San Jose State University Research Foundation

FOR 30 YEARS SAN JOSE STATE UNIVERSITY (SJSU) HAS PARTNERED WITH NASA AMES RESEARCH CENTER (ARC) ON COLLABORATIVE HUMAN SYSTEMS INTEGRATION RESEARCH (HSIR) THAT HAS MADE AIR AND SPACE TRAVEL MORE SAFE EFFICIENT AND RELIABLE. WE NOW PROPOSE A FIVE-YEAR RESEARCH PLAN TO BUILD UPON OUR COLLABORATIVE WORK IN THE HUMAN SYSTEMS INTEGRATION DIVISION (CODE TH) OTHER ARC DIVISIONS AND THE US MILITARY UNDER COOPERATIVE AGREEMENT NNX12AB08A. THE RESEARCH WE PROPOSE FULFILLS THE TECHNICAL AREAS PREVIOUSLY IDENTIFIED IN NASA SOLICITATION NNA11364623A THAT REMAIN RELEVANT TO THE MISSION AND STRATEGIC GOALS OF NASA AND OTHER GOVERNMENTAL ORGANIZATIONS (E.G. FAA US ARMY). THESE AREAS ARE: (1) HUMAN-AUTOMATION INTERACTION (2) HUMAN-COMPUTER INTERACTION AND (3) INDIVIDUAL- AND TEAM-PERFORMANCE FACTORS. THIS PROPOSAL WILL ALSO EXPAND UPON PREVIOUS RESEARCH BY INCORPORATING NEW EMPHASES THAT HAVE EMERGED SINCE OUR LAST PROPOSAL. THIS PROPOSAL ENCOMPASSES THE EXISTING SJSU/ARC LABORATORY ORGANIZATION AND TECHNICAL COMPETENCIES BASED ON OUR KNOWLEDGE OF NASA S PROCESSES ACQUIRED DURING OUR LONG PARTNERSHIP. WE ANTICIPATE SIGNIFICANT BENEFITS FOR NASA FROM MAINTAINING THAT PARTNERSHIP INCLUDING: (1) AN EXISTING STRONG RESEARCH AND MANAGEMENT INFRASTRUCTURE THAT WILL REMAIN ON-SITE THROUGHOUT THE AWARD PERIOD PROVIDING TIMELY AGILE AND ADAPTIVE RESPONSES TO NASAS NEEDS AND PRIORITIES; (2) LONG-TERM CONTINUITY FOR RESEARCH ACTIVITIES; (3) SHARED GOALS AND SHARED INSTITUTIONAL KNOWLEDGE; (4) KNOWN AND RESPECTED PERSONNEL WHO HAVE ESTABLISHED PRODUCTIVE WORKING RELATIONSHIPS WITH NASA SCIENTISTS AND MANAGEMENT; (5) ACADEMIC STUDENT AND PUBLIC OUTREACH PROGRAMS CREATED TO ENHANCE NASA PROJECTS DEVELOP RELEVANT WORKFORCE SKILLS AND MEET NASA S MISSION AND STRATEGIC GOALS; (6) AN EXPERIENCED MANAGEMENT TEAM WITH A STRONG FOCUS ON SUSTAINED COLLABORATION; (7) A SUPPORTIVE AND RESPONSIVE ORGANIZATION IN THE SAN JOSE STATE UNIVERSITY RESEARCH FOUNDATION (SJSURF); (8) PROVEN SUCCESSFUL PROJECT MODELS; AND (9) RESOURCE EFFICIENCIES THROUGH AVOIDANCE OF A TIME-CONSUMING AND COSTLY TRANSITION TO ANOTHER RESEARCH ORGANIZATION.

ANTICIPATED DRAMATIC INCREASES IN AIR TRAFFIC HAVE FUELED THE PLANNED CONVERSION TO THE NEXT GENERATION AIR TRANSPORTATION SYSTEM, WHICH REINVENTS AI

HUMAN SYSTEMS INTEGRATION: COLLABORATIVE HUMAN FACTORS RESEARCH TO IMPROVE THE SAFETY EFFICIENCY AND RELIABILITY OF NASAS AERONAUTICS AND SPACE MISSIONS: PHASE 2

GEAR-UP

SCIENCE ROOTS: GROWING STUDENT FUTURES THROUGH GENAI ENHANCED PROJECT-BASED LEARNING USING GREEN NINJA

THIS UNSOLICITED COOPERATIVE AGREEMENT PROPOSAL SEEKS FUNDING FOR THREE YEARS TO CONDUCT COLLABORATIVE RESEARCH BETWEEN THE U.S. ARMY AVIATION DEVELOPMENT DIRECTORATE AT NASA AMES RESEARCH CENTER AND THE DEPARTMENT OF PSYCHOLOGY AT SAN JOSE ...

FUTURE VERTICAL LIFT: COLLABORATIVE RESEARCH ON FLIGHT CONTROL AUTONOMOUS ROTORCRAFT AND HUMAN-SYSTEMS INTERFACE DESIGN: PHASE 2

MODELING AND SIMULATION OF HUMAN PERFORMANCETHE PRESENT PROPOSAL REQUESTS AN 18-MONTH CONTINUATION

THE PRESENT UNSOLICITED PROPOSAL REQUESTS FUNDING OF A THREE-YEAR COOPERATIVE AGREEMENT BETWEEN THE ARMY AEROFLIGHTDYNAMICS DIRECTORATE (AFDD) AT THE

UNIVERSITY TRANSPORTATION CENTERS

CREW FACTORS AND TEAM PERFORMANCE PHASE IITHE PRESENT PROPOSAL REQUEST THE CONTINUATION OF FUNDING

UNIVERSITY TRANSPORTATION CENTER

SAN JOSE STATE UNIVERSITY UNDERGRADUATE MBRS RISE PROGRAM

THE PRESENT UNSOLICITED PROPOSAL REQUESTS FUNDING OF A THREE-YEAR COOPERATIVE AGREEMENT BETWEEN THE ARMY AEROFLIGHTDYNAMICS DIRECTORATE (AFDD) AT THE

THE PRESENT PROPOSAL REQUESTS FUNDING OF A THREE-YEAR COOPERATIVE AGREEMENT BETWEEN THE ARMY AEROFLI

SHIP OPERATIONS R/V POINT SUR 2012 - 2016

SHIP OPERATIONS

PROJECT ENGINEERING SUCCESS: INCREASING HISPANIC STUDENT SUCCESS IN ENGINEERING AT SAN JOSE STATE UNIVERSITY, SAN JOSE CITY COLLEGE AND GAVILAN COLLEGE

RECOVERY ACT GREEN JOBS

HUMAN-SYSTEM INEGRATION TECHNOLOGIES

MARC U STAR AT SAN JOSE STATE UNIVERSITY

SAN JOSE STATE UNIVERSITY PROPOSES A MULTI-UNIVERSITY CONSORTIUM (C-STTAR) TO ESTABLISH A CLIMATE CHANGE AND EXTREMEEVENTS TRAINING AND RESEARCH (CCEETR) PROGRAM. THE PROGRAM OBJECTIVE IS TO CONDUCT, RESEARCH, EDUCATION, ANDTECHNOLOGY TRANSFER ACTIVITIES TO IMPROVE THE RAIL NETWORK S SAFETY AND RESILIENCE AGAINST EXTREME EVENTS, INCLUDING CLIMATECHANGE. THE APPLICANT WILL FOCUS ON FIVE PROJECTS DIRECTED AT EDUCATING THE RAILROAD COMMUNITY AND EVALUATING ANDDEMONSTRATING TECHNOLOGIES AND APPROACHES THAT SHOW PROMISE FOR MITIGATING THE CONSEQUENCES OF EXTREME EVENTS ONRAILROAD OPERATIONS: APPLICATION OF EMERGING TECHNOLOGIES TO CREATE EVALUATION AND SIMULATION SCENARIOS FOR RAILROAD PERSONNELTRAINING CREATION AND DELIVERY OF TRAINING PROGRAMS THAT CAN BE USED BY FREIGHT AND PASSENGER RAILROADS TO ENHANCE THEIRABILITY TO DEVELOP RESPONSE PROGRAMS TO ENHANCE RESILIENCY. DEVELOPMENT OF PREDICTIVE ASSESSMENT TOOLS TO SUPPORTDETECTION, ALERT, AND WARNING SYSTEMS PLANNING, OPERATIONS, RESPONSE, AND RECOVERY FROM EMERGENCIES AND DISRUPTIVE EVENTS ENHANCE TECHNOLOGY TRANSFER, CAREER PATHWAYS, ECONOMIC AND WORKFORCE DEVELOPMENT FOR MINORITY, SMALL BUSINESSES, ANDUNDERSERVED COMMUNITIES EVALUATION AND DEMONSTRATION OF SENSORS ON MOBILE AND FIXED PLATFORMS TO IDENTIFY RISKS FOR THENORTH AMERICAN RAIL NETWORK

THE MOTIVATION FOR THE ESTABLISHMENT OF A NASA MIRO CENTER FOR APPLIED ATMOSPHERIC RESEARCH AND EDUCATION (CAARE) AT SAN JOSE STATE UNIVERSITY (SJSU)

SAN JOSE GEAR UP COMMUNITY ACHIEVEMENT PROJECT

UNIVERSITY TRANSPORTATION CENTERS

MOBY LWN TIME-SERIES UNCERTAINTY REDUCTION AND SYSTEM ENHANCEMENTS FOR IMPROVED VICARIOUS CALIBRATION ACROSS MULTIPLE AGENCY OCEAN COLOR SATELLITE MI

UNIVERSITY TRANSPORTATION CENTER - TRANSPORTATION SYSTEMS POLICY AND MANAGEMENT

FIRST IN THE WORLD - DEVELOPMENT

UPWARD BOUND PROGRAM

STUDENT SUPPORT SERVICES- SAN JOSE STATE UNIVERSITY

ONR SHIP OPERATIONS

EMPOWERING STUDENTS TO SUCCEED IN ENGINEERING AND COMPUTER SCIENCE -THIS PROJECT WILL CONTRIBUTE TO THE NATIONAL NEED FOR SKILLED ENGINEERS AND SCIENTISTS BY SUPPORTING THE ATTRACTION, RETENTION, AND GRADUATION OF LOW-INCOME, ACADEMICALLY TALENTED, UNDERGRADUATE STUDENTS IN SOFTWARE ENGINEERING, COMPUTER ENGINEERING, AND COMPUTER SCIENCE AT SAN JOS? STATE UNIVERSITY (SJSU). LED BY A COLLABORATIVE TEAM OF FACULTY IN ENGINEERING, THE SCIENCES, AND SOCIOLOGY, THE PROJECT WILL PROVIDE TWO CONSECUTIVE SUMMER ENRICHMENT PROGRAMS STARTING WHEN STUDENTS ARE HIGH SCHOOL SENIORS, AND CONTINUES WITH ACADEMIC SUPPORT, ENGAGEMENT ACTIVITIES, PAID RESEARCH OPPORTUNITIES, AND SCHOLARSHIPS THROUGHOUT THE STUDENTS? UNDERGRADUATE CAREERS. THE ELEMENTS OF THE PROJECT ARE DESIGNED TO INCREASE STUDENTS? SENSE OF BELONGING, FACILITATE COMMUNITY ENGAGEMENT VIA A ROBUST NETWORK OF FACULTY, STAFF, PEERS, AND SILICON VALLEY TECHNOLOGY PROFESSIONALS, AND STRENGTHEN STUDENTS? MATHEMATICS, PHYSICS, AND PROGRAMMING SKILL SETS BY EMPLOYING ACTIVE LEARNING, CULTURALLY RELEVANT, AND INCLUSIVE PEDAGOGICAL APPROACHES. THE PROJECT WILL BE DESIGNED TO INCREASE STUDENT BELONGING IN TECHNOLOGY VIA CONVERSATIONS ABOUT GROWTH MINDSET AND OTHER METACOGNITIVE TOOLS. THIS APPROACH WILL BE UNDERPINNED BY A FOCUS ON COMMUNITY ENGAGEMENT, TECHNICAL SKILLS, AND ACADEMIC ENVIRONMENT SUPPORT VIA SCAFFOLDING AND INFORMATIONAL SESSIONS ABOUT HIGHER EDUCATION PROCESSES AIMED AT BUILDING FAMILIARITY AND COMFORT IN THE COLLEGE ENVIRONMENT. RESEARCH WILL GENERATE KNOWLEDGE ABOUT ACADEMIC SUCCESS AND CAREER PATHWAYS FOR LOW-INCOME, ACADEMICALLY TALENTED, STUDENTS AND SERVE AS A TEMPLATE FOR THE CALIFORNIA STATE UNIVERSITY SYSTEM, AND FOR POSTSECONDARY INSTITUTIONS NATIONWIDE. THIS PROJECT IS FUNDED BY NSF?S SCHOLARSHIPS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS PROGRAM, WHICH SEEKS TO INCREASE THE NUMBER OF LOW-INCOME ACADEMICALLY TALENTED STUDENTS WITH DEMONSTRATED FINANCIAL NEED WHO EARN DEGREES IN STEM FIELDS. IT ALSO AIMS TO IMPROVE THE EDUCATION OF FUTURE STEM WORKERS, AND TO GENERATE KNOWLEDGE ABOUT ACADEMIC SUCCESS, RETENTION, TRANSFER, GRADUATION, AND ACADEMIC/CAREER PATHWAYS OF LOW-INCOME STUDENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

SOCIAL WORK HIGHER EDUCATION ALLIANCE PROGRAM (SWHEAP)

AI IS ONLY AS GOOD AS ITS USERS: ADVANCING STUDENTS' INFORMED USE OF AI IN HIGHER EDUCATION

STUDENT SUPPORT SERVICES PROGRAM

STRENGTHENING INSTITUTIONS PROGRAM (SIP)

ASIAN AMERICAN AND NATIVE AMERICAN PACIFIC ISLANDER-SERVING INSTITUTIONS PROGRAM

STUDENT SUPPORT SERVICES PROGRAM

SPARTAN SPARK: STIMULATING PASSION, ADVANCEMENT, RESEARCH, AND KNOWLEDGE FOR NEXT-GENERATION ENGINEERS IN ADVANCED ENERGY SYSTEMS

IMPROVING RETENTION THROUGH STUDENT LEARNING COMMUNITIES

NATIONAL TRANSPORTATION SECURITY CENTER OF EXCELLENCE

GEOSCIENCE FOR SOCIETY: PREPARING STUDENTS FOR CAREERS IN CLIMATE, CLEAN ENERGY, AND RESOURCE MANAGEMENT -THIS PROJECT WILL CONTRIBUTE TO THE NATIONAL NEED FOR WELL-EDUCATED SCIENTISTS, MATHEMATICIANS, ENGINEERS, AND TECHNICIANS BY SUPPORTING THE RETENTION AND GRADUATION OF HIGH-ACHIEVING, LOW-INCOME STUDENTS WITH DEMONSTRATED FINANCIAL NEED AT SAN JOSE STATE UNIVERSITY (SJSU). SJSU IS A MINORITY-SERVING INSTITUTION (MSI), AN ASIAN AMERICAN AND NATIVE AMERICAN PACIFIC ISLANDER-SERVING INSTITUTION (AANAPISI), AND A HISPANIC SERVING INSTITUTION (HSI). THE PROJECT WILL ALSO ENGAGE STUDENTS FROM EAST SIDE UNION HIGH SCHOOL DISTRICT (ESUHSD), WITH A PREDOMINANTLY HISPANIC POPULATION. OVER ITS 6-YEAR DURATION, THIS TRACK 2 PROJECT WILL FUND SCHOLARSHIPS TO 30 UNIQUE FULL-TIME SJSU STUDENTS WHO ARE PURSUING BACHELOR'S DEGREES IN GEOLOGY AND EARTH SYSTEM SCIENCE. SIX FIRST-YEAR STUDENTS WILL RECEIVE 4-YEAR SCHOLARSHIPS, AND 24 TRANSFER STUDENTS WILL RECEIVE 2-YEAR SCHOLARSHIPS OVER THE DURATION OF THE PROGRAM. SIXTY ESUHSD STUDENTS WILL BE FUNDED TO PARTICIPATE IN A 10-DAY GEOSCIENCE EXPERIENCE PROGRAM AND HUNDREDS OF ESUHSD STUDENTS WILL BE INTRODUCED TO EARTH SCIENCE CONCEPTS THROUGH REGIONAL FIELD TRIPS. THE PROJECT WILL FOSTER STUDENT COHORTS THROUGH WORKSHOPS, TUTORING, AND MENTORING TO DEVELOP STUDENTS' ACADEMIC AND PERSONAL MANAGEMENT SKILLS. RESEARCH AND SERVICE-LEARNING PROJECTS WILL INCREASE STUDENTS' BELIEF IN THEIR CAPABILITIES, WHILE IMPROVING THEIR PROFESSIONAL SKILL SET FOR CAREER READINESS, AND INCREASING STUDENTS' ENTRY INTO EXTERNAL INTERNSHIPS AND GEOSCIENCE JOBS. STUDENT-LED SERVICE-LEARNING OPPORTUNITIES WILL ENGAGE THE BROADER COMMUNITY WITH GEOSCIENCE AND SUSTAINABILITY TOPICS. THE OVERALL GOAL OF THIS PROJECT IS TO INCREASE STEM DEGREE COMPLETION OF HIGH-ACHIEVING, LOW-INCOME UNDERGRADUATES WITH DEMONSTRATED FINANCIAL NEED. THERE ARE TWO SPECIFIC AIMS: 1. INCREASE ENROLLMENT, RETENTION, AND GRADUATION RATES IN TWO GEOLOGY BS DEGREES AT SJSU THROUGH FINANCIAL AID AND PROGRAM ACTIVITIES AND 2. DEVELOP STUDENT NETWORKS AND CAREER-READINESS FOR ENTRY INTO SOCIETALLY RELEVANT GEOSCIENCE JOBS. THIS PROJECT WILL ADVANCE UNDERSTANDING OF HOW PROGRAM ACTIVITIES FOR BS STUDENTS, DEVELOPED IN THE CONTEXT OF SOCIAL-COGNITIVE-CAREER THEORY, CAN BE APPLIED TO ENHANCE STUDENT OUTCOMES IN A LOW-INCOME, RACIALLY DIVERSE EDUCATION SETTING AND A COMPLEX CAREER LANDSCAPE. STUDENTS WILL DEVELOP PORTFOLIOS TO DOCUMENT THEIR CAREER AND PERSONAL SKILLS AND REFLECT ON THEIR ACCOMPLISHMENTS TO INCREASE THEIR BELIEF IN THEIR ABILITIES AS GEOSCIENTISTS, TO SET EXPECTATIONS AND GOALS, AND TO USE WHEN DEVELOPING APPLICATIONS TO GEOSCIENCE INTERNSHIPS AND JOBS. STUDENT SURVEY RESULTS, PORTFOLIO CONTENT, AND ACADEMIC DATA WILL BE USED TO EVALUATE HOW FINANCIAL-SOCIAL-ACADEMIC SUPPORT HAS IMPACTED ACADEMIC GROWTH, SENSE OF BELONGING, RESILIENCY, AND STUDENT KNOWLEDGE OF AND INTEREST IN SOCIETALLY RELEVANT GEOSCIENCE CAREERS. QUANTITATIVE ANALYSIS OF STUDENT GPAS, RETENTION RATE, GRADUATION RATES, AND THE PROPORTION OF STUDENTS ENGAGED IN RESEARCH INTERNSHIPS AND ACCEPTED TO JOBS OR CONTINUING EDUCATION WILL ADDRESS THE EFFECTIVENESS OF THE PROJECT ACTIVITIES TO DEVELOP STUDENT NETWORKS AND CAREER READINESS. RESULTS WILL BE DISSEMINATED THROUGH RELEVANT ORAL AND POSTER SESSIONS AT ACADEMIC MEETINGS, AN ACADEMIC PAPER FOR GEOSCIENCE EDUCATION, AND PRESENTATIONS AND PARTICIPATION IN EDUCATION WORKSHOPS. THIS PROJECT IS FUNDED BY NSF'S SCHOLARSHIPS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS PROGRAM, WHICH SEEKS TO INCREASE THE NUMBER OF ACADEMICALLY TALENTED, LOW-INCOME STUDENTS WITH DEMONSTRATED FINANCIAL NEED WHO EARN DEGREES IN STEM FIELDS. IT ALSO AIMS TO IMPROVE THE EDUCATION OF FUTURE STEM WORKERS, AND TO GENERATE KNOWLEDGE ABOUT ACADEMIC SUCCESS, RETENTION, TRANSFER, GRADUATION, AND ACADEMIC/CAREER PATHWAYS OF LOW-INCOME STUDENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

MODELING AND SIMULATION OF HUMAN PERFORMANCESUMMARY: THE PRESENT PROPOSAL REQUESTS THE FUNDING OF A

TRANSFORMING UNDERGRADUATE TEACHING AND LEARNING THROUGH CULTURALLY SUSTAINING, ACTIVE, AND ASSET-BASED APPROACHES TO INTRODUCTORY SCIENCE COURSES

"COMPUTATIONAL MODELS OF HUMAN WORKLOAD: DEFINITION, REFINEMENT, INTEGRATION, AND VALIDATION IN FAST-TIME NATIONAL AIRSPACE SIMULATIONS" ORIGINA

ENGLISH LANGUAGE ACQUISITION: NATIONAL PROFESSIONAL DEVELOPMENT PROGRAM

TRIO - STUDENT SUPPORT SERVICES - STUDENT SUPPORT SERVICES PROGRAM

CCAMPIS GRANT 2021-2025

CAREER EXPLORATION LAB: 3D PRINTING AND STEM ENGAGEMENT FOR HIGH SCHOOL STUDENTS WITH VISUAL IMPAIRMENTS AND THEIR EDUCATORS

THE OBJECTIVE OF THE PROPOSED RESEARCH IS TO DEVELOP SYSTEM ARCHITECTURE AND ALGORITHMS TO GENERATE

SPARTAN PHALANX: HOLISTIC, SUPPORT TO RETAIN STUDENTS ON ACADEMIC PROBATION

UNDERSTANDING TEACHER EFFECTIVENESS AND RETENTION AMONG SINGLE SUBJECT MATH PROGRAM COMPLETERS IN THE FIRST FIVE YEARS OF TEACHING -THIS PROJECT AIMS TO SERVE THE NATIONAL NEED OF DETERMINING FACTORS THAT INFLUENCE EFFECTIVENESS AND RETENTION FOR SECONDARY MATHEMATICS TEACHERS IN HIGH-NEED SCHOOL DISTRICTS. THE PROJECT AIMS TO IDENTIFY AND DESCRIBE THE ROLE OF INDIVIDUAL, INTERPERSONAL, ORGANIZATIONAL, COMMUNITY, AND POLICY FACTORS IN EARLY-CAREER SECONDARY MATHEMATICS TEACHERS? ENACTMENT OF EFFECTIVE MATHEMATICS TEACHING PRACTICES AND DECISIONS TO EITHER STAY, MOVE, OR LEAVE THE PROFESSION. DATA WILL BE COLLECTED FROM SINGLE SUBJECT CREDENTIAL PROGRAM (SSCP) MATHEMATICS COMPLETERS IN THEIR FIRST FIVE YEARS OF TEACHING IN BOTH HIGH-NEED AND NON-HIGH-NEED SCHOOL DISTRICTS IN CALIFORNIA. THE RESULTS OF THE STUDY WILL BE USED TO GENERATE RECOMMENDATIONS FOR IMPROVING AND STRENGTHENING THE CONNECTIONS BETWEEN CREDENTIAL AND INDUCTION PROGRAMS AND INITIATIVES TO SUPPORT LONG-TERM RETENTION AND EFFECTIVE, INCLUSIVE, AND EQUITABLE MATHEMATICS TEACHING PRACTICES. THIS THREE-YEAR PROJECT AT SAN JOSE STATE UNIVERSITY INCLUDES PARTNERSHIPS WITH THE FOLLOWING SEVEN CALIFORNIA STATE UNIVERSITY (CSU) CAMPUSES: CAL POLY POMONA; CSU EAST BAY; CSU LONG BEACH; CSU MONTEREY BAY; CSU SACRAMENTO; CSU SAN MARCOS; AND FRESNO STATE UNIVERSITY. A CENTRAL FOCUS OF THE PROJECT IS TO UNCOVER SUCCESSFUL PATHWAYS THAT ENABLE TEACHER CANDIDATES AND INTERNS TO MOVE FROM UNIVERSITIES INTO MIDDLE AND HIGH SCHOOLS AND TO BE RETAINED AS HIGHLY EFFECTIVE MATHEMATICS TEACHERS. THE CONCEPTUAL FRAMEWORK INCLUDES THE COMPLEX NATURE OF TEACHERS' ENACTED PRACTICES, COLLECTIVE SELF-STUDY OF TEACHING PRACTICE, AND A SOCIAL ECOLOGICAL MODEL OF FACTORS THAT CONTRIBUTE TO TEACHER RETENTION. FOUR RESEARCH QUESTIONS WILL BE ADDRESSED USING AN EXPLANATORY SEQUENTIAL MIXED METHODS DESIGN. FIRST, WHAT IS THE NATURE AND QUALITY OF SSCP MATH COMPLETERS' PROFESSIONAL EXPERIENCES IN THEIR CLASSROOMS AND WORK ENVIRONMENTS IN THE FIRST THREE YEARS OF TEACHING, AND THE VARIOUS SUPPORTS THEY RECEIVE TO BECOME EFFECTIVE, HIGHLY QUALIFIED MATHEMATICS TEACHERS? SECOND, WHAT FACTORS MOTIVATE THOSE IN THEIR FOURTH AND FIFTH YEAR OF TEACHING TO PERSIST? THIRD, WHAT FACTORS SHAPE THE DECISIONS OF THOSE WHO MOVE TO A DIFFERENT SCHOOL OR LEAVE THE TEACHING PROFESSION WITHIN THE FIRST FIVE YEARS? FOURTH, TO WHAT EXTENT ARE TEACHER CHARACTERISTICS, SCHOOL DEMOGRAPHICS, AND WORKING CONDITIONS ASSOCIATED WITH TEACHING EFFECTIVENESS AND DECISION TO STAY, MOVE, OR LEAVE? AT LEAST 500 SSCP MATHEMATICS COMPLETERS WILL BE RECRUITED TO COMPLETE A SURVEY WITH THE POSSIBILITY OF A FOLLOW-UP INDIVIDUAL INTERVIEW. THIS TRACK 4: NOYCE RESEARCH PROJECT IS SUPPORTED THROUGH THE ROBERT NOYCE TEACHER SCHOLARSHIP PROGRAM (NOYCE). THE NOYCE PROGRAM SUPPORTS TALENTED STEM UNDERGRADUATE MAJORS AND PROFESSIONALS TO BECOME EFFECTIVE K-12 STEM TEACHERS AND EXPERIENCED, EXEMPLARY K-12 TEACHERS TO BECOME STEM MASTER TEACHERS IN HIGH-NEED SCHOOL DISTRICTS. IT ALSO SUPPORTS RESEARCH ON THE EFFECTIVENESS AND RETENTION OF K-12 STEM TEACHERS IN HIGH-NEED SCHOOL DISTRICTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

UPHOLDING THE AMERICAN EXPERIENCE: FOSTERING CIVIC KNOWLEDGE & ENGAGEMENT FOR THE NEXT SEMIQUINCENTENNIAL

THIS PROJECT WILL STUDY COMMUNITY NEEDS AND USES OF FIRE WEATHER AND SMOKE INFORMATION TO INFORM THE RESPONSE TO WILDFIRES AND EVACUATION DECISIONS. THE RESEARCH WILL EXPAND ON EXISTING THEORIES AND APPROACHES TO EXPLORE PERCEPTIONS OF WILDFIRE BEHAVIOR AMONG INDIVIDUALS, AND SMOKE PREDICTIONS FOR COMMUNITIES OCCUPYING WILDFIRE-PRONE LANDSCAPES IN THE UNITED STATES. THE FOCUS WILL BE ON REGIONS WITH RECENT INCIDENCES OF EXTREME FIRE WEATHER-PRODUCING OR LARGE WILDFIRE EVENTS, WITH STUDY SITES IN CALIFORNIA, OREGON, COLORADO, AND TENNESSEE. THREE STEPS WILL BE UTILIZED DURING THE PROJECT: INTERVIEW CASE STUDIES, SURVEYS, AND AGENT-BASED MODELS TO BETTER UNDERSTAND AND INFORM RESIDENT WILDFIRE RESPONSE.

ESTABLISHING AN INDUSTRIAL ASSESSMENT CENTER AT SAN JOSE STATE UNIVERSITY

ASTRONOMICAL INFRARED BANDS AS CALIBRATED PROBES OF ASTROPHYSICALCONDITIONS IN THE JWST&#8208ERA WITH THE NASA AMES PAH IR SPECTROSCOPIC DATABASE

THE RONALD E. MCNAIR POSTBACCALAUREATE ACHIEVEMENT PROGRAM

UNIVERSITY-NATIONAL OCEANOGRAPHIC LABORATORY SYSTEM (UNOLS)

COMBINED PRIORITY FOR PERSONNEL DEVELOPMENT

COMBINED PRIORITY FOR PERSONNEL DEVELOPMENT

COMBINED PRIORITY FOR PERSONNEL DEVELOPMENT

PARTNERSHIP FOR STUDENT SUCCESS IN SCIENCE (PS3)

CREW FACTORS AND TEAM PERFORMANCETHE PRESENT PROPOSAL REQUESTS THE FUNDING OF A COOPERATIVE AGREEMEN

RONALD E. MCNAIR POSTBACCALAUREATE ACHIEVEMENT

DEVELOPING 21ST CENTURY INCLUSIVE- AND MATHEMATICAL LITERACY-DRIVEN MIDDLE SCHOOL AND HIGH SCHOOL MATHEMATICS TEACHERS: SJSU?S MATHEMATICS INTEGRATED TEACHER PREPARATION PROGRAM -THE PROJECT AIMS TO SERVE THE NATIONAL NEED OF PREPARING HIGH-QUALITY MATHEMATICS TEACHERS WHO HAVE THE KNOWLEDGE AND SKILLS TO IMPROVE MATHEMATICAL OUTCOMES FOR ALL MIDDLE AND HIGH SCHOOL STUDENTS. CURRENT APPROACHES TO PREPARING PROSPECTIVE SECONDARY MATHEMATICS TEACHERS, SUCH AS BUILDING AN EQUITY MINDSET, IMPLEMENTING CULTURALLY RELEVANT PEDAGOGY, AND DEVELOPING ACADEMIC LITERACY ARE TYPICALLY PURSUED IN SILOS. THIS PROJECT AIMS TO TRANSFORM A TRADITIONAL TEACHER CREDENTIAL PROGRAM INTO A SUBJECT MATTER-DRIVEN INTEGRATED PROGRAM IN WHICH PROSPECTIVE MATHEMATICS TEACHERS SIMULTANEOUSLY UNDERTAKE MATHEMATICS CONTENT AND MATHEMATICS SPECIFIC PEDAGOGY WHILE ALSO LEARNING EVIDENCE-BASED INTERVENTION STRATEGIES BOTH FOR TYPICALLY DEVELOPING STUDENTS AND STUDENTS WITH MILD TO MODERATE DISABILITIES. THIS APPROACH HAS THE POTENTIAL TO REVOLUTIONIZE MATHEMATICS TEACHING AND LEARNING IN HIGH-NEED URBAN SCHOOLS. CONSIDERING THE REPORTED NUMBER OF STUDENTS WHO DO NOT MEET STANDARDS IN MATHEMATICS, ESPECIALLY STUDENTS FROM CULTURALLY AND LINGUISTICALLY DIVERSE BACKGROUNDS AND WITH DISABILITIES, THIS PROJECT'S INNOVATIVE APPROACH TO MATHEMATICS TEACHER PREPARATION IS CRITICAL TO DISRUPTING THE STATUS QUO. THIS PROJECT WILL SUPPORT 30 MATHEMATICS MAJORS OVER A PERIOD OF FIVE YEARS WHO WILL DEVELOP, IMPLEMENT, AND REFINE INTEGRATED INSTRUCTIONAL PRACTICES AS THEY COMPLETE A B.A. IN MATHEMATICS WITH A MINOR IN SPECIAL EDUCATION AND A SINGLE SUBJECT CREDENTIAL IN MATHEMATICS. THIS PROJECT AT SAN JOSE STATE UNIVERSITY INCLUDES PARTNERSHIPS WITH EAST SIDE UNION HIGH SCHOOL DISTRICT AND CAMPBELL UNION SCHOOL DISTRICT. THREE GOALS GUIDE THIS PROJECT. FIRST, THE PROJECT WILL PRODUCE 30 NEW SECONDARY MATHEMATICS TEACHERS OVER FIVE YEARS WITH DEEP INTEGRATED INSTRUCTIONAL SKILLS TO SERVE THE NEEDS OF ALL STUDENTS. SECOND, THE PROJECT WILL ESTABLISH A STEM CONTENT-DRIVEN AND INTEGRATED-BY-DESIGN TEACHER PREPARATION PROGRAM. THIRD, THE INVESTIGATORS WILL IDENTIFY INTEGRATED STRATEGIES AND EXAMINE OUTCOMES OF THESE STRATEGIES FOR EFFECTIVELY IMPLEMENTING MATHEMATICAL LITERACY-DRIVEN INSTRUCTIONAL PRACTICES USING CULTURALLY-RELEVANT AND SOCIAL-JUSTICE ORIENTED PERFORMANCE TASKS. THE UNDERLYING THEORETICAL FRAMEWORK FOR ORGANIZING PROSPECTIVE MATHEMATICS TEACHER LEARNING INCORPORATES A FORMATIVE-ASSESSMENT DESIGN TEACHING CYCLE PROCESS ALONG WITH THE RESEARCH-DERIVED PATHWAY TO EQUITABLE MATH INSTRUCTION RESOURCE GUIDE AND TOOLKIT FOR SUPPORTING ALL LEARNERS. THE PROJECT WILL ADVANCE KNOWLEDGE OF HOW TO PREPARE 21ST CENTURY SECONDARY MATHEMATICS TEACHERS WHO POSSESS THE MINDSET, SKILLS, AND KNOWLEDGE TO CREATE AND SUPPORT HIGH-IMPACT MATHEMATICAL LITERACY-DRIVEN INSTRUCTION AND LEARNING IN INCLUSIVE MATHEMATICS CLASSROOMS. FORMATIVE EVALUATION INCLUDING SURVEYS AND INTERVIEWS WILL PROVIDE ONGOING FEEDBACK FOR CONTINUOUS IMPROVEMENT IN THE FOLLOWING AREAS: HOW WELL THE PROJECT ATTRACTS PARTICIPANTS; HOW WELL PROSPECTIVE MATHEMATICS TEACHERS ARE PREPARED FOR THE WORK OF TEACHING IN HIGH NEED SCHOOLS; AND HOW WELL THE PROJECT IS ABLE TO RETAIN BEGINNING TEACHERS IN HIGH-NEED SCHOOLS. THE PROJECT TEAM, ADVISORY BOARD, AND EXTERNAL EVALUATION TEAM WILL GENERATE SUMMATIVE ASSESSMENTS, GAUGE SUCCESS, IDENTIFY CONCERNS, AND PROVIDE RECOMMENDATIONS FOR IMPLEMENTING TIMELY CHANGE. THIS TRACK 1: SCHOLARSHIPS AND STIPENDS PROJECT IS SUPPORTED THROUGH THE ROBERT NOYCE TEACHER SCHOLARSHIP PROGRAM (NOYCE). THE NOYCE PROGRAM SUPPORTS TALENTED STEM UNDERGRADUATE MAJORS TO BECOME EFFECTIVE K-12 STEM TEACHERS AND EXPERIENCED, EXEMPLARY K-12 TEACHERS TO BECOME STEM MENTOR TEACHERS IN HIGH-NEED SCHOOL DISTRICTS. IT ALSO SUPPORTS RESEARCH ON THE RETENTION AND EFFECTIVENESS OF K-12 STEM TEACHERS IN HIGH-NEED SCHOOL DISTRICTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

COMBINED PRIORITY FOR PERSONNEL DEVELOPMENT

THE RONALD E. MCNAIR POST-BACCALAUREATE ACHIEVEMENT PROGRAM

IUCRC PHASE I, SAN JOSE STATE UNIVERSITY: WILDFIRE INTERDISCIPLINARY RESEARCH CENTER (WIRC)

AGENTS OF CHANGE: INVESTIGATING HOW PARTNERSHIPS BETWEEN FACULTY AND LEARNING ASSISTANTS ENABLE PATHWAYS FOR SUSTAINABLE INSTITUTIONAL AND CLASSROOM TRANSFORMATION -THIS PROJECT AIMS TO SERVE THE NATIONAL INTEREST BY EXPLORING HOW PARTNERSHIPS BETWEEN STEM FACULTY AND UNDERGRADUATE LEARNING ASSISTANTS (LAS) CAN ENABLE SUSTAINABLE INSTITUTIONAL AND CLASSROOM TRANSFORMATION THAT LEADS TO MORE INCLUSIVE AND ENGAGING LEARNING ENVIRONMENTS FOR STUDENTS. THE NATIONAL LA MODEL DESCRIBES THE WELL-ESTABLISHED PRACTICE OF EMBEDDING LAS IN COURSES TO ASSIST IN CREATING CULTURALLY RESPONSIVE, STUDENT-CENTERED, ACTIVE LEARNING ENVIRONMENTS. THE MODEL OFFERS SUPPORT TO LAS THROUGH TRAINING THAT CONSISTS OF A COURSE ON TEACHING AND LEARNING AS WELL AS WEEKLY MEETINGS WITH THE COURSE INSTRUCTOR TO REVIEW RELEVANT COURSE CONTENT AND PREPARE FOR CLASS ACTIVITIES. STEM INSTRUCTORS WILL PARTICIPATE IN NOVEL PROFESSIONAL DEVELOPMENT THAT ENGAGES LAS AS PARTNERS IN THE PROCESS OF IMPLEMENTING INCLUSIVE AND ACTIVE LEARNING PRACTICES, LEVERAGING LAS? KNOWLEDGE AS STUDENTS. THESE PARTNERSHIPS WILL ALSO ENABLE MORE ACCESSIBLE RELATIONAL STRUCTURES IN THE CLASSROOM. WHILE PRIOR RESEARCH HAS DEMONSTRATED INCREASED LEARNING GAINS AND OTHER BENEFICIAL OUTCOMES FOR LAS AND STUDENTS, IT IS IMPORTANT TO FULLY CHARACTERIZE WHAT HAPPENS ON THE GROUND THAT LEADS TO SUCH EXCITING LEARNING GAINS, AND TO INSTITUTIONALIZE KEY ASPECTS OF THESE PROGRAMS. IN THIS PROJECT, THE RESEARCHERS PLAN TO STUDY HOW THE NEW SUPPORT STRUCTURES FOR FACULTY OFFERED BY THE PROJECT ENABLE NEW KINDS OF RELATIONSHIPS TO FORM BETWEEN LAS AND FACULTY. THEY WILL THEN MODEL HOW THOSE RELATIONSHIPS LEAD TO SHIFTS IN LA AND FACULTY BELIEFS ABOUT TEACHING AND LEARNING, AND EXAMINE WHICH PROGRAMMATIC ELEMENTS ARE NECESSARY FOR INSTITUTIONAL TRANSFORMATION. LA PROGRAMS NECESSARILY REQUIRE INVOLVEMENT OF MANY STAKEHOLDERS, WHICH MAKES THEM CHALLENGING TO INSTITUTIONALIZE. THEREFORE THE PROJECT INCLUDES THE INFRASTRUCTURE TO COLLABORATE WITH NECESSARY ADMINISTRATORS AND LEARNING CENTERS IN ADDITION TO FACULTY (TENURE- AND NON-TENURE TRACK) AND STUDENTS TO IDENTIFY BARRIERS AND AVENUES TO INSTITUTIONALIZED CHANGE. ONCE COMPLETED, THE CRITICAL ELEMENTS OF THIS PROJECT WILL BE ASSEMBLED TO ASSIST OTHER INSTITUTIONS WHO ARE INTERESTED IN DEVELOPING AN LA MODEL AT THEIR INSTITUTION OR WHO ALREADY HAVE AN LA MODEL AND WOULD LIKE TO FURTHER SUPPORT THEIR LA-FACULTY PARTNERSHIPS. THE THEORY OF CHANGE UNDERPINNING THIS PROJECT BUILDS ON EXISTING MODELS OF LA-FACULTY COLLABORATION AND INSTITUTIONAL CHANGE RESEARCH TO HYPOTHESIZE HOW DEVELOPING STRONG LA-FACULTY PARTNERSHIPS RESULTS IN SUSTAINED IMPROVEMENTS TO STEM INSTRUCTION. THIS PROJECT WILL STUDY WHAT PARTNERSHIP ELEMENTS ARE NECESSARY FOR EFFECTIVE AND EQUITABLE CHANGES IN INSTRUCTION TO OCCUR AND WHAT PROGRAMMATIC STRUCTURE IS REQUIRED TO ENABLE SUCH PARTNERSHIPS. THIS WILL BE CARRIED OUT IN A THREE-PHASE PROGRAM OF RESEARCH, FACULTY PROFESSIONAL DEVELOPMENT, AND INSTITUTIONALIZATION WITH THE FOLLOWING GOALS. FIRST IS TO CHARACTERIZE THE DYNAMICS OF LA-FACULTY PARTNERSHIPS AND HOW THEY IMPACT CLASSROOMS. SECOND IS TO ITERATIVELY DESIGN, IMPLEMENT, AND RESEARCH SUPPORTS FOR LA-FACULTY PARTNERSHIPS INCLUDING CROSS-CAMPUS TRAININGS AND ACADEMIES. THIRD, AND FINALLY, IS TO INSTITUTIONALIZE KEY SUPPORTS FOR SUSTAINING THE LA PROGRAMS. USING A MIXED METHODS APPROACH, INCLUDING ITERATIVE THEMATIC CODING OF QUALITATIVE DATA AND DESCRIPTIVE STATISTICS OF QUANTITATIVE DATA, THIS PROJECT WILL ANALYZE AND TRIANGULATE: I) SURVEYS AND INVENTORIES FOR LAS, FACULTY, AND STUDENTS; II) INTERVIEWS WITH LAS AND FACULTY; III) OBSERVATIONS OF LA-FACULTY PREP MEETINGS; AND IV) ARTIFACTS FROM THE LA PEDAGOGY COURSE AND FACULTY PROFESSIONAL DEVELOPMENT. THIS PROJECT WILL COMPARE LA PROGRAMS ON THREE CALIFORNIA STATE UNIVERSITY CAMPUSES, CAPITALIZING ON EACH OF THEIR STRENGTHS, AND COMPLEMENTING AND EXTENDING EXISTING KNOWLEDGE ON THE POTENTIAL BENEFITS OF LA MODELS. THIS PROJECT WILL COMPARE PROGRESS ACROSS THE THREE INSTITUTIONS AND IDENTIFY CRITICAL FACTORS NECESSARY FOR THE SUCCESS, SCALABILITY, AND SUSTAINABILITY OF LA-FACULTY PARTNERSHIP PROGRAMS, CONTRIBUTING SIGNIFICANTLY TO RESEARCH ON INSTITUTIONAL CHANGE. THE NSF IUSE: EDU PROGRAM SUPPORTS RESEARCH AND DEVELOPMENT PROJECTS TO IMPROVE THE EFFECTIVENESS OF STEM EDUCATION FOR ALL STUDENTS. THROUGH ITS INSTITUTIONAL AND COMMUNITY TRANSFORMATION TRACK, THE PROGRAM SUPPORTS EFFORTS TO TRANSFORM AND IMPROVE STEM EDUCATION ACROSS INSTITUTIONS OF HIGHER EDUCATION AND DISCIPLINARY COMMUNITIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

THE PURPOSE OF OUR PROPOSED RESEARCH IS TO MODEL AND CALIBRATE THE PAH INDICATORS BETWEEN AND WITHIN A VARIETY OF OBJECTS PROBING DIFFERENT TYPES OF ASTROPHYSICAL ENVIRONMENTS. MUCH OF THE RESEARCH WILL RELY ON THE TOOLS AND INNOVATIVE PARADIGMS DEVELOPED AS PART OF THE NASA AMES PAH IR SPECTROSCOPIC DATABASE (PAHDB; HTTP://WWW.ASTROCHEM.ORG/PAHDB/). IN ANTICIPATION OF JWST CONSIDERABLE EFFORT WILL BE PUT INTO EXTENDING AND PREPARING PAHDB TO BE THE GO-TO TOOLKIT FOR ASTRONOMICAL DATA ANALYZES AND INTERPRETATION. THIS WILL BE ACHIEVED BY IMPROVING THE CONTENT TOOLS WEBSITE EMISSION MODELS FITTING ALGORITHMS ETC. THAT MAKE UP PAHDB.

WILDFIRE INTERDISCIPLINARY RESEARCH CENTER: BUILDING WILDFIRE SCIENCES CAPABILITY PURPOSE FOR THE AWARD: TO PROVIDE AN INTEGRATED NATIONAL ASSET THAT WILL SERVE AS AN INFRASTRUCTURE FOR DEVELOPING COMMUNITY OUTREACH, PUBLIC EDUCATION, AND WORKFORCE DEVELOPMENT IN WILDFIRE SCIENCE. ACTIVITIES: - ADD COMPUTING AND DATA STORAGE INFRASTRUCTURE FOR THE NATIONAL WILDFIRE DATA AND COMPUTING HUB - ADD A MULTISPECTRAL INFRARED CAMERA TO THE WILDFIRE REMOTE SENSING FACILITY - ADD AN ADVANCED THERMAL IMAGING SYSTEM AND A STATE-OF-THE-ART DATA ACQUISITION SETUP TO THE WILDFIRE DYNAMICS LABORATORY - SUPPORT NECESSARY TRAVEL, TRAINING, AND COMMUNICATION EQUIPMENT COSTS FOR THE COMMUNITY WILDFIRE RESILIENCE LABORATORY DELIVERABLE AND EXPECTED OUTCOMES: PROVIDE FACULTY WITHIN WIRC STATE-OF-THE-ART INFRASTRUCTURE AND PLACE SAN JOS STATE UNIVERSITY AND SILICON VALLEY AT THE FOREFRONT OF WILDFIRE RESEARCH INTENDED BENEFICIARY: FACULTY WITHIN THE WILDFIRE INTERDISCIPLINARY RESEARCH CENTER

TRANSFER ADVOCACY GROUPS: TRANSFORMING CULTURE TO SUPPORT TRANSFER STUDENTS OF COLOR IN UNDERGRADUATE PHYSICS -OVER THE PAST DECADE NEARLY HALF OF ALL POST-SECONDARY STUDENTS OF COLOR HAVE ATTENDED COMMUNITY COLLEGES. THIS PROJECT IS A COLLABORATION OF TWO INSTITUTIONS, SAN JOSE STATE UNIVERSITY AND MICHIGAN STATE UNIVERSITY. THE PROJECT AIMS TO ADDRESS THE URGENT NEED TO SUPPORT COMMUNITY COLLEGE TRANSFER STUDENTS OF COLOR IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) FIELDS BY TRANSFORMING THE RECEIVING BACCALAUREATE GRANTING INSTITUTIONS. CHANGING THIS RACIALIZED TRANSFER FUNCTION REQUIRES UNDERSTANDING AND TRANSFORMING THE INSTITUTIONAL CULTURE AROUND TRANSFER IN STEM AT BOTH THE SENDING AND RECEIVING INSTITUTIONS. BY PARTNERING WITH TRANSFER STUDENTS OF COLOR AS DESIGN PARTNERS, THE GOAL OF THIS PROJECT IS TO CRAFT SUPPORT FOR NEW-TO-CAMPUS TRANSFER STUDENTS OF COLOR IN STEM BY ENGAGING IN UNIVERSITY INSTITUTIONAL CHANGE EFFORTS. THIS PROJECT WILL CREATE TRANSFER ADVOCACY GROUPS (TAGS) WHICH ARE COLLABORATIONS OF FACULTY, STUDENTS, AND ADVISORS WORKING TO IMPLEMENT INTERVENTIONS TO SUPPORT TRANSFER STUDENTS OF COLOR IN STEM AND PROMOTE A TRANSFER RECEPTIVE CULTURE. THE PROJECT FOCUSES ON TRANSFER STUDENTS OF COLOR MAJORING IN PHYSICS AS WELL AS STUDENTS OF COLOR TAKING INTRODUCTORY PHYSICS CLASSES AT BOTH INSTITUTIONS. THE SCOPE OF THE PROJECT INCLUDES DOCUMENTING THE EXPERIENCES OF TRANSFER STUDENTS OF COLOR, A POPULATION THAT IS LARGELY ABSENT FROM THE LITERATURE ON RACIALIZED EXPERIENCES IN UNDERGRADUATE STEM. THE DATA COLLECTED WILL ALLOW THE LIVED EXPERIENCE AND PERSPECTIVES OF TRANSFER STUDENTS OF COLOR TO BE CENTERED IN THE WORK OF THE TAGS AND PROVIDES AN UNDERSTANDING OF THE EXTENT TO WHICH INSTITUTIONAL CHANGE ADDRESSES THEIR NEEDS AND REALITIES. ANALYSES OF RESEARCH CONDUCTED IN COLLABORATION WITH TRANSFER STUDENTS OF COLOR AS WELL AS RESEARCH WITH RESPECT TO INSTITUTIONAL POLICIES AND PRACTICES WILL INFORM THE WORK OF THE TAGS AT EACH INSTITUTION. TAGS WILL COLLABORATE WITH KEY STAKEHOLDERS TO IMPLEMENT CHANGES IN THE UNIVERSITIES. THROUGH THESE ACTIVITIES, THE PROJECT AIMS TO TRANSFORM CULTURE AT BOTH DEPARTMENTAL AND COLLEGE LEVELS SO IT IS MORE TRANSFER-RECEPTIVE AND SUPPORTIVE OTHERS PARTNERING WITH TRANSFER STUDENTS OF COLOR ON INSTITUTIONAL CHANGE EFFORTS. THIS COLLABORATIVE PROJECT IS FUNDED THROUGH THE RACIAL EQUITY IN STEM EDUCATION PROGRAM (EDU RACIAL EQUITY). THE PROGRAM SUPPORTS RESEARCH AND PRACTICE PROJECTS THAT INVESTIGATE HOW CONSIDERATIONS OF RACIAL EQUITY FACTOR INTO THE IMPROVEMENT OF SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) EDUCATION AND WORKFORCE. AWARDED PROJECTS SEEK TO CENTER THE VOICES, KNOWLEDGE, AND EXPERIENCES OF THE INDIVIDUALS, COMMUNITIES, AND INSTITUTIONS MOST IMPACTED BY SYSTEMIC INEQUITIES WITHIN THE STEM ENTERPRISE. THIS PROGRAM ALIGNS WITH NSF?S CORE VALUE OF SUPPORTING OUTSTANDING RESEARCHERS AND INNOVATIVE THINKERS FROM ACROSS THE NATION'S DIVERSITY OF DEMOGRAPHIC GROUPS, REGIONS, AND TYPES OF ORGANIZATIONS. PROGRAMS ACROSS EDU CONTRIBUTE FUNDS TO THE RACIAL EQUITY PROGRAM IN RECOGNITION OF THE ALIGNMENT OF ITS PROJECTS WITH THE COLLECTIVE RESEARCH AND DEVELOPMENT THRUSTS OF THE FOUR DIVISIONS OF THE DIRECTORATE. THIS COLLABORATIVE PROJECT IS CO-FUNDED THROUGH THE DIVISION OF PHYSICS. THE DIVISION OF PHYSICS (PHY) SUPPORTS PHYSICS RESEARCH AND THE PREPARATION OF FUTURE SCIENTISTS IN THE NATION?S COLLEGES AND UNIVERSITIES ACROSS A BROAD RANGE OF PHYSICS DISCIPLINES THAT SPAN SCALES OF SPACE AND TIME FROM THE LARGEST TO THE SMALLEST AND THE OLDEST TO THE YOUNGEST. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

A COMPREHENSIVE TESTING PLATFORM FOR MECHANICAL HEART VALVES TO PROPEL INNOVATION TOWARDS ANTICOAGULANT-INDEPENDENCE

MBRS SCORE PROGRAM AT SAN JOSE STATE UNIVERSITY

MATERIAL CHARACTERIZATION AND METROLOGY PHASE III

THE YOUTH DIGITAL STORYTELLING STEM ACADEMY

WORK WITH NASA AND THE REST OF THE THERMO-PHYSICS FACILITIES BRANCH PROJECT TEAM TO DEVELOP JOB AIDS FOR TSF FACILITY OPERATIONS WITH LEAD RESPONSIBILITY FOR THE COMPONENTS BASED ON THE MACROERGONOMICS AND HUMAN PERFORMANCE TECHNOLOGY. 2. IN COLLABORATION WITH THE OTHER MEMBERS OF THE TEAM DEVELOP AND TEST JOB AIDS AND DOCUMENT OPERATIONAL PROCESSES FOR TSF FACILITY OPERATIONS. 3. IMPLEMENT MACROERGONOMICS AND HUMAN PERFORMANCE TECHNOLOGY APPROACH TO DEVELOP AND TEST JOB AIDS THAT ARE COMPARABLE TO TSF FACILITY OPERATIONS. 4. VALIDATION OF THE PROPOSED JOB AIDS. 5. EVALUATE AND ANALYZE RESEARCH PROCESSES INCLUDING DEVELOPING PROCESS MAPS DEPICTING INPUTS AND OUTPUTS OF SPECIFIC FACILITY OPERATION TASKS. 6. VALIDATION OF THE PROPOSED PROCESS MAPS. 7. REVIEW JOB AIDS AND RESEARCH PROCESS MAPS TO DETERMINE IMPLEMENTATION OF WORK PRACTICES TO INCREASE EFFICACY EFFICIENCY AND SAFETY. 8. DEVELOPMENT AND DELIVERY OF A HIGHER-LEVEL ORGANIZATIONAL ANALYSIS. 9. DELIVERY OF A COMPLETED LIVING HANDBOOK FOR CODE TSF THAT ALLOWS FOR ADAPTING AND CHANGING NEEDS OF THE DIVISION AND ITS PROCESSES GOALS AND MISSION.

CHILD CARE ACCESS MEANS PARENTS IN SCHOOL (CCAMPIS)

NEIGHBORHOOD CRIME SURVEY: AN EXAMINATION OF THE RELATIONSHIP BETWEEN IMMIGRATION AND VICTIMIZATION

SPECIAL EDUCATION-PERSONNEL PREPARATION TO IMPROVE SERVICES AND RESULTS FOR CHILDREN WITH DISABILITIES - COMBINED PRIORITY FOR PERSONNEL PREPARATION

A TRANSFORMATIVE MASTER'S PROGRAM IN HIGH ENERGY PHYSICS

SCC-CIVIC-FA TRACK B: PARTICIPATORY ACTION RESEARCH TO ENHANCE EQUITY AND PREVENT MORAL INJURY IN COMMUNITY PARAMEDICINE -COMMUNITY PARAMEDICINE (CP) HAS EMERGED AS A VITAL COMPONENT OF EMERGENCY MEDICAL SERVICES, PROVIDING NON-POLICE RESPONSES TO MENTAL HEALTH CRISES. COMMUNITY PARAMEDICS ARE EXPOSED TO CHALLENGING CIRCUMSTANCES, WHICH MAY LEAD TO MORAL DISTRESS AND INJURY. THIS SCOPE OF WORK REQUIRES EQUITY-ORIENTED PRACTICES TO IMPROVE THE DELIVERY OF CRITICAL SERVICES TO VULNERABLE COMMUNITY MEMBERS EXPERIENCING HOMELESSNESS, MENTAL HEALTH CRISES, AND ADDICTION. THIS PROJECT USES A PARTICIPATORY ACTION RESEARCH APPROACH TO PREVENT MORAL INJURY AMONG CP FIRST RESPONDERS AND IMPROVE THEIR EQUITY-BASED UNDERSTANDING AND PRACTICES IN WORKING WITH VULNERABLE POPULATIONS. THIS COLLABORATIVE EFFORT LED BY CIVIC PARTNER SAN FRANCISCO FIRE DEPARTMENT, RESEARCH PARTNERS FROM SAN JOS? STATE UNIVERSITY AND THE VETERANS HEALTH ADMINISTRATION, AND WITH COLLABORATION FROM RICHMOND AREA MULTI-SERVICES INC., SEEKS TO ENHANCE THE WELL-BEING OF CP FIRST RESPONDERS WHILE IMPROVING THE EQUITABLE DELIVERY OF CRITICAL SERVICES TO VULNERABLE COMMUNITY MEMBERS. THE PROJECT?S OVERARCHING GOAL IS TO STRENGTHEN CP WORK TO IMPROVE THE WELLBEING OF RESIDENTS OF SAN FRANCISCO, ULTIMATELY CREATING SUSTAINABLE OUTCOMES SCALABLE ACROSS THE U.S. THIS STUDY AIMS TO ADDRESS TWO INTERRELATED GAPS IN RESEARCH AND INNOVATION: MORAL INJURY AND EQUITY. WHILE EACH IS INDEPENDENTLY IMPORTANT, WE THEORIZE THAT THEY OPERATE IN A SELF-AMPLIFYING FEEDBACK LOOP, WHEREBY WITNESSING INEQUITIES CAUSES MORAL DISTRESS AND SETS THE STAGE FOR MORAL INJURY. IN TURN, CP MEMBERS WHO ARE EMOTIONALLY NUMB AND DISENGAGED AS A RESULT OF MORAL INJURY AND BURNOUT ARE MORE LIKELY TO ENGAGE IN PRACTICES THAT, WHILE LIKELY UNINTENTIONAL, REINFORCE INEQUITIES BY CAUSING HARM TO CLIENTS, RATHER THAN INTERVENING TO REDUCE DISPARITIES. ALTHOUGH EXTENSIVE RESEARCH EXISTS ON THE EVALUATION AND TREATMENT OF MORAL INJURY IN MILITARY VETERANS AND MORAL DISTRESS AMONG NURSES, THERE HAS BEEN NO PRIOR RESEARCH EVALUATING, PREVENTING OR TREATING MORAL DISTRESS OR INJURY AMONG EMERGENCY MEDICAL TECHNICIANS (EMTS) OR PARAMEDICS. THERE IS ALSO NO PRIOR RESEARCH EXAMINING THE EFFECTIVENESS OF TRAINING FOR EMTS OR PARAMEDICS ON EQUITY. THIS INTERVENTION STUDY FILLS A CRITICAL GAP BY EVALUATING MORAL DISTRESS AND INJURY USING VALIDATED SCALES AND IDENTIFYING INDICATORS OF WORKPLACE FUNCTIONING FOR FIRST RESPONDERS THAT ARE MEANINGFUL TO CLIENTS AND AGENCIES. THE TARGETED INTERVENTIONS INCLUDE EQUITY AND ETHICS CONVERSATIONS, INDIVIDUAL SKILLS TRAINING, AND PUBLIC EDUCATION CAMPAIGNS TO CREATE A SUPPORTIVE AND TRAUMA-INFORMED ENVIRONMENT WITHIN THE SFFD CP DIVISION AND STRENGTHEN EQUITY CAPACITY. WE WILL PILOT A NOVEL DATA INTEGRATION STRATEGY TO IMPROVE COMPLETENESS AND ACCURACY OF CP DATA TO EVALUATE DISPARITIES IN CP KEY PERFORMANCE INDICATORS. THE CIVIC INNOVATION CHALLENGE IS A COLLABORATION WITH DEPARTMENT OF ENERGY, DEPARTMENT OF HOMELAND SECURITY, AND THE NATIONAL SCIENCE FOUNDATION THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

THE PROPOSED PROJECT WILL DEMONSTRATE THE EFFECTIVENESS OF FARM RUNOFF TREATMENT SYSTEMS IN REDUCING NUTRIENT DISCHARGES TO COASTAL WATERWAYS AND PROVIDE A BLUEPRINT FOR SCALING-UP TREATMENT SYSTEMS WITHIN TWO KEY AGRICULTURAL WATERSHEDS OF THE MONTEREY BAY, CA. IN ADDITION, THIS PROJECT WILL EXAMINE THE POTENTIAL LINK BETWEEN AGRICULTURAL NUTRIENT DISCHARGES AND THE GROWTH OF HARMFUL ALGAL BLOOMS (HABS).

THREE YEAR'S UNIVERSITY PARTNERSHIP

SPECIAL EDUCATION-PERSONNEL PREPARATION TO IMPROVE SERVICES AND RESULTS FOR CHILDREN WITH DISABILITIES - COMBINED PRIORITY FOR PERSONNEL PREPARATION

THIS COOPRATIVE AGREEMENT WILL SUPPORT THREE YEARS PARTNERSHIP BETWEEN SAN JOSE UNIVERSITY AND ALLAMA IQBAL OPEN UNIVERSITY.

COMBINED PRIORITY FOR PERSONNEL DEVELOPMENT

RONALD E. MCNAIR POST-BACCALAUREATE ACHIEVEMENT

SHIP OPERATIONS

COLLABORATIVE RESEARCH: THERMODYNAMIC AND DYNAMIC DRIVERS OF THE ARCTIC SEA ICE MASS BUDGET AT MOSAIC

CAREER: FORAGING ECOLOGY AND PHYSIOLOGY OF EMPEROR PENGUINS IN THE ROSS SEA

MRI: ACQUISITION OF HYBRID CPU/GPU HIGH PERFORMANCE COMPUTING AND STORAGE FOR STEM RESEARCH AND EDUCATION AT SAN JOSE STATE UNIVERSITY

CAREER: TOWARDS A BETTER UNDERSTANDING OF WILDFIRE-ATMOSPHERE INTERACTIONS-INTEGRATING FIRE WEATHER RESEARCH AND EDUCATION

U-RISE PROGRAM AT SAN JOSE STATE UNIVERSITY - SJSU U-RISE PROGRAM ABSTRACT THE SJSU U-RISE PROGRAM IS COMMITTED TO ITS MISSION TO SUPPORT THE TRAINING OF UNDERREPRESENTED STUDENTS TO SUCCEED IN PHD OR MD/PHD PROGRAMS IN THE BIOMEDICAL SCIENCES, JUST LIKE OUR PREVIOUS COMMITMENT TO NIGMS TRAINING PROGRAMS FOR THE PAST 33 YEARS. THE ADMINISTRATIVE STAFF OF OUR U- RISE IS MADE OF ONE PI WHO IS A FORMER MARC DIRECTOR, ONE CO-PI (A CURRENT RISE PROGRAM COORDINATOR), AND A STUDENT COORDINATOR; ALL THREE FROM MINORITY BACKGROUNDS. IN ADDITION, WE HAVE A HIGHLY MOTIVATED GROUP OF RESEARCH MENTORS AND A COMMITTED INSTITUTIONAL ADMINISTRATIVE STAFF WHO ENDORSE THE MISSION OF THIS PRESTIGIOUS NIGMS PROGRAM IN ITS ENTIRETY. SJSU IS A PUBLIC, PUI HISPANIC SERVING INSTITUTION, WITH A LARGE POOL OF UNDERREPRESENTED STUDENTS (26%) IN THE U-RISE SERVING DEPARTMENTS, WHICH CAN GREATLY BENEFIT FROM THE OPPORTUNITIES FACILITATED BY THIS PROGRAM. RECRUITMENT WILL RELY ON THE AMPLE SCHOOL DATABASE WITH POTENTIAL URM APPLICANTS, ANNOUNCEMENTS VIA WEBSITE AND CLASS VISITATIONS, AND RECOMMENDATIONS FROM OUR DILIGENT RESEARCH FACULTY. OUR SPECIFIC AND MEASURABLE AIMS INCORPORATE TRAINING OF MENTORS TO EMPHASIZE A STUDENT-CENTERED APPROACH THAT LEADS U-RISE TRAINEES TO BECOME INDEPENDENT CRITICAL THINKERS ENGAGED IN MEANINGFUL RESEARCH PROJECTS. TRAINEES WILL BE PAIRED WITH ONE MENTOR WHOSE RESEARCH ALIGNS WITH THAT OF THE TRAINEE. TO LAUNCH TRAINEES INTO A SUCCESSFUL FIRST-YEAR RESEARCH EXPERIENCE, WE WILL OFFER WORKSHOP ACTIVITIES THAT RELY ON RIGOR AND REPRODUCIBLE APPROACHES THAT COMBINE HANDS-ON LABORATORY TECHNIQUES AND CRITICAL THINKING SKILLS, FOLLOWED BY A RESEARCH EXPERIENCE IN THE PI’S LAB. BY THE SECOND YEAR, TRAINEES WILL GO AWAY FOR A SUMMER RESEARCH EXPERIENCE AT A RESEARCH- INTENSIVE INSTITUTION. REQUIRED COMPONENTS OF THE PROGRAM INCLUDE INDEPENDENT AND MEANINGFUL RESEARCH EXPERIENCE THROUGHOUT THE 2 YEARS IN THE PROGRAM, PARTICIPATION IN A WEEKLY SEMINAR DURING THE ACADEMIC YEAR TO LEARN ABOUT PROFESSIONAL SKILLS, WORK ON ALL THE DOCUMENTS FOR APPLICATIONS TO SUMMER PROGRAMS (FIRST YEAR) AND PHD OR MD/PHD APPLICATIONS (2ND YEAR) AS WELL AS PRESENTATION SKILLS IN PREPARATION TO PRESENT AT ONE OF THE NATIONAL CONFERENCES (E.G., SACNAS, ABRCMS). ADDITIONAL MENTORING WILL BE PROVIDED BY GRADUATES FROM OUR FORMER TRAINING PROGRAMS WHO ARE NOW IN GRADUATE SCHOOL OR ARE PROFESSIONALS IN A RANGE OF JOBS (ACADEMIC, INDUSTRY, GOVERNMENT) IN THE BIOMEDICAL SCIENCES AND FROM POSTDOCTORAL FELLOWS FROM STANFORD UNIVERSITY. OUTCOMES WILL BE DISSEMINATED THROUGH VARIOUS MEANS, INCLUDING PUBLIC WEBSITES, POSTERS IN THE SCIENCE BUILDING, RECORDINGS OF TRAINEES’ TESTIMONIES, CLASSROOMS VISITATIONS, DURING FRESHMAN ORIENTATION, AND STEM EVENTS SUCH AS OUR STUDENT RESEARCH DAY.

RU(II)-DIIMINE LABELED P450 MUTANTS FOR THE SELECTIVE HYDROXYLATION OF SUBSTRATE

AIRBORNE INSTRUMENTS TO QUANTIFY OPTICAL TURBULENCE, AEROSOL, AND SURFACE WAVE IMPACT ON OPTICAL PROPAGATION IN THE MARINE ATMOSPHERIC BOUNDARY LAYERS

CHIROPTICAL INDUCED CPL-BASED TOOL AS A PROBE OF BIOLOGICAL SUBSTRATES

BLOCKING CATIONIC ANTIMICROBIAL PEPTIDE-RESISTANCE IN PSEUDOMONAS AERUGINOSA

CALIFORNIA COMMUNITY AND EARTH-SYSTEM INTEGRATED CLIMATE RESILIENCE CENTER {CALCEI CRC}

NEXTGEN AIRSPACE PROJECTTHE NEXTGEN AIRSPACE PROJECT WILL DEVELOP AND EXPLORE FUNDAMENTAL CONCEPTS AND INTEGRATED SOLUTIONS THAT ADDRESS THE OPTIMAL

LIBRARIANS FOR THE 21ST CENTURY

MOLECULAR MECHANISMS OF NEURAL CIRCUIT FORMATION

CHILD CARE

MRI: TRACK 1 ACQUISITION OF A 500 MHZ NMR SPECTROMETER TO ENHANCE RESEARCH AND STUDENT TRAINING CAPABILITIES AT SAN JOSE STATE UNIVERSITY AND NEIGHBORING INSTITUTIONS -THIS AWARD IS JOINTLY SUPPORTED BY THE MAJOR RESEARCH INSTRUMENTATION (MRI) AND CHEMISTRY RESEARCH INSTRUMENTATION PROGRAMS. SAN JOS? STATE UNIVERSITY (SJSU) IS ACQUIRING A 500 MHZ NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROMETER WITH A 2-CHANNEL BROADBAND PROBE TO SUPPORT THE RESEARCH OF PROFESSOR MADALYN R. RADLAUER, ALONG WITH COLLEAGUES NINGKUN WANG, PHILIP T. DIRLAM, GILLES MULLER, AND LAURA C. MILLER CONRAD. THIS INSTRUMENT GREATLY EXPANDS AND MODERNIZES NMR CAPABILITIES BOLSTERING RESEARCH AND TRAINING EFFORTS AND ENABLES CURRICULAR ENHANCEMENT IN SCIENCE AND ENGINEERING. THE INSTRUMENT IS THE FIRST NMR HOUSED IN THE DEDICATED NMR FACILITY IN THE NEW INTERDISCIPLINARY SCIENCE BUILDING AT SJSU. NUMEROUS RESEARCH PROGRAMS FROM THE SJSU, AND NEIGHBORING SANTA CLARA UNIVERSITY (SCU) ACTIVE IN BOTH RESEARCH AND TEACHING ARE ENABLED BY THE INSTRUMENT ADDITIONALLY, RESEARCH SCIENTISTS AT NASA AMES RESEARCH CENTER, LOCAL COMMUNITY COLLEGES (FOOTHILL COLLEGE AND DE ANZA COLLEGE), AND A TEACHER FROM LOS ALTOS HIGH SCHOOL USE THE NMR FOR RESEARCH PURPOSES AND TO COLLECT DATA FOR COURSES AT THEIR SCHOOLS. THIS INSTRUMENT ESPECIALLY IMPACTS UNDERGRADUATE TRAINING THROUGH BOTH RESEARCH AND COURSEWORK. ALSO, AS SJSU SERVES A DIVERSE STUDENT BODY, A MAJORITY OF THE IMPACTED STUDENTS ARE FROM GROUPS THAT ARE TRADITIONALLY UNDERREPRESENTED IN STEM. THE ACQUIRED 500 MHZ NMR INSTRUMENT SUPPORTS RESEARCH IN A RANGE OF DISCIPLINES. IT PROVIDES HIGH RESOLUTION SPECTRA, OBSERVATION OF A WIDE RANGE OF NUCLEI, VARIABLE TEMPERATURE CAPABILITIES, AND SIGNIFICANTLY IMPROVED AUTOMATION, ENABLING NEW RESEARCH DIRECTIONS AT SJSU. THIS INSTRUMENT ENABLES THE DEVELOPMENT AND EXAMINATION OF (1) ORGANOMETALLIC CATALYSTS WITHIN POLYMER SCAFFOLDS; (2) POLYMER-SUPPORTED HYPERVALENT IODINE REAGENTS; (3) SMALL MOLECULE ANTIBACTERIAL AGENTS; (4) LN(III) COMPLEXES AS CHIRAL STRUCTURAL PROBES; (5) PROTEIN CONFORMATIONAL DYNAMICS; (6) STABLE FREE RADICALS; (7) UBIQUITIN CONJUGATED PROTEINS; (8) ARTIFICIAL INTELLIGENCE TO PROBE TIME DOMAIN NMR SIGNALS; (9) NOVEL PLANT NATURAL PRODUCTS FROM CALIFORNIA NATIVE PLANTS; (10) PROTOMETABOLIC SYSTEMS CHEMISTRY; (11) CLIMATE IMPACTS OF ORGANIC CHEMISTRY IN ATMOSPHERIC AEROSOLS AND CLOUDS; (12) MULTIDIMENSIONAL COHERENT SPECTROSCOPY ACROSS THE ELECTROMAGNETIC SPECTRUM; (13) MICROBIAL METABOLITES AND CELL COMPOSITION; (14) ORGANOMETALLIC COMPLEXES, PEPTIDOMIMETICS, AND NANOMATERIALS AT SCU; AND (15) STUDIES WITHIN THE SPACE SCIENCE DIVISION AT AMES. IN ADDITION, STUDENTS BENEFIT FROM EITHER HANDS-ON TRAINING OR DATA COLLECTED FROM THIS INSTRUMENT FOR THEIR COURSEWORK ANNUALLY. IN RESPONSE TO GLOBAL HELIUM SUPPLY CHALLENGES, THE ACQUISITION OF THIS INSTRUMENT INCLUDES A SUPERCONDUCTING MAGNET WITH A LOW LOSS CRYOSTAT REDUCING THE INSTITUTION?S CONSUMPTION OF HELIUM. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

MRI: ACQUISITION OF INSTRUMENTATION FOR PROTEOMICS RESEARCH OR TRAINING ENCOMPASSING INVESTIGATORS' NEEDS LAB AT SJSU (PROTEIN LAB)

COMBINED PRIORITY FOR PERSONNEL PREPARATION

ENVIRONMENTAL UNCULTIVABLE BACTERIA MODEL FOR UNDERSTANDING HUMAN PERIODONTITIS

MRI: ACQUISITION OF AN HPLC COUPLED MASS SPECTROMETER FOR PROTEOMICS, METABOLOMICS, AND SMALL MOLECULE APPLICATIONS TO EXPAND AND UPGRADE THE SJSU PROTEIN LAB

NEW START GRANT - ENHANCING RESEARCH AND EDUCATION IN HIGH RESOLUTION ACTIVE REMOTE SENSING TECHNOLOGY AND LANDSCAPE MODELING

ENFRANCHISED: FOSTERING CIVIC EMPOWERMENT IN A DIGITAL WORLD

VECTOR CONTROL STRATEGY THROUGH INHIBITION OF AEDES AEGYPTI MIDGUT PROTEASES

PROJECT MOSAIC

COLLABORATIVE RESEARCH: NRT-QL: A PROGRAM FOR TRAINING A QUANTUM WORKFORCE

EFFECTS OF THE RATE OF ENVIRONMENTAL CHANGE ON MUTATIONAL PATTERNS AND EVOLUTIONARY CONSTRAINTS - PROJECT SUMMARY POPULATIONS MUST BE ABLE TO ADAPT IN ENVIRONMENTAL CONDITIONS THAT MAY CHANGE EITHER SUDDENLY (WITHIN ONE GENERATION) OR GRADUALLY (OVER MULTIPLE GENERATIONS). THEORETICAL MODELS PREDICT THAT THESE DIFFERENCES IN THE RATE OF ENVIRONMENTAL CHANGE WILL FUNDAMENTALLY INFLUENCE THE NUMBER AND EFFECT SIZES OF MUTATIONS THAT FIX, BUT FEW STUDIES HAVE MECHANISTICALLY EXAMINED THE GENETICS OF ADAPTATION IN ENVIRONMENTS THAT BECOME MORE STRESSFUL OVER TIME. MOREOVER, THE THEORETICAL MODELS DO NOT ALWAYS ACCOUNT FOR WELL-KNOWN PHENOMENA THAT INTRODUCE EVOLUTIONARY CONSTRAINTS, SUCH AS GENOTYPE BY ENVIRONMENT (GXE) INTERACTIONS AND PLEIOTROPY. THE GOAL OF THIS RESEARCH IS TO COMPARE PATTERNS OF GENOME EVOLUTION AND EFFECTS OF MUTATIONS IN RNA VIRUSES UNDER SUDDEN OR GRADUAL ENVIRONMENTAL CHANGE, AND TO USE THESE DATA TO EVALUATE THEORETICAL MODELS OF ADAPTATION IN ENVIRONMENTS THAT CHANGE AT DIFFERENT RATES. THE PROJECT USES TEMPERATURE-RESISTANT POPULATIONS OF THE MODEL BACTERIOPHAGE 6 CYSTOVIRUS THAT WERE PREVIOUSLY GENERATED THROUGH AN EVOLUTION EXPERIMENT IN WHICH VIRAL POPULATIONS WERE EXPOSED TO A HEAT SHOCK TEMPERATURE THAT WAS INCREASED EITHER GRADUALLY (GRADUAL POPULATIONS) OR SUDDENLY (SUDDEN POPULATIONS). HERE, WE PROPOSE TO USE THESE POPULATIONS TO EXAMINE PATTERNS OF MUTATION FIXATION AND TO CHARACTERIZE THE ROLE OF GXE INTERACTIONS AND PLEIOTROPY IN ENVIRONMENTS THAT CHANGE AT DIFFERENT RATES. SPECIFICALLY, WE WILL 1) EVALUATE THE NUMBER OF MUTATIONS, THEIR TIMES TO FIXATION, AND HAPLOTYPE DIVERSITY OF SUDDEN AND GRADUAL POPULATIONS; AND 2) MEASURE THE EFFECTS OF SEQUENTIAL MUTATIONS FROM SELECT LINEAGES ON BOTH VIRAL THERMOSTABILITY AND GROWTH RATE, AND CORRELATE THOSE EFFECTS WITH THE RATE OF ENVIRONMENTAL CHANGE EXPERIENCED BY THE LINEAGE. OUR STUDY WILL ADDRESS THE CENTRAL QUESTION IN EVOLUTIONARY BIOLOGY OF HOW CHANGES TO THE STRENGTH AND TEMPO OF SELECTION INFLUENCE ADAPTATION, AND WILL ILLUMINATE THE MECHANISTIC UNDERPINNINGS OF ADAPTATION IN DIFFERENT RATES OF ENVIRONMENTAL CHANGE. ESTABLISHING THE SELECTIVE PRESSURES AND CONSTRAINTS AT PLAY IN CHANGING ENVIRONMENTS WILL GIVE US TOOLS TO PREDICT OR CONTROL VIRAL EVOLUTION.

NEUROHUMORAL INTERACTIONS COORDINATING MAMMALIAN CARDIOMYOCYTE SIZE AND PROLIFERATION - PROJECT SUMMARY HEART FAILURE AFTER ISCHEMIC INJURY REMAINS A LEADING CAUSE OF DEATH IN THE UNITED STATES DUE TO THE INABILITY OF ADULT HUMANS TO REPLACE LOST CARDIAC MUSCLE AFTER HEART ATTACK. IN CONTRAST, NEWBORN MAMMALS POSSESS A TRANSIENT BUT ROBUST CAPACITY FOR COMPLETE FUNCTIONAL HEART REGENERATION. CARDIAC REGENERATION IN NEONATAL RODENTS RELIES ON THE PROLIFERATION OF PRE-EXISTING CARDIOMYOCYTES (CM), HIGHLIGHTING THE IMPORTANCE OF UNDERSTANDING CM CELL CYCLE REGULATION. THIS REGENERATIVE CAPACITY IS LOST SHORTLY AFTER BIRTH WHEN THE MAJORITY OF CMS UNDERGO CELL CYCLE ARREST, POLYPLOIDIZATION, AND HYPERTROPHIC GROWTH. THE LONG-TERM GOAL OF MY PROPOSED RESEARCH IS TO DEFINE THE PHYSIOLOGICAL TRIGGERS THAT MEDIATE THE POSTNATAL LOSS OF MAMMALIAN HEART REGENERATIVE POTENTIAL. IN THIS PROPOSAL, WE BUILD UPON OUR RECENT DISCOVERY DEMONSTRATING THAT COMBINED INHIBITION OF THYROID HORMONE (TH) AND ADRENERGIC RECEPTOR (AR) SIGNALING DURING POSTNATAL DEVELOPMENT INCREASES CM PROLIFERATION, DELAYS POLYPLOIDIZATION, AND PROMOTES HEART FUNCTIONAL REGENERATION IN OLDER JUVENILE MICE. DESPITE THE SIGNIFICANCE OF THESE FINDINGS, THE CELLULAR AND MOLECULAR MECHANISMS DOWNSTREAM OF THESE PATHWAYS IMPACTING CM CELL DIVISION REMAIN UNCLEAR. WHILE TH AND AR SIGNALING ARE KNOWN TO PROMOTE CM HYPERTROPHIC GROWTH, THE INTERRELATIONSHIP BETWEEN CM SIZE AND CELL CYCLE CONTROL IS NOT WELL UNDERSTOOD. OUR CENTRAL HYPOTHESIS IS THAT TH AND AR SIGNALING INTERACTIONS AFTER BIRTH DRIVE CM HYPERTROPHIC GROWTH AND LIMITS PROLIFERATIVE POTENTIAL. WE ARE PIONEERING THE APPLICATION OF DIGITAL HOLOGRAPHIC MICROSCOPY TO VISUALIZE THREE-DIMENSIONAL CHANGES IN CM VOLUME IN RESPONSE TO HORMONAL STIMULATION IN REAL-TIME WITH SINGLE CELL RESOLUTION. WE ARE USING THIS TECHNOLOGY TO RESOLVE IF CM HYPERTROPHIC GROWTH INHIBITS CELL CYCLE PROGRESSION AND DIVISION. WE WILL TEST OUR HYPOTHESIS IN THE FOLLOWING SPECIFIC AIMS: AIM 1: DETERMINE HOW TH AND AR SIGNALING INTERACTIONS PROMOTE CM HYPERTROPHY. AIM 2: DEFINE HOW TH AND AR SIGNALING INTERACTIONS INHIBIT CM PROLIFERATION. AIM 3: IDENTIFY THE MOLECULAR TARGETS DOWNSTREAM OF TH AND AR SIGNALING REGULATING CM HYPERTROPHY AND PROLIFERATION. THE RESULTS OF THESE STUDIES ARE EXPECTED TO REVEAL NEW INSIGHTS INTO THE CELLULAR AND MOLECULAR MECHANISMS FACILITATING THE LOSS OF HEART REGENERATIVE CAPACITY IN MAMMALS, WHICH MAY HELP INFORM NOVEL TREATMENT STRATEGIES TO IMPROVE HEART REGENERATIVE CAPACITY IN ADULT HUMANS. THIS SURE-FIRST AWARD WILL FUND THE RESEARCH OF APPROXIMATELY 40 UNDERGRADUATES AND 8 M.S STUDENTS OVER THE COURSE OF FOUR YEARS, INCLUDING MANY MINORITY TRAINEES AT SAN JOSE STATE UNIVERSITY, A PRIMARILY UNDERGRADUATE AND MASTER’S-LEVEL INSTITUTION COMMITTED TO TRAINING UNDER-REPRESENTED MINORITY STUDENTS. UNDERGRADUATES WILL PERFORM THE MAJORITY OF THE PROPOSED WORK, WITH TRAINING AND MENTORSHIP FROM SENIOR GRADUATE STUDENTS AND THE PI. THIS FUNDING WOULD ALLOW THE PI TO CONTINUE TO DEVELOP A STRONG TRACK RECORD IN RESEARCH, GIVE MEANINGFUL SCIENTIFIC EXPERIENCES TO UNDERGRADUATE STUDENTS, AND STRENGTHEN THE RESEARCH ENVIRONMENT AT SAN JOSE STATE UNIVERSITY.

TALENT SEARCH PROGRAM

CHILDCARE ACCESS MEANS PARENTS IN SCHOOL - CHILD CARE

SATELLITE-DERIVED PM2.5 GRIDS WITH DISPERSION MODEL DOWNSCALING: PM2.5 DATA TO SUPPORT COMMUNITY-SCALE AIR QUALITY HEALTH RESEARCH AND POLICY DEVELOP

MRI: ACQUISITION OF A MULTI-PURPOSE CLOUD RADAR

ELUCIDATING THE MECHANISM FOR ALLOSTERIC REGULATION OF SIRT1 THROUGH THE N-TERMINAL REGION - SUMMARY THIS PROJECT AIMS TO ELUCIDATE THE MECHANISM FOR ALLOSTERIC REGULATION OF SIRT1 ACTIVITY VIA THE N-TERMINAL DOMAIN OF SIRT1, A CONFORMATIONALLY DYNAMIC REGION DISTAL TO THE CATALYTIC CORE. SIRT1 IS AN NAD+-DEPENDENT PROTEIN DEACETYLASE WHICH HAS BEEN SHOWN TO PLAY A SIGNIFICANT ROLE IN MANY BIOLOGICAL PATHWAYS, SUCH AS INSULIN SECRETION, TUMOR FORMATION, LIPID METABOLISM AND NEURODEGENERATION. FOR THIS REASON, SIRT1 HAS BEEN IDENTIFIED AS A POTENTIAL THERAPEUTIC TARGET. THIS PROGRESS HAS BEEN HAMPERED BY INSUFFICIENT UNDERSTANDING OF THE MOLECULAR MECHANISM OF THE REGULATION OF SIRT1 ACTIVITY, AS THE C-TERMINAL AND N-TERMINAL DOMAINS WITHIN SIRT1 PLAY COMPLICATED ROLES IN ALLOSTERICALLY AFFECTING SIRT1 ACTIVITY. THE N-TERMINAL DOMAIN HAS BEEN SHOWN TO POTENTIATE SIRT1’S ENZYME ACTIVITY; THIS REGION ALSO CONTAINS THE STAC BINDING DOMAIN (SBD), A BINDING SITE FOR SIRTUIN ACTIVATING COMPOUNDS (STACS). HOWEVER, THERE IS LIMITED IN VITRO BIOCHEMISTRY STUDY REGARDING THE ROLE OF THE N-TERMINAL DOMAIN IN SIRT1 REGULATION. OUR PROJECT IS FOCUSED ON UNDERSTANDING THE ALLOSTERIC INTERACTIONS BETWEEN THE N-TERMINAL DOMAIN AND SIRT1’S CATALYTIC CORE USING THREE INDEPENDENT AIMS AS DETAILED BELOW THAT FOCUS ON THE SUBSTRATE-DEPENDENT REGULATION OF SIRT1 BY RESVERATROL, THE REGULATION OF SIRT1 BY OTHER STACS, AND THE INTRAMOLECULAR REGULATION OF SIRT1 BY MOTIF A, A DOMAIN WITHIN ITS N-TERMINAL REGION. AIM 1: EXAMINE THE ROLE OF COMPLEX STABILITY AND CONFORMATIONAL DYNAMICS IN THE SUBSTRATE-SEQUENCE DEPENDENT REGULATION OF SIRT1 BY RESVERATROL, A WELL-STUDIED STAC. WE WILL COMPARE THE BINDING AFFINITY OF RESVERATROL TO SIRT1 IN THE PRESENCE OF DIFFERENT SUBSTRATES, COMPARE THE STABILITY OF DIFFERENT SIRT1-SUBSTRATE-RESVERATROL COMPLEXES, AND COMPARE THE CONFORMATIONS OF DIFFERENT SIRT1-SUBSTRATE-RESVERATROL COMPLEXES. AIM 2: EXPLORE IF OTHER STACS WITH SIMILAR OR DIFFERENT STRUCTURES AS RESVERATROL CAN ALSO REGULATE SIRT1 IN A SUBSTRATE-SEQUENCE DEPENDENT MANNER. WE WILL CHARACTERIZE THE SUBSTRATE-SEQUENCE DEPENDENT EFFECT OF OTHER STACS, NAMELY PICEATANNOL AND SRT2104 ON SIRT1 ACTIVITY USING ENZYME ACTIVITY ASSAYS AND BINDING ASSAYS. AIM 3: ELUCIDATE THE MECHANISM OF INTRAMOLECULAR SIRT1 REGULATION VIA MOTIF A, AN INTRINSICALLY DISORDERED REGION IN THE N-TERMINUS OF SIRT1 AND THE ROLE OF PHOSPHORYLATION IN THIS REGULATION. WE WILL USE ENZYME ACTIVITY ASSAYS AND BINDING ASSAYS, COMPLEMENTED BY MOLECULAR DYNAMICS SIMULATIONS, TO DETERMINE THE EFFECTS OF PHOSPHORYLATION ON MOTIF A’S ABILITY TO REGULATE SIRT1 ACTIVITY. OUR STUDIES WILL AFFORD A MORE DETAILED UNDERSTANDING OF THE ALLOSTERIC REGULATION OF SIRT1 ELICITED BY THE N- TERMINAL DOMAIN. THIS WOULD CLARIFY HOW THE ACTIVITY OF SIRT1 IS ALTERED IN VARIOUS BIOLOGICAL PATHWAYS AND DISEASE STATES, GUIDING A MORE TARGETED APPROACH IN MODULATING SIRT1 ACTIVITY AS A THERAPEUTIC METHOD.

RINGS: ENABLING JOINT SENSING, COMMUNICATION, AND MULTI-TENANT EDGE AI FOR COOPERATIVE PERCEPTION SYSTEMS -NATIONALLY, 40 PERCENT OF ALL TRAFFIC CRASHES INVOLVE INTERSECTIONS, WITH A QUARTER OF ALL TRAFFIC DEATHS AND ABOUT HALF OF ALL INJURIES OCCURRING IN SUCH LOCATIONS. RECENT ADVANCEMENTS IN VEHICLE COMMUNICATION AND PERCEPTION SYSTEMS HAVE LED TO SIGNIFICANT IMPROVEMENT OF SITUATIONAL AWARENESS IN MODERN CONNECTED AND SEMI-AUTONOMOUS VEHICLES. HOWEVER, THESE LIGHT-BASED PERCEPTION SYSTEMS ARE LIMITED BY VIEW BLOCKAGE IN BUSY TRAFFIC INTERSECTIONS AND THUS CANNOT RELIABLY DETECT ALL OBJECTS. TO IMPROVE SENSING RELIABILITY, MANY AUTONOMOUS SYSTEMS RELY HEAVILY ON MULTIPLE ACTIVE SENSORS INCLUDING 3D LIDAR, RADAR AND ULTRASOUND SENSORS. HOWEVER, THE IMPROVED PERCEPTION RELIABILITY COMES AT THE COST OF BIGGER AND MORE COMPLEX SYSTEMS WITH MULTIPLE VENDOR-SPECIFIC COMPONENTS, WHICH CAUSE MUCH HIGHER POWER CONSUMPTION AND INCREASED MAINTENANCE, SECURITY AND RELIABILITY ISSUES. MOREOVER, THERE ARE NO COORDINATION OR MULTIPLE ACCESS CONTROL MECHANISMS FOR NEARBY ACTIVE SENSORS, THUS POTENTIALLY MAKING NEARBY PERCEPTION SYSTEMS INTERFERE WITH EACH OTHER IN BUSY TRAFFIC INTERSECTIONS. THE GOAL OF THIS PROJECT IS TO DESIGN A NEXT GENERATION SYSTEM WITH MULTI-MODAL SENSING AND LOW-LATENCY COMMUNICATION CAPABILITIES THAT SHARE THE SAME ESSENTIAL HARDWARE INCLUDING THE SPECTRUM BAND, BASEBAND PROCESSING, AND COMPUTING UNITS. THIS DESIGN WILL RESULT IN A LOW-COST AND COMPACT PERCEPTION DEVICE THAT PROVIDES COOPERATIVE SENSING WITH NEARBY DEVICES WITH IMPROVED RESILIENCE. TO IMPROVE THE DEVICE UTILIZATION AND HARNESS THE POWER OF MULTIPLE ARTIFICIAL INTELLIGENCE (AI) SERVICES, THIS PROJECT PROPOSES AN EDGE COMPUTING FRAMEWORK TO ENABLE MULTI-TENANT AI CAPABILITIES ON THE PROPOSED PERCEPTION SYSTEM. THE FEDERAL HIGHWAY ADMINISTRATION (FHA) REPORTS APPROXIMATELY 2.5 MILLION TRAFFIC INTERSECTION ACCIDENTS EVERY YEAR. THE SUCCESSFUL CONCLUSION OF THIS PROJECT WILL ENABLE FUTURE SENSING AND COMMUNICATION SYSTEMS TO COOPERATE WITH THE INFRASTRUCTURE AND NEARBY DEVICES AUTOMATICALLY, DETECTING OBJECTS AND MAPPING BUSY TRAFFIC INTERSECTIONS RELIABLY, THUS DECREASING THE NUMBER OF ACCIDENTS AND FATALITIES. THE PROPOSED JOINT SENSING AND COMMUNICATION SYSTEM WILL SERVE AS A WELL-ROUNDED, REFERENCE DESIGN FOR THE DEVELOPMENT COMMUNITY TO USE IN FUTURE CONNECTED AND SENSING SYSTEMS. THE PROPOSED COOPERATIVE SENSING MECHANISM WILL HELP LOWER THE COST OF INDIVIDUAL DEVICES WHILE AT THE SAME TIME ACHIEVING HIGHER RESILIENCE AND MINIMIZING INTERFERENCE BETWEEN NEARBY SYSTEMS. THE PROPOSED RESEARCH WILL ALSO LOWER BARRIERS FOR UNDERGRADUATE AND K-12 STUDENTS (ESPECIALLY UNDERREPRESENTED GROUPS) TO LEARN INTELLIGENT EMBEDDED SYSTEMS DESIGN, INTERNET-OF-THINGS, AND AI SYSTEMS WHILE ACCESSING STATE-OF-THE-ART EDGE-COMPUTING LAB SYSTEM SETTINGS WITH REMOTE TESTING, DEPLOYMENT, MONITORING, ORCHESTRATION, AND OVER-THE-AIR PROGRAMMING CAPABILITIES. THE LESSONS LEARNED AND SYSTEM DEVELOPED IN THIS PROJECT WILL SERVE AS A PLUG-AND-PLAY RESILIENT NEXT-GENERATION NETWORKING SOLUTION TO UNLOCK MORE INNOVATIVE FUTURE 5G/6G PROJECTS AND IDEAS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

CAREER: RE-EVALUATING THE EVOLUTION OF THE SOUTHERN SAN ANDREAS FAULT ALONG ITS RESTRAINING BEND FROM HOLOCENE TO MID-QUATERNARY TIMESCALES VIA 36CL/10BE BURIAL AND COSMOGENIC...

CHARACTERIZATION OF THE LUNAR DUST ENVIRONMENT FOR HUMAN EXPLORATION AND AS A TRACER OF THE HISTORY OF ORGANICS IN THE SOLAR SYSTEMWE PROPOSE TO ST

NEW BUILDING FOR MOSS LANDING MARINE LABORATORY: TO STUDY AND PLAN PROJECT FEASIBILITY, SCHEDULING, AND CONSTRUCTION, SPECIALISTS TO PERFORM GEOTECHNICAL AND ENVIRONMENTAL ASSESSMENTS, AN ARCHITECTURAL ENGINEER, AND A PERMITTING SPECIALIST. THE GOAL OF THIS PROJECT IS TWOFOLD: TO PLAN AND STRENGTHEN THE ENTIRE SITE AGAINST PROJECTED SEA LEVEL RISE, MAKE THE ASSETS MORE RESILIENT, INCLUDING TO MORE FREQUENT AND STRONGER STORMS, AND SPEARHEAD THE DEVELOPMENT OF A WORKING WATERFRONT THAT WILL BE A COMMERCIAL ASSET TO THE REGION.

COLLABORATIVE: BENTHIC-PELAGIC COUPLING IN AN INTACT ECOSYSTEM: THE ROLE OF TOP PREDATORS IN MCMURDO SOUND

FUNDAMENTAL SURFACE SCIENCE OF NANOSCALE DIAMOND AND THEIR INTERACTION WITH BIOLOGICAL SURFACES

THIS PROJECT AIMS TO COMPARE AND VALIDATE A NEW LOW-COST DIGITAL HOLOGRAPHY BASED CELL IMAGING PLATFORM (AQUSENS) AGAINST THE IMAGING FLOW CYTOBOT (IFCB) TOWARDS INCREASING CAPACITY BUILDING FOR HARMFUL ALGAL BLOOM (HAB) CELL DETECTION WITHIN THE CONTEXT OF ROUTINE MONITORING AND TARGETED DEPLOYMENTS. PLATFORMS THAT DETECT HAB CELLS HAVE PROVEN INVALUABLE FOR EARLY WARNING OF POTENTIALLY PROBLEMATIC SPECIES (E.G. FLOWCAM, IFCB). THESE INSTRUMENTS CAN MONITOR TRENDS IN CELL CONCENTRATIONS SUCH THAT LOCAL AND REGIONAL MANAGEMENT DECISIONS CAN BE MADE PROACTIVELY VERSUS REACTIVELY. THE IFCB IS FIELD DEPLOYABLE FOR NEAR REAL-TIME IN SITU DETECTION, HOWEVER BROADER ADOPTION INTO MONITORING PROGRAMS, EXISTING NETWORKED PLATFORMS, AND SMALLER ENTITIES (E.G. AQUACULTURE FACILITIES, AQUARIUMS, TARGETED FISHERIES) HAS BEEN HAMPERED BY COST AND EXPERTISE REQUIRED FOR OPERATION, MAINTENANCE, SERVICING AND TROUBLESHOOTING. RECENTLY, AN EXPANDED NETWORK OF TEN IFCB'S WAS ESTABLISHED ALONG

ADVANCING THE UNDERSTANDING OF CLOUD MICROPHYSICAL PROCESSES AND AEROSOL INDIRECT EFFECTS IN HIGH-LATITUDE MIXED-PHASE CLOUDS BY LINKING ARM MEASUREMENTS WITH CLIMATE MODEL SIMULATIONS

RESEARCH INFRASTRUCTURE: CC* COMPUTE-CAMPUS: A CAMPUS-WIDE COMPUTING RESOURCE FOR RESEARCH AND TEACHING AT SAN JOSE STATE UNIVERSITY -SAN JOS? STATE UNIVERSITY (SJSU) RESEARCH ACTIVITIES ARE EXPANDING AT AN ACCELERATED PACE. INTERDISCIPLINARY RESEARCH ACROSS NUMEROUS FIELDS HAS SIGNIFICANT COMPUTATIONAL DEMANDS THAT OUTSTRIP CURRENT HIGH-PERFORMANCE COMPUTING (HPC) CAPACITY, DIRECTLY IMPACTING THE PRODUCTIVITY AND EFFECTIVENESS OF THE ACADEMIC COMMUNITY. THESE COORDINATED, CAMPUS-LEVEL CYBERINFRASTRUCTURE IMPROVEMENTS ADDRESS THIS CRITICAL INFRASTRUCTURE GAP, SUPPORTING RESEARCHERS IN COLLEGES, DEPARTMENTS, AND RESEARCH CENTERS ACROSS THE INSTITUTION, AND FURTHER ACCELERATING SJSU?S INTERDISCIPLINARY RESEARCH AND EDUCATION EFFORTS. THE HPC ENVIRONMENT PLAYS A CRITICAL ROLE IN SUPPORTING AND INCREASING THE DIVERSITY OF SJSU, AN MSI, PUI, AND AANAPISIS. IT ALSO RAISES THE QUANTITY OF RESEARCH AND EDUCATIONAL OPPORTUNITIES, PROVIDING EXCELLENT HANDS-ON LEARNING EXPERIENCES FOR UNDERREPRESENTED STUDENT POPULATIONS, AIDING IN EFFORTS TO RECRUIT AND RETAIN FACULTY ENGAGED IN INNOVATIVE COMPUTATIONAL RESEARCH, AND SUPPORTING LONG-TERM CROSS-INSTITUTIONAL COLLABORATION. THIS AWARD ESTABLISHES THE SJSU ENTERPRISE HPC CLUSTER, WHICH FEATURES HIGH-END NVIDIA GPU NODES (8 H100 AND 8 L40S GPUS) AND 400TB OF HIGH-PERFORMANCE SSD STORAGE. THIS NEW CLUSTER DOES NOT SIMPLY REPLACE EXISTING EQUIPMENT. IT SIGNIFICANTLY IMPROVES SPEED AND CAPABILITY TO SERVE RESEARCHERS AND STUDENTS CAMPUS-WIDE, NOTABLY ENHANCING RESEARCH PRODUCTIVITY AND EDUCATIONAL CURRICULA BY PROVIDING THREE TIMES THE PERFORMANCE COMPARED TO EXISTING GPU CAPACITIES. THESE RESOURCES, OPTIMIZED FOR ACCELERATING GROWING AREAS OF DATA-INTENSIVE RESEARCH AT SJSU, INCLUDING AI/ML, QUANTUM SCIENCE AND MATERIAL SCIENCE, COMPUTATIONAL ACOUSTICS AND MECHANICS, METAMATERIAL DESIGN, BIOINFORMATICS, COMPUTATIONAL CHEMISTRY, SPATIAL SCIENCES, AND MORE, WILL SIGNIFICANTLY IMPROVE THE SPEED AND CAPABILITY NEEDED TO MEET RESEARCH AND EDUCATIONAL DEMANDS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO RECEIVED THIS GRANT WHICH WAS TRANSFERRED TO THE SAN JOSE STATE UNIVERSITY. THE SAN JOSE STATE UNIVERSITY, IN PARTNERSHIP WITH THE NATIONAL HEAD START ASSOCIATION AND REPRESENTATIVES FROM EACH OF THE FIVE READING NATION CHAPTERS - CROW (MONTANA), EASTERN BAND OF CHEROKEE (NORTH CAROLINA), LUMBEE (NORTH CAROLINA), NORTHERN CHEYENNE (MONTANA), AND SANTO DOMINGO PUEBLO (NEW MEXICO) - WILL INCREASE ACCESS TO LITERARY RESOURCES AND LIBRARIES FOR NATIVE AMERICAN CHILDREN AND FAMILIES. THE ANTICIPATED OUTCOMES OF THE PROJECT WILL BE INCREASED CONVENIENCE AND ACCESS TO FREE, LIBRARIAN-CURATED CHILDREN'S BOOKS FOR NATIVE AMERICAN CHILDREN, INCREASED CULTURALLY RELEVANT LIBRARY PROGRAMMING AND RESOURCES, AND THE FORMATION OF STRATEGIC LOCAL PARTNERSHIPS BETWEEN CROSS-DISCIPLINARY ORGANIZATIONS WORKING TOGETHER TO IMPROVE LITERACY. IN PARTNERSHIP WITH LOCAL AND NATIONAL LIBRARY ASSOCIATIONS AND COMMUNITY ORGANIZATIONS, THE PROJECT ALSO WILL DEVELOP AND DISSEMINATE A NATIVE AMERICAN LITERACY AND LIBRARY MODEL THAT CAN BE REPLICATED.

RESEARCH AND TEACHING SCHOLARS

ENGINEERING LEADERSHIP PATHWAY SCHOLARS 2 PROGRAM

POLYCYCLIC AROMATIC HYDROCARBONS (PAHS), A COMMON AND IMPORTANT RESERVOIR OF ACCESSIBLE CARBON ACROSS THE UNIVERSE, PLAY AN INTRINSIC PART IN THE FOR

ACQUISITION OF AN AUTOMATED MULTIPURPOSE FURNACE AND REACTIVE ION ETCHER SYSTEM FOR MICROSCALE FABRICATION EDUCATION AND RESEARCH AT SJSU

RET SITE: MULTIDISCIPLINARY TEACHER RESEARCH EXPERIENCE IN ENGINEERING (M-TREE)

UNDERSTANDING WHAT PROPERTIES OF SKILLS AND KNOWLEDGE (S&K) SUPPORT USEFUL GENERALIZATION AND LONG-TERM RETENTION IS CRITICAL TO THE SUCCESS OF FUTUR

CISE MSI: RDP: IIS: HCC: DEMONSTRATING MIXED REALITY AND EDGE COMPUTING IN HUMAN-ROBOT INTERACTION AND COLLABORATION CONSIDERING HUMAN FACTORS -THE NEED FOR ROBUST, RESILIENT, AND SUSTAINABLE CYBERINFRASTRUCTURE FOR HUMAN-ROBOT INTERACTION AND COLLABORATION HAS SURGED, EMPHASIZING THE IMPORTANCE OF HUMAN-CENTERED COMPUTING (HCC). HOWEVER, CURRENT METHODS STRUGGLE TO ADDRESS THE COMPLEX DYNAMICS OF HUMANS AND ROBOTS, PARTICULARLY WHEN CONSIDERING HUMAN BEHAVIOR, MUTUAL IMPACTS BETWEEN HUMANS AND ROBOTS, PHYSICAL INTERACTIONS, USER PERCEPTIONS, AND POTENTIAL ASSOCIATED RISKS. BY LEVERAGING MIXED REALITY, DEVELOPING NEW ALGORITHMS IN EDGE COMPUTING, AND PARTNERING WITH SOCIAL SCIENTISTS ON PSYCHOLOGICAL AND ETHICAL IMPACTS, THE DEMONSTRATION PROJECT AIMS TO ENABLE IMMERSIVE, CONTEXT-AWARE EXPERIENCES THAT ENHANCE THE ABILITIES OF HUMANS AND ROBOTS TO PERCEIVE, UNDERSTAND, AND COLLABORATE MORE EFFECTIVELY. THROUGH RESEARCH FINDINGS, THE TEAM SEEKS TO ENHANCE SAN JOS? STATE UNIVERSITY?S RESEARCH CAPACITY ACROSS MULTIPLE DOMAINS HUMAN-ROBOT AREAS AND HCC. THIS PROJECT BUILDS RESEARCH CAPACITY, SUSTAINABLE FOR TRAINING UNDERREPRESENTED STUDENTS VIA MULTIDISCIPLINARY COLLABORATION AND PARTNERSHIP WITH LOCAL COMPANIES. KEY PROJECT OUTCOMES INCLUDE PIONEERING IMMERSIVE EXPERIENCES THROUGH INTEGRATING MR, HAPTIC FEEDBACK MECHANISMS, AND WEARABLES INTO INTERACTIVE PHYSICAL-BASED HRI ENVIRONMENTS. ADDITIONALLY, THE PROJECT SIGNIFICANTLY ADVANCES ROBOTIC COGNITIVE ABILITIES AND PROMOTES INTUITIVE, INTELLIGENT INTERACTIONS WITH HUMANS. THIS PROJECT FOCUSES ON THREE PRIMARY RESEARCH OBJECTIVES (1) FORGING IMMERSIVE AND CONTEXT-AWARE EXPERIENCES FOR HUMAN PSYCHOLOGICAL AND ETHICAL STUDY. USING MR TO SIMULATE AN EMERGENCY DEPARTMENT ENVIRONMENT TO ENHANCE UNDERSTANDING OF ETHICAL CONSIDERATIONS AND PHYSIOLOGICAL IMPACTS IN HUMAN-ROBOT CONTEXTS; (2) EMPOWERING ROBOTS WITH ENHANCED PERCEPTION, COMPREHENSION, AND INTERACTION CAPABILITIES WITH THEIR ENVIRONMENT. MULTI-PERCEPTUAL SENSORIMOTOR INTERACTIONS IN THE MR SIMULATION ENHANCE ROBOTS' ABILITY TO DYNAMICALLY SENSE AND RESPOND IN SIMULATED EMERGENCY DEPARTMENT SCENARIOS, IMPROVING THEIR HEALTHCARE-RELATED TASK PERFORMANCE; (3) IMPROVING SEAMLESS COMMUNICATION BETWEEN HUMANS AND ROBOTS. AN TAILORED EDGE COMPUTING ARCHITECTURE IS DESIGNED AND IMPLEMENTED TO FACILITATE REAL-TIME DATA PROCESSING AND COMMUNICATION BETWEEN HUMANS AND ROBOTS, OPTIMIZING INTERACTION PATHWAYS AND TASK DISTRIBUTION TO ENHANCE PATIENT CARE OUTCOMES IN CRITICAL SITUATIONS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

ENGINEERING LEADERSHIP PATHWAY SCHOLARS PROGRAM

SILICON VALLEY INNOVATION & ENTREPRENEURSHIP SCHOLARSHOPS (SVIES) PROGRAM

SCHOLARS IN SCIENCE

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING (BHWET) PROGRAM

IN SITU SAMPLING OF THERMODYNAMICS AND FOG AT THE AIR-SEA INTERFACE

CAREER: RUI: UNDERSTANDING HUMAN COGNITION IN COMPUTER NETWORK DEFENSE

EFFECTS OF OCEAN CLIMATE CHANGE ON RECRUITMENT OF KELP POPULATIONS

ADAPTIVE EVOLUTION OF CANDIDA BIOFILMS - PROJECT SUMMARY THERE IS A CRITICAL NEED TO IDENTIFY IMPORTANT PARAMETERS INVOLVED IN ADAPTATION TO ENVIRONMENTAL STRESSES IN FUNGAL BIOFILMS, IN ORDER TO DEVELOP EFFECTIVE THERAPEUTIC STRATEGIES AGAINST FUNGAL INFECTIONS. TREATMENT OF FUNGAL INFECTIONS BY CANDIDA SPP, INCLUDING THE EMERGING PATHOGEN CANDIDA GLABRATA (C. GLABRATA), REMAINS A CLINICAL CHALLENGE ESPECIALLY IN IMMUNOCOMPROMISED INDIVIDUALS. C. GLABRATA IS NOW THE SECOND MOST FREQUENTLY ISOLATED CANDIDA SPP IN NORTH AMERICA. IN VIVO, MICROBES MOSTLY EXIST IN BIOFILMS, WHICH SERVE AS PROTECTIVE LAYERS. CELLS IN BIOFILMS EXHIBIT INCREASED RESISTANCE TO ENVIRONMENTAL STRESSES. SINCE BIOFILMS ARE AN INTEGRAL PART OF PATHOGENESIS, THE ADAPTATION OF FUNGAL PATHOGENS INSIDE A BIOFILM IS AN IMPORTANT ASPECT THAT REQUIRES A DEEPER UNDERSTANDING. HOWEVER, EXISTING KNOWLEDGE OF FUNGAL ADAPTATION IN BIOFILMS IS LIMITED, PARTLY DUE TO THE LACK OF ESTABLISHED EXPERIMENTAL METHODS FOR THE LONG-TERM PROPAGATION OF FUNGAL BIOFILMS. WITH A LONG-TERM GOAL OF CONTRIBUTING TO THE DEVELOPMENT OF THERAPEUTIC STRATEGIES FOR CANDIDIASIS, THE OVERALL OBJECTIVE OF THE PROJECT IS TO DEVELOP A FUNGAL BIOFILM PROPAGATION METHOD FOR USE IN EXPERIMENTAL ADAPTIVE EVOLUTION, AND TO APPLY THE SYSTEM TO IDENTIFY ESSENTIAL GENES INVOLVED IN C. GLABRATA BIOFILMS. IN AIM 1, A BIOFILM CULTURE SYSTEM SUITABLE FOR LONG- TERM IN VITRO EVOLUTION WILL BE DEVELOPED AND CHARACTERIZED. A KEY FEATURE OF THE METHOD BEING DEVELOPED IS THE ABILITY TO GROW MULTIPLE BIOFILMS FROM THE SAME SEED BIOFILM, ALLOWING MULTIPLE PROCEDURES FOR ANALYSIS AND CHARACTERIZATION OF BIOFILMS AT EACH PASSAGE DURING IN VITRO EVOLUTION. AIM 2 WILL IMPLEMENT THE FUNGAL BIOFILM PROPAGATION SYSTEM FOR IN VITRO EVOLUTION OF C. GLABRATA TO ENVIRONMENTAL STRESSORS. KEY PROPERTIES, SUCH AS AMOUNT OF BIOFILM FORMATION AND CHANGES IN BIOFILM STRUCTURE WILL BE MONITORED. MOLECULAR MECHANISMS ASSOCIATED WITH ADAPTATION TO ENVIRONMENTAL STRESSORS IN FUNGAL BIOFILMS WILL BE ELUCIDATED BASED ON GENOME- SEQUENCING AND PHENOTYPIC ANALYSES. AIM 3 WILL COMBINE THE BIOFILM PROPAGATION METHOD WITH TRANSPOSON SEQUENCING TO IDENTIFY ESSENTIAL GENES INVOLVED IN BIOFILM FORMATION IN C. GLABRATA. THE METHOD BEING DEVELOPED CAN BE BROADLY APPLIED TO OTHER MICROBIAL PATHOGENS TO BETTER IDENTIFY HOW PATHOGENS ADAPT AND EVOLVE IN A MORE HOST-RELEVANT ENVIRONMENT, AND ENABLES THE IDENTIFICATION OF POTENTIAL THERAPEUTIC STRATEGIES AGAINST DIFFICULT-TO- TREAT BIOFILMS. THIS R16 WILL FUND THE RESEARCH OF APPROXIMATELY 20 UNDERGRADUATES (UGS) OVER FOUR YEARS, INCLUDING MANY MINORITY TRAINEES. UGS WILL PERFORM THE MAJORITY OF THE PROPOSED WORK, WITH TRAINING AND MENTORSHIP FROM A TECHNICIAN AND THE PI. THIS FUNDING WOULD ALLOW THE PI TO CONTINUE TO DEVELOP A STRONG TRACK RECORD IN RESEARCH, GIVE MEANINGFUL RESEARCH EXPERIENCES TO UNDERREPRESENTED MINORITY STUDENTS, AND ENHANCE THE RESEARCH CAPACITY AT SAN JOSE STATE UNIVERSITY.

SHIPBOARD SCIENTIFIC SUPPORT EQUIPMENT

CAREER: MORAL ECONOMIES IN WATER MARKETS: IMPLICATIONS FOR UNDERSTANDING HUMAN RESPONSES TO WATER INSECURITY -HALF OF THE WORLD?S POPULATION WILL LIVE IN WATER-STRESSED CONDITIONS BY 2040. TO MANAGE WATER INSECURITY, MANY COMMUNITIES WILL INCREASINGLY NEED TO RELY ON MOBILE, ADAPTABLE, AND DECENTRALIZED WATER INFRASTRUCTURES, SUCH AS PRIVATE WATER VENDING, RATHER THAN ON CENTRALIZED PUBLIC SYSTEMS ALONE. IN THE COMING YEARS THEN, IT WILL BE CRUCIAL TO UNDERSTAND HOW MARKET-BASED INFRASTRUCTURES CAN BE DESIGNED TO UPHOLD LOCAL NOTIONS OF WATER JUSTICE AND ADVANCE THE HUMAN RIGHT TO WATER. THIS CAREER PROJECT WILL EXAMINE WHEN AND HOW COMMUNITIES MOBILIZE MARKET-BASED MORAL ECONOMIES TO MANAGE WATER INSECURITY IN WAYS THEY CONSIDER TO BE FAIR AND JUST. MORAL ECONOMIES ARE NORMATIVE ECONOMIC INSTITUTIONS IN WHICH SHARED NOTIONS OF JUSTICE OBLIGATE INDIVIDUALS TO PROVIDE ACCESS TO VITAL RESOURCES. WHILE SCIENTISTS HAVE DOCUMENTED RECIPROCITY-BASED MORAL ECONOMIES AS A KEY HUMAN RESPONSE TO RESOURCE INSECURITY, WE HAVE LITTLE UNDERSTANDING OF WHEN AND HOW PEOPLE MAY USE MARKET-BASED MORAL ECONOMIC ARRANGEMENTS TO MANAGE WATER INSECURE CONDITIONS WITHIN CONTEMPORARY CAPITALIST CONTEXTS. IN PHASE 1 OF THE PROJECT, THE RESEARCHER WILL ETHNOGRAPHICALLY EXAMINE PRIVATE WATER VENDING IN A MAJOR U.S. WATER INSECURITY HOTSPOT TO UNDERSTAND IF AND WHEN MARKET-BASED MORAL ECONOMIES FOR WATER ARISE. IN PHASE 2, THE RESEARCHER WILL EXPLORE THE GENERALIZABILITY OF THESE FINDINGS THROUGH A CROSS-CULTURAL STUDY OF MARKET-BASED MORAL ECONOMIES IN SIX GLOBAL SITES (VIA COLLABORATION WITH THE NSF-FUNDED HOUSEHOLD WATER INSECURITY RESEARCH COORDINATION NETWORK). BOTH PHASES OF RESEARCH WILL FOCUS ON THREE WATER MARKETS (INFORMAL EXCHANGES, SEMI-FORMAL WATER HAULING, AND FORMAL WATER RETAIL STORES) TO EXAMINE HOW MARKET FORMALITY ENABLES OR CONSTRAINS MORAL ECONOMIES FOR WATER. WITHIN EACH MARKET, THE RESEARCHER WILL EXAMINE HOW SOCIAL DISTANCE, DYADIC SOCIAL TIES THAT ARE STRONG, WEAK, OR ABSENT, ENABLES OR CONSTRAINS MORAL ECONOMIES FOR WATER. FINDINGS FROM THIS RESEARCH WILL: CONTRIBUTE TO ANTHROPOLOGICAL KNOWLEDGE OF THE SOCIAL FOUNDATIONS OF MARKETS; FURTHER UNDERSTAND HOW HUMANS RESPOND TO RESOURCE INSECURITY IN MARKET-BASED ECONOMIES; ADVANCE INTERDISCIPLINARY SCHOLARSHIP ON THE MULTI-SCALAR CAUSES, CONSEQUENCES, AND RESPONSES TO HOUSEHOLD WATER INSECURITY. FUNDING FOR THE PROJECT WILL ALSO SUPPORT THE DEVELOPMENT OF A NOVEL RESEARCH APPRENTICESHIP MODEL THAT WILL INTEGRATE ALL PHASES OF RESEARCH WITH GRADUATE AND UNDERGRADUATE TEACHING IN ORDER TO TRAIN A NEW GENERATION OF SOCIAL SCIENTISTS IN TEAM-BASED INTERDISCIPLINARY SOCIAL SCIENCE AND COMMUNITY-BASED RESEARCH METHODS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

OCEANOGRAPHIC TECHNICAL SERVICES, 2009 - 2011, R/V POINT SUR

CAREER: SCALABLE AND ADAPTABLE SPARSITY-DRIVEN METHODS FOR MORE EFFICIENT AI SYSTEMS -ARTIFICIAL INTELLIGENCE (AI) AND, IN PARTICULAR, DEEP NEURAL NETWORKS (DNN) HAVE ACHIEVED BETTER THAN HUMAN ACCURACY ON MANY COGNITIVE TASKS INVOLVING IMAGES, NATURAL LANGUAGE PROCESSING, AND PROTEIN STRUCTURE, AMONG OTHERS. UNFORTUNATELY, DUE TO HIGH DATA PROCESSING DEMANDS, AI SYSTEMS ARE TYPICALLY RUN ON POWER-HUNGRY SPECIALIZED COMPUTING HARDWARE. QUANTIZATION, OR APPROXIMATION TO SMALLER NUMERICAL VALUES, HAS BEEN USED TO REDUCE COMPUTING REQUIREMENTS. HOWEVER, THE FIXED LOW BIT-WIDTH DNNS MAY SUFFER LOSSES IN ACCURACY DUE TO QUANTIZATION ERRORS. MANY EXISTING SOFTWARE SOLUTIONS FOR QUANTIZATION ARE ALSO FIXED OR LIMITED IN BIT-WIDTH CHOICES. TO ADDRESS THIS TRADE-OFF AND LEVERAGE DATA SPARSITY, THE RESEARCH TEAM WILL INVESTIGATE STATE-OF-THE-ART METHODS AND DEVELOP NOVEL DATA QUANTIZATION, ENCODING, AND COMPRESSION ALGORITHMS TO INTEGRATE WITH EXISTING AI SYSTEMS. THE METHODS DEVELOPED HAVE THE POTENTIAL TO NOT ONLY IMPROVE PERFORMANCE BUT ALSO TO REDUCE POWER REQUIREMENTS AND BOOST THE ENERGY EFFICIENCY OF AI SYSTEMS. THEY WILL ENABLE AI APPLICATIONS SUCH AS DNN INFERENCE ON SMALL DEVICES, THUS REDUCING THE LOAD ON CLOUD INFRASTRUCTURE, IMPROVING USER EXPERIENCE, PROVIDING DATA PRIVACY, AND AVOIDING SECURITY RISKS. THE WORK PROPOSED IN THIS PROJECT HAS THE POTENTIAL TO PUSH THE BOUNDARIES IN MANY AI APPLICATIONS THAT RUN ON ENERGY STORAGE-CONSTRAINED DEVICES, SUCH AS SMART SENSING, WEARABLE DEVICES, AND AUTONOMOUS DRIVING. THE RESEARCH AND EDUCATIONAL TOOLS WILL FACILITATE AND INCREASE STUDENT AND RESEARCH COMMUNITY PARTICIPATION IN ADVANCING AI RESEARCH. THE WORK WILL BE CONDUCTED AT A MINORITY-SERVING INSTITUTION, AND THE FUNDING WILL SUPPORT STUDENTS FROM UNDERREPRESENTED GROUPS. THE RESEARCH GOAL OF THIS PROJECT IS TO INVESTIGATE QUANTIZATION AND COMPRESSION METHODS THAT CAN LEVERAGE SPARSITY AND IMPROVE EFFICIENCY IN AI SYSTEMS. THE PRINCIPAL INVESTIGATOR (PI) PLANS TO STUDY ADAPTABLE QUANTIZATION AND COMPRESSION METHODS TO LEVERAGE SPARSITY IN AI SYSTEMS WHILE MINIMIZING THE OVERHEAD IN NON-SPARSE SITUATIONS AND MINIMIZING ACCURACY LOSS. THE TRADE-OFF BETWEEN ACCURACY AND PERFORMANCE WITH THE PROPOSED METHODS WILL BE STUDIED AND DEFINED FOR AUTOMATED TUNABLE PRIORITIZATION OF EITHER ACCURACY, PERFORMANCE, OR ENERGY EFFICIENCY. THE PI PLANS TO DEVELOP A PROTOTYPE WITH PARALLEL EXECUTION OF THE PROPOSED METHODS TO MAKE THE PROPOSED METHODS TRULY EFFECTIVE FOR DATA CENTERS AND ADVANCED HARDWARE ARCHITECTURES. THE PROPOSED METHODS WILL BE PACKAGED INTO AN AI VECTOR PRIMITIVES LIBRARY THAT WILL BE INTEGRATED WITH SEVERAL POPULAR DEEP LEARNING FRAMEWORKS AS PROOF OF CONCEPT, PRIMARILY TARGETING GPU AND CPU SYSTEMS. AN INTEGRATION API WILL BE DEVELOPED FOR FRAMEWORKS LIKE PYTORCH OR TENSORFLOW TO ALLOW EASY INTEGRATION WITH OTHER VECTOR PRIMITIVES. SOFTWARE LIBRARIES WILL BE INTEGRATED WITH A WEB-BASED LEARNING PLATFORM WITH AUTOMATED FEEDBACK AND A MOTIVATING ENVIRONMENT TO ENCOURAGE STUDENT PARTICIPATION IN SOLVING AI CHALLENGES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

EQUIPMENT: MRI: TRACK 1 ACQUISITION OF A TIP-ENHANCED RAMAN SPECTROSCOPE FOR RESEARCH AND EDUCATION AT SAN JOSE STATE UNIVERSITY -NON-TECHNICAL DESCRIPTION: THE ACQUISITION OF A TIP-ENHANCED RAMAN SPECTROSCOPE AT SAN JOSE STATE UNIVERSITY (SJSU) CAN SIGNIFICANTLY IMPROVE OUR UNDERSTANDING OF NANOMETER-SCALE MATERIALS AND FOSTER HANDS-ON LEARNING EXPERIENCES FOR UNDERGRADUATE AND MASTER'S STUDENT RESEARCHERS. THE TEAM AT SJSU UTILIZES THIS OPTICAL INSTRUMENT TO TACKLE SCIENTIFIC CHALLENGES ON MATERIALS SCIENCE, WITH THE MATERIALS FOR POTENTIAL APPLICATIONS IN TRANSPORTATION, ENERGY STORAGE, ELECTRONICS, AND HEALTH SCIENCE. IN ADDITION, THE INSTRUMENT FACILITATES COLLABORATION WITH EXTERNAL USERS IN THE AREA, INCLUDING CALIFORNIA STATE UNIVERSITY - EAST BAY AND THE UNIVERSITY OF CALIFORNIA - MERCED. THE ACQUISITION ALSO AIMS TO ADVANCE HIGH-QUALITY PUBLIC EDUCATION FOR STUDENTS, INCLUDING THOSE IN UNDERREPRESENTED GROUPS, THEREBY CULTIVATING A HIGHLY TRAINED AND DIVERSE SCIENCE AND ENGINEERING WORKFORCE IN THE UNITED STATES. TECHNICAL DESCRIPTION: THE ACQUIRED TIP-ENHANCED RAMAN SPECTROSCOPE INTEGRATES SCANNING PROBE MICROSCOPY AND RAMAN SPECTROSCOPY, ENABLING SCIENTISTS TO DETERMINE MOLECULAR FINGERPRINTS AND TOPOGRAPHY OF NANOMATERIALS DOWN TO 10 NANOMETER SPATIAL RESOLUTION, WHICH IS A RESOLUTION LEVEL THAT COULD NOT BE ACHIEVED USING TRADITIONAL OPTICAL MEASUREMENT TECHNIQUES. THIS COMBINED ANALYSIS TECHNIQUE IS ALSO LESS INVASIVE THAN SOME OF THE OTHER TECHNIQUES BASED ON ELECTRON BEAMS OR X-RAYS, MINIMIZING THE SAMPLE DAMAGE AND MISINTERPRETATION OF THE CHEMICAL AND PHYSICAL PROPERTIES OF NANOMATERIALS. THE RESEARCHERS AT SJSU APPLY THIS ANALYSIS TECHNIQUE TO STUDY QUANTUM DOT COMPOSITES, BIOMATERIALS-DRIVEN INTERPHASE IN BATTERIES, QUANTUM COHERENCE PROPERTIES IN NANODIAMONDS, THE EFFECTS OF STRAIN MANIPULATION ON TRANSITION METAL DICHALCOGENIDE HETEROSTRUCTURES, AND THE EFFECTS OF SURFACE DIPOLE MOMENTS ON NITROGEN-VACANCY CENTERS FOR QUANTUM SENSING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

CIRRUS CLOUDS ARE ONE OF THE MAIN COMPONENTS CONTRIBUTING TO LARGE UNCERTAINTIES IN PREDICTION OF FUTURE CLIMATE. THEY ARE LOCATED AT THE UPPER TROPOSPHERE/LOWER STRATOSPHERE WHERE THE ATMOSPHERE IS MOST SENSITIVE TO CHANGES IN HUMIDITY AND THEY ALSO DIRECTLY AFFECT MOISTURE CONTENT AND CHEMICAL PROCESSES IN THAT VERTICAL LAYER.

TRUNCATED INOSITOL GLYCANS AND CANCER

PROBING AMYLOID FIBRIL SELF-ASSEMBLY WITH NETWORK HAMILTONIAN SIMULATIONS IN EXPLICIT SPACE - PROJECT SUMMARY/ABSTRACT AMYLOID FIBRIL FORMATION IS CENTRAL TO THE DISEASE ETIOLOGY OF A NUMBER OF HUMAN DISEASES, INCLUDING ALZHEIMER’S DISEASE, TYPE 2 DIABETES, AND A VARIETY OF PRION DISEASES. ALTHOUGH MOLECULAR STRUCTURES FOR THOUSANDS OF AMYLOID FIBRILS HAVE BEEN RESOLVED USING TECHNIQUES LIKE X-RAY CRYSTALLOGRAPHY AND NUCLEAR MAGNETIC RESONANCE (NMR), THE MECHANISM OF AMYLOID FIBRIL FORMATION IS LARGELY UNKNOWN. THE MECHANISM OF PRIMARY NUCLEATION, WHEREBY FIBRIL FORMATION BEGINS IN A SOLVENT ENVIRONMENT THAT PREVIOUSLY DID NOT CONTAIN ANY AMYLOID FIBRILS, A CRUCIAL STEP IN AMYLOID DISEASE ONSET, IS PARTICULARLY MYSTERIOUS. DYE-BINDING FLUORESCENCE MICROSCOPY EXPERIMENTS HAVE BEEN USED TO OBSERVE THE SPONTANEOUS FORMATION FIBRIL FORMATION IN MICROFLUIDIC CHAMBERS FROM INDIVIDUAL PRIMARY NUCLEATION SITES. THESE EXPERIMENTS REVEALED TWO KEY MECHANISTIC DETAILS: 1) FIBRIL FORMATION PROPAGATED THROUGH SOLUTION AS A TRAVELING WAVE OF CONSTANT VELOCITY MOVING AWAY FROM THE PRIMARY NUCLEATION SITE, AND 2) THERE EXISTS A LINEAR RELATIONSHIP BETWEEN THE LAG TIME BEFORE FIBRIL FORMATION AND THE INVERSE OF VOLUME. WE HYPOTHESIZE THAT THE CONFINEMENT OF INSULIN TO SMALLER VOLUMES IS AN EVOLUTIONARY ADAPTATION THAT RENDERS AMYLOID FIBRIL FORMATION PROHIBITIVELY SLOW, IN TURN, INFLUENCING THE SIZE OF INSULIN GRANULES IN PANCREATIC BETA CELLS. WE WILL DEVELOP NOVEL TOP-DOWN COARSE-GRAINED MODEL THAT UTILIZE A BRIDGED APPROACH, WHEREBY TWO REPRESENTATIONS OF AN ENSEMBLE OF FIBRIL-FORMING PROTEINS (ONE PURELY TOPOLOGICAL NETWORK REPRESENTATION AND ONE GRANULAR REPRESENTATION IN EXPLICIT SPACE) EXCHANGE INFORMATION AS TIME EVOLVES. THIS APPROACH WILL LEVERAGE THE HIGH COMPUTATIONAL EFFICIENCY OF EXPONENTIAL-FAMILY RANDOM GRAPH MODELS (PURELY TOPOLOGICAL), WITH IMPROVED SPATIAL REALISM PROVIDED BY A MINIMAL EXPLICIT SPACE MODEL BASED ON A LENNARD-JONES FLUID. THE MODELS WILL FIRST BE FIT USING A THREEFOLD VALIDATION STRATEGY WHEREBY THEY WILL BE PARAMETERIZED TO SIMULTANEOUSLY REPRODUCE THREE KNOWN EXPERIMENTAL OBSERVABLES: THE FIBRIL’S TOPOLOGICAL STRUCTURE (DERIVED FROM STRUCTURES REPORTED IN THE PROTEIN DATA BANK), FIBRIL GROWTH KINETICS (COMPARED TO DYE- BINDING FLUORESCENCE EXPERIMENTS), AND THE SPATIAL PROPAGATION PATTERNS OF FIBRIL FORMATION (COMPARED TO AFOREMENTIONED MICROFLUIDIC EXPERIMENTS). ANALYSIS OF THE VALIDATED MODELS WILL THEN BE USED TO PROPOSE POTENTIAL MECHANISMS FOR PRIMARY NUCLEATION, THE MODULATION OF WHICH IS ACTIVELY BEING EXPLORED FOR THE DEVELOPMENT OF PREVENTATIVE TREATMENTS FOR AMYLOID DISEASES. THE PROPOSED WORK WILL REQUIRE AN INNOVATION TO THE NETWORK HAMILTONIAN METHODOLOGY (FIRST INTRODUCED BY THE PI AND OTHERS), IN THAT IT WILL BE THE FIRST TO INCLUDE EXPLICIT SPATIAL DEGREES OF FREEDOM. THIS DEVELOPMENT WILL FACILITATE THE COMPARISON OF NETWORK HAMILTONIAN MODELS TO EXPERIMENTAL RESULTS AND ENHANCE THE PREDICTIVE POWER OF THE SIMULATIONS, FOR BOTH THE PRESENT WORK AND FUTURE STUDIES IN MOLECULAR SELF-ASSEMBLY.

ANALYZING CAREGIVER LINGUISTIC INPUT DURING A REMOTE DIALOGIC BOOK-SHARING INTERVENTIONS FOR TODDLERS WITH CLEFTS. - PROJECT SUMMARY CLEFT PALATE WITH OR WITHOUT CLEFT LIP (CP±L) IS AMONG THE MOST COMMON CONGENITAL CONDITIONS, AFFECTING APPROXIMATELY 1 IN 450 INFANTS WORLDWIDE AND 1 IN 1050 INFANTS IN THE UNITED STATES. WHILE MOST CHILDREN UNDERGO EARLY SURGICAL REPAIR, MANY CONTINUE TO EXPERIENCE SIGNIFICANT SPEECH AND LANGUAGE DELAYS THAT IMPACT SOCIAL AND ACADEMIC DEVELOPMENT. RECENT RESEARCH HAS HIGHLIGHTED THE POTENTIAL OF PARENT/CAREGIVER-FOCUSED INTERVENTIONS IN SUPPORTING LANGUAGE DEVELOPMENT IN CHILDREN WITH CP±L, BUT THE SPECIFIC MECHANISMS UNDERLYING THESE INTERVENTIONS ARE NOT YET FULLY UNDERSTOOD. THIS GOAL OF THIS STUDY IS TO EXAMINE THE MECHANISTIC ROLE OF PARENT/CAREGIVER'S SPEECH INPUTS IN SUPPORTING LANGUAGE DEVELOPMENT IN TODDLERS WITH CP±L. THIS STUDY FILLS CRITICAL GAPS BY TRANSCRIBING, CODING, AND ANALYZING OBSERVATIONAL DATA FROM A REMOTE DIALOGIC BOOK-SHARING (DBS) INTERVENTION FOR TODDLERS WITH CP±L (RANDOMIZED CONTROLLED TRIAL OR RCT OF THE INTERVENTION, BOOK SHARING FOR TODDLERS WITH CLEFTS – BOOST; NCT06338319). UNLIKE PRIOR WORK RELYING ON AUDIO-ONLY DATA, THIS RESEARCH UNIQUELY INCLUDES GESTURAL COMMUNICATION, SUCH AS DEICTIC GESTURES, WHICH MAY ACT AS COMPENSATORY STRATEGIES IN CHILDREN WITH IMPAIRED SPEECH AND ARE LINKED TO VOCABULARY DEVELOPMENT. THROUGH LANGUAGE SAMPLE ANALYSIS OF VIDEO-RECORDED PARENT-CHILD BOOK-SHARING INTERACTIONS COLLECTED AT FIVE TIMEPOINTS, WE WILL EXAMINE HOW PARENT/CAREGIVER LANGUAGE QUANTITY (E.G., UTTERANCE FREQUENCY, SPEECH RATE, PAUSE TIME) AND RESPONSIVENESS (E.G., CONTINGENT RESPONSES, CONVERSATIONAL TURNS, DEICTIC GESTURES, PERSONALIZATION, CATEGORIZATION, AND TEMPORAL RESPONSES) CHANGE OVER THE COURSE OF THE INTERVENTION. WE WILL ALSO EVALUATE HOW THESE CHANGES RELATE TO EXPRESSIVE AND RECEPTIVE LANGUAGE IMPROVEMENTS IN CHILDREN WITH CP±L. CLINICALLY, THIS WORK WILL CLARIFY CAREGIVER-MEDIATED MECHANISMS TO ENHANCE TARGETED INTERVENTIONS FOR CHILDREN WITH CP±L AND OTHER LANGUAGE DELAYS, IMPROVING LONG-TERM DEVELOPMENTAL OUTCOMES. IN LINE WITH THE R15'S DUAL GOALS, THE PROJECT WILL BUILD RESEARCH INFRASTRUCTURE BY TRAINING UNDERGRADUATE AND GRADUATE STUDENTS IN DEVELOPMENTAL RESEARCH METHODS, INCLUDING TRANSCRIPTION, CODING, AND DATA ANALYSIS. THIS TRAINING WILL PROVIDE HANDS-ON INTERDISCIPLINARY EXPERIENCE, STRENGTHEN RESEARCH CAPACITY AT A PRIMARILY UNDERGRADUATE INSTITUTION, AND FOSTER A COLLABORATIVE ENVIRONMENT THAT INTEGRATES CLINICAL AND DEVELOPMENTAL SCIENCE. BY MOVING BEYOND TRADITIONAL SPEECH METRICS TO INCORPORATE GESTURE AND MULTIDIMENSIONAL RESPONSIVENESS, THIS STUDY ADVANCES UNDERSTANDING OF PARENT INPUT'S ROLE IN LANGUAGE DEVELOPMENT FOR CHILDREN WITH CP±L AND LAYS A FOUNDATION FOR FUTURE RESEARCH TO REFINE AND EXPAND PARENT-MEDIATED INTERVENTIONS. CHONG R15

ASPIRE (STUDENT SUPPORT SERVICES) - SAN JOSE STATE UNIVERSITY - FY 2025 - 2030

SUPPORT FOR THE AMERICAN CHEMICAL SOCIETY'S SUMMER SCHOOLS IN NULCEAR AND RADIOCHEMISTRY

A RADIO FREQUENCY PATH CHARACTERIZATION SYSTEM FOR RESEARCH ON QUANTIFYING ELECTROMAGNETIC WAVE PROPAGATION THROUGH THE LOWER ATMOSPHERE

CLOSING THE CARBON CYCLE LOOP: QUANTIFYING LAND-TO-SEA CARBON FLUXES

SJSU NATIONAL TRANSPORTATION SECURITY CENTER OF EXCELLENCE

CAREER: CHARACTERIZING GENDERED SOCIALIZATION OF NEWCOMER ENGINEERS TO PROMOTE INCLUSIVE PRACTICES AND RETENTION OF A DIVERSE WORKFORCE

BRC-BIO: ADAPTIVE VARIATION THROUGH SPACE AND TIME IN AMERICAN PIKAS (OCHOTONA PRINCEPS) -ENVIRONMENTS AROUND THE WORLD ARE RAPIDLY CHANGING. AS A RESULT, MANY ANIMALS MUST EITHER ALTER THEIR BEHAVIORS OR BIOLOGY TO ADJUST, MOVE TO A MORE SUITABLE AREA, OR RISK GOING EXTINCT. CHARACTERIZING HOW ANIMALS CHANGED IN THE PAST IS CRUCIAL TO UNDERSTANDING RISKS THEY FACE IN THE PRESENT. A ?SPACE-FOR-TIME? APPROACH ALLOWS FOR INVESTIGATION OF HOW POPULATIONS IN DISSIMILAR ENVIRONMENTS DIFFER IN THEIR BIOLOGY. THIS THEN ALLOWS RESEARCHERS TO INFER HOW THEY MIGHT RESPOND TO FUTURE ENVIRONMENTAL CHANGES. FOR INSTANCE, YOSEMITE NATIONAL PARK IS AT HIGH ELEVATION AND GETS A LOT OF SNOW COMPARED TO THE LOW-LYING MOUNTAIN RANGES OF NEVADA, WHICH ARE RELATIVELY HOT AND DRY. AS YOSEMITE GETS WARMER AND DRIER, ANIMALS IN THAT AREA MAY START LOOKING AND BEHAVING MORE LIKE THE POPULATIONS FOUND IN NEVADA. IN CONTRAST, A ?TEMPORAL? APPROACH INVOLVES ANALYZING DATA FROM ANIMALS FOUND IN THE SAME LOCATION BUT SEPARATED IN TIME BY A CENTURY OR MORE. BY USING NATURAL HISTORY MUSEUM COLLECTIONS, THIS PROJECT WILL EMPLOY BOTH A SPACE-FOR-TIME AND A TEMPORAL APPROACH WITH AMERICAN PIKAS. PIKAS ARE SMALL, TEMPERATURE-SENSITIVE, RABBIT-LIKE CREATURES THAT LIVE IN ROCKY AREAS. THE WORK AIMS TO BETTER UNDERSTAND HOW THESE POPULATIONS HAVE RESPONDED TO PAST CHANGES WITH THE GOAL OF BETTER PREDICTING THEIR RESPONSE TO CURRENT AND FUTURE ENVIRONMENTAL CHANGE. IN ADDITION, THIS PROJECT WILL PROVIDE RESEARCH EXPERIENCES TO UNDERGRADUATE AND MASTER?S STUDENTS FROM HISTORICALLY UNDERREPRESENTED BACKGROUNDS. FINALLY, THE RESEARCHERS WILL COLLABORATE WITH LOCAL COMMUNITY COLLEGE PROFESSORS TO DEVELOP MATERIAL FOR BIOLOGY CLASSROOMS. THE PROPOSED RESEARCH APPLIES WHOLE GENOME SEQUENCING AND LANDSCAPE GENOMICS TO ANALYZE MODERN AND HISTORIC MUSEUM SPECIMENS OF AMERICAN PIKAS (OCHOTONA PRINCEPS). IMPORTANTLY, THE HISTORIC SPECIMENS WERE COLLECTED PRIOR TO THE ONSET OF CURRENT, RAPID CLIMATE CHANGE. SPECIFICALLY, THIS RESEARCH WILL IDENTIFY ADAPTIVE GENETIC VARIATION ALONG SPATIAL AND TEMPORAL ENVIRONMENTAL GRADIENTS. IT WILL EXAMINE ASSOCIATED PHYSIOLOGICAL PATHWAYS AND INVESTIGATE WHETHER POPULATIONS FROM DIFFERENT GENETIC LINEAGES HAVE EXPERIENCED PARALLEL EVOLUTION FOR THESE TRAITS. FINALLY, THE WORK WILL DEVELOP A PANEL OF NEUTRAL AND FUNCTIONAL GENETIC MARKERS TO NONINVASIVELY SURVEY AND MONITOR POPULATIONS ACROSS THE SPECIES? RANGE. USING BOTH A SPACE-FOR-TIME SUBSTITUTION AND A TEMPORAL FRAMEWORK ACROSS A BROAD GEOGRAPHIC AREA ALLOWS FOR MORE ROBUST INFERENCE ON THE ENVIRONMENTAL DRIVERS OF LOCAL ADAPTATION. FURTHERMORE, MAKING SPATIAL AND TEMPORAL COMPARISONS AMONG PAIRS OF POPULATIONS IN DIVERGENT GENETIC LINEAGES ENABLES ANALYSIS OF PARALLEL EVOLUTION. THIS RESEARCH WILL BE AN IMPORTANT STEP IN QUANTIFYING THE EVOLUTIONARY RESPONSE OF A TEMPERATURE-SENSITIVE SPECIES TO RAPID CLIMATE CHANGE. LIKEWISE, IT WILL SIGNIFICANTLY IMPROVE OUR ABILITY TO PREDICT FUTURE RESPONSE AND VULNERABILITY OF AMERICAN PIKAS AND SPECIES WITH SIMILAR LIMITATIONS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

SCIENCE SUPPORT FOR THE KEPLER MISSIONPROPOSAL TO CONTINUE WORK OF DR. NATALIE BATALHA PROFESSOR

CAREER: UNDERSTANDING AND MODELING OF CRYOGENIC SEMICONDUCTOR DEVICE PHYSICS DOWN TO 4.2K

HEALTHY DEVELOPMENT COMMUNITY CLINIC: WELLNESS FOR CHILDREN, YOUTH, & FAMILIES - POPULATION THE HEALTHY DEVELOPMENT COMMUNITY CLINIC (HDCC) SERVES CHILDREN, YOUTH, AND FAMILIES IN SOUTH AND EAST SAN JOSE, CALIFORNIA. ACCORDING TO THE U.S. CENSUS BUREAU (2021), RESIDENTS OF THE CATCHMENT AREA PRIMARILY IDENTIFY AS 39% ASIAN, 25% LATINX, 3% BLACK OR AFRICAN AMERICAN, AND 4% WITH MULTIPLE ETHNORACIAL IDENTITIES. IN THE CITY OF SAN JOSE, 20% OF FAMILIES LIVE BELOW THE FEDERAL POVERTY LINE (FPL) INCLUDING 31% OF SAN JOSE CHILDREN. IN SOUTH SAN JOSE, 26% OF FAMILIES (AND 33% OF CHILDREN) RESIDE IN HOUSEHOLDS AT 185% OR MORE BELOW THE FPL (SANTA CLARA COUNTY PUBLIC HEALTH DEPARTMENT, 2018). ONE-QUARTER OF HOUSEHOLDS HAVE CHILDREN (0-17 YEARS; SANTA CLARA COUNTY PUBLIC HEALTH DEPARTMENT, 2018). FURTHERMORE, 39.7% OF SAN JOSE RESIDENTS ARE BORN OUTSIDE THE UNITED STATES (U.S. CENSUS, 2021), AND 56% OF HOUSEHOLDS REPORT SPEAKING A HOME LANGUAGE OTHER THAN ENGLISH (SANTA CLARA COUNTY PUBLIC HEALTH DEPARTMENT, 2018). COLLECTIVELY, THESE NUMBERS HIGHLIGHT THE MULTIPLE COMMUNITIES WHO MAY EXPERIENCE LANGUAGE, CULTURAL, AND SYSTEMIC BARRIERS TO CARE. SERVICES THE PURPOSE OF THE HEALTHY DEVELOPMENT COMMUNITY CLINIC (HDCC) IS TO PROMOTE EQUITY THROUGH HOLISTIC WELLNESS FOR CHILDREN, YOUTH, AND FAMILIES. THROUGH PRIMARY PREVENTION AND COMMUNITY OUTREACH AND EDUCATION, THE HDCC BUILDS ON INDIVIDUAL, FAMILY, AND COMMUNITY STRENGTHS; CONNECTS FAMILIES WITH EXISTING RESOURCES; AND PROVIDES CULTURALLY- AND LINGUISTICALLY-RESPONSIVE, TRAUMA-INFORMED SERVICES TO MEET THE WIDE-RANGING NEEDS OF CHILDREN, YOUTH, AND FAMILIES. THE HDCC USES AN INTERDISCIPLINARY, TEAM-BASED APPROACH TO LEAD SERVICES THROUGH SCREENINGS, SHORT-TERM INTERVENTIONS, OUTREACH AND EDUCATION, AND TARGETED REFERRALS. SERVICES ADDRESS MENTAL HEALTH, SPEECH AND LANGUAGE, ACADEMIC AND SOCIAL SUCCESS, AND PARENT/FAMILY EDUCATION. EXAMPLES OF SERVICES INCLUDE MENTAL HEALTH, DEVELOPMENTAL, ORAL, HEARING, AND SPEECH AND LANGUAGE SCREENINGS; BRIEF PSYCHOTHERAPY, PSYCHOSOCIAL EDUCATIONAL GROUPS (E.G., COPING SKILLS TO MANAGE ANXIETY, SOCIAL SKILLS FOR HEALTHY RELATIONSHIPS), PARENT AND FAMILY PSYCHOEDUCATION; COMMUNITY WELLNESS EVENTS, AND REFERRALS AND RECOMMENDATIONS FOR COMMUNITY SERVICES. SERVICES ARE PROVIDED BY STUDENT CLINICIANS AND SUPERVISED BY SAN JOSE STATE UNIVERSITY FACULTY AND LICENSED PROVIDERS; THUS, IN ADDITION TO SERVING THE COMMUNITY, THE HDCC IS ALSO TRAINING THE NEXT GENERATION OF MENTAL HEALTH AND HEALTH PROVIDERS. COORDINATION THE HDCC IS COMMITTED TO COORDINATED EFFORTS WITH STATE AND LOCAL HEALTH ORGANIZATIONS TO COLLABORATIVELY ADDRESS HEALTH EQUITY AND COORDINATE CARE. EXTENSIVE AND ONGOING CONVERSATIONS REGARDING FORMAL PROCESSES TO MORE EFFECTIVELY COORDINATE CARE CONTINUE TO EVOLVE. LOCAL AGENCIES SEEKING TO COLLABORATE WITH THE HDCC INCLUDE LOCAL COUNTY COMMUNITY HEALTH ORGANIZATIONS, NON-PROFIT ORGANIZATIONS FOCUSED ON CHILD HEALTH SCREENINGS AND PARENT SUPPORT, COUNTY HEALTH AND EDUCATION LEADERS, AND MOBILE HEALTH SERVICES WHO ARE ABLE TO BRING BRIEF SERVICES INTO THE COMMUNITY.

SPECIAL EDUCATION PRE-SERVICE TRAINING IMPROVEMENT GRANTS

ESTAURIN WETLAND AND NEARSHORE ECOLOGY STUDY PACIFIC FLYWAY

NEW COOP - SJSU

HEART RATE LOGGING IN DEEP DIVING TOOTHED WHALES: A NEW TOOL FOR ASSESSING RESPONSES TO DISTURBANCE

SATC-EDU: IMPROVING COMPUTER FORENSIC CURRICULA THROUGH HANDS-ON HARDWARE AND SOFTWARE TRAINING AND PRACTICAL EXPERIENCE PROCESSING EVIDENCE FROM ACTIVE CRIMINAL CASES -SOCIETY?S RELIANCE ON TECHNOLOGY AND DIGITAL SPACES HAS LED TO A RAPID GROWTH IN CYBER-BASED CRIMINAL ACTIVITIES THAT THREATEN NATIONAL SECURITY. THIS GENERATED A CRITICAL NEED FOR DEVELOPING EDUCATIONAL PRACTICES THAT PREPARE THE CURRENT AND FUTURE WORKFORCE TO INVESTIGATE CYBER THREATS AND PROCESS DIGITAL EVIDENCE. STRATEGIES TO ACHIEVE EFFECTIVE BALANCE OF THEORETICAL AND PRACTICAL EDUCATION ARE YET TO BE FULLY DETERMINED. TO ADDRESS THE NEED FOR EFFECTIVE AND BALANCED EDUCATIONAL PRACTICES, THIS PROJECT WILL INTRODUCE ACTIVE-LEARNING PEDAGOGY INTO AN EXISTING COMPUTER FORENSICS CURRICULUM. ITS EFFECT WILL THEN BE MEASURED BASED ON STUDENT SUCCESS AND DEVELOPMENT OF INDUSTRY-RELEVANT SKILLS. MEASUREMENT WILL BE ACCOMPLISHED IN THREE WAYS. FIRST, THROUGH EVALUATING THE APPROPRIATE BALANCE, AND ORDERING, OF FORENSIC, COMPUTER SCIENCE, AND CRIMINAL JUSTICE COURSES NEEDED TO DEVELOP A STRONG THEORETICAL UNDERSTANDING. SECOND, THROUGH INTRODUCING CLASSROOM TRAINING WITH HARDWARE AND SOFTWARE CURRENTLY USED WITHIN THE DISCIPLINE, TO DEVELOP STRONG PRACTICAL SKILLS FOR ENTRY-LEVEL POSITIONS. THIRD, THROUGH PROVIDING HANDS-ON INTERNSHIPS THAT REQUIRE PROCESSING OF DIGITAL EVIDENCE FROM ACTIVE CRIMINAL INVESTIGATIONS TO PROVIDE WORK EXPERIENCE AND JOB TRAINING. AS SAN JOSE STATE UNIVERSITY IS BOTH A HISPANIC-SERVING INSTITUTION AND AN ASIAN AMERICAN AND PACIFIC ISLANDER-SERVING INSTITUTION, A FOCUS WILL BE PLACED ON HOW THESE CURRICULAR CHANGES CONTRIBUTE TO THE DIVERSIFICATION OF THE CYBERSECURITY WORKFORCE. COMPUTER FORENSIC (CF) INVESTIGATORS REQUIRE A UNIQUE EDUCATION BALANCING FORENSICS, COMPUTER SCIENCE, AND CRIMINAL JUSTICE. THIS INCLUDES NOT ONLY A THEORETICAL FOUNDATION, BUT ALSO PRACTICAL EXPERIENCE PROCESSING DIGITAL EVIDENCE. TO MEET THESE NEEDS, EDUCATION WILL INCORPORATE TRAINING ON THE TECHNOLOGIES AND CURRENT BEST PRACTICES USED WITHIN THE DISCIPLINE THROUGH HANDS-ON EXPERIENCES WITH THE LATEST TRENDS IN SOURCES (DEVICES) OF DIGITAL EVIDENCE. EXISTING LEARNING ENVIRONMENTS WILL BE MODIFIED IN THREE DIFFERENT WAYS AND EVALUATED TO MEASURE THE IMPACTS ON STUDENT SUCCESS AND WORKPLACE PREPAREDNESS, ESPECIALLY AMONG UNDERREPRESENTED GROUPS. FIRST, BY IDENTIFYING HOW STUDENTS? NAVIGATIONAL PATH (E.G., ORDER OF COURSES, PRE-EXISTING KNOWLEDGE) WITHIN THE INTERDISCIPLINARY COURSEWORK IMPACTS THE SUCCESSFUL COMPLETION OF THE PROGRAM, AND HOW MODIFICATIONS TO THESE PATHWAYS CAN INCREASE STUDENT SUCCESS. SECOND, BY INTRODUCING ACTIVE-LEARNING PEDAGOGY INTO THE CLASSROOM AND TRAINING ON HARDWARE AND SOFTWARE CURRENTLY USED BY CF PRACTITIONERS. THIRD, BY DEVELOPING A LABORATORY INFRASTRUCTURE FOR STUDENTS TO COMPLETE INTERNSHIPS WHERE THEY CAN CONDUCT DIGITAL EVIDENCE INVESTIGATIONS ON ACTIVE CRIMINAL CASES. THE EFFECTIVENESS OF THESE MODIFICATIONS WILL BE MEASURED THROUGH INTERVIEWS WITH CF PRACTITIONERS ON THE SKILL SETS REQUIRED FOR THE DISCIPLINE, SURVEYS OF STUDENT NAVIGATION AND ACTIVITIES, SURVEYS OF LABORATORY INTERN EXPERIENCES, AND SURVEYS OF GRADUATES' ABILITIES TO SUCCESSFULLY TRANSITION INTO CAREERS WITHIN THE DISCIPLINE. RESULTS WILL BE DISSEMINATED THROUGH ONLINE OPEN-SOURCE EDUCATIONAL MATERIALS, PRESENTATIONS TO CRIMINAL JUSTICE AGENCIES AND HIGHER EDUCATION INSTITUTIONS, AND PEER-REVIEWED PUBLICATIONS. DISSEMINATION OF RESULTS WILL AID THE DEVELOPMENT OF EFFECTIVE CF CURRICULUM AT OTHER INSTITUTIONS. THIS PROJECT IS SUPPORTED BY THE SECURE AND TRUSTWORTHY CYBERSPACE (SATC) PROGRAM, WHICH FUNDS PROPOSALS THAT ADDRESS CYBERSECURITY AND PRIVACY, AND IN THIS CASE SPECIFICALLY CYBERSECURITY EDUCATION. THE SATC PROGRAM ALIGNS WITH THE FEDERAL CYBERSECURITY RESEARCH AND DEVELOPMENT STRATEGIC PLAN AND THE NATIONAL PRIVACY RESEARCH STRATEGY TO PROTECT AND PRESERVE THE GROWING SOCIAL AND ECONOMIC BENEFITS OF CYBER SYSTEMS WHILE ENSURING SECURITY AND PRIVACY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

IDENTIFICATION CHARACTERIZATION AND PRIORITIZATION OF HUMAN PERFORMANCE ISSUES AND RESEARCH IN THE

COLLABORATIVE RESEARCH: A TECHNOLOGY PATHWAY PROGRAM IN DATA TECHNOLOGY AND APPLICATIONS

SUISUN MARSH WATERFOWL SCIENCE INVESTIGATIONS: DATA SYNTHESIS AND MANUSCRIPT PREPARATION

THE PROPOSED RESEARCH FOR NGATS-ATM AIRSPACE PROJECT SUBTASK 9 IS TO WILL IDENTIFY AND PRIORITIZE LE

COLLABORATIVE RESEARCH: BENTHIC EXHANGE EVENTS AND NEAR-BOUNDARY MIXING ON THE CONTINENTAL SHELF

PROJECT INCLUDE: INTEGRATING NEURODIVERSITY AND CULTURAL-LINGUISTIC UNDERSTANDING AND DIFFERENCES IN EDUCATION

OCEANOGRAPHIC TECHNICAL SERVICES, R/V POINT SUR, 2012 ? 2016

COLLABORATIVE RESEARCH: ICE SUPERSATURATION OVER THE SOUTHERN OCEAN AND ANTARCTICA, AND ITS ROLE IN CLIMATE

COLLABORATIVE RESEARCH: A BRIDGE TO PHYSICS AND ASTRONOMY DOCTORATES FOR STUDENTS WITH FINANCIAL NEED

COLLABORATIVE RESEARCH: DEVELOPING AUTOMATED NUTRIENT AND TRACE METAL METHODOLOGY USING PROGRAMMABLE FLOW INJECTION

REU SITE: RESEARCH BY UNDERGRADUATES USING MOLOCULAR BIOLOGY APPLICATIONS (RUMBA)

COLLABORATIVE RESEARCH: SUNDOWNER WINDS EXPERIMENT (SWEX) IN SANTA BARBARA, CALIFORNIA

RUI: BIOCHEMICAL ANALYSIS OF MASTERMIND DEPENDENT ACTIVATION OF NOTCH TARGET GENES

MRI: ACQUISITION OF A HIGH-SPEED PARTICLE IMAGE VELOCIMETRY INSTRUMENT

COLLABORATIVE RESEARCH: MRI-R2--ACQUISITION OF A MOBILE ATMOSPHERIC PROFILING SYSTEM FOR MULTI-CAMPUS RESEARCH AND EDUCATION (CSU-MAPS)

A REGIONAL COMPARIOSN OF UPWELLING AND COASTAL LAND USE PATTERNS ON THE DEVELOPMENT OF HAB HOTSPOTS ALONG THE CALIFORNIA COAST

INSTITUTE FOR COLLABORATIVE RESPONSE TO VICTIMS OF DOMESTIC VIOLENCE

COLLABORATIVE RESPONSE TO VICTIMS OF DOMESTIC VIOLENCE

REGULATION OF MAMMARY GLAND DEVELOPMENT BY SIRTUIN 4 - PROJECT SUMMARY THE MITOCHONDRIAL ENZYME SIRTUIN 4 (SIRT4) IS DOWNREGULATED IN BREAST CANCER TISSUE, BUT THE REASON FOR THIS IS NOT CLEAR. IN ORDER TO ELUCIDATE THIS, WE FIRST SOUGHT TO DETERMINE THE ROLE OF SIRT4 IN NORMAL MAMMARY TISSUE. WE HAVE DISCOVERED THAT SIRT4 IS CRITICAL FOR ENSURING NORMAL MAMMARY DEVELOPMENT. IN MICE WITH A TOTAL LACK OF SIRT4 (SIRT4KO MICE), MAMMARY GLANDS DO NOT FULLY DEVELOP DURING PUBERTY. AS A RESULT, THEY DO NOT PRODUCE ENOUGH MATERNAL BREAST MILK DURING PREGNANCY AND NEARLY 100% OF THEIR YOUNG PERISH TWO DAYS AFTER BIRTH. WE NOW SEEK TO UNCOVER THE MECHANISM BY WHICH SIRT4 INFLUENCES MAMMARY GLAND DEVELOPMENT. FIRST, WE SEEK TO INVESTIGATE THE POTENTIAL ROLE OF THE OVARIAN HORMONES 17SS-ESTRADIOL (E2) AND PROGESTERONE (P4) IN MEDIATING THE EFFECTS OF SIRT4 ON MAMMARY DEVELOPMENT (AIM 1). THESE TWO HORMONES ARE ESSENTIAL FOR INITIATING GROWTH OF MILK-PRODUCING MAMMARY DUCTS DURING PUBERTY AND PREGNANCY AND THE MAMMARY DEFECTS SEEN IN SIRT4KO MICE ARE REMINISCENT OF THE DEFECTS SEEN IN MICE WITH DISRUPTED E2 OR P4 SIGNALING. FURTHERMORE, SINCE SIRT4 IS FOUND IN MITOCHONDRIA AND IS KNOWN TO HAVE MANY METABOLIC EFFECTS, WE SEEK TO INVESTIGATE THE POSSIBILITY THAT SIRT4 REGULATES MAMMARY DEVELOPMENT BY CONTROLLING NUTRIENT METABOLISM IN MAMMARY GLANDS (AIM 2). ALTERED METABOLIC STATES IN BOTH MICE AND HUMANS HAVE BEEN SHOWN TO INHIBIT MAMMARY DEVELOPMENT. FOR EXAMPLE, BOTH UNDERWEIGHT AND OVERWEIGHT MICE HAVE IMPAIRED MAMMARY DEVELOPMENT THAT CAN RESULT IN INSUFFICIENT LACTATION. THUS, WE SEEK TO DETERMINE WHETHER THE KNOWN EFFECTS OF SIRT4 ON NUTRIENT METABOLISM MAY CONTRIBUTE TO HOW SIRT4 REGULATES MAMMARY DEVELOPMENT. OVERALL, OUR PROPOSED STUDIES WILL REVEAL A NEW ROLE FOR SIRT4 IN REGULATING MAMMARY DEVELOPMENT. ULTIMATELY, BY INVESTIGATING HOW SIRT4 INFLUENCES NORMAL MAMMARY PHYSIOLOGY, WE MAY BETTER UNDERSTAND WHY SIRT4 EXPRESSION LEVELS ARE DOWNREGULATED IN BREAST CANCER TISSUE AND WHETHER THIS CONTRIBUTES TO DISEASE PROGRESSION.

INCREASED INTRACELLULAR PH PROMOTES CANCER CELL BEHAVIORS - PROJECT SUMMARY CONSTITUTIVELY INCREASED INTRACELLULAR PH (PHI) IS COMMON TO MOST CANCERS REGARDLESS OF TISSUE ORIGIN OR GENETIC BACKGROUND. INCREASED PHI IS SUFFICIENT TO INDUCE ONCOGENIC PHENOTYPES, INCLUDING DYSREGULATED TISSUE GROWTH, DYSPLASIA, AND INVASIVE CELL MIGRATION. PH-REGULATED CELL BEHAVIORS ARE MEDIATED BY CHANGES IN THE PROTONATION STATE OF PH SENSITIVE PROTEINS, TERMED PH SENSORS. AT THE MOLECULAR LEVEL, CHANGES IN PHI CAN ALTER THE PROTONATION STATE OF AMINO ACID RESIDUES WITH PKA VALUES NEAR NEUTRAL, WHICH CAN MARKEDLY AFFECT PROTEIN CONFORMATION AND FUNCTION. BY CHANGING THE PROTONATION OF MULTIPLE PROTEINS IN UNISON, PHI DYNAMICS CAN COORDINATE COMPLEX CELL PROCESSES. ALTHOUGH UNDERSTUDIED, EMERGING EVIDENCE SUGGESTS THAT INCREASED PHI CONTRIBUTES TO TUMORIGENESIS. IN THIS PROPOSAL, WE WILL EXPLORE HOW INCREASED PHI REGULATES THE PROTO-ONCOGENE MYC, AND DETERMINE HOW AUTOPHAGIC CELL DEATH IS ENHANCED UNDER THESE CONDITIONS. AIM 1 WILL EXPLORE PH DEPENDENT REGULATION OF MYC. OVER-EXPRESSION OF MYC RESCUES THE SIZE AND PATTERNING ERRORS INDUCED BY INCREASED PHI, SUGGESTING DECREASED MYC ABUNDANCE OR ACTIVITY. WE WILL IDENTIFY THE DOMAINS IN MYC PROTEIN THAT MEDIATE PH-SENSITIVITY, AND THE EFFECTS OF INCREASED PHI ON MYC FUNCTION. WE WILL EXPLORE TRANSCRIPTIONAL EFFECTS OF INCREASED PHI TO DETERMINE AFFECTED PATHWAYS AND MOLECULES. AIM 2 WILL DETERMINE REGULATION OF AUTOPHAGY AT INCREASED PHI. WE WILL TEST IF MYC DIRECTLY REGULATES AUTOPHAGY IN DROSOPHILA TISSUES USING ESTABLISHED MOLECULAR MARKERS. WE WILL DEVELOP OUR CLONAL MAMMALIAN CELL SYSTEM TO TEST WHETHER INCREASED AUTOPHAGY AT INCREASED PHI IS CONSERVED, AND IDENTIFY AFFECTED PROTEINS. FINALLY, WE WILL MEASURE AUTOPHAGIC FLUX IN TUMORS WITH DYSREGULATED PHI TO TEST THE HYPOTHESIS THAT INCREASED PHI PROMOTES TUMOR GROWTH VIA RECYCLING OF CELLULAR BUILDING BLOCKS GENERATED BY AUTOPHAGY. USING OUR ESTABLISHED METHODS IN THE GENETIC MODEL ORGANISM DROSOPHILA AND IN CLONAL MAMMALIAN CELLS, WE BRIDGE SCALES FROM TISSUE-LEVEL PHENOTYPIC ANALYSES TO INDIVIDUAL PH- SENSITIVE PROTEINS THAT REGULATE CANCER CELL BEHAVIORS. SIGNIFICANT OUTCOMES FROM OUR STUDIES INCLUDE NEW INSIGHTS ON HOW PH-REGULATED CELLULAR BEHAVIORS ENABLE TUMORIGENESIS. OUR STRENGTHS AND EXPERIENCE LINKING TISSUE-LEVEL PHENOTYPES TO INDIVIDUAL PH-SENSITIVE MOLECULES PERMIT UNIQUE INSIGHTS IN THIS UNDER-STUDIED AREA OF BIOLOGY. INSIGHTS INTO THE MOLECULAR MECHANISMS OF PH- SENSITIVE PROTEINS MAY INFORM THERAPEUTIC APPROACHES TO LIMIT TUMORIGENESIS.

MOLECULAR MEDIATORS OF MUSCLE SPINDLE MECHANOSENSATION - PROJECT SUMMARY: MOLECULAR MEDIATORS OF MUSCLE SPINDLE MECHANOSENSATION. MANY CONDITIONS, INCLUDING AGING, CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY, AND NEUROMUSCULAR DISEASES, NEGATIVELY IMPACT THE FUNCTION OF MUSCLE PROPRIOCEPTORS. THE GROUP IA AND II MUSCLE SPINDLE AFFERENTS ARE SLOWLY-ADAPTING MECHANORECEPTORS AND PROVIDE THE PRIMARY SENSORY INFORMATION FOR PROPRIOCEPTION AND COMPRISE THE SENSORY ARM OF THE MUSCLE STRETCH REFLEX. THE EXACT MOLECULAR MECHANISM USED TO TRANSLATE MUSCLE STRETCH INTO ACTION POTENTIALS IN THESE NEURONS IS ONLY INCOMPLETELY UNDERSTOOD. HOWEVER, THE MECHANICALLY GATED ION CHANNEL PIEZO2 IS KNOWN TO BE NECESSARY FOR NORMAL STRETCH SENSITIVITY AND MULTIPLE GENETIC DISEASES THAT INCREASE OR DECREASE PIEZO2 CHANNEL FUNCTION ARE KNOWN TO IMPAIR PROPRIOCEPTION AND MOTOR BEHAVIORS. THE VOLTAGE GATED SODIUM CHANNEL NAV1.1 AND VESICLE-RELEASED GLUTAMATE ARE ALSO KNOWN TO BE NECESSARY FOR MAINTAINED EXCITABILITY DURING STATIC STRETCH. THE OVERARCHING GOAL OF THIS PROPOSAL IS TO UNDERSTAND HOW THE DEVELOPMENTAL TIMING OF DYSFUNCTION IN THOSE PROTEINS ALTERS MUSCLE SPINDLE AFFERENT MECHANOSENSATION. WE WILL DETERMINE HOW A MOUSE MODEL WITH A GAIN OF FUNCTION MUTATION TO PIEZO2 WHICH LEADS TO DISTAL ARTHROGRYPOSIS TYPE 5 ALTERS MECHANOSENSATION IN THE MUSCLE SPINDLE AFFERENTS WHEN IT IS EXPRESSED THROUGHOUT DEVELOPMENT OR ONLY AFTER THE MUSCLE SPINDLE IS DEVELOPED (AIM 1). SIMILARLY, WE WILL DETERMINE WHETHER LOSS OF PIEZO2 ONCE THE MUSCLE SPINDLE DEVELOPS ELIMINATES STRETCH SENSITIVE FIRING AS IT DOES FOLLOWING CONSTITUTIVE LOSS. WE WILL ALSO USE A MODEL OF ANGELMAN SYNDROME THAT DECREASES PIEZO2 CHANNEL ACTIVITY TO DETERMINE HOW MECHANOSENSATION IS IMPAIRED UNDER A LESS COMPLETE DECREASE IN PIEZO2 FUNCTION (AIM 2). FINALLY, WE WILL DETERMINE WHETHER LOSS OF NAV1.1 AFTER THE MUSCLE SPINDLE HAS DEVELOPED LEADS TO SIMILAR INCONSISTENT STATIC PHASE FIRING AS OBSERVED FOLLOWING CONSTITUTIVE LOSS AND WHETHER NAV1.1 AND/OR VESICLE-RELEASED GLUTAMATE ARE LESS IMPORTANT FOR MEDIATING THE MORE RAPIDLY-ADAPTING STRETCH RESPONSES SEEN BEFORE THE MUSCLE SPINDLE MATURES (AIM 3). THESE RESULTS WILL INCREASE UNDERSTANDING OF HOW ALTERATION IN THE FUNCTION OF KEY COMPONENTS OF THE MUSCLE SPINDLE AFFERENT MECHANOTRANSDUCTION MACHINERY AFFECT FUNCTION DURING GENETIC DISORDERS OR OTHER LATER-ONSET DISEASE STATES THAT TARGET THESE MOLECULAR MEDIATORS.

MECHANISM OF TOXIN MEDIATED DAMAGE TO THE LUNG EPITHELIUM DURING S. PNEUMONIAE INFECTION - PROJECT SUMMARY STREPTOCOCCUS PNEUMONIAE CAUSES OVER 150,000 HOSPITALIZATIONS ANNUALLY IN THE U.S., WITH A MORTALITY RATE OF 5- 7%, MAKING THE DISEASE BOTH A SIGNIFICANT HEALTH AND FINANCIAL BURDEN. A KEY VIRULENCE FACTOR DURING S. PNEUMONIAE INFECTION IS PNEUMOLYSIN (PLY), A CHOLESTEROL DEPENDENT CYTOLYSIN (CDC) THAT CAUSES ION FLUX IN HOST CELLS THROUGH ITS ABILITY TO FORM LARGE 400Å PORES IN HOST CELL MEMBRANES. THE GOAL OF THE PROPOSED RESEARCH IS TO ELUCIDATE THE ROLE OF PLY-DEPENDENT ION FLUX IN THE DISRUPTION OF THE LUNG EPITHELIUM. INTERCELLULAR JUNCTIONS (IJS) ARE CRUCIAL FOR MAINTAINING LUNG EPITHELIAL INTEGRITY AND INCLUDE ADHERENS JUNCTIONS AND TIGHT JUNCTIONS. OUR HYPOTHESIS IS THAT PLY- DEPENDENT ION FLUX DISRUPTS ADHERENS JUNCTIONS (AIM 1) AND TIGHT JUNCTIONS (AIM 2) DURING S. PNEUMONIAE INFECTION. WE WILL INVESTIGATE THIS HYPOTHESIS WITH AN AIR-LIQUID-INTERFACE (ALI) CULTURE SYSTEM THAT GENERATES POLARIZED LUNG EPITHELIAL MONOLAYERS. IN AIM 1 WE WILL DETERMINE HOW PLY-DEPENDENT ION FLUX DISRUPTS ADHERENS JUNCTION PROTEINS. TO ASSESS PLY-DEPENDENT ION FLUX REMOVAL OF ADHERENS JUNCTION PROTEINS, WE WILL LOAD CELLS WITH ION SPECIFIC FLUORESCENT INDICATORS, INFECT WITH PLY-PROFICIENT (WT) OR PLY-DEFICIENT (∆PLY) S. PNEUMONIAE STRAINS, AND MEASURE CHANGES IN FLUORESCENCE. WE WILL ALSO PERFORM THESE INFECTIONS WITH ION SPECIFIC CHELATORS TO SHOW CHELATOR EFFICACY IN BLOCKING ION FLUX. TO DETERMINE THE ROLE OF ION FLUX IN ADHERENS JUNCTION DISRUPTION, WE WILL INFECT ALI MONOLAYERS WITH WT OR ∆PLY S. PNEUMONIAE IN THE PRESENCE OR ABSENCE OF ION SPECIFIC CHELATORS, STAIN ADHERENS JUNCTIONS WITH FLUORESCENT ANTIBODIES, IMAGE MONOLAYERS BY CONFOCAL MICROSCOPY, PERFORM IMAGE ANALYSIS, AND USE PRISM FOR STATISTICAL ANALYSIS. FINALLY, WE WILL ASSESS IF ANY ADHERENS JUNCTION PROTEINS ARE CLEAVED AS A RESULT OF PLY- DEPENDENT ION FLUX AND IDENTIFY THE PROTEASE RESPONSIBLE USING CHEMICAL INHIBITORS AND CRISPR-CAS9 GENE-EDITING. ION FLUX CAUSED BY PORE FORMING TOXINS DISRUPTS TIGHT JUNCTIONS AND ADHERENS JUNCTIONS VIA SHARED, BUT DISTINCT PATHWAYS, THUS, TO ACCURATELY UNDERSTAND HOW ION FLUX DISRUPTS TIGHT JUNCTIONS, WE WILL EVALUATE THEM SEPARATELY FROM ADHERENS JUNCTIONS. IN AIM 2 WE WILL ELUCIDATE HOW PLY-DEPENDENT ION FLUX DISRUPTS TIGHT JUNCTION PROTEINS IN AN ANALOGOUS MANNER TO AIM 1. BRIEFLY, WE WILL INFECT MONOLAYERS WITH WT OR ∆PLY S. PNEUMONIAE, STAIN TIGHT JUNCTION PROTEINS, IMAGE THE MONOLAYERS BY CONFOCAL MICROSCOPY, AND PERFORM QUANTITATIVE IMAGE AND STATISTICAL ANALYSIS. IN PARALLEL, WE WILL ASSESS IF ANY TIGHT JUNCTION PROTEINS ARE CLEAVED AS A RESULT OF PLY-DEPENDENT ION FLUX AND IDENTIFY THE PROTEASE RESPONSIBLE USING CHEMICAL INHIBITORS AND CRISPR-CAS9 GENE-EDITING. PLY IS ONE OF 20+ CDCS THAT SHARE 40-80% HOMOLOGY WITH EACH OTHER. TO ASSESS IF ION FLUX IS A CONSERVED MECHANISM FOR CDCS TO DISRUPT TIGHT JUNCTIONS WE WILL ASSESS CDC-DEPENDENT ION FLUX AS DESCRIBED IN AIM 1. WE WILL ALSO TREAT MONOLAYERS WITH CDCS AND ANALYZE TIGHT JUNCTION DISRUPTION AS DESCRIBED IN AIM 2. COLLECTIVELY, THESE EXPERIMENTS WILL ELUCIDATE THE MECHANISM OF HOW PLY DISRUPTS THE LUNG EPITHELIUM, A KEY EVENT FOR S. PNEUMONIAE DISSEMINATION AND A CONSERVED STRATEGY USED BY MANY OTHER RESPIRATORY PATHOGENS.

MICROBIAL AND HOST FACTORS THAT PROMOTE EPITHELIAL DISRUPTION AND S. PNEUMONIAE TRANSIT OUT OF THE LUNG - PROJECT SUMMARY STREPTOCOCCUS PNEUMONIAE CAUSES ~900,000 CASES OF PNEUMOCOCCAL PNEUMONIA ANNUALLY IN THE US, WITH A MORTALITY RATE OF 5-7%, MAKING THIS DISEASE A MAJOR HEALTH AND FINANCIAL BURDEN. S. PNEUMONIAE LUNG INFECTIONS CAN SPREAD TO THE BLOODSTREAM (BACTEREMIA) AND LEAD TO SEVERE PATIENT OUTCOMES. THE GOAL OF THE PROPOSED RESEARCH IS TO ELUCIDATE THE MICROBIAL (AIM 1) AND HOST (AIM 2) FACTORS THAT ENABLE THIS BACTERIUM TO TRANSIT FROM THE LUNG TO THE BLOOD, AN ABILITY THAT IS CRITICAL FOR MANY RESPIRATORY PATHOGENS TO CAUSE DISSEMINATED INFECTION. AN IMPORTANT VIRULENCE FACTOR DURING S. PNEUMONIAE INFECTION IS PNEUMOLYSIN (PLY), A PORE FORMING TOXIN, WHICH HAS BEEN IMPLICATED IN THE DEVELOPMENT OF BACTEREMIA. S. PNEUMONIAE INFECTIONS ARE ALSO CHARACTERIZED BY AN EXCESSIVE IMMUNE RESPONSE MEDIATED PRIMARILY BY WHITE BLOOD CELLS CALLED POLYMORPHONUCLEAR CELLS (PMNS) THAT CAN CAUSE HOST DAMAGE AND RESULT IN LETHAL INFECTION. OUR OVERALL HYPOTHESIS IS THAT PLY AND PMN MIGRATION DISRUPT THE LUNG EPITHELIUM, PROMOTING BACTERIAL TRANSIT FROM THE LUNG INTO THE BLOODSTREAM. WE WILL INVESTIGATE THIS HYPOTHESIS BY USING AN IN VITRO TRANSEPITHELIAL MIGRATION ASSAY, WHICH ALLOWS US TO ASSESS HOW BACTERIA TRANSIT ACROSS THE LUNG EPITHELIUM, ANALOGOUS TO BACTERIAL DISSEMINATION FROM THE LUNGS INTO THE BLOODSTREAM IN VIVO. THIS VERSATILE SYSTEM MODELS DIVERSE MICROENVIRONMENTS, IS EASY TO MAINTAIN, AND INTEGRATES SEAMLESSLY WITH OTHER MOLECULAR BIOLOGY AND MICROBIOLOGY TECHNIQUES. IN AIM 1 WE WILL DETERMINE HOW PLY DISRUPTS INTERCELLULAR JUNCTIONS OF THE LUNG EPITHELIUM AND HOW THAT PROMOTES S. PNEUMONIAE TRANSIT OUT OF THE LUNGS INDEPENDENT OF PMNS. TO ASSESS PLY-MEDIATED REMOVAL OF INTERCELLULAR JUNCTION PROTEINS, WE WILL INFECT POLARIZED LUNG EPITHELIAL MONOLAYERS WITH PLY-PROFICIENT (WT) OR PLY-DEFICIENT ISOGENIC BACTERIAL STRAINS, STAIN INTERCELLULAR JUNCTION PROTEINS WITH FLUORESCENT ANTIBODIES, IMAGE THE MONOLAYERS BY CONFOCAL MICROSCOPY, AND USE IMAGE J AND PRISM SOFTWARE TO PERFORM QUANTITATIVE IMAGE AND STATISTICAL ANALYSIS, RESPECTIVELY. IN PARALLEL, WE WILL QUANTIFY S. PNEUMONIAE TRANSIT ACROSS LUNG EPITHELIAL MONOLAYERS TO CONNECT PLY-MEDIATED DISRUPTIONS OF INTERCELLULAR JUNCTIONS TO CHANGES IN BACTERIAL MIGRATION IN THE ABSENCE OF PMNS. IN AIM 2 WE WILL IDENTIFY HOW PMNS DISRUPT INTERCELLULAR JUNCTIONS OF THE LUNG EPITHELIUM AND HOW THIS PERTURBATION PROMOTES S. PNEUMONIAE TRANSIT OUT OF THE LUNGS. TO EVALUATE PMN-MEDIATED REMOVAL OF INTERCELLULAR JUNCTION PROTEINS, WE WILL INFECT POLARIZED LUNG EPITHELIAL MONOLAYERS WITH WT S. PNEUMONIAE IN THE PRESENCE OR ABSENCE OF PMNS, STAIN INTERCELLULAR JUNCTION PROTEINS WITH FLUORESCENT ANTIBODIES, IMAGE THE MONOLAYERS BY CONFOCAL MICROSCOPY, AND USE IMAGE J AND PRISM SOFTWARE TO PERFORM QUANTITATIVE IMAGE AND STATISTICAL ANALYSIS, RESPECTIVELY. IN PARALLEL WITH THESE EXPERIMENTS, WE WILL MEASURE S. PNEUMONIAE TRANSIT ACROSS THE LUNG EPITHELIAL MONOLAYERS TO CONNECT PMN-MEDIATED MONOLAYER DISRUPTIONS WITH CHANGES IN BACTERIAL MIGRATION. COLLECTIVELY, THESE EXPERIMENTS WILL EXPLAIN HOW MICROBIAL AND HOST FACTORS DISRUPT THE LUNG EPITHELIUM, LEADING TO BACTERIAL DISSEMINATION, A FUNDAMENTAL PROCESS IN S. PNEUMONIAE PATHOGENESIS AND OTHER LUNG INFECTIONS.

METALLOPOLYMERS AS FUNCTIONAL METALLOPROTEIN MIMICS WITH SECONDARY COORDINATION SPHERE INTERACTIONS

CONTROL OF MUSCLE PROPRIOCEPTOR SENSITIVITY

FLUORESCENT ENHANCEMENT OF THE NITROGEN VACANCY CENTER IN NANOSCALE DIAMOND FOR BIOIMAGING APPLICATIONS

MECHANOPHENOTYPING RBC SUBPOPULATIONS IN ME/CFS - ABSTRACT MYALGIC ENCEPHALOMYELITIS, ALSO KNOWN AS CHRONIC FATIGUE SYNDROME (ME/CFS), AFFLICTS UP TO 2.5 MILLION IN THE UNITED STATES AND MILLIONS MORE WORLDWIDE. VERY LITTLE IS KNOWN ABOUT ITS CAUSE(S), MOST PHYSICIANS ARE NOT ADEPT AT DIAGNOSIS, AND NO BIOLOGICAL MARKERS OR APPROVED TREATMENTS ARE AVAILABLE. ME/CFS IS A HETEROGENEOUS AND UNPREDICTABLE DISEASE WITH SUBSETS OF SHARED SYMPTOMS BUT MOST PATIENTS EXPERIENCE POST-EXERTIONAL MALAISE, ORTHOSTATIC INTOLERANCE, AND COGNITIVE DISTURBANCES. PLASMA INFLAMMATORY AND OXIDATIVE STRESSES ARE INCREASED IN A SUBSET OF PATIENTS SUGGESTING A MULTISYSTEMIC DYSHOMEOSTASIS. STUDIES SUGGEST THAT IMPAIRED OXYGEN DELIVERY TO THE MUSCLES DURING HIGH METABOLIC DEMAND MAY EXPLAIN THE SYMPTOMS COMMON TO MOST PATIENTS. RED BLOOD CELL (RBC) DEFORMABILITY IS VITAL TO MICROVASCULAR OXYGENATION. WE HAVE OBSERVED THAT THE DEFORMABILITY OF RBC IN ME/CFS PATIENTS IS LOWER THAN THAT OF HEALTHY SUBJECTS, DUE TO AN INCREASE IN STIFFER SUBPOPULATION OF RBC IN THE PATIENTS. IN THIS PROPOSAL, WE WILL TEST THE HYPOTHESIS THAT THE DEFORMABILITY DISTRIBUTION IN RBC CAN SERVE TO DIFFERENTIATE ME/CFS PATIENTS FROM HEALTHY SUBJECTS, AND THAT THE INCREASED OXIDATIVE STRESS CONTRIBUTES TO ALTERED DEFORMABILITY DISTRIBUTIONS. WE WILL IMPLEMENT AN ULTRA-HIGH THROUGHPUT MICROFLUIDIC FRACTIONATOR TO SORT RBC BASED ON THEIR DEFORMABILITY, AND IN THE SORTED SUBPOPULATIONS, EXAMINE METABOLIC, STRUCTURAL, AND FUNCTIONAL CHANGES. WE WILL DEVELOP MACHINE LEARNING MODELS TO CORRELATE THE BIOPHYSICAL AND BIOCHEMICAL PROPERTIES OF THE RBC SUBPOPULATIONS WITH THE CLINICAL MEASURES TO CLASSIFY ME/CFS INTO SUBTYPES. SEVERAL UNDERGRADUATE AND MASTER'S STUDENTS WILL ACTIVELY ENGAGE AT EVERY STAGE OF THE PROJECT, AND WILL RECEIVE RIGOROUS TRAINING IN INTERDISCIPLINARY RESEARCH OF HIGH CLINICAL SIGNIFICANCE.

MOLECULAR MECHANISMS THAT REGULATE NEURAL CIRCUIT FORMATION

RUI: NEUROBEHAVIORAL ANALYSIS OF THE REGULATION OF COURTSHIP INITIATION IN DROSOPHILA MELANOGASTER

REACTIVE ION PLASMA TREATMENT OF CARDIOVASCULAR BIOMATERIALS TO UNDERSTAND THE EFFECT OF NANOTOPOGRAPHY ON ENDOTHELIALIZATION - PROJECT SUMMARY THIS PROJECT PROPOSES TO INVESTIGATE THE ROLE OF SURFACE TOPOGRAPHY IN ENDOTHELIALIZATION BY DECOUPLING IT FROM SURFACE CHEMISTRY USING REACTIVE ION PLASMA (RIP) OF PERIPHERAL VASCULAR GRAFT (PVG) BIOMATERIALS, INCLUDING A PROMISING MATERIAL: POLYVINYL ALCOHOL (PVA). OVER HALF OF PVGS MADE FROM SYNTHETIC MATERIALS FAIL WITHIN TWO YEARS OF IMPLANTATION AND THERAPIES TO REDUCE THE FACTORS CONTRIBUTING TO GRAFT FAILURE HAVE SHOWN NO BENEFIT IN LOWER EXTREMITY PVG OUTCOMES. BECAUSE THE TWO PREDOMINANT FAILURE MODES OF PVGS ARE THROMBOSIS (BLOOD CLOTTING) AND INTIMAL HYPERPLASIA (TISSUE BUILD-UP INSIDE THE GRAFT), AN IDEAL PVG BIOMATERIAL SHOULD BE RESISTANT TO BOTH. THE PRIMARY ATTRIBUTES OF SUCH A MATERIAL ARE THAT IT 1) HAVE COMPARABLE COMPLIANCE TO THE NATIVE VASCULATURE, 2) BE NON-THROMBOGENIC, AND 3) ENCOURAGE ENDOTHELIALIZATION. RIP-TREATED PVA IS A PROMISING PVG MATERIAL WHICH WE HAVE SHOWN PREVIOUSLY 1) IS EASILY MANUFACTURED WITH COMPLIANCE RANGING FROM THAT OF VENOUS TO ARTERIAL VASCULATURE, 2) IS LESS THROMBOGENIC THAN THE CURRENT CLINICAL STANDARD PVG MATERIAL, AND 3) ALLOWS ENDOTHELIAL PROGENITOR CELLS (EPCS) TO PROLIFERATE ON THE SURFACE FOR AT LEAST 48 HOURS IN VITRO. PROGRESS IN MANUFACTURING ENDOTHELIALIZABLE PVGS HAS BEEN HAMPERED BECAUSE THE APPROACHES PREDOMINANTLY INVOLVE CONJUGATION OF SMALL MOLECULES ONTO THE PVG MATERIAL, WHICH HAVE LIMITATIONS ASSOCIATED WITH COST, STABILITY, REPRODUCIBILITY, AND SCALABILITY AND DESPITE SIGNIFICANT ATTENTION HAVE YET TO BE TRANSLATED INTO THE CLINIC. OUR PROJECT IS FOCUSED ON USING RIP TREATMENT, A COMMON AND SCALABLE MANUFACTURING PROCESS, OF PVA TO DECOUPLE THE TWO SURFACE PROPERTIES KNOWN TO BE IMPORTANT IN THE ENDOTHELIALIZATION PROCESS: SURFACE CHEMISTRY AND TOPOGRAPHY, IN ORDER TO UNDERSTAND THE FUNDAMENTAL FACTORS THAT PROMOTE ENDOTHELIALIZATION AND TO ACHIEVE OUR LONG-TERM GOAL OF MANUFACTURING AN IMPROVED PVG. WE HAVE SHOWN THAT RIP-TREATMENT INTRODUCES REACTIVE SURFACE CHEMISTRY NECESSARY FOR CELL ADHESION IN THE FORM OF SURFACE NITROGEN, AS WELL AS NANOTEXTURE TO PVA AND TO VARYING DEGREES FOR DIFFERENT RIP TREATMENTS. WHILE MOST OF THE REACTIVE SURFACE CHEMISTRY INTRODUCED BY RIP IS STILL APPARENT AFTER 230 DAYS IN STORAGE, THE SURFACE BECOMES SMOOTH AND EPCS NO LONGER ADHERE OR PROLIFERATE AFTER STORAGE. WE WILL FIRST CHARACTERIZE THE CHANGES IN SURFACE CHEMISTRY AND TOPOGRAPHY DURING STORAGE IN ORDER TO UNDERSTAND THE NATURE OF THE MATERIAL SURFACE AS THE TOPOGRAPHY RELAXES (AIM 1). WE WILL THEN DECOUPLE THE EFFECTS OF SURFACE CHEMISTRY AND TOPOGRAPHY ON ENDOTHELIAL CELL (EC) AND EPC ATTACHMENT, PROLIFERATION, AND MIGRATION (AIM 2) AS WELL AS EC AND EPC FUNCTION WITH AND WITHOUT EXPOSURE TO FLUID FLOW (AIM 3). THIS UNDERSTANDING WILL ALLOW US TO DETERMINE THE EFFECT OF SURFACE CHEMISTRY AND TOPOGRAPHY ON THE IMPORTANT PROCESSES OF ENDOTHELIALIZATION AND ENGINEER A RAPIDLY ENDOTHELIALIZABLE PVG WHICH REMAINS PATENT LONGER THAN CURRENT CLINICAL MATERIALS. OUR STUDIES WILL AFFORD A MORE DETAILED UNDERSTANDING OF THE FACTORS WHICH GOVERN ENDOTHELIALIZATION OF SYNTHETIC BIOMATERIALS, PROVIDE A PLATFORM TO UNDERSTAND EC BIOLOGY, AND IMPROVE TRANSLATION OF PVGS WHICH CAN BE APPLIED TO OTHER BIOMATERIALS TO IMPROVE THEIR BIOINTEGRATION.

DEVELOPING A TOOLKIT FOR TRANSGENDER AND GENDER DIVERSE-AFFIRMING HEALTH COMMUNICATION: A COMMUNITY-BASED PARTICIPATORY RESEARCH PARTNERSHIP APPROACH - ABSTRACT MESSAGE TAILORING IN PUBLIC HEALTH CAMPAIGNS IS ESPECIALLY IMPORTANT IN HEALTH DISPARATE MINORITY POPULATIONS, SUCH AS TRANSGENDER AND GENDER DIVERSE (TGD) PEOPLE, THAT OFTEN HAVE BARRIERS TO CARE THAT INCLUDE DISTRUST OF THE HEALTH SYSTEM, SOCIETAL STIGMATIZATION, AND FINANCIAL BARRIERS. TGD HEALTH DISPARITIES INCLUDE, FOR EXAMPLE, ELEVATED RATES OF DIABETES, CARDIOVASCULAR DISEASE, ANXIETY, DEPRESSION, AND SUBSTANCE ABUSE COMPARED TO RATES FOR CISGENDER POPULATIONS. FURTHERMORE, THE TGD POPULATION IS SUBJECTED TO SOCIETAL EXCLUSION AND NEGATIVE PUBLIC PERCEPTION THAT CONTRIBUTES TO EXACERBATING THESE PROBLEMS. HOWEVER, LITTLE TO NO ATTENTION IS PAID TO TGD POPULATIONS WHEN DESIGNING HEALTH PROMOTION CAMPAIGNS FOR CONDITIONS FOR WHICH THIS POPULATION HAS ELEVATED RISK, EVEN THOUGH THE EFFECTIVENESS OF SUCH CAMPAIGNS IS WELL-DOCUMENTED FOR THE GENERAL POPULATION. HEALTH PROMOTION MESSAGING THAT CAN ENGAGE TGD PEOPLE IN NEEDED CARE AND PREVENTION ACTIVITIES IS AN ESSENTIAL TOOL IN ADDRESSING THEIR HEALTH DISPARITIES. HOWEVER, LAUNCHING SPECIFIC HEALTH PROMOTION CAMPAIGNS FOR A HOST OF HEALTH CONDITIONS IN HEALTH DISPARATE POPULATIONS, SUCH AS TGD COMMUNITIES, IS NOT FEASIBLE DUE TO THE VOLUME OF SPECIFIC CONDITIONS NEEDING TO BE ADDRESSED INDIVIDUALLY. FURTHERMORE, NATIONAL HEALTH PROMOTION CAMPAIGNS WITH TGD POPULATIONS IN MIND CAN STILL FAIL TO REACH TGD COMMUNITIES IN THE CENTRAL GREAT PLAINS BECAUSE THEY DO NOT MATCH THE LIVED REALITY OF THIS REGION WITH THE COMPOUNDING ISSUES OF HIGH STIGMATIZATION, AND LESS ACCESS TO CARE THAN IN COASTAL REGIONS. TO OVERCOME THESE CHALLENGES, THIS PROJECT WILL USE A COMMUNITY-BASED PARTICIPATORY RESEARCH NETWORK TO BUILD A TGD-AFFIRMING TOOLKIT FOR HEALTH COMMUNICATORS TO USE TO TAILOR MESSAGES TO THIS COMMUNITY WITH THE FOLLOWING SPECIFIC AIMS: 1) IDENTIFY AND EXPLORE POTENTIAL BARRIERS TO CARE GENERATED THROUGH NON-TGD TAILORED HEALTH COMMUNICATION AIMED AT TYPE 2 DIABETES, ANXIETY AND DEPRESSION, COLORECTAL CANCER, SUBSTANCE ABUSE, AND CERVICAL CANCER. THROUGH A SERIES OF INTERVIEWS WITH TGD INDIVIDUALS IN THE CENTRAL GREAT PLAINS AND NATIONAL TGD CONTENT CREATORS, THE IMPACT OF BOTH NON-TGD SPECIFIC AND TGD-SPECIFIC HEALTH MESSAGES WILL BE EXPLORED. QUALITATIVE AND CRITICAL CULTURAL ANALYSES COUPLED WITH ITERATIVE FEEDBACK FROM COMMUNITY AND NATIONAL BOARDS WILL GENERATE A PRELIMINARY TOOLKIT OF TGD-AFFIRMING PRINCIPLES FOR HEALTH COMMUNICATION. 2) THIS TOOLKIT WILL THEN BE TESTED THROUGH AN INNOVATIVE DIALOGIC WORKSHOP IN WHICH HEALTH COMMUNICATION PROFESSIONALS APPLY THE TOOLKIT TO A HEALTH PROMOTION CAMPAIGN AND SHARE IT WITH TGD COMMUNITY MEMBERS, AND COMMUNICATION PROFESSIONALS WHO IDENTIFY AS TGD, ENDING WITH ANY NEEDED REVISIONS OF THE TOOLKIT. THE MULTIDISCIPLINARY TRANS COLLABORATIONS RESEARCH TEAM HAS A SUCCESSFUL HISTORY OF FEDERAL FUNDING AND PRODUCING INNOVATIVE OUTCOMES THAT HAVE SIGNIFICANT SCIENTIFIC AND COMMUNITY IMPACT. THE WELL-ESTABLISHED LOCAL COMMUNITY AND NATIONAL ADVISORY BOARDS INFORM ALL PROJECTS. DEVELOPMENT OF A COMMUNITY-INFORMED TOOLKIT FOR TGD-AFFIRMING HEALTH MESSAGING IS ANOTHER STEP ON OUR LONG TERM GOAL OF ADDRESSING TGD HEALTH DISPARITIES IN UNDERSERVED AREAS.