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Source: IRS Form 990 via ProPublica Nonprofit Explorer
Total Revenue
▼$1.5B
Total Contributions
$823.9M
Total Expenses
▼$1.4B
Total Assets
$4.7B
Total Liabilities
▼$2.7B
Net Assets
$2B
Officer Compensation
→$2.8M
Other Salaries
$695.4M
Investment Income
▼$182.8M
Fundraising
▼$0
Source: USAspending.gov · Searched by organization name
VA/DoD Awards
$9.8M
VA/DoD Award Count
16
Funding from the Department of Veterans Affairs and/or Department of Defense.
Total Federal Funding
$30.1M
Awards Found
41
| Awarding Agency | Description | Amount | Fiscal Year | Period |
|---|---|---|---|---|
| VA/DoDDepartment of Defense | PLACEBO CONTROLLED, DOUBLE-BLIND STUDY TO EVALUATE THE EFFICACY, SAFETY, AND TOLERABILITY OF SCX-001 CREAM IN BURN PATIENTS WITH STANDARDIZED DEEP DERMAL INCISIONS...NEW COOPERATIVE AGREEMENT, SIGNED ON 9/6/2019, EFFECTIVE 9/30/2019, DISTRIBUTED 9/6/2019, FAADC 9/10/2019 | $3.5M | FY2019 | Sep 2019 – Sep 2026 |
| Department of Health and Human Services | LINKING ISLET CELL FUNCTION AND IDENTITY FROM IN VITRO TO IN SITU | $3M | FY2018 | Sep 2018 – Jun 2023 |
| Department of Health and Human Services | MOTONEURON PROPERTIES IN CHRONIC SPINAL INJURY | $3M | FY2004 | Sep 2004 – Jan 2022 |
| Department of Health and Human Services | IMPACT OF EXERCISE ON SARCOPENIA | $2.1M | FY2009 | May 2009 – Apr 2015 |
| Department of Health and Human Services | EXPLOITING CROSS-REACTIVE, CONSERVED EPITOPES IN PLASMODIUM VIVAX TO DEVELOP A VACCINE AGAINST FALCIPARUM PLACENTAL MALARIA. | $1.9M | FY2020 | Mar 2020 – Feb 2026 |
| Department of Health and Human Services | LONGITUDINAL STUDY OF COGNITIVE AGING | $1.8M | FY1989 | Aug 1989 – May 2019 |
| VA/DoDDepartment of Defense | OPTIMIZING TRANSHUMERAL OSSEOINTEGRATION PROSTHESIS CONTROL | $1.5M | FY2023 | Sep 2023 – Aug 2027 |
| VA/DoDDepartment of Defense | PRECLINICAL TESTING OF INTRASPINAL MICROSTIMULATION FOR RESTORING WALKING AFTER SEVERE SCI. NEW AWARD. | $1.5M | FY2020 | Sep 2020 – Sep 2025 |
| Department of Health and Human Services | ROLE OF CD22 IN THE GERMINAL CENTER REACTION | $1.4M | FY2017 | Sep 2017 – Aug 2023 |
| VA/DoDDepartment of Defense | AN INNOVATIVE APPROACH FOR NONINVASIVE EVALUATION OF STABILITY AT THE IMPLANT-BONE INTERFACE FOR TRANSFEMORAL OSSEOINTEGRATED IMPLANTS | $1.2M | FY2021 | Sep 2021 – Sep 2026 |
| Department of Health and Human Services | MECHANISMS OF ISLET FAILURE IN CF - PROJECT SUMMARY DIABETES IS A MAJOR CO-MORBIDITY OF CYSTIC FIBROSIS (CF), AFFECTING 20% OF ADOLESCENTS AND 40-50% OF ADULTS WITH CF. CF-RELATED DIABETES (CFRD) IS ASSOCIATED WITH WORSE DISEASE OUTCOMES AND A 4-FOLD INCREASE IN MORTALITY RELATIVE TO CF PATIENTS WITHOUT DIABETES. IMPAIRED INSULIN RELEASE IS THE KEY DEFECT UNDERLYING CFRD, BUT ITS ETIOLOGY IS POORLY UNDERSTOOD. PANCREATIC DUCTAL EPITHELIAL CELLS (PDECS) ARE THE MAJOR SOURCE OF PANCREATIC CFTR AND ARE THE INITIATING SITE OF CF PANCREAS PATHOLOGY, WHICH LEADS TO DESTRUCTION OF PANCREATIC ACINI (IN 85% OF CF CASES). ISLETS ARE RELATIVELY PRESERVED IN THE CF PANCREAS. HOWEVER, ISLET MORPHOLOGY IS PROFOUNDLY ALTERED, INCLUDING INCREASED Α CELLS (ALTHOUGH GLUCAGON RELEASE IS IMPAIRED IN CF), AND LOSS OF ISLET CAPILLARIES AND MACROPHAGES. THESE CELL TYPES SUPPORT NORMAL Β CELL FUNCTION AND SO THEIR DISRUPTION IN CF LIKELY CONTRIBUTES TO INSULIN DEFICIENCY. RECENT STUDIES, INCLUDING OUR PRELIMINARY DATA, SHOW THAT KNOCKDOWN/INHIBITION OF CFTR IN PDECS CAN INDUCE ISLET DYSFUNCTION (IMPAIRED INSULIN RELEASE). HOWEVER, THE RELATIVE CONTRIBUTION OF DIRECT PDEC-ISLET EFFECTS VS. THOSE OCCURRING INDIRECTLY VIA PANCREATIC ACINAR CELLS OR OTHER ISLET CELLS ARE UNKNOWN. MOREOVER, THE UNDERLYING MECHANISMS ARE ENTIRELY UNEXPLORED. WE HYPOTHESIZE THAT CFTR-DEFECTIVE HUMAN PDECS EXERT DETRIMENTAL EFFECTS ON Β CELLS, BOTH DIRECTLY AND INDIRECTLY, TO IMPAIR INSULIN RELEASE AND Β CELL HEALTH. WE WILL PERFORM STUDIES IN PRIMARY HUMAN CELLS (PDECS, ISLET Β-CELLS, Α- CELLS, ACINAR CELLS, ISLET ENDOTHELIAL CELLS AND MACROPHAGES). WE WILL ALSO USE CF DONOR PLURIPOTENT STEM CELL (PSC)-DERIVED PDECS. SPECIFIC AIM 1: TO DETERMINE WHETHER CFTR-DEFECTIVE PDECS IMPAIR INSULIN RELEASE VIA DIRECT EFFECTS ON ISLET Β-CELLS. TRANSCRIPTOMIC AND PROTEOMIC ANALYSIS WILL BE DONE ON PDECS AND PDEC-DERIVED EXTRACELLULAR VESICLES USING PRIMARY OR HPSC-DERIVED PDECS ± CFTR MUTATIONS. FROM THESE DATA, WE WILL IDENTIFY KEY PATHWAYS THAT MEDIATE CROSS TALK BETWEEN PDECS AND Β CELLS. THE IMPACT OF THOSE PATHWAYS WILL THEN BE TESTED IN INTERVENTION STUDIES USING ISLETS AND PRIMARY HUMAN Β CELLS. SPECIFIC AIM 2: TO DETERMINE WHETHER CFTR-DEFECTIVE PDECS IMPAIR INSULIN RELEASE INDIRECTLY. WE WILL RECAPITULATE THE KNOWN TOXIC EFFECTS OF CFTR-DEFECTIVE PDECS ON ACINAR CELLS USING AN IN VITRO SYSTEM AND DETERMINE WHETHER ACINAR ELICITED FACTORS CAN THEMSELVES IMPAIR Β CELL FUNCTION. NEXT, WE WILL SYSTEMATICALLY INTERROGATE THE EFFECT OF CFTR-DEFECTIVE PDECS AND/OR ACINAR CELLS PREVIOUSLY EXPOSED TO THOSE PDECS ON THE FUNCTION, IDENTITY AND VIABILITY OF ISLET Α CELLS, ENDOTHELIAL CELLS AND MACROPHAGES. SPECIFIC AIM 3: EFFECT OF PDEC-CFTR KNOCKDOWN ON INSULIN RELEASE IN HUMAN PANCREAS SLICES. PANCREAS SLICES, WHICH PRESERVE THE 3D ARRANGEMENT OF PANCREATIC CELL TYPES, WILL BE USED TO DETERMINE THE EFFECT OF PDEC-CFTR LOSS ON INSULIN RELEASE OVER TIME, ALONG WITH CONCURRENT MEASUREMENT OF THE VIABILITY/FUNCTION OF ACINAR CELLS AND Α-CELLS ALONG WITH MORPHOLOGICAL CHANGES IN ISLET ENDOTHELIAL CELLS AND MACROPHAGES. | $870.8K | FY2024 | Sep 2024 – Jul 2029 |
| Department of Health and Human Services | LONGITUDINAL STUDY OF COGNITIVE AGING | $859.6K | FY1989 | Aug 1989 – Jul 2012 |
| Department of Health and Human Services | PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS | $777.4K | FY2008 | Sep 2008 – Jun 2012 |
| Department of Health and Human Services | INTRASPINAL MICROSTIMULATION FOR RESTORING LIMB MOVEMENT | $740.4K | FY2002 | Sep 2002 – Jan 2014 |
| Department of Health and Human Services | RECOVERY OF MOTONEURON EXCITABILITY AFTER SPINAL INJURY | $673.6K | FY2006 | Aug 2006 – Jan 2011 |
| VA/DoDDepartment of Defense | EVALUATION OF A NOVEL T CELL-DERIVED PEPTIDE FOR DELIVERY OF ANTISENSE OLIGONUCLEOTIDES TO TREAT DMD CARDIOMYOPATHY | $429.3K | FY2022 | Sep 2022 – Sep 2025 |
| VA/DoDDepartment of Defense | STUDIES ON THE DYNAMIC FAILURE OF DAMAGED AND GRANULAR BRITTLE MATERIALS | $423.8K | FY2017 | Sep 2017 – Nov 2022 |
| Department of Health and Human Services | ISLET TRANSPLANT - COSTIMULATORY BLOCKADE WITH LEA29Y | $378K | FY2004 | Sep 2004 – Aug 2012 |
| Department of Health and Human Services | ULTRASENSITIVE BISPECIFIC ANTIBODY ASSAY FOR SARS VIRUS | $358.9K | FY2005 | Mar 2005 – Feb 2011 |
| Department of Health and Human Services | ROLE OF SIGLEC-10/G AS A TUMOR SUPPRESSOR IN B-CELLS | $354.2K | FY2017 | Jan 2017 – Dec 2018 |
| Department of Health and Human Services | PARKINSON DISEASE NEUROPROTECTION TRIAL: CLINICAL CENTER | $324.2K | FY2002 | Sep 2002 – Nov 2014 |
| Department of Health and Human Services | HIGH FREQUENCY WEARABLE AND TRANSPARENT ELECTROSTRICTIVE ROW-COLUMN ARRAYS FOR WHOLE BRAIN FUNCTIONAL IMAGING - PROJECT SUMMARY/ABSTRACT SECTION ENTER THE TEXT HERE THAT IS THE NEW ABSTRACT INFORMATION FOR YOUR APPLICATION. THIS SECTION MUST BE NO LONGER THAN 30 LINES OF TEXT. WE PROPOSE THE DEVELOPMENT OF A NOVEL BIAS-SWITCHABLE ROW-COLUMN 2D ULTRASOUND TRANSDUCER ARRAY TECHNOLOGY FOR 3D ULTRASOUND AND PHOTOACOUSTIC IMAGING OF WHOLE-BRAIN FUNCTIONAL ACTIVITY WITH POTENTIAL FOR A WEARABLE FORMAT FOR AWAKE AND MOVING ANIMALS. THESE CAN BE DEVELOPED INTO HIGH- FREQUENCY ARRAYS AND EVEN TRANSPARENT VARIANTS THAT SHOULD ALLOW OPTICAL AND ULTRASONIC IMAGING DOWN TO RESOLUTIONS OF 30 MICRONS, APPROACHING SINGLE-NEURON SCALES. UNLIKE PREVIOUS 2D ARRAY TECHNOLOGIES THAT REQUIRE WIRES CONNECTING TO EACH TRANSDUCER ELEMENT, OUR APPROACH REQUIRES ONLY ROW- AND COLUMN ADDRESSING, YET PERMITS READOUT FROM EVERY ELEMENT OF THE ARRAY USING NOVEL ELECTROSTRICTIVE BIAS SWITCHING APPROACHES. THE TECHNOLOGY PROMISES FIRST-OF-IT’S KIND VOLUMETRIC FUNCTIONAL BRAIN IMAGING OF BLOOD-FLOW CHANGES, BLOOD OXYGENATION CHANGES, AND EVEN NEURON ACTIVITY OVER THE WHOLE BRAINS OF AWAKE AND MOVING RODENTS. THE ARRAY OFFERS SIGNIFICANT POTENTIAL FOR NEXT-GENERATION NEUROSCIENCE EXPERIMENTS INVOLVING BOTH OPTICAL AND ACOUSTIC METHODS, INCLUDING FUTURE WORK COMBINING FUNCTIONAL ULTRASOUND AND PHOTOACOUSTIC IMAGING WITH OPTOGENETICS, OPTICAL MICROSCOPY OF GENETICALLY-ENCODED REPORTERS OF NEURON ACTIVITY, ULTRASOUND NEURO-STIMULATION, ULTRASOUND BLOOD-BRAIN BARRIER DISRUPTION FOR DRUG DELIVERY, AND MORE. THE ARRAYS HAVE CONSIDERABLE TRANSLATIONAL POTENTIAL FOR FUTURE HUMAN SUBJECT IMAGING IN NEUROSURGERIES, NEONATES, AND WITH POTENTIAL FOR IMPLANTABLE DEVICES FOR LONGITUDINAL FUNCTIONAL BRAIN IMAGING. OUR RESEARCH METHODS INCLUDE CAREFUL DESIGN AND FABRICATION OF THESE HIGH-FREQUENCY ARRAYS WITH SPECIAL ATTENTION TO TRANSPARENT VARIANTS. WE ALSO DEVELOP NOVEL IMAGING SCHEMES AND IMPLEMENT THESE SCHEMES ON PROGRAMMABLE ULTRASOUND SYSTEMS. TESTING WILL INCLUDE ARRAY CHARACTERIZATION, IMAGING PHANTOMS, IMAGING CELLS EXPRESSING NEAR-INFRARED (NIR) GENETICALLY-ENCODED REPORTERS OF NEURON CALCIUM ACTIVITY. IF SUCCESSFUL, FUTURE WORK WILL GO ON TO IMPLEMENT ANIMAL IMAGING EXPERIMENTS AIMING TO VISUALIZE FUNCTIONAL BRAIN IMAGING DUE TO WHISKER STIMULATION IN BOTH ANESTHETIZED AND AWAKE- MOVING ANIMALS. | $323.9K | FY2021 | Sep 2021 – Aug 2024 |
| Department of Health and Human Services | ALBERTA PREGNANCY OUTCOMES AND NUTRITION (APRON) - TOXICANT-DIET INTERACTIONS ON | $320.4K | FY2012 | Jun 2012 – May 2015 |
| VA/DoDDepartment of Defense | DYNAMIC FAILURE AND FRAGMENTATION OF ADVANCED CERAMICS 1: COMPRESSION AND IMPACT EXPERIMENTS | $300K | FY2016 | Jul 2016 – Jul 2020 |
| Department of Health and Human Services | WEARABLE ELECTROSTRICTIVE ROW-COLUMN ULTRASOUND ARRAYS FOR LONGITUDINAL ECHOCARDIOGRAPHY - PROJECT SUMMARY / ABSTRACT IN PATIENTS ADMITTED TO INTENSIVE CARE UNITS (ICUS) WITH SHOCK (LOW BLOOD PRESSURE) THAT RESULTS IN BOTH CLINICAL AND BIOCHEMICAL EVIDENCE OF TISSUE HYPOPERFUSION DUE TO INADEQUATE CARDIAC OUTPUT, CLINICIANS COMMONLY SEEK TO ASSESS AND MONITOR CARDIAC FUNCTION, BUT ALL AVAILABLE INVASIVE AND NON-INVASIVE METHODOLOGIES HAVE SIGNIFICANT LIMITATIONS AND/OR RISK. THE GOLD STANDARD METHOD TO ASSESS CARDIAC OUTPUT AND SHOCK STATES IS A PULMONARY ARTERIAL CATHETER (PAC) WHICH IS INSERTED THROUGH A VENOUS CANULA AND PASSES THROUGH THE RIGHT SIDE OF THE HEART INTO THE PULMONARY ARTERY. THE ADVANTAGES OF THIS MODALITY ARE THAT IT PROVIDES INFORMATION ON RIGHT AND LEFT HEART PRESSURES, AND ALLOWS FOR THE CALCULATION OF CARDIAC OUTPUT VIA THERMODILUTION TECHNIQUES. ITS DISADVANTAGES INCLUDE THE INVASIVE NATURE RESULTING THE POTENTIAL RISK OF VASCULAR INJURY. MOREOVER, CARDIAC OUTPUTS ARE INACCURATE IN COMMON CARDIAC ARRHYTHMIAS (EX ATRIAL FIBRILLATION) AND VALVULAR LESIONS (EX TRICUSPID REGURGITATION), AND ONLY PROVIDES INFORMATION ON OVERALL CARDIAC FUNCTION WITHOUT DIRECT INFORMATION ON LEFT AND RIGHT HEART FUNCTION. NON-INVASIVE CARDIAC OUTPUT MONITORS (NICOMS) USE PROPRIETARY BIO-IMPEDANCE OR ARTERIAL LINE AREA UNDER THE CURVE ALGORITHMS TO ESTIMATE CARDIAC OUTPUT. WHILE THESE ARE MINIMALLY INVASIVE, THEY HAVE NOT BEEN WELL VALIDATED IN PATIENTS IN CARDIOGENIC SHOCK AND PROVIDE NO INFORMATION ON LEFT AND RIGHT HEART FUNCTION. FINALLY, POINT OF CARE ULTRASOUND (POCUS) ALLOWS ECHOCARDIOGRAPHIC EVALUATION OF LEFT AND RIGHT HEART FUNCTION, BUT IT IS NOT WELL SUITED FOR EVALUATION OF CONTINUOUS OR TEMPORAL TRENDS IN CARDIAC FUNCTION GIVEN IT REQUIRES A CLINICIAN TO ACQUIRE IMAGES AT THE BEDSIDE. A WEARABLE ULTRASOUND PROBE THAT WOULD ENABLE HANDS-FREE LONGITUDINAL IMAGING OF PATIENTS WOULD PROVE TO BE OF CONSIDERABLE VALUE IN THE ICU ENVIRONMENT. IN THIS PROPOSAL WE INTRODUCE A RADICALLY NEW WEARABLE ULTRASOUND TECHNOLOGY, BIAS-SENSITIVE ELECTROSTRICTIVE TOP- ORTHOGONAL-TO-BOTTOM ELECTRODE (TOBE) ARRAYS. THESE TOBE ARRAYS OFFER READOUT FROM EVERY ELEMENT OF A 2D ARRAY THROUGH BIASING CONTROL AND TRANSMIT-RECEIVE CONTROL OF ONLY ROWS AND COLUMNS, RATHER THAN REQUIRE WIRING FROM EVERY ELEMENT. WITH NOVEL READOUT APPROACHES, THESE ARRAYS WILL BE DEMONSTRATED TO ACHIEVE IMAGE QUALITY COMPARABLE TO A LINEAR ARRAY, BUT WITH FULL ELECTRONIC 3D SCANNING CAPABILITIES. UNLIKE MATRIX PROBES THAT RELY ON COMPLICATED MICRO-BEAMFORMERS, OUR APPROACH IS SIMPLER, YET ALLOWS FOR ADVANCED IMAGING MODES SUCH AS ULTRAFAST IMAGING AT THOUSANDS OF FRAMES PER SECOND. WE PROPOSE THE DEVELOPMENT OF SUCH ULTRAFAST IMAGING MODES WITH WEARABLE TOBE PROBES FOR ANGLE-AGNOSTIC FLOW ESTIMATION AND LONGITUDINAL ELECTRONIC TRACKING OF RIGHT AND LEFT HEART FUNCTION. THE ANGLE-AGNOSTIC FLOW ESTIMATION AVOIDS ERRORS DUE TO UNKNOWN DOPPLER ANGLES AND MITIGATES THE NEED FOR MANUAL PROBE POSITIONING. IN THIS PROPOSAL, WE AIM TO FURTHER DEVELOP THE TRANSDUCER TECHNOLOGY, INTERFACING ELECTRONICS, AND IMAGING METHODS TO ENABLE ANGLE-AGNOSTIC FLOW IMAGING IN PHANTOMS, THEN WITH FIRST-IN-HUMAN IMAGING. WE AIM TO ESTABLISH FEASIBILITY DATA FOR FUTURE RESEARCH INTO ADVANCED LONGITUDINAL MONITORING OF CARDIAC OUTPUT, EJECTION FRACTIONS, PULMONARY ARTERY PRESSURE, ETC. | $297K | FY2022 | Apr 2022 – Mar 2025 |
| Department of Health and Human Services | INTERACTION OF CARDIOTONIC DRUGS WITH CARDIAC TROPONIN | $262.2K | FY2006 | Aug 2006 – Jul 2010 |
| Department of Transportation | ACHIEVING MAXIMUM CRACK REMEDIATION EFFECT FROM OPTIMIZED HYDROTESTING | $240K | FY2008 | Jun 2008 – Jun 2011 |
| VA/DoDDepartment of Defense | MECHANISM OF BLAST AND IMPACT ENERGY TRANSFER INTO THE HEAD OF THE HELMETED WARFIGHTER | $216K | FY2016 | Jun 2016 – May 2019 |
| VA/DoDDepartment of Defense | MULTIPLE SCLEROSIS RESEARCH PROGRAM | $196.8K | FY2021 | Sep 2021 – Aug 2024 |
| VA/DoDDepartment of Defense | GRANT | $149.6K | FY2022 | Aug 2022 – May 2025 |
| Department of Health and Human Services | INTERNAL TISSUES AFFECTED BY SPINAL MANIPULATION | $132.7K | FY2008 | Aug 2008 – May 2011 |
| VA/DoDDepartment of Defense | BIOFLUID-BASED DETECTION OF THE MIGRATION SWITCH IN PROSTATE CANCER TO PREDICT METASTATIC DISEASE | $120.5K | FY2015 | Aug 2015 – Aug 2017 |
| VA/DoDDepartment of Defense | CHARACTERIZATION OF A NOVEL MECHANISM OF MERLIN-ASSOCIATED POST-TRANSCRIPTIONAL GENE REGULATION | $99.7K | FY2016 | Jun 2016 – May 2018 |
| Department of the Interior | BOREAL AVIAN MODELLING PROJECT PHASE IV | $98.8K | FY2013 | Sep 2013 – Sep 2015 |
| VA/DoDDepartment of Defense | MECHANISMS OF POST-TRANSCRIPTIONAL REGULATION BY THE TUMOR SUPPRESSOR MERLIN | $86.5K | FY2008 | Feb 2008 – Mar 2009 |
| VA/DoDDepartment of Defense | TOWARDS A BIOMECHANICALLY VALID SIMULANT MODEL OF THE HUMAN CALVARIUM | $82.4K | FY2020 | Oct 2019 – Dec 2020 |
| Department of the Interior | RECIPIENT NAME: THE GOVERNORS OF THE UNIVERSITY OF ALBERTACOOPERATIVE AGREEMENT NUMBER: G25AC00208PROJECT TITLE: THE ROLE OF DNA METHYLATION IN MORPHOLOGICAL DEFORMITIES IN ARTIFICIALLY REARED CISCOOVERALL PROJECT PERIOD: 04 16 2025 THROUGH 04 15 2030OVERALL BUDGET PERIOD: 04 16 2025 THROUGH 04 15 2026AWARD PURPOSE: THE PURPOSE OF THIS AWARD IS TO INVESTIGATE THE EFFECTS OF DIFFERENT CAPTIVE REARING PROTOCOLS DURING SUPPLEMENTATION AND CONSERVATION EFFORTS ON CISCO (COREGONUS ARTEDI). WE WILL ASSESS HOW DIFFERENT TEMPERATURE REARING PROTOCOLS AFFECT DNA METHYLATION, A MOLECULAR MECHANISM THAT AFFECTS GENE EXPRESSION AND IS OFTEN IMPLICATED AS A MECHANISM FOR THE REDUCED FITNESS AND SURVIVAL OF CAPTIVE-REARED FISH. WE WILL DETERMINE IF SPECIFIC REARING PROTOCOLS MINIMIZE THE UNINTENDED MOLECULAR EFFECTS OF CAPTIVE REARING, LEADING TO THE PRODUCTION OF CAPTIVE CISCO THAT RESEMBLE WILD CISCO AND SURVIVE BETTER IN THE WILD.ACTIVITIES TO BE PERFORMED:CISCO WILL BE SAMPLED FROM DIFFERENT CAPTIVE REARING FACILITIES FOCUSED ON SUPPLEMENTATION OF WILD POPULATIONS, INCLUDING THE JORDAN RIVER HATCHERY AND USGS HAMMOND BAY BIOLOGICAL STATION. SPECIFICALLY, WE WILL SAMPLE CAPTIVE-REARED CISCO REARED IN DIFFERENT THERMAL ENVIRONMENTS, INCLUDING (1) AN OUTDOOR ARTIFICIAL STREAM, (2) A HATCHERY ENVIRONMENT UNDER STANDARD REARING TEMPERATURE FOR FISH PRODUCTION, AND (3) A HATCHERY ENVIRONMENT WITH A NATURAL THERMAL REGIME. WILD CISCO WILL BE SAMPLED FROM SEVERAL NEARBY REGIONS IN LAKE HURON THROUGH COLLABORATION WITH US FISH AND WILDLIFE, THE BAY MILLS INDIAN COMMUNITY, AND THE ONTARIO MINISTRY OF NATURAL RESOURCES. DNA WILL BE EXTRACTED FROM 80 SAMPLES (IDEALLY 40 WILD AND 40 CAPTIVE-REARED CISCO) FOR WHOLE-GENOME ENZYMATIC METHYL-SEQ TO CHARACTERIZE WHOLE-GENOME DIFFERENCES IN METHYLATION AMONG (1) CAPTIVE AND WILD CISCO, AND (2) CISCO FROM DIFFERENT CAPTIVE REARING PROTOCOLS. WE WILL ASSESS HOW DIFFERENCES IN CAPTIVE REARING PROTOCOLS AFFECT DNA METHYLATION, AND WHICH GENES ARE AFFECTED BY DIFFERENT PROTOCOLS. WE WILL ALSO DETERMINE WHETHER SPECIFIC REARING PROTOCOLS LEAD TO CISCO DNA METHYLATION PATTERNS THAT MORE CLOSELY RESEMBLE WILD FISH, WHICH COULD IMPROVE CISCO SURVIVAL AFTER RELEASE INTO THE WILD. WE WILL DETERMINE WHETHER THERE ARE SHARED METHYLATION DIFFERENCES AMONG ALL CAPTIVE REARED CISCO, WHICH COULD SUPPORT THE FUTURE DEVELOPMENT OF EPIGENETIC BIOMARKERS TO DIFFERENTIATE CAPTIVE-REARED AND WILD CISCO BASED ON FIN CLIPS.DELIVERABLES AND EXPECTED OUTCOMES:WE WILL GENERATE WHOLE GENOME DNA METHYLATION DATA FOR CAPTIVE AND WILD CISCO.WE WILL DETERMINE WHETHER THE USE OF DIFFERENT CAPTIVE REARING PROTOCOLS CAN REDUCE THE UNINTENDED EFFECTS OF CAPTIVE REARING ON CISCO DNA METHYLATION, WHICH LIKELY SERVES AS THE MECHANISM FOR THE REDUCED FITNESS OF CAPTIVE-REARED FISH WHEN RELEASED INTO THE WILD.WE WILL TEST FOR CONSISTENT EFFECTS OF CAPTIVE REARING ACROSS DIFFERENT CAPTIVE REARING PROTOCOLS, WHICH WILL SERVE AS A PILOT STUDY TOWARDS THE DEVELOPMENT OF EPIGENETIC BIOMARKERS TO DIFFERENTIATE CAPTIVE-REARED AND WILD FISH.WE EXPECT THAT THESE RESULTS WILL PROVIDE FURTHER INSIGHT INTO THE EFFECTS OF DIFFERENT REARING ENVIRONMENTS ON CAPTIVE-REARED CISCO, WITH THE ULTIMATE GOAL OF PRODUCING MORE NATURAL FISH READY TO FACE NATURE.INTENDED BENEFICIARY(IES): THIS WORK WILL BENEFIT USGS RESEARCH GOALS AND OBJECTIVES IN COREGONINE RESTORATION, INCLUDING UNDERSTANDING THE EFFECTS OF DIFFERENT REARING ENVIRONMENTS ON CISCO, AND THE POTENTIAL FOR EPIGENETIC BIOMARKERS TO NONLETHALLY IDENTIFY ARTIFICIALLY REARED CISCO. THE RESULTS WILL ALSO BE SHARED WITH INTERESTED STAKEHOLDERS, INCLUDING THE JORDAN RIVER HATCHERY AND OTHERS INVOLVED IN COREGONINE RESTORATION IN THE GREAT LAKES. | $78.6K | FY2025 | Apr 2025 – Apr 2030 |
| VA/DoDDepartment of Defense | INVESTIGATING MUC1/ICAM-1 BINDING INDUCED SIGNALING IN BREAST CANCER METASTASIS | $41.9K | FY2010 | May 2010 – Aug 2011 |
| VA/DoDDepartment of Defense | SPLICING FACTOR KINASE SRPK1 REGULATES METASTATIC DISSEMINATION OF HUMAN PROSTATE CANCER | $40.3K | FY2015 | Aug 2015 – Aug 2017 |
| Department of State | AWARD TO BE USED TO FUND SPEAKERS' ACCOMODATIONS EQUIPMENT AND FACILITIES RENTAL. THE INSTITUTE IS THE ONLY U.S. ORIENTED RESEARCH INSTITUE IN THE P | $13.5K | FY2010 | Sep 2010 – Apr 2011 |
| Department of Agriculture | INTERNATIONAL CONFERENCE ON PIG REPRODUCTION | $7,380 | FY2009 | May 2009 – Sep 2009 |
Department of Defense
$3.5M
PLACEBO CONTROLLED, DOUBLE-BLIND STUDY TO EVALUATE THE EFFICACY, SAFETY, AND TOLERABILITY OF SCX-001 CREAM IN BURN PATIENTS WITH STANDARDIZED DEEP DERMAL INCISIONS...NEW COOPERATIVE AGREEMENT, SIGNED ON 9/6/2019, EFFECTIVE 9/30/2019, DISTRIBUTED 9/6/2019, FAADC 9/10/2019
Department of Health and Human Services
$3M
LINKING ISLET CELL FUNCTION AND IDENTITY FROM IN VITRO TO IN SITU
Department of Health and Human Services
$3M
MOTONEURON PROPERTIES IN CHRONIC SPINAL INJURY
Department of Health and Human Services
$2.1M
IMPACT OF EXERCISE ON SARCOPENIA
Department of Health and Human Services
$1.9M
EXPLOITING CROSS-REACTIVE, CONSERVED EPITOPES IN PLASMODIUM VIVAX TO DEVELOP A VACCINE AGAINST FALCIPARUM PLACENTAL MALARIA.
Department of Health and Human Services
$1.8M
LONGITUDINAL STUDY OF COGNITIVE AGING
Department of Defense
$1.5M
OPTIMIZING TRANSHUMERAL OSSEOINTEGRATION PROSTHESIS CONTROL
Department of Defense
$1.5M
PRECLINICAL TESTING OF INTRASPINAL MICROSTIMULATION FOR RESTORING WALKING AFTER SEVERE SCI. NEW AWARD.
Department of Health and Human Services
$1.4M
ROLE OF CD22 IN THE GERMINAL CENTER REACTION
Department of Defense
$1.2M
AN INNOVATIVE APPROACH FOR NONINVASIVE EVALUATION OF STABILITY AT THE IMPLANT-BONE INTERFACE FOR TRANSFEMORAL OSSEOINTEGRATED IMPLANTS
Department of Health and Human Services
$870.8K
MECHANISMS OF ISLET FAILURE IN CF - PROJECT SUMMARY DIABETES IS A MAJOR CO-MORBIDITY OF CYSTIC FIBROSIS (CF), AFFECTING 20% OF ADOLESCENTS AND 40-50% OF ADULTS WITH CF. CF-RELATED DIABETES (CFRD) IS ASSOCIATED WITH WORSE DISEASE OUTCOMES AND A 4-FOLD INCREASE IN MORTALITY RELATIVE TO CF PATIENTS WITHOUT DIABETES. IMPAIRED INSULIN RELEASE IS THE KEY DEFECT UNDERLYING CFRD, BUT ITS ETIOLOGY IS POORLY UNDERSTOOD. PANCREATIC DUCTAL EPITHELIAL CELLS (PDECS) ARE THE MAJOR SOURCE OF PANCREATIC CFTR AND ARE THE INITIATING SITE OF CF PANCREAS PATHOLOGY, WHICH LEADS TO DESTRUCTION OF PANCREATIC ACINI (IN 85% OF CF CASES). ISLETS ARE RELATIVELY PRESERVED IN THE CF PANCREAS. HOWEVER, ISLET MORPHOLOGY IS PROFOUNDLY ALTERED, INCLUDING INCREASED Α CELLS (ALTHOUGH GLUCAGON RELEASE IS IMPAIRED IN CF), AND LOSS OF ISLET CAPILLARIES AND MACROPHAGES. THESE CELL TYPES SUPPORT NORMAL Β CELL FUNCTION AND SO THEIR DISRUPTION IN CF LIKELY CONTRIBUTES TO INSULIN DEFICIENCY. RECENT STUDIES, INCLUDING OUR PRELIMINARY DATA, SHOW THAT KNOCKDOWN/INHIBITION OF CFTR IN PDECS CAN INDUCE ISLET DYSFUNCTION (IMPAIRED INSULIN RELEASE). HOWEVER, THE RELATIVE CONTRIBUTION OF DIRECT PDEC-ISLET EFFECTS VS. THOSE OCCURRING INDIRECTLY VIA PANCREATIC ACINAR CELLS OR OTHER ISLET CELLS ARE UNKNOWN. MOREOVER, THE UNDERLYING MECHANISMS ARE ENTIRELY UNEXPLORED. WE HYPOTHESIZE THAT CFTR-DEFECTIVE HUMAN PDECS EXERT DETRIMENTAL EFFECTS ON Β CELLS, BOTH DIRECTLY AND INDIRECTLY, TO IMPAIR INSULIN RELEASE AND Β CELL HEALTH. WE WILL PERFORM STUDIES IN PRIMARY HUMAN CELLS (PDECS, ISLET Β-CELLS, Α- CELLS, ACINAR CELLS, ISLET ENDOTHELIAL CELLS AND MACROPHAGES). WE WILL ALSO USE CF DONOR PLURIPOTENT STEM CELL (PSC)-DERIVED PDECS. SPECIFIC AIM 1: TO DETERMINE WHETHER CFTR-DEFECTIVE PDECS IMPAIR INSULIN RELEASE VIA DIRECT EFFECTS ON ISLET Β-CELLS. TRANSCRIPTOMIC AND PROTEOMIC ANALYSIS WILL BE DONE ON PDECS AND PDEC-DERIVED EXTRACELLULAR VESICLES USING PRIMARY OR HPSC-DERIVED PDECS ± CFTR MUTATIONS. FROM THESE DATA, WE WILL IDENTIFY KEY PATHWAYS THAT MEDIATE CROSS TALK BETWEEN PDECS AND Β CELLS. THE IMPACT OF THOSE PATHWAYS WILL THEN BE TESTED IN INTERVENTION STUDIES USING ISLETS AND PRIMARY HUMAN Β CELLS. SPECIFIC AIM 2: TO DETERMINE WHETHER CFTR-DEFECTIVE PDECS IMPAIR INSULIN RELEASE INDIRECTLY. WE WILL RECAPITULATE THE KNOWN TOXIC EFFECTS OF CFTR-DEFECTIVE PDECS ON ACINAR CELLS USING AN IN VITRO SYSTEM AND DETERMINE WHETHER ACINAR ELICITED FACTORS CAN THEMSELVES IMPAIR Β CELL FUNCTION. NEXT, WE WILL SYSTEMATICALLY INTERROGATE THE EFFECT OF CFTR-DEFECTIVE PDECS AND/OR ACINAR CELLS PREVIOUSLY EXPOSED TO THOSE PDECS ON THE FUNCTION, IDENTITY AND VIABILITY OF ISLET Α CELLS, ENDOTHELIAL CELLS AND MACROPHAGES. SPECIFIC AIM 3: EFFECT OF PDEC-CFTR KNOCKDOWN ON INSULIN RELEASE IN HUMAN PANCREAS SLICES. PANCREAS SLICES, WHICH PRESERVE THE 3D ARRANGEMENT OF PANCREATIC CELL TYPES, WILL BE USED TO DETERMINE THE EFFECT OF PDEC-CFTR LOSS ON INSULIN RELEASE OVER TIME, ALONG WITH CONCURRENT MEASUREMENT OF THE VIABILITY/FUNCTION OF ACINAR CELLS AND Α-CELLS ALONG WITH MORPHOLOGICAL CHANGES IN ISLET ENDOTHELIAL CELLS AND MACROPHAGES.
Department of Health and Human Services
$859.6K
LONGITUDINAL STUDY OF COGNITIVE AGING
Department of Health and Human Services
$777.4K
PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
Department of Health and Human Services
$740.4K
INTRASPINAL MICROSTIMULATION FOR RESTORING LIMB MOVEMENT
Department of Health and Human Services
$673.6K
RECOVERY OF MOTONEURON EXCITABILITY AFTER SPINAL INJURY
Department of Defense
$429.3K
EVALUATION OF A NOVEL T CELL-DERIVED PEPTIDE FOR DELIVERY OF ANTISENSE OLIGONUCLEOTIDES TO TREAT DMD CARDIOMYOPATHY
Department of Defense
$423.8K
STUDIES ON THE DYNAMIC FAILURE OF DAMAGED AND GRANULAR BRITTLE MATERIALS
Department of Health and Human Services
$378K
ISLET TRANSPLANT - COSTIMULATORY BLOCKADE WITH LEA29Y
Department of Health and Human Services
$358.9K
ULTRASENSITIVE BISPECIFIC ANTIBODY ASSAY FOR SARS VIRUS
Department of Health and Human Services
$354.2K
ROLE OF SIGLEC-10/G AS A TUMOR SUPPRESSOR IN B-CELLS
Department of Health and Human Services
$324.2K
PARKINSON DISEASE NEUROPROTECTION TRIAL: CLINICAL CENTER
Department of Health and Human Services
$323.9K
HIGH FREQUENCY WEARABLE AND TRANSPARENT ELECTROSTRICTIVE ROW-COLUMN ARRAYS FOR WHOLE BRAIN FUNCTIONAL IMAGING - PROJECT SUMMARY/ABSTRACT SECTION ENTER THE TEXT HERE THAT IS THE NEW ABSTRACT INFORMATION FOR YOUR APPLICATION. THIS SECTION MUST BE NO LONGER THAN 30 LINES OF TEXT. WE PROPOSE THE DEVELOPMENT OF A NOVEL BIAS-SWITCHABLE ROW-COLUMN 2D ULTRASOUND TRANSDUCER ARRAY TECHNOLOGY FOR 3D ULTRASOUND AND PHOTOACOUSTIC IMAGING OF WHOLE-BRAIN FUNCTIONAL ACTIVITY WITH POTENTIAL FOR A WEARABLE FORMAT FOR AWAKE AND MOVING ANIMALS. THESE CAN BE DEVELOPED INTO HIGH- FREQUENCY ARRAYS AND EVEN TRANSPARENT VARIANTS THAT SHOULD ALLOW OPTICAL AND ULTRASONIC IMAGING DOWN TO RESOLUTIONS OF 30 MICRONS, APPROACHING SINGLE-NEURON SCALES. UNLIKE PREVIOUS 2D ARRAY TECHNOLOGIES THAT REQUIRE WIRES CONNECTING TO EACH TRANSDUCER ELEMENT, OUR APPROACH REQUIRES ONLY ROW- AND COLUMN ADDRESSING, YET PERMITS READOUT FROM EVERY ELEMENT OF THE ARRAY USING NOVEL ELECTROSTRICTIVE BIAS SWITCHING APPROACHES. THE TECHNOLOGY PROMISES FIRST-OF-IT’S KIND VOLUMETRIC FUNCTIONAL BRAIN IMAGING OF BLOOD-FLOW CHANGES, BLOOD OXYGENATION CHANGES, AND EVEN NEURON ACTIVITY OVER THE WHOLE BRAINS OF AWAKE AND MOVING RODENTS. THE ARRAY OFFERS SIGNIFICANT POTENTIAL FOR NEXT-GENERATION NEUROSCIENCE EXPERIMENTS INVOLVING BOTH OPTICAL AND ACOUSTIC METHODS, INCLUDING FUTURE WORK COMBINING FUNCTIONAL ULTRASOUND AND PHOTOACOUSTIC IMAGING WITH OPTOGENETICS, OPTICAL MICROSCOPY OF GENETICALLY-ENCODED REPORTERS OF NEURON ACTIVITY, ULTRASOUND NEURO-STIMULATION, ULTRASOUND BLOOD-BRAIN BARRIER DISRUPTION FOR DRUG DELIVERY, AND MORE. THE ARRAYS HAVE CONSIDERABLE TRANSLATIONAL POTENTIAL FOR FUTURE HUMAN SUBJECT IMAGING IN NEUROSURGERIES, NEONATES, AND WITH POTENTIAL FOR IMPLANTABLE DEVICES FOR LONGITUDINAL FUNCTIONAL BRAIN IMAGING. OUR RESEARCH METHODS INCLUDE CAREFUL DESIGN AND FABRICATION OF THESE HIGH-FREQUENCY ARRAYS WITH SPECIAL ATTENTION TO TRANSPARENT VARIANTS. WE ALSO DEVELOP NOVEL IMAGING SCHEMES AND IMPLEMENT THESE SCHEMES ON PROGRAMMABLE ULTRASOUND SYSTEMS. TESTING WILL INCLUDE ARRAY CHARACTERIZATION, IMAGING PHANTOMS, IMAGING CELLS EXPRESSING NEAR-INFRARED (NIR) GENETICALLY-ENCODED REPORTERS OF NEURON CALCIUM ACTIVITY. IF SUCCESSFUL, FUTURE WORK WILL GO ON TO IMPLEMENT ANIMAL IMAGING EXPERIMENTS AIMING TO VISUALIZE FUNCTIONAL BRAIN IMAGING DUE TO WHISKER STIMULATION IN BOTH ANESTHETIZED AND AWAKE- MOVING ANIMALS.
Department of Health and Human Services
$320.4K
ALBERTA PREGNANCY OUTCOMES AND NUTRITION (APRON) - TOXICANT-DIET INTERACTIONS ON
Department of Defense
$300K
DYNAMIC FAILURE AND FRAGMENTATION OF ADVANCED CERAMICS 1: COMPRESSION AND IMPACT EXPERIMENTS
Department of Health and Human Services
$297K
WEARABLE ELECTROSTRICTIVE ROW-COLUMN ULTRASOUND ARRAYS FOR LONGITUDINAL ECHOCARDIOGRAPHY - PROJECT SUMMARY / ABSTRACT IN PATIENTS ADMITTED TO INTENSIVE CARE UNITS (ICUS) WITH SHOCK (LOW BLOOD PRESSURE) THAT RESULTS IN BOTH CLINICAL AND BIOCHEMICAL EVIDENCE OF TISSUE HYPOPERFUSION DUE TO INADEQUATE CARDIAC OUTPUT, CLINICIANS COMMONLY SEEK TO ASSESS AND MONITOR CARDIAC FUNCTION, BUT ALL AVAILABLE INVASIVE AND NON-INVASIVE METHODOLOGIES HAVE SIGNIFICANT LIMITATIONS AND/OR RISK. THE GOLD STANDARD METHOD TO ASSESS CARDIAC OUTPUT AND SHOCK STATES IS A PULMONARY ARTERIAL CATHETER (PAC) WHICH IS INSERTED THROUGH A VENOUS CANULA AND PASSES THROUGH THE RIGHT SIDE OF THE HEART INTO THE PULMONARY ARTERY. THE ADVANTAGES OF THIS MODALITY ARE THAT IT PROVIDES INFORMATION ON RIGHT AND LEFT HEART PRESSURES, AND ALLOWS FOR THE CALCULATION OF CARDIAC OUTPUT VIA THERMODILUTION TECHNIQUES. ITS DISADVANTAGES INCLUDE THE INVASIVE NATURE RESULTING THE POTENTIAL RISK OF VASCULAR INJURY. MOREOVER, CARDIAC OUTPUTS ARE INACCURATE IN COMMON CARDIAC ARRHYTHMIAS (EX ATRIAL FIBRILLATION) AND VALVULAR LESIONS (EX TRICUSPID REGURGITATION), AND ONLY PROVIDES INFORMATION ON OVERALL CARDIAC FUNCTION WITHOUT DIRECT INFORMATION ON LEFT AND RIGHT HEART FUNCTION. NON-INVASIVE CARDIAC OUTPUT MONITORS (NICOMS) USE PROPRIETARY BIO-IMPEDANCE OR ARTERIAL LINE AREA UNDER THE CURVE ALGORITHMS TO ESTIMATE CARDIAC OUTPUT. WHILE THESE ARE MINIMALLY INVASIVE, THEY HAVE NOT BEEN WELL VALIDATED IN PATIENTS IN CARDIOGENIC SHOCK AND PROVIDE NO INFORMATION ON LEFT AND RIGHT HEART FUNCTION. FINALLY, POINT OF CARE ULTRASOUND (POCUS) ALLOWS ECHOCARDIOGRAPHIC EVALUATION OF LEFT AND RIGHT HEART FUNCTION, BUT IT IS NOT WELL SUITED FOR EVALUATION OF CONTINUOUS OR TEMPORAL TRENDS IN CARDIAC FUNCTION GIVEN IT REQUIRES A CLINICIAN TO ACQUIRE IMAGES AT THE BEDSIDE. A WEARABLE ULTRASOUND PROBE THAT WOULD ENABLE HANDS-FREE LONGITUDINAL IMAGING OF PATIENTS WOULD PROVE TO BE OF CONSIDERABLE VALUE IN THE ICU ENVIRONMENT. IN THIS PROPOSAL WE INTRODUCE A RADICALLY NEW WEARABLE ULTRASOUND TECHNOLOGY, BIAS-SENSITIVE ELECTROSTRICTIVE TOP- ORTHOGONAL-TO-BOTTOM ELECTRODE (TOBE) ARRAYS. THESE TOBE ARRAYS OFFER READOUT FROM EVERY ELEMENT OF A 2D ARRAY THROUGH BIASING CONTROL AND TRANSMIT-RECEIVE CONTROL OF ONLY ROWS AND COLUMNS, RATHER THAN REQUIRE WIRING FROM EVERY ELEMENT. WITH NOVEL READOUT APPROACHES, THESE ARRAYS WILL BE DEMONSTRATED TO ACHIEVE IMAGE QUALITY COMPARABLE TO A LINEAR ARRAY, BUT WITH FULL ELECTRONIC 3D SCANNING CAPABILITIES. UNLIKE MATRIX PROBES THAT RELY ON COMPLICATED MICRO-BEAMFORMERS, OUR APPROACH IS SIMPLER, YET ALLOWS FOR ADVANCED IMAGING MODES SUCH AS ULTRAFAST IMAGING AT THOUSANDS OF FRAMES PER SECOND. WE PROPOSE THE DEVELOPMENT OF SUCH ULTRAFAST IMAGING MODES WITH WEARABLE TOBE PROBES FOR ANGLE-AGNOSTIC FLOW ESTIMATION AND LONGITUDINAL ELECTRONIC TRACKING OF RIGHT AND LEFT HEART FUNCTION. THE ANGLE-AGNOSTIC FLOW ESTIMATION AVOIDS ERRORS DUE TO UNKNOWN DOPPLER ANGLES AND MITIGATES THE NEED FOR MANUAL PROBE POSITIONING. IN THIS PROPOSAL, WE AIM TO FURTHER DEVELOP THE TRANSDUCER TECHNOLOGY, INTERFACING ELECTRONICS, AND IMAGING METHODS TO ENABLE ANGLE-AGNOSTIC FLOW IMAGING IN PHANTOMS, THEN WITH FIRST-IN-HUMAN IMAGING. WE AIM TO ESTABLISH FEASIBILITY DATA FOR FUTURE RESEARCH INTO ADVANCED LONGITUDINAL MONITORING OF CARDIAC OUTPUT, EJECTION FRACTIONS, PULMONARY ARTERY PRESSURE, ETC.
Department of Health and Human Services
$262.2K
INTERACTION OF CARDIOTONIC DRUGS WITH CARDIAC TROPONIN
Department of Transportation
$240K
ACHIEVING MAXIMUM CRACK REMEDIATION EFFECT FROM OPTIMIZED HYDROTESTING
Department of Defense
$216K
MECHANISM OF BLAST AND IMPACT ENERGY TRANSFER INTO THE HEAD OF THE HELMETED WARFIGHTER
Department of Defense
$196.8K
MULTIPLE SCLEROSIS RESEARCH PROGRAM
Department of Defense
$149.6K
GRANT
Department of Health and Human Services
$132.7K
INTERNAL TISSUES AFFECTED BY SPINAL MANIPULATION
Department of Defense
$120.5K
BIOFLUID-BASED DETECTION OF THE MIGRATION SWITCH IN PROSTATE CANCER TO PREDICT METASTATIC DISEASE
Department of Defense
$99.7K
CHARACTERIZATION OF A NOVEL MECHANISM OF MERLIN-ASSOCIATED POST-TRANSCRIPTIONAL GENE REGULATION
Department of the Interior
$98.8K
BOREAL AVIAN MODELLING PROJECT PHASE IV
Department of Defense
$86.5K
MECHANISMS OF POST-TRANSCRIPTIONAL REGULATION BY THE TUMOR SUPPRESSOR MERLIN
Department of Defense
$82.4K
TOWARDS A BIOMECHANICALLY VALID SIMULANT MODEL OF THE HUMAN CALVARIUM
Department of the Interior
$78.6K
RECIPIENT NAME: THE GOVERNORS OF THE UNIVERSITY OF ALBERTACOOPERATIVE AGREEMENT NUMBER: G25AC00208PROJECT TITLE: THE ROLE OF DNA METHYLATION IN MORPHOLOGICAL DEFORMITIES IN ARTIFICIALLY REARED CISCOOVERALL PROJECT PERIOD: 04 16 2025 THROUGH 04 15 2030OVERALL BUDGET PERIOD: 04 16 2025 THROUGH 04 15 2026AWARD PURPOSE: THE PURPOSE OF THIS AWARD IS TO INVESTIGATE THE EFFECTS OF DIFFERENT CAPTIVE REARING PROTOCOLS DURING SUPPLEMENTATION AND CONSERVATION EFFORTS ON CISCO (COREGONUS ARTEDI). WE WILL ASSESS HOW DIFFERENT TEMPERATURE REARING PROTOCOLS AFFECT DNA METHYLATION, A MOLECULAR MECHANISM THAT AFFECTS GENE EXPRESSION AND IS OFTEN IMPLICATED AS A MECHANISM FOR THE REDUCED FITNESS AND SURVIVAL OF CAPTIVE-REARED FISH. WE WILL DETERMINE IF SPECIFIC REARING PROTOCOLS MINIMIZE THE UNINTENDED MOLECULAR EFFECTS OF CAPTIVE REARING, LEADING TO THE PRODUCTION OF CAPTIVE CISCO THAT RESEMBLE WILD CISCO AND SURVIVE BETTER IN THE WILD.ACTIVITIES TO BE PERFORMED:CISCO WILL BE SAMPLED FROM DIFFERENT CAPTIVE REARING FACILITIES FOCUSED ON SUPPLEMENTATION OF WILD POPULATIONS, INCLUDING THE JORDAN RIVER HATCHERY AND USGS HAMMOND BAY BIOLOGICAL STATION. SPECIFICALLY, WE WILL SAMPLE CAPTIVE-REARED CISCO REARED IN DIFFERENT THERMAL ENVIRONMENTS, INCLUDING (1) AN OUTDOOR ARTIFICIAL STREAM, (2) A HATCHERY ENVIRONMENT UNDER STANDARD REARING TEMPERATURE FOR FISH PRODUCTION, AND (3) A HATCHERY ENVIRONMENT WITH A NATURAL THERMAL REGIME. WILD CISCO WILL BE SAMPLED FROM SEVERAL NEARBY REGIONS IN LAKE HURON THROUGH COLLABORATION WITH US FISH AND WILDLIFE, THE BAY MILLS INDIAN COMMUNITY, AND THE ONTARIO MINISTRY OF NATURAL RESOURCES. DNA WILL BE EXTRACTED FROM 80 SAMPLES (IDEALLY 40 WILD AND 40 CAPTIVE-REARED CISCO) FOR WHOLE-GENOME ENZYMATIC METHYL-SEQ TO CHARACTERIZE WHOLE-GENOME DIFFERENCES IN METHYLATION AMONG (1) CAPTIVE AND WILD CISCO, AND (2) CISCO FROM DIFFERENT CAPTIVE REARING PROTOCOLS. WE WILL ASSESS HOW DIFFERENCES IN CAPTIVE REARING PROTOCOLS AFFECT DNA METHYLATION, AND WHICH GENES ARE AFFECTED BY DIFFERENT PROTOCOLS. WE WILL ALSO DETERMINE WHETHER SPECIFIC REARING PROTOCOLS LEAD TO CISCO DNA METHYLATION PATTERNS THAT MORE CLOSELY RESEMBLE WILD FISH, WHICH COULD IMPROVE CISCO SURVIVAL AFTER RELEASE INTO THE WILD. WE WILL DETERMINE WHETHER THERE ARE SHARED METHYLATION DIFFERENCES AMONG ALL CAPTIVE REARED CISCO, WHICH COULD SUPPORT THE FUTURE DEVELOPMENT OF EPIGENETIC BIOMARKERS TO DIFFERENTIATE CAPTIVE-REARED AND WILD CISCO BASED ON FIN CLIPS.DELIVERABLES AND EXPECTED OUTCOMES:WE WILL GENERATE WHOLE GENOME DNA METHYLATION DATA FOR CAPTIVE AND WILD CISCO.WE WILL DETERMINE WHETHER THE USE OF DIFFERENT CAPTIVE REARING PROTOCOLS CAN REDUCE THE UNINTENDED EFFECTS OF CAPTIVE REARING ON CISCO DNA METHYLATION, WHICH LIKELY SERVES AS THE MECHANISM FOR THE REDUCED FITNESS OF CAPTIVE-REARED FISH WHEN RELEASED INTO THE WILD.WE WILL TEST FOR CONSISTENT EFFECTS OF CAPTIVE REARING ACROSS DIFFERENT CAPTIVE REARING PROTOCOLS, WHICH WILL SERVE AS A PILOT STUDY TOWARDS THE DEVELOPMENT OF EPIGENETIC BIOMARKERS TO DIFFERENTIATE CAPTIVE-REARED AND WILD FISH.WE EXPECT THAT THESE RESULTS WILL PROVIDE FURTHER INSIGHT INTO THE EFFECTS OF DIFFERENT REARING ENVIRONMENTS ON CAPTIVE-REARED CISCO, WITH THE ULTIMATE GOAL OF PRODUCING MORE NATURAL FISH READY TO FACE NATURE.INTENDED BENEFICIARY(IES): THIS WORK WILL BENEFIT USGS RESEARCH GOALS AND OBJECTIVES IN COREGONINE RESTORATION, INCLUDING UNDERSTANDING THE EFFECTS OF DIFFERENT REARING ENVIRONMENTS ON CISCO, AND THE POTENTIAL FOR EPIGENETIC BIOMARKERS TO NONLETHALLY IDENTIFY ARTIFICIALLY REARED CISCO. THE RESULTS WILL ALSO BE SHARED WITH INTERESTED STAKEHOLDERS, INCLUDING THE JORDAN RIVER HATCHERY AND OTHERS INVOLVED IN COREGONINE RESTORATION IN THE GREAT LAKES.
Department of Defense
$41.9K
INVESTIGATING MUC1/ICAM-1 BINDING INDUCED SIGNALING IN BREAST CANCER METASTASIS
Department of Defense
$40.3K
SPLICING FACTOR KINASE SRPK1 REGULATES METASTATIC DISSEMINATION OF HUMAN PROSTATE CANCER
Department of State
$13.5K
AWARD TO BE USED TO FUND SPEAKERS' ACCOMODATIONS EQUIPMENT AND FACILITIES RENTAL. THE INSTITUTE IS THE ONLY U.S. ORIENTED RESEARCH INSTITUE IN THE P
Department of Agriculture
$7,380
INTERNATIONAL CONFERENCE ON PIG REPRODUCTION
Source: Federal Audit Clearinghouse (fac.gov)
No federal single audit records found for this organization.
Single audits are required for entities expending $750,000+ in federal awards annually.
Source: IRS e-Filed Form 990
No officer or director compensation data available for this organization.
This data is sourced from IRS Form 990, Part VII. It may not be available if the organization files Form 990-N (e-Postcard) or has not yet been enriched.
Source: IRS Publication 78, Auto-Revocation List & e-Postcard Data
Tax-deductible contributions: Yes
Deductibility code: FORGN
Sources: IRS e-Filed Form 990 (XML) & ProPublica Nonprofit Explorer
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| Year | Revenue | Contributions | Expenses | Assets | Net Assets |
|---|---|---|---|---|---|
| 2024 | $1.5B | $823.9M | $1.4B | $4.7B | $2B |
| 2023 | $1.4B | $833.1M | $1.4B | $4.6B | $1.9B |
| 2022 | $1.5B | $857.1M | $1.4B | $4.9B | $2.1B |
| 2021 | $1.3B | $850.4M | $1.3B | $4.7B |
Sources: ProPublica Nonprofit Explorer & IRS e-File Index
| Tax Year | Form Type | Source | Documents |
|---|---|---|---|
| 2024 | 990 | DataIRS e-File | PDF not yet published by IRSView Filing → |
| 2023 | 990 | DataIRS e-File | |
| 2022 | 990 | Data |
Financial data: IRS Form 990 via ProPublica Nonprofit Explorer (Tax Year 2024)
Federal grants: USAspending.gov (live)
Organization info: IRS Business Master File · ProPublica Nonprofit Explorer
Tax-deductibility: IRS Publication 78
| $2B |
| 2020 | $1.4M | $926.2K | $1.4M | $3.7M | $1.4M |
| 2019 | $1.5M | $1M | $1.4M | $4.1M | $1.7M |
| 2018 | $1.5M | $1M | $1.5M | $4.1M | $1.6M |
| 2017 | $1.4M | $971.2K | $1.4M | $3.8M | $1.4M |
| 2016 | $1.4M | $963.9K | $1.4M | $3.8M | $1.3M |
| 2015 | $1.6M | $1.1M | $1.5M | $4.1M | $1.4M |
| 2014 | $1.7M | $1.1M | $1.7M | $4.4M | $1.3M |
| 2013 | $1.7M | $1.2M | $1.7M | $4.6M | $1.3M |
| 2012 | $1.6M | $1.1M | $1.7M | $4.7M | $1.4M |
| 2021 | 990 | Data | PDF not yet published by IRS |
| 2020 | 990 | Data |
| 2019 | 990 | Data |
| 2018 | 990 | Data |
| 2017 | 990 | Data |
| 2016 | 990 | Data |
| 2015 | 990 | Data |
| 2014 | 990 | Data |
| 2013 | 990 | Data |
| 2012 | 990 | Data |
| 2011 | 990 | — |
| 2010 | 990 | — |
| 2009 | 990 | — |
| 2008 | 990 | — |
| 2007 | 990 | — |
| 2006 | 990 | — |
| 2005 | 990 | — |
| 2004 | 990 | — |
| 2003 | 990 | — |
| 2002 | 990 | — |