University Of Waterloo

HIGH-RESOLUTION FUNCTIONAL IMAGING OF THE RETINA

INTERNATIONAL TOBACCO CONTROL POLICY SURVEY

TOBACCO CONTROL POLICY EVALUATION IN CHINA AND SOUTH KOREA: THE ITC ASIA PROJECT

ADAPTIVE OPTICS FLUORESCENCE LIFETIME OPHTHALMOSCOPY (AOFLIO) IN HEALTHY PEOPLE AND WITH DISEASE - PROJECT SUMMARY THE RETINAL PIGMENT EPITHELIUM (RPE) IS CRITICAL TO MAINTAINING THE HEALTH AND NORMAL FUNCTION OF PHOTORECEPTORS, AND IS THEREFORE INVOLVED IN MANY RETINAL DISEASES THAT CAUSE BLINDNESS. THROUGHOUT LIFE, RPE CELLS ACCUMULATE WASTE PRODUCTS THAT CLUSTER INTO FLUORESCENT LIPOFUSCIN GRANULES. IN STARGARDT DISEASE, THERE IS AN ACCELERATION OF LIPOFUSCIN ACCUMULATION AND CHANGES IN THE MOLECULAR COMPOSITION OF THE LIPOFUSCIN GRANULES. THE FLUORESCENCE OF LIPOFUSCIN MAKES IT POSSIBLE TO VISUALIZE THE MOSAIC OF RPE CELLS WITH AN ADAPTIVE OPTICS SCANNING LIGHT OPHTHALMOSCOPE. HOWEVER, CHARACTERIZING RPE CELLS FROM STRUCTURE AND INTENSITY ALONE DOES NOT PROVIDE SUFFICIENT INFORMATION ABOUT THE HEALTH OF THE CELLS. MEASUREMENT OF THE TIME DELAY IN FLUORESCENCE EMITTED FROM RPE IS RELATED TO THE NATURE OF THE FLUOROPHORES AND THEIR ENVIRONMENT INCLUDING THE COMPOSITION OF LIPOFUSCIN. DEVELOPMENT OF ADAPTIVE OPTICS FLUORESCENCE LIFETIME OPHTHALMOSCOPY (AOFLIO) OF THE HUMAN RPE MOSAIC WILL PROVIDE AN IMPORTANT TOOL TO CHARACTERIZE RPE CELLS IN BOTH HEALTHY AND DISEASED EYES, WHERE STRUCTURAL AND FUNCTIONAL BIOMARKERS MAY BE USED FOR RPE EVALUATION, AS WELL AS DIAGNOSING AND MONITORING DISEASE. THIS PROPOSAL AIMS TO DEVELOP AND ESTABLISH THE ABILITY OF AOFLIO TO DETECT CELLULAR-LEVEL CHANGES ACROSS THE MACULA ASSOCIATED WITH HEALTHY AGING AND STARGARDT DISEASE. FLUORESCENCE LIFETIME WILL BE MEASURED ACROSS THE RETINA BY COMPARING AOFLIO IN ADULT HUMAN SUBJECTS RANGING IN AGE FROM 20 TO 70 YEARS. THE ABILITY TO IDENTIFY RPE LAYER FLUORESCENCE LIFETIME CHANGES IN PATIENTS WITH STARGARDT DISEASE (10-30 YEARS) AND PROGRESSION OVER 3 YEARS WILL BE ASSESSED BY LONGITUDINAL AOFLIO MEASUREMENTS IN REGIONS OF ATROPHY, AT THE TRANSITION ZONE AND IN CLINICALLY-NORMAL RETINA. SOME OF THESE SUBJECTS WILL ALSO BE IMAGED WITH A CLINICAL PROTOTYPE FOR WIDEFIELD FLUORESCENCE LIFETIME IMAGING OPHTHALMOSCOPY (FLIO), GENERATING ONE-OF-A-KIND COMPARATIVE DATA. IN ADDITION, THE CURRENT AOFLIO INSTRUMENTATION WILL BE REPLACED WITH INNOVATIVE NEW TECHNOLOGY DESIGNED TO IMPROVE LIGHT EFFICIENCY AND RESOLVE FINER FEATURES THAN CURRENTLY POSSIBLE. THIS PROJECT AIMS TO EVALUATE THE PERFORMANCE OF AOFLIO, PREPARING US FOR FUTURE INVESTIGATIONS TO ESTABLISH AOFLIO AS AN IMPORTANT MEASURE OF BIOMARKERS OF RETINAL DEGENERATIVE DISEASE, ESTABLISHING AOFLIO AS A PROSPECTIVE ENDPOINT FOR USE IN CLINICAL TRIALS BY PROVIDING RAPID FEEDBACK ON THE EFFECTS OF POTENTIAL NEW THERAPIES.

QUANTUM ALGORITHMS IN THE LIGHT OF PHYSICS

TAS::57 3600::TAS "LEARNING IN LARGE-SCALE MODELS OF BIOLOGICAL COGNITION"

SIDE CHANNEL ANALYSIS OF FREE SPACE QUANTUM KEY DISTRIBUTION

"PROBABILITY THEORY FROM NEURONS TO COGNITION".

WY SAGE-GROUSE STUDIES IN NORTH EASTERN WYOMING CESU

EVALUATING THE IMPACT OF MANDATORY NUTRITION INFORMATION ON MENUS.

DEVELOPMENT OF QUANTUM COMPUTING ALGORITHMS

FREQUENCY-DEPENDENT POWER LIMITER

HIGH POWER PROTECTION, INTEGRATION AND PACKAGING OF SUPERCONDUCTOR ANALOG DIGITAL CONVERTERS

EXPANDING THE POWER OF A READING AND LANGUAGE DEVELOPMENT DATA REPOSITORY: LDBASE - PROJECT SUMMARY THE DATA CREATED BY LANGUAGE AND READING RESEARCHERS IS POWERFUL. SEVEN YEARS AGO, WE NOTED THAT THE FIELD OF READING AND LANGUAGE DEVELOPMENT RESEARCH WAS IDEALLY SUITED FOR THE CREATION OF A DOMAIN SPECIFIC DATA REPOSITORY, AND SUBSEQUENTLY BUILT ONE, LDBASE. WE SAW THAT THE BROAD FIELD OF READING AND LANGUAGE DEVELOPMENT RESEARCH, WHICH INTERSECTS THE FIELDS OF EDUCATION, PSYCHOLOGY, AND COMMUNICATION SCIENCE AND DISORDERS, AMONG OTHERS, WAS UNIQUE IN ITS NEED, AND POSITIONALITY, FOR SUCH A DOMAIN SPECIFIC DATA REPOSITORY. FIRST, MANY OF THE PROJECTS ARE GRANT FUNDED, WHICH MEANS THERE IS TOP-DOWN PRESSURE FROM GRANTING AGENCIES TO SHARE DATA. SECOND, THE COMMUNITY IS UNIQUE IN BEING WELL POISED TO CAPITALIZE ON THE POWER OF SHARED DATA. A DOMAIN SPECIFIC REPOSITORY ALLOWS FOR A ONE-STOP SHOP FOR FACILITATING DATA SHARING AND REUSE, FACILITATING THE RESEARCH OF THE FIELD TO SOLVE THE PRESSING PROBLEMS FACED BY INDIVIDUALS WITH LANGUAGE RELATED DISABILITIES. BASED ON TOTAL NUMBER OF DATASETS SHARED, DATASETS DOWNLOADED, GENERAL COMMUNITY ENGAGEMENT, PUBLICATIONS, WHITE PAPERS, AND FUNDED GRANTS, LDBASE HAS BEEN A DRIVER OF SCIENTIFIC INNOVATION IN THE FIELD. WITH THIS PROPOSAL, WE PRIORITIZE WORK IN INNOVATING IN THE DATA REPOSITORY FIELD TO INCREASE OUR SUPPORT OF DATA SHARING, DATA REUSE, AND INTERCONNECTIVITY WITH OTHER DATA REPOSITORIES, AS WELL AS FEATURES AND TRAININGS FOCUSING ON THE NEEDS OF THE READING AND LANGUAGE DEVELOPMENT FIELD, THROUGH FOUR NEW SPECIFIC AIMS. SPECIFIC AIM 1 EXPAND LDBASE TO INCLUDE STATE-OF-THE-SCIENCE DATA REPOSITORY TECHNIQUES TO INCREASE INTEROPERABILITY. SPECIFIC AIM 2. BUILD A COMMUNITY ENTHUSIASTIC ABOUT AND TRAINED FOR DATA SHARING. SPECIFIC AIM 3. INCREASE USERS AND COMMUNITY ENGAGEMENT. SPECIFIC AIM 4. DEMONSTRATE THE POWER OF DATA REUSE BY ANSWERING IMPORTANT RESEARCH QUESTIONS THROUGH INTEGRATED ANALYSES AND CREATING COMBINED DATASETS FOR COMMUNITY USE. IN A TIME OF INCREASED FOCUS ON DATA SHARING DUE TO TOP-DOWN DEMANDS FROM FUNDERS, INVESTIGATORS IN THE FIELD OF READING AND LANGUAGE DEVELOPMENT NEED AN EASY-TO-USE DATA REPOSITORY TO STORE THEIR DATA, A GAP WHICH LDBASE FILLS. IN ADDITION, THE POWER OF SECONDARY DATA REUSE, ACCESS TO POWERFUL TOOLS LIKE APPLICATION PROGRAMMING INTERFACE (API) AND DATA INTEGRATION, EDUCATIONAL OPPORTUNITIES, AND STANDARDIZATION OF FIELD NORMS, MEANS LDBASE WILL BECOME A CRITICAL INFRASTRUCTURE FOR READING AND LANGUAGE DEVELOPMENT RESEARCH.

WILDLIFE RESEARCH IN PRB

AN INTEGRATED ANALOG WIDE-BAND PROCESSOR WITH INTERFERENCE CANCELING CAPABILITY

DESIGN AND ATTACK-RESISTANCE ANALYSIS OF LIGHTWEIGHT CRYPTOGRAPHIC ALGORITHMS AND PROTOCOLS

DEVELOPMENT OF SUPERCONDUCTOR NIOBIUM-BASED MILLIMETER-WAVE FILTERS

NANOMETER SCALE MAGNETIC RESONANCE IMAGING OF ELECTRON AND NUCLEAR SPINS

TAS::57 3600::TAS "A NEURAL INFORMATION FIELD APPROACH TO COMPUTATIONAL COGNITION" DATED 29 MAY 2013

DETERMINISTIC DETECTION AND CONTROL OF CORRELATED STATES IN TRANSITION METAL DICHALCOGENIDE MOIRE HETEROSTRUCTURES

UNIFIED APPROACH TO FATIGUE AND RELIABILITY PROGNOSTICS OF ADVANCED ENGINEERING MATERIALS AND STRUCTURES -- AN EXTENSION OF THE UNIGROW FATIGUE CRACK

TAS::57 3600::TAS "DISCOVERING STRUCTURE VIA MATRIX RANK MINIMIZATION"

TAS::57 3600::TAS"CONVEX RELAXATION FOR HARD PROBLEM IN DATA MINING AND SENSOR LOCALIZATION"

BEHIND ARMOR BLUNT TRAUMA ASSESSMENT USING ADVANCED COMPUTATIONAL HUMAN MODELS

A NEW PARADIGM FOR BETA-LACTAMASE INHIBITION RESEARCH

TAS::57 3600::TAS "OPTIMAL SENSOR LOCATION FOR DISTRIBUTION PARAMETOR SYSTEMS INSTITUTION, DATED 22 AUG 2013"

GRAPHS AND MATROIDS

BLM WY GREATER SAGE GROUSE SEASONAL HABITAT ASSESSMENT AND MODELING RM CESU

AN EXTENSION OF THE UNIGROW FATIGUE CRACK GROWTH MODEL 2013-2016; UNIFIED APPROACH TO FATIGUE AND RELIABILITY

TAS::57 3600::TAS "COMPUTATION OF OPTIMAL ACTUATOR/SENSOR LOCATIONS"

BIOLOGICAL RESPONSES TO INCREASING WATER TEMPERATURES IN LAKES OF THE BARROW/ATQASUK FOCUS WATERSHED

HIGH-Q RECONFIGURABLE LOW TEMPERATURE SUPERCONDUCTOR FILTERS

ALGORITHMIC ASPECTS OF MATROID MINORS

FY19 - F19AS00231 WHITE-NOSE SYNDROME RESEARCH GRANTS

ASSESSING RANGE-WIDE CONNECTIVITY OF SAGE-GROUSE PRIORITY AREAS OF CONSERVATION

COMBINATORIAL AND GEOMETRIC STRUCTURES, CONVEX OPTIMIZATION LEADING TO MATRIX RECOVERY

BASIC RESEARCH FOR AOARD PROPOSAL 19IOA077 "THROUGH A RING OF FIRE: INFORMATION PRESERVATION ACROSS HORIZONS", DATED 3 JUL 19 (THE GRANTEE'S TECHNICAL

NEW CA UNIV. WATERLOO

TRANSMITTER TECHNOLOGIES/ARCHITECTURES FOR COMMUNICATIONS

COMBINATORIAL AND GEOMETRIC STRUCTURES, CONVEX OPTIMIZATION LEADING TO LOW RANK MATRIX RECOVERY, ROBUST OPTIMIZATION AND EFFICIENT COMBINATORIAL ALGO

MATHEMATICS OF PRIMAL-DUAL ALGORITHMS FOR LARGE-SCALE OPTIMIZATION, COMBINATORIAL AND GEOMETRIC STRUCTURES, MIN-MAX THEOREMS

MINIATURE LOW FREQUENCY TUNABLE LTS FILTERS

ENGINEERING A FULLY CONNECTED GRAPH OF TRAPPED ION QUBITS

MINOR-CLOSED CLASSES OF REPRESENTABLE MATROIDS

ALGORITHMIC COOLING AND QUANTUM SIMULATIONS

LANDSCAPE FACTORS INFLUENCING FUNCTIONAL CONNECTIVITY FOR GREATER SAGE GROUSE

GENERATION, DETECTION, AND CONTROL OF COHERENT MAGNON TRANSPORT AND CONDENSATION IN A TWO-DIMENSIONAL MAGNET

DEVELOPMENT OF KA-BAND MULTIPLEXERS AND ISOLATORS FOR DIGITAL RECEIVERS

ROUTE TO QUANTUM ANOMALOUS HALL EFFECT USING MAGNETIC VAN DER WAALS HETEROSTRUCTURES

CAUSALITY AND INFORMATION DYNAMICS IN NETWORKED SYSTEMS WITH MANY AGENTS (ARO 10.3)

SECURING LARGE-SCALE MULTI-HOP MIMO MANET WITH DHT-BASED HIERARCHICAL ROUTING AND CAPACITY OPTIMIZATION

SECURING LARGE-SCALE MULTI-HOP MIMO MANET WITH DHT-BASED HIERARCHICAL ROUTING AND CAPACITY OPTIMIZATION

SECURING MIMO MANET AND IT S CAPACITY OPTIMIZATION

TOWARDS A MATROID MINORS STRUCTURE THEOREM

RF PROBE TESTING OF LOW TEMPERATURE SUPERCONDUCTOR CIRCUITS

EASTERN POPULATION SANDHILL CRANE DISTRIBUTION AND MIGRATION CHRONOLOGY IN THE ATLANTIC FLYWAY

RANGEWIDE GENETIC CONNECTIVITY OF GREATER SAGE GROUSE.

MODELING GREATER SAGE-GROUSE POPULATION DYNAMICS IN A MULTIPLE-USE LANDSCAPE OF THE EASTERN RANGE

2016 SUMMER SCHOOL ON LARGE-SCALE BRAIN MODELLING

2015 SUMMER SCHOOL ON LARGE-SCALE BRAIN MODELLING

GENETIC EVALUATION OF FISH HEALTH FROM FIELD COLLECTED FISH

5TH INTERNATIONAL WORKSHOP ON CONSUMING LINKED DATA (COLD2014)

NENGO SUMMER SCHOOL 2017

CESU UNIV WATERLOO, HABITAT MODELING SUGGESTED VENDOR: SUGGESTED GRANTS SPECIALIST: FAITH GRAVES HEADER TEXT: NEW CESU - UNIV OF WATERLOO, HABITAT MODELING AND PRIORITIZATION IN WYOMING. MULTI YEAR