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Source: IRS Form 990 via ProPublica Nonprofit Explorer
Total Revenue
▼$1.4B
Total Contributions
$749.3M
Total Expenses
▼$1.5B
Total Assets
$4.8B
Total Liabilities
▼$1.2B
Net Assets
$3.6B
Officer Compensation
→$7.2M
Other Salaries
$688.7M
Investment Income
▼$10.4M
Fundraising
▼$0
Source: USAspending.gov · Searched by organization name
VA/DoD Awards
$43.1M
VA/DoD Award Count
100
Funding from the Department of Veterans Affairs and/or Department of Defense.
Total Federal Funding
$52.9M
Awards Found
114
| Awarding Agency | Description | Amount | Fiscal Year | Period |
|---|---|---|---|---|
| VA/DoDDepartment of Defense | NEXT-GENERATION PEPTIDE-BASED MEDICINES FOR MALARIA | $2.4M | FY2022 | Sep 2022 – Sep 2026 |
| Department of Health and Human Services | HUMAN-INFORMED DATA-DRIVEN DEVELOPMENT OF NEXT-GENERATION T CELL VACCINE AGAINST MALARIA - PA-19-077 DOOLAN: PROJECT SUMMARY MALARIA REMAINS A GLOBAL PUBLIC HEALTH PROBLEM WITH NEARLY HALF OF THE WORLD'S POPULATION AT RISK. AN EFFECTIVE MALARIA VACCINE WOULD PREVENT ALMOST HALF A MILLION DEATHS AND OVER 200 MILLION CLINICAL CASES EACH YEAR AND HELP ERADICATE THE DISEASE. THE MOST EFFECTIVE EXPERIMENTAL MALARIA VACCINATION REGIMENS TO DATE ARE RADIATION- ATTENUATED SPOROZOITES (RAS; PFSPZ) AND INFECTIOUS SPOROZOITES ADMINISTERED UNDER CHEMOPROPHYLAXIS (CPS). PROTECTIVE IMMUNITY IS BELIEVED TO BE MEDIATED BY CD8+ T CELLS WHICH ATTACK THE PARASITE DURING THE PRE- ERYTHROCYTIC (PE) LIVER-STAGE OF INFECTION. HOWEVER, THE KEY ANTIGENS UNDERLYING THIS PROTECTION ARE LARGELY UNKNOWN. WE HAVE DEVELOPED AND APPLIED A PROTEOME-WIDE T CELL SCREENING APPROACH TO IDENTIFY THE SUBSET OF KEY ANTIGENS TARGETED BY T CELL RESPONSES FROM THE COMPLETE PLASMODIUM FALCIPARUM PARASITE PROTEOME. WE HAVE SHOWN THAT THE ANTIGENS PREFERENTIALLY RECOGNIZED BY T CELLS ARE DISTINCT FROM ANTIBODY TARGETS. HERE, WE WILL CHARACTERIZE AND CREDENTIAL HIGHLY RANKED PRE-ERYTHROCYTIC P. FALCIPARUM T CELL ANTIGENS FROM OUR UNIQUE DATASET, FOCUSING ON THOSE THAT ARE CATEGORIZED AS EXCLUSIVELY T CELL TARGETS, SINCE T CELLS DIRECTED AGAINST LIVER- STAGE ANTIGENS ARE CONSIDERED THE PRIMARY IMMUNE EFFECTORS REQUIRED FOR STERILE IMMUNITY AGAINST MALARIA WHICH PREVENTS DISEASE AND STOPS TRANSMISSION. OUR SELECTION CRITERIA WILL CONSIDER EXTENT OF SEQUENCE CONSERVATION ACROSS PLASMODIUM STRAINS AND SPECIES, TO TARGET A VACCINE THAT CONFERS STRAIN TRANSCENDING AND CROSS-SPECIES PROTECTION. WE WILL USE CLINICALLY RELEVANT SELECTION CRITERIA GOVERNED BY THE CAPACITY OF THE ANTIGEN TO PROTECT AGAINST VIRULENT P. YOELII PARASITE CHALLENGE IN ESTABLISHED PRECLINICAL MODELS AND TO BE RECOGNIZED BY RECALL PLASMODIUM-SPECIFIC IMMUNE RESPONSES IN PROTECTIVE HUMAN MODELS. WE WILL USE TWO INNOVATIVE VACCINE DELIVERY PLATFORMS SELECTED FOR CAPACITY TO INDUCE ROBUST AND SUSTAINED T CELL RESPONSES, WITH A SPECIFIC FOCUS ON THE INDUCTION OF LIVER-SPECIFIC RESIDENT MEMORY T CELLS (TRM) TARGETING THE PUTATIVE SITE OF IMMUNE ACTION. OUR SELECTED REGIMENS INCLUDE “PRIME-TARGET” COMPRISING A DNA PRIME FOLLOWED BY ADENOVIRUS BOOST DELIVERED INTRAVENOUSLY TO TARGET THE LIVER, AND A LIPOSOMAL MRNA VACCINE PLATFORM WITH AN INCORPORATED AGONIST (CA) TO ACTIVATE NKT CELLS AND LINK INNATE AND ADAPTIVE IMMUNITY; BOTH PLATFORMS CAN INDUCE SUSTAINED T CELL RESPONSES AND ARE CAPABLE OF PROTECTING MICE AGAINST SPOROZOITE CHALLENGE. WE WILL ASSIGN PRIORITIES FOR VACCINE DEVELOPMENT ACCORDING TO THEIR CREDENTIALS, EVALUATE COMBINATIONS FOR SYNERGY, AND DOWN-SELECT FOR CLINICAL DEVELOPMENT THE SET OF ANTIGENS THAT HAVE A MAXIMUM LIKELIHOOD OF INDUCING ROBUST AND SUSTAINED PROTECTIVE IMMUNITY AGAINST MALARIA IN HUMANS. THE OPTIMAL VACCINE CANDIDATE DEFINED WITH THIS PRECLINICAL DEVELOPMENT STRATEGY COULD BE TRANSITIONED DIRECTLY TO CLINICAL DEVELOPMENT WITH THE ULTIMATE GOAL OF DEPLOYING IN THE FIELD AN EFFECTIVE RATIONALLY-DESIGNED GENOME-BASED VACCINE THAT WOULD INDUCE DURABLE T-CELL MEDIATED PROTECTION AND AMELIORATE DISEASE IN ALL AT-RISK INDIVIDUALS. | $1.9M | FY2022 | Sep 2022 – Aug 2026 |
| VA/DoDDepartment of Defense | DRUGS FROM BUGS: DEVELOPING NEW INFLAMMATORY BOWEL DISEASE DRUGS FROM GUT BACTERIA-DERIVED BIOACTIVES | $1.8M | FY2021 | Jul 2021 – Dec 2026 |
| Department of Health and Human Services | WHAT CAUSES LOW BACK PAIN TO FLARE: HAS A MAJOR OPPORTUNITY TO UNDERSTAND BACK PAIN BEEN MISSED? - PROJECT SUMMARY/ABSTRACT LOW BACK PAIN (LBP) IS TRADITIONALLY VIEWED AS EITHER A TRANSIENT CONDITION WITH ACUTE EPISODES OR A CHRONIC PERSISTING CONDITION. HOWEVER, IT IS INCREASINGLY RECOGNIZED THAT FOR MOST (>80% OF CASES), LBP HAS A VARIABLE AND ONGOING TRAJECTORY CHARACTERIZED BY FLUCTUATING SYMPTOMS – WITH PERIODS OF WORSE SYMPTOMS REFERRED TO AS “FLARES”. CURRENT WORK REGARDING RISK FACTORS FOR LBP ONLY CONSIDERS THOSE ASSOCIATED WITH A NEW EPISODE OR THE TRANSITION TO CHRONIC LBP. FINDINGS FROM THAT WORK HAS FAILED TO DELIVER EFFECTIVE STRATEGIES TO PREVENT NEW EPISODES OR CHRONICITY, NOR REDUCE THE EXCESSIVE BURDEN OF LBP. THE UNDERLYING PREMISE OF THIS PROPOSAL IS THAT FLUCTUATION OR FLARING OF LBP IS MEDIATED BY TRANSIENT/FLUCTUATING EXPOSURE TO A RANGE OF FACTORS ACROSS MULTIPLE DOMAINS, THAT DIFFER BETWEEN INDIVIDUALS, AND IDENTIFICATION OF THESE FACTORS COULD PROVIDE A BASIS FOR A COMPLETELY NEW MODEL TO PERSONALIZE CARE. THIS PROJECT WILL TAKE A FRESH LOOK AT LBP BY DIRECTLY ADDRESSING THIS QUESTION USING INNOVATIVE METHODS THAT ARE ENABLED BY RECENT ADVANCES IN TECHNOLOGY. THE WORK IS BASED ON OUR EXTENSIVE COLLABORATION WITH PEOPLE WITH LBP THAT HAS PROVIDED CRITICAL INSIGHT INTO HOW FLARES ARE DEFINED (WHICH SURPRISINGLY IS NOT BASED ON PAIN ALONE) AND THEIR PERSPECTIVE OF THE POTENTIAL CAUSES FOR LBP FLARES. OUR MULTIDISCIPLINARY RESEARCH TEAM PROPOSE AN INNOVATIVE CASE-CROSSOVER STUDY THAT WILL ADDRESS TWO AIMS. AIM 1 WILL EXAMINE, AT MULTIPLE TIMEPOINTS OVER A PERIOD OF 3 MONTHS, AN ARRAY OF CANDIDATE BIOLOGICAL/BEHAVIORAL, PSYCHOLOGICAL, SOCIAL, AND ENVIRONMENTAL RISK FACTORS FOR LBP FLARE THAT HAVE BEEN SELECTED BASED ON CONSUMER PERSPECTIVE, LITERATURE REVIEW AND OUR EXTENSIVE PRELIMINARY STUDIES. MEASURES WILL BE MADE IN THE “REAL WORD” USING ADVANCED WEARABLE AND ONLINE TECHNOLOGIES. AIM 2 WILL INVOLVE AN EMBEDDED STUDY OF INDIVIDUALS FROM THE MAIN PARTICIPANT COHORT WHO FLARE FREQUENTLY. FOR 7 DAYS, ELIGIBLE INDIVIDUALS WILL UNDERGO MORE INTENSIVE “REAL- WORLD” PHYSIOLOGICAL AND BIOMECHANICAL MEASURES USING AN INNOVATIVE COMBINATION OF WEARABLE SENSORS AND HOME-BASED SAMPLE/DATA COLLECTION TO INVESTIGATE POTENTIAL MECHANISMS UNDERLYING TWO SURPRISING PRELIMINARY OBSERVATIONS: (1) THAT POOR SLEEP IS A POTENT RISK FACTOR FOR A SUBSEQUENT FLARE (AS OPPOSED TO THE TRADITIONAL VIEW THAT PAIN INTERFERES WITH AND CAUSES POOR SLEEP), AND (2) THAT LOW RATHER THAN HIGH PHYSICAL ACTIVITY IS A RISK FACTOR FOR LBP FLARE. WE AIMS TO IDENTIFY NOT ONLY IF, BUT HOW, DAILY VARIATIONS IN SLEEP QUALITY AND PHYSICAL ACTIVITY – TWO OF THE MOST IMPORTANT, YET MODIFIABLE HEALTH BEHAVIORS – DRIVE FLARE OF LBP. TOGETHER THESE DATA WILL FILL A MAJOR GAP BY PROVIDING NEW UNDERSTANDING OF MECHANISMS THAT DRIVE THE FLUCTUATING EXPERIENCE OF LBP. SUCH FACTORS WILL PROVIDE THE FOUNDATION TO DEVELOP AND TEST MORE TARGETED AND PERSONALIZED INTERVENTIONS TO REDUCE THE ENORMOUS – AND WORSENING – BURDEN OF THIS CONDITION ON SUFFERERS AND SOCIETY. | $1.7M | FY2022 | Sep 2022 – Aug 2027 |
| VA/DoDDepartment of Defense | DISCOVERY OF NEW TREATMENTS AND BIOMARKERS FOR NEUROGENIC HETEROTOPIC OSSIFICATIONS FOLLOWING SPINAL CORD INJURIES | $1.5M | FY2021 | Jul 2021 – Jun 2026 |
| VA/DoDDepartment of Defense | PEPTIDE INHIBITORS TARGETING SODIUM CHANNELS TO TREAT AMYOTROPHIC LATERAL SCLEROSIS | $1.4M | FY2023 | Mar 2023 – Feb 2026 |
| VA/DoDDepartment of Defense | SPINEPASS: SPINE SELF-MANAGEMENT TECHNIQUES FOR PERSISTENT HEADACHE AFTER CONCUSSION-PHYSICAL THERAPY TARGETING AUTONOMIC AND DURA MATER FUNCTION | $1.3M | FY2024 | Sep 2024 – Sep 2028 |
| Department of Health and Human Services | ELUCIDATING SENSORIAL AND FUNCTIONAL CHARACTERISTICS OF TOPICAL FORMULATIONS | $1.2M | FY2019 | Sep 2019 – Aug 2025 |
| VA/DoDDepartment of Defense | TOPICAL VENOM ACTIVATED HYDROGEL HEMOSTATIC (PROCOAGULANT + ANTIFIBRINOLYTIC) AGENT | $1.2M | FY2022 | Apr 2022 – Mar 2026 |
| VA/DoDDepartment of Defense | PREDICTING EARLY-STAGE MELANOMA AT HIGH RISK OF RECURRENCE THROUGH MULTIOMICS PROFILING | $1.2M | FY2025 | Sep 2025 – Aug 2028 |
| VA/DoDDepartment of Defense | A FIRST-IN-CLASS CALCIUM CHANNEL INHIBITOR FOR THE TREATMENT OF ADVANCED METASTATIC PROSTATE CANCERS RESISTANT TO NEXT-GENERATION ANTIANDROGEN THERAPY | $1.1M | FY2025 | Jul 2025 – Jun 2028 |
| VA/DoDDepartment of Defense | PROTEOMIC BIOMARKERS FOR ALS DISEASE PROGNOSIS AND PROGRESSION MONITORING. | $1.1M | FY2025 | Apr 2025 – Mar 2027 |
| VA/DoDDepartment of Defense | EXPLOITING THE REMODELING OF CA2+ SIGNALING IN BREAST CANCER CELL MICROENVIRONMENTS TO CONTROL METASTASIS AND TO SPECIFICALLY TARGET BRAIN METASTASES | $1.1M | FY2017 | Apr 2017 – Mar 2021 |
| VA/DoDDepartment of Defense | PRECLINICAL VALIDATION OF A NOVEL DRUG LEAD TO TREAT TUBERCULOSIS | $1.1M | FY2018 | Sep 2018 – Aug 2023 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS "BASIC RESEARCH FOR AOARD 144046 "QUANTUM MICRORHEOLOGY, DATED 15 JAN 14" (THE GRANTEE'S TECHNICAL PROPOSAL)" | $1M | FY2014 | Sep 2014 – Aug 2017 |
| VA/DoDDepartment of Defense | UNDERSTANDING ACUTE TO CHRONIC BACK PAIN PATHWAYS AND TESTING NEW SOLUTIONS. NEW AWARD. | $1M | FY2020 | Sep 2020 – Sep 2024 |
| VA/DoDDepartment of Defense | EXPLOITING THE REMODELING OF CA2+ SIGNALING IN BREAST CANCER CELL MICROENVIRONMENTS TO CONTROL METASTASIS AND TO SPECIFICALLY TARGET BRAIN METASTASES | $990.5K | FY2017 | Apr 2017 – Mar 2021 |
| Agency for International Development | RAPID AND NOVEL SURVEILLANCE TOOL FOR DETECTING ARBOVIRUS TRANSMISSION HOTSPOTS IN BRAZIL | $922.4K | FY2017 | Oct 2016 – Sep 2019 |
| Department of Health and Human Services | DISCOVERY OF POLYMYXIN-BASED ANTIBACTERIAL AGENTS ACTIVE AGAINST MULTI-DRUG RESIS | $919.6K | FY2012 | May 2012 – Oct 2017 |
| Department of Health and Human Services | MURINE ATLAS OF GENITOURINARY DEVELOPMENT | $818.4K | FY2004 | Sep 2004 – Jul 2011 |
| VA/DoDDepartment of Defense | ENDOMETRIOSIS SUSCEPTIBILITY GENES IN ENDOMETRIAL STEM/PROGENITOR CELLS | $789.4K | FY2019 | Aug 2019 – Jul 2023 |
| VA/DoDDepartment of Defense | ENHANCEMENT OF NATURAL KILLER CELL FUNCTION FOR THERAPEUTIC TARGETING AND ELIMINATION OF METASTATIC BREAST CANCER | $763.5K | FY2021 | Jan 2021 – Dec 2024 |
| VA/DoDDepartment of Defense | DISCOVERING THERAPEUTIC VULNERABILITIES OF CIRCULATING MELANOMA CLUSTERS | $745K | FY2024 | Jun 2024 – May 2027 |
| VA/DoDDepartment of Defense | UNDERSTANDING THE ROLE OF IMMATURE MYELOID CELLS IN EARLY MELANOMA ESTABLISHMENT | $744.7K | FY2022 | Sep 2022 – Sep 2025 |
| VA/DoDDepartment of Defense | MELANOMA RESEARCH PROGRAM | $744.3K | FY2022 | Sep 2022 – Sep 2026 |
| VA/DoDDepartment of Defense | THERAPEUTIC INHIBITION OF NEUTROPHIL ACTIVITY AS A DISEASE-MODIFYING TREATMENT FOR AMYOTROPHIC LATERAL SCLEROSIS | $731K | FY2022 | Jul 2022 – Jul 2026 |
| VA/DoDDepartment of Defense | QUANTUM CONTROL OF BIOMOLECULAR VIBRATIONS | $727.6K | FY2020 | Sep 2020 – Sep 2025 |
| VA/DoDDepartment of Defense | DANGER SIGNALING, TRAUMATIC BRAIN INJURY, AND EPILEPTOGENESIS. | $705.6K | FY2021 | Jul 2021 – Jun 2026 |
| VA/DoDDepartment of Defense | DECIPHERING AND INTERCEPTING MESSAGES BETWEEN CANCER CELLS AND CELLS IN THE BREAST CANCER MICROENVIRONMENT: ROLES FOR INTRACELLULAR CALCIUM SIGNALING | $695.6K | FY2020 | Sep 2020 – Sep 2024 |
| VA/DoDDepartment of Defense | MECHANISMS AND TREATMENTS OF HETEROTOPIC OSSIFICATION FOLLOWING SPINAL CORD INJURIES | $690.5K | FY2015 | Sep 2015 – Sep 2018 |
| VA/DoDDepartment of Defense | RP-115: A NOVEL BIOMARKER OF ASTROCYTE DYSFUNCTION AND GLUTAMATE DYSREGULATION IN BRAIN AND SPINAL CORD IN ALS | $676.3K | FY2023 | Aug 2023 – Jul 2026 |
| VA/DoDDepartment of Defense | INVESTIGATING THE INFLUENCE OF TAILORED WALL TEMPERATURE PROFILING ON HYPERSONIC BOUNDARY LAYER TRANSITION | $672.2K | FY2023 | Sep 2023 – Sep 2026 |
| VA/DoDDepartment of Defense | NEW GRANT | $633.1K | FY2023 | May 2023 – Apr 2027 |
| VA/DoDDepartment of Defense | NONEQUILIBRIUM QUANTUM DYNAMICS IN SUPERFLUID HELIUM | $631.3K | FY2017 | Aug 2017 – Oct 2022 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD 134134 "RE-ENGINEERING THE STOMATOPOD EYE, NATURE'S MOST COMPREHENSIVE VISUAL SENSOR, DATED 28 MAR 12" (THE GRANTEE'S TECHNI | $618.3K | FY2013 | Sep 2013 – Sep 2016 |
| VA/DoDDepartment of Defense | PREDICTING EARLY-STAGE MELANOMA AT HIGH RISK OF RECURRENCE THROUGH MULTIOMICS PROFILING | $563.7K | FY2025 | Sep 2025 – Aug 2028 |
| VA/DoDDepartment of Defense | TARGETING COMPLEMENT IN POST-TRAUMATIC EPILEPTOGENSIS | $545K | FY2017 | Sep 2017 – Sep 2022 |
| VA/DoDDepartment of Defense | EXPERIMENTAL STUDY OF NON-EQUILIBRIUM TURBULENCE-CHEMISTRY INTERACTION IN EXTERNAL HYPERSONIC FLOWS | $540K | FY2022 | Mar 2022 – Feb 2026 |
| VA/DoDDepartment of Defense | CLEC9A TARGETING ANTIBODIES AS A NEW IMMUNOTHERAPY FOR PROSTATE CANCER | $530.9K | FY2015 | Sep 2015 – Aug 2018 |
| VA/DoDDepartment of Defense | A NOVEL MEDIATOR OF CHOLANGIOCARCINOMA THAT HAS POTENTIAL AS A DIAGNOSTIC AND TREATMENT TARGET | $520K | FY2022 | Aug 2022 – Jul 2025 |
| VA/DoDDepartment of Defense | TARGETING CEP55 IN TRIPLE-NEGATIVE BREAST CANCER | $519.6K | FY2022 | Sep 2022 – Aug 2026 |
| VA/DoDDepartment of Defense | PREDICTING EARLY-STAGE MELANOMA AT HIGH RISK OF RECURRENCE THROUGH MULTIOMICS PROFILING | $506.8K | FY2025 | Sep 2025 – Aug 2028 |
| Department of Health and Human Services | FORMULATION DRUG PRODUCT QUALITY ATTRIBUTES IN DERMAL PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELS FOR TOPICAL DERMATOLOGICAL DRUG PRODUCTS AND TRANSDERMAL DELIVERY SYSTEMS | $500K | FY2018 | Sep 2018 – Aug 2021 |
| Department of Health and Human Services | ATTENUATED WEST NILE VIRUS VACCINE | $487.1K | FY2005 | Jul 2005 – Jun 2011 |
| VA/DoDDepartment of Defense | SNAKE VENOM-BASED RAPID WOUND SEALANT | $480.6K | FY2018 | Sep 2018 – Mar 2021 |
| VA/DoDDepartment of Defense | PROOF-OF-CONCEPT STUDIES FOR A NOVEL IMMUNOTHERAPY FOR TRIPLE-NEGATIVE BREAST CANCER AND COMPANION DIAGNOSTIC | $466.2K | FY2024 | Apr 2024 – Sep 2026 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD PROPOSAL 20IOA056 "ADVANCED GROUND TESTING AND SIMULATION OF THE BOUNDARY LAYER TRANSITION (BOLT) FLIGHT EXPERIMENT", DATED 1 | $450K | FY2020 | Aug 2020 – Feb 2024 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD PROPOSAL 20IOA018 "HEATED WALL SUPERSONIC COMBUSTION TESTING OF HYDROCARBONS IN AXISYMMETRIC MODELS IN THE T4/X3R SHOCK TUNNE | $450K | FY2020 | Sep 2020 – Dec 2023 |
| VA/DoDDepartment of Defense | ACHIEVING HIGH SENSITIVITY IN CAVITY OPTOMECHANICAL MAGNETOMETRY | $449.9K | FY2013 | Dec 2012 – Nov 2014 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS "SENSOR SCHEDULING AND FUSION FOR CATALOG MAINTENANCE OF RESIDENT SPACE OBJECTS" | $434.7K | FY2010 | Sep 2010 – Aug 2014 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS 'QUANTUM MICROSCOPY: REACHING AND SURPASSING THE QUANTUM LIMITS TO BIOLOGICAL IMAGING' | $398.2K | FY2017 | Sep 2017 – Aug 2020 |
| VA/DoDDepartment of Defense | NICOP - OPTIMIZING COGNITIVE PERFORMANCE BY MIMICKING SLOW-WAVE SLEEP IN THE AWAKE BRAIN. | $382.9K | FY2017 | Sep 2017 – Sep 2022 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS CLUSTER-STATE QUANTUM ERROR-CORRECTION BASED ON ADS/CFT | $300K | FY2018 | Aug 2018 – Aug 2021 |
| VA/DoDDepartment of Defense | CHARACTERIZATION AND VALIDATION OF A NEW MOUSE MODEL OF SPONTANEOUS ENDOMETRIOSIS TO IMPLEMENT TRANSLATION OF BASIC RESEARCH TO THE CLINIC | $297.4K | FY2023 | Mar 2023 – Feb 2026 |
| VA/DoDDepartment of Defense | EPITHELIAL TISSUE MECHANICS: A NEW KEY TO RELAPSE IN CHRONIC INFLAMMATORY BOWEL DISEASE | $297K | FY2023 | Mar 2023 – Feb 2025 |
| VA/DoDDepartment of Defense | PRECISION DIAGNOSTICS FOR EARLY MELANOMA DETECTION USING SPATIAL BIOLOGY AND AI-GUIDED IMAGE ANALYSIS | $295.7K | FY2022 | Aug 2022 – Jul 2025 |
| Department of Health and Human Services | SINGLE MOLECULE BIOMOLECULAR CONDENSATE ANALYSIS IN NEURONS - PROJECT SUMMARY/ABSTRACT BIOMOLECULAR CONDENSATES (BMCS) DEFINE SMALL MEMBRANELESS CELLULAR COMPARTMENTS THAT SEGREGATE SPECIFIC PROTEINS AND NUCLEIC ACIDS TO GENERATE CELLULAR FUNCTIONS. FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING (FRAP) IS CURRENTLY THE METHOD OF CHOICE TO CHARACTERIZE BMCS IN VITRO AND IN VIVO AND DERIVE THE AVERAGE DIFFUSION AND TRAPPING OF MOLECULES TRAPPED IN THESE CONDENSATES. ALTHOUGH FRAP IS A GOOD WAY TO RETRIEVE THESE IMPORTANT METRICS, IT GREATLY LIMITS OUR UNDERSTANDING OF BMCS NANOSCALE ORGANIZATION AND DYNAMICS IN LIVE CELLS AND PRECLUDES THE ANALYSIS OF NANOSCALE BMCS (BELOW THE DIFFRACTION OF LIGHT ~200 NM). SINGLE-MOLECULE IMAGING SUPER-RESOLUTION MICROSCOPY ALLOWS DIRECT IMAGING OF MOLECULES TRAPPED IN BMCS WITH MUCH GREATER SPATIOTEMPORAL RESOLUTION BOTH IN VITRO AND IN LIVE NEURONS, AND HAS THE POTENTIAL TO REVEAL NANOSCALE BMCS AND THEIR EVOLUTION IN THE CONTEXT OF AGEING AND ALZHEIMER’S DISEASE (AD). HOWEVER, THERE ARE CURRENTLY NO BIOINFORMATIC TOOLS TO SPECIFICALLY ANALYZE BMCS AT THE SINGLE-MOLECULE LEVEL. WE HAVE DEVELOPED A NOVEL TOOL, NAMED NANOSCALE SPATIOTEMPORAL INDEXING CLUSTERING (NASTIC), (WALLIS ET AL., BIORXIV, 2021, REF. 7), WHICH OFFERS UNPRECEDENTED INSIGHTS INTO THE DYNAMICS OF PROTEINS UNDERGOING LIQUID-LIQUID PHASE SEPARATION/TRANSITION IN LARGE AND NANOSCALE BMCS, IN LIVE NEURONS. WE IDENTIFIED TAU AND SYNUCLEIN AS CANDIDATES FOR THEIR ABILITY TO GENERATE SYNAPTIC BMCS IN HIPPOCAMPAL NEURONS. NASTIC ANALYSIS REVEALS THAT TAU MOLECULES CAN INDEED FORM SMALL NANOCLUSTERS IN LIVE HIPPOCAMPAL NEURONS IN WHICH THEY EXHIBIT VERY LOW MOBILITY AND SENSITIVITY TO 1,6-HEXANEDIOL, AN ALIPHATIC ALCOHOL USED TO INHIBIT WEAK MOLECULAR INTERACTIONS THAT MEDIATE BMCS. NASTIC WILL BE AT THE CORE OF OUR ABILITY TO MAKE A SIGNIFICANT CONTRIBUTION TO THE UNDERSTANDING OF BMCS IN NEURONS BECAUSE IT OFFERS UNPRECEDENTED OPPORTUNITIES TO EXAMINE THE SPATIOTEMPORAL BEHAVIOUR OF MOLECULES IN THESE CONDENSATES. NASTIC WILL BE DEVELOPED FURTHER TO ENCOMPASS TWO-COLOR SINGLE-MOLECULE ANALYSIS. THIS WILL BE INSTRUMENTAL TO ASSESS THE SPATIOTEMPORAL RELATIONSHIP OF THESE NANOSCALE BMCS WITH THEIR CELLULAR ENVIRONMENT IN 2 AND 3D. WE WILL VALIDATE OUR TWO-COLOR NASTIC IMPLEMENTATION WITH THE PAIRWISE DUAL IMAGING OF TAU WILDTYPE AND AD MUTANT P301L, AND A-SYNUCLEIN. THIS WILL ALLOW US TO DECIPHER THE CO-CLUSTERING DYNAMICS AND EXAMINE POTENTIAL HIERARCHICAL DEPENDENCY OF ONE NANOBMC UPON THE OTHER ALLOWING REFINED UNDERSTANDING OF THE GENERATION OF NANOSCALE BMCS IN SYNAPSES. WE ANTICIPATE THAT THE P301L MUTATION WILL LARGELY INCREASE THE SIZE AND LIFETIME OF THE TAU NANOBMCS AND ALTER THEIR RELATIONSHIP WITH OTHER SYNAPTIC MOLECULES. THE OUTCOME OF THIS GRANT WILL BE THE DEVELOPMENT AND VALIDATION OF AN ANALYTICAL PIPELINE THAT WILL ENABLE EXPLORATION OF THE SPATIOTEMPORAL RELATIONSHIP OF TAU AND A-SYNUCLEIN NANOBMCS IN LIVE HIPPOCAMPAL NEURONS. OUR PROJECT WILL THEREFORE GENERATE DATA AND A MUCH-NEEDED TECHNOLOGY OPENING NEW AVENUES FOR OUR UNDERSTANDING OF BMCS IN NEURONAL FUNCTION AND AD. | $291.9K | FY2023 | Feb 2023 – Jan 2025 |
| Department of Health and Human Services | EXPLORING THE EFFECT OF HUMAN BLOOD MICRORNAS ON MOSQUITO BIOLOGY | $290.3K | FY2019 | Jul 2019 – Dec 2022 |
| Department of Health and Human Services | DISCOVERY OF POLYMYXIN-BASED ANTIBACTERIAL AGENTS ACTIVE AGAINST MULTI-DRUG RESIS | $290.2K | FY2012 | May 2012 – Apr 2014 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS BASIC RESEARCH FOR AOARD PROPOSAL 16IOA026 "BIO-INSPIRED PERIPERSONAL SPACE SENSORS FOR SOCIAL INTERACTION" | $289.9K | FY2016 | Jul 2016 – Jun 2018 |
| VA/DoDDepartment of Defense | USING A NOVEL HUMANIZED MOUSE MODEL TO INVESTIGATE HOW EBV INFECTION AT DIFFERENT AGES POTENTIATES DEVELOPMENT OF CNS DEMYELINATING DISEASE | $249.2K | FY2024 | Aug 2024 – Aug 2026 |
| VA/DoDDepartment of Defense | DESIGNER ARTIFICIAL CELLS: CUSTOMIZED CELL MEMBRANE-COATED POROUS NANOPARTICLES FOR TARGETING LETHAL CYTOKINE STORM | $243K | FY2021 | May 2021 – Dec 2023 |
| VA/DoDDepartment of Defense | INVESTIGATION OF ABLATION PRODUCTS IN THE NEAR WAKE OF A HIGH-SPEED HYPERSONIC VEHICLE | $241.1K | FY2025 | Sep 2025 – Sep 2028 |
| VA/DoDDepartment of Defense | IMAGAING THE LIVING ACTIVITY OF CELLS | $225.2K | FY2022 | Dec 2021 – Nov 2025 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD PROPOSAL 22IOA049 "PROTECTING SUPERCONDUCTING QUBITS FROM QUASIPARTICLE GENERATED BY COSMIC RAYS", DATED 24 MAR 2022 (THE GRA | $224K | FY2022 | Sep 2022 – Aug 2026 |
| VA/DoDDepartment of Defense | MOLECULAR TARGETS IN ENDOVASCULAR PROGENITORS TO INHIBIT LUNG AND SKIN FIBROSIS IN SCLERODERMA | $219.6K | FY2020 | Mar 2020 – Feb 2022 |
| VA/DoDDepartment of Defense | EXPERIMENTAL VALIDATION OF THE MMT THERMOCHEMICAL NONEQUILIBRIUM AIR CHEMISTRY MODEL IN THE X2 FREE-PISTON DRIVEN EXPANSION TUBE | $214.5K | FY2025 | Sep 2025 – Sep 2026 |
| VA/DoDDepartment of Defense | IDENTIFYING ANTIGEN-SPECIFIC T AND B CELLS IN SERONEGATIVE RHEUMATOID ARTHRITIS SYNOVIAL TISSUE: IMPLICATIONS FOR ANTIGEN-SPECIFIC IMMUNOTHERAPY | $212.6K | FY2020 | Feb 2020 – Feb 2023 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS AOARD PROPOSAL 16IOA057 "RAPIDLY EXPANDING NON EQUILIBRIUM HYPERSONIC FLOW", DATED 15 MAR 2016 (THE GRANTEE'S TECHNICAL PROPOSAL) I | $210K | FY2016 | Sep 2016 – Sep 2018 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS AOARD 15IOA093 "MACH 6-8 SCRAMJET COMBUSTION EXPERIMENTS USING HYDROCARBON FUEL" DATED 17 DEC 2014 (THE | $196K | FY2015 | Sep 2015 – Sep 2017 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS 'EXAMINING GROWTH OF TURBULENCE OVER HEATED WALLS IN HYPERSONIC FLOWS'. | $187K | FY2018 | Jul 2018 – Jan 2022 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS COMPUTATIONAL COMPLEXITY OF BOSONS IN LINEAR NETWORKS, | $180K | FY2013 | May 2013 – May 2016 |
| VA/DoDDepartment of Defense | COMPARATIVE EFFECTIVENESS OF EXERCISE, COGNITIVE BEHAVIORAL THERAPY, AND THEIR COMBINATION FOR PEOPLE WITH CHRONIC MUSCULOSKELETAL PAIN AND POOR SLEEP | $170.7K | FY2024 | Sep 2024 – Sep 2028 |
| VA/DoDDepartment of Defense | INVESTIGATING THE INNER-MAGNETOSPHERE HOT ZONE AND THE MAGNETOSPHERE-IONOSPHERE (M-I) CONJUGATE SUBAURORAL FLOWS | $169.9K | FY2023 | Jun 2023 – Dec 2026 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD 114030 "NATURAL MODELS FOR AUTONOMOUS CONTROL OF SPATIAL NAVIGATION, SENSING, AND GUIDANCE, DATED 24 FEB 11" (THE GRANTEE'S | $169K | FY2011 | Apr 2011 – Apr 2012 |
| VA/DoDDepartment of Defense | INVENTION OF A GENETIC TOOLKIT FOR IMMUNOMODULATORY GUT BACTERIA TO EXPEDITE THE DEVELOPMENT OF NEW CROHN'S DISEASE THERAPEUTICS | $165.2K | FY2017 | Jun 2017 – Dec 2019 |
| VA/DoDDepartment of Defense | GROUND-TESTS FOR DEVELOPMENT OF SINGLE-STAGE ACCESS-TO-SPACE PROPULSION SYSTEMS | $150K | FY2025 | Sep 2025 – Sep 2029 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD PROPOSAL 20IOA087 "CLEAN AND TUNABLE PHASE SLIP QUBIT", DATED 22 SEP 2020 (THE GRANTEE'S TECHNICAL PROPOSAL) IS HEREBY INCORP | $150K | FY2021 | Mar 2021 – Mar 2023 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD PROPOSAL 20IOA006 "INTRODUCING THE SUPERCONDUCTING SADDLE POINT QUBIT", DATED 4 NOV 19 (THE GRANTEE'S TECHNICAL PROPOSAL) I | $150K | FY2020 | Feb 2020 – Feb 2022 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD 124052 "REBUILDING GOVERNMENT LEGITIMACY IN POST-CONFLICT SOCIETIES: CASE STUDIES OF NEPAL AND AFGHANISTAN, DATED 25 MAY 11" | $150K | FY2013 | Mar 2013 – Mar 2014 |
| Department of Commerce | THERMOMETRY AT THE DOUBLE SHOT-NOISE LIMIT | $150K | FY2013 | Oct 2012 – Sep 2015 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS BASIC RESEARCH FOR AOARD "HUMAN-ROBOT INTERACTIONS: SOCIAL MICRO-ABILITIES TO ESTABLISH AND MANAGE SOCIAL EXCHANGE"" | $149.9K | FY2015 | Sep 2015 – Sep 2016 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD 134060 "COMPARISON BETWEEN HYDROGEN AND METHANE FUELS IN A 3-D SCRAMJET AT MACH 8, DATED 16 NOV 12" (THE GRANTEE'S TECHNICAL | $144K | FY2013 | Mar 2013 – Mar 2015 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS 'STUDY OF NON-EQUILIBRIUM WAKES MODEL' | $140K | FY2019 | Feb 2019 – Feb 2022 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS 'ENABLING QUANTUM INFORMATION TECHNOLOGY WITH 60 PHOTONS AND BEYOND' | $120K | FY2019 | Apr 2019 – Apr 2021 |
| VA/DoDDepartment of Defense | NICOP - BIO-INSPIRATION FROM A 400 MILLION-YEAR-OLD ARMS-RACE: STOMATOPODS V CEPHALOPODS AND THE FIGHT FOR VISUAL SYSTEM DOMINANCE | $119.6K | FY2018 | Jul 2018 – Jul 2021 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS AOARD PROPOSAL 17IOA007 "DISCOVERING PATTERNS IN HUMAN-ROBOT INTERACTION: NEW TOOLS FOR COMPLEX ADAPTIVE SOCIAL SYSTEMS", DATED 15 | $115K | FY2017 | Jan 2017 – Jan 2018 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS BASIC RESEARCH FOR AOARD PROPOSAL 17IOA005 'DESIGN OF POLYMERS FOR 3D PRINTING VIA NON-EQUILIBRIUM MOLECULAR DYNAMICS SIMULATION' | $114.9K | FY2017 | Jun 2017 – May 2019 |
| VA/DoDDepartment of Defense | TAS::573600::XXX "BASIC RESEARCH FOR AOARD 144017 "COMPOSITE REINFORCEMENT USING BORON NITRIDE NANOTUBES - 2, DATED 25 FEB 14" (THE GRANTEE'S TECHNIC | $100K | FY2014 | Jun 2014 – Jun 2016 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD 104124 "EXPERIMENTAL STUDY OF HYPERSONIC WING/FIN ROOT HEATING AT MACH 8, DATED 10 JUN 10" (THE GRANTEE'S TECHNICAL PROPOSAL | $100K | FY2010 | Jun 2010 – Jun 2012 |
| Department of Commerce | PURPOSE: IMPROVE THE SELECTION OF FINGERPRINT EXAMINERS FOR LAW ENFORCEMENT AGENCIES BY ADAPTING AND EVALUATING A COGNITIVE ASSESSMENT DEPLOYED IN OTHER COUNTRIES.ACTIVITIES TO BE PERFORMED: THE GOALS OF THE PROJECT WILL BE ACHIEVED BY WORKING WITH SUBJECT MATTER EXPERTS TO DEFINE AND IMPLEMENT A STRATEGY FOR SOURCING OR DEVELOPING APPROPRIATE, SECURE, AND OPERATIONALLY RELEVANT FINGERPRINT STIMULI. AFTER MATERIAL DEVELOPMENT THE TEAM WILL WORK ON ADAPTION AND DELIVERY FORMAT OF THE XQ FRAMEWORK, DATA COLLECTION AND ANALYSIS, AND REPORTING ON METHODOLOGY, ADAPTATION PROCESS, DATA ANALYSIS, AND KEY FINDINGS.EXPECTED OUTCOMES: ADAPTION OF THE XQ FRAMEWORK FOR THE US FEDERAL LAW ENFORCEMENT FINGERPRINT EXAMINER WITH DOCUMENTATION WITH SPECIFICATIONS FOR CURATING STIMULUS SETS, TASK INSTRUCTIONS, VALIDATED DELIVERY FORMAT, AND SCORING GUIDELINES.INTENDED BENEFICIARIES: THE FEDERAL BUREAU OF INVESTIGATION LABORATORY DIVISION WOULD BE THE PRIMARY END-USER OF THE ADAPTED TOOL. A DIRECT AND MAJOR IMPACT WILL BE PROVIDING THE FBI WITH AN EVIDENCE BASE THAT CAN HELP THEM IMPROVE EXAMINER SELECTION. IT WILL ALSO BENEFIT FBI PARTNERS IN OTHER FEDERAL, STATE, AND LOCAL LAW ENFORCEMENT FORENSIC SCIENCE LABORATORIES.SUBRECIPIENT ACTIVITIES: THE UNIVERSITY OF ADELAIDE: SIMULUS SELECTION CRITERIA, DEVELOPMENT OF DELIVERY FORMAT, VALIDATION OF DELIVERY FORMATMURDOCH UNIVERSITY: STATISTICAL METHODOLOGY FOR VALIDATION, PERFORMANCE ANALYSIS, DATA INTERPRETATION, PREPARATION OF TECHNICAL REPORTS, ADMINISTRATIVE ASPECTS. | $99K | FY2026 | Oct 2025 – Sep 2027 |
| Department of Health and Human Services | A POPULATION-BASES ATLAS OF THE ZEBRAFISH BRAIN FOR QUANTITATIVE PHENOTYPIC COMPA | $78K | FY2011 | Sep 2011 – Aug 2013 |
| VA/DoDDepartment of Defense | QUANTUM ACCELERATOR EFFICIENT FAST PHOTONIC INTEGRATED CIRCUITS FOR PHOTONIC QUANTUM COMPUTING | $75K | FY2021 | Nov 2020 – Nov 2021 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS AOARD PROPOSAL 17IOA077 'BIO-INSPIRED GPS-FREE NAVIGATION USING MANTIS SHRIMP (STOMATOPOD) VISION', DATED 06 APR 2017 (THE GRANTEE' | $71K | FY2017 | Sep 2017 – Aug 2018 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD PROPOSAL 21IOA103 "INVESTIGATING INSTABILITY MECHANISMS AND THEIR IMPACTS ON THE COUPLED SOLAR WIND-MAGNETOSPHERE-IONOSPHERE | $68K | FY2021 | Sep 2021 – Sep 2023 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD PROPOSAL 19IOA081 "ELECTROMAGNETIC ENERGY DEPOSITION DURING MAGNETOSPHERE-IONOSPHERE-THERMOSPHERE (M-I-T) COUPLING", DATED 24 | $60K | FY2019 | Aug 2019 – Aug 2021 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS AOARD PROPOSAL 17IOA109 'INVESTIGATING IONOSPHERIC HEAT SOURCES AND RESULTANT THERMOSPHERIC RESPONSES', DATED 27 JUN 17 (THE GRANTE | $60K | FY2017 | Sep 2017 – Jan 2020 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS BASIC RESEARCH FOR 15IOA038 "UNLOCKING THE STRUCTURE AND DYNAMICS OF THIN POLYMERIC FILMS" DATED 25 FEB 15. | $57.2K | FY2015 | Jun 2015 – Jul 2015 |
| VA/DoDDepartment of Defense | TAS::573600::XXX "BASIC RESEARCH FOR AOARD 144028 "A UNIQUE MODEL PLATFORM FOR C4 PLANT SYSTEMS AND SYNTHETIC BIOLOGY, DATED 1 MAR 13" (THE GRANTEE'S | $50K | FY2014 | Jun 2014 – Jun 2015 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD 134071 "COMPOSITE REINFORCEMENT USING BORON NITRIDE NANOTUBES, DATED 11 JAN 13" (THE GRANTEE'S TECHNICAL PROPOSAL) AND "THE | $50K | FY2013 | Mar 2013 – Mar 2014 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS QUANTUM DOT SUPERLATTICE ENABLED RATIONAL DESIGN IN OPTOELECTRONICS AND HYDROGEN GENERATION | $40K | FY2013 | Apr 2013 – Apr 2014 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD 104109 "REBUILDING INSTITUTIONAL LEGITIMACY IN POST-CONFLICT SOCIETIES: AN ASIA-PACIFIC CASE STUDY, INTERPHASE 1-2, DATED 13 | $35K | FY2010 | Jul 2010 – Jun 2011 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD 104011 "AFFECTIVE INTENSITY AND ITS EFFECTS, DATED 6 MAR 09" (THE GRANTEE'S TECHNICAL PROPOSAL) AND "THE AFRL GRANTS TERMS A | $30K | FY2010 | Nov 2009 – Nov 2010 |
| VA/DoDDepartment of Defense | NICOP - LARGE SCALE SEQUENTIAL DECISION MAKING IN AN UNCERTAIN WORLD | $25.9K | FY2017 | Sep 2017 – Mar 2019 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS AOARD PROPOSAL 16IOA127 "MULTI-INSTRUMENT INVESTIGATION OF IONOSPHERIC FLOW CHANNELS AND THEIR IMPACT ON THE IONOSPHERE AND THERMOS | $25K | FY2016 | Sep 2016 – Sep 2017 |
| VA/DoDDepartment of Defense | TAS::57 3600::TAS BASIC RESEARCH FOR15IOA043 "SUB-AURORAL POLARIZATION STREAM ELECTRIC FIELD IN COUPLED MIT PROCESSES" DATED 18 FEB 2015. | $25K | FY2015 | Jun 2015 – May 2016 |
| VA/DoDDepartment of Defense | TAS::573600::XXX "BASIC RESEARCH FOR AOARD 144077 "INVESTIGATING PERTURBATION ELECTRIC FIELDS AND THEIR EFFECTS ON THE COUPLED LOW-, MID- AND HIGH-LA | $25K | FY2014 | May 2014 – Aug 2015 |
| VA/DoDDepartment of Defense | VALUE OF INFORMATION THEORY TO IMPROVE THE MANAGEMENT OF BIOLOGICAL POPULATIONS BIOMATHEMATICS | $20.1K | FY2025 | Oct 2024 – Sep 2025 |
| VA/DoDDepartment of Defense | BASIC RESEARCH FOR AOARD 134090 "INVESTIGATING REPEATABLE IONOSPHERIC FEATURES DURING LARGE SPACE STORMS AND SUPERSTORMS, DATED 26 DEC 12" (THE GRANT | $20K | FY2013 | Mar 2013 – Jan 2014 |
| VA/DoDDepartment of Defense | CSP FOR AOARD PROPOSAL 23IOA002 "PRECISION AND QUANTUM SENSING (PQS)", DATED 11 AUG 2022 (THE GRANTEE'S TECHNICAL PROPOSAL) IS HEREBY INCORPORATED BY | $17.3K | FY2023 | Dec 2022 – Mar 2023 |
| VA/DoDDepartment of Defense | REFRAMING POLICY DEVELOPMENT IN POLAR REGIONS: COOPERATION, NOT CONFLICT | $15K | FY2015 | May 2015 – Oct 2015 |
| VA/DoDDepartment of Defense | DEVELOPING AND FUNDING SYNBIO RESEARCH IN AUSTRALIA | $5,000 | FY2014 | Jul 2014 – Jul 2015 |
| VA/DoDDepartment of Defense | SOCIAL COMPUTING AND CRISIS IN THE NEW INFORMATION AGE | $5,000 | FY2014 | Nov 2013 – Nov 2013 |
| VA/DoDDepartment of Defense | SOLVING A MAJOR COMPLICATION OF PARKINSON'S DISEASE: TARGETING DEBILITATING CONSTIPATION THROUGH NOVEL PHARMACOLOGY | $0 | FY2025 | Apr 2025 – Apr 2028 |
Department of Defense
$2.4M
NEXT-GENERATION PEPTIDE-BASED MEDICINES FOR MALARIA
Department of Health and Human Services
$1.9M
HUMAN-INFORMED DATA-DRIVEN DEVELOPMENT OF NEXT-GENERATION T CELL VACCINE AGAINST MALARIA - PA-19-077 DOOLAN: PROJECT SUMMARY MALARIA REMAINS A GLOBAL PUBLIC HEALTH PROBLEM WITH NEARLY HALF OF THE WORLD'S POPULATION AT RISK. AN EFFECTIVE MALARIA VACCINE WOULD PREVENT ALMOST HALF A MILLION DEATHS AND OVER 200 MILLION CLINICAL CASES EACH YEAR AND HELP ERADICATE THE DISEASE. THE MOST EFFECTIVE EXPERIMENTAL MALARIA VACCINATION REGIMENS TO DATE ARE RADIATION- ATTENUATED SPOROZOITES (RAS; PFSPZ) AND INFECTIOUS SPOROZOITES ADMINISTERED UNDER CHEMOPROPHYLAXIS (CPS). PROTECTIVE IMMUNITY IS BELIEVED TO BE MEDIATED BY CD8+ T CELLS WHICH ATTACK THE PARASITE DURING THE PRE- ERYTHROCYTIC (PE) LIVER-STAGE OF INFECTION. HOWEVER, THE KEY ANTIGENS UNDERLYING THIS PROTECTION ARE LARGELY UNKNOWN. WE HAVE DEVELOPED AND APPLIED A PROTEOME-WIDE T CELL SCREENING APPROACH TO IDENTIFY THE SUBSET OF KEY ANTIGENS TARGETED BY T CELL RESPONSES FROM THE COMPLETE PLASMODIUM FALCIPARUM PARASITE PROTEOME. WE HAVE SHOWN THAT THE ANTIGENS PREFERENTIALLY RECOGNIZED BY T CELLS ARE DISTINCT FROM ANTIBODY TARGETS. HERE, WE WILL CHARACTERIZE AND CREDENTIAL HIGHLY RANKED PRE-ERYTHROCYTIC P. FALCIPARUM T CELL ANTIGENS FROM OUR UNIQUE DATASET, FOCUSING ON THOSE THAT ARE CATEGORIZED AS EXCLUSIVELY T CELL TARGETS, SINCE T CELLS DIRECTED AGAINST LIVER- STAGE ANTIGENS ARE CONSIDERED THE PRIMARY IMMUNE EFFECTORS REQUIRED FOR STERILE IMMUNITY AGAINST MALARIA WHICH PREVENTS DISEASE AND STOPS TRANSMISSION. OUR SELECTION CRITERIA WILL CONSIDER EXTENT OF SEQUENCE CONSERVATION ACROSS PLASMODIUM STRAINS AND SPECIES, TO TARGET A VACCINE THAT CONFERS STRAIN TRANSCENDING AND CROSS-SPECIES PROTECTION. WE WILL USE CLINICALLY RELEVANT SELECTION CRITERIA GOVERNED BY THE CAPACITY OF THE ANTIGEN TO PROTECT AGAINST VIRULENT P. YOELII PARASITE CHALLENGE IN ESTABLISHED PRECLINICAL MODELS AND TO BE RECOGNIZED BY RECALL PLASMODIUM-SPECIFIC IMMUNE RESPONSES IN PROTECTIVE HUMAN MODELS. WE WILL USE TWO INNOVATIVE VACCINE DELIVERY PLATFORMS SELECTED FOR CAPACITY TO INDUCE ROBUST AND SUSTAINED T CELL RESPONSES, WITH A SPECIFIC FOCUS ON THE INDUCTION OF LIVER-SPECIFIC RESIDENT MEMORY T CELLS (TRM) TARGETING THE PUTATIVE SITE OF IMMUNE ACTION. OUR SELECTED REGIMENS INCLUDE “PRIME-TARGET” COMPRISING A DNA PRIME FOLLOWED BY ADENOVIRUS BOOST DELIVERED INTRAVENOUSLY TO TARGET THE LIVER, AND A LIPOSOMAL MRNA VACCINE PLATFORM WITH AN INCORPORATED AGONIST (CA) TO ACTIVATE NKT CELLS AND LINK INNATE AND ADAPTIVE IMMUNITY; BOTH PLATFORMS CAN INDUCE SUSTAINED T CELL RESPONSES AND ARE CAPABLE OF PROTECTING MICE AGAINST SPOROZOITE CHALLENGE. WE WILL ASSIGN PRIORITIES FOR VACCINE DEVELOPMENT ACCORDING TO THEIR CREDENTIALS, EVALUATE COMBINATIONS FOR SYNERGY, AND DOWN-SELECT FOR CLINICAL DEVELOPMENT THE SET OF ANTIGENS THAT HAVE A MAXIMUM LIKELIHOOD OF INDUCING ROBUST AND SUSTAINED PROTECTIVE IMMUNITY AGAINST MALARIA IN HUMANS. THE OPTIMAL VACCINE CANDIDATE DEFINED WITH THIS PRECLINICAL DEVELOPMENT STRATEGY COULD BE TRANSITIONED DIRECTLY TO CLINICAL DEVELOPMENT WITH THE ULTIMATE GOAL OF DEPLOYING IN THE FIELD AN EFFECTIVE RATIONALLY-DESIGNED GENOME-BASED VACCINE THAT WOULD INDUCE DURABLE T-CELL MEDIATED PROTECTION AND AMELIORATE DISEASE IN ALL AT-RISK INDIVIDUALS.
Department of Defense
$1.8M
DRUGS FROM BUGS: DEVELOPING NEW INFLAMMATORY BOWEL DISEASE DRUGS FROM GUT BACTERIA-DERIVED BIOACTIVES
Department of Health and Human Services
$1.7M
WHAT CAUSES LOW BACK PAIN TO FLARE: HAS A MAJOR OPPORTUNITY TO UNDERSTAND BACK PAIN BEEN MISSED? - PROJECT SUMMARY/ABSTRACT LOW BACK PAIN (LBP) IS TRADITIONALLY VIEWED AS EITHER A TRANSIENT CONDITION WITH ACUTE EPISODES OR A CHRONIC PERSISTING CONDITION. HOWEVER, IT IS INCREASINGLY RECOGNIZED THAT FOR MOST (>80% OF CASES), LBP HAS A VARIABLE AND ONGOING TRAJECTORY CHARACTERIZED BY FLUCTUATING SYMPTOMS – WITH PERIODS OF WORSE SYMPTOMS REFERRED TO AS “FLARES”. CURRENT WORK REGARDING RISK FACTORS FOR LBP ONLY CONSIDERS THOSE ASSOCIATED WITH A NEW EPISODE OR THE TRANSITION TO CHRONIC LBP. FINDINGS FROM THAT WORK HAS FAILED TO DELIVER EFFECTIVE STRATEGIES TO PREVENT NEW EPISODES OR CHRONICITY, NOR REDUCE THE EXCESSIVE BURDEN OF LBP. THE UNDERLYING PREMISE OF THIS PROPOSAL IS THAT FLUCTUATION OR FLARING OF LBP IS MEDIATED BY TRANSIENT/FLUCTUATING EXPOSURE TO A RANGE OF FACTORS ACROSS MULTIPLE DOMAINS, THAT DIFFER BETWEEN INDIVIDUALS, AND IDENTIFICATION OF THESE FACTORS COULD PROVIDE A BASIS FOR A COMPLETELY NEW MODEL TO PERSONALIZE CARE. THIS PROJECT WILL TAKE A FRESH LOOK AT LBP BY DIRECTLY ADDRESSING THIS QUESTION USING INNOVATIVE METHODS THAT ARE ENABLED BY RECENT ADVANCES IN TECHNOLOGY. THE WORK IS BASED ON OUR EXTENSIVE COLLABORATION WITH PEOPLE WITH LBP THAT HAS PROVIDED CRITICAL INSIGHT INTO HOW FLARES ARE DEFINED (WHICH SURPRISINGLY IS NOT BASED ON PAIN ALONE) AND THEIR PERSPECTIVE OF THE POTENTIAL CAUSES FOR LBP FLARES. OUR MULTIDISCIPLINARY RESEARCH TEAM PROPOSE AN INNOVATIVE CASE-CROSSOVER STUDY THAT WILL ADDRESS TWO AIMS. AIM 1 WILL EXAMINE, AT MULTIPLE TIMEPOINTS OVER A PERIOD OF 3 MONTHS, AN ARRAY OF CANDIDATE BIOLOGICAL/BEHAVIORAL, PSYCHOLOGICAL, SOCIAL, AND ENVIRONMENTAL RISK FACTORS FOR LBP FLARE THAT HAVE BEEN SELECTED BASED ON CONSUMER PERSPECTIVE, LITERATURE REVIEW AND OUR EXTENSIVE PRELIMINARY STUDIES. MEASURES WILL BE MADE IN THE “REAL WORD” USING ADVANCED WEARABLE AND ONLINE TECHNOLOGIES. AIM 2 WILL INVOLVE AN EMBEDDED STUDY OF INDIVIDUALS FROM THE MAIN PARTICIPANT COHORT WHO FLARE FREQUENTLY. FOR 7 DAYS, ELIGIBLE INDIVIDUALS WILL UNDERGO MORE INTENSIVE “REAL- WORLD” PHYSIOLOGICAL AND BIOMECHANICAL MEASURES USING AN INNOVATIVE COMBINATION OF WEARABLE SENSORS AND HOME-BASED SAMPLE/DATA COLLECTION TO INVESTIGATE POTENTIAL MECHANISMS UNDERLYING TWO SURPRISING PRELIMINARY OBSERVATIONS: (1) THAT POOR SLEEP IS A POTENT RISK FACTOR FOR A SUBSEQUENT FLARE (AS OPPOSED TO THE TRADITIONAL VIEW THAT PAIN INTERFERES WITH AND CAUSES POOR SLEEP), AND (2) THAT LOW RATHER THAN HIGH PHYSICAL ACTIVITY IS A RISK FACTOR FOR LBP FLARE. WE AIMS TO IDENTIFY NOT ONLY IF, BUT HOW, DAILY VARIATIONS IN SLEEP QUALITY AND PHYSICAL ACTIVITY – TWO OF THE MOST IMPORTANT, YET MODIFIABLE HEALTH BEHAVIORS – DRIVE FLARE OF LBP. TOGETHER THESE DATA WILL FILL A MAJOR GAP BY PROVIDING NEW UNDERSTANDING OF MECHANISMS THAT DRIVE THE FLUCTUATING EXPERIENCE OF LBP. SUCH FACTORS WILL PROVIDE THE FOUNDATION TO DEVELOP AND TEST MORE TARGETED AND PERSONALIZED INTERVENTIONS TO REDUCE THE ENORMOUS – AND WORSENING – BURDEN OF THIS CONDITION ON SUFFERERS AND SOCIETY.
Department of Defense
$1.5M
DISCOVERY OF NEW TREATMENTS AND BIOMARKERS FOR NEUROGENIC HETEROTOPIC OSSIFICATIONS FOLLOWING SPINAL CORD INJURIES
Department of Defense
$1.4M
PEPTIDE INHIBITORS TARGETING SODIUM CHANNELS TO TREAT AMYOTROPHIC LATERAL SCLEROSIS
Department of Defense
$1.3M
SPINEPASS: SPINE SELF-MANAGEMENT TECHNIQUES FOR PERSISTENT HEADACHE AFTER CONCUSSION-PHYSICAL THERAPY TARGETING AUTONOMIC AND DURA MATER FUNCTION
Department of Health and Human Services
$1.2M
ELUCIDATING SENSORIAL AND FUNCTIONAL CHARACTERISTICS OF TOPICAL FORMULATIONS
Department of Defense
$1.2M
TOPICAL VENOM ACTIVATED HYDROGEL HEMOSTATIC (PROCOAGULANT + ANTIFIBRINOLYTIC) AGENT
Department of Defense
$1.2M
PREDICTING EARLY-STAGE MELANOMA AT HIGH RISK OF RECURRENCE THROUGH MULTIOMICS PROFILING
Department of Defense
$1.1M
A FIRST-IN-CLASS CALCIUM CHANNEL INHIBITOR FOR THE TREATMENT OF ADVANCED METASTATIC PROSTATE CANCERS RESISTANT TO NEXT-GENERATION ANTIANDROGEN THERAPY
Department of Defense
$1.1M
PROTEOMIC BIOMARKERS FOR ALS DISEASE PROGNOSIS AND PROGRESSION MONITORING.
Department of Defense
$1.1M
EXPLOITING THE REMODELING OF CA2+ SIGNALING IN BREAST CANCER CELL MICROENVIRONMENTS TO CONTROL METASTASIS AND TO SPECIFICALLY TARGET BRAIN METASTASES
Department of Defense
$1.1M
PRECLINICAL VALIDATION OF A NOVEL DRUG LEAD TO TREAT TUBERCULOSIS
Department of Defense
$1M
TAS::57 3600::TAS "BASIC RESEARCH FOR AOARD 144046 "QUANTUM MICRORHEOLOGY, DATED 15 JAN 14" (THE GRANTEE'S TECHNICAL PROPOSAL)"
Department of Defense
$1M
UNDERSTANDING ACUTE TO CHRONIC BACK PAIN PATHWAYS AND TESTING NEW SOLUTIONS. NEW AWARD.
Department of Defense
$990.5K
EXPLOITING THE REMODELING OF CA2+ SIGNALING IN BREAST CANCER CELL MICROENVIRONMENTS TO CONTROL METASTASIS AND TO SPECIFICALLY TARGET BRAIN METASTASES
Agency for International Development
$922.4K
RAPID AND NOVEL SURVEILLANCE TOOL FOR DETECTING ARBOVIRUS TRANSMISSION HOTSPOTS IN BRAZIL
Department of Health and Human Services
$919.6K
DISCOVERY OF POLYMYXIN-BASED ANTIBACTERIAL AGENTS ACTIVE AGAINST MULTI-DRUG RESIS
Department of Health and Human Services
$818.4K
MURINE ATLAS OF GENITOURINARY DEVELOPMENT
Department of Defense
$789.4K
ENDOMETRIOSIS SUSCEPTIBILITY GENES IN ENDOMETRIAL STEM/PROGENITOR CELLS
Department of Defense
$763.5K
ENHANCEMENT OF NATURAL KILLER CELL FUNCTION FOR THERAPEUTIC TARGETING AND ELIMINATION OF METASTATIC BREAST CANCER
Department of Defense
$745K
DISCOVERING THERAPEUTIC VULNERABILITIES OF CIRCULATING MELANOMA CLUSTERS
Department of Defense
$744.7K
UNDERSTANDING THE ROLE OF IMMATURE MYELOID CELLS IN EARLY MELANOMA ESTABLISHMENT
Department of Defense
$744.3K
MELANOMA RESEARCH PROGRAM
Department of Defense
$731K
THERAPEUTIC INHIBITION OF NEUTROPHIL ACTIVITY AS A DISEASE-MODIFYING TREATMENT FOR AMYOTROPHIC LATERAL SCLEROSIS
Department of Defense
$727.6K
QUANTUM CONTROL OF BIOMOLECULAR VIBRATIONS
Department of Defense
$705.6K
DANGER SIGNALING, TRAUMATIC BRAIN INJURY, AND EPILEPTOGENESIS.
Department of Defense
$695.6K
DECIPHERING AND INTERCEPTING MESSAGES BETWEEN CANCER CELLS AND CELLS IN THE BREAST CANCER MICROENVIRONMENT: ROLES FOR INTRACELLULAR CALCIUM SIGNALING
Department of Defense
$690.5K
MECHANISMS AND TREATMENTS OF HETEROTOPIC OSSIFICATION FOLLOWING SPINAL CORD INJURIES
Department of Defense
$676.3K
RP-115: A NOVEL BIOMARKER OF ASTROCYTE DYSFUNCTION AND GLUTAMATE DYSREGULATION IN BRAIN AND SPINAL CORD IN ALS
Department of Defense
$672.2K
INVESTIGATING THE INFLUENCE OF TAILORED WALL TEMPERATURE PROFILING ON HYPERSONIC BOUNDARY LAYER TRANSITION
Department of Defense
$633.1K
NEW GRANT
Department of Defense
$631.3K
NONEQUILIBRIUM QUANTUM DYNAMICS IN SUPERFLUID HELIUM
Department of Defense
$618.3K
BASIC RESEARCH FOR AOARD 134134 "RE-ENGINEERING THE STOMATOPOD EYE, NATURE'S MOST COMPREHENSIVE VISUAL SENSOR, DATED 28 MAR 12" (THE GRANTEE'S TECHNI
Department of Defense
$563.7K
PREDICTING EARLY-STAGE MELANOMA AT HIGH RISK OF RECURRENCE THROUGH MULTIOMICS PROFILING
Department of Defense
$545K
TARGETING COMPLEMENT IN POST-TRAUMATIC EPILEPTOGENSIS
Department of Defense
$540K
EXPERIMENTAL STUDY OF NON-EQUILIBRIUM TURBULENCE-CHEMISTRY INTERACTION IN EXTERNAL HYPERSONIC FLOWS
Department of Defense
$530.9K
CLEC9A TARGETING ANTIBODIES AS A NEW IMMUNOTHERAPY FOR PROSTATE CANCER
Department of Defense
$520K
A NOVEL MEDIATOR OF CHOLANGIOCARCINOMA THAT HAS POTENTIAL AS A DIAGNOSTIC AND TREATMENT TARGET
Department of Defense
$519.6K
TARGETING CEP55 IN TRIPLE-NEGATIVE BREAST CANCER
Department of Defense
$506.8K
PREDICTING EARLY-STAGE MELANOMA AT HIGH RISK OF RECURRENCE THROUGH MULTIOMICS PROFILING
Department of Health and Human Services
$500K
FORMULATION DRUG PRODUCT QUALITY ATTRIBUTES IN DERMAL PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELS FOR TOPICAL DERMATOLOGICAL DRUG PRODUCTS AND TRANSDERMAL DELIVERY SYSTEMS
Department of Health and Human Services
$487.1K
ATTENUATED WEST NILE VIRUS VACCINE
Department of Defense
$480.6K
SNAKE VENOM-BASED RAPID WOUND SEALANT
Department of Defense
$466.2K
PROOF-OF-CONCEPT STUDIES FOR A NOVEL IMMUNOTHERAPY FOR TRIPLE-NEGATIVE BREAST CANCER AND COMPANION DIAGNOSTIC
Department of Defense
$450K
BASIC RESEARCH FOR AOARD PROPOSAL 20IOA056 "ADVANCED GROUND TESTING AND SIMULATION OF THE BOUNDARY LAYER TRANSITION (BOLT) FLIGHT EXPERIMENT", DATED 1
Department of Defense
$450K
BASIC RESEARCH FOR AOARD PROPOSAL 20IOA018 "HEATED WALL SUPERSONIC COMBUSTION TESTING OF HYDROCARBONS IN AXISYMMETRIC MODELS IN THE T4/X3R SHOCK TUNNE
Department of Defense
$449.9K
ACHIEVING HIGH SENSITIVITY IN CAVITY OPTOMECHANICAL MAGNETOMETRY
Department of Defense
$434.7K
TAS::57 3600::TAS "SENSOR SCHEDULING AND FUSION FOR CATALOG MAINTENANCE OF RESIDENT SPACE OBJECTS"
Department of Defense
$398.2K
TAS::57 3600::TAS 'QUANTUM MICROSCOPY: REACHING AND SURPASSING THE QUANTUM LIMITS TO BIOLOGICAL IMAGING'
Department of Defense
$382.9K
NICOP - OPTIMIZING COGNITIVE PERFORMANCE BY MIMICKING SLOW-WAVE SLEEP IN THE AWAKE BRAIN.
Department of Defense
$300K
TAS::57 3600::TAS CLUSTER-STATE QUANTUM ERROR-CORRECTION BASED ON ADS/CFT
Department of Defense
$297.4K
CHARACTERIZATION AND VALIDATION OF A NEW MOUSE MODEL OF SPONTANEOUS ENDOMETRIOSIS TO IMPLEMENT TRANSLATION OF BASIC RESEARCH TO THE CLINIC
Department of Defense
$297K
EPITHELIAL TISSUE MECHANICS: A NEW KEY TO RELAPSE IN CHRONIC INFLAMMATORY BOWEL DISEASE
Department of Defense
$295.7K
PRECISION DIAGNOSTICS FOR EARLY MELANOMA DETECTION USING SPATIAL BIOLOGY AND AI-GUIDED IMAGE ANALYSIS
Department of Health and Human Services
$291.9K
SINGLE MOLECULE BIOMOLECULAR CONDENSATE ANALYSIS IN NEURONS - PROJECT SUMMARY/ABSTRACT BIOMOLECULAR CONDENSATES (BMCS) DEFINE SMALL MEMBRANELESS CELLULAR COMPARTMENTS THAT SEGREGATE SPECIFIC PROTEINS AND NUCLEIC ACIDS TO GENERATE CELLULAR FUNCTIONS. FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING (FRAP) IS CURRENTLY THE METHOD OF CHOICE TO CHARACTERIZE BMCS IN VITRO AND IN VIVO AND DERIVE THE AVERAGE DIFFUSION AND TRAPPING OF MOLECULES TRAPPED IN THESE CONDENSATES. ALTHOUGH FRAP IS A GOOD WAY TO RETRIEVE THESE IMPORTANT METRICS, IT GREATLY LIMITS OUR UNDERSTANDING OF BMCS NANOSCALE ORGANIZATION AND DYNAMICS IN LIVE CELLS AND PRECLUDES THE ANALYSIS OF NANOSCALE BMCS (BELOW THE DIFFRACTION OF LIGHT ~200 NM). SINGLE-MOLECULE IMAGING SUPER-RESOLUTION MICROSCOPY ALLOWS DIRECT IMAGING OF MOLECULES TRAPPED IN BMCS WITH MUCH GREATER SPATIOTEMPORAL RESOLUTION BOTH IN VITRO AND IN LIVE NEURONS, AND HAS THE POTENTIAL TO REVEAL NANOSCALE BMCS AND THEIR EVOLUTION IN THE CONTEXT OF AGEING AND ALZHEIMER’S DISEASE (AD). HOWEVER, THERE ARE CURRENTLY NO BIOINFORMATIC TOOLS TO SPECIFICALLY ANALYZE BMCS AT THE SINGLE-MOLECULE LEVEL. WE HAVE DEVELOPED A NOVEL TOOL, NAMED NANOSCALE SPATIOTEMPORAL INDEXING CLUSTERING (NASTIC), (WALLIS ET AL., BIORXIV, 2021, REF. 7), WHICH OFFERS UNPRECEDENTED INSIGHTS INTO THE DYNAMICS OF PROTEINS UNDERGOING LIQUID-LIQUID PHASE SEPARATION/TRANSITION IN LARGE AND NANOSCALE BMCS, IN LIVE NEURONS. WE IDENTIFIED TAU AND SYNUCLEIN AS CANDIDATES FOR THEIR ABILITY TO GENERATE SYNAPTIC BMCS IN HIPPOCAMPAL NEURONS. NASTIC ANALYSIS REVEALS THAT TAU MOLECULES CAN INDEED FORM SMALL NANOCLUSTERS IN LIVE HIPPOCAMPAL NEURONS IN WHICH THEY EXHIBIT VERY LOW MOBILITY AND SENSITIVITY TO 1,6-HEXANEDIOL, AN ALIPHATIC ALCOHOL USED TO INHIBIT WEAK MOLECULAR INTERACTIONS THAT MEDIATE BMCS. NASTIC WILL BE AT THE CORE OF OUR ABILITY TO MAKE A SIGNIFICANT CONTRIBUTION TO THE UNDERSTANDING OF BMCS IN NEURONS BECAUSE IT OFFERS UNPRECEDENTED OPPORTUNITIES TO EXAMINE THE SPATIOTEMPORAL BEHAVIOUR OF MOLECULES IN THESE CONDENSATES. NASTIC WILL BE DEVELOPED FURTHER TO ENCOMPASS TWO-COLOR SINGLE-MOLECULE ANALYSIS. THIS WILL BE INSTRUMENTAL TO ASSESS THE SPATIOTEMPORAL RELATIONSHIP OF THESE NANOSCALE BMCS WITH THEIR CELLULAR ENVIRONMENT IN 2 AND 3D. WE WILL VALIDATE OUR TWO-COLOR NASTIC IMPLEMENTATION WITH THE PAIRWISE DUAL IMAGING OF TAU WILDTYPE AND AD MUTANT P301L, AND A-SYNUCLEIN. THIS WILL ALLOW US TO DECIPHER THE CO-CLUSTERING DYNAMICS AND EXAMINE POTENTIAL HIERARCHICAL DEPENDENCY OF ONE NANOBMC UPON THE OTHER ALLOWING REFINED UNDERSTANDING OF THE GENERATION OF NANOSCALE BMCS IN SYNAPSES. WE ANTICIPATE THAT THE P301L MUTATION WILL LARGELY INCREASE THE SIZE AND LIFETIME OF THE TAU NANOBMCS AND ALTER THEIR RELATIONSHIP WITH OTHER SYNAPTIC MOLECULES. THE OUTCOME OF THIS GRANT WILL BE THE DEVELOPMENT AND VALIDATION OF AN ANALYTICAL PIPELINE THAT WILL ENABLE EXPLORATION OF THE SPATIOTEMPORAL RELATIONSHIP OF TAU AND A-SYNUCLEIN NANOBMCS IN LIVE HIPPOCAMPAL NEURONS. OUR PROJECT WILL THEREFORE GENERATE DATA AND A MUCH-NEEDED TECHNOLOGY OPENING NEW AVENUES FOR OUR UNDERSTANDING OF BMCS IN NEURONAL FUNCTION AND AD.
Department of Health and Human Services
$290.3K
EXPLORING THE EFFECT OF HUMAN BLOOD MICRORNAS ON MOSQUITO BIOLOGY
Department of Health and Human Services
$290.2K
DISCOVERY OF POLYMYXIN-BASED ANTIBACTERIAL AGENTS ACTIVE AGAINST MULTI-DRUG RESIS
Department of Defense
$289.9K
TAS::57 3600::TAS BASIC RESEARCH FOR AOARD PROPOSAL 16IOA026 "BIO-INSPIRED PERIPERSONAL SPACE SENSORS FOR SOCIAL INTERACTION"
Department of Defense
$249.2K
USING A NOVEL HUMANIZED MOUSE MODEL TO INVESTIGATE HOW EBV INFECTION AT DIFFERENT AGES POTENTIATES DEVELOPMENT OF CNS DEMYELINATING DISEASE
Department of Defense
$243K
DESIGNER ARTIFICIAL CELLS: CUSTOMIZED CELL MEMBRANE-COATED POROUS NANOPARTICLES FOR TARGETING LETHAL CYTOKINE STORM
Department of Defense
$241.1K
INVESTIGATION OF ABLATION PRODUCTS IN THE NEAR WAKE OF A HIGH-SPEED HYPERSONIC VEHICLE
Department of Defense
$225.2K
IMAGAING THE LIVING ACTIVITY OF CELLS
Department of Defense
$224K
BASIC RESEARCH FOR AOARD PROPOSAL 22IOA049 "PROTECTING SUPERCONDUCTING QUBITS FROM QUASIPARTICLE GENERATED BY COSMIC RAYS", DATED 24 MAR 2022 (THE GRA
Department of Defense
$219.6K
MOLECULAR TARGETS IN ENDOVASCULAR PROGENITORS TO INHIBIT LUNG AND SKIN FIBROSIS IN SCLERODERMA
Department of Defense
$214.5K
EXPERIMENTAL VALIDATION OF THE MMT THERMOCHEMICAL NONEQUILIBRIUM AIR CHEMISTRY MODEL IN THE X2 FREE-PISTON DRIVEN EXPANSION TUBE
Department of Defense
$212.6K
IDENTIFYING ANTIGEN-SPECIFIC T AND B CELLS IN SERONEGATIVE RHEUMATOID ARTHRITIS SYNOVIAL TISSUE: IMPLICATIONS FOR ANTIGEN-SPECIFIC IMMUNOTHERAPY
Department of Defense
$210K
TAS::57 3600::TAS AOARD PROPOSAL 16IOA057 "RAPIDLY EXPANDING NON EQUILIBRIUM HYPERSONIC FLOW", DATED 15 MAR 2016 (THE GRANTEE'S TECHNICAL PROPOSAL) I
Department of Defense
$196K
TAS::57 3600::TAS AOARD 15IOA093 "MACH 6-8 SCRAMJET COMBUSTION EXPERIMENTS USING HYDROCARBON FUEL" DATED 17 DEC 2014 (THE
Department of Defense
$187K
TAS::57 3600::TAS 'EXAMINING GROWTH OF TURBULENCE OVER HEATED WALLS IN HYPERSONIC FLOWS'.
Department of Defense
$180K
TAS::57 3600::TAS COMPUTATIONAL COMPLEXITY OF BOSONS IN LINEAR NETWORKS,
Department of Defense
$170.7K
COMPARATIVE EFFECTIVENESS OF EXERCISE, COGNITIVE BEHAVIORAL THERAPY, AND THEIR COMBINATION FOR PEOPLE WITH CHRONIC MUSCULOSKELETAL PAIN AND POOR SLEEP
Department of Defense
$169.9K
INVESTIGATING THE INNER-MAGNETOSPHERE HOT ZONE AND THE MAGNETOSPHERE-IONOSPHERE (M-I) CONJUGATE SUBAURORAL FLOWS
Department of Defense
$169K
BASIC RESEARCH FOR AOARD 114030 "NATURAL MODELS FOR AUTONOMOUS CONTROL OF SPATIAL NAVIGATION, SENSING, AND GUIDANCE, DATED 24 FEB 11" (THE GRANTEE'S
Department of Defense
$165.2K
INVENTION OF A GENETIC TOOLKIT FOR IMMUNOMODULATORY GUT BACTERIA TO EXPEDITE THE DEVELOPMENT OF NEW CROHN'S DISEASE THERAPEUTICS
Department of Defense
$150K
GROUND-TESTS FOR DEVELOPMENT OF SINGLE-STAGE ACCESS-TO-SPACE PROPULSION SYSTEMS
Department of Defense
$150K
BASIC RESEARCH FOR AOARD PROPOSAL 20IOA087 "CLEAN AND TUNABLE PHASE SLIP QUBIT", DATED 22 SEP 2020 (THE GRANTEE'S TECHNICAL PROPOSAL) IS HEREBY INCORP
Department of Defense
$150K
BASIC RESEARCH FOR AOARD PROPOSAL 20IOA006 "INTRODUCING THE SUPERCONDUCTING SADDLE POINT QUBIT", DATED 4 NOV 19 (THE GRANTEE'S TECHNICAL PROPOSAL) I
Department of Defense
$150K
BASIC RESEARCH FOR AOARD 124052 "REBUILDING GOVERNMENT LEGITIMACY IN POST-CONFLICT SOCIETIES: CASE STUDIES OF NEPAL AND AFGHANISTAN, DATED 25 MAY 11"
Department of Commerce
$150K
THERMOMETRY AT THE DOUBLE SHOT-NOISE LIMIT
Department of Defense
$149.9K
TAS::57 3600::TAS BASIC RESEARCH FOR AOARD "HUMAN-ROBOT INTERACTIONS: SOCIAL MICRO-ABILITIES TO ESTABLISH AND MANAGE SOCIAL EXCHANGE""
Department of Defense
$144K
BASIC RESEARCH FOR AOARD 134060 "COMPARISON BETWEEN HYDROGEN AND METHANE FUELS IN A 3-D SCRAMJET AT MACH 8, DATED 16 NOV 12" (THE GRANTEE'S TECHNICAL
Department of Defense
$140K
TAS::57 3600::TAS 'STUDY OF NON-EQUILIBRIUM WAKES MODEL'
Department of Defense
$120K
TAS::57 3600::TAS 'ENABLING QUANTUM INFORMATION TECHNOLOGY WITH 60 PHOTONS AND BEYOND'
Department of Defense
$119.6K
NICOP - BIO-INSPIRATION FROM A 400 MILLION-YEAR-OLD ARMS-RACE: STOMATOPODS V CEPHALOPODS AND THE FIGHT FOR VISUAL SYSTEM DOMINANCE
Department of Defense
$115K
TAS::57 3600::TAS AOARD PROPOSAL 17IOA007 "DISCOVERING PATTERNS IN HUMAN-ROBOT INTERACTION: NEW TOOLS FOR COMPLEX ADAPTIVE SOCIAL SYSTEMS", DATED 15
Department of Defense
$114.9K
TAS::57 3600::TAS BASIC RESEARCH FOR AOARD PROPOSAL 17IOA005 'DESIGN OF POLYMERS FOR 3D PRINTING VIA NON-EQUILIBRIUM MOLECULAR DYNAMICS SIMULATION'
Department of Defense
$100K
TAS::573600::XXX "BASIC RESEARCH FOR AOARD 144017 "COMPOSITE REINFORCEMENT USING BORON NITRIDE NANOTUBES - 2, DATED 25 FEB 14" (THE GRANTEE'S TECHNIC
Department of Defense
$100K
BASIC RESEARCH FOR AOARD 104124 "EXPERIMENTAL STUDY OF HYPERSONIC WING/FIN ROOT HEATING AT MACH 8, DATED 10 JUN 10" (THE GRANTEE'S TECHNICAL PROPOSAL
Department of Commerce
$99K
PURPOSE: IMPROVE THE SELECTION OF FINGERPRINT EXAMINERS FOR LAW ENFORCEMENT AGENCIES BY ADAPTING AND EVALUATING A COGNITIVE ASSESSMENT DEPLOYED IN OTHER COUNTRIES.ACTIVITIES TO BE PERFORMED: THE GOALS OF THE PROJECT WILL BE ACHIEVED BY WORKING WITH SUBJECT MATTER EXPERTS TO DEFINE AND IMPLEMENT A STRATEGY FOR SOURCING OR DEVELOPING APPROPRIATE, SECURE, AND OPERATIONALLY RELEVANT FINGERPRINT STIMULI. AFTER MATERIAL DEVELOPMENT THE TEAM WILL WORK ON ADAPTION AND DELIVERY FORMAT OF THE XQ FRAMEWORK, DATA COLLECTION AND ANALYSIS, AND REPORTING ON METHODOLOGY, ADAPTATION PROCESS, DATA ANALYSIS, AND KEY FINDINGS.EXPECTED OUTCOMES: ADAPTION OF THE XQ FRAMEWORK FOR THE US FEDERAL LAW ENFORCEMENT FINGERPRINT EXAMINER WITH DOCUMENTATION WITH SPECIFICATIONS FOR CURATING STIMULUS SETS, TASK INSTRUCTIONS, VALIDATED DELIVERY FORMAT, AND SCORING GUIDELINES.INTENDED BENEFICIARIES: THE FEDERAL BUREAU OF INVESTIGATION LABORATORY DIVISION WOULD BE THE PRIMARY END-USER OF THE ADAPTED TOOL. A DIRECT AND MAJOR IMPACT WILL BE PROVIDING THE FBI WITH AN EVIDENCE BASE THAT CAN HELP THEM IMPROVE EXAMINER SELECTION. IT WILL ALSO BENEFIT FBI PARTNERS IN OTHER FEDERAL, STATE, AND LOCAL LAW ENFORCEMENT FORENSIC SCIENCE LABORATORIES.SUBRECIPIENT ACTIVITIES: THE UNIVERSITY OF ADELAIDE: SIMULUS SELECTION CRITERIA, DEVELOPMENT OF DELIVERY FORMAT, VALIDATION OF DELIVERY FORMATMURDOCH UNIVERSITY: STATISTICAL METHODOLOGY FOR VALIDATION, PERFORMANCE ANALYSIS, DATA INTERPRETATION, PREPARATION OF TECHNICAL REPORTS, ADMINISTRATIVE ASPECTS.
Department of Health and Human Services
$78K
A POPULATION-BASES ATLAS OF THE ZEBRAFISH BRAIN FOR QUANTITATIVE PHENOTYPIC COMPA
Department of Defense
$75K
QUANTUM ACCELERATOR EFFICIENT FAST PHOTONIC INTEGRATED CIRCUITS FOR PHOTONIC QUANTUM COMPUTING
Department of Defense
$71K
TAS::57 3600::TAS AOARD PROPOSAL 17IOA077 'BIO-INSPIRED GPS-FREE NAVIGATION USING MANTIS SHRIMP (STOMATOPOD) VISION', DATED 06 APR 2017 (THE GRANTEE'
Department of Defense
$68K
BASIC RESEARCH FOR AOARD PROPOSAL 21IOA103 "INVESTIGATING INSTABILITY MECHANISMS AND THEIR IMPACTS ON THE COUPLED SOLAR WIND-MAGNETOSPHERE-IONOSPHERE
Department of Defense
$60K
BASIC RESEARCH FOR AOARD PROPOSAL 19IOA081 "ELECTROMAGNETIC ENERGY DEPOSITION DURING MAGNETOSPHERE-IONOSPHERE-THERMOSPHERE (M-I-T) COUPLING", DATED 24
Department of Defense
$60K
TAS::57 3600::TAS AOARD PROPOSAL 17IOA109 'INVESTIGATING IONOSPHERIC HEAT SOURCES AND RESULTANT THERMOSPHERIC RESPONSES', DATED 27 JUN 17 (THE GRANTE
Department of Defense
$57.2K
TAS::57 3600::TAS BASIC RESEARCH FOR 15IOA038 "UNLOCKING THE STRUCTURE AND DYNAMICS OF THIN POLYMERIC FILMS" DATED 25 FEB 15.
Department of Defense
$50K
TAS::573600::XXX "BASIC RESEARCH FOR AOARD 144028 "A UNIQUE MODEL PLATFORM FOR C4 PLANT SYSTEMS AND SYNTHETIC BIOLOGY, DATED 1 MAR 13" (THE GRANTEE'S
Department of Defense
$50K
BASIC RESEARCH FOR AOARD 134071 "COMPOSITE REINFORCEMENT USING BORON NITRIDE NANOTUBES, DATED 11 JAN 13" (THE GRANTEE'S TECHNICAL PROPOSAL) AND "THE
Department of Defense
$40K
TAS::57 3600::TAS QUANTUM DOT SUPERLATTICE ENABLED RATIONAL DESIGN IN OPTOELECTRONICS AND HYDROGEN GENERATION
Department of Defense
$35K
BASIC RESEARCH FOR AOARD 104109 "REBUILDING INSTITUTIONAL LEGITIMACY IN POST-CONFLICT SOCIETIES: AN ASIA-PACIFIC CASE STUDY, INTERPHASE 1-2, DATED 13
Department of Defense
$30K
BASIC RESEARCH FOR AOARD 104011 "AFFECTIVE INTENSITY AND ITS EFFECTS, DATED 6 MAR 09" (THE GRANTEE'S TECHNICAL PROPOSAL) AND "THE AFRL GRANTS TERMS A
Department of Defense
$25.9K
NICOP - LARGE SCALE SEQUENTIAL DECISION MAKING IN AN UNCERTAIN WORLD
Department of Defense
$25K
TAS::57 3600::TAS AOARD PROPOSAL 16IOA127 "MULTI-INSTRUMENT INVESTIGATION OF IONOSPHERIC FLOW CHANNELS AND THEIR IMPACT ON THE IONOSPHERE AND THERMOS
Department of Defense
$25K
TAS::57 3600::TAS BASIC RESEARCH FOR15IOA043 "SUB-AURORAL POLARIZATION STREAM ELECTRIC FIELD IN COUPLED MIT PROCESSES" DATED 18 FEB 2015.
Department of Defense
$25K
TAS::573600::XXX "BASIC RESEARCH FOR AOARD 144077 "INVESTIGATING PERTURBATION ELECTRIC FIELDS AND THEIR EFFECTS ON THE COUPLED LOW-, MID- AND HIGH-LA
Department of Defense
$20.1K
VALUE OF INFORMATION THEORY TO IMPROVE THE MANAGEMENT OF BIOLOGICAL POPULATIONS BIOMATHEMATICS
Department of Defense
$20K
BASIC RESEARCH FOR AOARD 134090 "INVESTIGATING REPEATABLE IONOSPHERIC FEATURES DURING LARGE SPACE STORMS AND SUPERSTORMS, DATED 26 DEC 12" (THE GRANT
Department of Defense
$17.3K
CSP FOR AOARD PROPOSAL 23IOA002 "PRECISION AND QUANTUM SENSING (PQS)", DATED 11 AUG 2022 (THE GRANTEE'S TECHNICAL PROPOSAL) IS HEREBY INCORPORATED BY
Department of Defense
$15K
REFRAMING POLICY DEVELOPMENT IN POLAR REGIONS: COOPERATION, NOT CONFLICT
Department of Defense
$5,000
DEVELOPING AND FUNDING SYNBIO RESEARCH IN AUSTRALIA
Department of Defense
$5,000
SOCIAL COMPUTING AND CRISIS IN THE NEW INFORMATION AGE
Department of Defense
$0
SOLVING A MAJOR COMPLICATION OF PARKINSON'S DISEASE: TARGETING DEBILITATING CONSTIPATION THROUGH NOVEL PHARMACOLOGY
Source: Federal Audit Clearinghouse (fac.gov)
No federal single audit records found for this organization.
Single audits are required for entities expending $750,000+ in federal awards annually.
Source: IRS e-Filed Form 990
No officer or director compensation data available for this organization.
This data is sourced from IRS Form 990, Part VII. It may not be available if the organization files Form 990-N (e-Postcard) or has not yet been enriched.
Source: IRS Publication 78, Auto-Revocation List & e-Postcard Data
Tax-deductible contributions: Not confirmed
WarningTax-exempt status was revoked on May 15, 2010
Status has NOT been reinstated
Exemption type: 03
Sources: IRS e-Filed Form 990 (XML) & ProPublica Nonprofit Explorer
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| Year | Revenue | Contributions | Expenses | Assets | Net Assets |
|---|---|---|---|---|---|
| 2022 | $1.4B | $749.3M | $1.5B | $4.8B | $3.6B |
| 2021 | $1.6B | $909.8M | $1.5B | $5B | $3.8B |
| 2020 | $1.4B | $746.2M | $1.4B | $4.6B | $3.3B |
| 2019 | $1.5B | $757.2M | $1.5B | $4.2B |
Sources: ProPublica Nonprofit Explorer & IRS e-File Index
Financial data: IRS Form 990 via ProPublica Nonprofit Explorer (Tax Year 2022)
Federal grants: USAspending.gov (live)
Organization info: IRS Business Master File · ProPublica Nonprofit Explorer
Revocation status: IRS Auto-Revocation List
| $3.2B |
| 2019 | 990 | Data | PDF not yet published by IRS |