The Governors Of The University Of Alberta

PLACEBO CONTROLLED, DOUBLE-BLIND STUDY TO EVALUATE THE EFFICACY, SAFETY, AND TOLERABILITY OF SCX-001 CREAM IN BURN PATIENTS WITH STANDARDIZED DEEP DERMAL INCISIONS...NEW COOPERATIVE AGREEMENT, SIGNED ON 9/6/2019, EFFECTIVE 9/30/2019, DISTRIBUTED 9/6/2019, FAADC 9/10/2019

LINKING ISLET CELL FUNCTION AND IDENTITY FROM IN VITRO TO IN SITU

MOTONEURON PROPERTIES IN CHRONIC SPINAL INJURY

IMPACT OF EXERCISE ON SARCOPENIA

EXPLOITING CROSS-REACTIVE, CONSERVED EPITOPES IN PLASMODIUM VIVAX TO DEVELOP A VACCINE AGAINST FALCIPARUM PLACENTAL MALARIA.

LONGITUDINAL STUDY OF COGNITIVE AGING

OPTIMIZING TRANSHUMERAL OSSEOINTEGRATION PROSTHESIS CONTROL

PRECLINICAL TESTING OF INTRASPINAL MICROSTIMULATION FOR RESTORING WALKING AFTER SEVERE SCI. NEW AWARD.

ROLE OF CD22 IN THE GERMINAL CENTER REACTION

AN INNOVATIVE APPROACH FOR NONINVASIVE EVALUATION OF STABILITY AT THE IMPLANT-BONE INTERFACE FOR TRANSFEMORAL OSSEOINTEGRATED IMPLANTS

MECHANISMS OF ISLET FAILURE IN CF - PROJECT SUMMARY DIABETES IS A MAJOR CO-MORBIDITY OF CYSTIC FIBROSIS (CF), AFFECTING 20% OF ADOLESCENTS AND 40-50% OF ADULTS WITH CF. CF-RELATED DIABETES (CFRD) IS ASSOCIATED WITH WORSE DISEASE OUTCOMES AND A 4-FOLD INCREASE IN MORTALITY RELATIVE TO CF PATIENTS WITHOUT DIABETES. IMPAIRED INSULIN RELEASE IS THE KEY DEFECT UNDERLYING CFRD, BUT ITS ETIOLOGY IS POORLY UNDERSTOOD. PANCREATIC DUCTAL EPITHELIAL CELLS (PDECS) ARE THE MAJOR SOURCE OF PANCREATIC CFTR AND ARE THE INITIATING SITE OF CF PANCREAS PATHOLOGY, WHICH LEADS TO DESTRUCTION OF PANCREATIC ACINI (IN 85% OF CF CASES). ISLETS ARE RELATIVELY PRESERVED IN THE CF PANCREAS. HOWEVER, ISLET MORPHOLOGY IS PROFOUNDLY ALTERED, INCLUDING INCREASED Α CELLS (ALTHOUGH GLUCAGON RELEASE IS IMPAIRED IN CF), AND LOSS OF ISLET CAPILLARIES AND MACROPHAGES. THESE CELL TYPES SUPPORT NORMAL Β CELL FUNCTION AND SO THEIR DISRUPTION IN CF LIKELY CONTRIBUTES TO INSULIN DEFICIENCY. RECENT STUDIES, INCLUDING OUR PRELIMINARY DATA, SHOW THAT KNOCKDOWN/INHIBITION OF CFTR IN PDECS CAN INDUCE ISLET DYSFUNCTION (IMPAIRED INSULIN RELEASE). HOWEVER, THE RELATIVE CONTRIBUTION OF DIRECT PDEC-ISLET EFFECTS VS. THOSE OCCURRING INDIRECTLY VIA PANCREATIC ACINAR CELLS OR OTHER ISLET CELLS ARE UNKNOWN. MOREOVER, THE UNDERLYING MECHANISMS ARE ENTIRELY UNEXPLORED. WE HYPOTHESIZE THAT CFTR-DEFECTIVE HUMAN PDECS EXERT DETRIMENTAL EFFECTS ON Β CELLS, BOTH DIRECTLY AND INDIRECTLY, TO IMPAIR INSULIN RELEASE AND Β CELL HEALTH. WE WILL PERFORM STUDIES IN PRIMARY HUMAN CELLS (PDECS, ISLET Β-CELLS, Α- CELLS, ACINAR CELLS, ISLET ENDOTHELIAL CELLS AND MACROPHAGES). WE WILL ALSO USE CF DONOR PLURIPOTENT STEM CELL (PSC)-DERIVED PDECS. SPECIFIC AIM 1: TO DETERMINE WHETHER CFTR-DEFECTIVE PDECS IMPAIR INSULIN RELEASE VIA DIRECT EFFECTS ON ISLET Β-CELLS. TRANSCRIPTOMIC AND PROTEOMIC ANALYSIS WILL BE DONE ON PDECS AND PDEC-DERIVED EXTRACELLULAR VESICLES USING PRIMARY OR HPSC-DERIVED PDECS ± CFTR MUTATIONS. FROM THESE DATA, WE WILL IDENTIFY KEY PATHWAYS THAT MEDIATE CROSS TALK BETWEEN PDECS AND Β CELLS. THE IMPACT OF THOSE PATHWAYS WILL THEN BE TESTED IN INTERVENTION STUDIES USING ISLETS AND PRIMARY HUMAN Β CELLS. SPECIFIC AIM 2: TO DETERMINE WHETHER CFTR-DEFECTIVE PDECS IMPAIR INSULIN RELEASE INDIRECTLY. WE WILL RECAPITULATE THE KNOWN TOXIC EFFECTS OF CFTR-DEFECTIVE PDECS ON ACINAR CELLS USING AN IN VITRO SYSTEM AND DETERMINE WHETHER ACINAR ELICITED FACTORS CAN THEMSELVES IMPAIR Β CELL FUNCTION. NEXT, WE WILL SYSTEMATICALLY INTERROGATE THE EFFECT OF CFTR-DEFECTIVE PDECS AND/OR ACINAR CELLS PREVIOUSLY EXPOSED TO THOSE PDECS ON THE FUNCTION, IDENTITY AND VIABILITY OF ISLET Α CELLS, ENDOTHELIAL CELLS AND MACROPHAGES. SPECIFIC AIM 3: EFFECT OF PDEC-CFTR KNOCKDOWN ON INSULIN RELEASE IN HUMAN PANCREAS SLICES. PANCREAS SLICES, WHICH PRESERVE THE 3D ARRANGEMENT OF PANCREATIC CELL TYPES, WILL BE USED TO DETERMINE THE EFFECT OF PDEC-CFTR LOSS ON INSULIN RELEASE OVER TIME, ALONG WITH CONCURRENT MEASUREMENT OF THE VIABILITY/FUNCTION OF ACINAR CELLS AND Α-CELLS ALONG WITH MORPHOLOGICAL CHANGES IN ISLET ENDOTHELIAL CELLS AND MACROPHAGES.

LONGITUDINAL STUDY OF COGNITIVE AGING

PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS

INTRASPINAL MICROSTIMULATION FOR RESTORING LIMB MOVEMENT

RECOVERY OF MOTONEURON EXCITABILITY AFTER SPINAL INJURY

EVALUATION OF A NOVEL T CELL-DERIVED PEPTIDE FOR DELIVERY OF ANTISENSE OLIGONUCLEOTIDES TO TREAT DMD CARDIOMYOPATHY

STUDIES ON THE DYNAMIC FAILURE OF DAMAGED AND GRANULAR BRITTLE MATERIALS

ISLET TRANSPLANT - COSTIMULATORY BLOCKADE WITH LEA29Y

ULTRASENSITIVE BISPECIFIC ANTIBODY ASSAY FOR SARS VIRUS

ROLE OF SIGLEC-10/G AS A TUMOR SUPPRESSOR IN B-CELLS

PARKINSON DISEASE NEUROPROTECTION TRIAL: CLINICAL CENTER

HIGH FREQUENCY WEARABLE AND TRANSPARENT ELECTROSTRICTIVE ROW-COLUMN ARRAYS FOR WHOLE BRAIN FUNCTIONAL IMAGING - PROJECT SUMMARY/ABSTRACT SECTION ENTER THE TEXT HERE THAT IS THE NEW ABSTRACT INFORMATION FOR YOUR APPLICATION. THIS SECTION MUST BE NO LONGER THAN 30 LINES OF TEXT. WE PROPOSE THE DEVELOPMENT OF A NOVEL BIAS-SWITCHABLE ROW-COLUMN 2D ULTRASOUND TRANSDUCER ARRAY TECHNOLOGY FOR 3D ULTRASOUND AND PHOTOACOUSTIC IMAGING OF WHOLE-BRAIN FUNCTIONAL ACTIVITY WITH POTENTIAL FOR A WEARABLE FORMAT FOR AWAKE AND MOVING ANIMALS. THESE CAN BE DEVELOPED INTO HIGH- FREQUENCY ARRAYS AND EVEN TRANSPARENT VARIANTS THAT SHOULD ALLOW OPTICAL AND ULTRASONIC IMAGING DOWN TO RESOLUTIONS OF 30 MICRONS, APPROACHING SINGLE-NEURON SCALES. UNLIKE PREVIOUS 2D ARRAY TECHNOLOGIES THAT REQUIRE WIRES CONNECTING TO EACH TRANSDUCER ELEMENT, OUR APPROACH REQUIRES ONLY ROW- AND COLUMN ADDRESSING, YET PERMITS READOUT FROM EVERY ELEMENT OF THE ARRAY USING NOVEL ELECTROSTRICTIVE BIAS SWITCHING APPROACHES. THE TECHNOLOGY PROMISES FIRST-OF-IT’S KIND VOLUMETRIC FUNCTIONAL BRAIN IMAGING OF BLOOD-FLOW CHANGES, BLOOD OXYGENATION CHANGES, AND EVEN NEURON ACTIVITY OVER THE WHOLE BRAINS OF AWAKE AND MOVING RODENTS. THE ARRAY OFFERS SIGNIFICANT POTENTIAL FOR NEXT-GENERATION NEUROSCIENCE EXPERIMENTS INVOLVING BOTH OPTICAL AND ACOUSTIC METHODS, INCLUDING FUTURE WORK COMBINING FUNCTIONAL ULTRASOUND AND PHOTOACOUSTIC IMAGING WITH OPTOGENETICS, OPTICAL MICROSCOPY OF GENETICALLY-ENCODED REPORTERS OF NEURON ACTIVITY, ULTRASOUND NEURO-STIMULATION, ULTRASOUND BLOOD-BRAIN BARRIER DISRUPTION FOR DRUG DELIVERY, AND MORE. THE ARRAYS HAVE CONSIDERABLE TRANSLATIONAL POTENTIAL FOR FUTURE HUMAN SUBJECT IMAGING IN NEUROSURGERIES, NEONATES, AND WITH POTENTIAL FOR IMPLANTABLE DEVICES FOR LONGITUDINAL FUNCTIONAL BRAIN IMAGING. OUR RESEARCH METHODS INCLUDE CAREFUL DESIGN AND FABRICATION OF THESE HIGH-FREQUENCY ARRAYS WITH SPECIAL ATTENTION TO TRANSPARENT VARIANTS. WE ALSO DEVELOP NOVEL IMAGING SCHEMES AND IMPLEMENT THESE SCHEMES ON PROGRAMMABLE ULTRASOUND SYSTEMS. TESTING WILL INCLUDE ARRAY CHARACTERIZATION, IMAGING PHANTOMS, IMAGING CELLS EXPRESSING NEAR-INFRARED (NIR) GENETICALLY-ENCODED REPORTERS OF NEURON CALCIUM ACTIVITY. IF SUCCESSFUL, FUTURE WORK WILL GO ON TO IMPLEMENT ANIMAL IMAGING EXPERIMENTS AIMING TO VISUALIZE FUNCTIONAL BRAIN IMAGING DUE TO WHISKER STIMULATION IN BOTH ANESTHETIZED AND AWAKE- MOVING ANIMALS.

ALBERTA PREGNANCY OUTCOMES AND NUTRITION (APRON) - TOXICANT-DIET INTERACTIONS ON

DYNAMIC FAILURE AND FRAGMENTATION OF ADVANCED CERAMICS 1: COMPRESSION AND IMPACT EXPERIMENTS

WEARABLE ELECTROSTRICTIVE ROW-COLUMN ULTRASOUND ARRAYS FOR LONGITUDINAL ECHOCARDIOGRAPHY - PROJECT SUMMARY / ABSTRACT IN PATIENTS ADMITTED TO INTENSIVE CARE UNITS (ICUS) WITH SHOCK (LOW BLOOD PRESSURE) THAT RESULTS IN BOTH CLINICAL AND BIOCHEMICAL EVIDENCE OF TISSUE HYPOPERFUSION DUE TO INADEQUATE CARDIAC OUTPUT, CLINICIANS COMMONLY SEEK TO ASSESS AND MONITOR CARDIAC FUNCTION, BUT ALL AVAILABLE INVASIVE AND NON-INVASIVE METHODOLOGIES HAVE SIGNIFICANT LIMITATIONS AND/OR RISK. THE GOLD STANDARD METHOD TO ASSESS CARDIAC OUTPUT AND SHOCK STATES IS A PULMONARY ARTERIAL CATHETER (PAC) WHICH IS INSERTED THROUGH A VENOUS CANULA AND PASSES THROUGH THE RIGHT SIDE OF THE HEART INTO THE PULMONARY ARTERY. THE ADVANTAGES OF THIS MODALITY ARE THAT IT PROVIDES INFORMATION ON RIGHT AND LEFT HEART PRESSURES, AND ALLOWS FOR THE CALCULATION OF CARDIAC OUTPUT VIA THERMODILUTION TECHNIQUES. ITS DISADVANTAGES INCLUDE THE INVASIVE NATURE RESULTING THE POTENTIAL RISK OF VASCULAR INJURY. MOREOVER, CARDIAC OUTPUTS ARE INACCURATE IN COMMON CARDIAC ARRHYTHMIAS (EX ATRIAL FIBRILLATION) AND VALVULAR LESIONS (EX TRICUSPID REGURGITATION), AND ONLY PROVIDES INFORMATION ON OVERALL CARDIAC FUNCTION WITHOUT DIRECT INFORMATION ON LEFT AND RIGHT HEART FUNCTION. NON-INVASIVE CARDIAC OUTPUT MONITORS (NICOMS) USE PROPRIETARY BIO-IMPEDANCE OR ARTERIAL LINE AREA UNDER THE CURVE ALGORITHMS TO ESTIMATE CARDIAC OUTPUT. WHILE THESE ARE MINIMALLY INVASIVE, THEY HAVE NOT BEEN WELL VALIDATED IN PATIENTS IN CARDIOGENIC SHOCK AND PROVIDE NO INFORMATION ON LEFT AND RIGHT HEART FUNCTION. FINALLY, POINT OF CARE ULTRASOUND (POCUS) ALLOWS ECHOCARDIOGRAPHIC EVALUATION OF LEFT AND RIGHT HEART FUNCTION, BUT IT IS NOT WELL SUITED FOR EVALUATION OF CONTINUOUS OR TEMPORAL TRENDS IN CARDIAC FUNCTION GIVEN IT REQUIRES A CLINICIAN TO ACQUIRE IMAGES AT THE BEDSIDE. A WEARABLE ULTRASOUND PROBE THAT WOULD ENABLE HANDS-FREE LONGITUDINAL IMAGING OF PATIENTS WOULD PROVE TO BE OF CONSIDERABLE VALUE IN THE ICU ENVIRONMENT. IN THIS PROPOSAL WE INTRODUCE A RADICALLY NEW WEARABLE ULTRASOUND TECHNOLOGY, BIAS-SENSITIVE ELECTROSTRICTIVE TOP- ORTHOGONAL-TO-BOTTOM ELECTRODE (TOBE) ARRAYS. THESE TOBE ARRAYS OFFER READOUT FROM EVERY ELEMENT OF A 2D ARRAY THROUGH BIASING CONTROL AND TRANSMIT-RECEIVE CONTROL OF ONLY ROWS AND COLUMNS, RATHER THAN REQUIRE WIRING FROM EVERY ELEMENT. WITH NOVEL READOUT APPROACHES, THESE ARRAYS WILL BE DEMONSTRATED TO ACHIEVE IMAGE QUALITY COMPARABLE TO A LINEAR ARRAY, BUT WITH FULL ELECTRONIC 3D SCANNING CAPABILITIES. UNLIKE MATRIX PROBES THAT RELY ON COMPLICATED MICRO-BEAMFORMERS, OUR APPROACH IS SIMPLER, YET ALLOWS FOR ADVANCED IMAGING MODES SUCH AS ULTRAFAST IMAGING AT THOUSANDS OF FRAMES PER SECOND. WE PROPOSE THE DEVELOPMENT OF SUCH ULTRAFAST IMAGING MODES WITH WEARABLE TOBE PROBES FOR ANGLE-AGNOSTIC FLOW ESTIMATION AND LONGITUDINAL ELECTRONIC TRACKING OF RIGHT AND LEFT HEART FUNCTION. THE ANGLE-AGNOSTIC FLOW ESTIMATION AVOIDS ERRORS DUE TO UNKNOWN DOPPLER ANGLES AND MITIGATES THE NEED FOR MANUAL PROBE POSITIONING. IN THIS PROPOSAL, WE AIM TO FURTHER DEVELOP THE TRANSDUCER TECHNOLOGY, INTERFACING ELECTRONICS, AND IMAGING METHODS TO ENABLE ANGLE-AGNOSTIC FLOW IMAGING IN PHANTOMS, THEN WITH FIRST-IN-HUMAN IMAGING. WE AIM TO ESTABLISH FEASIBILITY DATA FOR FUTURE RESEARCH INTO ADVANCED LONGITUDINAL MONITORING OF CARDIAC OUTPUT, EJECTION FRACTIONS, PULMONARY ARTERY PRESSURE, ETC.

INTERACTION OF CARDIOTONIC DRUGS WITH CARDIAC TROPONIN

ACHIEVING MAXIMUM CRACK REMEDIATION EFFECT FROM OPTIMIZED HYDROTESTING

MECHANISM OF BLAST AND IMPACT ENERGY TRANSFER INTO THE HEAD OF THE HELMETED WARFIGHTER

MULTIPLE SCLEROSIS RESEARCH PROGRAM

GRANT

INTERNAL TISSUES AFFECTED BY SPINAL MANIPULATION

BIOFLUID-BASED DETECTION OF THE MIGRATION SWITCH IN PROSTATE CANCER TO PREDICT METASTATIC DISEASE

CHARACTERIZATION OF A NOVEL MECHANISM OF MERLIN-ASSOCIATED POST-TRANSCRIPTIONAL GENE REGULATION

BOREAL AVIAN MODELLING PROJECT PHASE IV

MECHANISMS OF POST-TRANSCRIPTIONAL REGULATION BY THE TUMOR SUPPRESSOR MERLIN

TOWARDS A BIOMECHANICALLY VALID SIMULANT MODEL OF THE HUMAN CALVARIUM

RECIPIENT NAME: THE GOVERNORS OF THE UNIVERSITY OF ALBERTACOOPERATIVE AGREEMENT NUMBER: G25AC00208PROJECT TITLE: THE ROLE OF DNA METHYLATION IN MORPHOLOGICAL DEFORMITIES IN ARTIFICIALLY REARED CISCOOVERALL PROJECT PERIOD: 04 16 2025 THROUGH 04 15 2030OVERALL BUDGET PERIOD: 04 16 2025 THROUGH 04 15 2026AWARD PURPOSE: THE PURPOSE OF THIS AWARD IS TO INVESTIGATE THE EFFECTS OF DIFFERENT CAPTIVE REARING PROTOCOLS DURING SUPPLEMENTATION AND CONSERVATION EFFORTS ON CISCO (COREGONUS ARTEDI). WE WILL ASSESS HOW DIFFERENT TEMPERATURE REARING PROTOCOLS AFFECT DNA METHYLATION, A MOLECULAR MECHANISM THAT AFFECTS GENE EXPRESSION AND IS OFTEN IMPLICATED AS A MECHANISM FOR THE REDUCED FITNESS AND SURVIVAL OF CAPTIVE-REARED FISH. WE WILL DETERMINE IF SPECIFIC REARING PROTOCOLS MINIMIZE THE UNINTENDED MOLECULAR EFFECTS OF CAPTIVE REARING, LEADING TO THE PRODUCTION OF CAPTIVE CISCO THAT RESEMBLE WILD CISCO AND SURVIVE BETTER IN THE WILD.ACTIVITIES TO BE PERFORMED:CISCO WILL BE SAMPLED FROM DIFFERENT CAPTIVE REARING FACILITIES FOCUSED ON SUPPLEMENTATION OF WILD POPULATIONS, INCLUDING THE JORDAN RIVER HATCHERY AND USGS HAMMOND BAY BIOLOGICAL STATION. SPECIFICALLY, WE WILL SAMPLE CAPTIVE-REARED CISCO REARED IN DIFFERENT THERMAL ENVIRONMENTS, INCLUDING (1) AN OUTDOOR ARTIFICIAL STREAM, (2) A HATCHERY ENVIRONMENT UNDER STANDARD REARING TEMPERATURE FOR FISH PRODUCTION, AND (3) A HATCHERY ENVIRONMENT WITH A NATURAL THERMAL REGIME. WILD CISCO WILL BE SAMPLED FROM SEVERAL NEARBY REGIONS IN LAKE HURON THROUGH COLLABORATION WITH US FISH AND WILDLIFE, THE BAY MILLS INDIAN COMMUNITY, AND THE ONTARIO MINISTRY OF NATURAL RESOURCES. DNA WILL BE EXTRACTED FROM 80 SAMPLES (IDEALLY 40 WILD AND 40 CAPTIVE-REARED CISCO) FOR WHOLE-GENOME ENZYMATIC METHYL-SEQ TO CHARACTERIZE WHOLE-GENOME DIFFERENCES IN METHYLATION AMONG (1) CAPTIVE AND WILD CISCO, AND (2) CISCO FROM DIFFERENT CAPTIVE REARING PROTOCOLS. WE WILL ASSESS HOW DIFFERENCES IN CAPTIVE REARING PROTOCOLS AFFECT DNA METHYLATION, AND WHICH GENES ARE AFFECTED BY DIFFERENT PROTOCOLS. WE WILL ALSO DETERMINE WHETHER SPECIFIC REARING PROTOCOLS LEAD TO CISCO DNA METHYLATION PATTERNS THAT MORE CLOSELY RESEMBLE WILD FISH, WHICH COULD IMPROVE CISCO SURVIVAL AFTER RELEASE INTO THE WILD. WE WILL DETERMINE WHETHER THERE ARE SHARED METHYLATION DIFFERENCES AMONG ALL CAPTIVE REARED CISCO, WHICH COULD SUPPORT THE FUTURE DEVELOPMENT OF EPIGENETIC BIOMARKERS TO DIFFERENTIATE CAPTIVE-REARED AND WILD CISCO BASED ON FIN CLIPS.DELIVERABLES AND EXPECTED OUTCOMES:WE WILL GENERATE WHOLE GENOME DNA METHYLATION DATA FOR CAPTIVE AND WILD CISCO.WE WILL DETERMINE WHETHER THE USE OF DIFFERENT CAPTIVE REARING PROTOCOLS CAN REDUCE THE UNINTENDED EFFECTS OF CAPTIVE REARING ON CISCO DNA METHYLATION, WHICH LIKELY SERVES AS THE MECHANISM FOR THE REDUCED FITNESS OF CAPTIVE-REARED FISH WHEN RELEASED INTO THE WILD.WE WILL TEST FOR CONSISTENT EFFECTS OF CAPTIVE REARING ACROSS DIFFERENT CAPTIVE REARING PROTOCOLS, WHICH WILL SERVE AS A PILOT STUDY TOWARDS THE DEVELOPMENT OF EPIGENETIC BIOMARKERS TO DIFFERENTIATE CAPTIVE-REARED AND WILD FISH.WE EXPECT THAT THESE RESULTS WILL PROVIDE FURTHER INSIGHT INTO THE EFFECTS OF DIFFERENT REARING ENVIRONMENTS ON CAPTIVE-REARED CISCO, WITH THE ULTIMATE GOAL OF PRODUCING MORE NATURAL FISH READY TO FACE NATURE.INTENDED BENEFICIARY(IES): THIS WORK WILL BENEFIT USGS RESEARCH GOALS AND OBJECTIVES IN COREGONINE RESTORATION, INCLUDING UNDERSTANDING THE EFFECTS OF DIFFERENT REARING ENVIRONMENTS ON CISCO, AND THE POTENTIAL FOR EPIGENETIC BIOMARKERS TO NONLETHALLY IDENTIFY ARTIFICIALLY REARED CISCO. THE RESULTS WILL ALSO BE SHARED WITH INTERESTED STAKEHOLDERS, INCLUDING THE JORDAN RIVER HATCHERY AND OTHERS INVOLVED IN COREGONINE RESTORATION IN THE GREAT LAKES.

INVESTIGATING MUC1/ICAM-1 BINDING INDUCED SIGNALING IN BREAST CANCER METASTASIS

SPLICING FACTOR KINASE SRPK1 REGULATES METASTATIC DISSEMINATION OF HUMAN PROSTATE CANCER

AWARD TO BE USED TO FUND SPEAKERS' ACCOMODATIONS EQUIPMENT AND FACILITIES RENTAL. THE INSTITUTE IS THE ONLY U.S. ORIENTED RESEARCH INSTITUE IN THE P

INTERNATIONAL CONFERENCE ON PIG REPRODUCTION