Weizmann Institute Of Science

GENOME-WIDE ANALYSIS OF REGULATED CHROMOSOMAL DOMAINS: FROM MECHANISMS TO CANCER

PROCUREMENT OF SCIENTIFIC EQUIPMENT OTHER ESSENTIAL RESOURCES SUCH AS LIBRARY JOURNALS, BOTH ELECTRONIC AND PAPER, FOR THREE PROGRAMS THAT PARTICULAR

RADIATION HARDENED PROPERTIES OF SOI FINFETS AND POSTCMOS DEVICES

FAST AND EFFECTIVE ENZYMATIC DECONTAMINATION AND BIODEGRATION OF NERVE AGENTS

COMMODITIES PROJECT OF $1,800,000

NEXT GENERATION STRATEGIES TO INTERCEPT ERBB SIGNALING

COMMODITIES PROJECT OF $1,275,000.00

$1,202,500.00 COMMODITIES AWARD

ROLE OF THREE NOVEL CAMS IN MYELINATING GLIA

ENGINEERING OF PARAXONASES FOR PRE AND POST-TREATMENT OF INTOXICATION BY A BROAD SPECTRUM OF NERVE AGENTS AND PESTICIDES-PROJECT3

FUNCTIONAL ANALYSIS OF THE P53 TUMOR SUPPRESSOR

MOLECULAR EVOLUTION OF HUMAN PON TO DESIGN ENHANCED CATALYTIC EFFICIENCY FOR HYDROLYSIS OF NERVE AGENTS

FY 12 NEW GRANT - FEINBERG

FY 2011 - NEW GRANT - FEINBERG GRADUATE SCHOOL

FY 10 NEW GRANT - FEINBERG GRADUATE SCHOOL

2018 ASHA GRANT COMMODITIES

GLOBALS - GLOBAL OMIC BIOMARKER RESEARCH FOR ALS

TAS 57 3600::TAS "HUMAN SOCIAL CHEMOSIGNALING: FROM HUMAN-HUMAN TO HUMAN-MACHINE INTERACTIONS"

ASHA FUNDED PROGRAM

UNCOVERING THE COEVOLUTION OF THE MICROENVIRONMENT IN BREAST CANCER METASTASIS: TOWARD DISCOVERY OF NOVEL THERAPEUTIC TARGETS

MRI STUDIES OF ANGIOGENESIS IN OVARIAN CANCER

SECURE INTERACTIONS WITH QUANTUM DEVICES

INVESTIGATIONS OF IMPLODING MAGNETIZED AND NON-MAGNETIZED PLASMAS USING HIGH RESOLUTION NOVEL SPECTROSCOPY INCLUDING THE DEVELOPMENT OF X-RAY SPECTROSCOPY FOR HED RESEARCH

BASIC AND APPLIED RESEARCH IN HIGH TEMPERATURE PLASMAS. PR# 67-0202-13.

SINGLE-MOLECULE FLUORESCENCE STUDIES OF PROTEIN FOLDING

A STRUCTURAL BIOLOGY AND PROTEIN ENGINEERING APPROACH TO THE DEVELOPMENT OF ANTIDOTES AGAINST THE INHIBITION OF HUMAN ACETYLCHOLINESTERASE BY OP-BASE

MULTI-DIMENSIONAL NMR OF HIV-1 ENVELOPE GLYCOPROTEINS

COMMODITIES AWARD IN THE AMOUNT OF $750,000

ASHA FY 2014 AWARD FOR COMMODITIES

CRYSTALLOGRAPHIC STUDIES ON RIBOSOMAL PARTICLES

ANALYSIS OF THE PREDICTABILITY OF LUNG CANCER USING DNA REPAIR FUNCTIONAL ASSAYS AND CRYOPRESERVED BLOOD SAMPLES OF THE PLCO PROSPECTIVE COHORT - PROJECT SUMMARY/ABSTRACT ELUCIDATING THE ETIOLOGY OF LUNG CANCER IS INTERWOVEN WITH THE IDENTIFICATION OF RISK FACTORS FOR THE DISEASE, AND IS CRITICAL TO ADVANCE PREVENTION, AND ASSIST EARLY DETECTION OF THIS LETHAL TUMOR. WHILE SMOKING STATUS AND AGING ARE WELL DOCUMENTED KEY LUNG CANCER RISK FACTORS, ALONG WITH SEVERAL ADDITIONAL RISK FACTORS INCLUDING CERTAIN ENVIRONMENTAL AND OCCUPATIONAL CARCINOGENIC EXPOSURES, THERE IS A GAP IN OUR KNOWLEDGE OF OTHER IMPORTANT CAUSES OF THE DISEASE INCLUDING BIOLOGICAL PROCESSES THAT MAY MODIFY THE IMPACT OF EXPOSURES OR BE INDEPENDENT RISK FACTORS. BECAUSE DNA REPAIR ABILITY IS KEY IN AVOIDING MUTATIONS AND PREVENTING CANCER, AND LIKELY REFLECTS MULTIPLE INHERITED AND OTHER INFLUENCES, WE HAVE PREVIOUSLY DEVELOPED A PANEL OF THREE FUNCTIONAL DNA REPAIR BLOOD TESTS, WHICH DIRECTLY MEASURE AN INDIVIDUAL’S EFFECTIVENESS AT REPAIRING OXIDATIVE DNA DAMAGE BY THE ENZYMES OGG1, MPG AND APE1. USING THESE TESTS IN A CASE- CONTROL STUDY, WE FOUND THAT A LOW DNA REPAIR SCORE, CALCULATED FROM THE THREE TESTS, WAS STRONGLY ASSOCIATED WITH LUNG CANCER IN ADDITION TO AND INDEPENDENT OF SMOKING. THIS WAS RECENTLY REPLICATED IN A SECOND CASE-CONTROL STUDY, SUGGESTING THAT ADDING THE DNA REPAIR SCORE TO CURRENT LUNG CANCER RISK MODELS IS LIKELY TO SUBSTANTIALLY IMPROVE RISK PREDICTION. THE DATA SO FAR IS CONSISTENT WITH A CAUSATIVE ROLE IN LUNG CANCER, BUT BECAUSE THE FINDINGS ARE BASED ON CASE-CONTROL STUDIES, WHERE DISEASE BIAS CANNOT BE RULED OUT, PERSUASIVE EVIDENCE TO SUPPORT A ROLE OF A LOW DNA REPAIR SCORE IN LUNG CANCER ETIOLOGY REQUIRES DEMONSTRATING ITS ABILITY TO PREDICT LUNG CANCER IN PROSPECTIVE COHORT STUDIES. OUR GOAL IS TO EXAMINE THE PREDICTIVE ABILITY OF THE DNA REPAIR SCORE FOR LUNG CANCER IN A NESTED CASE- CONTROL STUDY WITHIN A PROSPECTIVE COHORT, NAMELY THE PLCO SCREENING TRIAL. DNA REPAIR ACTIVITY WILL BE MEASURED IN EXPANDED T CELLS FROM PLCO PRE-DIAGNOSTIC CRYOPRESERVED VIABLE WHOLE BLOOD SAMPLES OF CURRENT SMOKERS AND NEVER-SMOKERS WHO SUBSEQUENTLY DEVELOPED LUNG CANCER, AND WILL BE COMPARED TO SAMPLES FROM MATCHED CONTROLS WHO DID NOT DEVELOP ANY TYPE OF CANCER, FROM WHICH THE ABILITY TO PREDICT LUNG CANCER CAN BE INFERRED. FURTHER, DNA REPAIR TESTS WILL BE EXPANDED WITH THREE NEW FUNCTIONAL TESTS FOR THE DNA REPAIR ENZYMES TDG, SMUG1 AND NEIL1. USING A SET OF TEST SAMPLES RECEIVED FROM THE PLCO TRIAL, WE HAVE DEMONSTRATED THAT T CELLS COULD BE EFFECTIVELY AND EFFICIENTLY EXPANDED FROM WHOLE BLOOD SAMPLES CRYOPRESERVED FOR 12 OR 20 YEARS, AND WERE SUITABLE FOR MEASURING ALL SIX DNA REPAIR ENZYME ACTIVITIES, YIELDING REPRODUCIBLE VALUES COMPARABLE TO FRESH LYMPHOCYTES. A SUCCESSFUL OUTCOME OF THIS STUDY WILL SUPPORT THE ROLE OF SUB-OPTIMAL DNA REPAIR OF OXIDATIVE DNA DAMAGE IN THE ETIOLOGY OF LUNG CANCER, AND WILL FACILITATE THE ADAPTATION OF THE DNA REPAIR SCORE INTO CLINICALLY-VALIDATED BIOMARKERS FOR RISK ASSESSMENT OF LUNG CANCER. THIS IS EXPECTED TO IMPROVE RISK ESTIMATES, AND PROVIDE BETTER SELECTION CRITERIA FOR EARLY DETECTION OF LUNG CANCER BY METHODS SUCH AS LOW-DOSE CT. 1

BUILDING A MODEL OF AN AUTONOMOUS SELF-REPLICATING CELL ON A CHIP

NEW START GRANT

AUTONOMOUS CELL-FREE RIBOSOME BIOGENESIS RECONSTITUTED ON A PHOTONIC CHIP

GENETICALLY PROGRAMMED MULTICOMPONENT ASSEMBLY IN DNA COMPARTMENTS ON A CHIP

GAS PUFF Z PINCH EXPERIMENTS AT 1 MA

DNA REPAIR BIOMARKERS FOR CANCER RISK ASSESSMENT AND EA*

DENSE ATOMIC ARRAYS IN OPTICAL TWEEZERS FOR EFFICIENT QUANTUM NODES

THE INFLUENCE OF SYNTHETIC AND BIOGENIC MACROMOLECULES ON CRYSTALLIZATION WITHIN POLYMER-RICH PHASES

NEW START GRANT

NICOP - STUDY OF THE IMPLOSION OF A MAGNETIZED GAS-PUFF COLUMN WITH PRE-EMBEDDED AXIAL FIELDS

PLASMA THERMALIZATION AND TURBULENCE AT THE STGNATING PLASMA IN A 1 MA Z PINCH EXPERIMENT

TAS::57 3600::TAS "INVESTIGATION OF THE PROPERTIES OF IMPLODING PLASMA AND THE MAGNETIC-FIELD DISTRIBUTION USING A NOVEL SPECTROSCOPIC TECHNIQUE"

EXPLORING DECOHERENCE WITH LONG-LIVED SUPERCONDUCTING CAVITY QUBITS.

DEVELOPING NOVEL AUTOMATED APPARATUS FOR STUDYING BATTERY OF SOCIAL BEHAVIORS IN MUTANT MOUSE MODELS FOR AUTISM

GRANT

RELIABLE PREDICTION OF ELECTRONIC AND OPTICAL PROPERTIES OF LAYERED AND 2D MATERIALS FROM TRANSFERABLE SCREENED RANGE-SEPARATED HYBRID FUNCTIONALS

NICOP - TORSION OF CARBON AND INORGANIC NANOTUBES: FROM FUNDAMENTAL STUDIES TO A #NANOTUBE GYRO#

NICOP - ELECTRIC-FIELD CONTROL OF GENE EXPRESSION IN ON-CHIP DNA COMPARTMENTS

LASER RESEARCH IN ISRAEL

TAS::57 3600::TAS "OPTICAL ABSORPTION IN MOLECULAR CRYSTALS FROM TIME-DEPENDENT DFT"

ELUCIDATING THE MECHANISM OF AMYLOID-BETA'S PATHOLOGICAL AGGREGATION

INTEGRATED QUANTUM OPTICS

2020 ASHA GRANT COMMODITIES PROJECT

CSP - STRUCTURAL MASS SPECTROMETRY WORKSHOP

TIMELINES IN BIOLOGY 2014

ISRAEL-GREECE JOINY MEETING ON NANOTECHNOLOGY AND BIONANOSCIENCE