The Cleveland Clinic Foundation

IFNS AND CYTOKINES: SIGNALING AND ACTION

OXIDATION IN INFLAMMATION AND CARDIOVASCULAR DISEASE

VASCULAR CELL FUNCTION AND ATHEROSCLEROSIS

STRUCTURE AND FUNCTION OF BETA3 INTEGRINS ON BLOOD CELLS

PATHOBIOLOGY OF ASTHMA

IBUDILAST PHASE II TRIAL IN PROGRESSIVE MS

PROGNOSIS AND PREDICTORS OF ACL RECONSTRUCTION: A MULTICENTER COHORT STUDY

FUNCTIONAL GENOMICS OF ATRIAL FIBRILLATION IN HUMAN ATRIA

DATA COORDINATING CENTER FOR PILOT STUDIES OF CANDIDATE THERAPIES FOR CKD

CORNEAL EPITHELIAL GROWTH FACTORS AND RECEPTORS

CLINICAL STUDY OF VASCULAR PLAQUE DETERMINATION FOR STROKE RISK ASSESSMENT

REGULATION OF HOST INNATE IMMUNITY AGAINST VIRAL INFECTION

CELLULAR DETERMINANTS OF APOPTOSIS IN VIRUS-INFECTED CELLS

NOVEL REGULATION OF BETA-ADRENERGIC RECEPTOR FUNCTION BY PHOSPHOINOSITIDE 3-KINAS

ROLE OF ADIPOSE IN ETHANOL-INDUCED TISSUE INJURY

PATHOPHYSIOLOGICAL ACTIVITIES OF OXIDIZED PHOSPHOLIPIDS

REFERENCE MODELS FOR MULTI-LAYER TISSUE STRUCTURES

NITRIC OXIDE IN PULMONARY HYPERTENSION

TROOP READINESS EVALUATION WITH AN AUGMENTED REALITY RETURN-TO-DUTY (READY) SYSTEM: AN OBJECTIVE METHOD OF EVALUATING SERVICE MEMBER PERFORMANCE FOLLOWING MTBI

PRIMARY IMMUNOPREVENTION OF TRIPLE-NEGATIVE BREAST CANCER

MOLECULAR ELUCIDATION OF INTEGRIN SIGNALING

NEVADA EXPLORATORY ALZHEIMER'S DISEASE RESEARCH CENTER (NVEADRC)

IMPROVING SPINAL CORD INJURY REHABILITATION INTERVENTIONS BY RETRAINING THE BRAIN

A GUT-RESTRICTED SMALL MOLECULE THERAPEUTIC FOR A NOVEL TARGET TO TREAT INFLAMMATORY BOWEL DISEASE

HDL STRUCTURE, FUNCTION AND DYSFUNCTION

DIET, GUT MICROBIOTA, AND HEART FAILURE

MECHANISMS OF METABOLIC DYSREGULATION IN PULMONARY HYPERTENSION

CONVERGENCE OF MICRORNAS AND P53 SIGNALING IN MULTIPLE MYELOMA: ENVIRONMENTAL CO

ELUCIDATING AND TARGETING THE MOLECULAR FOUNDATIONS OF IDH MUTANT GLIOMA

PRIMARY IMMUNOPREVENTION OF TRIPLE-NEGATIVE BREAST CANCER

DIETARY CHOLINE, GUT MICROBIOTA, AND SUSCEPTIBILITY FOR CHRONIC KIDNEY DISEASE

THE PURPOSE OF THE PROJECT IS TO PREVENT THE LEADING CAUSE OF POSTOPERATIVE MORTALITY AFTER HEART SURGERY LOW CARDIAC OUTPUT SYNDROME LCOS BY PROVIDING AT HOME ICU LEVEL MONITORING TO CHILDREN AND ADULTS WITH CONGENITAL HEART DISEASE (CHD). THIS WILL BE ACHIEVED THROUGH THE CREATION OF A BATTERY OPERATED FLEXIBLE ULTRATHIN QUAD MODAL WIRELESS DEVICE ETATTOO FOR DAILY ABSOLUTE CARDIAC OUTPUT (CO) MONITORING. THE CURRENT STATE OF THE ART MONITORING DEVICES RELY ON DOWNSTREAM METRICS (E.G. LACTIC ACIDOSIS) ARE INVASIVE REQUIRING PULMONARY ARTERIAL CATHETERIZATION OR ARE UNFIT FOR CHILDREN. ADDITIONAL STATE OF THE ART TOOLS FOR CARDIAC OUTPUT MONITORING ARE COSTLY TO OPERATE AND ARE LIMITED BY SINGLE TIME POINT MEASUREMENTS (E.G. MAGNETIC RESONANCE IMAGING MRI).ONE IN EVERY FOUR PATIENTS WITH CONGENITAL HEART DISEASE WILL REQUIRE SURGERY AT SOME POINT. LCOS IS THE LEADING CAUSE OF POSTOPERATIVE MORTALITY IN THOSE PATIENTS. THE PROPOSED PROGRAM IS CONSIDERED A CRITICAL TECHNOLOGY EFFORT BECAUSE IT AIMS TO NONINVASIVELY ESTIMATE CARDIAC OUTPUT IN CONGENITAL HEART DISEASE PATIENTS OF ALL AGES AND TO HELP PREVENT LCOS. IN ADDITION THE TECHNOLOGY CAN BE USED AT HOME AND IT CAN BE APPLIED TO OTHER HEART SENSING APPLICATIONS. CURRENT TECHNOLOGY AND APPROACHES TO NONINVASIVE CONTINUOUS CARDIAC OUTPUT MONITORING (NICCOM) ARE NOT IDEAL AND CAN PRESENT A HIGHER RISK PROFILE. CURRENTLY ECG PATCHES ARE USED TO MONITOR CHD PATIENTS INTERMITTENTLY EVERY YEAR AND THEY DO NOT MEASURE ALL RELEVANT INFORMATION. IMPLANTABLE SENSORS HAVE REVOLUTIONIZED LONGER TERM PATIENT MONITORING BUT THEY ARE NOT WELL STUDIED AND PRESENT INFECTION RISK.THE ADVANTAGE OF COLLABORATING WITH THE GOVERNMENT ON THIS ENDEAVOR IS THAT IF SUCCESSFUL IT CAN PROVIDE MEDICAL GRADE CLINICALLY BACKED AFFORDABLE ACCESSIBLE FLEXIBLE AND DISPOSABLE WEARABLE TECHNOLOGY TO AMERICANS. A SUCCESSFUL PROJECT WOULD RESULT IN STATE OF THE ART ALGORITHMS FOR BOTH NONINVASIVE CARDIAC OUTPUT MONITORING AND LCOS PREDICTIONS FOLLOWING SURGERY. ADDITIONALLY NONINVASIVE QUAD MODAL WEARABLE HARDWARE (ETATTOO) WOULD BE PRODUCED TO MEASURE PHYSIOLOGICAL PARAMETERS. THERE IS GREAT COMMERCIALIZATION AND MARKET POTENTIAL FOR THE ETATTOO WEARABLE MONITORING DEVICE (1) THE DEVICE COVERS BOTH PEDIATRIC AND ADULT MARKETS (2) THE AI ALGORITHMS CAN BE STANDALONE OR LICENSED TO OTHER COMPANIES AND (3) THE ETATTOO DEVICE HARDWARE CAN BE USED FOR APPLICATIONS OUTSIDE OF LCOS PREDICTION.

A BRAIN ATLAS FOR MAPPING CONNECTIVITY IN FOCAL EPILEPSY

NEXT GENERATION DNMT1 DEPLETION THERAPY FOR LEUKEMIA

ROLE OF STRESS IN THE DEGRADATION OF INTESTINAL IGA AND INTESTINAL HEALTH

RENAL SYMPATHETIC DENERVATION IN CONGESTIVE HEART FAILURE

REDUCING ANTIMICROBIAL OVERUSE THROUGH TARGETED THERAPY FOR PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA - PROJECT SUMMARY/ABSTRACT COMMUNITY-ACQUIRED PNEUMONIA (CAP) IS A LEADING CAUSE OF HOSPITALIZATIONS AND INPATIENT MORBIDITY AND MORTALITY IN THE UNITED STATES. HOWEVER, THE ETIOLOGICAL DIAGNOSIS OF CAP IS CHALLENGING AS >75% OF CULTURES ARE NEGATIVE AND A CAUSATIVE PATHOGEN CANNOT BE IDENTIFIED. THE ATS/IDSA GUIDELINES RECOMMEND THAT EXTENDED SPECTRUM EMPIRIC ANTIMICROBIAL THERAPY BE LIMITED TO ADULT PATIENTS WITH RISK FACTORS FOR RESISTANT PATHOGENS. HOWEVER, IN THE FACE OF NEGATIVE CULTURES AND DIAGNOSTIC UNCERTAINTY, CLINICIANS ARE OFTEN UNCOMFORTABLE DE- ESCALATING THERAPY, BECAUSE NARROWING TREATMENT COULD RESULT IN INADEQUATE COVERAGE. THE PROLONGATION OF EMPIRIC TREATMENT HAMPERS ANTIMICROBIAL STEWARDSHIP EFFORTS AND ENCOURAGES THE DEVELOPMENT OF ANTIMICROBIAL RESISTANCE. OUR OVERALL GOAL IS TO IMPROVE ANTIMICROBIAL PRESCRIBING FOR PATIENTS WITH CAP BY EMPHASIZING PATHOGEN-DIRECTED THERAPY. AN ACCURATE PATHOGENIC DIAGNOSIS COULD CONTRIBUTE TO ANTIMICROBIAL STEWARDSHIP IN 2 WAYS: 1) BY ALLOWING FOR INITIAL NARROW-SPECTRUM THERAPY AND 2) BY PROVIDING CONFIDENCE WHEN DE-ESCALATING THERAPY FOLLOWING NEGATIVE CULTURES. RAPID DIAGNOSTIC ASSAYS HAVE THE POTENTIAL TO PROVIDE ACCURATE RESULTS WITHIN HOURS AND THEREBY REDUCE THE DURATION OF EXPOSURE TO EXTENDED SPECTRUM EMPIRIC THERAPY. MULTIPLE OBSERVATIONAL STUDIES HAVE DEMONSTRATED THAT USE OF MOLECULAR DIAGNOSTIC ASSAYS IS ASSOCIATED WITH FAVORABLE OUTCOMES INCLUDING A REDUCTION IN THE TOTAL DURATION OF ANTIMICROBIAL USE AND LENGTH OF STAY IN THE HOSPITAL. THE MOST RECENT ANTIMICROBIAL STEWARDSHIP IMPLEMENTATION GUIDELINES RECOMMEND THE USE OF RAPID VIRAL TESTING FOR RESPIRATORY PATHOGENS AS A MEANS TO REDUCE THE USE OF INAPPROPRIATE ANTIBIOTICS. HOWEVER, THESE RECOMMENDATIONS ARE BASED ON LOW QUALITY EVIDENCE AND IT IS UNKNOWN WHETHER MORE WIDESPREAD EARLY DIAGNOSTIC TESTING COULD REDUCE THE USE OF BROAD-SPECTRUM ANTIBIOTICS AND/OR PROMPT INITIATION OF ANTIVIRAL THERAPY. DE-ESCALATION FOLLOWING NEGATIVE BACTERIAL CULTURES IS ANOTHER ANTIMICROBIAL STEWARDSHIP TARGET. WHILE MOST DE-ESCALATION FOLLOWS IDENTIFICATION OF A SUSCEPTIBLE PATHOGEN, THE ATS/IDSA GUIDELINES ALSO RECOMMEND DE-ESCALATION AT 48 HOURS IF CULTURES ARE NEGATIVE. HOWEVER, THESE RECOMMENDATIONS ARE ALSO BASED ON OBSERVATIONAL STUDIES. WE PROPOSE A LARGE, MULTICENTER 2 X 2 FACTORIAL CLUSTER RANDOMIZED CONTROLLED TRIAL TO TEST BOTH APPROACHES TO REDUCING THE USE OF BROAD-SPECTRUM ANTIBIOTICS IN PATIENTS WITH CAP: A) ROUTINE USE OF RAPID DIAGNOSTIC TESTING AT THE TIME OF ADMISSION AND B) PHARMACIST-LED DE-ESCALATION AFTER 48 HOURS FOR CLINICALLY STABLE PATIENTS WITH NEGATIVE CULTURES. OUR STUDY WILL BE THE LARGEST RANDOMIZED TRIAL TO DETERMINE THE IMPACT OF RAPID DIAGNOSTIC TESTING ON ANTIMICROBIAL STEWARDSHIP AND PATIENT OUTCOMES. OUR RANDOMIZED TRIAL DESIGN WILL ALLOW US TO ESTABLISH CAUSALITY AND DETERMINE WHETHER BROAD SPECTRUM ANTIBIOTICS CAN BE SAFELY DE-ESCALATED IN STABLE PATIENTS. FINDINGS FROM OUR PROPOSED TRIALS WILL GENERATE IMPORTANT NEW KNOWLEDGE ABOUT PATHOGEN TARGETED THERAPY AND ANTIMICROBIAL DE-ESCALATION IN PATIENTS WITH CAP. SPECIFICALLY, KNOWLEDGE GAINED FROM THIS PROPOSAL WILL ALLOW PHYSICIANS TO LIMIT THE USE OF BROAD-SPECTRUM ANTIMICROBIALS AND INITIATE TARGETED THERAPY.

REDUCING ANTIMICROBIAL OVERUSE IN HCAP THROUGH PERSONALIZED ANTIMICROBIAL RECOMMENDATIONS

NOVEL SPLICEOSOMAL DEFECTS IN MYELODYSPLASTIC SYNDROMES

A PHASE I ASSESSMENT OF MESENCHYMAL STEM CELLS FOR THE TREATMENT OF MULTIPLE SCLEROSIS

AWARENESS AND ACCESS TO CARE FOR CHILDREN AND YOUTH WITH EPILEPSY

NEURONAL PROTECTIVE NANOPARTICLES FOR TREATING ACUTE SCI

UNDERSTANDING THE EFFECTS OF DEEP BRAIN STIMULATION ON CORTICAL PROCESSING

IRAKM AND MINCLE IN ALD

COMPENSATORY STEROIDOGENESIS MECHANISMS IN CASTRATION-RESISTANT PROSTATE CANCER

AWARENESS AND ACCESS TO CARE FOR CHILDREN AND YOUTH WITH EPILEPSY

RNA HELICASE MUTATIONS IN MYELODYSPLASTIC SYNDROME: NEW THERAPEUTIC TARGET

TROOP READINESS EVALUATION WITH AUGMENTED REALITY RETURN-TO-DUTY (READY) SYSTEM.

IL-10-DEPENDENT REGULATION OF VIRAL-INDUCED DEMYELINATION

EXTRAPULMONARY MICROVASCULAR DYSFUNCTION IN PULMONARY ARTERIAL HYPERTENSION

MODELING THE DISEASE BURDEN AND COST-EFFECTIVENESS OF SCREENING AND TREATMENT FOR NON-ALCOHOLIC FATTY LIVER DISEASE IN TYPE 2 DIABETES PATIENTS

DEVELOPING NEUPRON FOR ACUTE SPINAL CORD INJURY: IDENTIFYING SURROGATE BIOMARKERS FOR TREATMENT EFFICACY

REGULATION OF B CELL ACTIVATION IN LUPUS

STRENGTHENING THE ANTIMICROBIAL ARSENAL OF THE INTESTINAL EPITHELIUM TO COUNTERACT MULTIDRUG-RESISTANT ENTERIC PATHOGENS

TARGETING THE INNATE IMMUNE RESPONSE TO COMBAT ANTIBIOTIC-RESISTANT BACTERIAL INFECTIONS

COLLABORATIVE RESEARCH: FRAMEWORKS: INTEROPERABLE HIGH-PERFORMANCE CLASSICAL, MACHINE LEARNING AND QUANTUM FREE ENERGY METHODS IN AMBER -WITH SUPPORT FROM THE OFFICE OF ADVANCED INFRASTRUCTURE AND THE DIVISION OF CHEMISTRY AT NSF, PROFESSOR MERZ AND HIS GROUP WILL WORK ON MOLECULAR SIMULATION CYBERINFRASTRUCTURE. MOLECULAR SIMULATIONS HAVE BECOME AN INVALUABLE TOOL FOR RESEARCH AND TECHNOLOGY DEVELOPMENT IN CHEMICAL, PHARMACEUTICAL, AND MATERIALS SCIENCES. WITH THE AVAILABILITY OF SPECIALIZED HARDWARE SUCH AS GRAPHICS PROCESSING UNITS (GPUS), MOLECULAR DYNAMICS SIMULATIONS USING CLASSICAL OR MOLECULAR MECHANICAL FORCE FIELDS HAVE REACHED THE SPATIAL AND TEMPORAL SCALES NEEDED TO ADDRESS IMPORTANT REAL-WORLD PROBLEMS IN THE CHEMICAL AND BIOLOGICAL SCIENCES. FREE ENERGY SIMULATIONS ARE A PARTICULARLY IMPORTANT AND CHALLENGING CLASS OF MOLECULAR SIMULATIONS THAT ARE CRITICAL TO GAIN A PREDICTIVE UNDERSTANDING OF CHEMICAL PROCESSES. FOR EXAMPLE, FREE ENERGY METHODS CAN PREDICT THE BARRIER HEIGHT AND RATES FOR CHEMICAL REACTIONS, WHETHER A REACTION WILL OCCUR, OR HOW TIGHTLY A DRUG BINDS TO A TARGET. THESE PREDICTIONS ARE EXTREMELY VALUABLE FOR THE DESIGN OF NEW CATALYTIC AGENTS OR DRUGS. HOWEVER, THE PREDICTIVE CAPABILITY OF FREE ENERGY SIMULATIONS IS SENSITIVE TO THE UNDERLYING MODEL THAT DESCRIBES THE INTER-ATOMIC POTENTIAL ENERGY AND FORCES. ACCURATE FREE ENERGY SIMULATIONS OF CHEMICAL PROCESSES REQUIRE POTENTIAL ENERGY MODELS THAT CAPTURE THE ESSENTIAL PHYSICS AND CAN RESPOND TO CHANGES IN THE CHEMICAL ENVIRONMENT, BUT CONVENTIONAL FORCE FIELD MODELS ARE UNSUITABLE FOR MANY PROCESSES INVOLVING BOND BREAKING AND FORMATION AS SEEN, FOR EXAMPLE, IN CATALYST DESIGN. CONSEQUENTLY, THERE IS GREAT NEED TO EXTEND THE SCOPE OF FREE ENERGY METHODS BY ENABLING THE USE OF A BROADER RANGE OF POTENTIAL ENERGY MODELS THAT ARE MORE ACCURATE AS WELL AS REACTIVE AND/OR CAPABLE OF QUANTUM MECHANICAL MANY-BODY POLARIZATION AND CHARGE TRANSFER. THE CYBERINFRASTRUCTURE CREATED BY THIS PROJECT ALLOWS FOR THE ROUTINE APPLICATION OF FREE ENERGY METHODS, USING QUANTUM MECHANICS, MACHINE LEARNING, REACTIVE AND CLASSICAL POTENTIALS TO A MYRIAD OF IMPORTANT PROBLEMS THAT ADVANCE THE STATE-OF-THE ART IN THE BIOLOGICAL AND CHEMICAL SCIENCES. THE TOOLS CAN BE APPLIED BY A RANGE OF SCIENTISTS TO ADDRESS FUNDAMENTAL PROBLEMS OF NATIONAL INTEREST, FOR EXAMPLE, IN THE DESIGN OF DRUGS AGAINST ZOONOTIC DISEASES (E.G., COVID-19), THE DESIGN OF MATERIALS WITH NOVEL FUNCTIONS AND IN THE DESIGN OF IMPROVED BATTERIES. GIVEN THE SOPHISTICATION OF THE METHODS EMPLOYED, EDUCATION OF A DIVERSE POOL OF CHEMICAL, BIOLOGICAL AND COMPUTER SCIENTISTS TO ADVANCE THIS FIELD IS ESSENTIAL AND IS ADDRESSED IN THIS PROJECT, THEREBY TRAINING THE NEXT GENERATION OF COMPUTATIONAL SCIENTISTS THAT WILL FORM THE BACKBONE OF THE WORK FORCE OF THE FUTURE. THE PROJECT DEVELOPS ACCURATE AND EFFICIENT FREE ENERGY SOFTWARE WITHIN A POWERFUL NEW MULTISCALE MODELING FRAMEWORK IN THE AMBER SUITE OF PROGRAMS FOR APPLICATIONS IN CHEMISTRY, BIOLOGY, AND MATERIALS SCIENCE. THE MULTISCALE FRAMEWORK ENABLES THE DESIGN AND USE OF NEW CLASSES OF MIXED-METHOD FORCE FIELDS THAT INVOLVE INTEROPERABILITY BETWEEN SEVERAL EXISTING AND EMERGING REACTIVE, MACHINE LEARNING AND QUANTUM MANY-BODY POTENTIALS. THESE POTENTIALS HAVE ENHANCED ACCURACY, ROBUSTNESS, AND PREDICTIVE CAPABILITY COMPARED TO CLASSICAL MOLECULAR MECHANICAL FORCE FIELDS AND ENABLE THE STUDY OF CHEMICAL REACTIONS AND CATALYSIS. THE CYBERINFRASTRUCTURE SUPPORTS INNOVATIVE MULTI-LAYERED HYBRID POTENTIALS THAT CAN BE CUSTOMIZED TO MEET THE NEEDS OF COMPLEX APPLICATIONS IN BIOTECHNOLOGY DEVELOPMENT, ENZYME DESIGN AND DRUG DISCOVERY. A ROBUST ENDPOINT BOOK-ENDING APPROACH THAT LEVERAGES THE GPU-ACCELERATED CAPABILITY OF THE AMBER MOLECULAR DYNAMICS ENGINE IS USED TO REACH THESE GOALS. SPECIFICALLY, THE OPEN-SOURCE HIGH-PERFORMANCE SOFTWARE FOR FREE ENERGY SIMULATIONS IS DESIGNED FOR MULTI-LAYERED HYBRID POTENTIALS USING COMBINATIONS OF LINEAR-SCALING MANY-BODY QUANTUM MECHANICAL METHODS VIA THE GPU-ACCELERATED QUICK PACKAGE, SCALABLE REACTIVE REAXFF FORCE FIELDS VIA THE PUREMD PACKAGE, AS WELL AS THE RECENTLY DEVELOPED DEEPMD-SE, ANAKIN-ME (ANI) AND AP-NET FAMILIES OF MACHINE LEARNING POTENTIALS. THE CYBERINFRASTRUCTURE IS BUILT UPON THE EXISTING HIGH-PERFORMANCE CUDA MD ENGINE IN AMBER AND EXTENDS IT TO A BROAD RANGE OF GPU-ACCELERATED ARCHITECTURES USING INDUSTRY-STANDARD PROGRAMMING MODELS. SCALABILITY IS ENSURED USING INNOVATIVE PARALLEL ALGORITHMS. HIGH IMPACT IS ACHIEVED BY LEVERAGING AMBER'S BROAD USER BASE TO EXPAND THE SCOPE AND SUCCESS OF FE APPLICATIONS. IN THIS WAY, THE PROJECT LEVERAGES EXISTING RECOGNIZED CAPABILITIES AND ACTIVELY ENGAGES A DIVERSE TEAM OF COLLABORATORS AND THE BROADER MOLECULAR SIMULATIONS COMMUNITY. THE CYBERINFRASTRUCTURE DELIVERED BY THE PROJECT ENABLES A WIDE RANGE OF NEW AND ENHANCED APPLICATIONS FOR A BROAD COMMUNITY OF USERS IN ACADEMIA, INDUSTRY, AND NATIONAL LABORATORIES. THESE APPLICATIONS INCLUDE DRUG DISCOVERY, ENZYME CATALYSIS, AND BIOMATERIALS DESIGN. THE AMBER SUITE OF PROGRAMS HAS A LONG-STANDING EXTENSIVE WORLDWIDE USERBASE, AND IS WIDELY USED ON NATIONAL PRODUCTION CYBERINFRASTRUCTURE. THE ENHANCEMENT OF AMBER AS AN ESTABLISHED, PROVEN SUSTAINABLE, AND WIDELY USED PACKAGE WILL ENSURE THAT THE SOFTWARE HAS A BROAD IMPACT WELL BEYOND THE END OF THE PROJECT. THE PROJECT WILL ALSO TRAIN A DIVERSE POPULATION OF STUDENTS AND RESEARCHERS IN THEORY, PROGRAMMING, COMPUTATIONAL CHEMISTRY/BIOLOGY, COMPUTER SCIENCE, SCIENTIFIC WRITING, AND COMMUNICATION. THIS AWARD BY THE OFFICE OF ADVANCED CYBERINFRASTRUCTURE IS JOINTLY SUPPORTED BY THE DIVISION OF CHEMISTRY WITHIN THE NSF DIRECTORATE FOR MATHEMATICAL AND PHYSICAL SCIENCES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

FUNCTIONAL INHIBITION OF DEUBIQUITYLASE HAUSP TO DISRUPT GLIOBLASTOMA STEM CELLS

ALCOHOL-INDUCED NEUROGENESIS

VASCULAR PLAQUE DETERMINATION FOR STROKE RISK ASSESSMENT

CONNEXINS AND GLIOBLASTOMA PROGRESSION

HYPOXIA REGULATES NOTCH TURNOVER IN GLIOMA STEM CELLS THROUGH VASORIN

MICRORNAS AS CRITICAL REGULATORS OF REMYELINATION IN MULTIPLE SCLEROSIS

GLIOBLASTOMA STEM CELL-DERIVED PERICYTES AND CANCER INVASION

MICROBIAL TRIMETHYLAMINE LYASES AND ATHEROSCLEROSIS

DEVELOPING PRO-NP FOR ACUTE SPINAL CORD INJURY

PORTABLE BIOCHIP FOR RAPID DETECTION OF BIOWARFARE AGENTS

REGULATION OF LIFESPAN

NON-CANONICAL REGULATION OF GRK2 BY TNFALPHA IMPAIRS BETAAR FUNCTION

BETA ADRENERGIC RECEPTOR RESENSITIZATION IN ASTHMA

MOLECULAR MECHANISMS IN CORIN ACTIVATION

TARGETING NAV1.5 TRAFFICKING AS A THERAPY FOR LETHAL GENETIC CARDIAC ARRHYTHMIAS

MECHANISM OF ATHEROPROTECTIVE FUNCTION OF AKT3 KINASE

OXIDANT RESISTANT APOA1 IN REVERSE CHOLESTEROL TRANSPORT, INFLAMMATION AND ATHEROSCLEROSIS

"NOVEL GENETIC MODELS TO STUDY THE ROLE OF INFLAMMATION IN BRAIN INJURY-INDUCED ALZHEIEMER'S PATHOLGY"

AN INNOVATIVE REPAIR STRATEGY TO TARGET INHIBITORY GLIA SCARS AFTER SPINAL CORD INJURY

APOLIPOPROTEIN F ENHANCES HDL FUNCTION

THE QUANTIFICATION OF VISUAL FUNCTION AND POSTURAL STABILITY UNDER SINGLE AND DUAL TASK CONDITIONS USING MOBILE TECHNOLOGY

IDENTIFYING BIOMARKERS AND DISSECTING COMBINATORIAL SYNERGIES TO IMPROVE IMMUNE CHECKPOINT INHIBITOR RESPONSE IN BLADDER CANCER

OHIO CONSORTIUM CLINICAL CENTER FOR THE NHLBI PREVENTION AND EARLY TREATMENT OF A

INTUITIVE ULTRASOUND-BASED UPPER LIMB PROSTHETIC CONTROL AND FEEDBACK UTILIZING TARGETED REINNERVATION FOR NEUROMA PAIN

PHYSIOLOGICALLY RELEVANT PROSTHETIC LIMB MOVEMENT FEEDBACK FOR UPPER AND LOWER EXTREMITY AMPUTEES

LOCAL INHIBITION OF COMPLEMENT TO IMPROVE MSC-BASED THERAPY FOR DIABETES

ANTIBACTERIAL FUNCTIONS OF CAP-D3/CONDENSIN II IN THE COLONIC EPITHELIUM

INVESTIGATING THE BIOLOGICAL MECHANISMS AND THERAPEUTIC RELEVANCE OF THE SLC1A1 AMINO ACID TRANSPORTER IN KIDNEY CANCER

THE NF-I/A TRANSCRIPTION FACTOR REGULATES AN HIF-INDEPENDENT FATTY ACID METABOLISM PROGRAM IN KIDNEY CANCER

METHYLDB-SARC AND CLASSSARC: A UNIFIED COLLABORATIVE NETWORK FOR CENTRALIZED SARCOMA METHYLOMICS-BASED DATABASE AND CLASSIFIER

MECHANISM AND THERAPEUTIC POTENTIAL OF PTEN-REGULATED MDSCS IN GLIOBLASTOMA

HEALTH CARE AND OTHER FACILITIES

EFFECTIVENESS OF ACUPRESSURE TREATMENT FOR PAIN MANAGEMENT AND FATIGUE RELIEF IN GULF WAR VETERANS

ADVANCED NURSING EDUCATION - SEXUAL ASSAULT NURSE EXAMINERS PROGRAM - SEXUAL ASSAULT NURSE EXAMINERS (SANES) ARE VITAL TO SURVIVORS OF SEXUAL ASSAULT AND DOMESTIC VIOLENCE. SANES PROVIDE TRAUMA-INFORMED, SPECIALIZED CARE TO SUPPORT SURVIVORS, ASSESS FOR MEDICAL NEEDS AND IF INDICATED, COLLECT EVIDENCE IN A RESPECTFUL MANNER THAT PREVENTS REVICTIMIZATION. UNFORTUNATELY, MOST COUNTIES IN OHIO HAVE NO SANES AVAILABLE. IN A 10-COUNTY AREA OF NORTHEAST OHIO, THERE ARE ONLY 3 SANE CERTIFIED RNS AND 7 OF THOSE COUNTIES HAVE NO SANE SERVICES. THIS PROJECT AIMS TO INCREASE THE AVAILABILITY OF SANE TRAINED NURSES IN THE 10-COUNTY AREA BY CONNECTING WITH STAKEHOLDERS, RECRUITING NURSES TO ATTEND SANE TRAININGS CLOSE TO WHERE THEY LIVE AND WORK, HIRING ADDITIONAL SANES TO PROVIDE SERVICES TO MEDICALLY UNDERSERVED POPULATIONS AND CREATING A NETWORK OF SANES TO SUPPORT AND MENTOR ONE ANOTHER. TRAINEES AND NEWLY HIRED SANES WILL BE ASSESSED FOR HEALTH-RELATED SOCIAL NEEDS AND MITIGATION PLANS WILL BE DEVELOPED TO DISMANTLE SYSTEMIC BARRIERS PREVENTING THEM FROM ACHIEVING PERSONAL AND PROFESSIONAL SUCCESS. IN ADDITION TO INCREASING THE ACCESS TO SANES, A COMMUNITY HEALTH NEEDS ASSESSMENT WILL BE CONDUCTED RELATED TO SANE SERVICES IN THE TARGET AREA. RECOMMENDATIONS WILL BE DEVELOPED WITH COMMUNITY SERVICE AGENCIES, COMMUNITY MEMBERS AND OTHER STAKEHOLDERS TO PRIORITIZE INTERVENTIONS. ACTIONS WILL BE TRACKED, AND PROGRESS REPORTED OUT TO THE COMMUNITY. FINALLY, A WELLNESS SERIES WILL BE DEVELOPED TO SUPPORT SANE RETENTION. THE SERIES WILL FOCUS ON THE DIMENSIONS OF WELLNESS, HOW THE WORK OF SANES IMPACTS WELLNESS AND WHAT SANES CAN DO MANAGE THE DELETERIOUS EFFECTS OF VICARIOUS TRAUMA.

MECHANISMS AND REGULATION OF PROGRAMMED TRANSLATIONAL READTHROUGH

THERAPEUTIC STRATEGIES TO DISRUPT CX26-FAK-NANOG COMPLEX TO ATTENUATE CANCER STEM CELL SELF-RENEWAL AND TRIPLE-NEGATIVE BREAST CANCER PROGRESSION

IDENTIFYING THE NEURAL SIGNATURE OF EXERCISE TO ADVANCE TREATMENT OF PD COGNITIVE DECLINES

SPECIFIC-SIZED HA35 IN PREVENTING THE TRANSITION FROM PREDIABETES TO DIABETES

TARGETING A NOVEL T-CELL INHIBITORY RECEPTOR AND DEVELOP NOVEL IMMUNOPREVENTION APPROACHES FOR MELANOMA

THERAPEUTIC STRATEGIES TO DISRUPT CX26-FAK-NANOG COMPLEX TO ATTENUATE CANCER STEM CELL SELF-RENEWAL AND TRIPLE-NEGATIVE BREAST CANCER PROGRESSION

TARGETING PARIETAL EPITHELIAL CELLS IN FSGS

INHIBITION OF SCARRING FIBROSIS AND NEOVASCULARIZATION AFTER CORNEAL INJURY

THERAPEUTIC IMMUNOSTIMULATORY MICROBES FOR TREATMENT OF OVARIAN CANCER

ENHANCEMENT OF NOD2 FUNCTION AS A NOVEL THERAPY FOR INFLAMMATORY BOWEL DISEASE

NOVEL NUCLEAR LOCALIZATION OF THE COMPLEMENT REGULATOR CD55 IDENTIFIES A NEW HOOK FOR DISRUPTING OVARIAN CANCER PROGRESSION

EXPLOITING EPIGENETIC DYSREGULATION TO IDENTIFY TARGETABLE VULNERABILITIES IN CCRCC

GENETICALLY DIRECTED HSD3B1 THERAPEUTICS FOR METASTATIC PROSTATE CANCER

FROM WASTE TO UV ARMOR: DEVELOPMENT AND OPTIMIZATION OF COST-EFFECTIVE BIOCOMPATIBLE GRAPHENE QUANTUM DOTS FOR MELANOMA PREVENTION.

PHASE II, IL-1 TRAP FOR TREATMENT OF FAMILIAL MEDITERRANEAN FEVER

OPTIMIZING SOFT TISSUE MANAGEMENT AND SPACER DESIGN IN SEGMENTAL BONE DEFECTS

ACCELERATION OF HEPATIC FIBROSIS BY ALCOHOL: ROLE OF ADENOSINE

MECHANISM(S) OF SUPPRESSION OF LUPUS IN GENETICALLY PREDISPOSED MALES

WAVE3 IS A BIOMAKER FOR BREAST CANCER PROGRESSION AND METASTASIS

INTERROGATING THE THERAPEUTIC RELEVANCE OF TARGETING THE ANTIAPOPTOTIC BCL-XL PROTEIN IN KIDNEY CANCER

INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY FOR OPHTHALMIC SURGERY

SPECIFIC-SIZED HA35 IN PREVENTING THE TRANSITION FROM PREDIABETES TO DIABETES

INHIBITING DEMYELINATION RESCUES SYNAPSE LOSS IN MULTIPLE SCLEROSIS

TELOMERE END-PROTECTION AND THE ANTI-CHECKPOINT -THE DNA OF ORGANISMS FROM YEAST TO HUMANS IS PACKAGED IN LINEAR CHROMOSOMES, THE ENDS OF WHICH ARE CALLED TELOMERES. WHEN CHROMOSOMES ARE BROKEN, THE BROKEN ENDS CAN BE DEGRADED OR FUSED WITH OTHER CHROMOSOMES TO CAUSE MUTATIONS AND DISEASES SUCH AS CANCER. BROKEN CHROMOSOMES AND TELOMERES BOTH PRESENT DNA ENDS, BUT TELOMERES HAVE SPECIAL DNA SEQUENCES AND PROTEINS BOUND TO THEM THAT BLOCK DEGRADATION AND FUSION. THE LABORATORY RECENTLY DISCOVERED A NEW WAY THAT CELLS CAN DISTINGUISH A BROKEN DNA END FROM A TELOMERE: THE CCQ1 PROTEIN PROTECTS TELOMERE DNA FROM BEING DEGRADED. THIS PROJECT WILL INVESTIGATE HOW CCQ1 ACCOMPLISHES THIS PROTECTION AND WHAT OTHER PROTEINS ACT WITH CCQ1 IN THE PROCESS. TELOMERES PLAY IMPORTANT ROLES IN AGING AND CANCER, AND RESULTS FROM THIS RESEARCH WILL PROVIDE FUNDAMENTAL NEW INFORMATION THAT CAN BE APPLIED TO MEDICINE, AGRICULTURE AND BIOTECHNOLOGY. THIS PROJECT INCLUDES COMMUNITY OUTREACH ACTIVITIES THAT PROVIDE LABORATORY RESEARCH AND TRAINING OPPORTUNITIES FOR UNDERGRADUATE AND HIGH SCHOOL STUDENTS DURING THE SUMMER AND SCHOOL YEAR, SUMMER LECTURES ON A BROAD RANGE OF BIOLOGICAL TOPICS FOR THESE STUDENTS, AND MENTORING OPPORTUNITIES FOR EXPERIENCED LABORATORY MEMBERS. TELOMERES ARE DNA REPEAT TRACTS BOUND BY A SET OF PROTEINS CALLED ?SHELTERIN?. THIS PROJECT BUILDS ON PRIOR RESEARCH ON THE ROLE OF INDIVIDUAL SHELTERIN PROTEINS IN DISTINGUISHING A SHORT TELOMERE FROM A DOUBLE STRAND BREAK (DSB), AND USES A ?PROTO-TELOMERE? SYSTEM IN THE FISSION YEAST SCHIZOSACCHAROMYCES POMBE WHERE AN INDUCIBLE NUCLEASE CUTS DNA BEARING TELOMERE REPEATS TO GENERATE A SHORT TELOMERE OR CREATES A CONTROL DSB WITHOUT TELOMERE REPEATS. THE RESULTS YIELDED A NOVEL FUNCTION FOR THE SHELTERIN PROTEIN CCQ1 IN PROTECTING NEW TELOMERES FROM NUCLEASES. A SECOND, SURPRISING DISCOVERY INVOLVED TELOMERE ?ANTI-CHECKPOINT? ACTIVITY, WHICH PREVENTS TELOMERES FROM ACTIVATING THE DAMAGE RESPONSE TO DSBS. INITIAL FINDINGS INDICATE THAT CCQ1 ANTI-CHECKPOINT FUNCTION IS SEPARABLE FROM END-PROTECTION, AND IDENTIFY OTHER GENES THAT ARE REQUIRED FOR THE ANTI-CHECKPOINT. USING A COMBINATION OF GENETICS, CHROMATIN IMMUNOPRECIPITATION AND MICROSCOPY, AIM 1 WILL EXPLORE AND TEST CANDIDATE END-BINDING PROTEINS FOR PROTECTION OF THE SHORT TELOMERE. AIM 2 WILL TEST THE ROLE OF CCQ1 AND THE DISCOVERED GENES IN REGULATING ASSEMBLY OF THE DNA DAMAGE SIGNALING COMPLEX. THE OUTCOMES ARE EXPECTED TO PROVIDE NOVEL INSIGHTS INTO THE LONG-STANDING QUESTION OF HOW CELLS CAN DISTINGUISH BROKEN DNA ENDS FROM TELOMERES AND PROCESS THEM APPROPRIATELY TO MAINTAIN GENOME STABILITY AND CELLULAR HEALTH. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

MAGNETIC RESONANCE IMAGING-GUIDED TRANSCRIPTOMIC ANALYSIS OF SPINAL CORD NEURODEGENERATION AND DEMYELINATION IN MULTIPLE SCLEROSIS

PATIENT-CENTERED APPROACH TO REDUCING HARM FROM VTE

TELEHEALTH DELIVERY TREATMENT SLEEP DISTURBANCES YC WITH ASD

TRANSCRIPTION ELONGATION ON NUCLEOSOMAL TEMPLATES BY RNA POLYMERASE II

INVESTIGATING THE ROLE OF A NOVEL INHIBITORY RECEPTOR COMPLEX IN DRIVING T CELL DYSFUNCTION AND THERAPEUTIC RESISTANCE TOWARD IMMUNOTHERAPIES IN LUNG CANCER.

NEXT GENERATION NEUROIMAGING AT CLEVELAND CLINIC

ACQUISITION OF A MICRO-PET/CT SCANNER FOR PRECLINICAL AND TRANSLATIONAL RESEARCH

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

MULTIMODAL AI-BASED RENAL CANCER PATIENT CARE

THE TELOMERE ANTI-CHECKPOINT ACTIVITY

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - CLEVELAND CLINIC AKRON GENERAL’S (CCAG) WOMEN’S HEALTH CENTER (WHC) PROVIDED CARE FOR OVER 1300 PRENATAL VISITS OVER THE PAST 12 MONTHS. DURING THAT SAME TIMEFRAME, WE HAVE EXPANDED THE NUMBER OF CENTERING PREGNANCY PRENATAL GROUPS, ADDED ULTRASOUND AND FETAL MONITORING CAPABILITIES SO PATIENTS DO NOT HAVE TO GO TO MULTIPLE LOCATIONS FOR CARE AND ARE INCREASING THE NUMBER OF COMMUNITY HEALTH WORKERS (CHWS) FROM 1 TO 3. YET, THERE CONTINUES TO BE INCREASING DEMAND FOR THIS VITAL COMMUNITY RESOURCE. WE ARE LOOKING TO EXPAND OUR PROGRAM TO MEET THIS UNMET NEED. IN ORDER TO EXPAND OUR PROGRAM TO IMPROVE ACCESS, WE MUST MOVE OUR PRIMARY SITE OF CARE FROM THE 2ND FLOOR TO THE 1ST FLOOR OF THE CCAG AKRON HEALTH CENTER. THIS 1ST FLOOR SPACE IS MUCH BIGGER, BUT WILL REQUIRE SOME RENOVATION AND NEW EQUIPMENT, WHICH WE ARE ASKING FOR YOUR SUPPORT. THE OFFICE LOCATION AND LARGER SPACE WILL ALLOW MORE PATIENTS WHO LIVE IN THE COMMUNITIES WITH THE HIGHEST DISPARITIES IN MATERNAL MORBIDITY/ INFANT MORTALITY GREATER ACCESS TO THE HIGHEST QUALITY OF PRENATAL CARE AND EVIDENCE-BASED WRAP AROUND SERVICES TO MITIGATE THE ADVERSE IMPACT OF THEIR HEALTH-RELATED SOCIAL NEEDS. IT WILL TAKE A COMMUNITY EFFORT TO ENSURE ALL PREGNANT PATIENTS AND THEIR BABIES ACHIEVE THE BEST OUTCOMES; AND OUR WOMEN’S HEALTH CENTER IS COMMITTED TO BEING AN ANCHOR FOR THIS EFFORT AND THE ENTRY POINT FOR PATIENTS TO RECEIVE VITAL CARE, INCLUDING COMMUNITY SUPPORT THROUGH THEIR PREGNANCIES. MOREOVER, THROUGH THE PATHWAYS COMMUNITY HUB MODEL, OUR COMMUNITY HEALTH WORKERS HELP PATIENTS IDENTIFY AND ADDRESS THEIR HEALTH-RELATED SOCIAL NEEDS. WE KNOW THAT A SIGNIFICANT CAUSE OF THE ADVERSE OUTCOMES WE ARE SEEING IN INFANT AND MATERNAL HEALTH ARE RELATED TO THESE SOCIAL DETERMINANTS OF HEALTH. FOR THAT REASON, CLEVELAND CLINIC IS INVESTING IN HIRING TWO ADDITIONAL CHWS, CERTIFIED THROUGH THE OHIO NURSING BOARD, IN ORDER TO BETTER ADDRESS SOCIAL DETERMINANTS OF HEALTH. THE FUNDING WILL COVER RENO VATION COSTS INCLUDING: DEMOLITION & CONCRETE, CARPENTRY & MILLWORK, FLOORING, PAINTING, WALLS, PLUMBING, HVAC & MECHANICAL, ELECTRICAL, SIGNAGE/PERMITS, DATA NETWORK (CABLING AND ROUTER NETWORK FOR ELECTRONIC MEDICAL RECORD TO BE USED IN ALL PATIENT EXAM AND TREATMENT AREAS), ARCHITECTURAL AND ENGINEERING, MANAGEMENT/CONTRACTOR. THE EQUIPMENT COST THE GRANT WILL COVER ARE: TWO ULTRASOUND MACHINES (GENERAL ELECTRIC MODEL E10), EXAM TABLES AND RELATED EQUIPMENT FOR PATIENT NEEDS, FIXTURES, HEPA FILTRATION, TEMPORARY CONSTRUCTION BARRIERS, TRASH DUMPSTERS, AND DISPOSAL DURING RENOVATION.

A GENETIC AND METABOLIC BASIS FOR HORMONALLY DRIVEN POSTMENOPAUSAL BREAST CANCER

AWARENESS AND ACCESS TO CARE FOR CHILDREN AND YOUTHS WITH EPILEPSY

INSULIN RESISTANCE IN PULMONARY ARTERIAL HYPERTENSION

THE DESCRIPTION & ASSESSMENT OF PRE & POST-ANALYTIC TESTING PARAMETERS IMPORTANT

TARGET HSD3B1- ASSOCIATED EXTRAGONADAL ANDROGEN BIOSYNTHESIS TO SENSITIZE LETHAL PROSTATE CANCER

STRATEGIES ENHANCING SPINAL PLASTICITY TO PROMOTE RECOVERY FROM SPINAL CORD INJURY

TARGETING SEROTONERGIC RECEPTORS TO TREAT SPINAL CORD INJURY

LONGITUDINAL EVALUATION OF THE RELATION OF IMAGING MEASURES TO COGNITIVE DECLINE IN MULTIPLE SCLEROSIS

ENGINEERED CARBON NANOMATERIALS FOR PREVENTION OF UV-INDUCED MELANOMAGENESIS

CORNEAL BASEMENT MEMBRANES AND INJURY-RELATED SCARRING. NEW AWARD.

TRANSLATABLE PEPTIDE COMBINED WITH EXERCISE

THE GENETICS AND EPIGENETICS OF INFLAMMATION IN TRAUMATIC BRAIN INJURY

NOVEL NUCLEAR LOCALIZATION OF THE COMPLEMENT REGULATOR CD55 IDENTIFIES A NEW HOOK FOR DISRUPTING OVARIAN CANCER PROGRESSION

PLATELET ERK5 REGULATES MYOCARDIAL INFARCT EXPANSION

INCRETIN MIMETICS AND THIAZOLIDINEDIONES AS THERAPY AGAINST EXCESSIVE AIRWAY MUCUS TO IMPROVE LUNG FUNCTION IN COPD PATIENTS 3/6/26: MOD P00001 TRANSFER AWARD TO CLEVELAND CLINIC FOUNDATION

MICROBIOTA IN INTESTINAL FIBROSIS

NEURAL AND BEHAVIORAL SEQUELAE OF BLAST-RELATED TRAUMATIC BRIAN-INJURY

LEVERAGING FOCAL ADHESION DEPENDENCIES IN CDH1-DEFICIENT LOBULAR BREAST CANCERS

CLEVELAND CLINIC NEVADA (CCN) ? DEMENTIA EDUCATION AND EMPOWERMENT INITIATIVE (DEEI) - CLEVELAND CLINIC NEVADA (CCN) – DEMENTIA EDUCATION AND EMPOWERMENT INITIATIVE (DEEI)

TARGETING ETHANOL-INDUCED GUT DYSBIOSIS WITH SYNBIOTICS TO TREAT ALCOHOLIC LIVER

EARLY RECOGNITION OF CHRONIC TRAUMATIC ENCEPHALOPATHY THROUGH FDDNP PET IMAGING

MENISCUS STATUS AND ACTIVITY LEVEL AFTER ACL

REQUIREMENT OF HYDROGEN SULFIDE FOR THE BENEFITS OF DIETARY SULFUR AMINO ACID RESTRICTION

PERIPHERAL TREM2 EPIGENETICS AND THE IMMUNE RESPONSE IN NEURODEGENERATIVE DISORDERS

IMPACT OF A TEAM-BASED APPROACH TO PRIMARY CARE: A NATURAL EXPERIMENT IN PRIMARY CARE REDESIGN

DEEP BRAIN STIMULATION OF TREATMENT OF TRAUMATIC BRAIN INJURY

APOLIPOPROTEIN A1 MODIFICATIONS RELATED TO COGNITIVE DECLINE IN TYPE 2 DIABETES AND PRECLINICAL ALZHEIMER'S DISEASE

DECIPHERING THE ROLE OF THE GUT AND TUMOR MICROBIOME ON OVARIAN CANCER PROGRESSION AND RESISTANCE TO CHEMOTHERAPY.

DECIPHERING THE ROLE OF THE GUT AND TUMOR MICROBIOME ON OVARIAN CANCER PROGRESSION AND RESISTANCE TO CHEMOTHERAPY.

NEUROMIMAGINGOF BRAIN INJURIES AND DISORDERS AT CLEVELAND CLINIC

USING LARGE OBSERVATIONAL DATASETS TO IMPROVE ANTIBIOTIC PRESCRIBING FOR COMMUNITY-ACQUIRED PNEUMONIA

AVIATION RESEARCH GRANT - CLEVELAND CLINIC FOUNDATION PROPOSAL DETERMINING THE LOSS OF CONSCIOUSNESS IN FIGHTERS AND THE DEVELOPMENT ASSOCIATED INJURY ASSESSMENT REFERENCE VALUES

MULTIPLE SCLEROSIS AS A PRIMARY DISEASE OF OLIGODENDROCYTES

EPIGENETIC CONTROL AND THE CHECKPOINT-EXEMPT STATUS OF TELOMERES

CLEVELAND CLINIC REHABILITATION RESEARCH PROGRAM

BIOMARKERS OF RESPONSE TO NEURORESTORATIVE THERAPIES IN CERVICAL SCI

A QUANTITATIVE TEST OF ON ORBIT EXERCISE COUNTERMEASURES FOR BONE DEMINERALIZATION

ENHANCING THE DETECTION AND MANAGEMENT OF MTBI IN MILITARY PERSONNEL

EVOLUTIONARY EXPERIMENTATION HIGHLIGHTS NOVEL THERAPEUTIC VULNERABILITIES IN ENDOMETRIAL CANCER

GONOCOCCAL ISOLATE SURVEILLANCE PROJECT

PATHOLOGY OF SLOWLY ENLARGING LESIONS IN MULTIPLE SCLEROSIS

IDENTIFYING BIOMARKERS AND DISSECTING COMBINATORIAL SYNERGIES TO IMPROVE IMMUNE CHECKPOINT INHIBITOR RESPONSE IN BLADDER CANCER

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

NHD PRECLINICAL SCANNER

INVESTIGATING THE IMPORTANCE OF THE GUT MICROBIAL ENDOCRINE ORGAN IN KIDNEY CANCER DEVELOPMENT AND THERAPEUTIC RESPONSE

INVESTIGATING THE IMPORTANCE OF THE GUT MICROBIAL ENDOCRINE ORGAN IN KIDNEY CANCER DEVELOPMENT AND THERAPEUTIC RESPONSE

MULTIADAPTIVE PLAN (MAP) IMRT TO ACCOMMODATE INDEPENDENT MOVEMENT OF THE PROSTATE AND PELVIC LYMPH NODES

OPTIMIZING MET-TARGETED THERAPY FOR LUNG CANCER PERSONALIZED TREATMENT

IDENTIFYING BIOMARKERS OF RESPONSE AND RESISTANCE TO IMMUNOTHERAPY IN BLADDER CANCER

PKN1 AS NOVEL THERAPEUTIC TARGET IN ADVANCED PROSTATE CANCER

EVALUATING XMRV AS AN INDICATOR OF PROSTATE CANCER RISK OR PROGRESSION

HEALTH CARE AND OTHER FACILITIES

BENCH-TO-BEDSIDE DEVELOPMENT OF SUPERIOR CAR T-CELL THERAPY FOR LEUKEMIA

TARGETING GENOMIC DRIVERS OF HURTHLE CELL THYROID CANCER VIA MTOR AND EIF2 INHIBITION

CLINICAL INTERVENTIONS TO INCREASE ORGAN PROCUREMENT

TROPHOBLASTS IN PREECLAMPSIA ASSOCIATED THROMBOTIC COMPLICATIONS

TRANSPLANTATION OF REPROGRAMMED AUTOLOGOUS STEM CELLS FOR CHRONIC PAIN

REGENERATIVE NANOTHERAPEUTICS FOR TISSUE REPAIR IN PROTEOLYTIC DISORDERS

CHARACTERIZING AND TARGETING THE MICROENVIRONMENTAL BARRIERS TO IMMUNOTHERAPEUTIC RESPONSE IN RENAL CELL CARCINOMA

PRE-CLINICAL TESTING OF LENALIDOMIDE AS PLEIOTROPIC THERAPEUTICS OF ALZHEIMER'S DISEASE

TRANSCRIPTION ELONGATION ON NUCLEOSOMAL TEMPLATES BY RNA POLYMERASE II

IMMUNE EVASION AS A MECHANISM OF CLONAL ESCAPE IN APLASTIC ANEMIA

UTILIZATION OF A NOVEL GENETICALLY ENGINEERED MOUSE MODEL TO ELUCIDATE THE ROLES OF THE EXTRACELLULAR MATRIX IN EPITHELIOID HEMANGIOENDOTHELIOMA PROGRESSION

DEVELOPMENT AND EVALUATION OF AGENTS FOR POOR PROGNOSTIC VERTEBRATE MODEL FOR EWING SARCOMA

TARGETING CITRON KINASE IN CASTRATION-RESISTANT PROSTATE CANCER: FROM MECHANISTIC INSIGHTS TO THERAPEUTIC OPPORTUNITIES

PREPARATION AND PLANNING FOR THE PROSPECTIVE RANDOMIZED IMAGE-GUIDED OPHTHALMIC SURGERY CLINICAL TRIALS

EXPLOITING ANDROGEN RECEPTOR'S ALLOSTERIC REGULATION TO DEVELOP NEXT-GEN PROSTATE CANCER THERAPEUTICS

CLEVELAND PRECISION MEDICINE CHRONIC KIDNEY DISEASE COHORT

1/2 POMALIDOMIDE FOR BLEEDING IN PATIENTS WITH HEREDITARY HEMORRHAGIC TELANGIECTASIA (HHT)

INDIVIDUALIZING DISEASE PREVENTION FOR MIDDLE-AGED ADULTS

NEUROTOXICITY OF MODERN ANTIRETROVIRAL DRUGS: CNS MITOCHONDRIAL AND IRON-METABOLIC DEFECTS AND HIV LATENCY

POLYHYDROXY FULLERENE SUNSCREEN FOR PREVENTING UV-INDUCED SKIN CANCER

PERIPHERAL NEUROINFLAMMATORY PREDICTORS OF SUICIDAL RISK AT TIME OF INPATIENT DISCHARGE IN ADOLESCENTS

TARGETING A NOVEL AGGF1 SIGNALING PATHWAY FOR THERAPY OF PULMONARY HYPERTENSION

MULTIMODAL NANOTHERAPY TO IMPROVE SURGICAL MESH OUTCOMES IN ORGAN PROLAPSE