The University Of Queensland

NEXT-GENERATION PEPTIDE-BASED MEDICINES FOR MALARIA

HUMAN-INFORMED DATA-DRIVEN DEVELOPMENT OF NEXT-GENERATION T CELL VACCINE AGAINST MALARIA - PA-19-077 DOOLAN: PROJECT SUMMARY MALARIA REMAINS A GLOBAL PUBLIC HEALTH PROBLEM WITH NEARLY HALF OF THE WORLD'S POPULATION AT RISK. AN EFFECTIVE MALARIA VACCINE WOULD PREVENT ALMOST HALF A MILLION DEATHS AND OVER 200 MILLION CLINICAL CASES EACH YEAR AND HELP ERADICATE THE DISEASE. THE MOST EFFECTIVE EXPERIMENTAL MALARIA VACCINATION REGIMENS TO DATE ARE RADIATION- ATTENUATED SPOROZOITES (RAS; PFSPZ) AND INFECTIOUS SPOROZOITES ADMINISTERED UNDER CHEMOPROPHYLAXIS (CPS). PROTECTIVE IMMUNITY IS BELIEVED TO BE MEDIATED BY CD8+ T CELLS WHICH ATTACK THE PARASITE DURING THE PRE- ERYTHROCYTIC (PE) LIVER-STAGE OF INFECTION. HOWEVER, THE KEY ANTIGENS UNDERLYING THIS PROTECTION ARE LARGELY UNKNOWN. WE HAVE DEVELOPED AND APPLIED A PROTEOME-WIDE T CELL SCREENING APPROACH TO IDENTIFY THE SUBSET OF KEY ANTIGENS TARGETED BY T CELL RESPONSES FROM THE COMPLETE PLASMODIUM FALCIPARUM PARASITE PROTEOME. WE HAVE SHOWN THAT THE ANTIGENS PREFERENTIALLY RECOGNIZED BY T CELLS ARE DISTINCT FROM ANTIBODY TARGETS. HERE, WE WILL CHARACTERIZE AND CREDENTIAL HIGHLY RANKED PRE-ERYTHROCYTIC P. FALCIPARUM T CELL ANTIGENS FROM OUR UNIQUE DATASET, FOCUSING ON THOSE THAT ARE CATEGORIZED AS EXCLUSIVELY T CELL TARGETS, SINCE T CELLS DIRECTED AGAINST LIVER- STAGE ANTIGENS ARE CONSIDERED THE PRIMARY IMMUNE EFFECTORS REQUIRED FOR STERILE IMMUNITY AGAINST MALARIA WHICH PREVENTS DISEASE AND STOPS TRANSMISSION. OUR SELECTION CRITERIA WILL CONSIDER EXTENT OF SEQUENCE CONSERVATION ACROSS PLASMODIUM STRAINS AND SPECIES, TO TARGET A VACCINE THAT CONFERS STRAIN TRANSCENDING AND CROSS-SPECIES PROTECTION. WE WILL USE CLINICALLY RELEVANT SELECTION CRITERIA GOVERNED BY THE CAPACITY OF THE ANTIGEN TO PROTECT AGAINST VIRULENT P. YOELII PARASITE CHALLENGE IN ESTABLISHED PRECLINICAL MODELS AND TO BE RECOGNIZED BY RECALL PLASMODIUM-SPECIFIC IMMUNE RESPONSES IN PROTECTIVE HUMAN MODELS. WE WILL USE TWO INNOVATIVE VACCINE DELIVERY PLATFORMS SELECTED FOR CAPACITY TO INDUCE ROBUST AND SUSTAINED T CELL RESPONSES, WITH A SPECIFIC FOCUS ON THE INDUCTION OF LIVER-SPECIFIC RESIDENT MEMORY T CELLS (TRM) TARGETING THE PUTATIVE SITE OF IMMUNE ACTION. OUR SELECTED REGIMENS INCLUDE “PRIME-TARGET” COMPRISING A DNA PRIME FOLLOWED BY ADENOVIRUS BOOST DELIVERED INTRAVENOUSLY TO TARGET THE LIVER, AND A LIPOSOMAL MRNA VACCINE PLATFORM WITH AN INCORPORATED AGONIST (CA) TO ACTIVATE NKT CELLS AND LINK INNATE AND ADAPTIVE IMMUNITY; BOTH PLATFORMS CAN INDUCE SUSTAINED T CELL RESPONSES AND ARE CAPABLE OF PROTECTING MICE AGAINST SPOROZOITE CHALLENGE. WE WILL ASSIGN PRIORITIES FOR VACCINE DEVELOPMENT ACCORDING TO THEIR CREDENTIALS, EVALUATE COMBINATIONS FOR SYNERGY, AND DOWN-SELECT FOR CLINICAL DEVELOPMENT THE SET OF ANTIGENS THAT HAVE A MAXIMUM LIKELIHOOD OF INDUCING ROBUST AND SUSTAINED PROTECTIVE IMMUNITY AGAINST MALARIA IN HUMANS. THE OPTIMAL VACCINE CANDIDATE DEFINED WITH THIS PRECLINICAL DEVELOPMENT STRATEGY COULD BE TRANSITIONED DIRECTLY TO CLINICAL DEVELOPMENT WITH THE ULTIMATE GOAL OF DEPLOYING IN THE FIELD AN EFFECTIVE RATIONALLY-DESIGNED GENOME-BASED VACCINE THAT WOULD INDUCE DURABLE T-CELL MEDIATED PROTECTION AND AMELIORATE DISEASE IN ALL AT-RISK INDIVIDUALS.

DRUGS FROM BUGS: DEVELOPING NEW INFLAMMATORY BOWEL DISEASE DRUGS FROM GUT BACTERIA-DERIVED BIOACTIVES

WHAT CAUSES LOW BACK PAIN TO FLARE: HAS A MAJOR OPPORTUNITY TO UNDERSTAND BACK PAIN BEEN MISSED? - PROJECT SUMMARY/ABSTRACT LOW BACK PAIN (LBP) IS TRADITIONALLY VIEWED AS EITHER A TRANSIENT CONDITION WITH ACUTE EPISODES OR A CHRONIC PERSISTING CONDITION. HOWEVER, IT IS INCREASINGLY RECOGNIZED THAT FOR MOST (>80% OF CASES), LBP HAS A VARIABLE AND ONGOING TRAJECTORY CHARACTERIZED BY FLUCTUATING SYMPTOMS – WITH PERIODS OF WORSE SYMPTOMS REFERRED TO AS “FLARES”. CURRENT WORK REGARDING RISK FACTORS FOR LBP ONLY CONSIDERS THOSE ASSOCIATED WITH A NEW EPISODE OR THE TRANSITION TO CHRONIC LBP. FINDINGS FROM THAT WORK HAS FAILED TO DELIVER EFFECTIVE STRATEGIES TO PREVENT NEW EPISODES OR CHRONICITY, NOR REDUCE THE EXCESSIVE BURDEN OF LBP. THE UNDERLYING PREMISE OF THIS PROPOSAL IS THAT FLUCTUATION OR FLARING OF LBP IS MEDIATED BY TRANSIENT/FLUCTUATING EXPOSURE TO A RANGE OF FACTORS ACROSS MULTIPLE DOMAINS, THAT DIFFER BETWEEN INDIVIDUALS, AND IDENTIFICATION OF THESE FACTORS COULD PROVIDE A BASIS FOR A COMPLETELY NEW MODEL TO PERSONALIZE CARE. THIS PROJECT WILL TAKE A FRESH LOOK AT LBP BY DIRECTLY ADDRESSING THIS QUESTION USING INNOVATIVE METHODS THAT ARE ENABLED BY RECENT ADVANCES IN TECHNOLOGY. THE WORK IS BASED ON OUR EXTENSIVE COLLABORATION WITH PEOPLE WITH LBP THAT HAS PROVIDED CRITICAL INSIGHT INTO HOW FLARES ARE DEFINED (WHICH SURPRISINGLY IS NOT BASED ON PAIN ALONE) AND THEIR PERSPECTIVE OF THE POTENTIAL CAUSES FOR LBP FLARES. OUR MULTIDISCIPLINARY RESEARCH TEAM PROPOSE AN INNOVATIVE CASE-CROSSOVER STUDY THAT WILL ADDRESS TWO AIMS. AIM 1 WILL EXAMINE, AT MULTIPLE TIMEPOINTS OVER A PERIOD OF 3 MONTHS, AN ARRAY OF CANDIDATE BIOLOGICAL/BEHAVIORAL, PSYCHOLOGICAL, SOCIAL, AND ENVIRONMENTAL RISK FACTORS FOR LBP FLARE THAT HAVE BEEN SELECTED BASED ON CONSUMER PERSPECTIVE, LITERATURE REVIEW AND OUR EXTENSIVE PRELIMINARY STUDIES. MEASURES WILL BE MADE IN THE “REAL WORD” USING ADVANCED WEARABLE AND ONLINE TECHNOLOGIES. AIM 2 WILL INVOLVE AN EMBEDDED STUDY OF INDIVIDUALS FROM THE MAIN PARTICIPANT COHORT WHO FLARE FREQUENTLY. FOR 7 DAYS, ELIGIBLE INDIVIDUALS WILL UNDERGO MORE INTENSIVE “REAL- WORLD” PHYSIOLOGICAL AND BIOMECHANICAL MEASURES USING AN INNOVATIVE COMBINATION OF WEARABLE SENSORS AND HOME-BASED SAMPLE/DATA COLLECTION TO INVESTIGATE POTENTIAL MECHANISMS UNDERLYING TWO SURPRISING PRELIMINARY OBSERVATIONS: (1) THAT POOR SLEEP IS A POTENT RISK FACTOR FOR A SUBSEQUENT FLARE (AS OPPOSED TO THE TRADITIONAL VIEW THAT PAIN INTERFERES WITH AND CAUSES POOR SLEEP), AND (2) THAT LOW RATHER THAN HIGH PHYSICAL ACTIVITY IS A RISK FACTOR FOR LBP FLARE. WE AIMS TO IDENTIFY NOT ONLY IF, BUT HOW, DAILY VARIATIONS IN SLEEP QUALITY AND PHYSICAL ACTIVITY – TWO OF THE MOST IMPORTANT, YET MODIFIABLE HEALTH BEHAVIORS – DRIVE FLARE OF LBP. TOGETHER THESE DATA WILL FILL A MAJOR GAP BY PROVIDING NEW UNDERSTANDING OF MECHANISMS THAT DRIVE THE FLUCTUATING EXPERIENCE OF LBP. SUCH FACTORS WILL PROVIDE THE FOUNDATION TO DEVELOP AND TEST MORE TARGETED AND PERSONALIZED INTERVENTIONS TO REDUCE THE ENORMOUS – AND WORSENING – BURDEN OF THIS CONDITION ON SUFFERERS AND SOCIETY.

DISCOVERY OF NEW TREATMENTS AND BIOMARKERS FOR NEUROGENIC HETEROTOPIC OSSIFICATIONS FOLLOWING SPINAL CORD INJURIES

PEPTIDE INHIBITORS TARGETING SODIUM CHANNELS TO TREAT AMYOTROPHIC LATERAL SCLEROSIS

SPINEPASS: SPINE SELF-MANAGEMENT TECHNIQUES FOR PERSISTENT HEADACHE AFTER CONCUSSION-PHYSICAL THERAPY TARGETING AUTONOMIC AND DURA MATER FUNCTION

ELUCIDATING SENSORIAL AND FUNCTIONAL CHARACTERISTICS OF TOPICAL FORMULATIONS

TOPICAL VENOM ACTIVATED HYDROGEL HEMOSTATIC (PROCOAGULANT + ANTIFIBRINOLYTIC) AGENT

PREDICTING EARLY-STAGE MELANOMA AT HIGH RISK OF RECURRENCE THROUGH MULTIOMICS PROFILING

A FIRST-IN-CLASS CALCIUM CHANNEL INHIBITOR FOR THE TREATMENT OF ADVANCED METASTATIC PROSTATE CANCERS RESISTANT TO NEXT-GENERATION ANTIANDROGEN THERAPY

PROTEOMIC BIOMARKERS FOR ALS DISEASE PROGNOSIS AND PROGRESSION MONITORING.

EXPLOITING THE REMODELING OF CA2+ SIGNALING IN BREAST CANCER CELL MICROENVIRONMENTS TO CONTROL METASTASIS AND TO SPECIFICALLY TARGET BRAIN METASTASES

PRECLINICAL VALIDATION OF A NOVEL DRUG LEAD TO TREAT TUBERCULOSIS

TAS::57 3600::TAS "BASIC RESEARCH FOR AOARD 144046 "QUANTUM MICRORHEOLOGY, DATED 15 JAN 14" (THE GRANTEE'S TECHNICAL PROPOSAL)"

UNDERSTANDING ACUTE TO CHRONIC BACK PAIN PATHWAYS AND TESTING NEW SOLUTIONS. NEW AWARD.

EXPLOITING THE REMODELING OF CA2+ SIGNALING IN BREAST CANCER CELL MICROENVIRONMENTS TO CONTROL METASTASIS AND TO SPECIFICALLY TARGET BRAIN METASTASES

RAPID AND NOVEL SURVEILLANCE TOOL FOR DETECTING ARBOVIRUS TRANSMISSION HOTSPOTS IN BRAZIL

DISCOVERY OF POLYMYXIN-BASED ANTIBACTERIAL AGENTS ACTIVE AGAINST MULTI-DRUG RESIS

MURINE ATLAS OF GENITOURINARY DEVELOPMENT

ENDOMETRIOSIS SUSCEPTIBILITY GENES IN ENDOMETRIAL STEM/PROGENITOR CELLS

ENHANCEMENT OF NATURAL KILLER CELL FUNCTION FOR THERAPEUTIC TARGETING AND ELIMINATION OF METASTATIC BREAST CANCER

DISCOVERING THERAPEUTIC VULNERABILITIES OF CIRCULATING MELANOMA CLUSTERS

UNDERSTANDING THE ROLE OF IMMATURE MYELOID CELLS IN EARLY MELANOMA ESTABLISHMENT

MELANOMA RESEARCH PROGRAM

THERAPEUTIC INHIBITION OF NEUTROPHIL ACTIVITY AS A DISEASE-MODIFYING TREATMENT FOR AMYOTROPHIC LATERAL SCLEROSIS

QUANTUM CONTROL OF BIOMOLECULAR VIBRATIONS

DANGER SIGNALING, TRAUMATIC BRAIN INJURY, AND EPILEPTOGENESIS.

DECIPHERING AND INTERCEPTING MESSAGES BETWEEN CANCER CELLS AND CELLS IN THE BREAST CANCER MICROENVIRONMENT: ROLES FOR INTRACELLULAR CALCIUM SIGNALING

MECHANISMS AND TREATMENTS OF HETEROTOPIC OSSIFICATION FOLLOWING SPINAL CORD INJURIES

RP-115: A NOVEL BIOMARKER OF ASTROCYTE DYSFUNCTION AND GLUTAMATE DYSREGULATION IN BRAIN AND SPINAL CORD IN ALS

INVESTIGATING THE INFLUENCE OF TAILORED WALL TEMPERATURE PROFILING ON HYPERSONIC BOUNDARY LAYER TRANSITION

NEW GRANT

NONEQUILIBRIUM QUANTUM DYNAMICS IN SUPERFLUID HELIUM

BASIC RESEARCH FOR AOARD 134134 "RE-ENGINEERING THE STOMATOPOD EYE, NATURE'S MOST COMPREHENSIVE VISUAL SENSOR, DATED 28 MAR 12" (THE GRANTEE'S TECHNI

PREDICTING EARLY-STAGE MELANOMA AT HIGH RISK OF RECURRENCE THROUGH MULTIOMICS PROFILING

TARGETING COMPLEMENT IN POST-TRAUMATIC EPILEPTOGENSIS

EXPERIMENTAL STUDY OF NON-EQUILIBRIUM TURBULENCE-CHEMISTRY INTERACTION IN EXTERNAL HYPERSONIC FLOWS

CLEC9A TARGETING ANTIBODIES AS A NEW IMMUNOTHERAPY FOR PROSTATE CANCER

A NOVEL MEDIATOR OF CHOLANGIOCARCINOMA THAT HAS POTENTIAL AS A DIAGNOSTIC AND TREATMENT TARGET

TARGETING CEP55 IN TRIPLE-NEGATIVE BREAST CANCER

PREDICTING EARLY-STAGE MELANOMA AT HIGH RISK OF RECURRENCE THROUGH MULTIOMICS PROFILING

FORMULATION DRUG PRODUCT QUALITY ATTRIBUTES IN DERMAL PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELS FOR TOPICAL DERMATOLOGICAL DRUG PRODUCTS AND TRANSDERMAL DELIVERY SYSTEMS

ATTENUATED WEST NILE VIRUS VACCINE

SNAKE VENOM-BASED RAPID WOUND SEALANT

PROOF-OF-CONCEPT STUDIES FOR A NOVEL IMMUNOTHERAPY FOR TRIPLE-NEGATIVE BREAST CANCER AND COMPANION DIAGNOSTIC

BASIC RESEARCH FOR AOARD PROPOSAL 20IOA056 "ADVANCED GROUND TESTING AND SIMULATION OF THE BOUNDARY LAYER TRANSITION (BOLT) FLIGHT EXPERIMENT", DATED 1

BASIC RESEARCH FOR AOARD PROPOSAL 20IOA018 "HEATED WALL SUPERSONIC COMBUSTION TESTING OF HYDROCARBONS IN AXISYMMETRIC MODELS IN THE T4/X3R SHOCK TUNNE

ACHIEVING HIGH SENSITIVITY IN CAVITY OPTOMECHANICAL MAGNETOMETRY

TAS::57 3600::TAS "SENSOR SCHEDULING AND FUSION FOR CATALOG MAINTENANCE OF RESIDENT SPACE OBJECTS"

TAS::57 3600::TAS 'QUANTUM MICROSCOPY: REACHING AND SURPASSING THE QUANTUM LIMITS TO BIOLOGICAL IMAGING'

NICOP - OPTIMIZING COGNITIVE PERFORMANCE BY MIMICKING SLOW-WAVE SLEEP IN THE AWAKE BRAIN.

TAS::57 3600::TAS CLUSTER-STATE QUANTUM ERROR-CORRECTION BASED ON ADS/CFT

CHARACTERIZATION AND VALIDATION OF A NEW MOUSE MODEL OF SPONTANEOUS ENDOMETRIOSIS TO IMPLEMENT TRANSLATION OF BASIC RESEARCH TO THE CLINIC

EPITHELIAL TISSUE MECHANICS: A NEW KEY TO RELAPSE IN CHRONIC INFLAMMATORY BOWEL DISEASE

PRECISION DIAGNOSTICS FOR EARLY MELANOMA DETECTION USING SPATIAL BIOLOGY AND AI-GUIDED IMAGE ANALYSIS

SINGLE MOLECULE BIOMOLECULAR CONDENSATE ANALYSIS IN NEURONS - PROJECT SUMMARY/ABSTRACT BIOMOLECULAR CONDENSATES (BMCS) DEFINE SMALL MEMBRANELESS CELLULAR COMPARTMENTS THAT SEGREGATE SPECIFIC PROTEINS AND NUCLEIC ACIDS TO GENERATE CELLULAR FUNCTIONS. FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING (FRAP) IS CURRENTLY THE METHOD OF CHOICE TO CHARACTERIZE BMCS IN VITRO AND IN VIVO AND DERIVE THE AVERAGE DIFFUSION AND TRAPPING OF MOLECULES TRAPPED IN THESE CONDENSATES. ALTHOUGH FRAP IS A GOOD WAY TO RETRIEVE THESE IMPORTANT METRICS, IT GREATLY LIMITS OUR UNDERSTANDING OF BMCS NANOSCALE ORGANIZATION AND DYNAMICS IN LIVE CELLS AND PRECLUDES THE ANALYSIS OF NANOSCALE BMCS (BELOW THE DIFFRACTION OF LIGHT ~200 NM). SINGLE-MOLECULE IMAGING SUPER-RESOLUTION MICROSCOPY ALLOWS DIRECT IMAGING OF MOLECULES TRAPPED IN BMCS WITH MUCH GREATER SPATIOTEMPORAL RESOLUTION BOTH IN VITRO AND IN LIVE NEURONS, AND HAS THE POTENTIAL TO REVEAL NANOSCALE BMCS AND THEIR EVOLUTION IN THE CONTEXT OF AGEING AND ALZHEIMER’S DISEASE (AD). HOWEVER, THERE ARE CURRENTLY NO BIOINFORMATIC TOOLS TO SPECIFICALLY ANALYZE BMCS AT THE SINGLE-MOLECULE LEVEL. WE HAVE DEVELOPED A NOVEL TOOL, NAMED NANOSCALE SPATIOTEMPORAL INDEXING CLUSTERING (NASTIC), (WALLIS ET AL., BIORXIV, 2021, REF. 7), WHICH OFFERS UNPRECEDENTED INSIGHTS INTO THE DYNAMICS OF PROTEINS UNDERGOING LIQUID-LIQUID PHASE SEPARATION/TRANSITION IN LARGE AND NANOSCALE BMCS, IN LIVE NEURONS. WE IDENTIFIED TAU AND SYNUCLEIN AS CANDIDATES FOR THEIR ABILITY TO GENERATE SYNAPTIC BMCS IN HIPPOCAMPAL NEURONS. NASTIC ANALYSIS REVEALS THAT TAU MOLECULES CAN INDEED FORM SMALL NANOCLUSTERS IN LIVE HIPPOCAMPAL NEURONS IN WHICH THEY EXHIBIT VERY LOW MOBILITY AND SENSITIVITY TO 1,6-HEXANEDIOL, AN ALIPHATIC ALCOHOL USED TO INHIBIT WEAK MOLECULAR INTERACTIONS THAT MEDIATE BMCS. NASTIC WILL BE AT THE CORE OF OUR ABILITY TO MAKE A SIGNIFICANT CONTRIBUTION TO THE UNDERSTANDING OF BMCS IN NEURONS BECAUSE IT OFFERS UNPRECEDENTED OPPORTUNITIES TO EXAMINE THE SPATIOTEMPORAL BEHAVIOUR OF MOLECULES IN THESE CONDENSATES. NASTIC WILL BE DEVELOPED FURTHER TO ENCOMPASS TWO-COLOR SINGLE-MOLECULE ANALYSIS. THIS WILL BE INSTRUMENTAL TO ASSESS THE SPATIOTEMPORAL RELATIONSHIP OF THESE NANOSCALE BMCS WITH THEIR CELLULAR ENVIRONMENT IN 2 AND 3D. WE WILL VALIDATE OUR TWO-COLOR NASTIC IMPLEMENTATION WITH THE PAIRWISE DUAL IMAGING OF TAU WILDTYPE AND AD MUTANT P301L, AND A-SYNUCLEIN. THIS WILL ALLOW US TO DECIPHER THE CO-CLUSTERING DYNAMICS AND EXAMINE POTENTIAL HIERARCHICAL DEPENDENCY OF ONE NANOBMC UPON THE OTHER ALLOWING REFINED UNDERSTANDING OF THE GENERATION OF NANOSCALE BMCS IN SYNAPSES. WE ANTICIPATE THAT THE P301L MUTATION WILL LARGELY INCREASE THE SIZE AND LIFETIME OF THE TAU NANOBMCS AND ALTER THEIR RELATIONSHIP WITH OTHER SYNAPTIC MOLECULES. THE OUTCOME OF THIS GRANT WILL BE THE DEVELOPMENT AND VALIDATION OF AN ANALYTICAL PIPELINE THAT WILL ENABLE EXPLORATION OF THE SPATIOTEMPORAL RELATIONSHIP OF TAU AND A-SYNUCLEIN NANOBMCS IN LIVE HIPPOCAMPAL NEURONS. OUR PROJECT WILL THEREFORE GENERATE DATA AND A MUCH-NEEDED TECHNOLOGY OPENING NEW AVENUES FOR OUR UNDERSTANDING OF BMCS IN NEURONAL FUNCTION AND AD.

EXPLORING THE EFFECT OF HUMAN BLOOD MICRORNAS ON MOSQUITO BIOLOGY

DISCOVERY OF POLYMYXIN-BASED ANTIBACTERIAL AGENTS ACTIVE AGAINST MULTI-DRUG RESIS

TAS::57 3600::TAS BASIC RESEARCH FOR AOARD PROPOSAL 16IOA026 "BIO-INSPIRED PERIPERSONAL SPACE SENSORS FOR SOCIAL INTERACTION"

USING A NOVEL HUMANIZED MOUSE MODEL TO INVESTIGATE HOW EBV INFECTION AT DIFFERENT AGES POTENTIATES DEVELOPMENT OF CNS DEMYELINATING DISEASE

DESIGNER ARTIFICIAL CELLS: CUSTOMIZED CELL MEMBRANE-COATED POROUS NANOPARTICLES FOR TARGETING LETHAL CYTOKINE STORM

INVESTIGATION OF ABLATION PRODUCTS IN THE NEAR WAKE OF A HIGH-SPEED HYPERSONIC VEHICLE

IMAGAING THE LIVING ACTIVITY OF CELLS

BASIC RESEARCH FOR AOARD PROPOSAL 22IOA049 "PROTECTING SUPERCONDUCTING QUBITS FROM QUASIPARTICLE GENERATED BY COSMIC RAYS", DATED 24 MAR 2022 (THE GRA

MOLECULAR TARGETS IN ENDOVASCULAR PROGENITORS TO INHIBIT LUNG AND SKIN FIBROSIS IN SCLERODERMA

EXPERIMENTAL VALIDATION OF THE MMT THERMOCHEMICAL NONEQUILIBRIUM AIR CHEMISTRY MODEL IN THE X2 FREE-PISTON DRIVEN EXPANSION TUBE

IDENTIFYING ANTIGEN-SPECIFIC T AND B CELLS IN SERONEGATIVE RHEUMATOID ARTHRITIS SYNOVIAL TISSUE: IMPLICATIONS FOR ANTIGEN-SPECIFIC IMMUNOTHERAPY

TAS::57 3600::TAS AOARD PROPOSAL 16IOA057 "RAPIDLY EXPANDING NON EQUILIBRIUM HYPERSONIC FLOW", DATED 15 MAR 2016 (THE GRANTEE'S TECHNICAL PROPOSAL) I

TAS::57 3600::TAS AOARD 15IOA093 "MACH 6-8 SCRAMJET COMBUSTION EXPERIMENTS USING HYDROCARBON FUEL" DATED 17 DEC 2014 (THE

TAS::57 3600::TAS 'EXAMINING GROWTH OF TURBULENCE OVER HEATED WALLS IN HYPERSONIC FLOWS'.

TAS::57 3600::TAS COMPUTATIONAL COMPLEXITY OF BOSONS IN LINEAR NETWORKS,

COMPARATIVE EFFECTIVENESS OF EXERCISE, COGNITIVE BEHAVIORAL THERAPY, AND THEIR COMBINATION FOR PEOPLE WITH CHRONIC MUSCULOSKELETAL PAIN AND POOR SLEEP

INVESTIGATING THE INNER-MAGNETOSPHERE HOT ZONE AND THE MAGNETOSPHERE-IONOSPHERE (M-I) CONJUGATE SUBAURORAL FLOWS

BASIC RESEARCH FOR AOARD 114030 "NATURAL MODELS FOR AUTONOMOUS CONTROL OF SPATIAL NAVIGATION, SENSING, AND GUIDANCE, DATED 24 FEB 11" (THE GRANTEE'S

INVENTION OF A GENETIC TOOLKIT FOR IMMUNOMODULATORY GUT BACTERIA TO EXPEDITE THE DEVELOPMENT OF NEW CROHN'S DISEASE THERAPEUTICS

GROUND-TESTS FOR DEVELOPMENT OF SINGLE-STAGE ACCESS-TO-SPACE PROPULSION SYSTEMS

BASIC RESEARCH FOR AOARD PROPOSAL 20IOA087 "CLEAN AND TUNABLE PHASE SLIP QUBIT", DATED 22 SEP 2020 (THE GRANTEE'S TECHNICAL PROPOSAL) IS HEREBY INCORP

BASIC RESEARCH FOR AOARD PROPOSAL 20IOA006 "INTRODUCING THE SUPERCONDUCTING SADDLE POINT QUBIT", DATED 4 NOV 19 (THE GRANTEE'S TECHNICAL PROPOSAL) I

BASIC RESEARCH FOR AOARD 124052 "REBUILDING GOVERNMENT LEGITIMACY IN POST-CONFLICT SOCIETIES: CASE STUDIES OF NEPAL AND AFGHANISTAN, DATED 25 MAY 11"

THERMOMETRY AT THE DOUBLE SHOT-NOISE LIMIT

TAS::57 3600::TAS BASIC RESEARCH FOR AOARD "HUMAN-ROBOT INTERACTIONS: SOCIAL MICRO-ABILITIES TO ESTABLISH AND MANAGE SOCIAL EXCHANGE""

BASIC RESEARCH FOR AOARD 134060 "COMPARISON BETWEEN HYDROGEN AND METHANE FUELS IN A 3-D SCRAMJET AT MACH 8, DATED 16 NOV 12" (THE GRANTEE'S TECHNICAL

TAS::57 3600::TAS 'STUDY OF NON-EQUILIBRIUM WAKES MODEL'

TAS::57 3600::TAS 'ENABLING QUANTUM INFORMATION TECHNOLOGY WITH 60 PHOTONS AND BEYOND'

NICOP - BIO-INSPIRATION FROM A 400 MILLION-YEAR-OLD ARMS-RACE: STOMATOPODS V CEPHALOPODS AND THE FIGHT FOR VISUAL SYSTEM DOMINANCE

TAS::57 3600::TAS AOARD PROPOSAL 17IOA007 "DISCOVERING PATTERNS IN HUMAN-ROBOT INTERACTION: NEW TOOLS FOR COMPLEX ADAPTIVE SOCIAL SYSTEMS", DATED 15

TAS::57 3600::TAS BASIC RESEARCH FOR AOARD PROPOSAL 17IOA005 'DESIGN OF POLYMERS FOR 3D PRINTING VIA NON-EQUILIBRIUM MOLECULAR DYNAMICS SIMULATION'

TAS::573600::XXX "BASIC RESEARCH FOR AOARD 144017 "COMPOSITE REINFORCEMENT USING BORON NITRIDE NANOTUBES - 2, DATED 25 FEB 14" (THE GRANTEE'S TECHNIC

BASIC RESEARCH FOR AOARD 104124 "EXPERIMENTAL STUDY OF HYPERSONIC WING/FIN ROOT HEATING AT MACH 8, DATED 10 JUN 10" (THE GRANTEE'S TECHNICAL PROPOSAL

PURPOSE: IMPROVE THE SELECTION OF FINGERPRINT EXAMINERS FOR LAW ENFORCEMENT AGENCIES BY ADAPTING AND EVALUATING A COGNITIVE ASSESSMENT DEPLOYED IN OTHER COUNTRIES.ACTIVITIES TO BE PERFORMED: THE GOALS OF THE PROJECT WILL BE ACHIEVED BY WORKING WITH SUBJECT MATTER EXPERTS TO DEFINE AND IMPLEMENT A STRATEGY FOR SOURCING OR DEVELOPING APPROPRIATE, SECURE, AND OPERATIONALLY RELEVANT FINGERPRINT STIMULI. AFTER MATERIAL DEVELOPMENT THE TEAM WILL WORK ON ADAPTION AND DELIVERY FORMAT OF THE XQ FRAMEWORK, DATA COLLECTION AND ANALYSIS, AND REPORTING ON METHODOLOGY, ADAPTATION PROCESS, DATA ANALYSIS, AND KEY FINDINGS.EXPECTED OUTCOMES: ADAPTION OF THE XQ FRAMEWORK FOR THE US FEDERAL LAW ENFORCEMENT FINGERPRINT EXAMINER WITH DOCUMENTATION WITH SPECIFICATIONS FOR CURATING STIMULUS SETS, TASK INSTRUCTIONS, VALIDATED DELIVERY FORMAT, AND SCORING GUIDELINES.INTENDED BENEFICIARIES: THE FEDERAL BUREAU OF INVESTIGATION LABORATORY DIVISION WOULD BE THE PRIMARY END-USER OF THE ADAPTED TOOL. A DIRECT AND MAJOR IMPACT WILL BE PROVIDING THE FBI WITH AN EVIDENCE BASE THAT CAN HELP THEM IMPROVE EXAMINER SELECTION. IT WILL ALSO BENEFIT FBI PARTNERS IN OTHER FEDERAL, STATE, AND LOCAL LAW ENFORCEMENT FORENSIC SCIENCE LABORATORIES.SUBRECIPIENT ACTIVITIES: THE UNIVERSITY OF ADELAIDE: SIMULUS SELECTION CRITERIA, DEVELOPMENT OF DELIVERY FORMAT, VALIDATION OF DELIVERY FORMATMURDOCH UNIVERSITY: STATISTICAL METHODOLOGY FOR VALIDATION, PERFORMANCE ANALYSIS, DATA INTERPRETATION, PREPARATION OF TECHNICAL REPORTS, ADMINISTRATIVE ASPECTS.

A POPULATION-BASES ATLAS OF THE ZEBRAFISH BRAIN FOR QUANTITATIVE PHENOTYPIC COMPA

QUANTUM ACCELERATOR EFFICIENT FAST PHOTONIC INTEGRATED CIRCUITS FOR PHOTONIC QUANTUM COMPUTING

TAS::57 3600::TAS AOARD PROPOSAL 17IOA077 'BIO-INSPIRED GPS-FREE NAVIGATION USING MANTIS SHRIMP (STOMATOPOD) VISION', DATED 06 APR 2017 (THE GRANTEE'

BASIC RESEARCH FOR AOARD PROPOSAL 21IOA103 "INVESTIGATING INSTABILITY MECHANISMS AND THEIR IMPACTS ON THE COUPLED SOLAR WIND-MAGNETOSPHERE-IONOSPHERE

BASIC RESEARCH FOR AOARD PROPOSAL 19IOA081 "ELECTROMAGNETIC ENERGY DEPOSITION DURING MAGNETOSPHERE-IONOSPHERE-THERMOSPHERE (M-I-T) COUPLING", DATED 24

TAS::57 3600::TAS AOARD PROPOSAL 17IOA109 'INVESTIGATING IONOSPHERIC HEAT SOURCES AND RESULTANT THERMOSPHERIC RESPONSES', DATED 27 JUN 17 (THE GRANTE

TAS::57 3600::TAS BASIC RESEARCH FOR 15IOA038 "UNLOCKING THE STRUCTURE AND DYNAMICS OF THIN POLYMERIC FILMS" DATED 25 FEB 15.

TAS::573600::XXX "BASIC RESEARCH FOR AOARD 144028 "A UNIQUE MODEL PLATFORM FOR C4 PLANT SYSTEMS AND SYNTHETIC BIOLOGY, DATED 1 MAR 13" (THE GRANTEE'S

BASIC RESEARCH FOR AOARD 134071 "COMPOSITE REINFORCEMENT USING BORON NITRIDE NANOTUBES, DATED 11 JAN 13" (THE GRANTEE'S TECHNICAL PROPOSAL) AND "THE

TAS::57 3600::TAS QUANTUM DOT SUPERLATTICE ENABLED RATIONAL DESIGN IN OPTOELECTRONICS AND HYDROGEN GENERATION

BASIC RESEARCH FOR AOARD 104109 "REBUILDING INSTITUTIONAL LEGITIMACY IN POST-CONFLICT SOCIETIES: AN ASIA-PACIFIC CASE STUDY, INTERPHASE 1-2, DATED 13

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