Illuminate

SHINE WAS FOUNDED IN 2010 WITH THE GOAL OF BECOMING THE WORLD LEADER IN THE SAFE, CLEAN, AFFORDABLE PRODUCTION OF MEDICAL ISOTOPES. SINCE 2010, SHINE HAS AGGRESSIVELY PURSUED THE ESTABLISHMENT OF A DOMESTIC SOURCE OF HIGH SPECIFIC ACTIVITY MO-99 WITHOUT THE USE OF HEU TO END THE CHRONIC SHORTAGES US PATIENTS ARE EXPERIENCING.

SHINE MEDICAL TECHNOLOGIES, INC. BASE MOD: FULLY FUNDS ALL 3 YEARS OF THE PERIOD OF PERFORMANCE.

INFANT-TODDLER COURT PROGRAM

THIS COMPETITIVE COOPERATIVE AGREEMENT FOR A RESEARCH AND DEVELOPMENT PROJECT ENTITLED, ''REDUCE: RECOVER ELEMENTS - DESTROY UNDESIRABLES - CREATE ENERGY'' IS AWARDED TO SHINE TECHNOLOGIES, LLC UNDER ARPA-E FOA NUMBER DE-FOA-0003418 (NEWTON) AND CONTROL NUMBER 3418-1502. THE PURPOSE OF THIS AWARD IS TO DESIGN, SIMULATE, AND LABORATORY TEST GAME-CHANGING TECHNOLOGIES THAT REDUCE THE ENVIRONMENTAL IMPACT OF NUCLEAR ENERGY GENERATION THROUGH THE RECYCLING AND TRANSMUTATION OF UNF. THE PROPOSED APPROACH WILL REDUCE THE VOLUME, LONGEVITY, AND HAZARD LEVEL OF REACTOR WASTE, AND WILL IMPROVE REPROCESSING/TRANSMUTATION ECONOMICS VIA VALUE-ADDED ISOTOPE EXTRACTION AND ENERGY SALES.

THIS PROGRAM SUPPORTS PROJECTS THAT FURTHER THE MISSION OF THE NATIONAL PARK SERVICE AND EFFORTS IN NATURAL AND CULTURAL RESOURCE CONSERVATION, PROTECTION, AND ENVIRONMENTAL SUSTAINABILITY THAT ARE NOT COVERED UNDER OTHER SPECIFIC FINANCIAL ASSISTANCE PROGRAMS. THE NATIONAL PARK SERVICE AND OLD NORTH FOUNDATION WORK TOGETHER TO PRESERVE THE INTEGRITY OF OLD NORTH CHURCH, A NATIONAL HISTORIC LANDMARK DESIGNATED BY CONGRESS FOR INCLUSION WITHIN BOSTON NATIONAL HISTORICAL PARK, AS A HISTORIC STRUCTURE FOR THE BENEFIT OF THE AMERICAN PEOPLE. BENEFICIARIES INCLUDE PROFIT ORGANIZATIONS, PUBLIC NONPROFIT INSTITUTIONS ORGANIZATIONS, PRIVATE NONPROFIT INSTITUTIONS ORGANIZATIONS, NON-FEDERAL GOVERNMENT ENTITIES, INDUSTRY AND PUBLIC DECISION MAKERS, RESEARCH SCIENTISTS, ENGINEERS, AND THE GENERAL PUBLIC.

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM ? NEONATAL ABSTINENCE SYNDROME - RURAL COMMUNITIES OPIOID RESPONSE PROGRAM – NEONATAL ABSTINENCE SYNDROME

ILLUMINATE COLORADO / FAMILY CONNECTS COLORADO - AFTER THE BIRTH OF AN INFANT(S), THE POSTNATAL OR POSTPARTUM PERIOD IS A CRITICAL TIME, WITH THE RISK OF DEATH HIGHEST FOR BOTH MOTHER AND INFANT DURING THIS SIX-WEEK WINDOW. DURING THE POSTPARTUM TIME WHEN INFANTS’ NEEDS ARE GREATEST, THE NEW MOTHER ALSO IS MOST AT-RISK FOR POSTPARTUM DEPRESSION AND MUST OVERCOME THE PHYSICAL, SOCIAL, AND PSYCHOLOGICAL CHANGES THAT OCCUR AFTER CHILDBIRTH. A RECENT COMMUNITY ASSESSMENT CONDUCTED BY ILLUMINATE COLORADO IN JANUARY 2023, UNDERSCORED A REAL AND URGENT NEED TO IDENTIFY THE NEEDS OF ALL POSTPARTUM FAMILIES AND FAMILIES WITH NEWBORNS AND CONNECT THEM TO APPROPRIATE SERVICES. FAMILY CONNECTS IS INHERENTLY DESIGNED TO MEET THIS NEED BY INCREASING IDENTIFICATION OF FAMILY NEEDS, PROVIDING PARENTING EDUCATION AND SUPPORT, AND MAKING CONNECTIONS TO APPROPRIATE SERVICES. TO ADDRESS THIS NEED, ILLUMINATE COLORADO IS PROPOSING TO ENHANCED IMPLEMENTATION OF THE FAMILY CONNECTS MODEL BY WORKING IN BOTH THE SOCIAL AND COMMUNITY CONTEXT DOMAIN AND THE HEALTH CARE QUALITY AND ACCESS DOMAIN TO IMPACT THE FOLLOWING LEADING HEALTH INDICATORS (LHIS): REDUCE THE RATE OF INFANT DEATHS – MICH-02 REDUCE MATERNAL DEATHS – MICH-04 ULTIMATELY, THE PROPOSED PROJECT GOAL IS TO REDUCE MATERNAL AND INFANT DEATHS BY ENSURING MORE COLORADO POSTPARTUM FAMILIES HAVE CULTURAL AND LINGUISTIC ACCESS TO THE UNIVERSAL FAMILY CONNECTS MODEL, ENSURING LINKAGES RELATED TO THE DRIVERS OF MATERNAL AND INFANT MORTALITY OCCUR DURING FAMILY CONNECTS VISITS, AND REDUCING EXISTING RACIAL/ETHNIC AND LANGUAGE DISPARITIES IN POSTPARTUM SDOH-RELATED INDICATORS. BY FOCUSING ON THIS GOAL, THE PROJECT WILL CONTRIBUTE TO THE GROWING BODY OF EVIDENCE RELATED TO HOW FAMILY CONNECTS CAN ADDRESS DISPARITIES IN MATERNAL AND INFANT MORTALITY., AS REFLECTED IN THE ACCOMPANYING LOGIC MODEL, THE THREE OBJECTIVES ARE CRAFTED TO CONTRIBUTE TO THIS BROADER PROJECT GOAL OF PREVENTING MATERNAL AND INFANT MORTALITY. OBJECTIVE 1: BY SEPTEMBER 2028, INCREASE ACCESS AND UTILIZATION OF FAMILY CONNECTS IN COLORADO BY USING FAMILY AMBASSADORS THAT REFLECT POPULATIONS CURRENTLY UNDERREPRESENTED IN SERVICE UTILIZATION (INCLUDING BUT NOT LIMITED TO PEOPLE WHO IDENTIFY AS BLACK, SPANISH-SPEAKING, INDIGENOUS/NATIVE AMERICAN). OBJECTIVE 2: BY SEPTEMBER 2028, REDUCE INFANT DEATHS AND MATERNAL DEATHS BY ENSURING SCREENING, EDUCATION, AND INDICATED REFERRALS RELATED TO THE DRIVERS OF MATERNAL AND INFANT MORTALITY TAKE PLACE AS PART OF FAMILY CONNECTS IMPLEMENTATION. OBJECTIVE 3: BY SEPTEMBER 2028 AND BY WORKING IN BOTH THE SOCIAL/COMMUNITY CONTEXT DOMAIN AND THE HEALTH CARE QUALITY AND ACCESS DOMAIN, REDUCE EXISTING RACIAL/ETHNIC AND LANGUAGE DISPARITIES IN POSTPARTUM INDICATORS.

POTENTIAL TECHNIQUES FOR KRYPTON AND XENON CAPTURE PROCESSING AND STORAGE IN SOLID MATRICES

ENHANCING COMMUNITY SUPPORT FOR COLORADO CHILDREN AND YOUTH VICTIMS OF THE OPIOID CRISIS

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM ? NEONATAL ABSTINENCE SYNDROME

CPD

SBIR PHASE I: THE LADDR PLATFORM FOR PRECISE DELIVERY OF NUCLEIC ACID THERAPY FOR HEAD AND NECK CANCER AND ESOPHAGEAL CANCER -THE BROADER IMPACT/COMMERCIAL POTENTIAL OF THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE I PROJECT IS IN THE DEVELOPMENT OF ILLUMINATE THERAPEUTICS? LIGHT ACTIVATED DRUG DELIVERY AND RELEASE (LADDR) PLATFORM TECHNOLOGY TO IMPROVE PATIENT OUTCOMES IN HEAD AND NECK (H&N) AND ESOPHAGEAL CANCER TREATMENT. H&N AND ESOPHAGEAL CANCERS ARE SOME OF THE MOST COMMON CANCERS WORLDWIDE AND MAKE UP 4.5% OF ALL NEW CANCER CASES IN THE US. OVER 60,000 CASES OF H&N CANCER AND OVER 20,000 CASES OF ESOPHAGEAL CANCER ARE NEWLY DIAGNOSED IN THE US EACH YEAR. THE TOTAL MARKET FOR H&N CANCER TREATMENT IS ~$1.2 BILLION IN 2021, WITH A CAGR OF 12.5% DURING THE FORECAST PERIOD. THE ESOPHAGEAL CANCER MARKET IS SIMILARLY SIZED, WITH THE MARKET VALUED AT $1.14 BILLION IN 2021, AND IT IS EXPECTED TO GROW AT A CAGR OF 8.50%. THE LADDR PLATFORM ENABLES PRECISE SPATIOTEMPORAL DELIVERY OF SMALL THERAPEUTIC RNAS TO TUMORS BY A COMBINATION OF NANOPARTICLE-MEDIATED DELIVERY AND ACTIVATION TRIGGERED BY EXTERNAL LIGHT. THE USE OF LADDR WITH MICRORNA MIMICS IN THE TREATMENT OF CANCER WILL PRESERVE HEALTHY TISSUES, MAINTAINING CRITICAL TISSUE FUNCTION WHILE ELIMINATING THE COMMON SIDE EFFECTS ASSOCIATED WITH CURRENT STANDARD-OF-CARE TREATMENTS. THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE I PROJECT IS CRUCIAL TO THE COMMERCIALIZATION OF THE LADDR TECHNOLOGY BY DERISKING TWO MAJOR POTENTIAL ISSUES: 1) PREDICTING RESPONSIVE AND NON-RESPONSIVE TUMORS AND 2) DETERMINING THE IMPACT OF ROUTE OF ADMINISTRATION ON LADDR?S BASIC PHARMACOKINETIC/DYNAMIC PROPERTIES. THE KEY OBJECTIVES IN THIS STUDY ARE TO: 1) IDENTIFY MICRORNA-MIMIC-RESPONSIVE AND NON-RESPONSIVE PATIENT-DERIVED TUMORS, 2) SELECT THE PREDICTIVE MARKERS FOR RESPONSIVE TUMORS, AND 3) DETERMINE THE BASIC PHARMACOKINETICS AND PHARMACODYNAMICS OF THE LADDR VEHICLE FOR DELIVERING FUNCTIONAL MICRORNA MIMICS TO TUMORS IN VIVO. THE RESEARCH IS SEPARATED INTO TWO OBJECTIVES. OBJECTIVE 1 WILL DETERMINE THE BREADTH OF EACH MICRORNA MIMIC?S ACTIVITY IN REPRESENTATIVE PATIENT-DERIVED TUMOR ORGANOIDS DERIVED FROM H&N AND ESOPHAGEAL CANCERS AND IDENTIFY BIOMARKERS OF RESPONSIVE AND NON-RESPONSIVE TUMORS FOR THE DEVELOPMENT OF PERSONALIZED THERAPIES. OBJECTIVE 2 WILL DETERMINE THE IMPACT OF THE ROUTE ON LADDR?S BASIC PHARMACOKINETIC/DYNAMIC PROPERTIES. THE INSIGHT GAINED IN THIS STUDY WILL ALLOW THE IDENTIFICATION OF THE FUNCTIONAL TARGETS OF MICRORNA MIMICS IN H&N AND ESOPHAGEAL TUMORS AND PROVIDE A PROOF-OF-CONCEPT FOR THERAPEUTIC MICRORNA MIMIC DELIVERY USING LIGHT-ACTIVATED LADDR VEHICLES IN VIVO. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

NPS-FY21-NER-1-NPS CONSERVATION, PROTECTION, OUTREACH, AND EDUCATION

FAMILY CONNECTS COLORADO

PRESENTING THE BLACK EXPERIENCE AT OLD NORTH CHURCH & HISTORIC SITE [THIS PROJECT WILL EQUIP ONF WITH THE RESOURCES NEEDED TO? RESEARCH, DOCUMENT, AND INTERPRET THE EXPERIENCES OF OLD NORTH?S FREE AND ENSLAVED BLACK CONGREGANTS, AS WELL AS OUR SITE'S COMPLEX INVOLVEMENT IN THE TRADE OF ENSLAVED AFRICANS, AS A FULLY INTERWOVEN PART OF SITE INTERPRETATION] [PURPOSE:?DEVELOPMENT OF A NEW INTERPRETIVE PLAN THAT IS INCLUSIVE OF THE BLACK EXPERIENCE AT OLD NORTH CHURCH.  ACTIVITIES TO BE PERFORMED: OLD NORTH WILL HIRE A MANAGER, CONTRACT WITH A CURRICULUM DEVELOPMENT CONSULTANT, AND CONVENE AN ADVISORY TEAM. THEY WILL REVIEW ARCHIVAL COLLECTIONS AND CONDUCT RESEARCH, REIMAGINE THE CHURCH?S INTERPRETIVE PLAN, REFINE EXHIBITION CONTENT AND CURRICULA, AND OFFER A MONTHLY SPEAKER SERIES.  EXPECTED OUTCOMES:?PRODUCTION OF A NEW TRAINING GUIDE FOR ONSITE EDUCATORS, AN ONLINE EXHIBIT, AND MULTIDISCIPLINARY CURRICULA FOR K-12 CLASSROOMS. OLD NORTH WILL PRESENT A MORE COMPREHENSIVE ACCOUNTING OF ITS HISTORY IN PREPARATION FOR UPCOMING MILESTONE CELEBRATIONS INCLUDING ITS FOUNDING, PAUL REVERE?S RIDE, AND AMERICA?S 250TH.      INTENDED BENEFICIARIES: HISTORIC SITE VISITORS, HIGH SCHOOL HISTORY AND ENGLISH CLASSES, MIDDLE SCHOOL CLASSROOMS, AND MEMBERS OF THE PUBLIC.   SUBRECIPIENT ACTIVITIES:?THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.]

CPD-FG

15.904 HISTORIC PRESERVATION FUND GRANTS-IN-AID HISTORIC PRESERVATION FUND GRANTS-IN-AID ASSIST IN THE IDENTIFICATION, EVALUATION, AND PROTECTION OF HISTORIC PROPERTIES BY SUCH MEANS AS EDUCATION, SURVEY, PLANNING, TECHNICAL ASSISTANCE, PRESERVATION, DOCUMENTATION, AND FINANCIAL INCENTIVES LIKE GRANTS AND TAX CREDITS AVAILABLE FOR HISTORIC PROPERTIES. OPPORTUNITY P23AS00504 THE SEMIQUINCENTENNIAL GRANT PROGRAM SUPPORTS THE PHYSICAL PRESERVATION OF A BROAD VARIETY OF CULTURAL RESOURCES ASSOCIATED WITH THE FOUNDING OF AMERICA AS A NATION IN COMMEMORATION OF THE COUNTRY S SEMIQUINCENTENNIAL (250TH ANNIVERSARY). BENEFICIARIES INCLUDE STATES, TRIBES, LOCAL GOVERNMENTS, AND NONPROFITS. THESE GRANTS FUND PHYSICAL PRESERVATION FOR NATIONAL REGISTER LISTED CULTURAL RESOURCES RELATED TO THE FOUNDING OF THE NATION. THIS PROJECT IS AWARDED TO THE OLD NORTH ILLUMINATED, INC. FOR REPAIRS AND UPDATES TO INCREASE ACCESSIBILITY TO PORTIONS OF THE OLD NORTH CHURCH, IN BOSTON, MA.

BRINGING OLD NORTH TO THE 21ST CENTURY: HISTORIC PLACES PLANNING GRANT [OLD NORTH CHURCH & HISTORIC SITE REQUESTS A HISTORIC PLACES PLANNING GRANT IN THE AMOUNT OF $75,000 TO SUPPORT 1) A CAMPUS-WIDE INTERPRETIVE PLAN THAT TRACES THE THEME OF ACTIVE CITIZENSHIP FROM THE CHURCH?S FOUNDING IN 1723 TO PRESENT DAY, INCLUDING THE SEMINAL STORY OF PAUL REVERE AS WELL AS OTHER EXAMPLES OF CIVIC ENGAGEMENT; 2) A SECOND THEMATIC COMPONENT OF THE INTERPRETIVE PLAN WILL INCLUDE EXPLORATION OF THE PARADOXICAL TRUTH OF OLD NORTH?S COMPLICATED HISTORY WITH SLAVERY; AND 3) AS PART OF THE PLAN, THE DESIGN OF AN OUTDOOR EXHIBIT THAT WEAVES TOGETHER THESE THEMES THROUGH A CRITICAL EXAMINATION OF LONGFELLOW?S ?PAUL REVERE?S RIDE,? A POEM AND STORY THAT IS FAMILIAR TO MANY OF OUR GUESTS.]

THIS PROGRAM SUPPORTS PROJECTS THAT FURTHER THE MISSION OF THE NATIONAL PARK SERVICE AND EFFORTS IN NATURAL AND CULTURAL RESOURCE CONSERVATION, PROTECTION, AND ENVIRONMENTAL SUSTAINABILITY THAT ARE NOT COVERED UNDER OTHER SPECIFIC FINANCIAL ASSISTANCE PROGRAMS. THE NATIONAL PARK SERVICE AND OLD NORTH FOUNDATION WORK TOGETHER TO PRESERVE THE INTEGRITY OF OLD NORTH CHURCH, A NATIONAL HISTORIC LANDMARK DESIGNATED BY CONGRESS FOR INCLUSION WITHIN BOSTON NATIONAL HISTORICAL PARK, AS A HISTORIC STRUCTURE FOR THE BENEFIT OF THE AMERICAN PEOPLE. BENEFICIARIES INCLUDE PROFIT ORGANIZATIONS, PUBLIC NONPROFIT INSTITUTIONS ORGANIZATIONS, PRIVATE NONPROFIT INSTITUTIONS ORGANIZATIONS, NON-FEDERAL GOVERNMENT ENTITIES, INDUSTRY AND PUBLIC DECISION MAKERS, RESEARCH SCIENTISTS, ENGINEERS, AND THE GENERAL PUBLIC.

CONSERVATION, PROTECTION, OUTREACH, AND EDUCATION

PRESERVATION OF THE OLD NORTH CHURCH SELECTIVE DEMOLITION TO DETERMINE SOURCE OF WATER INFILTRATION

TO SUPPORT INNOVATIVE SCIENCE AND ENVIRONMENT FESTIVAL

PRESERVATION OF OLD NORTH CHURCH HISTORIC STRUCTURES REPORT UPDATE

PRESERVATION OF OLD NORTH CHURCH CLOUGH HOUSE ROOF REPLACEMENT

PURPOSE: TO SUPPORT SHAKESPEARE IN THE SKATE PARK.

PRESERVATION, REHABILITATION, INTERPRETATION, AND OUTREACH OF OLD NORTH CHURCH