Dalhousie University

VISUAL SYSTEM DEVELOPMENT AND SYNAPTOGENESIS

TAS::57 3600::TAS "TRUSTED QUANTUM SOFTWARE VIA A FORMALLY VERIFIED FUNCTIONAL QUANTUM PROGRAMMING LANGUAGE"

DEPENDENT TYPE THEORY FOR VERIFIED QUANTUM SOFTWARE

TGF-BETA SIGNALING IN POST-TRAUMATIC EPILEPTOGENESIS: NOVEL MECHANISMS AND THERAPEUTIC TARGET

SENSING OF THE OCEAN WITH DEEP ACOUSTIC LANDERS AND PROFILERS

PROPAGATION AND DIRECTIONAL SCATTERING OF OCEAN WAVES IN THE MARGINAL ICE ZONE AND NEIGHBORING SEAS

NICOP - THE EFFECT OF OCEAN SURFACE WAVES ON LONG DURATION, WIDE BANDWIDTH WAVEFORMS IN HIGH DUTY CYCLE SONARS

INVESTIGATING TREPONEMA PALLIDUM PATHOBIOLOGY IN THE CERVICOVAGINAL NICHE - ABSTRACT: GLOBALLY, INFECTIOUS AND CONGENITAL SYPHILIS CASES CONTINUE TO INCREASE AT ALARMING RATES. IN THE UNITED STATES, SYPHILIS INFECTION RATES REMAIN HIGHEST AMONG MEN, BUT CASES IN WOMEN ARE DISPROPORTIONATELY ACCELERATING, SHOWING AN 866% INCREASE OVER THE PAST DECADE CONCURRENT WITH A 10-FOLD INCREASE IN CONGENITAL INFECTIONS. THE HIGHLY INVASIVE SYPHILIS BACTERIUM, TREPONEMA PALLIDUM, IS ACQUIRED DURING CONTACT BETWEEN AN INFECTIOUS LESION AND MUCOSAL SITES, SUCH AS THE LOWER FEMALE GENITAL TRACT (VAGINA AND CERVIX). FROM THE INITIAL INFECTION SITE, TREPONEMES ENTER THE BLOODSTREAM AND UNDERGO SYSTEMIC DISSEMINATION. HOWEVER, THE MOLECULAR EVENTS PRECEDING VASCULAR DISSEMINATION THAT SUPPORT T. PALLIDUM PENETRATION OF CERVICOVAGINAL EPITHELIUM HAVE YET TO BE INVESTIGATED. THIS RESEARCH PROPOSAL AIMS TO ADDRESS THIS IMPORTANT GAP IN KNOWLEDGE BY INVESTIGATING (1) HOW T. PALLIDUM INTERACTS WITH VAGINAL AND ENDOCERVICAL EPITHELIAL BARRIERS TO MEDIATE ADHESION AND BARRIER TRAVERSAL AND (2) WHETHER VAGINAL MICROBIOTA CAN INHIBIT OR AUGMENT T. PALLIDUM INTERACTIONS WITH CERVICOVAGINAL EPITHELIAL BARRIERS. THIS WORK WILL USE IN VITRO CO-CULTURE MODELS TO ADVANCE OUR UNDERSTANDING OF HOW T. PALLIDUM ESTABLISHES INFECTIONS IN THE CERVICOVAGINAL NICHE AND WHETHER THE VAGINAL MICROBIOME REPRESENTS A MODIFIABLE RISK FACTOR FOR MODULATING SUSCEPTIBILITY TO T. PALLIDUM INFECTION. THIS WORK IS EXPECTED TO IDENTIFY NEW AVENUES FOR BIOMEDICAL INTERVENTION AMENABLE FOR USE IN FEMALES, SUCH AS PROBIOTICS OR POSTBIOTICS THAT COULD REDUCE THE RISK OF ACQUIRING SYPHILIS, WITH THE ULTIMATE GOAL OF DIMINISHING THE BURDEN OF INFECTIOUS AND CONGENITAL SYPHILIS CASES.

SR: PERSISTENT SIMULTANEOUS LOCALIZATION AND MAPPING (SLAM) WITH CHANGE DETECTION IN DYNAMIC UNDERWATER ENVIRONMENTS

PRIORITIZING CLINICAL CANDIDATES FOR MOTOR RECOVERY IN MULTIPLE SCLEROSIS: KINEMATIC GAIT ANALYSIS OF MICE SUBJECTED TO EXPERIMENTAL AUTOIMMUNE.

OPTICS, ACOUSTICS AND STRESS IN A NEARSHORE BOTTOM NEPHELOID LAYER

EXPERIMENTAL COMPARISON OF HIGH DUTY CYCLE AND PULSED ACTIVE SONARS IN A LITTORAL ENVIRONMENT

ALLERGIC DISEASE AND ALLERGY MEDICATIONS IN THE REGULATION OF BREAST CANCER

INTRANASAL NANOPARTICLE DRUG DELIVERY TO PROMOTE FUNCTIONAL RECOVERY IN MULTIPLE SCLEROSIS

ANTIFOULING PERFORMANCE: THEORETICAL MODELLING

THIS GRANT IS A CONTINUATION OF N00014-14-1-0226 EXPERIMENTAL COMPARISON OF HIGH DUTY CYCLE AND PULSED ACTIVE SONARS IN A LITTORAL ENVIRONMENT

ALLERGIC DISEASE AND ALLERGY MEDICATIONS IN THE REGULATION OF BREAST CANCER

THE RESPONSE OF MUDDY TIDAL FLATS TO TANGENTIAL AND NORMAL STRESSES AND ITS RELATIONSHIP TO SEDIMENT EROSION RATES

HUMAN CHALLENGE MODEL OF BORDETELLA PERTUSSIS INFECTION

RESOLVING TIME SCALES OF REMOVAL OF SUSPENDED SEDIMENT WITH A GEOSTATIONARY OCEAN COLOR SATELLITE

OPTICAL CONSTITUENTS AT THE MOUTH OF THE COLUMBIA RIVER: VARIABILITY AND SIGNATURE IN REMOTELY SENSED REFLECTANCE

ASSESSMENT OF A NEW METHOD FOR ESTIMATING DENSITY OF SUSPENDED PARTICLES

A SUBMERSIBLE DIGITAL IN-LINE HOLOGRAPHIC MICROSCOPE FOR MONITORING AND TRACKING OF PHYTOPLANKTON AND PARTICULATES IN RIVERS, LAKES AND OCEANS

QUANTIFYING THE EFFECTS OF PROPAGATION ON CLASSIFICATION OF CETACEAN VOCALIZATIONS

PROCESSES AFFECTING EXCHANGE OF MUD BETWEEN TIDAL CHANNELS AND FLATS

PARTICLE AND OPTICAL PROPERTIES AT THE MOUTH OF THE COLUMBIA RIVER: VARIABILITY AND SIGNATURE IN REMOTELY SENSED REFLECTANCE

INTEGRATING ENVIRONMENTAL OPTICS INTO MULTIDISCIPLINARY, PREDICTIVE MODELS OF OCEAN DYNAMICS

REMOTE DETECTION OF SUSPENDED SEDIMENT STRATIFICATION IN TIDAL SEAS

THREE-DIMENSIONAL OCEAN NOISE MODELING

OPTICAL CONSTITUENTS ALONG A RIVER MOUTH AND INLET: VARIABILITY AND SIGNATURE IN REMOTELY SENSED REFLECTANCE

PHASE CHANGE MATERIALS FOR TEMPERATURE CONTROL OF HIGH POWER, SHORT DURATION ELECTRONICS

TOWARDS DEVELOPMENT OF NEW MATERIALS WITH IMPROVED THERMAL STRESS PROPERTIES

OPTICS, ACOUSTICS, AND STRESS IN A NEARSHORE BOTTOM NEPHELOID LAYER

SUPPORT SPACE ENGINEERING, TECHNOLOGY AND ARTIFICIAL INTELLIGENCE PROGRAMMING FOR YOUTH IN NOVA SCOTIA, CANADA.

DEVELOPMENT OF TOOLS FOR REMOTE DETECTION AND PREDICTION OF LOW-STRENGTH MUDS IN ENERGETIC COASTAL ENVIRONMENTS

WORKSHOP ON SUSTAINABLE APPROACHES TO MATERIALS RESEARCH, INCLUDING LIFE CYCLE ASSESSMENT

PROVIDE OFFLINE STEM RESOURCES FOR UNDERSERVED YOUTH ACROSS THE ATLANTIC COAST OF CANADA

TO COVER TRAVEL COSTS FOR UP TO 2 U.S. EXPERTS TO PARTICIPATE IN AN ARCTIC RESEARCH SYMPOSIUM IN HALIFAX.