University Of Utah

ENHANCED GEOTHERMAL SYSTEM CONCEPT TESTING AND DEVELOPMENT AT THE MILFORD CITY, UTAH FORGE SITE

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND INSTITUTIONAL PORTION

CANCER CENTER SUPPORT GRANT

STRUCTURAL BIOLOGY CENTER FOR HIV/HOST INTERACTIONS IN TRAFFICKING AND ASSEMBLY

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

UTAH TRIAL INNOVATION CENTER

CENTRAL DATA MANAGEMENT AND COORDINATING CENTER

ROCKY MOUNTAIN CENTER FOR OCCUPATIONAL AND ENVIRONMENTAL HEALTH

PROSPECTIVE RESEARCH STUDIES OF MATURATION (PRISM)- RESEARCH PROJECT

CHEETAH CENTER FOR THE STRUCTURAL BIOLOGY OF HIV INFECTION, RESTRICTION, AND VIRAL DYNAMICS - PROGRAM SUMMARY THE CHEETAH CENTER FOR THE STRUCTURAL BIOLOGY OF HIV INFECTION, RESTRICTION, AND VIRAL DYNAMICS WILL BE ORGANIZED AROUND: 1) THREE SCIENTIFIC PROJECTS THAT WILL ADVANCE OUR UNDERSTANDING OF HIV-HOST INTERACTIONS AND PROVIDE THE FOUNDATIONS FOR DEVELOPING NEW THERAPEUTIC STRATEGIES FOR HIV TREATMENT AND CURE, 2) THREE SCIENTIFIC CORES THAT WILL ADVANCE IMPORTANT METHODOLOGY AND PROVIDE CENTER MEMBERS WITH ACCESS TO STATE-OF-THE-ART TECHNOLOGIES, 3) AN ADMINISTRATIVE CORE THAT WILL COORDINATE CENTER ACTIVITIES AND DIRECT OUR SCIENTIFIC EDUCATION, PUBLIC OUTREACH, AND MOLECULAR ANIMATIONS, AND 4) A DEVELOPMENTAL CORE THAT WILL ENGAGE AND SUPPORT THE NEXT GENERATION OF HIV STRUCTURAL BIOLOGY RESEARCHERS. SCIENTIFIC PROJECT 1 (INFECTING THE CELL) WILL DEFINE THE STEPS IN THE FIRST HALF OF THE HIV-1 LIFE CYCLE IN MOLECULAR AND MECHANISTIC DETAIL. SCIENTIFIC PROJECT 2 (INNATE CELLULAR DEFENSES AGAINST HIV) WILL DEFINE THE STRUCTURAL AND MECHANISTIC BASES FOR HOST RECOGNITION, RESTRICTION, AND INNATE IMMUNE RESPONSES TO HIV-1. SCIENTIFIC PROJECT 3 (MULTISCALE ANALYSIS AND MODULATION OF VIRAL DYNAMICS) WILL CHARACTERIZE AND MODULATE HIV-1 DYNAMICS ACROSS MULTIPLE SIZE AND RESOLUTION SCALES; FROM WHOLE-ANIMAL STUDIES THAT WILL IMAGE AND CHARACTERIZE SITES OF VIRAL REBOUND AT THE CELLULAR AND TISSUE LEVELS, TO STRUCTURAL STUDIES OF PROVIRAL SILENCING AND REACTIVATION, TO STUDIES THAT ATTEMPT TO CREATE NEW PANTROPIC BLOCKS TO ENVELOPED VIRUS BUDDING AND NEW BIOLOGICS DELIVERY SYSTEMS. SCIENTIFIC CORE 1 (TOOLS FOR BIOPOLYMER SYNTHESIS AND SCREENING) WILL DEVELOP NEW METHODOLOGY AND PROVIDE CENTER MEMBERS WITH ACCESS TO STATE-OF-THE-ART INSTRUMENTATION AND EXPERTISE IN PEPTIDE SYNTHESIS, PROTEIN DESIGN, AND CRISPR SCREENING METHODOLOGY. SCIENTIFIC CORE 2 (TOOLS FOR STRUCTURAL AND MECHANISTIC STUDIES) WILL DEVELOP NEW METHODOLOGY AND PROVIDE CENTER MEMBERS WITH ACCESS TO STATE-OF-THE-ART INSTRUMENTATION AND EXPERTISE IN FLUORESCENCE SPECTROSCOPY AND DYNAMICS, SCAFFOLDS FOR STRUCTURE DETERMINATION, AND ELECTRON CRYOTOMOGRAPHY. SCIENTIFIC CORE 3 (PROTEIN PRODUCTION, BIOPHYSICAL CHARACTERIZATION, AND STRUCTURE DETERMINATION) WILL PROVIDE ACCESS TO STATE-OF-THE-ART INSTRUMENTATION AND EXPERTISE IN EXPRESSION AND PURIFICATION OF PROTEINS AND COMPLEXES, BIOPHYSICAL CHARACTERIZATION, AND STRUCTURE DETERMINATION BY BOTH X-RAY CRYSTALLOGRAPHY AND CRYOEM. OUR ADMINISTRATIVE CORE WILL COORDINATE THE ENTIRE RANGE OF CENTER ACTIVITIES; MONITORING PROGRESS, AND ENSURING THAT ALL PERSONNEL, PROJECTS, AND CORES ARE FUNCTIONING EFFECTIVELY. THIS CORE WILL ALSO OVERSEE CENTER ORGANIZATION AND GOVERNANCE, AND SCIENTIFIC EDUCATION AND PUBLIC OUTREACH, INCLUDING OUR AWARD-WINNING SCIENCE OF HIV WEBSITE AND ASSOCIATED MEDIA. OUR DEVELOPMENTAL CORE WILL ADMINISTER OUR COLLABORATIVE DEVELOPMENT, SEMINAR, VISITING SCHOLAR, AND OTHER TRAINING ACTIVITIES FOR EARLY CAREER INVESTIGATORS.

UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE

EMSC DATA CENTER

CTSA UM1 PROGRAM AT UNIVERSITY OF UTAH - ABSTRACT THE VISION OF THE UTAH CLINICAL & TRANSLATIONAL SCIENCE INSTITUTE (CTSI) IS TO STRATEGICALLY AND ETHICALLY DEVELOP AND APPLY GENERALIZABLE AND REPRODUCIBLE CLINICAL AND TRANSLATIONAL SCIENCE (CTS) INNOVATIONS TO INCREASE SCIENCE EQUITY AND HEALTH EQUITY, AND PROMOTE SOCIAL JUSTICE. THE UTAH CTSI COLLABORATES WITH LOCAL, REGIONAL, AND NATIONAL PARTNERS AND COLLABORATORS TO ACHIEVE THIS VISION THROUGH FOUR SPECIFIC AIMS: (1) SERVE AS A WELL-RECOGNIZED HUB FOR CLINICAL AND TRANSLATIONAL SCIENCE THAT PROMOTES SCIENCE AND HEALTH EQUITY IN A MEASURABLE, REPRODUCIBLE, AND SUSTAINABLE MANNER. (2) DESIGN, DEVELOP, AND TEST INNOVATIVE TRANSLATIONAL SCIENCE METHODS, TOOLS, TECHNIQUES, AND BEST PRACTICES TO INCREASE EFFICIENCY AND REPRODUCIBILITY. (3) SUPPORT THE IMPLEMENTATION AND DISSEMINATION OF TRANSLATIONAL SCIENCE INNOVATIONS AND THE EDUCATION AND DEVELOPMENT OF THE TRANSLATIONAL SCIENCE AND RESEARCH WORKFORCE. (4) CATALYZE THE ADVANCEMENT OF TRANSLATIONAL RESEARCH DISCOVERIES FROM BENCH TO BEDSIDE TO POPULATIONS TO IMPROVE THE HEALTH OF INDIVIDUALS AND COMMUNITIES, REDUCING HEALTH DISPARITIES AND IMPROVING HEALTH EQUITY. THROUGH COMPREHENSIVE AND INTEGRATED WORKFORCE DEVELOPMENT PROGRAMS, WE WILL TRAIN THE NEXT GENERATION OF DIVERSE CLINICIANS, BENCH SCIENTISTS, INFORMATICIANS, AND HEALTH SERVICE SCIENTISTS IN THE TRANSLATIONAL, ETHICAL, AND TEAM SCIENCE ASPECTS OF MODERN BIOMEDICAL RESEARCH. WE WILL CREATE A NOVEL MODEL AND ECOSYSTEM FOR ENGAGING STAKEHOLDERS WHO EXPERIENCE HEALTH DISPARITIES, INCLUDING UNDERSERVED RACIAL/ETHNIC POPULATIONS, SENIOR CITIZENS, MEMBERS OF LGBTQ+ COMMUNITIES, AND RURAL/FRONTIER RESIDENTS ACROSS THE INTERMOUNTAIN WEST, IN ORDER TO: ENSURE THAT MANY VOICES ARE HEARD THROUGHOUT THE RESEARCH LIFE CYCLE; (POTENTIAL) RESEARCH PARTICIPANTS ARE INFORMED, ENGAGED, AND SUPPORTED SO THAT PARTICIPATION IS ACCESSIBLE TO ALL; AND FINDINGS ARE TRANSLATED INTO CARE THAT SUPPORTS HEALTH EQUITY. THROUGH OUR RESOURCES AND SERVICES, WE WILL PROVIDE STAKEHOLDER ENGAGEMENT, STUDY DESIGN AND ANALYSIS, INFORMATICS, ETHICS, AND CLINICAL RESEARCH INFRASTRUCTURE TO THE UTAH CTSI COMMUNITY (INCLUDING PATIENTS, COMMUNITY MEMBERS, INVESTIGATORS, AND PROVIDERS). OUR TRANSLATIONAL INNOVATION PILOT PROGRAM WILL LAUNCH NOVEL PROJECTS TO ADDRESS GENERALIZABLE TRANSLATIONAL SCIENCE QUESTIONS, OVERCOMING BARRIERS TO ACCELERATE TRANSLATIONAL RESEARCH. WE WILL LEVERAGE MODERN INFORMATICS TECHNIQUES TO INTEGRATE CLINICAL DATA WITH SOCIAL DETERMINANTS OF HEALTH AND ENVIRONMENTAL DATA IN AN EASILY ACCESSIBLE FORMAT TO FACILITATE QUANTITATIVE STUDIES SEEKING TO UNDERSTAND HOW THESE FACTORS CONTRIBUTE TO HEALTH DISPARITIES. OUR CTS RESEARCH PROGRAM WILL CONDUCT A SERIES OF PROJECTS TO IMPROVE INCLUSIVENESS ACROSS THE TRANSLATIONAL RESEARCH LIFECYCLE. OUR STRATEGIC MANAGEMENT TEAM BRINGS TOGETHER EXPERIENCED LEADERS FROM ACROSS THE INSTITUTION, PARTNERS, AND COLLABORATORS TO UNIFY OUR EFFORTS, AND ENSURE EFFICIENT ADMINISTRATION AND IMPLEMENTATION OF THE UTAH CTSI'S AIMS. OUR HUB LIAISON TEAM WILL ENSURE THAT WE HAVE ACTIVE, DIVERSE PARTNER PARTICIPATION IN NATIONAL NCATS AND CTSA EFFORTS, AND PROMOTE DISSEMINATION OF CTS INNOVATIONS ACROSS HUBS.

THE UQ-PREDICTIVE MULTIDISCIPLINARY SIMULATION CENTER FOR HIGH EFFICIENCY ELECTRIC POWER GENERATION WITH CARBON CAPTURE

CONUS PEPTIDES AND THEIR RECEPTOR TARGETS

EMERGENCY MEDICAL SERVICE FOR CHILDREN NETWORK DEVELOPMENT

UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE-UL1

NSF CENTER FOR SYNTHETIC ORGANIC ELECTROCHEMISTRY

UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE

MULTISCALE MULTIDISCIPLINARY MODELING OF ELECTRONIC MATERIALS (MSME) COLLABORATIVE RESEARCH ALLIANCE (CRA)

HIGHER EDUCATION SYSTEM STRENGTHENING ACTIVITY (HESSA)

TRANSDISCIPLINARY TEAM SCIENCE IN COLORECTAL CANCER PROGNOSIS: THE COLOCARE STUDY

GREATER INTERMOUNTAIN NODE

VALUE-BASED MEDICAL STUDENT EDUCATION TRAINING PROGRAM

A PHASE-2B, DOUBLE-BLIND, RANDOMIZED CONTROLLED TRIAL TO EVALUATE THE ACTIVITY AND SAFETY OF INEBILIZUMAB IN ANTI-N-METHYL-D-ASPARTATE RECEPTOR (NMDAR) ENCEPHALITIS AND ASSESS MARKERS OF DISEASE - N-METHYL-D-ASPARTATE RECEPTOR (NMDAR) ENCEPHALITIS IS ONE OF THE MOST COMMON CAUSES OF AUTOIMMUNE ENCEPHALITIS, WITH PREVALENCE EXCEEDING HERPES ENCEPHALITIS IN INDUSTRIALIZED NATIONS. TYPICALLY, THE DISEASE AFFECTS PATIENTS AGE 10-50 CAUSING PROMINENT PSYCHIATRIC SYMPTOMS, ASSOCIATED WITH DECLINING CONSCIOUSNESS, SEIZURES, MOVEMENT DISORDERS AND LIFE-THREATENING DYSAUTONOMIA. INTENSIVE CARE, INCLUDING CARDIORESPIRATORY SUPPORT IS REQUIRED IN 75% OF CASES. THE DIAGNOSIS IS CONFIRMED BY DETECTION OF IGG AUTOANTIBODIES AGAINST CENTRAL NERVOUS SYSTEM NMDAR IN THE CEREBROSPINAL FLUID. DESPITE THE SEVERITY OF THE ILLNESS, NMDAR ENCEPHALITIS IS A TREATABLE NEUROLOGICAL DISEASE, WITH RETROSPECTIVE CASE SERIES ESTABLISHING THE BENEFIT OF OFF- LABEL INTRAVENOUS STEROIDS AND IMMUNOGLOBULINS. THESE TREATMENTS ARE PRESUMED TO WORK THROUGH EFFECTS ON IGG NMDAR AUTOANTIBODY LEVELS IN THE CSF, ALTHOUGH PROSPECTIVE DATA INFORMING PREDICTORS OF TREATMENT RESPONSES ARE LIMITED. EVEN WITH PROMPT TREATMENT, ~50% OF PATIENTS REMAIN DISABLED, REQUIRING PROLONGED HOSPITAL ADMISSIONS. VARIOUS OFF-LABEL THERAPIES HAVE BEEN PROPOSED AS “SECOND-LINE” TREATMENTS IN NMDAR ENCEPHALITIS. THE MAJORITY OF SECOND-LINE TREATMENTS TARGET CIRCULATING B-CELLS WITH VARIOUS DEGREES OF BLOOD BRAIN PENETRANCE AND EFFICACY, AND POOR CONSENSUS ON THE TIMING, DOSE AND ROUTE OF DELIVERY OF CANDIDATE AGENTS. HIGH-QUALITY EVIDENCE IS NEEDED TO INFORM THE TREATMENT OF NMDAR ENCEPHALITIS. INEBILIZUMAB IS A PROMISING THERAPEUTIC MONOCLONAL ANTIBODY FOR THE TREATMENT OF NMDAR ENCEPHALITIS. THIS HUMANIZED MONOCLONAL ANTIBODY AGAINST THE B-CELL SURFACE ANTIGEN CD19 WAS RECENTLY SHOWN TO BE SAFE AND EFFICACIOUS IN THE TREATMENT OF NEUROMYELITIS OPTICA SPECTRUM DISORDER—ANOTHER ANTIBODY-MEDIATED DISORDER OF THE CENTRAL NERVOUS SYSTEM. COMPARED TO OTHER OFF LABEL B-CELL DEPLETING THERAPIES, SUCH AS RITUXIMAB, INEBILIZUMAB NOT ONLY DEPLETES CD20+ B-CELLS, BUT ALSO CD20- PLASMA BLASTS AND PLASMA CELLS, RESULTING IN ROBUST, BROAD AND SUSTAINED SUPPRESSION OF B-CELL EXPRESSION. THE EXTINGUISH TRIAL WILL RANDOMIZE 116 PARTICIPANTS WITH MODERATE-TO-SEVERE NMDAR ENCEPHALITIS TO RECEIVE EITHER INEBILIZUMAB OR PLACEBO IN ADDITION TO FIRST-LINE THERAPIES. PATIENT OUTCOMES WILL BE ASCERTAINED AT STANDARD INTERVALS USING THE MODIFIED RANKIN SCALE AND ACCEPTED SAFETY MEASURES (PRIMARY OUTCOMES AT 16 WEEKS), TOGETHER WITH COMPREHENSIVE WELL-VALIDATED NEUROPSYCHOLOGICAL TESTS, BEDSIDE COGNITIVE SCREENING TOOLS, QUALITY OF LIFE/ FUNCTIONAL INDICES, AND OUTCOME PREDICTION MEASURES. CLINICAL DATA WILL BE COMBINED WITH QUANTITATIVE MEASURES OF NMDAR AUTOANTIBODY TITERS AND CYTOKINES IMPLICATED IN B-CELL ACTIVATION AND ANTIBODY PRODUCTION WITHIN THE INTRATHECAL COMPARTMENT TO IDENTIFY TREATMENT RESPONDERS, INFORM THE BIOLOGIC CONTRIBUTORS TO OUTCOMES, AND EVALUATE FOR BIOMARKERS THAT MAY SERVE AS EARLY PREDICTORS OF FAVORABLE OUTCOMES IN FUTURE CLINICAL TRIALS IN NMDAR ENCEPHALITIS. THE RESULTS OF THE EXTINGUISH TRIAL WILL IMMEDIATELY IMPACT PATIENT CARE AND WILL FACILITATE THE DESIGN AND IMPLEMENTATION OF FUTURE CLINICAL TRIALS IN PATIENTS WITH AUTOIMMUNE ENCEPHALITIS.

EARLY LIFE EXPOSURES AND CHILD TRAJECTORIES: GROWTH AND RESPIRATORY HEALTH

CENTER FOR THE STRUCTURAL BIOLOGY OF CELLULAR HOST ELEMENTS IN EGRESS, TRAFFICKING, AND ASSEMBLY OF HIV (CHEETAH CENTER)

UNIVERSITY OF UTAH BIOMEDICAL INFORMATICS TRAINING

PEDIATRIC CRITICAL CARE SCIENTIST DEVELOPMENT PROGRAM

HEAL ERN: DATA COORDINATING RESOURCE CENTER - PROJECT SUMMARY THE NIH CREATED THE HELPING TO END ADDICTION LONG-TERM (HEAL) INITIATIVE TO SPEED SCIENTIC SOLUTIONS TO THE NATIONAL OPIOID PUBLIC HEALTH CRISIS. AS PART OF THE HEAL INITIATIVE, THE HEAL EFFECTIVENESS RESEARCH NETWORK (ERN) WAS ESTABLISHED TO CONDUCT COMPARATIVE EFFECTIVENESS TRIALS FOR PREVENTION AND MANAGEMENT OF PAIN, WHILE REDUCING RISK OF ADDICTION. FIVE ERN TRIALS HAVE BEEN IMPLEMENTED WITH DATA COORDINATION SUPPORT FROM THE UNIVERSITY OF UTAH TRIAL INNOVATION CENTER. THIS PROPOSAL IS WRITTEN IN RESPONSE TO RFA-TR-22-012 TO PROVIDE CONTINUED SUPPORT FOR THESE VE TRIALS, AS WELL AS TWO ADDITIONAL TRIALS THAT MAY BE FUNDED IN RESPONSE TO RFA-AT-22- 005 (“HEAL INITIATIVE: SICKLE CELL DISEASE PAIN MANAGEMENT TRIALS UTILIZING THE PAIN MANAGEMENT EFFECTIVENESS RESEARCH NETWORK COOPERATIVE AGREEMENT”). THE UNIVERSITY OF UTAH IS RESPONDING TO BE THE DATA COORDINATION RESOURCE CENTER (DCRC). WE WILL CONTINUE TO WORK COLLABORATIVELY WITH EACH ERN STUDY TEAM AND THE OTHER HEAL ERN RESOURCE CENTERS TO 1) DEVELOP, IMPLEMENTAND MONITOR THE ERN TRIALS; 2) HELP RESPOND TO ISSUES/PROTOCOL CHANGES THAT EMERGE DURING TRIAL IMPLEMENTATION AND INITIATE TIMELY NECESSARY CHANGES TO ASSURE TRIAL SUCCESS; 3) PROVIDE COLLECTION AND ANALYSIS OF DATA; AND 4) ASSIST WITH TIMELY PUBLICATION OF STUDY RESULTS. OUR APPLICATION HAS THREE SPECIC AIMS: 1. WORK WITH ERN INVESTIGATORS AND OTHER HEAL ERN RESOURCE CENTERS TO PROVIDE COLLABORATIVE CLINICAL TRIAL EXPERTISE AND ASSISTANCE IN STUDY AND PROTOCOL DESIGN, SINGLE IRB, STUDY IMPLEMENTATION AND MANAGEMENT, ACCRUAL OF SUBJECTS, INTERIM STUDY REPORTING, NAL STUDY ANALYSES, AND ASSISTANCE WITH TIMELY PUBLICATION AND DISSEMINATION OF STUDY RESULTS. 2. PROVIDE COMPREHENSIVE DATA MANAGE- MENT FOR CURRENT AND NEW ERN TRIALS, INCLUDING DATABASE AND DATA COLLECTION SYSTEMS, DATA MANAGEMENT PLANS, DATA RISK ASSESSMENT AND QUALITY CONTROL, IMPLEMENTATION OF RANDOMIZATION, ASSISTANCE WITH DATA SAFETY MONITOR- ING BOARD (DSMB) REPORTS, AND TRAINING FOR USING THE DATA COLLECTION SYSTEMS. 3. FACILITATE SHARING OF DATA FROM HEAL/ERN TRIALS BY INCORPORATING HEAL COMMON DATA ELEMENTS(CDES) INTO PROTOCOLS, CONTINUING TO SUPPORT NIH PROGRAM STAFF IN DEVELOPMENT OF HEAL CDES, CONTINUED PARTICIPATION IN THE HEAL COLLECTIVE BOARD, AND PREPARATION OF NAL DATA SETS SUITABLE FOR DEPOSIT IN NIH-DESIGNATED REPOSITORIES FOR INCORPORATION INTO THE HEAL DATA ECOSYSTEM. OUR COLLABORATION WITH ERN INVESTIGATORS AND INTEGRATION WITH THE OTHER RESOURCE CENTERS WILL MAXIMIZE THE LIKELIHOOD OF SUCCESSFUL AND TIMELY COMPLETION OF THE HEAL ERN CLINICAL TRIALS, LEADING TO TRANSLATION OF RESEARCH NDINGS TO THE EFFECTIVE MANAGEMENT OF ACUTE AND CHRONIC PAIN, WHILE MINIMIZING ADDICTIVE OPIOID DOSING REGI- MENS.

TAS::89 0211::TAS RECOVERY SITE CHARACTERIZATION FOR NEW AWARD ENTITLED, "RECOVERY ACT: CHARACTERIZATION OF MOST PROMISING SEQUESTRATION FORMATIONS I

CONCEPT TESTING AND DEVELOPMENT AT THE RAFT RIVER GEOTHERMAL FIELD, IDAHO

MOLECULAR/CLINICAL APPROACHES TO COLON CANCER PRECURSORS

RECOVERY ACT - UTAH ANCHORS: A COMMUNITY BROADBAND PROJECT

CLEAN AND SECURE ENERGY FROM COAL

REPROGRAMMED PLATELETS: EFFECTORS OF THROMBOSIS IN METABOLIC SYNDROMES

VALUE-BASED MEDICAL STUDENT EDUCATION TRAINING PROGRAM

COLLABORATIVE PEDIATRIC CRITICAL CARE RESEARCH NETWORK - PROJECT SUMMARY IN 2005, THE EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT (NICHD) ESTABLISHED THE COLLABORATIVE PEDIATRIC CRITICAL CARE RESEARCH NETWORK (CPCCRN) TO SUPPORT MULTI-INSTITUTIONAL RANDOMIZED CONTROLLED TRIALS (RCTS) AND OBSERVATIONAL STUDIES IN CRITICALLY ILL CHILDREN. THIS PL1 PROPOSAL FROM THE UNIVERSITY OF UTAH IS SUBMITTED ON BEHALF OF A NEWLY CONGURED CPCCRN NETWORK INCREASED TO 12 CLINICAL SITES AND 12 ANCILLARY SITES WITH > 61,000 ANNUAL ICU ADMISSIONS. THE EXPANDED NETWORK HAS GEOGRAPHIC, RACIAL/ETHNIC AND SOCIOECONOMIC DIVERSITY, AND WILL BE A PLATFORM TO DEVELOP ADDITIONAL INVESTIGATORS, ESPECIALLY YOUNG CLINICIAN SCIENTISTS. THE NETWORK WILL CONDUCT A HIGHLY INNOVATIVE LARGE-SCALE MULTI-CENTER STUDY OF PERSONALIZED, TARGETED IMMUNE MODULATION IN CHILDREN WITH SEPSIS-INDUCED MULTIPLE ORGAN DYSFUNCTION SYNDROME (MODS). THE STUDY INCLUDES TWO CONCURRENT, IMMUNOPHENOTYPE-DRIVEN PLACEBO CONTROLLED RCTS THAT WILL ADDRESS THE CENTRAL HYPOTH- ESIS THAT INDIVIDUALIZED, PATHOPHYSIOLOGY-SPECIC IMMUNOMODULATION WILL IMPROVE OUTCOMES FROM SEPSIS-INDUCED MODS IN CHILDREN. THIS STUDY BUILDS ON R01-FUNDED CPCCRN STUDIES THAT HAVE DEMONSTRATED THE EXISTENCE OF SPECIC IMMUNE PHENOTYPES AMONG CHILDREN WITH SEPSIS-INDUCED MODS (R01GM108618 PI: CARCILLO) AND SUC- CESSFUL REVERSAL OF IMMUNOSUPPRESSION BY ADMINISTRATION OF THE IMMUNOSTIMULANT GRANULOCYTE MACROPHAGE-COLONY STIMULATING FACTOR (GM-CSF) (R01GM094203 PI: HALL). IT ALSO COMPLEMENTS THE ONGOING NICHD R01-FUNDED STUDY INVESTIGATING THE RISK FACTORS FOR IMMUNOPARALYSIS IN PEDIATRIC MODS (R01HD095976 MPI: HALL, ZUPPA). THIS APPLICATION HAS THREE SPECIC AIMS: (1) IMPLEMENT THE CPCCRN ORGANIZATION; (2) MOUNT A COMPREHEN- SIVE STRATEGY FOR DEVELOPMENT OF YOUNG CLINICIAN SCIENTISTS AND SUBMISSION OF RIGOROUS PROPOSALS TO FUND ADDITIONAL RESEARCH IN CRITICAL CARE; (3) CONDUCT THE PERSONALIZED IMMUNOMODULATION IN SEPSIS-INDUCED MODS STUDY. THE RST TRIAL FOCUSES ON THE USE OF THE DRUG GM-CSF FOR THE REVERSAL OF IMMUNOPARALYSIS. THE SECOND TRIAL USES ADAPTIVE RANDOMIZATION AND FOCUSES ON THE DRUGS ANAKINRA AND TOCILIZUMAB FOR THE TARGETED TREATMENT OF HYPER- INAMMATION. THE PRIMARY OUTCOME OF BOTH TRIALS WILL BE DURATION AND SEVERITY OF ORGAN DYSFUNCTION USING THE CUMULATIVE PELOD-2 SCORE, AND SECONDARY OUTCOMES WILL ASSESS HEALTH RELATED QUALITY OF LIFE AND FAMILY FUNCTION- ING AT 3 AND 12 MONTHS. THE PERSONALIZED IMMUNOMODULATION IN SEPSIS-INDUCED MODS STUDY REPRESENTS A PARADIGM SHIFT IN THE MAN- AGEMENT OF PEDIATRIC SEPSIS, NALLY MOVING BEYOND SIMPLE SUPPORTIVE CARE. WE ARE UNIQUELY POSITIONED TO SUC- CESSFULLY EXECUTE THIS APPROACH TO PERSONALIZED, REAL-TIME, PATHOPHYSIOLOGY-DIRECTED SEPSIS TREATMENT, LEVERAGING THE STRENGTHS OF A DIVERSE AND HIGHLY ACCOMPLISHED GROUP OF INVESTIGATORS TO DELIVER HIGH-IMPACT SCIENCE TO THE BENET OF OUR PATIENTS AND OUR ELD.

NEXT-GENERATION MATERIALS FOR PLASMONICS AND SPINTRONICS

TARGETING SS18-SSX BIOLOGY IN SYNOVIAL SARCOMAGENESIS

BIO-INSPIRED DESIGN OF ADAPTIVE CATALYSIS CASCADES

CORE VISION RESEARCH GRANT

PDX TRIAL CENTER FOR BREAST CANCER THERAPY

REGION 4, REGIONAL MEDICAL LIBRARY AND NETWORK OF THE NATIONAL LIBRARY OF MEDICINE TRAINING OFFICE - REGION 4 OVERALL - PROJECT SUMMARY THE SPENCER S. ECCLES HEALTH SCIENCES LIBRARY (EHSL), UNIVERSITY OF UTAH, AS THE REGIONAL MEDICAL LIBRARY (RML) FOR REGION 4, WILL IMPLEMENT REGIONAL AND NATIONAL PROGRAMS IN SUPPORT OF THE MISSION OF THE NETWORK OF THE NATIONAL LIBRARY OF MEDICINE (NNLM) TO PROVIDE U.S. RESEARCHERS, HEALTH PROFESSIONALS, PUBLIC HEALTH WORKFORCE, EDUCATORS, AND THE PUBLIC WITH EQUAL ACCESS TO BIOMEDICAL AND HEALTH INFORMATION RESOURCES AND DATA. THIS WILL INCLUDE TRAINING, FUNDING, AND ENGAGEMENT OPPORTUNITIES FOR MEMBER LIBRARIES AND OTHER ORGANIZATIONS TO CARRY OUT REGIONAL AND NATIONAL PROGRAMS. REGION 4 WILL ASSESS AND INTERPRET THE NEEDS OF CURRENT AND POTENTIAL AUDIENCES TO EXPAND THE REACH AND IMPACT OF THE NATIONAL LIBRARY OF MEDICINE (NLM). REGION 4 WILL WORK WITH THE OTHER RMLS, OFFICES, CENTERS AND THE NNLM EVALUATION CENTER TO COOPERATIVELY DESIGN, IMPLEMENT, AND EVALUATE INNOVATIVE APPROACHES TO SERVING THE BIOMEDICAL AND HEALTH INFORMATION NEEDS OF RESEARCHERS, HEALTH PROFESSIONALS, PUBLIC HEALTH WORKFORCE, EDUCATORS, AND THE PUBLIC IN COMMUNITIES ACROSS THE U.S., SO THAT ALL COMMUNITIES HAVE EQUAL ACCESS TO THE HIGHEST LEVEL OF HEALTH INFORMATION REGARDLESS OF DEMOGRAPHICS. THE NINE STATES OF REGION 4 HAVE A NUMBER OF COMMONALITIES INCLUDING LARGE RURAL AREAS WITH FEW CITIES, NATIVE AMERICAN RESERVATIONS AND TRIBAL UNIVERSITIES AND COLLEGES, EXTENSIVE AREAS LACKING INTERNET SERVICE, BORDER REGIONS TO THE NORTH WITH CANADA AND TO THE SOUTH WITH MEXICO, MANY MEDICALLY UNDERSERVED COMMUNITIES AND INDIVIDUALS (MUC/I), AND RURAL HOSPITALS AND CLINICS. OUR FOCUS ON ENGAGING WITH LIBRARIES AND OTHER ORGANIZATIONS SUCH AS PUBLIC HEALTH ENTITIES AND COMMUNITY-BASED ORGANIZATIONS, AS WELL AS ESTABLISHING TWO-WAY COMMUNICATIONS THROUGHOUT REGION 4, WILL ENABLE INCREASED OUTREACH, EDUCATION, AND FUNDING DESIGNED TO IMPROVE ACCESS TO RELIABLE HEALTH INFORMATION AND DATA. CENTRALLY LOCATED WITHIN REGION 4, THE EHSL, AS PART OF THE UNIVERSITY OF UTAH (UU), IS UNIQUELY POSITIONED TO ENGAGE SUCCESSFULLY IN THE WORK DESCRIBED. AS PART OF THE UU COMMUNITY, WE WILL LEVERAGE THE AFFILIATIONS WITH OUR HOSPITALS, CLINICS, SCHOOLS, COLLEGES, DIVERSITY OFFICERS, AND TEACHING AND LEARNING SPECIALISTS TO ENHANCE THE SUCCESS OF OUR PROGRAMS NATIONWIDE. WE BELIEVE THAT TRUST IN NLM, NNLM, AND RML PRODUCTS AND SERVICES CAN ONLY BE ACHIEVED WHEN THE COMMUNITIES SERVED HAVE AN AUTHENTIC AND LEGITIMATE VOICE IN HOW THESE SERVICES ARE ADMINISTERED. OUR PROPOSAL DEMONSTRATES A SUSTAINABLE PLAN TO LISTEN TO AND PARTNER WITH CURRENT AND FUTURE AUDIENCES THROUGHOUT REGION 4 AND THE NATION TO INCREASE ACCESS TO RELIABLE HEALTH INFORMATION AND IMPROVE HEALTH EQUITY.

FORECASTING AND SURVEILLANCE OF INFECTIOUS THREATS AND EPIDEMICS (FORESITE)

CLOUDLAB: FLEXIBLE SCIENTIFIC INFRASTRUCTURE TO SUPPORT FUNDAMENTAL ADVANCES IN CLOUD ARCHITECTURES AND APPLICATIONS

NATIONAL NETWORK OF LIBRARIES OF MEDICINE MIDCONTINENTAL (REGION 4) AND NATIONAL TRAINING OFFICE

INTRACELLULAR SIGNALING BY BACTERIAL CHEMORECEPTOS

CLOUDLAB PHASE III: EXPANDING THE FRONTIERS OF CLOUD COMPUTING THROUGH WORLD-CLASS COMMUNITY INFRASTRUCTURE

MULTI-SCALE FLUID-SOLID INTERACTIONS IN ARCHITECTED AND NATURAL MATERIALS (MUSE)

TAS::89 0240::TAS CO2 - PREDICITIVITY OF CARBON MANAGEMENT

NOVEL STRATEGIES FOR ACCELERATING NON-OPIOID DRUG DISCOVERY

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

CENTER FOR INTEGRATIVE BIOMEDICAL COMPUTING

PARTNER CENTER FOR ADVANCED STUDIES IN WATER (PCASW)

CLOUDLAB PHASE II: COMMUNITY INFRASTRUCTURE TO EXPAND THE FRONTIERS OF CLOUD COMPUTING RESEARCH

EARLY LIFE EXPOSURES AND CHILD TRAJECTORIES: GROWTH AND RESPIRATORY HEALTH

CLOUDLAB PHASE-IV: STRENGTHENING A CORE RESOURCE FOR RESEARCH AND EDUCATION -CLOUD TECHNOLOGIES UNDERPIN MANY OF THE APPS AND COMPUTING SERVICES THAT WE USE EVERY DAY, INCLUDING SOCIAL NETWORKING, ONLINE COMMERCE, EMAIL, VIDEO CONFERENCING, AND MANY MORE. TO BE ABLE TO DO RESEARCH THAT DRIVES FORWARD THE FUNDAMENTAL ARCHITECTURE OF THE CLOUD, SCIENTISTS NEED AN ENVIRONMENT IN WHICH THEY CAN EXPERIMENT WITH THE PRIMARY BUILDING BLOCKS OF THE CLOUD: COMPUTE POWER, STORAGE, AND NETWORKS. CLOUDLAB PROVIDES AN ENVIRONMENT WHERE RESEARCHERS CAN BUILD THEIR OWN CLOUDS, OBSERVING AND CHANGING HOW THEY OPERATE ALL THE WAY TO THE BOTTOM LAYERS OF SOFTWARE. CLOUDLAB IS A LARGE FACILITY, CONSISTING, AS OF THE START OF THIS AWARD, OF MORE THAN 1,800 SERVERS HOSTED AT THE UNIVERSITY OF UTAH, CLEMSON UNIVERSITY, AND THE UNIVERSITY OF WISCONSIN-MADISON. THESE SERVERS INCLUDE CUTTING-EDGE COMPUTE (SUCH AS SEVERAL DIFFERENT PROCESSOR ARCHITECTURES, GRAPHICS PROCESSING UNITS, AND FIELD PROGRAMMABLE GATE ARRAYS), NETWORKING (OPENFLOW, USER-PROGRAMMABLE SWITCHING), AND STORAGE (HARD DRIVES, SOLID STATE DRIVES) TECHNOLOGIES. THIS PHASE IV AWARD WILL SUPPORT THE EXPANSION OF THIS FACILITY BY SEVERAL HUNDRED SERVERS TO MEET HIGH DEMAND. IT WILL ALSO ADD NEW TECHNOLOGIES, SUCH AS INTERNET OF THINGS DEVICES, PROGRAMMABLE NETWORK CARDS, AND NON-VOLATILE RANDOM ACCESS MEMORY, WHICH WILL IN TURN SUPPORT RESEARCH ON DATA-INTENSIVE COMPUTING AND COMPUTING AT THE EDGE OF THE NETWORK. CLOUDLAB IS AVAILABLE TO RESEARCHERS WHO WORK ON THE FUNDAMENTALS OF CLOUD COMPUTING. THESE USERS DO RESEARCH IN AREAS SUCH AS NETWORKING, SECURITY, AND DATABASES; IN TURN, THIS WORK HAS BROAD IMPACT, AS THESE ARE THE FUNDAMENTAL TECHNOLOGIES UPON WHICH WE BUILD THINGS SUCH AS SMART CITIES, TELEHEALTH, ONLINE EDUCATION, AND OTHER SOCIALLY IMPORTANT COMPUTER SERVICES. BECAUSE IT IS OFFERED AT NO COST FOR RESEARCH AND EDUCATION TO ACADEMIC USERS, IT ACTS AS A LEVEL PLAYING FIELD ON WHICH INSTITUTIONS LARGE AND SMALL, AND THOSE WITH MANY RESOURCES AND THOSE WITH FEW, CAN CONDUCT WORK ON AN EQUAL FOOTING. CLOUDLAB CAN BE FOUND ONLINE AT HTTPS://CLOUDLAB.US/, WHICH IS THE PRIMARY INTERFACE THROUGH WHICH RESEARCH USERS INTERACT WITH THE FACILITY, MAKING IT ACCESSIBLE FROM ANYWHERE. THIS AWARD WILL SUPPORT CONTINUED OPERATION OF THE FACILITY, INCLUDING THE AFOREMENTIONED HARDWARE EXPANSION, DEVELOPMENT OF NEW FEATURES, AND USER SUPPORT. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

DEVELOPMENT OF COMPLEMENT MODULATING THERAPEUTICS FOR AMD

TRAINING LONG TERM - LEND NEURODEVELOPMENTAL DISABILITIES

NEW AWARD TITLED CLEAN AND SECURE ENERGY FROM DOMESTIC OIL SHALE AND OIL SANDS RESOURCES WITH THE UNIVERSITY OF UTAH - FY09 CDP - SCNGO

ENDOSCOPIC VERSUS SHUNT TREATMENT OF HYDROCEPHALUS IN INFANTS

PREVENTION OF LETHAL METASTATIC BREAST CANCER BY IDENTIFYING AND ERADICATING CLINICALLY RELEVANT DISSEMINATED TUMOR CELLS

GENOME-WIDE ANALYSIS OF CARDIAC DEVELOPMENT IN ZEBRAFISH

UINTA BASIN CARBONSAFE II: STORAGE COMPLEX FEASIBILITY THE PRIMARY OBJECTIVE OF THIS CARBONSAFE PHASE II PROJECT IS TO ESTABLISH THE TECHNICAL AND COMMERCIAL FEASIBILITY OF A COMMERCIAL-SCALE CO2 GEOLOGICAL STORAGE COMPLEX FOR DESERET POWER ELECTRIC COOPERATIVE BONANZA POWER PLANT AND OTHER CO2 SOURCES IN THE NORTHEAST UINTA BASIN, UTAH.

DE-FE0031775 - UNIVERSITY OF UTAH - ''IMPROVING PRODUCTION IN THE EMERGING PARADOX OIL PLAY''

PAR-04-122 EXTRAMURAL FACILITIES CONSTRUCTION GRANT. "F*

WILLIAMS SYNDROME: BRIDGING COGNITION, BRAIN AND GENES

UTAH CENTER OF EXCELLENCE IN ELSI RESEARCH: UCEER

THE PURPOSE OF THIS AWARD IS TO PROVIDE FUNDING TO IMPLEMENT THE PROJECT ENTITLED IRAQI CONSTITUTIONAL AND LEGISLATIVE DEVELOPMENT (ICLD).

CENTER FOR IRON AND HEME DISORDERS (CIHD)

TRAINING IN CARDIOVASCULAR RESEARCH

THAPCA TRIALS - DCC APPLICATION

UNIVERSITY OF UTAH MANUFACTURING EXTENSION PARTNERSHIP CENTER (UUMEP)

NEUROPLASTICITY-BASED COMPUTERIZED COGNITIVE REMEDIATION (NCCR) FOR TREATMENT RESISTANT LATE-LIFE DEPRESSION - ABSTRACT THIS PROPOSAL IS SUBMITTED IN RESPONSE TO RFA-MH-18-707 AND NOT-MH-20-027, AND AIMS TO CONDUCT A RANDOMIZED, DOUBLE-BLIND, CONTROLLED CONFIRMATORY EFFICACY TRIAL OF A NOVEL, NEUROPLASTICITY-BASED COMPUTERIZED COGNITIVE REMEDIATION (NCCR) INTERVENTION FOR TREATMENT RESISTANT LATE-LIFE MAJOR DEPRESSIVE DISORDER (LLD). WE DEVELOPED NCCR TO TARGET COGNITIVE CONTROL DEFICITS (CCD), A BEHAVIORAL EXPRESSION OF ALTERED FUNCTION OF THE RESEARCH DOMAIN CRITERIA (RDOC)-DEFINED, COGNITIVE CONTROL NETWORK (CCN). THIS NOVEL INTERVENTION IS CONSISTENT WITH NIMH PRIORITIES TO ADVANCE INTERVENTIONS INFORMED BY COGNITIVE AND AFFECTIVE NEUROSCIENCE (STRATEGY 3.1) THAT CAN BE DISSEMINATED TO THE COMMUNITY (STRATEGY 3.3). IN LLD, DEFICITS IN COGNITIVE CONTROL FUNCTIONS (CCD) ARE COMMON, AND DISABLING. WE AND OTHERS HAVE DOCUMENTED THAT SPECIFIC CCD, AND THEIR UNDERLYING BRAIN NETWORK ABNORMALITIES, ARE ASSOCIATED WITH POOR RESPONSE TO ANTIDEPRESSANTS, RELAPSE, AND INCREASED RISK FOR SUICIDE. THESE DEFICITS ARE MEDIATED BY THE CCN, A FRONTOPARIETAL CIRCUIT THAT COMPRISES THE DORSOLATERAL PREFRONTAL CORTEX, DORSAL ANTERIOR CINGULATE CORTEX, AND POSTERIOR PARIETAL CORTEX, AS WELL AS PROJECTIONS TO THE VENTROMEDIAL PREFRONTAL CORTEX AND SUBCORTICAL STRUCTURES, INCLUDING THE STRIATUM. THE THEORY GUIDING NEUROPLASTICITY-BASED COGNITIVE INTERVENTIONS IS THAT NETWORK ABNORMALITIES ASSOCIATED WITH NEGATIVE DISEASE-SPECIFIC CLINICAL OUTCOMES CAN BE ALTERED THROUGH THE INDUCTION OF NEUROPLASTICITY (EVEN IN THE AGING BRAIN), RESULTING IN ENHANCED FUNCTIONING OF THE TARGET NETWORK, AND SYMPTOMATIC IMPROVEMENTS. THE METHODOLOGY WE EMPLOYED IS FOUNDED IN BASIC ANIMAL SCIENCE OF INDUCTION OF PLASTICITY IN THE AGING BRAIN, AND IT IS TRANSLATED INTO COMPUTER ALGORITHMS THAT DELIVER (1) INCREASINGLY CHALLENGING; (2) DYNAMIC DIFFICULTY ADJUSTED; (3) ATTENTION DEMANDING; AND (4) IMMEDIATELY REWARDING COGNITIVE TRAINING DESIGNED TO ACTIVATE CCD ASSOCIATED WITH POOR CLINICAL OUTCOMES. WE RECENTLY TESTED NCCR IN THREE PRELIMINARY CLINICAL TRIALS. OUR PRELIMINARY DATA INDICATE THAT NCCR WILL LIKELY ENGAGE OUR PROPOSED TARGET, CCD. FURTHER, NCCR APPEARS TO HAVE MORE ROBUST MOOD EFFECTS IN PARTICIPANTS WHO HAVE PRONOUNCED CCD, WHILE SSRI/SNRI- TREATED PATIENTS ARE TWO TIMES LESS LIKELY TO BENEFIT. WE DESIGNED NCCR TO BE: SHORT (4-WEEK DOSE), EFFICACIOUS, MOBILE (AVAILABLE VIA WEB), COST-EFFECTIVE (DOES NOT REQUIRE AN MD/PHD), WITH THE POTENTIAL FOR WIDE DISTRIBUTION, EASY ADOPTABILITY, AND EXTENSIBILITY TO ADDRESS THIS URGENT, UNMET THERAPEUTIC NEED IN LLD. FOR THESE PATIENTS THERE IS CURRENTLY NO TREATMENT THAT ADEQUATELY ADDRESSES BOTH MOOD AND COGNITIVE IMPAIRMENT. THE DATA PRODUCED BY THIS PROPOSAL WILL ALLOW US TO STUDY THE RELATIONSHIP BETWEEN CCD AND CHANGES IN MOOD, AND COMPARE THESE EFFECTS TO A CONTROL CONDITION IN LLD PARTICIPANTS WHO HAVE FAILED FIRST-LINE TREATMENTS. FURTHER, WE PROPOSE A TWO-SITE, SUFFICIENTLY POWERED TRIAL TO STUDY OUR TECHNOLOGY-FACILITATED PARAMETERS, AS WELL AS IMPLEMENTATION PROCEDURES IN TWO LARGE MEDICAL SYSTEMS, WHICH HAVE GREAT POTENTIAL TO INFORM FUTURE INTERVENTIONS OF THIS TYPE AND SUPPORT SCALABILITY OF MOBILE NCCR INTO “USUAL CARE” SETTINGS.

FEBIO - FINITE ELEMENTS FOR BIOMECHANICS AND BIOPHYSICS

CARDIOVASCULAR DEVELOPMENT DATA RESOURCE CENTER (CDDRC)

RACIAL/ETHNIC DISPARITIES IN OVARIAN CANCER TREATMENT AND SURVIVAL: AN INTEGRATIVE APPROACH

TAS::89 0321::TAS UNCONVENTIONAL AND RENEWABLE ENERGY RESEARCH UTILIZING ADVANCED COMPUTER SIMULATIONS - NEW AWARD

ENHANCING END-OF-LIFE AND BEREAVEMENT OUTCOMES AMONG CANCER CAREGIVERS

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

EMSC DATA CENTER

DESCRIPTION:THIS AGREEMENT PROVIDES FUNDING TO UNIVERSITY OF UTAH TO EXECUTE CAPACITY BUILDING, TRIBAL CAPACITY BUILDING, TRAINING, EDUCATION, AND RESEARCH AND DEMONSTRATION ACTIVITIES DESIGNED TO ADDRESS INDOOR AIR QUALITY (IAQ) ISSUES AND HELP REDUCE GREEN HOUSE GAS EMISSIONS (GHG) AT K-12 SCHOOLS IN LOW-INCOME, DISADVANTAGED, AND TRIBAL COMMUNITIES. SPECIFICALLY, THE RECIPIENT WILL HELP DEVELOP IAQ MANAGEMENT AND GHG REDUCTION PLANS FOR K-12 SCHOOLS IN UNDERSERVED URBAN AND RURAL AREAS IN UTAH, WYOMING (WITH THE NORTHERN ARAPAHO TRIBE IN , AND POTENTIALLY NEVADA (WITH THE SHO-PAI TRIBE). THIS WILL BE ACCOMPLISHED THROUGH ENERGY EFFICIENCY ASSESSMENTS OF SCHOOL-BUILDINGS, INDOOR/OUTDOOR AIR POLLUTANT MONITORING, RESEARCH AND DEMONSTRATION ACTIVITIES DESIGNED TO ILLUSTRATE THE EFFECTIVENESS OF VARIOUS IAQ AND GHG REDUCTION STRATEGIES, COMMUNITY ENGAGEMENT, TRAINING, AND EDUCATIONAL ACTIVITIES. IN ADDITION, A NATIONAL WEBINAR, WORKSHOPS, PHONE APP(S), FACTSHEETS, COMMUNITY IAQ ADVISORY BOARD(S) FOR THE PROJECT, AND GUIDANCE ON IMPROVING IAQ AND ENERGY EFFICIENCY IN SCHOOLS WILL ALSO BE DEVELOPED.ACTIVITIES:THE ACTIVITIES INCLUDE SCHOOL BUILDINGS ENERGY ASSESSMENTS, INDOOR/OUTDOOR AIR POLLUTION MONITORING AND AIR QUALITY, DEVELOPMENT OF IAQ MANAGEMENT AND GHG REDUCTION PLAN, AND RESEARCH AND DEMONSTRATION OF DIFFERENT INTERVENTIONS AND THEIR EFFECTIVENESS, AND TRAINING AND EDUCATION. THESE ACTIVITIES ARE ASSOCIATED WITH THE FOLLOWING PROJECT AREAS: 1. IAQ AND GHG REDUCTION CAPACITY BUILDING TARGETING FACILITY MANAGEMENT STAFF, HEALTH OFFICERS, AND KEY DECISION MAKERS AT K-12 SCHOOLS AND/OR SCHOOL DISTRICTS IN LOW-INCOME AND DISADVANTAGED COMMUNITIES. 2. TRIBAL IAQ AND GHG REDUCTION CAPACITY BUILDING TARGETING FACILITY MANAGEMENT STAFF, HEALTH OFFICERS, AND KEY DECISION MAKERS AT K-12 SCHOOLS IN TRIBAL COMMUNITIES. 3. IAQ AND GHG REDUCTION TRAINING AND EDUCATION CAMPAIGN FOR FACILITY MANAGEMENT STAFF AND HEALTH OFFICERS AT K-12 SCHOOLS AND SCHOOL DISTRICTS IN LOW-INCOME, DISADVANTAGED, AND TRIBAL COMMUNITIES, AND/OR THE DEVELOPMENT OF QUALIFIED K-12 SCHOOL STAFF NECESSARY TO EXECUTE COMPREHENSIVE IAQ AND GHG REDUCTION PLANS. 4. IAQ AND GHG REDUCTION RESEARCH AND DEMONSTRATION PROJECTS IN K-12 SCHOOLS LOCATED IN LOW-INCOME, DISADVANTAGED, AND/OR TRIBAL COMMUNITIES. SUBRECIPIENT:A SUBAWARD OF $43,364 FOR DHHS FOR DEVELOPING FACTSHEETS, DESIGNING/ADMINISTERING THE QUESTIONNAIRES, GUIDING THE SELECTION OF THRESHOLDS FOR THE TEXT S AND PARTICIPATING IN CAB MEETINGS. A $51,045 SUBAWARD FOR UCAIR IS INCLUDED FOR ORGANIZING THE WORKSHOPS AND LEADING THE CAB MEETINGS. A SUBAWARD OF $151,099 IS PROVIDED TO SNOW COLLEGE FOR COORDINATING WITH THE RURAL UTAH SCHOOLS AND DEPLOYING/MAINTAINING SENSORS AT THE SCHOOLS, CO-LOCATION WITH THEIR AIR QUALITY INSTRUMENTS AND PARTICIPATION IN OUTREACH ACTIVITIES.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE THE DEVELOPMENT OF FACTSHEETS, A NATIONAL WEBINAR, WORKSHOPS, COMMUNITY ADVISORY BOARD (CAB), TWO PHONE APPS, TEXT S AND GUIDANCE ON IMPROVING IAQ AND ENERGY EFFICIENCY IN SCHOOLS. THEY ALSO INCLUDE CONTAM MODEL PLATFORM, TECHNICAL REPORTS, PROJECT WEBSITE AND DATABASE. THESE ARE EXPECTED TO INCREASE IAQ AND GHG REDUCTION CAPACITY BUILDING ON A LOCAL, REGIONAL AND NATIONAL LEVEL, AND LEAD TO MORE PEER-REVIEWED SCIENTIFICALLY VALIDATED RESEARCH PUBLICATIONS ON IAQ AND ENERGY USE. ANTICIPATED DELIVERABLES: - 5 REGIONAL OR NATIONAL IAQ CONFERENCE(S) FOCUSED ON GHG REDUCTION AND IAQ INTERVENTION BEST PRACTICES, SCHOOL IAQ PLAN DEVELOPMENT, OR OTHER RELEVANT IAQ TOPICS FOR FACILITY MANAGEMENT STAFF, HEALTH OFFICERS, AND KEY DECISION MAKERS FROM K-12 SCHOOLS AND/OR SCHOOL DISTRICTS IN LOW-INCOME, DISADVANTAGED, AND/OR TRIBAL COMMUNITIES. - 7 IAQ AND GHG REDUCTION MANAGEMENT PLAN DEVELOPMENT COURSE(S) AND ASSOCIATED EDUCATIONAL MATERIALS DEVELOPED FOR FACILITY MANAGEMENT STAFF, HEALTH OFFICERS, AND KEY DECISION MAKERS FROM K-12 SCHOOLS AND/OR SCHOOL DISTRICTS IN LOW-INCO

UTAH CENTER FOR PROMOTION OF WORK EQUITY (U-POWER)

BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS

MOLECULAR GENETICS OF LYME ARTHRITIS SUSCEPTIBILITY

HEMATOLOGY CENTRAL COORDINATING CENTER (HCCC) FOR THE NIDDK HEMATOLOGY CENTERS PROGRAM

A COMPARATIVE EFFECTIVENESS STUDY OF SPEECH AND SURGICAL TREATMENTS USING A CLEFT PALATE REGISTRY/RESEARCH OUTCOMES NETWORK.

MULTI-CENTER IMPLEMENTATION AND VALIDATION OF EFFICIENT MAGNETIC RESONANCE IMAGING AND ANALYSIS OF ATHEROSCLEROTIC DISEASE OF THE CERVICAL CAROTID - ABSTRACT: NUMEROUS INVESTIGATIONS OVER THE PAST DECADES HAVE YIELDED SUBSTANTIAL INNOVATIONS IN MR METHODS FOR THE CHARACTERIZATION OF EXTRACRANIAL CAROTID ATHEROSCLEROSIS. IMAGES OBTAINED WITH THESE INNOVATIONS UNDER IDEAL CONDITIONS HAVE GIVEN CLINICIANS RICH INFORMATION ABOUT DISEASE IN THE ARTERIAL WALL AND THE HOPE FOR TOOLS CRITICALLY NEEDED FOR ADEQUATE MANAGEMENT OF THIS INSIDIOUS DISEASE. DESPITE THIS, THE GREAT POTENTIAL POWER OF THIS TECHNOLOGY HAS NOT MADE IT INTO THE ROUTINE CLINICAL ARMAMENTARIUM. INDEED, BECAUSE OF THE NEED FOR GADOLINIUM-BASED CONTRAST AGENTS (GBCA), THE LONG EXAM TIME (TYPICALLY ABOUT 45 MINUTES TO OBTAIN THE MULTIPLE CONTRASTS IN THE 5 OR 6 NECESSARY SEQUENCES), AND THE STEEP LEARNING CURVE REQUIRED TO INTERPRET MULTI- CONTRAST MRI MOST PRACTITIONERS STILL REVERT TO THE SIMPLIFIED METRIC OF DIAMETER STENOSIS IN ASSESSING RISK. AFTER MANY COLLECTIVE YEARS OF INVESTIGATIONS, THE CONSORTIUM OF INVESTIGATORS COLLABORATING ON THIS PROPOSAL BELIEVES THAT THE TIME IS RIGHT TO ADDRESS THESE REMAINING LIMITATIONS AND ULTIMATELY SHIFT THE CLINICAL PARADIGM. OVERARCHING HYPOTHESIS: TO ACHIEVE THE GREAT POTENTIAL IN THE MANAGEMENT OF CERVICAL CAROTID DISEASE, A HIGHLY EFFICIENT AND EASILY USED MRI TECHNIQUE IS REQUIRED. OUR HYPOTHESIS IS THAT THIS CAN BE ACCOMPLISHED USING MULTI-PARAMETRIC NON-CONTRAST MRI SEQUENCES COUPLED WITH THE LATEST HIGH SIGNAL TO NOISE RATIO (SNR) NECK-SHAPE-SPECIFIC (NSS) RF COILS AND INNOVATIVE MACHINE LEARNING (DEEP NEURAL NETWORK) ANALYSIS METHODS. AIM 1: WE WILL INSTALL IDENTICAL RF COILS, MRI SEQUENCES, AND PROTOCOLS AT EACH OF OUR 5 PARTICIPATING CENTERS AS WELL AS RIGOROUSLY TEST THE ACCURACY OF MEASUREMENTS AND REPRODUCIBILITY OF IMAGE QUALITY FROM ALL CENTERS. AIM 2: WE WILL DEVELOP, TRAIN, AND VALIDATE A USER FRIENDLY, DEEP LEARNING NEURAL NETWORK SYSTEM FOR THE QUANTITATIVE ANALYSIS OF SEVERAL KEY COMPONENTS CONSIDERED TO BE PRESENT IN THE VULNERABLE ATHEROSCLEROTIC PLAQUE. AIM 3: WE WILL APPLY THE ANALYSIS TO A COHORT OF CAROTID DISEASE SUBJECTS TO ESTABLISH THE REPEATABILITY OF THE QUANTITATIVE MEASURES, AS WELL AS THE ACCURACY OF CHARACTERIZATION IN COMPARISON TO HISTOPATHOLOGY. ALTHOUGH WE WILL DEVELOP AND TEST THE IMAGE QUALITY, REPRODUCIBILITY AND RELIABILITY IN A NETWORK OF HIGHLY SKILLED ACADEMIC CENTERS, WE WILL DESIGN THESE METHODS TO BE APPLICABLE IN THE COMMUNITY HOSPITAL SETTING. AT THE CONCLUSION OF THIS PROJECT, WE PROPOSE TO HAVE AN INTEGRATED SOLUTION THAT CAN BE USED IN SUBSEQUENT INVESTIGATIONS SUCH AS: THE EFFECT OF PHARMACOLOGIC INTERVENTION IN MODIFYING THE COMPOSITION OF THE PLAQUE; STUDYING THE EVOLUTION OF FEATURES OF THE UNTREATED ATHEROMATOUS DISEASE OVER TIME; AND, EVENTUALLY, INVESTIGATING THE METRICS THAT ARE PREDICTIVE OF DELETERIOUS OUTCOMES, AND THAT CAN BE USED IN IMPROVING INTERVENTION STRATEGIES IN THIS POPULATION. ON SUCCESSFUL COMPLETION, THE RF COILS AND MRI SEQUENCES AND ANALYSIS METHODS WILL BE MADE AVAILABLE TO OTHER IMAGING CENTERS IN A MANNER THAT ULTIMATELY CHANGES THE PARADIGM OF DIAGNOSIS AND MANAGING THE TREATMENT OF CERVICAL CAROTID ATHEROSCLEROTIC DISEASE.

ELEVATE CENTER: REDUCTION OF MATERNAL MORBIDITY FROM SUBSTANCE USE DISORDER IN UTAH - PROJECT SUMMARY ELEVATE CENTER ACCIDENTAL DRUG OVERDOSE AND SUICIDE WERE THE LEADING CAUSES OF PREGNANCY-ASSOCIATED DEATH IN UTAH FROM 2015-2020, ACCOUNTING FOR NEARLY 40% OF ALL PREGNANCY-ASSOCIATED DEATHS OVER THAT TIME PERIOD. AT-RISK POPULATIONS, INCLUDING THOSE IN RURAL SETTINGS AND THOSE WHO IDENTIFY AS AMERICAN INDIAN OR ALASKA NATIVE ARE DISPROPORTIONATELY AFFECTED BY MATERNAL MORBIDITY. WE BRING TOGETHER A TRANSDISCIPLINARY TEAM WITH EXPERTISE IN OBSTETRICS, ADDICTION MEDICINE, SIMULATION TRAINING, EXPERIENTIAL LEARNING, BIAS AND DISPARITY REDUCTION, COMMUNITY ENGAGEMENT AND IMPLEMENTATION SCIENCE. TOGETHER, THIS COLLABORATIVE TEAM WILL ESTABLISH THE ELEVATE MATERNAL HEALTH CENTER OF EXCELLENCE. ELEVATE IS NAMED TO ENCOMPASS OUR MISSION TO EXPAND OUR REACH ACROSS UTAH AND THE MOUNTAIN WEST, LEVERAGE EXISTING INFRASTRUCTURE, AND TREAT PREGNANT AND POSTPARTUM PEOPLE WITH SUBSTANCE USE DISORDER (SUD) WHO EXPERIENCE DISPARITIES TO ACHIEVE EQUITY. IN RESPONSE TO OUR COMMUNITY PARTNERS AND NEEDS OF DISPROPORTIONATELY AFFECTED POPULATIONS, WE PROPOSE THREE PROJECTS IN YEARS 1-5, WHICH WILL BE SCALED UP AND IMPLEMENTED STATEWIDE AND DISSEMINATED NATIONALLY IN YEARS 6 AND 7. PROJECT 1 (CEREMONY) WILL IMPLEMENT A CULTURALLY APPROPRIATE AND MULTIDISCIPLINARY PERINATAL CARE CLINIC FOR INDIVIDUALS WITH SUD AT SACRED CIRCLE CLINIC, WHICH IS A CLINIC SERVING NATIVE MOTHERS. PROJECT 2 (INSPIRE) WILL DEVELOP, IMPLEMENT AND TEST A MODULAR LEARNING INTERVENTION, ANCHORED IN SIMULATION TRAINING, FOR INTERPROFESSIONAL MEMBERS OF THE HEALTHCARE TEAM TO REDUCE BIAS RELATED TO SUD IN PREGNANCY. A ROBUST TRAIN- THE-TRAINER CURRICULUM WILL ALLOW US TO IMPLEMENT THE PROGRAM ACROSS THE STATE AND REACH RURAL COMMUNITIES. PROJECT 3 (MEMORIES) WILL REFINE AND TEST AN EXPANDED INFORMANT INTERVIEW TOOL TO ASCERTAIN COMMUNITY AND SYSTEMS CONTRIBUTIONS TO MATERNAL DEATHS, AND THE ROLE OF DISCRIMINATION IN DEATHS FROM SUD. THE TOOL WILL THEN BE DISSEMINATED NATIONALLY TO MATERNAL MORTALITY REVIEW COMMITTEES. OUR ELEVATE CENTER AIMS ARE TO: (1) PROVIDE INTEGRATED AND EFFICIENT LEADERSHIP OF THE THREE PROPOSED PROJECTS, MAXIMIZING COORDINATION WITH COMMUNITY PARTNERS AND INCORPORATING RESEARCH TRAINING ACROSS ALL ELEMENTS OF THE ELEVATE CENTER; (2) MATURE OUR EXISTING COMMUNITY PARTNERSHIPS AND STATEWIDE NETWORKS IN ORDER TO FACILITATE FUTURE IMPLEMENTATION SCIENCE AND EFFECTIVENESS TRIALS TO REDUCE MATERNAL MORBIDITY AND MORTALITY IN UTAH, AND (3) REDUCE MATERNAL MORBIDITY IN UTAH AND NATIONALLY THROUGH IMPLEMENTATION OF COMMUNITY-DRIVEN INTERVENTIONS AND TRAINING OF HEALTH CARE PRACTITIONERS. THE ELEVATE CENTER WILL RIGOROUSLY INVESTIGATE AND IDENTIFY CONTRIBUTORS TO MATERNAL MORBIDITY AND MORTALITY FROM SUD WITH A FOCUS ON RURAL AND NATIVE POPULATIONS. THE MULTIPRONGED APPROACH OF THE ELEVATE CENTER WILL REDUCE MATERNAL MORBIDITY FROM SUBSTANCE USE IN UTAH WHILE TRAINING THE NEXT GENERATION OF SCIENTISTS FOCUSED ON MORBIDITY REDUCTION. OUR EFFORTS CAN ULTIMATELY BE EXPANDED NATIONALLY TO ADDRESS A LEADING CAUSE OF PREGNANCY-ASSOCIATED DEATH IN THE U.S.

TOWARD FUNCTIONAL PRECISION ONCOLOGY TO PREDICT, PREVENT, AND TREAT EARLY METASTATIC RECURRENCE OF TRIPLE-NEGATIVE BREAST CANCER

NONPHARMACOLOGIC PAIN MANAGEMENT FOR LUMBAR SURGERY

BRIDGING PHYSICAL AND CULTURAL DETERMINANTS OF POSTPARTUM PELVIC FLOOR SUPPORT AND SYMPTOMS FOLLOWING VAGINAL DELIVERY

THE UTAH DIABETIC NEUROPATHY STUDY

COUPLING GENE EXPRESSION TO FLAGELLAR MORPHOGENESIS

DEVELOPMENTAL BIOLOGY TRAINING PROGRAM

UNLOCKING EVOLUTIONARILY LATENT IMMUNE FUNCTIONS FOR TREATING DISEASE

RETINAL REMODELING

CENTER FOR INTEGRATIVE BIOMEDICAL COMPUTING

EXAMINING EFFECTS OF INTENSIVE BP CONTROL ON MCI/DEMENTIA AND PLASMA BIOMARKER TRAJECTORIES BY AD PATHOLOGY: ELUCIDATING NEUROPROTECTIVE EFFECTS IN THE RACIALLY AND ETHNICALLY DIVERSE SPRINT TRIAL - ABSTRACT: ALZHEIMER’S DISEASE (AD) AND AD-RELATED DEMENTIAS (AD/ADRD) ARE LEADING CAUSES OF DEPENDENCE AND DISABILITY IN OLDER ADULTS, PROJECTED TO IMPACT ~153 MILLION PEOPLE WORLDWIDE BY 2050. HYPERTENSION (HTN) INCREASES THE RISK OF BOTH AD AND VASCULAR COGNITIVE IMPAIRMENT AND DEMENTIA (VCID). BLACK AND HISPANIC ADULTS HAVE HIGHER AVERAGE BLOOD PRESSURE (BP) AND NEARLY 1.5 TO 2 TIMES HIGHER DEMENTIA INCIDENCE THAN WHITE ADULTS, DESPITE HAVING LESS BRAIN Β-AMYLOID (AΒ). THE SYSTOLIC BLOOD PRESSURE INTERVENTION TRIAL (SPRINT), WHICH INCLUDED 9,361 US ADULTS, FOUND THAT INTENSIVE VS STANDARD SYSTOLIC BP (SBP) TREATMENT (<120 VS <140 MM HG) REDUCED RISK OF COMBINED EMERGENT MILD COGNITIVE IMPAIRMENT (MCI) OR DEMENTIA. EPIDEMIOLOGICAL EVIDENCE SUGGESTS A SYNERGISM BETWEEN SBP AND AD PATHOLOGY; HOWEVER, SIGNIFICANT GAPS REMAIN IN OUR UNDERSTANDING THE ROLE AD PATHOLOGY PLAYS IN HOW INTENSIVE SBP CONTROL AFFECTS MCI/DEMENTIA RISK OVERALL AND IF THERE ARE DIFFERENCES BY SEX, RACE/ETHNICITY, AND APOE Ε4 GENOTYPE (Ε4). UNDERSTANDING THE EXTENT TO WHICH INTENSIVE SBP TREATMENT AFFECTS DEMENTIA RISK IN THE PRESENCE OR ABSENCE OF AD PATHOLOGY AND BY AGE, RACE/ETHNICITY, AND SEX CAN REFINE HTN TREATMENT STRATEGIES TO LOWER DEMENTIA RISK AND INFORM FUTURE TRIAL DESIGNS. WE WILL ASSESS AD/ADRD PLASMA BIOMARKERS LONGITUDINALLY USING STORED SPRINT PLASMA SAMPLES (4 TIME POINTS; N=8,797; MEAN AGE AT BASELINE 68 YEARS; 40% BLACK OR HISPANIC; MEDIAN 7 YEARS FOLLOW-UP). WE WILL DETERMINE WHETHER BASELINE AD PATHOLOGY OR Ε4 MODIFIES THE EFFECTS OF INTENSIVE SBP CONTROL ON MCI/DEMENTIA; WHETHER INTENSIVE SBP CONTROL REDUCES LONGITUDINAL CHANGE IN AD BIOMARKERS (PTAU217, AΒ 42/40), NEURODEGENERATION (NEUROFILAMENT LIGHT; NFL), MEASURES OF VASCULAR REMODELING (PLACENTAL GROWTH FACTOR; PLGF), OR NEUROINFLAMMATION (GLIAL FIBRILLARY ACIDIC PROTEIN; GFAP); HOW THIS VARIES BY BASELINE AD PATHOLOGY, Ε4, RACE/ETHNICITY, AGE, AND SEX; AND WHICH PLASMA BIOMARKER(S), INCLUDING NOVEL BIOMARKER CANDIDATES ASSESSED ON THE NULISA PLATFORM, CAN PREDICT DEMENTIA RISK. THE AIMS ARE: (1) DETERMINE EFFECTS OF INTENSIVE VS STANDARD SBP CONTROL ON MCI/DEMENTIA (PRIMARY) BY BASELINE AD PATHOLOGY (PRIMARY EFFECT MODIFIER) AND BY AGE, SEX, RACE/ETHNICITY, AND Ε4 (SECONDARY EFFECT MODIFIERS); (2) DETERMINE EFFECTS OF INTENSIVE VS STANDARD SBP CONTROL ON LONGITUDINAL AD/ADRD BIOMARKERS, OVERALL AND IN SUBGROUPS; AND (3) PROVIDE A SHARED PUBLIC REPOSITORY OF AD/ADRD BIOMARKER DATA TO INVESTIGATE THE EFFECT OF OTHER BIOLOGICAL AND NON-BIOLOGICAL RISK MODIFIERS IN THE DIVERSE AND WELL-CHARACTERIZED SPRINT TRIAL. EXPLORATORY WORK WILL USE PROTEOMICS TO IDENTIFY ADDITIONAL PLASMA BIOMARKERS THAT ADD TO ESTABLISHED AD/ADRD BIOMARKERS IN EXPLAINING THE EMERGENCE OF DEMENTIA. THIS PROJECT WILL HELP INFORM PATIENT SELECTION FOR PARTICULAR THERAPIES, CREATE A SHAREABLE RESEARCH RESOURCE, AND EXAMINE HOW CROSS-SECTIONAL AND LONGITUDINAL PLASMA BIOMARKERS CAN BE APPLIED IN A LARGE, REPRESENTATIVE POPULATION OF AT-RISK OLDER ADULTS.

CONSERVATION AND SUSTAINABLE USE OF BIODIVERSITY IN PNG

MIRNA AND COLORECTAL CANCER: ASSOCIATIONS WITH TUMOR PHENOTYPE AND SURVIVAL

TRAINING LONG TERM - LEND NEURODEVELOPMENTAL DISABILITIES

MULTI-SECTOR, MULTI-LEVEL INTERVENTIONS FOR IMPROVING CANCER PREVENTION AND CONTROL ADDRESSING PERSISTENT POVERTY - OVERALL: PROJECT SUMMARY THE OVERALL, LONG-TERM GOAL OF “HOPE & CAIRHE 2GETHER (HC2)” IS TO INCREASE THE REACH OF EVIDENCE-BASED CANCER PREVENTION AND CONTROL INTERVENTIONS (EBIS) IN AREAS OF PERSISTENT POVERTY (PP). HC2 BRINGS TOGETHER THE EXPERTISE, INFRASTRUCTURE, PARTNERSHIPS, AND RESOURCES OF THE CENTER FOR HEALTH OUTCOMES AND POPULATION EQUITY (HOPE), HUNTSMAN CANCER INSTITUTE, AND UNIVERSITY OF UTAH, WITH THE CENTER FOR AMERICAN INDIAN AND RURAL HEALTH EQUITY (CAIRHE) AND MONTANA STATE UNIVERSITY. HC2’S COMMUNITY LEVEL, TRANSLATIONAL RESEARCH PROGRAMS ALIGN WITH COMMUNITIES’ CULTURAL BELIEFS, RESOURCES, AND PRIORITIES; REACH ACROSS THE LIFESPAN; AND, STRATEGICALLY PARTNER WITH KEY “ANCHOR ORGANIZATIONS,” PUBLIC HEALTH AGENCIES, HEALTHCARE SYSTEMS, AMERICAN INDIAN COMMUNITIES, AND COMMUNITY ORGANIZATIONS ACROSS FIVE STATES. THE HC2 NETWORK BRINGS TOGETHER THE ROBUST COMMUNITY PARTNERSHIPS ACROSS INSTITUTIONS TO CREATE A UNIQUE RESOURCE FOR ADVANCING CANCER PREVENTION IN PP AREAS IN THE MOUNTAIN WEST, AND HC2 IS GUIDED BY A COMMUNITY AND SCIENTIFIC ADVISORY BOARD. PROJECTS 1 AND 2 ADDRESS THE MAJOR DRIVERS OF THE DISPROPORTIONATE BURDEN OF CANCER AMONG PP AREAS AND POPULATIONS. PROJECT 1 PARTNERS WITH COMMUNITY HEALTH CENTERS (CHCS) TO ADDRESS TOBACCO CESSATION AND MITIGATE THE NEGATIVE IMPACTS OF THE SOCIAL DETERMINANTS OF HEALTH (SDOH) AMONG CHC PATIENTS IN UTAH WHO USE TOBACCO AND LIVE IN PP CENSUS TRACTS (MAJORITY LATINO). PROJECT 2 PARTNERS WITH COOPERATIVE EXTENSION SYSTEMS (CES) TO ADDRESS OBESITY PREVENTION AND SDOH AMONG AMERICAN INDIAN COMMUNITIES LOCATED IN PP CENSUS TRACTS IN MONTANA, OREGON, SOUTH DAKOTA, AND WISCONSIN (ALL CENSUS TRACTS ARE RURAL/FRONTIER). BOTH PROJECTS INCLUDE PROJECT STEERING COMMITTEES AND PROJECT 2 INCLUDES LOCAL COMMUNITY ADVISORY BOARDS IN EACH COMMUNITY. AN OVERARCHING THEME CREATING SYNERGY ACROSS HC2 ACTIVITIES AND RESEARCH IS INCREASING “REACH THROUGH EQUITABLE IMPLEMENTATION.” AS SUCH, HC2 IMPLEMENTATION STRATEGIES ARE SPECIFICALLY TAILORED TO LOCAL AND COMMUNITY CONTEXTS. HC2’S STRUCTURE AND FUNCTION CREATES SUBSTANTIAL SYNERGY TO ADVANCE CANCER PREVENTION RESEARCH IN AREAS AND POPULATIONS EXPERIENCING PERSISTENT POVERTY VIA: COMPLEMENTARY AREAS OF EXPERTISE, EXPERIENCE, COMMUNITY ENGAGEMENT, AND LEADERSHIP ACROSS INSTITUTIONS; INNOVATIVE, COMPREHENSIVE, MULTI- LEVEL, CONCEPTUAL FRAMEWORK TARGETING REACH THROUGH EQUITABLE IMPLEMENTATION, WITH SHARED RESEARCH FOCI THAT DRIVE THE RESEARCH PROGRAMS; MULTI-FACETED, CROSS-INSTITUTIONAL TRAINING PROGRAM THAT LEVERAGES THE COMPLEMENTARY STRENGTHS AND ACCESS TO TRAINEE POPULATIONS ACROSS UTAH AND MONTANA; AND, COMBINING DEEP AND EXTENSIVE COMMUNITY ENGAGEMENT AND ROBUST PARTNERSHIPS ACROSS INSTITUTIONS TO CREATE THE HC2 NETWORK, WHICH WILL HELP BRIDGE THE GAP BETWEEN SCIENTIFIC DISCOVERY AND THE IMPLEMENTATION OF EBIS IN AREAS OF PP. IN SUM, HC2 WILL BUILD ON EXISTING EXPERTISE, RESEARCH INFRASTRUCTURES, AND LONGSTANDING PARTNERSHIPS TO SERVE AS A REGIONAL AND NATIONAL LEADER IN COMMUNITY-ENGAGED CANCER PREVENTION AND CONTROL RESEARCH IN AREAS OF PP.

IMPROVING VARENICLINE ADHERENCE AND OUTCOME IN HOMELESS SMOKERS

OAC: PILOTING THE NATIONAL SCIENCE DATA FABRIC: A PLATFORM AGNOSTIC TESTBED FOR DEMOCRATIZING DATA DELIVERY

PRISMS INFORMATICS PLATFORM - FEDERATED INTEGRATION ARCHITECTURE

BIOMECHANICS OF THE SEMICIRCULAR CANALS

BIOCHEMISTRY OF HIV-1 BUDDING

THE NATURE AND FUNCTION OF GENOMIC IMPRINTING IN MONOAMINERGIC NEURONS

BORRELIA BURGDORFERI MITOGEN IN DEVELOPMENT OF ARTHRITIS

LEVERAGING AN ELECTRONIC MEDICAL RECORD INFRASTRUCTURE TO IDENTIFY PRIMARY CARE PATIENTS ELIGIBLE FOR GENETIC TESTING FOR HEREDITARY CANCER AND EVALUATE NOVEL CANCER GENETICS SERVICE DELIVERY MODELS

SUSTAINED-RELEASE DRUG DELIVERY DEVICE TO MANAGE BIOFILM IMPLANT-RELATED INFECTION

CONTROL OF ALCOHOL RESPONSES BY ACTIN-REGULATING GENES

NATIONAL EMERGENCY MEDICAL SERVICES FOR CHILDREN (EMSC) DATA ANALYSIS RESOURCE CENTER DEMONSTRATION

STRUCTURE AND FUNCTION OF CELL ADHESION SITES

TRP CHANNELS AND AIR POLLUTION

VIRUS-LIKE INTERCELLULAR COMMUNICATION IN THE NERVOUS SYSTEM

STUDYING THE INITIATION, PROGRESSION AND THERAPY OF LUNG CANCER IN MOUSE MODELS

POPULATION GENETICS OF MOBILE ELEMENTS

DECIPHERING GENE-ENVIRONMENT INTERACTIONS IN PATHOLOGICAL REACTIVE AGGRESSION

DIVERSE DRUG LEAD COMPOUNDS FROM BACTERIAL SYMBIONTS IN PHILIPPINE MOLLUSKS

RECURRENT LARYNGEAL NERVE CONNECTIVE TISSUES AS A FACTOR IN VOCAL FOLD PARALYSIS

NONPHARMACOLOGIC PAIN MANAGEMENT IN FQHC PRIMARY CARE CLINICS - PROJECT SUMMARY CHRONIC PAIN IS A UBIQUITOUS PROBLEM AND GROWING CONCERN FOR SOCIETY, CONTRIBUTING SUBSTANTIALLY TO THE ONGOING OPIOID EPIDEMIC. BACK PAIN IS THE MOST COMMON CHRONIC PAIN DIAGNOSIS AND THE MOST COMMON DIAGNOSIS FOR WHICH OPIOIDS ARE PRESCRIBED. CLINICAL PRACTICE GUIDELINES AND OPIOID-PRESCRIBING RECOMMENDATIONS MAKE IT CLEAR THAT NONPHARMACOLOGIC PAIN TREATMENTS ARE PREFERABLE TO OPIOIDS FOR PATIENTS WITH BACK PAIN. DESPITE UNEQUIVOCAL EVIDENCE, OVER-PRESCRIBING OF OPIOIDS TO INDIVIDUALS WITH BACK PAIN PERSISTS. PRIMARY CARE PROVIDERS SERVING RURAL AND LOW INCOME COMMUNITIES FACE SPECIFIC CHALLENGES TO PROVIDING NONPHARMACOLOGIC PAIN CARE INSTEAD OF OVER-RELIANCE ON OPIOIDS. PROVIDERS OF NONPHARMACOLOGIC CARE ARE OFTEN ABSENT FROM THESE COMMUNITIES AND EVEN IF PRESENT MAY BE INACCESSIBLE TO PATIENTS WITH LIMITED FINANCIAL RESOURCES. MANY RURAL AND LOW INCOME COMMUNITIES ARE SERVED BY FEDERALLY-QUALIFIED HEALTH CENTERS (FQHCS). FQHCS OFTEN SERVE COMMUNITIES AT THE FOREFRONT OF THE OPIOID CRISIS BUT TOO OFTEN LACK OPTIONS TO PROVIDE ACCESSIBLE NONPHARMACOLOGIC ALTERNATIVES TO THE PATIENTS THEY SERVE. THIS PROJECT DESCRIBES A 1-YEAR PLANNING PHASE FOLLOWED BY A 4-YEAR CLINICAL TRIAL THAT WILL COMPARE THE EFFECTIVENESS OF DIFFERENT STRATEGIES TO PROVIDE EFFICACIOUS NONPHARMACOLOGIC INTERVENTIONS TO PATIENTS WITH BACK PAIN SEEKING CARE IN FQHCS THROUGHOUT THE STATE OF UTAH. THE STRATEGIES EVALUATED ARE DESIGNED TO OVERCOME THE BARRIERS SPECIFIC TO RURAL AND LOW INCOME COMMUNITIES SERVED BY FQHC CLINICS THROUGH INNOVATIVE USE OF TELEHEALTH RESOURCES. THE RANDOMIZED CLINICAL TRIAL WILL EVALUATE TWO INTERVENTIONS STRATEGIES, ONE PROVIDING BOTH A BRIEF PAIN TELECONSULT WITH PHONE-BASED PHYSICAL THERAPY, THE OTHER USES AN ADAPTIVE STRATEGY – PROVIDING THE BRIEF PAIN TELECONSULT FIRST, FOLLOWED BY PHONE-BASED PHYSICAL THERAPY AMONG THOSE NON-RESPONSIVE TO THIS TREATMENT. WE WILL ALSO EVALUATE OUTCOMES RELATED TO THE EFFORTS TO IMPLEMENT STRATEGIES IN FQHC CLINICS IN ORDER TO PROVIDE VALUABLE INFORMATION FOR FUTURE EFFORTS TO SCALE EFFECTIVE STRATEGIES INTO OTHER LOW RESOURCE HEALTH CARE SETTINGS. OUR CLINICAL TRIAL HAS 4 SPECIFIC AIMS: 1) COMPARE THE EFFECTIVENESS OF A PAIN TELECONSULT INTERVENTION WITH OR WITHOUT PHONE-BASED PHYSICAL THERAPY FOR PATIENTS WITH CHRONIC BACK PAIN IN FQHCS, 2) COMPARE THE EFFECTIVENESS OF DIFFERENT 2-PHASE TREATMENT STRATEGIES IN WHICH PHONE-BASED PHYSICAL THERAPY IS CONSIDERED EITHER A FIRST-LINE OR SECOND-LINE OPTION, 3) EXAMINE THE RESULTS FOR AIMS 1 & 2 IN PRE-SPECIFIED SUB- GROUPS OF PATIENTS BASED ON BASELINE CHARACTERISTICS, AND 4) EXAMINE IMPLEMENTATION OUTCOMES OF THE PAIN TELECONSULT INCLUDING ACCEPTABILITY, ADOPTION, FEASIBILITY AND FIDELITY.

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

"DIFFERENTIAL EFFECTS OF METHAMPHETAMINE AND COCAINE"

UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE-UL1

HUMAN GENETIC VARIATION AND DISEASE

BIPARTISAN INFRASTRUCTURE LAW (BIL) - ADVANCED PROCESSING FOR CRITICAL MATERIALS EXTRACTION, RECOVERY, SEPARATION, AND PURIFICATION THE OBJECTIVES OF THIS PROJECT IS TO 1) EVALUATE TECHNOLOGIES FOR PHYSICAL UPGRADING OF SAMPLE FEEDSTOCK MATERIALS, 2) EXTRACT RARE EARTH ELEMENTS (REE)/CRITICAL MINERALS AND MATERIALS (CMM) USING ENVIRONMENTALLY FRIENDLY METHODS, 3) SEPARATE REE/CMM MATERIALS INTO INDIVIDUAL HIGH PURITY RARE EARTH SALTS (RES)/RARE EARTH OXIDES (REO)/CMM PRODUCTS, 4) PRODUCE HIGH PURITY REM/CMM USING INNOVATIVE REDUCTION TECHNOLOGIES, 5) EVALUATE THE OVERALL INTEGRATED PROCESS FOR ENERGY AND MASS BALANCES THROUGH TECHNOECONOMIC ANALYSIS, AND 6) PRODUCE AN ASSOCIATED ENERGY EQUITY FORECAST AND WORKFORCE IMPACT ASSESSMENT TO GAUGE POTENTIAL COMMUNITY BENEFITS IN THE EVENT OF ADOPTION OF THE INNOVATION TECHNOLOGIES BY INDUSTRY.

GLOBAL CENTERS TRACK 1: U.S.-CANADA CENTER ON CLIMATE-RESILIENT WESTERN INTERCONNECTED GRID -------------------------------------------------------------------------------------------------------------------- EXTREME CLIMATE EVENTS, SUCH AS HEAT WAVES OR WILDFIRES, OFTEN DISRUPT THE POWER GRID. THESE DISTURBANCES AFFECT THE LIVES OF MANY AND IMPEDE ENTERPRISE PRODUCTIVITY. IT IS THUS CRITICAL TO MODERNIZE THE GRID AND ENSURE THAT IT CAN WITHSTAND OR RECOVER QUICKLY FROM THE INTENSIFYING EFFECTS OF CLIMATE DISTURBANCES. ENGINEERING A CLIMATE-RESILIENT GRID IS, HOWEVER, CHALLENGING. IT REQUIRES BETTER UNDERSTANDING AND FORECASTING OF CLIMATE-DRIVEN DISTURBANCE RISKS. GRID STABILITY ALSO DEPENDS ON END-USER ENERGY DEMAND. FURTHERMORE, GRIDS IN THE WESTERN U.S. AND CANADA ARE INTERCONNECTED WHICH ADDS TO THE COMPLEXITY AND REQUIRES INTERNATIONAL COLLABORATION. THE U.S.-CANADA CENTER ON CLIMATE-RESILIENT WESTERN INTERCONNECTED GRID BRINGS TOGETHER AN INTERNATIONAL TEAM OF RESEARCHERS TO ASSESS THE RISK OF EXTREME EVENT FOR POWER GRIDS USING STATE-OF-THE-ART MODELING TOOLS. THE CENTER DEVELOPS NEW TECHNOLOGIES AND DESIGN ADAPTATION AND MITIGATION SOLUTIONS TO OVERCOME DISTURBANCES. THE CENTER LEVERAGES MULTI-FACETED PARTNERSHIPS ACROSS ACADEMIA, INDUSTRY, GOVERNMENT, AND COMMUNITIES AND EXPERTISE AND RESOURCES IN BOTH THE U.S. AND CANADA. IT ENGAGES STAKEHOLDERS BEYOND ACADEMIA TO ENSURE FORESEEABLE APPLICATIONS OF THE RESEARCH OUTCOMES. BY LEVERAGING CROSS-BORDER COLLABORATION, IT CREATES KNOWLEDGE AND TECHNOLOGIES THAT CAN BE APPLIED BEYOND THE CONTEXT OF THE WESTERN U.S. AND CANADA REGION, GLOBALLY. THIS AWARD ALSO PROVIDES SUPPORT FOR UNDERGRADUATE AND GRADUATE STUDENTS AT THE UNIVERSITIES OF UTAH AND NEW MEXICO AND OTHER PROFESSIONALS IN CALIFORNIA AND NEVADA, AS WELL AS OUTREACH AND EDUCATIONAL ACTIVITIES TO LOCAL COMMUNITIES IN THE WESTERN U.S. THE CENTER PURSUES FOUR MAJOR USE-INSPIRED RESEARCH PRIORITIES: (A) CREATE CUSTOMIZED MODELS FOR RISK QUANTIFICATION AND FORECASTING OF REGIONAL EXTREME DISTURBANCES TO BETTER PREPARE FOR POTENTIAL DISRUPTIONS TO POWER GRIDS; (B) ESTABLISH A COMPREHENSIVE UNDERSTANDING OF COMMUNITY NEEDS, CAPACITIES, AND ADAPTATION PROCESSES TOWARDS CLIMATE-DRIVEN EXTREME DISTURBANCES, IN ORDER TO DEVELOP EFFECTIVE CLIMATE-RESILIENCE STRATEGIES; (C) BUILD A FEDERATED CYBERINFRASTRUCTURE FOR COLLECTING, GOVERNING, AND SHARING CLIMATE AND GRID DATA, IN ORDER TO FACILITATE COLLABORATION AND INFORMATION EXCHANGE AMONG STAKEHOLDERS; (D) DEVELOP NEW MODELS FOR SHORT-TERM OPERATION AND LONG-TERM PLANNING OF POWER SYSTEMS THAT ARE INFORMED BY THE AFOREMENTIONED DATA AND INSIGHTS. THIS AWARD IS FUNDED BY THE GLOBAL CENTERS PROGRAM, AN INNOVATIVE PARTNERSHIP WITH FUNDING AGENCIES IN AUSTRALIA, CANADA AND THE UNITED KINGDOM, TO JOINTLY SUPPORT USE-INSPIRED RESEARCH ADDRESSING GLOBAL CHALLENGES IN CLIMATE CHANGE AND CLEAN ENERGY. PARTNERSHIPS WITH THE COMMONWEALTH SCIENCE AND INNOVATION RESEARCH ORGANISATION (CSIRO), NATURAL SCIENCE AND ENGINEERING RESEARCH COUNCIL OF CANADA (NSERC), SOCIAL SCIENCE AND HUMANITIES RESEARCH COUNCIL OF CANADA (SSHRC), AND UK RESEARCH AND INNOVATION (UKRI) LEVERAGE RESOURCES TO TACKLE CHALLENGES AT A LARGER SCALE THAN WOULD BE POSSIBLE FOR ONE FUNDING AGENCY ALONE. THIS CENTER IS JOINTLY SUPPORTED BY NSF AND NSERC. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

SMART EMBEDDED INTERVENTION FOR MILITARY POSTSURGICAL ENGAGEMENT READINESS (SEMPER)

TRAINING PROGRAM IN MICROBIAL PATHOGENESIS

RESEARCH TRAINING IN HEMATOLOGY

HIS-PURKINJE PACING FOR LOW ENERGY IMPLANTABLE CARDIOVERTER DEFIBRILLATORS

SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANS

REGIONAL AND URBAN SEISMIC MONITORING: WASATCH FRONT, UTAH, AND NEIGHBORING INTERMOUNTAIN WEST REGION

EVALUATING A NOVEL SLEEP-FOCUSED MIND-BODY REHABILITATIVE PROGRAM FOR VETERANS WITH MTBI AND OTHER "POLYTRAUMA" SYMPTOMS: AN RCT STUDY

BRIEF COGNITIVE BEHAVIORAL THERAPY (BCBT) REPLICATION TRIAL

INFLUENCE OF SUBGLOTTIC ANATOMY ON VOICE PRODUCTION

THE UTAH STUDY OF FERTILITY, LONGEVITY AND AGING

A NOVEL CHEMICAL PATHWAY FOR TITANIUM PRODUCTION - DRASTICALLY REDUCE COST

HUNTSMAN CANCER INSTITUTE/ UNIVERSITY OF UTAH NETWORK LEAD ACADEMIC PARTICIPATING SITE APPLICATION

INTERMOUNTAIN WEST CLINICAL CENTER FOR A CHILDHOOD LIVER DISEASE RESEARCH NETWORK

(MURI FY08) NANOCATALYSTS IN PROPULSION: MECHANISMS AND OPTIMIZATION (THE GRANTEE'S TECHNICAL PROPOSAL); THE RESEARCH TERMS AND CONDITIONS, 1 JULY 2

SYMPTOMCARE@HOME (SCH): DECONSTRUCTING AN EFFECTIVE, TECHNOLOGY-ASSISTED, SYMPTOM MANAGEMENT INTERVENTION

REGULATION AND FUNCTION OF DROSOPHILA NUCLEAR RECEPTORS

CALYPSO: A WEB SOFTWARE SYSTEM SUPPORTING TEAM-BASED, LONGITUDINAL GENOMIC DIAGNOSTIC CARE - PROJECT SUMMARY/ABSTRACT SOME OF THE MOST CHALLENGING DIAGNOSTIC CASES INVOLVE PATIENTS WHO PRESENT WITH COMPLEX PHENOTYPES THAT EVOLVE OVER TIME AND INTERSECT MULTIPLE MEDICAL DISCIPLINES. THE TWO PRIMARY CLINICAL SETTINGS FOR DIAGNOSING SUCH PATIENTS ARE UNDIAGNOSED DISEASE CLINICS AND NEONATAL INTENSIVE CARE UNIT RAPID GENOME SEQUENCING PROGRAMS. THESE CLINICS HAVE ADOPTED AN APPROACH WHERE DIAGNOSTIC ANALYSIS IS BASED ON COMPREHENSIVE GENOMIC SEQUENCING DATA; AND ANALYSIS IS CARRIED OUT BY A LARGE, COLLABORATIVE CLINICAL TEAM. THIS TEAM-BASED APPROACH LEVERAGES THE TREATING PHYSICIAN’S DETAILED UNDERSTANDING OF THE PATIENT’S PHENOTYPE, THE MEDICAL GENETICIST’S DEEP KNOWLEDGE OF GENETIC DISEASES, THE BIOINFORMATIC ANALYST’S EXPERTISE IN ADJUDICATING A VARIANT’S QUALITY AND PREDICTED PATHOGENICITY, AS WELL AS THE DIAGNOSTIC PATHOLOGIST’S ABILITY TO SYNTHESIZE ALL RELEVANT INFORMATION AND REACH A CONCLUSION REGARDING A GIVEN VARIANT’S CLINICAL SIGNIFICANCE. DIAGNOSTIC ANALYSIS OF PATIENTS IN BOTH OF THESE ENVIRONMENTS IS A LONG-TERM PROCESS THAT OFTEN CONTINUES FOR MONTHS OR EVEN YEARS, UNTIL NEW PHENOTYPES IN THE PATIENT ARE OBSERVED OR NOVEL GENE-DISEASE ASSOCIATIONS ARE REPORTED IN THE LITERATURE THAT PROVIDE THE NECESSARY INSIGHT FOR CASE SOLUTION. HOWEVER, EXISTING SOFTWARE TOOLS TYPICALLY ONLY CATER TO THE BIOINFORMATICIAN EXPERT OR THE DIAGNOSTIC MOLECULAR PATHOLOGIST, BUT NOT THE TREATING PHYSICIAN OR THE GENETIC COUNSELOR; FOCUS ON MAKING A GENETIC DIAGNOSIS AT A SINGLE TIMEPOINT, RATHER THAN FOLLOWING THE PATIENT OVER TIME DURING A LENGTHY DIAGNOSTIC PROCESS, AND ARE THEREFORE UNABLE TO ADEQUATELY SUPPORT TEAM-BASED, LONGITUDINAL GENOMIC DIAGNOSTIC CARE. ADDRESSING THIS PRESSING NEED, HERE WE PROPOSE TO DEVELOP A COMPREHENSIVE SOFTWARE SYSTEM, CALYPSO, TO ADDRESS THIS PRESSING NEED. CALYPSO WILL SUPPORT TEAM-BASED DIAGNOSTICS VIA INTUITIVE AND VISUAL IOBIO WEB TOOLS TAILORED FOR EACH TEAM MEMBER’S SPECIALIZED CONTRIBUTION TO DIAGNOSTIC ANALYSIS; AND FACILITATE LONG-TERM GENOMIC CARE BY KEEPING PATIENT GENOMIC DATA UP-TO-DATE VIA A SYSTEMATIC VARIANT RE- ANNOTATION INFRASTRUCTURE. WE WILL PUT CALYPSO INTO THE HANDS OF THE CLINICAL TEAMS IN OUR UNDIAGNOSED DISEASE CLINIC AND OUR NEONATAL INTENSIVE CARE UNIT, IDEAL TESTING GROUNDS FOR EVALUATING OUR TOOL’S IMPACT ON LONG-TERM GENOME DIAGNOSTIC CARE IN THE CONTEXT OF TEAM-BASED MEDICINE. WE WILL ALSO CENTRALLY DEPLOY AND EVALUATE OUR TOOL IN NHGRI’S UNDIAGNOSED DISEASE NETWORK TO HELP REALIZE THE COLLABORATIVE DIAGNOSTIC OPPORTUNITIES PRESENTED BY A LARGE, CLINICALLY FOCUSED RESEARCH CONSORTIUM.

BIOCHEMISTRY OF HIV-1 BUDDING

ANATOMICAL AND FUNCTIONAL ORGANIZATION OF INTER-AREAL FEEDBACK CIRCUITS IN THE VISUAL CORTEX, AND THEIR IMPACT ON NEURONAL RESPONSES

NICHD MATERNAL FETAL MEDICINE UNITS NETWORK

BIOCHEMICAL AND GENETIC ANALYSIS OF YFACT, A NOVEL NUCLEOSOME REORGANIZING FACTOR

REGULATION OF RETINAL NEUROGENESIS BY BHLH FACTORS

UNIVERSITY OF UTAH MANUFACTURING EXTENSION PARTNERSHIP (UUMEP) CENTER

THE EFFECT OF ELECTRONIC INFORMED CONSENT INFORMATION (EICI) ON RESIDUAL NEWBORN SPECIMEN RESEARCH

VARIATION IN PLATELET FUNCTION: THE GENETICS OF PLATELET GENE EXPRESSION

DISCOVERY AND MECHANISM OF BIOSYNTHETIC ENZYMES

COMMON AND RARE SEQUENCE VARIANTS IN BREAST CANCER RISK

INTERDISCIPLINARY TRAINING PROGRAM IN METABOLISM

RETINAL CIRCUITRY

ANALYSIS OF GLUTAMATE RECEPTOR FUNCTION IN C. ELEGANS

MAMMALIAN PHOTOTRANSDUCTION: ROLE OF CGMP AND CALCIUM

UTAH SPACE GRANT CONSORTIUM PROPOSAL FOR NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM OPPORTUNITIES IN NASA.STEM FY 2020-2024

A HIGH-THROUGHPUT MODEL FOR HUMAN MELANOMA

ADVANCED NURSING EDUCATION WORKFORCE

TOWARDS QUANTITIATIVE UNDERSTANDING OF STRAIN INDUCED NANOSCALE SELF-ASSEMBLY FROM ATOMIC-SCALE

STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS

REGIONAL AND URBA SEISMIC MONITORING: WASATCH FRONT, UTAH, AND NEIGHBORING INTERMOUNTAIN WEST REGION

METABOLIC IMPACT AND MECHANISM OF ENHANCED MITOCHONDRIAL CALCIUM UPTAKE IN MITOCHONDRIAL CARDIOMYOPATHIES

QUALITY CONTROL OF MITOCHONDRIAL NUTRIENT TRANSPORTERS

PREDICTION OF SUICIDE DEATH USING EHR AND POLYGENIC RISK SCORES

LONGITUDINAL MODELS OF BREAST CANCER FOR STUDYING MECHANISMS OF THERAPY RESPONSE AND RESISTANCE

CIRC: ENS/GRAND: POWDER-ENS - ENHANCING AND SUSTAINING THE POWDER PLATFORM -THE POWDER PLATFORM IS A WIRELESS ?LIVING LABORATORY?, IN SALT LAKE CITY, UTAH, THAT ENABLES RESEARCH THAT ACCELERATES THE REALIZATION OF NEW TECHNOLOGIES, SERVICES AND APPLICATIONS RELATED TO NEXT GENERATION (NEXTG) MOBILE NETWORKS. A ?LIVING LABORATORY? MEANS THAT IT IS IN THE REAL WORLD (WITH RADIOS AND OTHER DEVICES DEPLOYED ACROSS THE UNIVERSITY OF UTAH CAMPUS AND PARTS OF SALT LAKE CITY), BUT AT THE SAME TIME IS A LABORATORY WHERE RESEARCHERS CAN DO EXPERIMENTS (DO MEASUREMENTS, TEST NEW PROTOCOLS AND APPLICATIONS, ETC.) ONE OF THE UNIQUE CAPABILITIES OF THE POWDER PLATFORM IS THAT IT IS FULLY REMOTELY ACCESSIBLE, WHICH MEANS THAT RESEARCHERS FROM ANYWHERE IN THE WORLD CAN PERFORM EXPERIMENTS ON IT. POWDER?S MOST UNIQUE CAPABILITIES ARE ITS EXTENSIVE OVER-THE-AIR (OTA) OPERATION IN A REAL WORLD ENVIRONMENT, WITH A FULLY PROGRAMMABLE END-TO-END INFRASTRUCTURE, MOBILE ENDPOINTS AND FULLY OPERATIONAL OPEN-SOURCE NEXTG STACKS. THE POWDER-ENS PROJECT BUILDS ON THE SUCCESS OF THE POWDER PLATFORM BY ENHANCING ITS CAPABILITIES TO FIT EMERGING TECHNOLOGY TRENDS AND RESEARCH INTERESTS. POWDER-ENS SPECIFICALLY FOCUSES ON PROVIDING CAPABILITIES TO SUPPORT RESEARCH IN THE EMERGING AREA OF OPEN RADIO ACCESS NETWORKS (OPEN RAN OR O-RAN), DEVELOPING TOOLS AND DATASETS TO ENABLE MOBILE AND WIRELESS RESEARCH, AND DEVELOPING TOOLS, WORKFLOWS AND END-TO-END USE CASES RELATED TO THE USE OF ARTIFICIAL INTELLIGENCE (AI) AND MACHINE LEARNING (ML) IN MOBILE AND WIRELESS RESEARCH. THE IMPORTANCE OF MOBILE AND WIRELESS SERVICES AND TECHNOLOGIES TO SOCIETY AS A WHOLE CANNOT BE OVERSTATED. THE RESEARCH ENABLED BY THE PROJECT WILL RESULT IN NEW SERVICES AND APPLICATIONS OVER NEXTG NETWORKS WITH THE POTENTIAL TO BRING ENORMOUS BENEFITS TO SOCIETY. MOBILE AND WIRELESS RELATED SKILL SETS, KNOWHOW AND INNOVATION ARE CRITICALLY IMPORTANT FROM US ECONOMIC AND NATIONAL SECURITY PERSPECTIVES. THE PROJECT CONTRIBUTES TO THIS, NOT ONLY IN THE RESEARCH IT ENABLES, BUT NOTABLY, THROUGH ITS REMOTE ACCESS CAPABILITIES, IN ?DEMOCRATIZING? ACCESS TO SOPHISTICATED RESEARCH INFRASTRUCTURE AND THUS BROADENING RESEARCH AND WORKFORCE DEVELOPMENT ALIKE. BROADENING ACCESS TO SOPHISTICATED RESEARCH FACILITIES PROVIDED BY POWDER AND ENABLING TRAINING IN THE INHERENTLY CROSS-DISCIPLINARY MOBILE AND WIRELESS DOMAIN ARE KEY OBJECTIVES FOR THE PROJECT. THE POWDER PORTAL WEBSITE AND PLATFORM PORTAL CAN BE ACCESSED AT: HTTPS://WWW.POWDERWIRELESS.NET/ THE WEBSITE PROVIDES GENERAL INFORMATION ABOUT THE FACILITY, HARDWARE AND SOFTWARE CAPABILITIES AVAILABLE ON THE PLATFORM, POINTERS TO DATASETS CREATED ON THE PLATFORM, NEWS ABOUT PROJECT AND PLATFORM ACTIVITIES AND MORE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

MODELING SPECTRA OF 160,000 BOSS QUASARS FOR LYMAN ALPHA STUDIES

ROBUST SOFTWARE TOOLS FOR VARIANT IDENTIFICATION AND FUNCTIONAL ASSESSMENT

PARALLEL PATHWAYS IN VISUAL CORTEX: FUNCTIONAL CONNECTIVITY OF OUTPUT PATHWAYS FR

MODELING AND SIMULATION TO SUPPORT EPIDEMIOLOGICAL DECISION-MAKING IN HEALTHCARE SETTINGS

STRUCTURE AND DYNAMICS OF MEIOTIC CHROMOSOMES

MOLECULAR MECHANISMS OF WNK-SPAK/OSR1 REGULATION OF TRANSEPITHELIAL ION TRANSPORT IN THE DROSOPHILA RENAL TUBULE

BIOLOGICAL FATE AND BIOCOMPATABILITY OF DENDRITIC AND SILICA-BASED NANOCONSTRUCTS

PD-CATALYZED OLEFIN FUNCTIONALIZATION REACTIONS FOR ORGANIC SYNTHESIS

DEVELOPMENT OF A RELOADABLE ANTIMICROBIAL POUCH TO PREVENT BIOFILM IMPLANT RELATED INFECTION

MULTIDISCIPLINARY PULMONARY AND CRITICAL CARE RESEARCH TRAINING PROGRAM

TELEPHONE LINKED CARE: AN IT ENABLED INTEGRATED SYSTEM FOR CANCER SYMPTOM RELIEF

OPTIMIZING REHABILITATION INTERVENTIONS (ORION) FOR COGNITION FOLLOWING COMPLEX TRAUMATIC BRAIN INJURY.

ELIMINATING TOBACCO-RELATED DISPARITIES AMONG AFRICAN AMERICAN SMOKERS

DYADIC SLEEP, BIOBEHAVIORAL RHYTHMS AND COGNITIVE FUNCTION IN OLDER ADULTS: IMPLICATIONS FOR ALZHEIMER?S DISEASE - ABSTRACT INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT (MCI) DEMONSTRATE COGNITIVE DECLINE WITHOUT MAJOR FUNCTIONAL IMPAIRMENT BUT ALSO EXPERIENCE A 7-FOLD INCREASED RISK FOR DEVELOPING ALZHEIMER’S DISEASE, A LEADING CAUSE OF POORER QUALITY OF LIFE (QOL), PREMATURE MORTALITY, AND HEALTH CARE EXPENDITURES. SLEEP AND BIOBEHAVIORAL RHYTHM DISTURBANCES (DISRUPTIONS IN 24H OSCILLATIONS IN PHYSIOLOGY AND BEHAVIOR, INCLUDING REST-ACTIVITY PATTERNS AND MEALTIMES) ARE MORE THAN TWICE AS COMMON AMONG PATIENTS WITH MCI THAN COGNITIVELY INTACT OLDER ADULTS. EMERGING EVIDENCE DEMONSTRATES A MECHANISTIC ROLE OF SLEEP AND BIOBEHAVIORAL RHYTHM DISTURBANCES IN COGNITIVE DECLINE AND THE DEVELOPMENT AND PROGRESSION OF ALZHEIMER’S DISEASE. IMPORTANTLY, THE CONSEQUENCES OF SLEEP AND BIOBEHAVIORAL RHYTHM DISRUPTION IN MCI EXTEND BEYOND THE PATIENT, ALSO AFFECTING THE SPOUSE/PARTNER, AS SLEEP IS A “SHARED” HEALTH BEHAVIOR FOR MOST ADULTS. HOWEVER, SLEEP AND BIOBEHAVIORAL RHYTHMS ARE TYPICALLY CONSIDERED AT THE LEVEL OF THE INDIVIDUAL. BUILDING ON OUR TEAM’S PIONEERING WORK ON SLEEP AS A SHARED EXPERIENCE AMONG COUPLES, WE PROPOSE TO INVESTIGATE SLEEP AND BIOBEHAVIORAL RHYTHMS AS FUNDAMENTAL DYADIC PROCESSES THAT CONTRIBUTE TO THE HEALTH AND COGNITIVE FUNCTIONING OF INDIVIDUALS WITH MCI OR MILD AD AND THEIR PARTNERS. WE WILL EVALUATE THE DAILY AND LONGITUDINAL EFFECTS OF TWO DYADIC PROCESSES IN SLEEP: INTERDEPENDENCE (PARTNERS’ SLEEP PATTERNS INFLUENCE ON EACH OTHER) AND CONCORDANCE (I.E., THE COUPLES’ SIMILARITY IN REST/ACTIVITY AND SOCIAL RHYTHMS SUCH AS MEAL TIMING). WE WILL CONDUCT A 14-DAY NATURALISTIC STUDY PROTOCOL IN ORDER TO EXAMINE THE MECHANISTIC ASSOCIATIONS BETWEEN SLEEP AND BIOBEHAVIORAL RHYTHMS AND PROXIMAL INDICATORS OF DAYTIME FUNCTIONING, WITHIN A SAMPLE OF 170 COUPLES IN WHICH ONE PARTNER EVIDENCES COGNITIVE IMPAIRMENT (MCI TO MILD ALZHEIMER’S DISEASE). DURING THE NATURALISTIC STUDY PROTOCOL, WE WILL CAPTURE SLEEP AND BIOBEHAVIORAL RHYTHMS VIA OBJECTIVE (ACTIGRAPHY) MEASURES OF SLEEP AND CIRCADIAN REST-ACTIVITY RHYTHMS AND DAILY SOCIAL RHYTHMS, RESPECTIVELY. ALSO, WE WILL INCLUDE DAILY ASSESSMENTS OF MOOD AND RELATIONSHIP QUALITY, AND WE WILL USE AN INNOVATIVE SMARTPHONE COGNITIVE ASSESSMENT THAT HAS BEEN VALIDATED TO MEASURE COGNITIVE FUNCTION IN DAILY LIFE. IN ADDITION, WE WILL CONDUCT COMPREHENSIVE NEUROPSYCHOLOGICAL ASSESSMENTS AT BASELINE AND AGAIN AT TWO-YEAR FOLLOW-UP TO EXAMINE HOW SLEEP AND BIOBEHAVIORAL RHYTHM DISRUPTIONS AT BASELINE PREDICT COGNITIVE DECLINE OVER 2 YEARS IN BOTH PARTNERS. RESULTS OF STUDY WILL ADVANCE THE UNDERSTANDING OF THE DAILY AND LONGITUDINAL RELATIONSHIPS BETWEEN THE INDIVIDUAL AND COUPLE-LEVEL PROCESSES IN SLEEP AND BIOBEHAVIORAL RHYTHMS THAT INFLUENCE THE PROGRESSION OF COGNITIVE DECLINE IN A POPULATION AT INCREASED RISK FOR DEVELOPING ALZHEIMER’S DISEASE.

CERAMIDES AS NOVEL DRIVERS OF METABOLIC DYSFUNCTION AND COLORECTAL CANCER - SUMMARY IN RESPONSE TO THE BURGEONING WORLDWIDE OBESITY PANDEMIC, THE RATE OF OBESITY-ASSOCIATED COLORECTAL CANCER (CRC) REMAINS AN ENORMOUS PUBLIC HEALTH BURDEN. THE METABOLIC DETERMINANTS OF CRC ARE COMPLEX AND REMAIN UNDER DEBATE. CERAMIDES ARE PATHOGENIC LIPIDS THAT SIGNAL A STATE OF NUTRITION EXCESS AND ACCUMULATE IN ORGANS THAT ARE NOT SUITED FOR FAT STORAGE, DRIVING INSULIN RESISTANCE AND DYSLIPIDEMIA. OUR PRELIMINARY DATA ALSO DEMONSTRATE THAT CERAMIDES ARE CRITICAL INTERMEDIATES LINKING NUTRITIONAL INPUTS LIKE FATTY ACIDS TO INTESTINAL STEM CELL PROLIFERATION. OUR LONG-TERM GOAL IS TO UNDERSTAND THE ROLE OF CERAMIDE METABOLISM IN THE DEVELOPMENT OF CRC AND TO IDENTIFY PHARMACOLOGIC AND DIETARY STRATEGIES TO INTERVENE UPON CERAMIDE METABOLISM FOR CANCER PREVENTION. OUR CENTRAL HYPOTHESIS IS THAT CERAMIDE METABOLISM IS A KEY COMPONENT OF METABOLIC DYSREGULATION UNDERLYING CRC. WE PROPOSE A TRANSDISCIPLINARY COLLABORATION, UTILIZING EPIDEMIOLOGIC AND CLINICAL COHORTS AND ANIMAL EXPERIMENTS, TO CONDUCT SYNERGISTIC ANALYSES AND INTERVENTIONS TO ADDRESS OUR HYPOTHESIS. IN AIM 1A, USING A RIGOROUS DISCOVERY-REPLICATION DESIGN, WE WILL CHARACTERIZE A CERAMIDE-BASED CRC RISK SCORE IN SERUM FROM PARTICIPANTS IN THE EUROPEAN PROSPECTIVE INVESTIGATION INTO CANCER AND NUTRITION (EPIC) (N=1260CASES/1260 CONTROLS), AND THE PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCER COHORT (N=1234 CASES/1234 CONTROLS), AND IDENTIFY A DIETARY PATTERN STRONGLY LINKED TO CERAMIDES. IN AIM 1B, WE WILL DETERMINE THE EFFECTS OF MEDICAL AND SURGICAL WEIGHT LOSS AND CHANGES IN BODY COMPOSITION ON THE CERAMIDE CRC RISK SCORE IN OUR ONGOING UTAH BARIATRIC SURGERY COHORT. IN AIM 1C, WE WILL MEASURE THE ASSOCIATION OF GENETICALLY PREDICTED LEVELS OF CIRCULATING CERAMIDES WITH RISK OF CRC USING DATA FROM 57,873 CRC CASES AND 67,087 CONTROLS IN THE GENETICS AND EPIDEMIOLOGY OF CRC CONSORTIUM (GECCO), AND TEST FOR GENE BY DIETARY PATTERN INTERACTION. IN AIM 2, WE WILL DETERMINE WHETHER SYSTEMIC OR TISSUE-SPECIFIC REDUCTION OF CERAMIDES AFFECTS CRC DEVELOPMENT. WE WILL IMPEDE CERAMIDE SYNTHESIS BY INHIBITING DIHYDROCERAMIDE DESATURASE-1 (DES1) ACTION GENETICALLY (AIM 2A) AND PHARMACOLOGICALLY (AIM 2B), AND VIA A SERINE OR TIME RESTRICTED DIETARY PATTERN (AIM 2C), TO TEST FOR EFFECTS ON GUT, LIVER AND ADIPOSE DEPOTS AND COLORECTAL TUMOR INCIDENCE IN AN AZOXYMETHANE MOUSE MODEL OF CRC. THE STUDY LEVERAGES A NEW CLASS OF DES1 INHIBITORS THAT LOWER TISSUE CERAMIDES AND AMELIORATE THE PATHOGENIC CONSEQUENCES OF OBESITY. THE PROPOSED STUDY FILLS A MAJOR GAP IN EVIDENCE FOR UNDERSTANDING HOW CERAMIDES CONTRIBUTE TO THE METABOLIC DYSREGULATION UNDERLYING CRC. WE PROPOSE A FULLY TRANSLATIONAL APPROACH INTEGRATING EPIDEMIOLOGIC ASSOCIATIONS BETWEEN CERAMIDES AND COLORECTAL MALIGNANCIES AND PRECLINICAL STUDIES TESTING THE UTILITY OF CERAMIDE-LOWERING INTERVENTIONS ON CANCER ENDPOINTS. FINDINGS WILL HAVE IMPORTANT IMPLICATIONS FOR UNDERSTANDING THE BIOLOGIC MECHANISMS UNDERPINNING OBESITY-ASSOCIATED METABOLIC DYSREGULATION IN CRC AND FOR IDENTIFYING NEW TARGETS FOR CRC PREVENTION.

DEVELOPMENT OF CLINICAL DECISION TOOLS FOR MANAGEMENT OF DIARRHEA OF CHILDREN IN HIGH AND LOW RESOURCE SETTINGS

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

GERIATRICS WORKFORCE ENHANCEMENT PROGRAM

ADDICTION MEDICINE FELLOWSHIP

GENETIC ANALYSIS OF HIGH-RISK UTAH SUICIDE PEDIGREES

MONITORING TUMOR SUBCLONAL HETEROGENEITY OVER TIME AND SPACE

EMOTION DYSREGULATION ACROSS GENERATIONS: IDENTIFYING EARLY DEVELOPMENTAL AND CLINICAL INDICATORS OF RISK

METABOLOMIC STRATEGIES FOR DISCOVERY AND VALIDATION OF BIOMARKERS OF COLORECTAL CANCER RECURRENCE

INSTITUTIONAL CAREER DEVELOPMENT CORE

SELF-REGULATION AND COLLABORATIVE COPING WITH TYPE 1 DIABETES OVER THE LIFE SPAN

PE METHYLATION IN SKELETAL MUSCLE ENERGY EFFICIENCY

REGIONAL AND URBAN SEISMIC MONITORING