Leads Inc

HEAD START: FULL YEAR PART DAYHANDICAPPEDTRAINING AND TECHNICAL ASSISTANCE

HEAD START AND EARLY HEAD START

HEAD START AND EARLY HEAD START

HEAD START AND EARLY HEAD START

HIGH-RESOLUTION, SPINAL CORD STIMULATION FOR NON-OPIOID TREATMENT OF NEUROPATHIC PAIN

HEALTH EDUCATION AND RELATIONSHIP TRAINING SERVICES-MIDDLE SCHOOL (HEARTS-M) PROJECT - THE FLORIDA NON-PROFIT, LIFE-SKILLS, EMPOWERMENT AND DEVELOPMENT SERVICES (LEADS) INC., IS PROPOSING THE HEALTH EDUCATION AND RELATIONSHIP TRAINING SERVICES-MIDDLE SCHOOL (HEARTS-M) PROJECT. HEARTS-M EXPANDS THE SUCCESSFUL HEARTS PROGRAM FOR HIGH SCHOOL STUDENTS (HEARTS-HS) TO SERVE VULNERABLE MIDDLE SCHOOL STUDENTS. THE GOAL OF HEARTS-M IS TO IMPROVE THE OPTIMAL HEALTH OF 1500 BLACK YOUTH) AGES 10-14 (25% FOR APPROXIMATELY 6,000 TOTAL BLACK YOUTH CONNECTED TO THE HUB CHURCHES IN OUR TARGET COUNTIES) AND 220 PARENT/CAREGIVERS ANNUALLY IN 6 FLORIDA COUNTIES WITH HIV RATES HIGHER THAN THE NATIONAL AVERAGE, IN ORDER TO REDUCE TEEN PREGNANCY AND SEXUALLY TRANSMITTED INFECTIONS (HIV/STIS) THROUGH SATURATION OF COMMUNITIES WITH THE GREATEST NEEDS AND DISPARITIES USING A SYSTEMS THINKING APPROACH TO REPLICATE AN EFFECTIVE PROGRAM WITH FIDELITY BY THE END OF THREE-YEARS. THE PROJECT SEEKS TO COMBAT EARLY INITIATION OF SEXUAL ACTIVITY AMONG BLACK YOUTH AGES 10-14 BY PROVIDING MEDICALLY ACCURATE, AGE APPROPRIATE, EVIDENCE-BASED SEXUAL EDUCATION CURRICULUM DEVELOPED BY THE DIBBLE INSTITUTE AND ENTITLED LOVE NOTES SRA EBP.

EHS 2009 ARRA EXPANSION

HEALTH EDUCATION AND RELATIONSHIP TRAINING SERVICES-HIGH SCHOOL (HEARTS-H) PROJECT

SBIR PHASE II: A PRECISION, HIGH-DENSITY STIMULATION ELECTRODE FOR LOW-BACK PAIN RELIEF

FABULOUS RELATIONSHIPS AND INTIMACY EDUCATION THAT NURTURES DEVELOPMENT (FRIEND) PROJECT

RAPID RESPONSE TOXICOLOGY PREDICTION PLATFORM

HEALTH EDUCATION AND RELATIONSHIP TRAINING SERVICES (HEARTS) PROJECT TO ADDRESS THE PROBLEM OF UNINTENDED TEEN PREGNANCY IN SOUTH ST. PETERSBURG, PINELLAS COUNTY, FLORIDA.

AN IMPLANTABLE AND HIGH-DENSITY, MULTIPLEXED MICRO-ECOG SYSTEM

A WIRELESS, IMPLANTABLE VISCERAL NERVE SENSING AND STIMULATION PLATFORM WITH ELECTRODE IMPEDANCE MONITORING

AMERICAN RESCUE PLAN

COMMUNITY FOUNDATIONS THROUGHOUT LATIN AMERICA AND THE CARIBBEAN BENEFIT FROM PARTNERING WITH COMMUNITY FOUNDATIONS IN THE UNITED STATES AND CANADA GIVEN THE SIMILARITIES IN THEIR PROGRAMMING AND COMMUNITY DEVELOPMENT WORK. THE IAF WORKS TO STRENGTHEN THE ABILITY OF LOCAL PHILANTHROPIC ORGANIZATIONS TO DO EFFECTIVE PROGRAMMING BUILD STRONG LASTING PARTNERSHIPS AND UNLOCK ADDITIONAL PUBLIC AND PRIVATE RESOURCES TO MEET THE LONG-TERM DEVELOPMENT NEEDS OF THE COMMUNITIES THEY SERVE. CFLEADS WORKS TO ENGAGE COMMUNITY PHILANTHROPIES COMMUNITY FOUNDATIONS AND LOCALLY-ROOTED INSTITUTIONS FROM THE U.S. CANADA MEXICO BRAZIL AND OTHER COUNTRIES IN THE HEMISPHERE ENCOURAGING PEER-TO-PEER EXCHANGES AWARDING GRANTS FOR MAPPING AND COMMUNITY PROJECTS AND ORGANIZING CONFERENCES TO IMPROVE OVERALL PROGRAMS AND MAKING THEM MORE RESPONSIVE AND CONNECTED TO THE RESIDENTS IN THEIR LOCAL AREAS. THIS GRANT IS PART OF OUR BROADER INITIATIVE TO ENCOURAGE INNOVATIVE AND ENTREPRENEURIAL THINKING TO INCREASE FUNDING SOURCES FOR SUSTAINABLE COMMUNITY-LED DEVELOPMENT.

THE COMMERCIALIZATION OF HIGH-RESOLUTION, SPINAL CORD STIMULATION FOR NON-OPIOID TREATMENT OF NEUROPATHIC PAIN - ABSTRACT DESCRIPTION. OUR FASTTRACK SBIR PROPOSAL HAS DEVELOPED HD64—A HIGH-RESOLUTION, SPINAL CORD STIMULATION THERAPY TO PROVIDE MORE PAIN RELIEF WITH GREATER SPECIFICITY FOR THOSE SUFFERING FROM CHRONIC NEUROPATHIC PAIN AND OPIOID DEPENDENCE. OVER 25 MILLION IN THE U.S. SUFFER FROM DEBILITATING PAIN IN THE TRUNK AND EXTREMITIES AND 55% DEPEND ON OPIOIDS TO EASE THEIR SUFFERING. OPIOID ABUSE HAS CLAIMED THE LIVES OF OVER 200,000 OVER THE PAST DECADE AND HAS RESULTED IN DEVASTATING REDUCTIONS IN QUALITY OF LIFE, IN ABILITY TO WORK, AND IN MENTAL HEALTH FOR THE LIVING. SPINAL CORD STIMULATION (SCS) HAS PROVIDED PAIN RELIEF FOR 60% OF THOSE WITH CHRONIC EXTREMITY PAIN AND ELIMINATED OPIOID USE ENTIRELY IN MORE THAN 50%. DESPITE THESE ADVANTAGES, SCS HAS HAD A LIMITED SUCCESS TREATING ISOLATED PAIN OF THE KNEE, FOOT, GROIN, OR LOW- BACK. THE LATERAL POSITIONED FIBERS OF THE SPINAL CORD (EX. THE DORSAL ROOT ENTRY ZONE AND DORSAL HORN) REPRESENT A MORE SELECTIVE NEURAL TARGETING OPPORTUNITY YET CURRENT, IMPLANTABLE PLATE-TYPE SURGICAL LEADS ARE TOO RIGID AND BULKY TO ACCESS THESE FIBERS WITHOUT A SIGNIFICANT RISK OF PARALYSIS OR NERVE ROOT COMPRESSION. HD64 PROVIDES AN ULTRA-THIN AND CONFORMAL BLANKET OF 60 STIMULATION CONTACTS ACROSS THE ENTIRE WIDTH OF THE SPINAL CORD. ACTIVE-LEAD HD64 TECHNOLOGY EMBEDS A TINY ELECTRONIC CHIP WITHIN THE SURGICAL LEAD AND DOUBLES THE NUMBER OF THERAPY CONTACTS COMPARED WITH CURRENT TECHNOLOGY WITHOUT INCREASING THE NUMBER OF LEAD-WIRES. COLLECTIVELY, THESE FEATURES IMPROVE THERAPY AND SIMPLIFY SURGICAL WORKFLOW. PHASE 2: IN PHASE 2, WE HAVE DEVELOPED THE HD64 ACTIVE LEAD TECHNOLOGY. WE HAVE OBTAINED FDA APPROVAL TO PERFORM AN EARLY FEASIBILITY STUDY HUMAN FEASIBILITY STUDY USING THE ACTIVE HD64 ACTIVE ELECTRODES, AL-EPG WEARABLE STIMULATOR, AND IPAD PROGRAMMER TABLET (N=10 SUBJECTS, N=23 THERAPY GROUPS, N=2 WAVEFORMS). WE HAVE ALSO DEVELOPED IMPLANTABLE PULSE GENERATOR PROTOTYPES AND ARE BEGINNING TO PERFORM MECHANICAL AND ELECTRICAL DESIGN VERIFICATION TESTING AND CHRONIC SAFETY STUDIES IN LARGE ANIMALS TO DEMONSTRATE FUNCTIONAL PERFORMANCE TO INFORM THE FINAL DEVICE. PHASE 2 COMMERCIALIZATION READINESS: THIS COMMERCIALIZATION READINESS PROPOSAL SEEKS TO PERFORM ACTIVITIES TO EXTEND THE BUSINESS DEVELOPMENT OF OUR PHASE 2 SBIR. THIS CRP PROPOSAL WILL ACCELERATE THE COMMERCIALIZATION OF THE HD64 THERAPY SYSTEM BY HIRING A FOCUSED VP OF BUSINESS DEVELOPMENT WHO IS DEDICATED TO COMMERCIALIZATION ACTIVITIES. THE IMPORTANCE AND TIMING OF THIS COMMERCIALIZATION IS SIGNIFICANT AS WE HAVE OBTAINED FDA IDE APPROVAL AND LAUNCHED INTRAOPERATIVE STUDIES. SPECIFICALLY, WE WILL SOURCE AND HIRE A CANDIDATE WHO HAS A MIX OF BUSINESS, NEUROMODULATION, AND MARKETING/SALES SKILLS WHO CAN LEAD FUNDRAISING, STRATEGIC PARTNERSHIPS, AND COMPONENT LICENSING INITIATIVES.

CFLEADS WILL WORK CLOSELY WITH THE IAF THE C.S. MOTT FOUNDATION AND A GROWING NUMBER OF OTHER COMMUNITY FOUNDATIONS HOME TOWN ASSOCIATIONS AND OTHER PARTNERS TO SUPPORT AN EVOLVING TRANSNATIONAL COLLABORATION CALLED BUILDING BROADER COMMUNITIES IN THE AMERICAS. CFLEADS WILL PROVIDE SUBSTANTIVE LOGISTICAL AND ORGANIZATIONAL SUPPORT TO THIS EFFORT TO SUPPORT COMMUNITY-LED PHILANTHROPY IN THE AMERICAS BY BUILDING A VIBRANT TRANSNATIONAL COMMUNITY OF PRACTICE THAT RECOGNIZES THE CHANGING NATURE OF COMMUNITIES IN A GLOBALIZING WORLD. GRANT ACTIVITIES WILL SERVE 100 DIRECT BENEFICIARIES FROM PARTICIPATING INSTITUTIONS AND 10000 INDIRECT BENEFICIARIES IN THE COMMUNITIES SERVED BY THESE INSTITUTIONS.

HEAD START: FULL YEAR PART DAYHANDICAPPEDTRAINING AND TECHNICAL ASSISTANCE

SBIR PHASE I: A PRECISION, HIGH-DENSITY STIMULATION ELECTRODE FOR LOW-BACK PAIN RELIEF

RAPID RESPONSE TOXICOLOGY PREDICTION PLATFORM

COMPUTATIONAL PLATFORM FOR GREEN CHEMISTRY