Ceiba Inc

CEIBA STRATEGIES WILL COLLABORATE WITH LOCAL COMMUNITIES ON THE WEST END OF ST. CROIX IN A RIDGE-TO-REEF WATERSHED EFFORT TO RESTORE COASTAL HABITAT AND CORAL REEFS. THEY WILL OUTPLANT CORALS ON REEFS IN BUTLER BAY AND IMPLEMENT WATERSHED MANAGEMENT PRACTICES TO PROTECT CORAL FROM LAND-BASED SOURCES OF POLLUTION. THEY WILL ALSO HELP BUILD COMMUNITY CAPACITY FOR RESTORATION THROUGH PAID INTERNSHIP AND MENTORSHIP OPPORTUNITIES, EDUCATIONAL PROGRAMS FOR LOCAL SCHOOLS, AND AN ADVISORY COUNCIL OF COMMUNITY LEADERS.

FINANCIAL ASSISTANCE AWARD

DEVELOPING BLOOD-BASED EXERCISE MIMETIC AS A TREATMENT FOR ALZHEIMER'S DISEASE AND RELATED DEMENTIAS - PROJECT SUMMARY DESPITE THE GROWING NUMBER OF ADULTS THAT ARE LIVING WITH ALZHEIMER’S DISEASE (AD) WORLDWIDE, THERE STILL LACKS DISEASE MODIFYING TREATMENTS. PHYSICAL ACTIVITY AND EXERCISE MITIGATE AD RISK AND BOOSTS COGNITIVE FUNCTIONS IN PATIENTS, YET OVER A QUARTER OF THE ELDERLY DO NOT MEET THESE ACTIVITY GUIDELINES, OFTEN DUE TO PHYSICAL LIMITATIONS AND RESOURCE CONSTRAINTS. CURRENT THERAPEUTIC APPROACHES FOCUSED ON AD ARE RESTRICTED TO TARGETING NEUROPATHOLOGY WITHIN THE CENTRAL NERVOUS SYSTEM. THUS, THERE IS AN IMPERATIVE NEED TO DEVELOP ALTERNATIVE THERAPIES THAT CONFER BENEFITS OF EXERCISE TO AD PATIENTS, CIRCUMVENTING THEIR PHYSICAL LIMITATIONS. PRIOR WORK BY OUR RESEARCH TEAM IDENTIFIED GLYCOSYLPHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE D1 (GPLD1) AN EXERCISE-INDUCED CIRCULATING FACTOR IN BLOOD PLASMA THAT MEDIATES THE NEUROGENIC AND COGNITIVE BENEFITS OF EXERCISE IN AGED MICE AND SHOWS NEUROBEHAVIORAL RELEVANCE IN ELDERLY HUMAN ADULTS. SYSTEMICALLY INCREASING GPLD1 LEVELS IN BLOOD MIMICKED THE BENEFICIAL EFFECTS OF EXERCISE ON COGNITIVE FUNCTION AND AD-RELATED NEUROPATHOLOGY IN AGED MICE AND MOUSE MODELS OF AD PATHOLOGY. THE PURPOSE OF THIS STUDY IS TO TRANSLATE THE SCIENTIFIC DISCOVERIES IDENTIFYING PERIPHERAL TARGETS IN BLOOD – GPLD1 IN PARTICULAR – AS NOVEL POTENTIAL THERAPEUTIC BLOOD-BASED EXERCISE MIMETICS TO TREAT AD- RELATED DEMENTIAS. WE WILL ACHIEVE THIS WITH THREE SPECIFIC AIMS: 1: IDENTIFY THREE LEAD RECOMBINANT HUMAN GPLD1 MOLECULES. 2: ESTABLISH OPTIMAL EXPOSURE THROUGH EXTENSIVE IN VIVO PK PROFILING IN AGED WILD TYPE MICE OF THE THREE LEAD RECOMBINANT HUMAN GPLD1 MOLECULES. 3: TEST ONE PRIMARY AND ONE ALTERNATE LEAD RECOMBINANT HUMAN GPLD1 MOLECULE FOR DISEASE MODIFICATION IN THE 5XFAD MOUSE MODEL OF AD PATHOLOGY. SUCCESSFUL COMPLETION OF THESE AIMS IS THE CRITICAL FIRST STEP FOR THE IDENTIFICATION AND COMMERCIALIZATION OF POTENTIAL THERAPEUTIC BLOOD- BASED EXERCISE MIMETICS TO TREAT AD-RELATED DEMENTIAS.

DEVELOPMENT OF PLATELET-DERIVED EXERCISE MIMETICS AS A TREATMENT FOR ALZHEIMER'S DISEASE AND ALZHIMER'S DISEASE RELATED DEMENTIAS - PROJECT SUMMARY DESPITE THE GROWING NUMBER OF ADULTS THAT ARE LIVING WITH ALZHEIMER’S DISEASE (AD) WORLDWIDE, THERE STILL LACKS DISEASE MODIFYING TREATMENTS. PHYSICAL ACTIVITY AND EXERCISE MITIGATE AD RISK AND BOOSTS COGNITIVE FUNCTIONS IN PATIENTS, YET OVER A QUARTER OF THE ELDERLY DO NOT MEET THESE ACTIVITY GUIDELINES, OFTEN DUE TO PHYSICAL LIMITATIONS AND RESOURCE CONSTRAINTS. CURRENT THERAPEUTIC APPROACHES FOCUSED ON AD ARE RESTRICTED TO TARGETING NEUROPATHOLOGY WITHIN THE CENTRAL NERVOUS SYSTEM. THUS, THERE IS AN IMPERATIVE NEED TO DEVELOP ALTERNATIVE THERAPIES THAT CONFER BENEFITS OF EXERCISE TO AD PATIENTS, CIRCUMVENTING THEIR PHYSICAL LIMITATIONS. PRIOR WORK BY OUR RESEARCH TEAM IDENTIFIED AN EXERCISE-INDUCED PLATELET-DERIVED FACTORS IN BLOOD PLASMA THAT MEDIATES THE NEUROGENIC AND COGNITIVE BENEFITS OF EXERCISE IN AGED MICE. SYSTEMICALLY INCREASING THIS BLOOD BASED EXERCISE MIMETIC CONFERRED BENEFICIAL EFFECTS OF EXERCISE ON COGNITIVE FUNCTION AND AD-RELATED NEUROPATHOLOGY IN AGED MICE AND MOUSE MODELS OF AD PATHOLOGY. THE PURPOSE OF THIS STUDY IS TO TRANSLATE THE SCIENTIFIC DISCOVERIES IDENTIFYING THIS PLATELET-DERIVED EXERCISE MIMETIC AS NOVEL POTENTIAL THERAPEUTIC TO TREAT AD AND RELATED DEMENTIAS. THIS IS A FAST- TRACK PHASE I TO PHASE II PROPOSAL THAT IN PHASE I AIMS TO (1) GENERATE VARIOUS CLONES OF THE PLATELET-DERIVED EXERCISE MIMETIC WITH DECREASED SAFETY RISKS AND RETAINED FUNCTION, (2) OPTIMIZATION OF THE EXPRESSION AND PURIFICATION OF THIS PLATELET-DERIVED EXERCISE MIMETIC AND (3) DEMONSTRATE THAT THE PROTEIN ENGINEERED PLATELET-DERIVED EXERCISE MIMETIC CAN CONFER IMPROVED COGNITIVE FUNCTION IN AGED MICE AND A MOUSE MODEL OF AD PATHOLOGY. IN PHASE II, WE AIM TO (4) PERFORM EXPLORATORY TOXICITY STUDIES TO BETTER UNDERSTAND THE THERAPEUTIC WINDOW AND (5) BEGIN CMC PROCESS DEVELOPMENT IN SUPPORT OF IND-ENABLING STUDIES.

THE PURPOSE OF THE COPS HIRING PROGRAM (CHP) PROGRAM IS TO ADVANCE THE PRACTICE OF COMMUNITY POLICING THROUGH THE HIRE OR REHIRE OF ADDITIONAL CAREER LAW ENFORCEMENT OFFICERS. FUNDING UNDER THIS AWARD PROGRAM WILL BE UTILIZED BY LOCAL LAW ENFORCEMENT AGENCIES TO HIRE AND REHIRE CAREER LAW ENFORCEMENT OFFICERS NECESSARY TO INCREASE THE JURISDICTIONS COMMUNITY POLICING CAPACITY TO PREVENT AND DISRUPT CRIME AND VIOLENCE.

ARP ECONOMIC DEVELOPMENT GRANT FOR RURAL HEALTH CARE FACILITIES

RH&ED-INNOV ACTIVITY

RH&ED-INNOV ACTIVITY

SUPPORTING PROTECTION AND RESTORATION OF COASTAL TROPICAL FOREST IN ECUADOR'S NEW CONSERVATION AND SUSTAINABLE USE AREA (ACUS)

RURAL BUSINESS ENTERPRISE GRANTS

TECHNICAL ASSISTANCE AWARD

EDUCATION AND OUTREACH INITIATIVES

HOUSING COUNSELING ASSISTANCE PROGRAM

HSNG COUNSEL ASSIST GRANTS

SOUTH AMERICA REGIONAL PROGRAM

COMPREHENSIVE HSG

RURAL HOUSING PRESERVATION GRANTS

RURAL HOUSING PRESERVATION GRANTS

HSNG COUNSEL ASSIST GRANTS

RURAL HOUSING PRESERVATION GRANTS

RURAL HOUSING PRESERVATION GRANTS

SEC. 6022 RMAP-RURAL DEVELOP GRANTS (MAN)

HOUSING COUNSELING ASSISTANCE PROGRAM

ORGANIZE TWO CULTURAL AND BILINGUAL CAMPS; 1 DAY CAMP FOR 75 HIGH SCHOOL STUDENTS AND A 3-DAY CAMP FOR ELEMENTARY STUDENTS.

HOUSING COUNSELING

THIS GRANT SUPPORTS THE COSTS INCURRED TO IMPLEMENT MEASURES TO RESPOND TO THE NOVEL CORONAVIRUS 2019 (COVID-19), WHICH MAY INCLUDE WORKPLACE SAFETY, MARKET PIVOTS, RETROFITTING FACILITIES, TRANSPORTATION, WORKER HOUSING, AND MEDICAL EXPENSES. IT PROVIDES NEEDED RELIEF TO THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS FOR THEIR COSTS INCURRED BETWEEN JANUARY 27, 2020, THE DATE UPON WHICH THE PUBLIC HEALTH EMERGENCY WAS DECLARED BY THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICE (HHS) UNDER SECTION 319 OF THE PUBLIC HEALTH SERVICE ACT, AND DECEMBER 31, 2021. BENEFICIARIES INCLUDE THE EMPLOYEES OF THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS.

HOUSING COUNSELING ASSISTANCE PROGRAM

TO ORGANIZE TWO BILINGUAL CAMPS; A ONE-DAY CAMP FOR APPROXIMATELY 90 ELEMENTARY STUDENTS, A ONE-DAY CAMP FOR APROX. 90 HIGH SCHOOL STUDENTS

TO ORGANIZE A BILINGUAL CAMP TO CELEBRATE THE 50TH ANNIVERSARY OF THE MOON LANDING AND BRING A US SPEAKER TO PARTICIPATE

SEC 9007 REAP-RENEW ENERGY SYSTEMS GRANTS, $20,000 OR LESS (MAN)