University Of Manitoba

INCREASING ACCESS TO QUALITY COMPREHENSTIVE HIV PREVENTION SERVICES FOR MOST-AT-R

PURPOSE OF THIS MODIFICATION IS TO PROVIDE INCREMENTAL FUNDING TO THE AGREEMENT. CUMILATIVE OBLIGATED AMOUNT WITH THIS ACTION IS $8 400 000.00.

HIV TREATMENT FOR RESEARCH SUBJECTS OR BY RESEARCHERS IN KENYA

A NOVEL HIV-1 VACCINE TARGETING THE 12 PROTEASE CLEAVAGE SITES

THE MULTI-OMIC MILK (MUMI) STUDY: LEVERAGING THE IMIC PLATFORM AND THE CHILD COHORT TO STUDY HUMAN MILK AS A BIOLOGICAL SYSTEM AND UNDERSTAND ITS COMPOSITION, DETERMINANTS AND IMPACTS ON CHILD HEALTH - PROJECT SUMMARY SIGNIFICANCE: HUMAN MILK (HM) HAS EVOLVED OVER MILLIONS OF YEARS TO NOURISH AND PROTECT HUMAN INFANTS - YET WE KNOW SURPRISINGLY LITTLE ABOUT ITS COMPOSITION, VARIATION, AND FUNCTION. TRADITIONALLY, HM RESEARCH HAS FOCUSED ON INDIVIDUAL HM COMPONENTS, YET HM IS A COMPLEX BIOLOGICAL SYSTEM COMPRISING THOUSANDS OF COMPONENTS THAT INTERACT AND FUNCTION IN COMBINATION. MOREOVER, WHILE HM COMPOSITION IS KNOWN TO BE AFFECTED BY MATERNAL, INFANT, AND ENVIRONMENTAL FACTORS, THESE ARE POORLY UNDERSTOOD AND RARELY EXAMINED SIMULTANEOUSLY. TO ADDRESS THESE GAPS, OUR TEAM IS CHAMPIONING A MULTI-OMICS SYSTEMS BIOLOGY APPROACH TO STUDY HM AS A “SYSTEM WITHIN A SYSTEM”, REFLECTING THAT MILK ITSELF IS A SYSTEM EMBEDDED WITHIN THE “MOTHER-MILK-INFANT” TRIAD. APPROACH: THIS GRANT WILL LEVERAGE AND UNITE TWO ESTABLISHED HM RESEARCH PLATFORMS TO INVESTIGATE HM AND ITS DETERMINANTS AND HEALTH IMPACTS AMONG 1600 MOTHER-INFANT DYADS USING A NOVEL MULTI-OMIC APPROACH. THE INTERNATIONAL MILK COMPOSITION (IMIC) CONSORTIUM IS A NETWORK OF HM RESEARCHERS AND DATA SCIENTISTS WITH AN ESTABLISHED INFRASTRUCTURE FOR MULTI-OMIC HM RESEARCH. CHILD IS AN ONGOING NATIONAL PREGNANCY COHORT OF 3600 CHILDREN BORN IN 2009-12. OUR TEAM HAS ALREADY ANALYZED 1600 CHILD HM SAMPLES FOR 19 OLIGOSACCHARIDES, 28 FATTY ACIDS, AND HUNDREDS OF BACTERIA. WE WILL NOW ENHANCE THE RICH CHILD DATASET WITH NEW MULTI-OMIC HM ANALYSES (20 NUTRIENTS, 15 NON-NUTRITIVE BIOACTIVE PROTEINS AND THOUSANDS OF METABOLITES) AND APPLY UNSUPERVISED MACHINE LEARNING METHODS TO IDENTIFY DISCRETE ‘LACTOTYPES’ (AIM 1). NEXT, WE WILL LEVERAGE THE RICH CHILD DATA TO IDENTIFY MATERNAL, INFANT AND ENVIRONMENTAL FACTORS ASSOCIATED WITH LACTOTYPE MEMBERSHIP AND/OR INDIVIDUAL HM COMPONENTS (AIM 2). FINALLY, WE WILL USE MACHINE LEARNING METHODS TO UNDERSTAND HOW HM COMPOSITION INFLUENCES MICROBIOME DEVELOPMENT, GROWTH, WHEEZING AND ALLERGIES DURING INFANCY AND CHILDHOOD (AIM 3). INNOVATION: INTEGRATING THE CHILD AND IMIC PLATFORMS WILL FACILITATE UNPRECEDENTED RESEARCH ON HM AS A SYSTEM-WITHIN-A-SYSTEM AND GENERATE THE WORLD’S LARGEST AND MOST DEEPLY-PHENOTYPED MOTHER-MILK-INFANT DATASET (N=1600 TRIADS WITH MULTI-OMIC MILK PROFILES AND RICH LONGITUDINAL MATERNAL AND INFANT METADATA). THIS PROJECT WILL UNITE EXPERT HM SCIENTISTS, RENOWNED PEDIATRIC RESEARCHERS AND DATA SCIENTISTS AT THE FOREFRONT OF MULTI-OMIC METHODS DEVELOPMENT, PLACING THE INTERDISCIPLINARY MUMI TEAM IN AN UNRIVALED POSITION TO MAKE NOVEL DISCOVERIES IN THIS SPACE AND REVOLUTIONIZE THE WAY HM IS STUDIED AND UNDERSTOOD.

POLYGENICITY OF BRAIN AND PHYSICAL RESERVE IN MULTIPLE SCLEROSIS

PSYCHIATRIC DISORDER GENOMIC RISK SCORES AS A CORRELATE OF DISEASE ACTIVITY AND PROGRESSION IN MULTIPLE SCLEROSIS. NEW AWARD.

BIOMARKER GUIDED CNI SUBSTITUTION IN KIDNEY TRANSPLANTATION

EVALUATING THE IMPACT OF GHOST CRABS ON SEA TURTLE HATCHLINGS

NEAR INFRARED BASED CEREBROVASCULAR REACTIVITY AS A MEANS OF MONITORING CEREBRAL AUTOREGULATION AND PREDICTING OUTCOME IN MODERATE/SEVERE TRAUMATIC BRAIN INJURY: A PILOT STUDY

EXPOSURE OF MARINE BIRDS TO ACUTE AND CHRONIC OIL POLLUTION HAS WIDESPREAD IMPACTS, INCLUDING DIRECT MORTALITY ASWELL AS A VARIETY OF SUB-LETHAL EFFECTS SUCH AS REDUCED BREEDING SUCCESS AND INCREASED PHYSIOLOGICAL STRESS.THESE OIL-RELATED IMPACTS ARE DUE TO THE TOXICITY OF VARIOUS SUBSTANCES WITHIN OIL AND GAS, NOTABLY POLYCYCLICAROMATIC COMPOUNDS, PACS. SEA DUCKS, AS DIVING BIRDS AND BENTHIC FORAGERS, MAY HAVE INCREASED EXPOSURE TO OIL RELATED POLLUTANTS THROUGH CONTACT ON THE WATER SURFACE, IN THE WATER COLUMN, AND FROM ACCUMULATED TOXINS INBENTHIC PREY WHICH THEY FEED ON. DECLINING POPULATIONS OF COMMON EIDERS IN ATLANTIC CANADA ARE EXPOSED TO A WIDERANGE OF ANTHROPOGENIC ACTIVITIES WITH ASSOCIATED OIL-RELATED POLLUTION, BUT BASELINE LEVELS OF PACS ARE UNKNOWN.QUANTIFYING CONTAMINANT LOADS THROUGHOUT THEIR BREEDING RANGE IS IMPORTANT FOR UNDERSTANDING EXPOSURE AND IMPACTSTO THE SPECIES, BUT ALSO INTEGRAL UNDERSTANDING TO FOOD SAFETY FOR INUIT AND FIRST NATIONS IN THE REGION WHOCONSUME EIDERS AND THEIR EGGS. INITIAL STUDIES OF PACS IN EIDER EGGS FROM NORTHERN LABRADOR HAVE LED TORECOMMENDATIONS ON LIMITATIONS TO MONTHLY CONSUMPTION. THIS STUDY WILL QUANTIFY PAC CONCENTRATIONS IN EGGS OFCOMMON EIDERS ACROSS 18 BREEDING SITES IN EASTERN CANADA, INCLUDING LABRADOR, NEWFOUNDLAND, THE GULF OF ST.LAWRENCE, THE SCOTIAN SHELF, AND THE BAY OF FUNDY (GULF OF MAINE). THIS WILL ALLOW FOR COMPARISONS WITH PACCONCENTRATIONS IN THESE AND OTHER SPECIES ACROSS THEIR RANGE, AND REGIONAL POLLUTION RISKS (I.E., VESSEL TRAFFICPATTERNS AND POLLUTION INCIDENT REPORTS). THESE RESULTS WILL FORM BASELINES AGAINST WHICH MANAGERS CAN 1)QUANTIFY THE IMPACTS OF CURRENT ANTHROPOGENIC ACTIVITIES, FUTURE SPILLS, AND CHANGES IN VESSEL TRAFFIC PATTERNS,AND 2) ASSESS LONG-TERM TRENDS AND RECOVERY FROM OIL-RELATED POLLUTION.

MIGRATION ECOLOGY AND CARRY-OVER EFFECTS ON PRODUCTIVITY IN CACKLING GEESE (BRANTA HUTCHINSII) AND SUB-ARCTIC BREEDING CANADA GEESE (BRANTA CANADENSIS)

PS10-10133: INCREAS. ACC. TO QUAL. COMP. HIV PREVENTION SERVICES FOR MOST-AT-R

DEOBLIGATION