, WE ALSO COLLABORATED WITH NUMEROUS ACADEMIC LABORATORIES AND PERFORMED FEE-FOR-SERVICE WORK WITH FIVE COMMERCIAL COMPANIES. WE CURRENTLY HAVE SEVERAL PHARMACEUTICAL, AGROCHEMICAL AND CONSUMER PRODUCT COMPANIES EVALUATING OUR COMPUTATIONAL TOXICITY MODELS PRIOR TO LICENSING. THESE DISCUSSIONS WITH POTENTIAL CUSTOMERS HAVE INFLUENCED THIS PHASE II PROPOSAL TO INCLUDE THE FOLLOWING AIMS: 1. COMPARE AND INTEGRATE NOVEL GRAPH-BASED MODELS SUCH AS GRAPHSAGE VERSUS OUR SUITE OF 15 DIFFERENT ML REGRESSION AND CLASSIFICATION ALGORITHMS FOR MODELING TOXICOLOGY DATASETS SUCH AS THOSE GENERATED IN PHASE I. 2. INTEGRATE READ ACROSS AND ADVERSE OUTCOME PATHWAY METHODS WITH OUR COMPUTATIONAL MODELS FOR DILI AND OTHER TOXICITY MODELS AS NEEDED. 3. GENERATE VALIDATED ML MODELS FROM IN VIVO DATA FOR NON-MAMMALIAN SPECIES (INITIALLY USING ZEBRAFISH) WHICH WILL ENABLE IN VITRO AND IN VIVO CORRELATIONS AND CAN BE VALIDATED RELATIVELY COST EFFECTIVELY. IN THIS PROPOSAL OVER 2 YEARS WE EXPECT TO DEVELOP MODELS WITH 15 DIFFERENT ALGORITHMS FOR AT LEAST 100 IN VITRO AND IN VIVO DATASETS, LEADING TO > 1500 TOXICITY ML MODELS. WE ARE NOT AWARE OF ANY OTHER COMPANY PURSUING SUCH AN APPROACH TO BOTH GENERATE NEW HIGH VALUE DATASETS OR MODELS, PERFORMING TESTING OF THEIR OWN MODELS AND CREATING A WIDE ARRAY OF TOXICITY ML MODELS. MEGATOXÒ WILL BE A PRODUCT AVAILABLE FOR LICENSING BY PHARMACEUTICAL, CONSUMER PRODUCT, AGROCHEMICAL AND REGULATORY GROUPS AS WELL AS USED IN FEE-FOR-SERVICE CONSULTING.

A ROBUST, SECURE FRAMEWORK TO EFFORTLESSLY BIND DISTRIBUTED DATABASES AND ANALYSIS TOOLS INTO TIGHTLY INTEGRATED TRANSLATIONAL DRUG DISCOVERY COMPUTATIONAL PLATFORMS - PROJECT SUMMARY COLLABORATIVE DRUG DISCOVERY, INC. (CDD) PROPOSES TO DEVELOP CLOUD WORKSPACES FOR DRUG DISCOVERY – A NOVEL INFORMATICS FRAMEWORK THAT WILL ENABLE SCIENTISTS ENGAGED IN DRUG DISCOVERY AND TRANSLATION TO EFFORT- LESSLY, ROBUSTLY, AND SECURELY INTEGRATE DISPARATE DATABASES AND COMPUTATIONAL TOOLS DISTRIBUTED ACROSS MULTIPLE SYSTEMS AND VENDORS INTO HIGHLY-EFFICIENT, CUSTOM-TAILORED COMPUTATIONAL WORKFLOWS. OUR INNOVATIVE TECHNOL- OGY WILL SOLVE A CRITICAL PROBLEM THAT HINDERS DRUG DISCOVERY AND TRANSLATION EFFORTS: SCIENTISTS IN THIS FIELD TYPI- CALLY NEED TO COMBINE CHEMICAL AND BIOLOGICAL DATA FROM SEVERAL SOURCES, RUN THEM THROUGH MULTIPLE SOFTWARE PACKAGES THAT SPECIALIZE IN DIFFERENT TYPES OF ANALYSES AND VISUALIZATION, THEN IDEALLY STORE THE RESULTS OF THE ANALYSES TOGETHER WITH THEIR UNDERLYING EXPERIMENTAL DATA. TODAY, THIS TYPE OF INTEGRATION IS DIFFICULT AND EXPENSIVE TO ACCOMPLISH AND TYPICALLY FRAGILE, CREATING A LARGE BARRIER TO (I) EXPLOITING THE RAPIDLY INCREASING NUMBER OF HIGH-QUALITY PUBLIC-ACCESS DATA REPOSITORIES AND (II) EVALUATING PROMISING NEW ANALYTICAL TOOLS AND STRATEGIES. MONOLITHIC PLATFORMS OFFER TO SOLVE THIS PROBLEM BY BRINGING EVERYTHING TOGETHER UNDER ONE ROOF, BUT THEY ARE EXTREMELY EXPENSIVE AND THEY LIMIT FLEXIBILITY: NO SINGLE PLATFORM CAN OFFER EVERY CAPABILITY. THE ALTER- NATIVE APPROACH – STRINGING TOGETHER DISCRETE RESOURCES – EVOLVED DURING THE ERA OF DESKTOP COMPUTING AND DOES NOT TRANSLATE WELL TO MODERN CLOUD-BASED WORKFLOWS AND IN PARTICULAR TO THE CHALLENGES OF PERFORMING COMPUTATIONALLY INTENSIVE OPERATIONS THAT REQUIRE COMBINING LARGE DATASETS DISTRIBUTED ACROSS REMOTE SYSTEMS. CLOUD WORKSPACES (CW) AIMS TO COMBINE THE STRENGTHS AND AVOID THE WEAKNESSES OF THESE TWO EXTREMES. CW WILL IN ESSENCE ALLOW USERS TO EASILY CREATE THEIR OWN INDIVIDUALIZED CLOUD-HOSTED SOLUTIONS TAILORED TO THEIR UNIQUE REQUIREMENTS AND WORKFLOWS. OUR APPROACH OFFERS THE PERFORMANCE, ROBUSTNESS, AND EASE OF USE OF A MONOLITHIC SOFTWARE SOLUTION, BUT WITHOUT THE ASSOCIATED INFLEXIBILITY AND VENDOR LOCK IN. IT OFFERS THE FLEXIBILITY AND OPENNESS OF COMBINING DISCRETE RESOURCES, BUT WITHOUT THE ASSOCIATED INTEGRATION CHALLENGES AND FRAGILITY, AND IT ADVANCES THE PIPELINING APPROACH TO EMBRACE CLOUD-BASED MODELS AND TO ENCOMPASS DISTRIBUTED DATA RESOURCES WITHOUT COMPROMISING PERFORMANCE OR SECURITY. IN PHASE 1 WE PROVED THAT WE COULD ROBUSTLY AND EFFICIENTLY SYNCHRONIZE BIOLOGICAL AND CHEMICAL DATA (TRANSFERRING ONLY NEW OR MODIFIED DATA WHILE RETAINING CORRECT ASSOCIATION OF CHEMICAL IDENTIFIERS) BETWEEN THE CW CONTAINER ENVIRONMENT AND REMOTE DATABASES, WHICH WAS A CHALLENGING BUT ESSENTIAL PREREQUISITE FOR OUR CONCEPT. IN PHASE 2 WE WILL COMPLETE DEVELOPMENT OF CW AND DEMONSTRATE ITS EFFECTIVENESS WITH MULTIPLE REAL-WORLD APPLICATIONS TOGETHER WITH SOFTWARE APPLICATION PARTNERS AND BETA CUSTOMER END USERS. THE MARKET FOR THE TECHNOLOGY RANGES FROM ACADEMICS TO SMALL AND MEDIUM SIZE COMPANIES TO THE LARGE PHARMACEUTICAL FIRMS.

SEE NOTICE OF AWARD, ATTACHMENT 1 - TERMS AND CONDITIONS, ATTACHMENT D-STATEMENT OF WORK, ABSTRACT.

SYMPTOMS OF LOWER URINARY TRACT DYSFUNCTION RESEARCH NETWORK (LURN)DATA COORDINAT

TEACHING AMERICAN HISTORY GRANTS

TAVAANA 2.0

TALENT SEARCH PROGRAM

COMMUNITY COMPASS TECHNICAL ASSISTANCE AND CAPACITY BUILDING

PURPOSE: THE PURPOSE OF THIS AWARD IS TO BUILD THE CAPACITY OF HUD'S TECHNICAL ASSISTANCE CUSTOMER ORGANIZATIONS TO DEPLOY HUD-FUNDED PROGRAMS AND INITIATIVES EFFECTIVELY AND IN COMPLIANCE WITH ASSOCIATED RULES AND REGULATIONS.; ACTIVITIES TO BE PERFORMED: HUD WILL IDENTIFY SPECIFIC TECHNICAL ASSISTANCE NEEDS TO BE ADDRESSED THROUGH A DEMAND-RESPONSE PROGRAM MODEL. THE RECIPIENT MAY RESPOND TO THOSE NEEDS THROUGH A RANGE OF ELIGIBLE ACTIVITIES: NEEDS ASSESSMENTS; DIRECT TECHNICAL ASSISTANCE AND CAPACITY BUILDING; DEVELOPMENT AND MAINTENANCE OF TOOLS AND PRODUCTS; SELF-DIRECTED AND GROUP LEARNING; KNOWLEDGE MANAGEMENT; DATA ANALYSIS, REPORTING, AND PERFORMANCE MEASUREMENT; ADMINISTRATION; AND COORDINATION.; EXPECTED OUTCOMES: OUTCOMES ARE THE RESULTS OF TECHNICAL ASSISTANCE ACTIVITIES, INCLUDING BUT NOT LIMITED TO CHANGES IN MANAGEMENT OR OPERATION OF HUD-FUNDED PROGRAMS OR INITIATIVES. SPECIFIC OUTCOMES WILL VARY BASED ON THE NATURE OF THE ACTIVITIES CARRIED OUT. STANDARD OUTCOME CATEGORIES INCLUDE IMPROVED CAPACITY TO DESIGN PROGRAMS, POLICIES, AND STRATEGIES AS WELL AS TO DELIVER PROJECTS, PROGRAMS, OR SYSTEMS THAT ADDRESS COMMUNITY NEEDS AS DEFINED IN THE TECHNICAL ASSISTANCE (TA) SCOPE.; INTENDED BENEFICIARIES: BENEFICIARIES INCLUDE HUD CUSTOMER ORGANIZATIONS AND WILL VARY BY ACTIVITY. HUD CUSTOMER ORGANIZATIONS INCLUDE STATE AND LOCAL GRANTEES, PUBLIC HOUSING AGENCIES (PHAS), OWNERS AND MANAGERS OF HUD-ASSISTED HOUSING, CONTINUUM OF CARE (COCS), NON-PROFIT GRANTEES, HOMELESS MANAGEMENT INFORMATION SYSTEM (HMIS) LEADS, HUD-APPROVED HOUSING COUNSELING AGENCIES AND COUNSELORS, TRIBAL ORGANIZATIONS, INDIAN TRIBES, TRIBALLY DESIGNATED HOUSING ENTITIES (TDHES), FEDERAL HOUSING ADMINISTRATION (FHA) APPROVED MULTIFAMILY LENDERS, RESIDENTS AND PARTICIPANTS IN HUD-FUNDED PROGRAMS AND INITIATIVES. SELECTED AWARD RECIPIENTS WILL BE DEPLOYED AS HUD DEEMS MOST NECESSARY ACROSS THE COUNTRY TO ASSIST ORGANIZATIONS RECEIVING HUD FUNDS TO IMPROVE PERFORMANCE AND MANAGEMENT OF HUD FUNDS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

RURAL PUBLIC HEALTH WORKFORCE TRAINING NETWORK PROGRAM - APPLICANT ORGANIZATION INFORMATION: KANSAS CLINICAL IMPROVEMENT COLLABORATIVE, LLC (KCIC) 1809 E. 27TH HAYS, KANSAS 67601 CLINICALLY INTEGRATED NETWORK HTTP://KCIC-CARE.COM/ PROJECT DIRECTOR: JENNIFER DREHER, RN PROGRAM MANAGER 785-621-6556 JENNIFER.DREHER@KHSC-KU.COM PROJECT TRACK:: TRACK #4 TARGET SERVICE AREA: THE FOLLOWING RURAL KANSAS COUNTIES:ATCHISON, BARTON, CHEYENNE, CLARK, CLAY, CLOUD, DECATUR, DICKINSON, EDWARDS, ELLIS, ELLSWORTH , FINNEY, GOVE, GRAHAM, GREELEY, HASKELL, JACKSON, KEARNY, LABETTE, LINCOLN, LOGAN, LYON, MCPHERSON, MITCHELL, MONTGOMERY, MORTON, NEOSHO, NESS, NORTON, OSBORNE, PAWNEE, PHILLIPS, PRATT, REPUBLIC , ROOKS, RUSSELL , SCOTT, SEDGWICK, SHERIDAN, SHERMAN, SMITH, STANTON , TREGO, WASHINGTON, WICHITA LIST OF PROPOSED NETWORK PARTNER ORGANIZATIONS: CLAY COUNTY MEDICAL CENTER; EDWARDS COUNTY HOSPITAL AND HEALTHCARE CENTER; FIRST CARE CLINIC; GREELEY COUNTY HEALTH SERVICES, INC.; KCIC; LABETTE COUNTY MEDICAL CENTER; MINNEOLA DISTRICT HOSPITAL; NORTHWEST KANSAS TECHNICAL COLLEGE; RUSSELL REGIONAL HOSPITAL; SCOTT COUNTY HOSPITAL; ST CATHERINE HOSPITAL; UNIVERSITY OF KANSAS MEDICAL CENTER - KUMC CENTER FOR RURAL HEALTH TOTAL FUNDING AMOUNT REQUESTED: $1,544,282.50 CAPACITY TO SERVE RURAL UNDERSERVED POPULATIONS: FORMED IN 2014, KCIC IS A RURAL CLINICALLY INTEGRATED NETWORK COMPRISED OF 78 ORGANIZATIONS ACROSS 70 RURAL KANSAS COUNTIES. KCIC ENGAGES THESE PROVIDERS IN ONGOING PERFORMANCE IMPROVEMENT INITIATIVES, INCLUDING MANAGEMENT OF TIME-SENSITIVE DIAGNOSES AND CHRONIC CONDITIONS. SUPPORTED BY THE UNIVERSITY OF KANSAS HEALTH SYSTEM, THE STATE’S ONLY ACADEMIC MEDICAL CENTER, KCIC’S ACTIVITIES ARE LED BY AN EXPERIENCED MANAGEMENT TEAM AND STAFF MEMBERS. THIS TEAM ENGAGES DIRECTLY WITH PARTICIPATING ORGANIZATIONS, PROVIDING ON-SITE EDUCATION AND SUPPORT RELATING TO ALL INITIATIVES. KCIC’S GOVERNING BODY IS COMPRISED OF PARTICIPANT REPRESENTATIVES, ENSURING FULL ENGAGEMENT IN PLANNING AND EXECUTION OF STR ATEGY. KCIC HAS SUCCESSFULLY MANAGED CMMI AND HRSA GRANTS. KCIC HAS PROVIDED VITAL CLINICAL AND OPERATIONAL SUPPORT FOR ITS PARTICIPANTS IN RESPONDING TO COVID-19. KCIC’S CENTRALIZED TEAM OF HEALTH COACHES HAS FURNISHED CHRONIC CARE MANAGEMENT SERVICES FOR NEARLY 7,200 UNIQUE RURAL MEDICARE BENEFICIARIES. FUNDING PREFERENCE: KCIC IS REQUESTING A FUNDING PREFERENCE BASED ON QUALIFICATION 1. AS DOCUMENTED IN ATTACHMENT 10, ALL NETWORK MEMBERS ARE LOCATED IN COUNTIES DESIGNATED AS HPSAS. KCIC ALSO IS REQUESTING SPECIAL CONSIDERATION BASED ON THE INCLUSION OF A SIGNED MOU WITH ALL NETWORK PARTNERS INCLUDED IN ATTACHMENT 11.

MULTI-STATE MENTORING INITIATIVE

STRENGTHENING CAPACITY TO ORGANIZE FOR INTERESTS AND TO PROTECT LEGAL RIGHTS

YOUTH BUILD

PACT-PARTNERS FOR SUCCESS

MUNICIPAL COMMUNITY COLLABORATION FOR PREVENTION

BENNINGTON COUNTY VERMONT AND BEYONDBUILDING REGIONAL INFRASTRUCTURE AND PARTNERSHIPS TO REDUCE SUBSTANCE MISUSE

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM ? NEONATAL ABSTINENCE SYNDROME - RURAL COMMUNITIES OPIOID RESPONSE PROGRAM – NEONATAL ABSTINENCE SYNDROME

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM-IMPACT - SOUTHERN HEALTHCARE COLLABORATION, INC. IS A NONPROFIT AGENCY WORKING TO SUPPORT THE RURAL HEALTHCARE PROVIDER CLINICAL INTEGRATION AND NETWORK INFRASTRUCTURE, ENABLING THE SYSTEM TO EXPAND OUTREACH AND INCREASE ACCESS TO CARE FOR RURAL COMMUNITIES. SHC IS ON A MISSION TO SUPPORT RURAL HEALTHCARE PROVIDER CLINICAL INTEGRATION AND A NETWORK INFRASTRUCTURE THAT WILL ENABLE PARTICIPANTS TO COORDINATE CARE, EXPAND OUTREACH, AND INCREASE ACCESS TO CARE FOR RURAL COMMUNITIES. SUBSTANCE USE DISORDER HAS BECOME A WIDESPREAD PUBLIC HEALTH CHALLENGE THROUGHOUT RURAL GEORGIA, AND LOCAL SAFETY NET PROVIDERS LACK THE AWARENESS, TRAINING, AND RESOURCES NEEDED TO ADDRESS THE NEEDS OF ADULTS, FAMILIES, AND YOUTH IMPACTED BY THE OPIOID EPIDEMIC. SOUTHERN HEALTHCARE COLLABORATION, INC., HAS ASSEMBLED A CONSORTIUM THAT INCLUDES SERVICE PROVIDERS ACROSS PRIMARY CARE, CRISIS CARE, AND HEALTHCARE WORKFORCE DEVELOPMENT SECTORS IN RURAL SOUTHEAST GEORGIA TO CREATE A COMPREHENSIVE AND SUSTAINABLE SERVICE EXPANSION. THE TARGETED RURAL SERVICE AREA INCLUDES APPLING COUNTY AND BACON COUNTY, ELIGIBLE AS DEFINED BY THE RURAL HEALTH GRANTS ELIGIBILITY ANALYZER.WITH RCORP-IMPACT FUNDING, SHC WILL LEAD THE CONSORTIUM TO EXPAND EXISTING AND ESTABLISH NEW SERVICES IN APPLING AND BACON COUNTIES. SOUTHERN HEALTHCARE COLLABORATION, INC. WILL LEVERAGE THE POWER OF THE ESTABLISHED CONSORTIUM TO BRING PRIMARY CARE, BEHAVIORAL HEALTH, MAT, AND OB-GYN SERVICES TO RURAL GEORGIA UNDER ONE ROOF, WHILE CREATING NEW OPPORTUNITIES TO BUILD A RESPONSIVE WORKFORCE. CONSORTIUM MEMBERS WILL INCLUDE: HEALTHIE COMMUNITY CENTER OF BAXLEY, HEALTHIE COMMUNITY CENTER OF SURRENCY, HEALTHIE COMMUNITY CENTER OF ALMA, SOUTHERN GEORGIA PHYSICIANS GROUP, BACON COUNTY HEALTH SYSTEM, SOUTHERN PHARMACARE, VALDOSTA STATE UNIVERSITY, AND APPLING COUNTY SCHOOLS. PROPOSED TREATMENT AND RECOVERY EXPANSIONS WILL ADDRESS THE NEED FOR SUD SERVICES THAT REACH ADULTS, CHILDREN, AND ADOLESCENTS, AND PREGNANT / PARENTING WO MEN, STRENGTHENING THE WEB OF SERVICES AVAILABLE, INCREASING CASE LOAD CAPACITY, AND REDUCING WAITING PERIODS FOR VULNERABLE INDIVIDUALS. IN TOTAL, AT LEAST 970 INDIVIDUALS WILL BENEFIT IN YEAR ONE, TO INCREASE BY AT LEAST 100 INDIVIDUALS ANNUALLY.

PROMOTING RESPONSIBLE FATHERHOOD

SEE NOTICE OF AWARD, ATTACHMENT 1 - TERMS AND CONDITIONS, ATTACHMENT D - STATEMENT OF WORK, ABSTRACT.

MANY MENTORING PROGRAM

YOUTH COLLABORATORY IS THE CURRENT TRAINING AND TECHNICAL ASSISTANCE (TTA) PROVIDER AND IS APPLYING UNDER CATEGORY 2: TTA TO CONTINUE THIS WORK. ITS GOAL IS TO PREVENT AND REDUCE THE SEX AND/OR LABOR TRAFFICKING OF GIRLS, YOUNG WOMEN, AND GENDER EXPANSIVE PEOPLE OF COLOR AGES 12- 25, PARTICULARLY BLACK YOUNG PEOPLE AND THOSE WHO HAVE EXPERIENCED MIGRATION/ IMMIGRATION. THROUGH THIS NATIONALLY SCOPED PROJECT (SERVICE AREA), ITS PURPOSE IS TO CREATE TRAINING AND RESOURCES TO EXPAND THE SKILLS OF CATEGORY 1 GRANTEES AND OTHER STAKEHOLDERS WORKING TO PREVENT TRAFFICKING OF BLACK GIRLS AND YOUNG WOMEN (INTENDED BENEFICIARIES). PRIMARY ACTIVITIES TO ACHIEVE THIS PURPOSE INCLUDE: 1) COMPLETING INDIVIDUAL BASELINE ASSESSMENTS FOR CATEGORY 1 GRANTEES; 2) CO-CREATING TTA PLANS WITH CATEGORY 1 GRANTEES BASED ON STRENGTHS AND NEEDS IDENTIFIED IN THE BASELINE ASSESSMENT; 3) PROVIDING TTA BASED ON THE NEEDS OF AND TRENDS ACROSS CATEGORY 1 GRANTEES; 4) CONVENING A PEER-TO-PEER LEARNING COMMUNITY FOR CATEGORY 1 GRANTEES, LOCAL STAKEHOLDERS, AND NON-OVC FUNDED SERVICE PROVIDERS; 5) DEVELOPING ONLINE/WRITTEN RESOURCES, TOOLS, AND TRAININGS ADDRESSING PREVENTION AND EARLY INTERVENTION SPECIFICALLY RELATED TO BLACK GIRLS/YOUNG WOMEN AND GENDER EXPANSIVE YOUNG PEOPLE, AS WELL AS YOUNG PEOPLE WITH EXPERIENCES OF MIGRATION; 6) HOSTING ANNUAL GRANTEE MEETING FOR ALL CATEGORY 1 GRANTEES; AND 7) SUBMITTING FINANCIAL AND PROGRAMMATIC REPORTS IN JUSTGRANTS. EXPECTED OUTCOMES INCLUDE % OF TA RECIPIENTS THAT IMPLEMENT NEW/IMPROVED PRACTICES AND % OF TRAINING ATTENDEES THAT INCREASE KNOWLEDGE. PARTNER AND SUBRECIPIENT, RIAN IMMIGRANT CENTER, BRING THEIR EXPERIENCE AND CONNECTION TO STAKEHOLDERS IN THE IMMIGRATION FIELD AND EXPERTISE PROVIDING LEGAL SERVICES, RESOURCES, AND SUPPORT TO NEWCOMERS. YOUTH COLLABORATORY ALSO PARTNERS WITH OTHER NATIONAL TTA PROVIDERS THAT SHARE STRATEGIES AND DISSEMINATE BEST PRACTICES, AND ITS GIRLS ACTION BOARD, WHO ARE CONSULTANTS PAID TO USE THEIR LIVED EXPERTISE TO INFORM AND PROVIDE TTA.

NOVEL DEEP LEARNING STRATEGY TO BETTER PREDICT PHARMACOLOGICAL PROPERTIES OF CANDIDATE DRUGS AND FOCUS DISCOVERY EFFORTS

DIGITAL REPRESENTATION OF CHEMICAL MIXTURES TO AID DRUG DISCOVERY AND FORMULATION

HEARTH TECHNICAL ASSISTANCE

COMMUNITY COMPASS TECHNICAL ASSISTANCE AND CAPACITY BUILDING

SNAP PROGRAM ACCESS EBT PROJECT

INTELLIGENT CHEMICAL STRUCTURE BROWSER FOR DRUG DISCOVERY AND OPTIMIZATION - PROJECT SUMMARY COLLABORATIVE DRUG DISCOVERY, INC. (CDD) PROPOSES TO DEVELOP A NOVEL INTELLIGENT DATA BROWSER THAT WILL ENABLE MEDICINAL CHEMISTS DEVELOPING NEW DRUG COMPOUNDS TO MORE EFFICIENTLY BROWSE AND ORGANIZE EXPERIMENTAL DATA IN AN INTUITIVE WAY. THE PROPOSED BROWSER WILL ESSENTIALLY “HYPERLINK” CHEMICAL SPACE AND ALLOW CHEMISTS TO NAVIGATE EASILY AMONG COMPOUNDS IN A CHEMICAL LEAD SERIES FOLLOWING THE SAME PATHWAYS THAT LEAD FROM ONE COMPOUND TO THE NEXT IN THE MENTAL MODELS THAT THEY INTUITIVELY MAP IN THEIR HEADS. NAVIGATING THROUGH AND EXTENDING A LEAD SERIES TO DISCOVER THE OPTIMAL DRUG CANDIDATE TO ADVANCE INTO ANIMAL STUDIES AND CLINICAL TRIALS COMPRISES A CRITICAL STAGE OF THE DRUG DISCOVERY PIPELINE: THE SUCCESS OF LARGE SUBSEQUENT INVESTMENTS DEPENDS ON MAKING THE RIGHT DECISION. THIS STAGE ALSO ESPECIALLY EMPHASIZES CREATIVE AND INTUITIVE THINKING. EXISTING SOFTWARE THAT ASSISTS SCIENTISTS ENGAGED IN THIS TASK TABULATES DATA IN FORMATS THAT MAKE IT DIFFICULT TO ASSEMBLE AND COMPARE THE ESSENTIAL DATA NEEDED TO RAPIDLY EXPLORE IDEAS ABOUT HOW TO FURTHER OPTIMIZE PROMISING CANDIDATES. OUR PROPOSED INTELLIGENT BROWSER WILL SUPPORT MORE NATURAL AND INTUITIVE WORKFLOWS. A KEY ENABLING INNOVATION FOR THIS TECHNOLOGY IS A METHODOLOGY THAT WE HAVE DEVELOPED TO ORGANIZE MOLECULAR STRUCTURES THROUGH A PARTIAL ORDERING BASED ON THE SUBSTRUCTURE-SUPERSTRUCTURE RELATION AS A HASSE DIAGRAM. OUR SEMILATTICE REPRESENTATION PROVIDES A MACHINE COMPUTABLE FORMAT THAT CAN CAPTURE THE RELATIONSHIPS AMONG RELATED CHEMICAL ENTITIES THAT A MEDICINAL CHEMIST INTUITS. EXPECTED KEY IMPACTS INCLUDE (1) FASTER DEVELOPMENT OF LEAD SERIES INTO DRUG CANDIDATES, (2) COST SAVINGS DUE TO MORE EFFICIENT USE OF SYNTHESIS AND ASSAY RESOURCES, AND MOST IMPORTANTLY (3) BETTER SCIENTIFIC DECISIONS ABOUT WHICH COMPOUNDS TO PURSUE AND ADVANCE INTO THE CLINICAL PIPELINE. BETTER DECISIONS AT THIS STAGE IN THE DRUG DISCOVERY PROCESS SHOULD INCREASE THE PROBABILITY THAT DRUG CANDIDATES THAT ARE CHOSEN WILL SUCCESSFULLY EMERGE THROUGH THE CLINICAL PIPELINE AS FDA APPROVED DRUGS, AND IMPROVE THE EFFECTIVENESS AND SAFETY PROFILE OF THOSE DRUGS. EVEN A SMALL INCREASE IN THESE PROBABILITIES MULTIPLIED BY THE SIZE OF THE INVESTMENTS REQUIRED TO TAKE DRUGS THROUGH CLINICAL TRIALS TRANSLATES INTO A LARGE VALUE. WE HAVE VALIDATED THIS PERCEPTION OF VALUE IN PRELIMINARY MARKET RESEARCH WITH POTENTIAL PHARMACEUTICAL COMPANY CUSTOMERS. !

EVALUATING PAYMENT REFORM AND PROVIDER PRACTICES TO IMPROVE HEALTH OUTCOMES IN CH

PURPOSE: THE PURPOSE OF THIS AWARD IS TO BUILD THE CAPACITY OF HUD'S SPECIAL NEEDS ASSISTANCE PROGRAMS CUSTOMER ORGANIZATIONS TO DEPLOY THE YOUTH HOMELESSNESS DEMONSTRATION PROGRAM (YHDP) EFFECTIVELY AND IN COMPLIANCE WITH ASSOCIATED RULES AND REGULATIONS.; ACTIVITIES TO BE PERFORMED: HUD WILL IDENTIFY SPECIFIC TECHNICAL ASSISTANCE NEEDS TO BE ADDRESSED THROUGH A DEMAND-RESPONSE PROGRAM MODEL. THE RECIPIENT MAY RESPOND TO THOSE NEEDS THROUGH A RANGE OF ELIGIBLE ACTIVITIES: NEEDS ASSESSMENTS; DIRECT TECHNICAL ASSISTANCE AND CAPACITY BUILDING; DEVELOPMENT AND MAINTENANCE OF TOOLS AND PRODUCTS; SELF-DIRECTED AND GROUP LEARNING; KNOWLEDGE MANAGEMENT; DATA ANALYSIS, REPORTING, AND PERFORMANCE MEASUREMENT; ADMINISTRATION; AND COORDINATION.; EXPECTED OUTCOMES: OUTCOMES ARE THE RESULTS OF TECHNICAL ASSISTANCE ACTIVITIES, INCLUDING BUT NOT LIMITED TO CHANGES IN MANAGEMENT OR OPERATION OF HUD-FUNDED PROGRAMS OR INITIATIVES. SPECIFIC OUTCOMES WILL VARY BASED ON THE NATURE OF THE ACTIVITIES CARRIED OUT. STANDARD OUTCOME CATEGORIES INCLUDE IMPROVED CAPACITY TO DESIGN PROGRAMS, POLICIES, AND STRATEGIES AS WELL AS TO DELIVER PROJECTS, PROGRAMS, OR SYSTEMS THAT ADDRESS COMMUNITY NEEDS AS DEFINED IN THE TECHNICAL ASSISTANCE (TA) SCOPE.; INTENDED BENEFICIARIES: BENEFICIARIES INCLUDE YOUTH HOMELESSNESS DEMONSTRATION PROGRAM GRANTEES. SELECTED AWARD RECIPIENTS WILL BE DEPLOYED AS HUD DEEMS MOST NECESSARY ACROSS THE COUNTRY TO ASSIST ORGANIZATIONS RECEIVING HUD FUNDS TO IMPROVE PERFORMANCE AND MANAGEMENT OF HUD FUNDS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

WORC 4

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

UYC 2023 SRAE PROJECT

CAROL M. WHITE PHYSICAL EDUCATION PROGRAM

HOME INVESTMENT PARTNERSHIPS PROGRAM

CPCQC'S STATEWIDE EXPANSION OF QI PROJECTS TO INCREASE CLINICAL-COMMUNITY LINKAGES AND IMPROVE PERINATAL OUTCOMES EQUITABLY. - MATERNAL AND INFANT HEALTH ARE TWO OF THE MOST CRITICAL INDICATORS OF A STATE’S HEALTH. IN COLORADO, DISPARITIES EXIST IN PERINATAL HEALTH OUTCOMES THAT CORRELATE WITH RACIAL, SOCIO-ECONOMIC, GEOGRAPHIC, AND OTHER FACTORS, LEADING TO CHRONIC STRESS AND POOR HEALTH AND RESULTING IN MORE ADVERSE OUTCOMES FOR HISTORICALLY MARGINALIZED POPULATIONS. COLORADO PERINATAL CARE QUALITY COLLABORATIVE (CPCQC) WORKS TO ENSURE THAT BIRTHING INDIVIDUALS AND THEIR FAMILIES RECEIVE CULTURALLY-RELEVANT, SAFE, EQUITABLE, AND HIGH-QUALITY CARE REGARDLESS OF WHO THEY ARE OR WHERE THEY LIVE. WE LEAD SYSTEMS CHANGE IN COLORADO’S PERINATAL HEALTH CARE FACILITIES THROUGH EQUITY-CENTERED BEST PRACTICES, DATA-DRIVEN DECISION-MAKING, AND TRAUMA-INFORMED CARE. CPCQC CURRENTLY LEADS FOUR ACTIVE QUALITY IMPROVEMENT (QI) INITIATIVES THAT ADDRESS HIGH PRIORITY NEEDS ACROSS COLORADO’S PERINATAL POPULATION. THESE PROJECTS SEEK TO SCREEN, SUPPORT, AND TREAT PREGNANT AND BIRTHING PEOPLE FOR SUBSTANCE USE DISORDERS (COLORADO AIM SUBSTANCE USE DISORDER LEARNING COLLABORATIVE-CO AIM: SUD LC); SCREEN AND TREAT SUBSTANCE-EXPOSED NEWBORNS AND SUPPORT PARENTS IN THE PROCESS (COLORADO HOSPITAL SUBSTANCE EXPOSED NEWBORNS COLLABORATIVE-CHOSEN); INCREASE PARENTAL ENGAGEMENT IN THEIR INFANT’S CARE DURING NICU STAYS (DATA-DRIVEN ENGAGEMENT OF FAMILIES TO IMPROVE THE NICU EXPERIENCE IN COLORADO-DEFINE COLORADO); AND REDUCE UNNECESSARY CESAREAN SECTIONS IN LOW-RISK POPULATIONS (SUPPORTING VAGINAL DELIVERY FOR LOW-RISK MOTHERS-SOAR). CPCQC HAS CREATED A CARE NETWORK ACROSS CLINICAL AND COMMUNITY SETTINGS CALLED IMPROVE PERINATAL ACCESS, COORDINATION, AND TREATMENT FOR BEHAVIORAL HEALTH (IMPACT BH) TO HELP FAMILIES OVERCOME BEHAVIORAL HEALTH AND SOCIAL NEEDS. AS PART OF THIS WORK, CPCQC INCLUDES PARTICIPATING HOSPITALS IN THE SUBSTANCE USE AND BEHAVIORAL HEALTH QI PROJECTS MENTIONED ABOVE. CPCQC HAS ALSO LAUNCHED THE FAMILY INTEGRATION TO RESTORE TRUST (FIRST) PROGRAM, A TWO-PHASE, COMMUNITY-FOCUSED EFFORT TO TRAIN AND INTEGRATE PATIENT-FAMILY PARTNERS FROM DIVERSE BACKGROUNDS INTO LEADERSHIP COMMITTEES AND WORKGROUPS WITHIN OUR ORGANIZATION. CPCQC IS APPLYING FOR CDC-RFA-DP22-2207 COMPONENT A FUNDING TO ADDRESS THE PERINATAL HEALTH CARE NEEDS IN COLORADO BY EXPANDING QI PROJECTS ACROSS THE STATE, CREATING AND ENHANCING CLINICAL AND COMMUNITY LINKAGES, AND CONNECTING PROJECTS THAT ENCOMPASS THE MATERNAL-INFANT DYAD, STARTING IN HIGH-NEED REGIONS IDENTIFIED AND SELECTED BASED ON PERINATAL HEALTH OUTCOMES DATA WITH AN EMPHASIS ON REGIONS WITH INEQUITABLE OUTCOMES FOR SUBPOPULATIONS. CPCQC WILL EMPHASIZE CLINICAL-COMMUNITY LINKAGES BY ESTABLISHING CARE NETWORKS THAT SPAN PRENATAL, HOSPITAL, AND POSTPARTUM NEEDS AND INTEGRATE HEALTH CARE DELIVERY WITH COMMUNITY STRATEGIES THAT ARE DEVELOPED AND GUIDED BY THOSE WITH LIVED EXPERIENCE. OUTCOMES: BY SEPTEMBER 29, 2023, CPCQC WILL: INCREASE OVERALL PARTICIPATION OF HEALTHCARE FACILITIES PARTICIPATING IN AIM SUD LC, CHOSEN, AND DEFINE BY 20%, SPECIFICALLY TARGETING FACILITIES THAT SERVE DISPROPORTIONATELY IMPACTED PREGNANT AND POSTPARTUM INDIVIDUALS, INFANTS, AND THEIR FAMILIES. SELECT ONE NEW PERINATAL QI INITIATIVE TO BEGIN IMPLEMENTATION PLANNING IN 2024. BY SEPTEMBER 29 2027, CPCQC WILL: INCREASE OVERALL PARTICIPATION OF HEALTHCARE FACILITIES PARTICIPATING IN ONE OR MORE QI INITIATIVES TO AT LEAST 75% EXPANDING ITS CAPACITY TO SERVE DISPROPORTIONATELY IMPACTED PREGNANT AND POSTPARTUM INDIVIDUALS, INFANTS, AND THEIR FAMILIES.

RURAL CAPACITY BUILDING FOR COMMUNITY DEVELOPMENT AND AFFORDABLE HOUSING GRANTS

ENACTING A SCALABLE EVIDENCE-BASED CIVICS AND AMERICAN HISTORY INSTRUCTIONAL SYSTEM APPROACH

COMMUNITY-BASED APPROACHES TO REDUCING THE INCIDENCE OF CARDIOVASCULAR DISEASES AND DIABETES AMONG AFRICAN AMERICAN AND AFRICAN IMMIGRANT AND REFUGEE

ADDITIVE MANUFACTURING ENABLED MODULAR SHELLS FOR LARGE WIND BLADES

THE BIG SHOW IN BOLOLAND

SBIR PHASE II: AI-AUGMENTED MENTORSHIP: BRIDGING EDUCATION TO WORKFORCE PREPAREDNESS -THIS SBIR PHASE II PROJECT TACKLES THE CRITICAL SKILLS GAP THROUGH COLLABORATIVE PROJECT-BASED LEARNING (CPBL). BY SEAMLESSLY INTEGRATING REAL-WORLD PROJECTS WITH CURRICULUM, STUDENTS GAIN ESSENTIAL SOFT SKILLS LIKE PROBLEM-SOLVING, COMMUNICATION, AND TEAMWORK, AND HARD SKILLS RELEVANT TO SPECIFIC INDUSTRIES, MAKING THEM ADAPTABLE ACROSS FIELDS. CPBL PROVIDES STUDENTS WITH AUTHENTIC CHALLENGES THROUGH PROJECT-BASED LEARNING ENHANCED WITH INDUSTRY MENTORS TO FOSTER PROJECT MANAGEMENT AND CRITICAL WORKPLACE SKILLS ESSENTIAL FOR PROFESSIONAL SUCCESS. MEANINGFUL PROJECTS NOT ONLY BOOST ENGAGEMENT AND UNDERSTANDING BUT, WHEN COUPLED WITH INDUSTRY PARTNERSHIPS, OFFER MINI-INTERNSHIPS AND CAREER GUIDANCE. INDUSTRY PROFESSIONALS FURTHER BOLSTER THIS COLLABORATIVE ENVIRONMENT BY SHARING THEIR EXPERTISE AND FACILITATING TEAM DYNAMICS, PROVIDING INVALUABLE MENTORSHIP AND REAL-WORLD CONTEXT TO STUDENT LEARNING. THE SOFTWARE ALSO EMPOWERS ACADEMIC INSTITUTIONS TO EVALUATE AND ASSESS STUDENT ACQUISITION OF THESE CORE WORKFORCE SKILLS THROUGH EMBEDDED ASSESSMENTS WITHIN THE CPBL FRAMEWORK, ENSURING GRADUATES ARE TRULY PREPARED FOR THE DEMANDS OF THE MODERN WORKPLACE. THIS INNOVATIVE APPROACH BRIDGES THE GAP BETWEEN EDUCATION AND WORKFORCE PREPAREDNESS, EMPOWERING STUDENTS WITH THE SKILLS THEY NEED FOR FUTURE SUCCESS. TO BRIDGE THE WORKFORCE SKILLS GAP, THIS PROJECT PROPOSES AN AI-POWERED COLLABORATIVE PROJECT-BASED LEARNING (CPBL) SOFTWARE PLATFORM. WE WILL FIRST ESTABLISH A BASELINE BY EVALUATING THE PLATFORM'S CORE COLLABORATIVE FUNCTIONALITIES ? INCLUDING GROUP FORMATION, PROGRESS TRACKING, AND MENTORSHIP INTEGRATION ? FROM THE PERSPECTIVES OF STUDENTS, INSTRUCTORS, AND INDUSTRY MENTORS. THIS INITIAL EVALUATION WILL UTILIZE A MIXED-METHODS APPROACH, COMBINING QUANTITATIVE DATA AND QUALITATIVE FEEDBACK. THE FINDINGS WILL SERVE AS A CRUCIAL BENCHMARK TO ASSESS THE ADDED VALUE OF THE AI COMPONENT ONCE INTEGRATED. THE PLATFORM ITSELF IS DESIGNED TO ADDRESS THE ISSUE OF LIMITED PRACTICAL SKILL DEVELOPMENT BY ENABLING INSTRUCTORS TO DESIGN CPBL ACTIVITIES WITHIN THEIR CURRICULUM, SEAMLESSLY GROUP STUDENTS BASED ON SKILL SETS, AND TRACK PROGRESS. IT FURTHER INTEGRATES INDUSTRY MENTORS FOR REAL-WORLD GUIDANCE AND UTILIZES EMBEDDED ASSESSMENTS TO EVALUATE STUDENT ACQUISITION OF CORE COMPETENCIES. DEVELOPMENT WILL LEVERAGE BOTH QUANTITATIVE AND QUALITATIVE ANALYSIS, WITH REAL-TIME USER FEEDBACK DRIVING ITERATIVE IMPROVEMENTS THROUGHOUT. THE PLATFORM'S AI COMPONENT, DISTINCT FROM EXISTING SOLUTIONS, WILL BE DESIGNED TO MODEL STUDENT PROFILES, PROVIDE PERSONALIZED LEARNING SUPPORT, AND OPERATE WITH MINIMAL SUPERVISION. THIS INNOVATIVE APPROACH, MEASURED THROUGH A MIXED-METHODS EVALUATION POST-AI INTEGRATION, WILL DETERMINE THE PLATFORM'S OVERALL EFFECTIVENESS IN PROMOTING SKILL DEVELOPMENT, FOSTERING ENGAGEMENT, AND PREPARING GRADUATES FOR THE MODERN WORKFORCE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

FUTURE GENERATIONS COLLABORATIVE EARLY CHILDHOOD PROJECT

SUPPORTIVE HOUSING PROGRAM

YOUTH BUILD

RURAL CAPACITY BUILDING

COMMUNITY COMPASS TECHNICAL ASSISTANCE AND CAPACITY BUILDING

COMMUNITY COMPASS TECHNICAL ASSISTANCE AND CAPACITY BUILDING

SUPPORTIVE HOUSING PROGRAM

COMMUNITY COMPASS TECHNICAL ASSISTANCE AND CAPACITY BUILDING

PULESA-UGANDA-STRENGTHENING THE BLOOD PRESSURE CARE AND TREATMENT CASCADE FOR UGANDANS LIVING WITH HIV-IMPLEMENTATION STRATEGIES TO SAVE LIVES

YOUTH BUILD

YOUTH BUILD

PREVENTING TRAFFICKING OF GIRLS

YOUTH BUILD

ELEMENTARY AND SECONDARY SCHOOL COUNSELING

CONTINUUM OF CARE PROGRAM

TRANSITIONAL LIVING PROGRAM

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

ARTS IN EDUCATION - PROFESSIONAL DEVELOPMENT FOR MUSIC EDUCATORS

YOUTH COLLABORATORY WILL LEVERAGE ITS EXPERIENCE, IN-DEPTH KNOWLEDGE OF THE PROBLEM, ABILITY TO WORK WITH A FOCUS OF EQUITY ACROSS COMMUNITIES AND SYSTEMS, AND WITH RELIABLE DATA COLLECTION AND ANALYTIC CAPABILITIES TO FULFIL THE GOALS OF CATEGORY 2 TRAINING AND TECHNICAL ASSISTANCE (TTA). YOUTH COLLABORATORY IS APPLYING UNDER PRIORITY AREAS 1A, 2, AND 3 WITH EXPERIENCE AND EXPERTISE IN WORKING TOWARDS RACIAL EQUITY AND REMOVING BARRIERS, SUPPORTING UNDERSERVED RURAL COMMUNITIES, AND ACHIEVING REPUTABLE OUTCOMES.   THE PURPOSE/GOAL OF THE PROGRAM IS TO PROMOTE POSITIVE YOUTH OUTCOMES AND PUBLIC SAFETY FOR ADOLESCENTS EXPERIENCING RISK FACTORS AND YOUTH TRANSITIONING FROM FOSTER CARE THROUGHOUT THE U.S. (SERVICE AREA). TO MEET THIS GOAL, YOUTH COLLABORATORY’S PRIMARY ACTIVITIES INCLUDE PROVIDING TTA AND ACHIEVE THE SEVEN REQUIRED DELIVERABLES (D) THROUGH FOUR PHASES. PHASE I: DISCOVERY D1: DEVELOP TECHNICAL ASSISTANCE PLANS FOR EACH PROJECT SITE WITHIN THE FIRST 4 MONTHS. D2: PLAN AND COORDINATE, IN CONJUNCTION WITH OJJDP, ANNUAL CROSS-SITE MEETINGS OF PROJECT SITE GRANTEES. PHASE 2: LEARNING (MONTHS 6-12, ONGOING) & PHASE 3: INTEGRATION & SUPPORT (MONTHS 12-36, ONGOING) D3: PROVIDE TARGETED CONTENT TRAINING TO PROJECT SITE STAFF AND PARTNERS TO INCREASE THEIR CAPACITY TO IMPLEMENT STRATEGIES TO ADDRESS ISSUES RELATED TO THE TARGET POPULATION OF YOUTH. D4: ESTABLISH TOOLS AND TECHNIQUES FOR WORKING ACROSS DIFFERENT DISCIPLINES TO FACILITATE INFORMATION SHARING, COMMUNICATION, AND COORDINATION. FACILITATE PEER-TO-PEER INFORMATION SHARING AND LEARNING COMMUNITIES (CROSS-SITE MEETINGS) BETWEEN THE PROJECT SITES. PHASE 4: NATIONAL DISSEMINATION & ENGAGEMENT (MONTHS 1-36) D5: DEVELOP AND DISSEMINATE RESOURCES ON BEST PRACTICES AND LESSONS LEARNED FROM THE PROJECT SITES. D6: DEVELOP AND DELIVER GENERAL TRAINING ACTIVITIES ON RESIDENTIAL-BASED INNOVATIVE CARE, TREATMENT, AND SERVICES FOR COMMUNITIES NOT FUNDED THROUGH THIS PROJECT. D7: PRODUCE WRITTEN SYNOPSES OR SUMMARIES OF ALL MEETINGS, ONSITE VISITS, CONFERENCE CALLS, AND TRAININGS, AND WILL PROVIDE THEM TO OJJDP.   THE INTENDED BENEFICIARIES ARE CATEGORY 1 PROJECT SITES (GOVERNMENTAL AND TRIBAL ENTITIES, INDEPENDENT SCHOOL DISTRICTS, AND NON-PROFIT AND FOR-PROFIT ORGANIZATIONS) AND OTHER STAKEHOLDERS SUPPORTING ADOLESCENTS EXPERIENCING RISK FACTORS AND YOUTH TRANSITIONING FROM FOSTER CARE.   OUR EXPECTED OUTCOMES ARE TO DEVELOP AND EXPAND THE SKILLS OF PROGRAM PROVIDERS AND OTHER STAKEHOLDERS WORKING WITH THE TARGET POPULATION OF YOUTH, AND INCREASE AWARENESS OF INNOVATIVE TREATMENT MODELS FOR THIS TARGET POPULATION OF YOUTH.

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

WARD 8 DRUG-FREE COALITION

PROPOSED 66 WEST TRANSITIONAL LIVING PROGRAM, AN EMPLOYMENT- AND EDUCATION-FOCUSED, TRAUMA-INFORMED SERVICES PROGRAM FOR YOUTH IN A CUSTOM-DESIGNED SUPERVISED APARTMENT BUILDING LOCATED IN EDINA, MN

YOUTH BUILD

CONTINUUM OF CARE PROGRAM

THIS AWARD IS SUBJECT TO DEPARTMENT OF HEALTH AND HUMAN SERVICES AMERICAN RECOVERY AND RE

DEMENTIA CAPABLE NAPA COUNTY: SYMPTOM MANAGEMENT TRAINING AND SUPPORT FOR PERSONS WITH ADRD AND THEIR CAREGIVERS AND TRAINING FOR COMMUNITY MEMBERS TO IDENTIFY ADRD RISK FACTORS MAKE REFERRALS

THE PROJECT PROPOSED BY COLLABORATIVE SOLUTIONS FOR COMMUNITIES OFFERS A COMPREHENSIVE RANGE OF SERVICES INCLUDING TRAINING FOR SCHOOL PERSONNEL AND STUDENTS, VIOLENCE INTERVENTION STRATEGIES, AND VARIOUS SCHOOL SAFETY SOLUTIONS. THE PROGRAM FOCUSES ON IMPLEMENTING EVIDENCE-BASED EDUCATIONAL CURRICULA, VIOLENCE INTERVENTION AND PREVENTION, MEDIATION, SOCIO-EMOTIONAL DEVELOPMENT, AND TRAINING FOR SCHOOL PERSONNEL. THE TRAINING MATERIALS THAT WILL EDUCATE THE STUDENTS ABOUT TRAUMA AND ITS NEGATIVE IMPACT ON BEHAVIOR AND WELL-BEING, AS WELL AS HEALTHY SOCIOEMOTIONAL SKILLS, INCLUDING THE TRAUMA, ADDICTIONS, MENTAL HEALTH, AND RECOVERY FOR YOUTH (TAMAR-Y) AND THE HIGH SCHOOL HEALTH CURRICULUM (HSHC). THE TAMAR PROGRAM WAS ORIGINALLY DESIGNED FOR THE MARYLAND DEPARTMENT OF JUVENILE SERVICES (DJS) IN PARTNERSHIP WITH YOUNG INDIVIDUALS, FAMILIES, AND DJS STAFF, LEADING TO THE CREATION OF TAMAR-Y. THIS THERAPEUTIC INITIATIVE COMBINES TRAUMA EDUCATION WITH PRACTICAL TECHNIQUES TO HELP PARTICIPANTS IDENTIFY TRIGGERS AND DEVELOP SKILLS TO MANAGE TRAUMA SYMPTOMS EFFECTIVELY. UTILIZING EXPRESSIVE ARTS THERAPIES, THE PROGRAM ENGAGES YOUTH IN A WAY THAT IS BOTH AGE-APPROPRIATE AND MEANINGFUL, ENCOURAGING EXPLORATION OF EMOTIONS AND EXPERIENCES TO DEEPEN SELF-AWARENESS AND RESPONSES TO TRAUMA. THE HSHC, A PUBLICATION OF THE COLORADO DEPARTMENT OF EDUCATION, IS A CURRICULUM THAT PLACES A STRONG EMPHASIS ON SOCIAL AND EMOTIONAL SKILLS, PROVIDING STUDENTS WITH UP-TO-DATE INFORMATION WHILE COVERING VARIOUS RELEVANT TOPICS. WITH SIX UNITS, EACH CONTAINING SIX SESSIONS, THE CURRICULUM COVERS A WIDE RANGE OF TOPICS INCLUDING HEALTH, NUTRITION, VIOLENCE PREVENTION, COMMUNICATION SKILLS, AND MORE.

THE EXPANDING MONTANA RURAL STUDENT MENTAL HEALTH SUPPORTS INITIATIVE AIMS TO EXTEND MENTAL HEALTH RESOURCES TO UNDERSERVED RURAL, TRIBAL, AND FRONTIER SCHOOLS IN WESTERN MONTANA. THIS PROJECT WILL PROVIDE COMPREHENSIVE SCHOOL MENTAL HEALTH SERVICES, INCLUDING TRAUMA-INFORMED CARE, WELLNESS TRAINING, CURRICULUM, AND TELETHERAPY TO ESTABLISH SAFE SCHOOL ENVIRONMENTS AND ENSURE EQUITABLE ACCESS TO MENTAL HEALTH SERVICES. EXPANDING MONTANA RURAL STUDENT MENTAL HEALTH SUPPORTS INCLUDES FIVE KEY COMPONENTS: THE MONTANA CARES APP FOR 24/7 ACCESS TO HELP, A RESOURCE NAVIGATOR FOR IN-FIELD SUPPORT, EXPANDED TELETHERAPY SERVICES, LIVE CLIMATE AND CULTURE PROGRAMMING THROUGH RACHEL'S CHALLENGE, AND ENHANCED MENTAL WELLNESS AND RESILIENCY TRAINING. THE MONTANA CARES APP PROVIDES CONTINUOUS ACCESS TO CRISIS COUNSELORS AND LOCAL RESOURCES, ENSURING IMMEDIATE AND APPROPRIATE SUPPORT. THE PROJECT BUILDS ON THE SUCCESS OF MONTANA CARES, WHICH CURRENTLY SERVES OVER 14,000 STUDENTS AND THEIR FAMILIES. EXPANDING CARE IN MONTANA WILL EXTEND THESE SERVICES TO THE WESTERN REGIONS, ADDRESSING SIGNIFICANT INEQUITIES IN SCHOOL-BASED MENTAL HEALTH RESOURCES, AND SERVING AN ADDITIONAL 13,000+ STUDENTS AND THEIR SCHOOL COMMUNITY FAMILIES.

EQUITY OF SERVICES FOR RURAL, TRIBAL, AND FRONTIER SCHOOLS ACROSS MONTANA UNDER STOP ACT CATEGORY 2, PROGRAM AREAS 3) TRAINING SCHOOL PERSONNEL AND EDUCATING STUDENTS ON PREVENTING SCHOOL VIOLENCE, AND 5) HIRING SCHOOL SUPPORT PERSONNEL DIRECTLY SUPPORTING THE PREVENTION OF SCHOOL VIOLENCE, WESTERN MONTANA PROFESSIONAL LEARNING COLLABORATIVE (WMPLC), IN PARTNERSHIP WITH THE MONTANA SMALL SCHOOL ALLIANCE (MSSA), IS PROPOSING A PROJECT TO INCREASE THE EQUITY OF STUDENT SERVICES FOR RURAL, TRIBAL, AND FRONTIER SCHOOLS ACROSS THE STATE OF MONTANA. MSSA HAS CLOSE TO 150 SMALL SCHOOL MEMBER DISTRICTS AND 120 OF THEM ARE OPERATING WITHOUT A SINGLE CREDENTIALED SCHOOL COUNSELOR, LEAVING ONE OF THEIR TEACHERS TO TAKE A SINGLE THREE-HOUR SESSION (PROVIDED BY MSSA) AND THEN TAKE ON THE COUNSELING RESPONSIBILITIES FOR THEIR SCHOOL IN ADDITION TO THEIR TEACHING ROLE. SOME TEACHERS ALSO HAVE THE LIBRARY MEDIA SPECIALIST TASKS AS WELL. THESE RURAL AND TRIBAL SCHOOLS ARE EXCEPTIONALLY UNDER- RESOURCED. THE PURPOSE OF THIS PROJECT IS TO DELIVER TO UNDERSERVED AREAS COMPREHENSIVE SCHOOL COUNSELING, MENTAL HEALTH SERVICES, AND OTHER RESOURCES THAT ARE CRUCIAL FOR CREATING AND SUSTAINING SAFE SCHOOLS. INCREASED ACCESS TO RESOURCES, TRAUMA-INFORMED CARE, SCHOOL COUNSELORS, E-THERAPY ASSESSMENTS AND TREATMENT, AS PROPOSED IN THE PROJECT, IS VITAL TO IMPROVING THE PHYSICAL AND PSYCHOLOGICAL SAFETY OF THE SCHOOL COMMUNITY. THE WMPLC/MSSA PARTNERSHIP AIMS TO SERVE NEARLY 150 SMALL SCHOOL MEMBER DISTRICTS, TRIBAL SCHOOLS, AND FRONTIER SCHOOLS BY PROVIDING COUNSELING SUPPORTS, MENTAL HEALTH SERVICES, AND PROVEN VIOLENCE PREVENTION TOOLS THAT ARE DESPERATELY NEEDED BY STUDENTS, STAFF, AND FAMILIES ACROSS MONTANA.

SBIR PHASE II: AI-DRIVEN ORIENTATION AND MOBILITY SYSTEM FOR THE BLIND

MODIFICATION 2 EXTENDS THE CA FOR ONE MONTH AT NO FURTHER COST.

TO EXPAND POSITIVE KNOWLEDGE, ATTITUDES, AND PRACTICES TOWARDS CULTURE OF LAWFULNESS (COL) AMONG MEXICAN SCHOOL-AGE CHILDREN.

HOMELESS TECHNICAL ASSISTANCE

COOPERATIVE RESEARCH IN UAV APPLICATIONS AND DEMON STRATIONS

IDENTIFICATION OF NOVEL THERAPEUTICS FOR TUBERCULOSIS COMBINING CHEMINFORMATICS,

HAG TECHNICAL ASSISTANCE

RURAL COMMUNITIES OPIOID RESPONSE-IMPLEMENTATION

TEACHING AMERICAN HISTORY GRANTS