Carnegie Mellon University

CATEGORY I: BRIDGES-2: SCALABLE CONVERGED COMPUTING, DATA, AND ANALYTICS FOR RAPIDLY EVOLVING SCIENCE AND ENGINEERING RESEARCH

PERPETUALLY AVAILABLE AND SECURE INFORMATION SYSTEMS

LEVERAGING ADVANCED ALGORITHMS, AUTONOMY, AND ARTIFICIAL INTELLIGENCE (A4I) TO ENHANCE NATIONAL SECURITY AND DEFENSE

QUALITY OF LIFE TECHNOLOGY ENGINEERING RESEARCH CENTER

TOWARD A DECADE OF PSLC RESEARCH: INVESTIGATING INSTRUCTIONAL SOCIAL AND LEARNER FACTORS IN ROBUST LEARNING THROUGH DATA-DRIVEN ANALYSIS AND MODELI

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

BRIDGES: FROM COMMUNITIES AND DATA TO WORKFLOWS AND INSIGHT

LIVER DISEASE CONSTITUTES AN URGENT PUBLIC HEALTH CHALLENGE BECAUSE UNLIKE MOST OTHER DISEASES DEATHS DUE TO LIVER DISEASE ARE RAPIDLY RISING. THIS INCREASE IS ADDING TO AN ALREADY ENORMOUS HEALTH BURDEN IN WHICH LIVER DISEASE CAUSES OVER 2 MILLION DEATHS EACH YEAR. AS JUST ONE EXAMPLE OF THE CHALLENGE OF LIVER DISEASE ACUTE LIVER FAILURE (ALF) LEADS TO LOST LIVER FUNCTION COAGULOPATHY ENCEPHALOPATHY AND HIGH PATIENT MORTALITY OF 40% TO 90%. IN ADDITION PATIENTS WITH LIVER DISEASE AWAITING TRANSPLANT FACE SEVERE SHORTAGES AND A LIFETIME OF SUFFERING UNDER IMMUNOSUPPRESSION. TO ADDRESS THIS MAJOR HEALTH CHALLENGE OUR LIVER IMMUNOCOMPETENT VOLUMETRIC ENGINEERING (LIVE) PROPOSAL UNITES WORLD LEADERS IN 3D BIOPRINTING LIVER TISSUE ENGINEERING LIVER AND STEM CELL BIOLOGY 16 TO 22 AND LIVER HEALTH DISPARITIES WITH TWO OF THE WORLDS HIGHEST VOLUME LIVER TRANSPLANT CENTERS. TOGETHER WE WILL SOLVE CRITICAL BARRIERS IN BIOPRINTING AND HUMAN CELL SOURCING TO BUILD 3D PRINTED LIVER THAT WILL OBVIATE THE NEED FOR SYSTEMIC IMMUNOSUPPRESSION AND REPLACE ORGAN TRANSPLANTATION WITH A TRUE CURE FOR LIVER DISEASE NOT JUST FOR SOME BUT FOR ALL PATIENTS.

HIGHER EDUCATION EMERGENCY RELIEF FUND - INSTITUTIONAL PORTION

UNIVERSITY TRANSPORTATION CENTERS

ARTIFICIAL INTELLIGENCE ENABLED ADDITIVE MANUFACTURING: ENHANCING EXPEDITIONARY MANUFACTURING CAPABILITIES UP TO THE POINT OF-NEED FOR THE US ARMY

EXPERIMENTAL MEDIUM ENERGY PHYSICS

RESEARCH IN EXPERIMENTAL AND THEORETICAL HIGH ENERGY PHYSICS

HIGHER EDUCATION EMERGENCY RELIEF FUND – EMERGENCY FINANCIAL AID GRANTS FOR STUDENTS

CATEGORY II: UNLOCKING INTERACTIVE AI DEVELOPMENT FOR RAPIDLY EVOLVING RESEARCH

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

TRACK 1: ACCESS RESOURCE ALLOCATIONS MARKETPLACE AND PLATFORM SERVICES (RAMPS) -THE CARNEGIE-MELLON UNIVERSITY TEAM PROVIDES ALLOCATION SERVICES AS PART OF THE ADVANCED CYBERINFRASTRUCTURE COORDINATION ECOSYSTEM: SERVICES & SUPPORT (ACCESS) PROGRAM. THE RESOURCE ALLOCATIONS MARKETPLACE AND PLATFORM SERVICES (RAMPS) PROJECT IS TRANSFORMING THE PROCESS OF ALLOCATION FOR THE EVER-EVOLVING RANGE OF NSF-FUNDED RESOURCES IN THE ACCESS ECOSYSTEM. THIS ECOSYSTEM INCLUDES MANY OF THE MOST POWERFUL COMPUTING, STORAGE, AND RELATED CYBERINFRASTRUCTURE RESOURCES AVAILABLE TO THE U.S. RESEARCH COMMUNITY. THESE RESOURCES PROVIDE ESSENTIAL CAPABILITIES FOR ADVANCING SCIENCE AND EDUCATION ACROSS ALL FIELDS OF SCIENCE. THE RAMPS ALLOCATION ENVIRONMENT OFFERS A WELCOMING GATEWAY THAT INSPIRES COLLABORATION AND PARTICIPATION IN THE PURSUIT OF SCIENTIFIC DISCOVERY WHILE CONTINUING TO PROVIDE AN ESSENTIAL GATEKEEPING FUNCTION WHEN NECESSARY TO BALANCE DEMAND FOR RESOURCES WITH THE AVAILABLE SUPPLY. THE RAMPS MARKETPLACE IS TOPPLING MANY CURRENT ALLOCATIONS APPROACHES BY REMOVING BARRIERS BETWEEN RESEARCHERS AND THEIR NEEDED RESOURCES, RAMPS CREATES AN OPEN, INVITING, AND DEMOCRATIZED MARKETPLACE. DIVERSITY, EQUITY, AND INCLUSION (DEI) IN THE ALLOCATIONS ENVIRONMENT IS A CENTRAL FOCUS OF THE PROJECT. RAMPS IS WORKING TO ENSURE THE FULL PARTICIPATION OF WOMEN, PERSONS WITH DISABILITIES, AND UNDERSERVED POPULATIONS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM). RAMPS PROVIDES AN EFFICIENT, SCALABLE AND SIMPLIFIED INTERFACE FOR RESEARCHERS, EDUCATORS, AND STUDENTS TO REQUEST RESOURCES IN SUPPORT OF THEIR RESEARCH, EDUCATIONAL, AND WORKFORCE DEVELOPMENT ENDEAVORS. THE RAMPS MODEL OF FOUR ALLOCATION TIERS, I.E., EXPLORE, DISCOVER, RAMP-UP, OR MAXIMIZE, GIVES RESEARCHERS WITH DIFFERENT NEEDS MULTIPLE ENTRY POINT OPTIONS WHICH OPTIMIZE TRADE-OFFS BETWEEN ALLOCATION APPLICATION PROCESS EFFICIENCY, REVIEW EFFORT, REVIEW TURNAROUND TIMES, AND AVAILABILITY OF RESOURCES. FOR THE RESOURCE PROVIDERS IN THE ECOSYSTEM, RAMPS STREAMLINES THE PROCESS OF INTEGRATING NEW SYSTEMS AND SERVICES. BUILT WITH AN EMPHASIS ON MODULARITY, EXTENSIBILITY, AND DECENTRALIZATION, THE RAMPS SOFTWARE PLATFORM IS FLEXIBLE ENOUGH TO ACCOMMODATE ALLOCATIONS FOR CURRENT AND FUTURE COMPUTATIONAL AND NON-COMPUTATIONAL RESOURCES AND SERVICES. ACCESS CREDITS, A UNIVERSAL ALLOCATION CURRENCY, AND STANDARDIZED ALLOCATION TIERS ALLOW RAMPS TO ACCELERATE ALLOCATION REQUESTS AND REVIEWS. FINALLY, THROUGH A SUITE OF INNOVATIVE PILOTS, RAMPS IS INTRODUCING DISRUPTIVE FEATURES TO THE ECOSYSTEM AND ALLOCATIONS MARKETPLACE TO: INFORM CURRENT AND FUTURE ENHANCEMENTS; DECENTRALIZE THE ENTRY POINTS FOR ACCESS ALLOCATIONS BY BUILDING A SET OF CAMPUS AND REGIONAL ON-RAMPS; INTEGRATE CLOUD RESOURCES; DEFINE COMPUTATIONAL WORKFLOWS AS ALLOCABLE RESOURCES; AND ENHANCE THE ALLOCATIONS INFRASTRUCTURE TO SERVE SENSOR NETS AND INSTRUMENTATION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

FLOURESCENT PROBES & IMAGING - NETWORKS & PATHWAYS(RMI)

STRI: AN INTEGRATED COMPUTATIONAL MODELING AND SIMULATION PLATFORM FOR QUALIFICATION AND CERTIFICATION OF ADDITIVE MANUFACTURING

AI INSTITUTE FOR SOCIETAL DECISION MAKING (AI-SDM) -DECISION MAKING IN DOMAINS SUCH AS A PUBLIC HEALTH CRISIS OR DISASTER RESPONSE HAS A SIGNIFICANT SOCIETAL AND ECONOMIC IMPACT. THESE DOMAINS PRESENT CRITICAL CHALLENGES FOR DECISION-MAKING AS THEY REQUIRE COMPLEX, POTENTIALLY LIFE-SAVING, DECISIONS TO BE MADE UNDER DYNAMIC, UNCERTAIN AND RESOURCE-CONSTRAINED SCENARIOS, WHILE ACCOUNTING FOR FACTORS THAT ARE KEY TO ACCEPTANCE OF THE DECISIONS, SUCH AS STAKEHOLDERS' BIASES AND PERCEPTION OF RISK, TRUST, AND EQUITY. AI ADVANCEMENTS AND DATA AVAILABILITY CAN COMPLEMENT HUMAN LIMITATIONS IN NAVIGATING THIS COMPLEX DECISION SPACE, HOWEVER, CURRENT SYSTEMS FAIL TO ACCOUNT FOR THE STAKEHOLDERS' MENTAL STATES AND BEHAVIOR. THE AI INSTITUTE FOR SOCIETAL DECISION MAKING (AI-SDM) WILL TARGET THIS OPPORTUNITY AT THE CONFLUENCE OF SOCIAL DECISION SCIENCES AND AI BY DEVELOPING HUMAN-CENTRIC AI FOR DECISION-MAKING AND INTER-DISCIPLINARY TRAINING, TO ENABLE TRANSFORMATIVE SOLUTIONS TO SOCIETAL DECISION CHALLENGES. BY BRINGING AI AND SOCIAL SCIENCE RESEARCHERS, AI-SDM WILL ENABLE EMERGENCY MANAGERS, PUBLIC HEALTH OFFICIALS, FIRST RESPONDERS, COMMUNITY WORKERS, AND THE PUBLIC TO MAKE QUICK, DATA-DRIVEN, AND RESOURCE-EFFICIENT DECISIONS, WHILE ALSO IMPROVING OUTCOMES BY ACCOUNTING FOR HUMAN FACTORS GOVERNING ACCEPTANCE. THE VISION OF AI-SDM WILL BE REALIZED VIA DEVELOPMENT OF NOVEL AI THEORY AND METHODS, TRANSLATIONAL RESEARCH, TRAINING, AND OUTREACH, ENABLED BY PARTNERSHIPS AMONG DIVERSE UNIVERSITIES, GOVERNMENT ORGANIZATIONS, CORPORATE PARTNERS, COMMUNITY COLLEGES, PUBLIC LIBRARIES, AND HIGH SCHOOLS. THE INSTITUTE WILL ESTABLISH THE ROLE OF AI IN ADVANCING AND BRIDGING HUMAN AND AUTONOMOUS DECISION-MAKING, UNDER THE USE-INSPIRED CHALLENGES OF WORKING IN ENVIRONMENTS THAT ARE DYNAMIC, UNCERTAIN, RESOURCE CONSTRAINED, AND REQUIRE SOCIETAL ACCEPTANCE ARISING IN PUBLIC HEALTH CRISIS AND DISASTER RESPONSE. SPECIFICALLY, THE FOUNDATIONAL RESEARCH WILL DEVELOP (1) COMPUTATIONAL REPRESENTATIONS OF HUMAN DECISION PROCESSES, (2) ROBUST AGGREGATION METHODS FOR COLLECTIVE DECISION-MAKING, (3) MULTI-OBJECTIVE AUTONOMOUS DECISION SUPPORT TOOLS, AND CORRESPONDING INNOVATIONS IN (4) CAUSAL AND COUNTERFACTUAL REASONING. THESE FOUNDATIONAL FOCI ARE INSPIRED BY, AND WILL BE APPLIED TO, EQUITABLE RESOURCE ALLOCATION TO IMPROVE PUBLIC HEALTH AND DISASTER OUTCOMES, TIMELY TARGETED INTERVENTIONS INFORMED BY HUMAN DECISION-MAKING TO ENCOURAGE ADHERENCE TO POLICY RECOMMENDATIONS, AND ADOPTION OF AI DECISION SUPPORT BY UNDERSTANDING HOW ADOPTION CAN BE MODULATED BY DIFFERENT USE PATTERNS. THE RESEARCH WILL BE GUIDED BY THEORETICAL ADVANCES IN COMPUTATIONAL COGNITIVE SCIENCE, SOCIAL-CHOICE THEORY, DISTRIBUTION-FREE STATISTICS, GAME THEORY, CASUAL AND COUNTERFACTUAL REASONING, AND INTERACTIVE AND AUTONOMOUS MACHINE LEARNING. IN ADDITION TO IMPACTING USE-CASE DOMAINS VIA A WIDE NETWORK OF PARTNERS, AI-SDM WILL DEVELOP THE NEXT GENERATION OF WORKFORCE TRAINED ON HUMAN-CENTRIC AI AND AN AI-AWARE PUBLIC VIA BROADER IMPACT EFFORTS INCLUDING PROFESSIONAL DEVELOPMENT WORKSHOPS FOR HIGH SCHOOL EDUCATORS, ENRICHMENT AND LEADERSHIP ACTIVITIES FOR UNDER-REPRESENTED STUDENTS, INTER-DISCIPLINARY DEGREES AND COURSES, CURRICULUM CO-DESIGN WITH COMMUNITY COLLEGE AND EDUCATIONAL PARTNERS, WORKFORCE TRAINING, AND PUBLIC ENGAGEMENT ACTIVITIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

UNIVERSITY TRANSPORTATION CENTERS

THE DELPHI CENTER FOR OUTBREAK ANALYTICS AND DISEASE MODELING IN PUBLIC HEALTH RESPONSE: INNOVATION AND COORDINATION

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

MULTISCALE ANALYSES OF 4D NUCLEOME STRUCTURE AND FUNCTION BY COMPREHENSIVE MULTIMODAL DATA INTEGRATION

A CONFOCAL FLUORESCENCE MICROSCOPY BRAIN DATA ARCHIVE

GRADUATE RESEARCH FELLOWSHIP PROGRAM

CATEGORY I: BRIDGES-3: INTEGRATING AI, DATA & HPC TO ADVANCE AMERICAN SCIENTIFIC LEADERSHIP -BRIDGES-3 IS THE CONTINUATION OF PSC?S LONG STANDING ROLE IN PROVIDING PRODUCTION QUALITY NATIONAL CYBERINFRASTRUCTURE THROUGH THE NSF ADVANCED COMPUTING SYSTEMS & SERVICES (ACSS) PROGRAM. AS THE SUCCESSOR TO BRIDGES 2, BRIDGES-3 CARRIES FORWARD THE PROGRAM?S CORE OBJECTIVE OF DELIVERING SYSTEMS AND SERVICES THAT ADAPT TO RAPID EVOLUTION IN COMPUTING AND DATA TECHNOLOGIES WHILE REMAINING RELIABLE, ACCESSIBLE, AND BROADLY USABLE BY THE U.S. RESEARCH COMMUNITY. BRIDGES-3 OFFERS A BALANCED, CONVERGED ENVIRONMENT THAT INTEGRATES ADVANCED GPU ACCELERATED COMPUTING, HIGH PERFORMANCE, LARGE-MEMORY CPUS, A HARDENED ALL FLASH PARALLEL FILE SYSTEM, AND A HIGH BANDWIDTH INFINIBAND FABRIC, PROVIDING A COHESIVE, SCALABLE PLATFORM FOR SIMULATION, ARTIFICIAL INTELLIGENCE, DATA ANALYTICS, AND COMPLEX HIGH-PERFORMANCE COMPUTING WORKFLOWS. THE OVERALL ARCHITECTURE IS INFORMED BY SCIENCE DRIVERS DRAWN FROM THE CRITICAL SCIENTIFIC DOMAINS LISTED IN MEMORANDUM M-25-34/NSTM-2 FROM THE OFFICE OF SCIENCE AND TECHNOLOGY POLICY, WHICH OUTLINES PRIORITIES FOR NATIONAL INVESTMENT AND ACTIONS IN FISCAL YEAR 2027, INCLUDING ARTIFICIAL INTELLIGENCE, QUANTUM INFORMATION SCIENCE, MATERIALS AND MICROELECTRONICS, BIOMEDICAL RESEARCH, ADVANCED MANUFACTURING, AND ENERGY SYSTEMS. BRIDGES-3 WILL CONTINUE TO INTEGRATE WITH SCIENCE GATEWAYS, CLASSROOM INSTRUCTION, AND COMMUNITY OUTREACH PROGRAMS TO ENSURE THAT ADVANCED COMPUTING REMAINS ACCESSIBLE AND USEFUL ACROSS COMMUNITIES. THESE EFFORTS ALIGN WITH NATIONAL GOALS OF SUPPORTING GOLD-STANDARD SCIENCE, BUILDING THE SCIENCE AND TECHNOLOGY (S&T) WORKFORCE OF THE FUTURE, EXPANDING WORLD-CLASS RESEARCH INFRASTRUCTURE, AND STRENGTHENING AMERICA?S S&T ECOSYSTEM. COMBINED WITH SEAMLESS INTEROPERABILITY WITH NATIONAL PLATFORMS AND RESOURCES SUCH AS THE ADVANCED CYBERINFRASTRUCTURE COORDINATION ECOSYSTEM: SERVICES & SUPPORT (ACCESS) CAPABILITY, THE NATIONAL AI RESEARCH RESOURCE (NAIRR), AND THE LEADERSHIP-CLASS COMPUTING FACILITY (LCCF), THESE ELEMENTS ENSURE THAT BRIDGES-3 WILL PROVIDE STABLE AND PRODUCTIVE SERVICE TO THE U.S. RESEARCH COMMUNITY WHILE SUPPORTING THE BROAD GOALS OF THE NSF STRATEGIC PLAN. -- THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

THIS PROPOSED PROJECT, TITLED CACES, AIMS TO CREATE A RESEARCH CENTER THAT UTILIZES NOVEL MEASUREMENT AND MODELING APPROACHES TO UNDERSTAND SPATIAL A

HIGH ENERGY PHYSICS & SSC CALORIMETER SUB SYSTEM R&D

SLC CENTER: PITTSBURGH SCIENCE OF LEARNING CENTER: STUDYING ROBUST LEARNING WITH LEARNING EXPERIMENTS IN REAL CLASSROOMS

CIF21 DIBBS: THE DATA EXACELL

NAME OF EFFORT: CHRONOS: CHRONOLOGICAL AND HIERARCHICAL REASONING OVER NEWLY OBSERVED SCHEMAS TYPE OF AWARD: COOPERATIVE AGREEMENT THE RECIPIENT

PATIENT CARE TECHNOLOGIES FOR PERMANENT AMBULATORY ARTIFICIAL LUNG SUPPORT

TAS::97 0400::TAS OPERATIONS-ORIENTED PROBABLE EXTRACTION, REASONING, AND ANALYSIS (OPERA)

UNIVERSITY TRANSPORTATION CENTER

TAS::97 0400::TAS INTELLIGENT MODEL-BASED ADAPTATION FOR MOBILE ROBOTICS

TAS::57 3600::TAS "HOMOTOPY TYPE THEORY: UNIFIED FOUNDATIONS OF MATHEMATICS AND COMPUTATION,"

RICH REPRESENTATIONS WITH EXPOSED SEMANTICS FOR DEEP VISUAL REASONING

SUCCESS: SELF-ASSESSMENT AND UNDERSTANDING OF COMPETENCE AND CONDITIONS TO ENSURE SYSTEM SUCCESS

TEEN PREGNANCY PREVENTION REPLICATION OF UPDATED INTERACTIVE VIDEO INTERVENTION

TAS::57 3600::TAS "(MURI 09) MANAGING THE MOSAIC OF MICROSTRUCTURE" (THE GRANTEE'S TECHNICAL PROPOSAL DATED 10 NOV 2011)

"(MURI-08) MODELING SYNERGIES IN LARGE HUMAN-MACHINE NETWORKED SYSTEMS"

EXPERIMENTAL MEDIUM ENERGY PHYSICS

STRUCTURED DISTRIBUTED SEMANTICS: ANALYSIS AND FILTERING OF TEXT

DECENTRALIZED REASONING IN REDUCED INFORMATION SPACES

CPS: FRONTIER: SOFTWARE-DEFINED NANOSATELLITE CONSTELLATIONS: THE FOUNDATION OF FUTURE SPACE-BASED CYBER-PHYSICAL SYSTEMS -THE REACH OF CYBER-PHYSICAL SYSTEMS INTO SPACE IS GROWING EXPONENTIALLY, AS LAUNCH SERVICES PROLIFERATE AND SATELLITES HAVE BECOME SMALL, CHEAP, AND CAPABLE. UNLIKE EXPENSIVE SATELLITES OF THE PAST, THE NEAR FUTURE PROMISES CONSTELLATIONS OF THOUSANDS OF INEXPENSIVE NANOSATELLITES. NANOSATELLITES ARE BECOMING CAPABLE OF SUPPORTING SPACE-BASED CYBER-PHYSICAL APPLICATIONS, INCLUDING DEFENSE, SMART CITIES, AGRICULTURE, & INFRASTRUCTURE, CLIMATE SCIENCE, AND SEARCH & RESCUE. UNFORTUNATELY, NANOSATELLITES TODAY OPERATE LIKE MONOLITHIC SATELLITES OF THE PAST, MANUALLY OPERATED AT HIGH COST, IMPEDING THE REALIZATION OF THE POTENTIAL OF NANOSATELLITES FOR THESE IMPORTANT CYBER-PHYSICAL SYSTEMS APPLICATIONS. THIS PROJECT ENVISIONS A NEW OPERATING MODEL FOR SPACE-BASED CYBER-PHYSICAL SYSTEMS IN NANOSATELLITE CONSTELLATIONS CALLED A SOFTWARE-DEFINED NANOSATELLITE CONSTELLATION, WHICH UNLEASHES THEIR POTENTIAL. A SOFTWARE-DEFINED CONSTELLATION IS A COLLECTION OF NANOSATELLITES CAPABLE OF AUTONOMOUSLY SENSING THE ENVIRONMENT, PROCESSING DATA, AND COOPERATIVELY PLANNING AND TAKING MECHANICAL ACTIONS. THE PROJECT REALIZES THIS VISION THROUGH CROSS-CUTTING CYBER-PHYSICAL SYSTEMS RESEARCH SPANNING COMPUTER SYSTEMS, CONTROL, PLANNING, ACTUATION, MACHINE LEARNING, AND COMMUNICATIONS. THIS PROJECT WILL CULMINATE IN THE LAUNCH OF A SOFTWARE-DEFINED CONSTELLATION TESTBED THAT IMPLEMENTS SEVERAL SPACE-BASED APPLICATIONS, DEMONSTRATING THESE SOCIETALLY IMPORTANT CAPABILITIES AND APPLICATIONS, AND FUNCTIONING AS A VALUABLE RESOURCE FOR OTHER CYBER-PHYSICAL SYSTEMS RESEARCHERS. THIS CPS FRONTIER PROJECT IS ESTABLISHING NANOSATELLITE CONSTELLATIONS AS SOPHISTICATED, MULTI-TENANT PLATFORMS FOR SPACE-BASED CYBER-PHYSICAL SYSTEMS APPLICATIONS. THE WORK IS INTERDISCIPLINARY, SPANNING CONTROLS, ML, COMMUNICATIONS, SYSTEMS, AND HARDWARE. THE PROJECT MAKES CONSTELLATIONS AUTONOMOUS AND EQUIPPED TO COMPUTE EFFICIENTLY ON ORBIT. ON-ORBIT COMPUTING TREATS CONSTELLATION-LEVEL SATELLITE CONTROL AND ACTUATION AS RESOURCE MANAGEMENT FOR UNIQUE NANOSATELLITE RESOURCES: SENSOR DATA, BANDWIDTH, ENERGY, AND COMPUTING. ON-ORBIT MACHINE LEARNING TECHNIQUES BRING FEDERATED LEARNING TO THE CONSTELLATION, CREATING AN AUTONOMOUS ORBITAL LEARNING SYSTEM. THE PROJECT?S NEW COMMUNICATION TECHNIQUES EXTRACT MAXIMUM INFORMATION FROM EACH BIT COMMUNICATED, COMBINING WEAK SIGNALS AND OFTEN AVOIDING COMMUNICATION ALTOGETHER. THE PROJECT DEMONSTRATES THE PROJECT?S VALUE WITH ON-ORBIT INFRASTRUCTURE AND TESTBEDS THAT FORM AN OPEN PLATFORM FOR FUTURE SPACE-BASED CYBER-PHYSICAL SYSTEMS RESEARCH. THE PROJECT WILL HAVE A BROAD, TRANSFORMATIVE IMPACT ON SOCIETY, INDUSTRY, AND EDUCATION, WITHIN AND BEYOND THE CYBER-PHYSICAL AND SPACE SYSTEMS COMMUNITIES. SOFTWARE-DEFINED NANOSATELLITE CONSTELLATIONS CREATE AN INDUSTRY OF COST-EFFECTIVE SPACE-BASED APPLICATIONS. THE PROJECT ELIMINATES BARRIERS TO SPACE, ENABLING INDUSTRY TO DEVELOP SPACE-BASED APPLICATIONS. THE PROJECT CREATES A NEW FIELD OF RESEARCH AROUND SPACE-BASED CYBER-PHYSICAL SYSTEMS FOSTERING RESEARCH AND EDUCATION. THIS PROJECT INCLUDES AMBITIOUS EDUCATION ACTIVITIES FROM MIDDLE SCHOOL TO POST-GRADUATE LEVELS. THE PROJECT TEAM WILL MENTOR MIDDLE SCHOOLERS AND HIGH SCHOOLERS FROM URBAN PUBLIC SCHOOLS THROUGH SPACE SYSTEMS RESEARCH INTERNSHIPS. THE PROJECT TEAM WILL INVOLVE UNDERGRADUATES AND GRADUATE STUDENTS IN RESEARCH MENTORING AND NEW CURRICULA. THE PROPOSED OUTREACH ACTIVITIES WILL ENGAGE SOCIETY BROADLY VIA ARTIST-IN-RESIDENCE PROGRAMS, RESEARCH COMMUNITY-BUILDING, AND PUBLIC/ACADEMIC/PRIVATE PARTNERSHIPS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

UNIVERSITY TRANSPORTATION CENTER

A HYBRID COMPUTER PLATFORM TO DESIGN, GUIDE, AND PARTNER WITH HUMANS IN THE TEAM PROBLEM-SOLVING PROCESS.

THE LINGUISTIC-CORE APPROACH TO STRUCTURED TRANSLATION AND ANALYSIS OF LOW-RESOURCE LANGUAGES

APHASIABANK: A SHARED DATABASE FOR THE STUDY OF APHASIC COMMUNICATION

HIGH PERFORMANCE COMPUTING FOR BIOMEDICAL RESEARCH

TAS::97 0400::TAS HIGH ASSURANCE SPIRAL: SCALABLE AND PERFORMANCE PROTABLE DOMAIN-SPECIFIC CONTROL SYSTEMS SYNTHESIS

DMUU: CENTER ON CLIMATE DECISION MAKING

FLUORESCENT BIOSENSORS FOR NETWORKS AND PATHWAYS

MODELING CULTURAL FACTORS IN COLLABORATION AND NEGOTIATION

FIA: COLLABORATIVE RESEARCH: A CONTENT AND SERVICE FRIENDLY ARCHITECTURE WITH INTRINSIC SECURITY AND EXPLICIT TRUST

YEAST RIBOSOME BIOGENESIS

A STRUCTURAL APPROACH TO THE INCORPORATION OF CULTURAL KNOWLEDGE IN ADAPTIVE ADVERSARY MODELS

ANALYSIS OF NONSTATIONARY POINT PROCESS DATA

COMPREHENSIVE AUTOMATION FOR SPECIALTY CROPS

COMPREHENSIVE AUTOMATION FOR SPECIALTY CROPS

COMPREHENSIVE AUTOMATION FOR SPECIALTY CROPS

TITLE: CMU/NIST AI MEASUREMENT SCIENCE & ENGINEERING COOPERATIVE RESEARCH CENTERPURPOSE: ESTABLISH THE CMU/NIST AI MEASUREMENT SCIENCE & ENGINEERING COOPERATIVE RESEARCH CENTER (AIMSEC) TO FACILITATE COLLABORATIVE RESEARCH AND EXPERIMENTATION FOCUSED ON ADVANCING OUR NATIONAL CAPABILITY FOR TEST AND EVALUATION OF MODERN AI CAPABILITIES AND TOOLS. THERE ARE THREE PRINCIPAL GOALS: 1. ADVANCE MODERN AI RISK MANAGEMENT 2. VALIDATE EVALUATION APPROACHES THROUGH STAKEHOLDER PARTNERSHIPS. 3. TRANSLATE ASSESSMENT CAPABILITIES AND METHODOLOGIES TO PRACTICE. RESEARCH WILL FOCUS ON ADVANCING MEASUREMENT SCIENCE FOR MODERN AI SYSTEMS, INCLUDING MACHINE LEARNING (ML) AND GENERATIVE AI (GENAI) SYSTEMS, SUCH AS LARGE LANGUAGE MODELS (LLMS). ACTIVITIES TO BE PERFORMED: CREATE A PRACTICAL TAXONOMY OF THREATS AGAINST LARGE LANGUAGE MODELS (LLMS). THE PROPOSED WORK INCLUDES DEVELOPING TECHNIQUES TO REDUCE MEMORIZATION AND PROTECT CONFIDENTIAL INFORMATION PROVABLY, EVEN IF IT RESULTS IN LESS EXACT OUTPUTS. DEVELOP NEW MEASURES OF ROBUSTNESS FOR ML MODELS THAT BETTER REFLECT A MODEL?S ABILITY TO WITHSTAND ATTACKS IN PRACTICAL SCENARIOS. DEVELOP RICHER DEFINITIONS OF ALIGNMENT, CORRECTNESS, AND INTENT TO DETERMINE THE SUITABILITY OF GENERATIVE AI SYSTEMS FOR THEIR INTENDED USES. CREATE A STATE-OF-THE-ART SUITE OF ATTACKS AGAINST LLMS FOR TESTING NEW MODELS. THESE ACTIVITIES WILL BE ORGANIZED IN THREE STREAMS OF EFFORT ALIGNED WITH NIST AI PRIORITIES. - VALIDITY, RELIABILITY, SAFETY, PRIVACY, AND SECURITY- ACCOUNTABILITY, TRANSPARENCY, FAIRNESS, AND EXPLAINABILITY- GENERATIVE AI EVALUATIONEXPECTED OUTCOMES: DEVELOPMENT OF AI SYSTEM-LEVEL TOOLING, METRICS, EVALUATION PROCEDURES, DEVELOPMENT PROCESSES, AND BEST PRACTICES TO ENSURE AI SYSTEM BUILDERS CONSISTENTLY ENGINEER SAFE AI SYSTEMS. GOALS ARE TO ADVANCE MODERN AI RISK MANAGEMENT, VALIDATE EVALUATION APPROACHES THROUGH STAKEHOLDER PARTNERSHIPS, AND TRANSLATE ASSESSMENT CAPABILITIES AND METHODOLOGIES TO PRACTICE. RESEARCH WILL FOCUS ON ADVANCING MEASUREMENT SCIENCE FOR MODERN AI SYSTEMS, INCLUDING MACHINE LEARNING (ML) AND GENERATIVE AI (GENAI) SYSTEMS, SUCH AS LARGE LANGUAGE MODELS (LLMS). THESE EFFORTS ARE EXPECTED TO YIELD ADDITIONAL APPROACHES TO MITIGATION OF WEAKNESSES AND VULNERABILITIES, PRIVACY PROTECTION, A PRACTICAL TAXONOMY OF THREATS AGAINST LLMS, APPROACHES TO MEET AI GOVERNANCE CHALLENGES, AND NEW SOCIO-TECHNICAL DEFINITIONS AND METRICS.INTENDED BENEFICIARIES: AI STAKEHOLDERS, INCLUDING GOVERNMENT, INDUSTRY, ACADEMIA, AND THE GENERAL PUBLIC, WILL BENEFIT FROM THIS WORK OF ADVANCING CAPABILITY FOR TESTING AND EVALUATING MODERN AI CAPABILITIES AND TOOLS.SUBRECIPIENT ACTIVITIES: THERE ARE NO PLANNED SUBAWARDS.

DEVELOPMENT OF AN ECOSYSTEM FOR QUALIFICATION OF ADDITIVE MANUFACTURING PROCESSES AND MATERIALS IN AVIATION ..THIS PROJECT WILL ADDRESS BOTH OUTCOMES FOR TOPIC 7 (AVIATION MANUFACTURING) NAMELY: .MANUFACTURING METHODS THAT REDUCE COSTS AND INCREASE THE SPEED OF AIRCRAFT MANUFACTURE WHILE MAINTAINING OR IMPROVING PRODUCT QUALITY AND RELIABILITY; .PRODUCING PRODUCTS WITH THE FLEXIBILITY OF CUSTOM MANUFACTURING AND THE COST OF MASS PRODUCTION IN ORDER TO QUICKLY RESPOND TO DIFFERENT CUSTOMER DEMANDS. ..WE IDENTIFY ADDITIVE MANUFACTURING (AM) AS THE MOST PROMISING NEW TECHNOLOGY FOR ACHIEVING THE TWO OUTCOMES ABOVE BECAUSE OF ITS FLEXIBILITY IN DESIGN AND CUSTOMIZATION AS WELL AS SPEED IN DELIVERING FINISHED PARTS FOR USE. THE MAJOR CHALLENGES ASSOCIATED WITH AM ARE AN ABILITY TO QUALIFY PARTS AND THE COSTS ASSOCIATED WITH THE TECHNOLOGY. OUR TEAM WILL ACCORDINGLY STUDY AND MATURE TECHNOLOGIES TO SPEED QUALIFICATION OF AM COMPONENTS AND THEIR SUBSEQUENT PRODUCTION THROUGH STUDIES CARRIED OUT IN OUR RESEARCH LABORATORIES AND IN A PILOT PRODUCTION FACILITY BEING CONSTRUCTED IN THE HAZELWOOD NEIGHBORHOOD OF PITTSBURGH NEAR THE CARNEGIE MELLON CAMPUS. ..ADDITIVE MANUFACTURING OFFERS UNIQUE OPPORTUNITIES FOR THE AVIATION INDUSTRY IN THE FABRICATION OF ORIGINAL COMPONENTS AND REPLACEMENT PARTS. A PARALLEL CAN BE MADE WITH WHAT SPACEX HAS BEEN ABLE TO ACHIEVE IN THE MANUFACTURE OF SPACE LAUNCH VEHICLES. ..AGGRESSIVE USE OF METALS AM HAS ALLOWED THE RAPID DEVELOPMENT AND PRODUCTION OF NEW LAUNCH VEHICLE DESIGNS AT SUBSTANTIALLY REDUCED COSTS. AVIATION HAS UNIQUE CHALLENGES SUCH AS HIGHER PRODUCTION VOLUMES BUT THE POTENTIAL VALUE OF INTEGRATING AM INTO AVIATION MANUFACTURING IS CLEAR. ..TWO BARRIERS NEED TO BE OVERCOME TO ACHIEVE THIS GOAL. THEY ARE 1) THE LACK OF AN APPLIED SCIENTIFIC BASIS FOR RAPID QUALIFICATION OF AM-PRODUCED PARTS AND 2) THE LACK OF FACILITIES DEMONSTRATING THE EFFICIENT PRODUCTION OF LARGE QUANTITIES OF COMPONENTS BY AM. QUALIFICATION OF AM COMPONENTS IS A NECESSARY STEP TOWARDS MANUFACTURING METHODS THAT INCREASE THE SPEED OF AIRCRAFT MANUFACTURE BY DRASTICALLY SHORTENING THE DESIGN-PROTOTYPE-REFINE-PRODUCE CYCLE. MAKING QUALIFIED AM COMPONENTS WIDELY AVAILABLE ALSO ENHANCES FLEXIBILITY IN THAT AM IS INHERENTLY CUSTOM AND ABLE TO RESPOND TO EVOLVING CUSTOMER DEMANDS. EFFICIENT PRODUCTION OF AM COMPONENTS REQUIRES THE PLANNING AND EXECUTION OF PILOT MANUFACTURING STUDIES COMBINING AM (AND PERHAPS NEW AM PRODUCTION PLATFORMS) AUTOMATION COMBINED HUMAN AND ROBOTIC PREPROCESSING AND POST PROCESSING OPERATIONS MONITORING INSPECTION AND OTHER OPERATIONS. THROUGH OUR COLLABORATIONS WE HAVE SEEN MANY COMPANIES (NOT CONFINED TO AERONAUTICS) THAT ARE SUCCESSFUL IN USING AM FOR PROTOTYPING AND TOOLING FABRICATION BUT ARE UNABLE TO MAKE THE TRANSITION TO RAPID QUALIFICATION AND EFFICIENT PRODUCTION. THE OVERARCHING RESEARCH OBJECTIVE FOR THIS PROJECT IS TO USE ENGINEERING PHYSICS LEARNED TO DATE TO ESTABLISH PROCESSING AND POST-PROCESSING DESIGN PROTOCOLS THAT DEFINE A PATH TO QUALIFICATION OF ADDITIVELY MANUFACTURED PARTS AND THEN TO APPLY THEM IN A PILOT PRODUCTION ENVIRONMENT. ..EXPECTED RESEARCH PRODUCTS INCLUDE REPORTS TO NASA PEER-REVIEWED ARTICLES PATENTS PRESENTATIONS CONFERENCES PRESENTATIONS WORKSHOPS AND SEMINARS AT RELEVANT NASA LOCATIONS. ..OUR TEAM OFFERS MULTIPLE AVENUES FOR TRANSITION. THE INDUSTRY CONSORTIA RUN BY SEVERAL ACADEMIC TEAM MEMBERS PROVIDE A NATURAL VEHICLE FOR COMMUNICATING THE RESULTS OF OUR RESEARCH AND SEEKING PARTNERS FOR DEPLOYMENT. LARGER EFFORTS TO DEVELOP DIGITAL TWINS FOR AIRCRAFT WILL PROVIDE AN ENTRY POINT FOR THE METHODOLOGIES. ESTABLISHING COLLABORATIONS WITH NASA SITES INVOLVED IN AM SUCH AS MARSHALL JPL LANGLEY AND GLENN PROVIDES A COMPLEMENTARY AVENUE FOR TRANSITION. CERTAIN TECHNICAL DEVELOPMENTS ARE AMENABLE TO COMMERCIALIZATION WHICH CAN OCCUR VIA LICENSING OR VIA STARTUP COMPANIES. .

SCHOLARSHIP FOR SERVICE @ CARNEGIE MELLON

SWITCH TRIAL: EARLY FEASIBILITY STUDY OF STENTRODE BCI FOR AUGMENTATIVE COMMUNICATION - 7. PROJECT SUMMARY MULTIPLE EARLY FEASIBILITY TRIALS IN HUMANS HAVE DEMONSTRATED THAT IMPLANTABLE BRAIN-COMPUTER INTERFACES (BCIS) CAN ENABLE PEOPLE WITH SEVERE PARALYSIS TO USE NEURAL SIGNALS TO CONTROL REMOTE AND DIGITAL COMMUNICATION TECHNOLOGIES, INCLUDING MESSAGING AND EMAIL. SUCH STUDIES HAVE DEMONSTRATED CLEARLY THAT BCIS HAVE THE POTENTIAL TO IMPROVE THE QUALITY OF LIFE OF PATIENTS WHO HAVE PHYSICAL DISABILITY DUE TO PARALYSIS OF SPEECH AND UPPER LIMBS. HOWEVER, UNTIL THESE TECHNOLOGIES ARE COMMERCIALIZED, ACCESS TO BCIS WILL REMAIN LIMITED TO PEOPLE INVOLVED IN RESEARCH STUDIES, AND ONLY FOR THE DURATION OF THEIR ENROLMENT IN THE STUDY. TO ADDRESS THIS UNMET NEED, SYNCHRON, INC. HAS DEVELOPED THE STENTRODETM SYSTEM, A FULLY IMPLANTABLE BCI THAT COMMUNICATES WIRELESSLY TO AN EXTERNAL INTERFACE ON A MOBILE COMPUTING PLATFORM. THE STENTRODETM BCI IS A 16-CHANNEL ARRAY OF SENSORS INTEGRATED INTO A SELF-EXPANDING, STENT-LIKE SUBSTRATE. THE STENTRODETM IS DELIVERED ENDOVASCULARLY VIA A CATHETER TO THE SUPERIOR SAGITTAL SINUS, WHERE IT MEASURES VOLITIONALLY-MODULATED NEURAL SIGNALS FROM THE LEG AREA OF MOTOR CORTEX IN BOTH HEMISPHERES. A FULLY IMPLANTABLE, WIRELESS TELEMETRY UNIT DIGITIZES AND TRANSMITS THE NEURAL SIGNALS FROM THE STENTRODETM TO AN EXTERNAL MOBILE PROCESSOR THAT CONVERTS THE NEURAL SIGNALS INTO COMMANDS FOR OPERATING A COMPUTER OR OTHER ASSISTIVE DEVICE, SUCH AS A SPELLER FOR COMMUNICATION. THE SYNCHRON TEAM HAS ALREADY INITIATED A FIRST-IN-HUMAN TRIAL OF THE STENTRODETM BCI SYSTEM IN MELBOURNE, AUSTRALIA, UNDER APPROVALS GRANTED BY THE THERAPEUTIC GOODS ADMINISTRATION (TGA) OF AUSTRALIA AND THE IRB OF THE ROYAL MELBOURNE HOSPITAL. THE FIRST HUMAN IMPLANT WAS PERFORMED IN A PERSON WITH AMYOTROPHIC LATERAL SCLEROSIS (ALS) IN AUGUST, 2019. THE PARTICIPANT HAS EXPERIENCED NO ADVERSE EVENTS AND IS USING THE SYSTEM TO OPERATE A COMPUTER AND TYPE MESSAGES TO FRIENDS, FAMILY, AND CAREGIVERS. THE OBJECTIVE OF THE PROPOSED RESEARCH IS TO DEMONSTRATE IN AN EARLY FEASIBILITY STUDY (EFS) THAT THE STENTRODETM BCI COMMUNICATION SYSTEM IS SAFE AND EFFECTIVE IN PROVIDING A QUANTIFIABLE IMPROVEMENT IN INDEPENDENCE AND QUALITY OF LIFE IN N=6 PEOPLE WITH SEVERE PARALYSIS DUE TO ALS. TWO SPECIFIC AIMS ARE PROPOSED: 1) PRECLINICAL ASSESSMENT OF THE STENTRODETM FOR SAFETY AND FUNCTIONALITY TO COMPLETE AN FDA SUBMISSION, AND 2) TESTING OF STENTRODETM’S SAFETY AND EFFICACY IN AN EFS CLINICAL TRIAL IN TWO CENTERS OF EXCELLENCE IN THE USA. UNDER AIM 1 (UG3 PHASE), PRECLINICAL SAFETY STUDIES AND SOFTWARE VALIDATION IN LARGE ANIMAL STUDIES WILL BE COMPLETED TO TEST ROBUSTNESS OF STENTRODETM, COMPLIANCE TO SAFETY STANDARDS FOR CLASS III ELECTROMECHANICAL IMPLANTS, SAFETY AND BASELINE FUNCTIONALITY IN A LARGE ANIMAL MODEL, EFFICACY OF CUSTOM-BUILT SOFTWARE, AND A FUNCTIONAL NEUROIMAGING STUDY TO SUPPORT PRESURGICAL PLANNING. UNDER AIM 2 (UH3 PHASE), AN EFS STUDY WILL TEST SAFETY OF STENTRODETM PLACEMENT, MONITORING ADVERSE EVENTS, TARGET PATENCY, AND DEVICE MIGRATION. WHEN COMBINED WITH EYE-TRACKING TECHNOLOGY, USERS WILL BE TRAINED TO PERFORM COMPUTER-BASED TASKS USING EYE-GAZE TO CONTROL CURSOR POSITION AND BCI OUTPUTS TO CONTROL DISCRETE ACTIONS, SUCH AS LETTER OR MENU-ITEM SELECTION AND ZOOM. CLINICAL EFFICACY OUTCOMES WILL ASSESS THE RESTORATION OF INDEPENDENT FUNCTION BY USE OF PERSONAL DEVICES, INCLUDING TECHNICAL CAPABILITY (CLICK AND TYPING SPEED AND ACCURACY, SMART HOME, IOT, HAPTIC FEEDBACK), INDEPENDENT DOMESTIC FUNCTIONALITY (I-ADLS) AND QOL AND MENTAL WELLBEING (WHOQOL, MACGILL QOL, HADS).

A MULTIDISCIPLINARY NMR CENTER FOR BIOMEDICAL RESEARCH

CIF21 DIBBS: BUILDING A SCALABLE INFRASTRUCTURE FOR DATA-DRIVEN DISCOVERY AND INNOVATION IN EDUCATION

PERPETUALLY AVAILABLE AND SECURE INFORMATION SYSTEMS

TAS::97 0400::TAS PERSONALIZED PRIVACY ASSISTANTS FOR BIG DATA AND THE INTERNET OF THINGS

MRSEC: CARNEGIE MELLON UNIVERSITY MATERIALS RESEARCH SCIENCE AND ENGINEERING CENTER

RENEWAL: SCHOLARSHIP FOR SERVICE @ CARNEGIE MELLON

A SHARED DATABASE FOR THE STUDY OF PHONOLOGICAL DEVELOPMENT

COMPUTATIONAL ANALYSIS OF CHILD LANGUAGE TRANSCRIPT DATA

DATA-DRIVEN DISCOVERY OF OPTIMIZED MULTIFUNCTIONAL MATERIAL SYSTEMS CENTER OF EXCELLENCE

PIRE: SCIENCE AT THE TRIPLE POINT BETWEEN MATHEMATICS MECHANICS AND MATERIALS SCIENCE

TAS::57 3600::TAS 'CMU CENTER OF EXCELLENCE: TRUSTED HUMAN-MACHINE TEAMING'.

ANNOUNCEMENT OF AVAILABILITY OF FUNDS FOR RIGOROUS EVALUATION OF NEW OR INNOVATIVE APPROACHES TO PREVENT TEEN PREGNANCY (TIER 2B)

FIA-NP: COLLABORATIVE RESEARCH: DEPLOYMENT-DRIVEN EVALUATION AND EVOLUTION OF THE EXPRESSIVE INTERNET ARCHITECTURE

INSTITUTE FOR COMPUTER-AIDED REASONING IN MATHEMATICS -THE INSTITUTE FOR COMPUTER-AIDED REASONING IN MATHEMATICS (ICARM) IS A NATIONAL INSTITUTE DEDICATED TO CATALYZING FUNDAMENTAL ADVANCES IN MATHEMATICS BY HARNESSING THE ONGOING REVOLUTION IN AI AND COMPUTER-ASSISTED REASONING. ITS MISSION IS TO EMPOWER MATHEMATICIANS BY PROVIDING THEM WITH THE TOOLS AND EXPERTISE TO EFFECTIVELY INTEGRATE ARTIFICIAL INTELLIGENCE, MACHINE LEARNING, FORMAL METHODS, AND AUTOMATED REASONING INTO THEIR RESEARCH. MATHEMATICS IS INTEGRAL TO SCIENTIFIC AND TECHNOLOGICAL ACHIEVEMENT, UNDERPINNING ADVANCES ACROSS CRITICAL AREAS SUCH AS QUANTUM COMPUTING, CYBERSECURITY, DATA SCIENCE, COMPUTATIONAL MODELING, AND ENGINEERING. THE INSTITUTE SERVES AS A CRUCIAL RESOURCE FOR LEVERAGING RECENT BREAKTHROUGHS IN ARTIFICIAL INTELLIGENCE TO ACCELERATE PROGRESS IN MATHEMATICS. ICARM EMPHASIZES INTERDISCIPLINARY COLLABORATION AMONG MATHEMATICIANS, COMPUTER SCIENTISTS, AND STUDENTS. THE INSTITUTE HELPS TO TRAIN THE NEXT GENERATION OF RESEARCHERS IN COMPUTATIONAL METHODOLOGIES, PREPARING THEM FOR A BROAD RANGE OF SCIENTIFIC CAREERS, AND ACTIVELY EXPANDING THE RESEARCH COMMUNITY IN MATHEMATICS. ICARM PROVIDES SPECIALIZED TECHNICAL EXPERTISE TO SUPPORT MATHEMATICIANS IN ADOPTING AND UTILIZING ADVANCED TOOLS FOR COMPUTER-AIDED REASONING TO POWER MATHEMATICAL RESEARCH. THE INSTITUTE PROVIDES DIRECT SUPPORT FOR AUTOMATED REASONING, FORMAL VERIFICATION, MACHINE LEARNING, AND AI, SIGNIFICANTLY ENHANCING MATHEMATICAL RESEARCH CAPABILITIES. ICARM ORGANIZES TARGETED EVENTS, INCLUDING WORKSHOPS, COLLABORATIVE RESEARCH VISITS, AND INTENSIVE SUMMER TRAINING PROGRAMS, TO DISSEMINATE THESE SKILLS AND PROMOTE THE INTEGRATION OF THESE ADVANCED TECHNIQUES INTO MATHEMATICAL PRACTICE. THESE COLLECTIVE EFFORTS FOSTER NEW MATHEMATICAL INSIGHTS, STIMULATE INTERDISCIPLINARY COLLABORATION, AND ENSURE ROBUST, HANDS-ON SUPPORT FOR ADVANCING RESEARCH IN MATHEMATICS THROUGH CUTTING-EDGE MACHINE-DRIVEN REASONING. THIS AWARD BY THE DIVISION OF MATHEMATICAL SCIENCES IS ALSO SUPPORTED BY THE OFFICE OF ADVANCED CYBERINFRASTRUCTURE AND THE DIVISION OF COMPUTING AND COMMUNICATION FOUNDATIONS IN THE NSF DIRECTORATE FOR COMPUTER AND INFORMATION SCIENCE AND ENGINEERING AND THE OFFICE OF STRATEGIC INITIATIVES IN THE NSF DIRECTORATE FOR MATHEMATICAL AND PHYSICAL SCIENCES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

DELPHI INFLUENZA FORECASTING CENTER OF EXCELLENCE

REHABILITATION ENGINEERING RESEARCH CENTERS

21-000001204 NEUROBEHAVIORAL, PHYSIOLOGICAL, AND COMPUTATIONAL PROCESSES OF AUDITORY OBJECT LEARNING IN MAMMALS

POWER EFFICIENCY REVOLUTION FOR EMBEDDED COMPUTING TECHNOLOGIES (PERFECT) PROGRAM.

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH SUPPORTING THE DEFENSE ADVANCED RESEARCH PROJECTS AGENCY DARPA GUARANTEEING AI ROBUSTNESS AGAINST DECEPTION GARD PROGRAM. THE TERM OF THE BASE PERIOD FOR THIS AGREEMENT COMMENCES ON THE EFFECTIVE DATE OF THE AWARD AND CONTINUES THROUGH TWELVE 12 MONTHS THEREAFTER.

ACCESSIBLE MACHINE LEARNING

RERC ON PHYSICAL ACCESS AND TRANSPORTATION

FOSTERING INNOVATION THROUGH ROBOTICS EXPLORATION

DMUU: CLIMATE AND ENERGY DECISION MAKING

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH IN SUPPORT OF TTO IN THE AMOUNT OF 330,000 ON CONTRACT HR0011-18-2-0044.

COASTERCHASE PROGRAM - 24 MONTHS

SPACE EXPLORATION ACCESS TECHNOLOGIES RESEARCH PROGRAM: THIS PROJECT WILL CONDUCT INNOVATIVE RESEAR

POST-DOCTORAL RESEARCH FELLOWSHIPS

RESEARCH IN EXPERIMENTAL AND THEORETICAL HIGH ENERGY PHYSICS

COMPLIANT THORACIC ARTIFICIAL LUNGS

RERC ON PHYSICAL ACCESS AND TRANSPORTATION

STATIC ANALYSIS TO ENHANCE THE POWER OF MODEL CHECKING FOR CONCURRENT SOFTWARE

INFORMATION ASSURANCE SCHOLARSHIP PROGRAM

CONVERGENCE ACCELERATOR BIO-INSPIRED DESIGN INNOVATIONS: BIO-INSPIRED DESIGN OF ROBOTIC AND PROSTHETIC HANDS FOR USE-DRIVEN DEXTERITY -ROBOTIC HANDS WITH HUMAN-LIKE DEXTERITY ARE URGENTLY NEEDED TO ADDRESS MULTIPLE CHALLENGES FACING OUR NATION AND SOCIETY, INCLUDING ENHANCING PRODUCTIVITY IN MANUFACTURING AND IMPROVING QUALITY OF LIFE. ACCORDING TO DELOITTE, BY 2028 LABOR SHORTAGES COULD JEOPARDIZE MORE THAN $450 BILLION OF U.S. GDP IN THE MANUFACTURING SECTOR. MEANWHILE, OVER 400,000 AMERICANS LIVE WITH UPPER LIMB LOSS, AND MORE THAN 20 MILLION PEOPLE STRUGGLE WITH DAILY ACTIVITIES DUE TO LIMITED MOBILITY. WHILE AUTOMATION HAS THE POTENTIAL TO ALLEVIATE THESE PRESSURES, CURRENT ROBOTIC SOLUTIONS HAVE NOT BEEN EFFECTIVE. ROBOTIC HANDS HAVE YET TO GAIN WIDESPREAD ADOPTION IN FACTORIES, AND UPPER LIMB PROSTHETICS FACE THE HIGHEST RATES OF ABANDONMENT OF ANY ASSISTIVE DEVICE. TO ADDRESS THESE CHALLENGES, THIS PROJECT BRINGS TOGETHER A DIVERSE TEAM OF UNIVERSITY, INDUSTRY, AND GOVERNMENT PARTICIPANTS TO DEVELOP, PILOT, AND CREATE SUSTAINABLE PATHWAYS FOR ROBOTIC AND PROSTHETIC HANDS THAT ARE BIO-INSPIRED, FEATURE ALL-OVER SENSING AND INTELLIGENT CONTROL, AND ARE CUSTOMIZED TO THE NEEDS OF THE END-USER. THIS PROJECT HAS FOUR SPECIFIC GOALS FOR IMPACT: (A) EASE LABOR SHORTAGES IN A MANNER THAT BENEFITS BOTH MANUFACTURERS AND EMPLOYEES, (B) PREPARE NEW LEARNERS FOR A FUTURE OF WORK THAT INCLUDES DEXTEROUS ROBOTICS, (C) ENSURE THAT SMALL AND MEDIUM MANUFACTURERS HAVE ACCESS TO DEXTEROUS ROBOT HANDS FOR HIGH MIX / LOW VOLUME APPLICATIONS, AND (D) ENABLE INDIVIDUALS WITH DISABILITIES TO HAVE GREATER INDEPENDENCE TO MEET THEIR PERSONAL GOALS. RESEARCH THRUSTS TO ACHIEVE THESE GOALS EMPHASIZE (1) BIOINSPIRED SENSORS, SKELETON, AND SKIN DESIGNED FOR CUSTOMIZABILITY, RELIABILITY, AND MANUFACTURABILITY, (2) BIOINSPIRED FINE CONTROL WITH INTRINSIC MUSCLES FOR DEXTERITY IN A LIGHTWEIGHT AND COMPACT PACKAGE, AND (3) A SOFTWARE PIPELINE FOR CUSTOM ROBOT HAND DESIGN FOR BEST END-USER EXPERIENCE, PERFORMANCE, AND RELIABILITY. RESEARCH THRUSTS ARE ACCOMPANIED BY DEVELOPMENT EFFORTS, CUSTOMER OUTREACH, AND EDUCATIONAL ACTIVITIES TO ENSURE THAT IMPACT GOALS CAN BE MET WITH A SUSTAINABLE SOLUTION. A HAND THAT IS HUMANLIKE AND DEXTEROUS CAN ENABLE PEOPLE TO DO DANGEROUS WORK FROM A SAFE, REMOTE LOCATION OR TO PROVIDE EXPERT ASSISTANCE ANYWHERE IN THE WORLD. A ROBUST SOLUTION TO ROBOT DEXTERITY WILL SEE APPLICATION IN HOMES, WORKPLACES, FARMS, HELPING INDIVIDUALS TO AGE GRACEFULLY IN PLACE, SMALL BUSINESS OWNERS MANAGE LABOR SHORTAGES AND UPSCALE JOBS TO IMPROVE QUALITY OF LIFE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

A NATIONAL NETWORK FOR CRITICAL TECHNOLOGY ASSESSMENT: A PILOT -TITLE: A NATIONAL NETWORK FOR CRITICAL TECHNOLOGY ASSESSMENT: A PILOT ABSTRACT: THE NATIONAL NETWORK FOR CRITICAL TECHNOLOGY ASSESSMENT PILOT SEEKS TO LAY THE FOUNDATION FOR THE ABILITY TO ASSESS U.S. GLOBAL COMPETITIVENESS ON KEY EMERGING TECHNOLOGIES AND IDENTIFY WHERE AND HOW FEDERAL SCIENCE AND TECHNOLOGY INVESTMENTS CAN BE APPLIED TO ADVANCE U.S. COMPETITIVENESS AND THE WELL-BEING OF U.S. CITIZENS. USING DATA, ADVANCED ANALYTICS, AND EXPERT INSIGHTS, THE NATIONAL NETWORK PILOT EFFORT WILL IDENTIFY METHODS THAT COULD BE EMPLOYED TO DERIVE POLICY INSIGHTS AND DEVELOP AN UNDERSTANDING OF WHERE ADDITIONAL ANALYTICAL TOOLS AND DATA RESOURCES ARE NEEDED TO DRIVE COMPREHENSIVE ANALYSIS AND DECISION-MAKING. BRINGING TOGETHER A MULTIDISCIPLINARY GROUP OF EXPERTS, THE NATIONAL NETWORK WILL PAIR A TOP-DOWN APPROACH TO SCAN GLOBAL CAPABILITIES IN KNOWLEDGE, PRODUCTION, AND HUMAN CAPITAL WITH A BOTTOM-UP APPROACH TO DEVELOP AND DEMONSTRATE METHODS TO IDENTIFY OPPORTUNITIES FOR SCIENCE AND TECHNOLOGY INVESTMENT TO ADVANCE NATIONAL COMPETITIVENESS. THE BOTTOM-UP APPROACH WILL BE ACCOMPLISHED THROUGH DEEP DIVES IN FOUR KEY TECHNOLOGY AREAS: ARTIFICIAL INTELLIGENCE, BIOTECHNOLOGY, ENERGY STORAGE, AND SEMICONDUCTORS. THE OUTCOMES OF BOTH APPROACHES WILL BE SYNTHESIZED INTO A FINAL CRITICAL TECHNOLOGY ASSESSMENT REPORT. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

INTEGRATED AUTOMATION FOR SUSTAINABLE SPECIALTY CROP FARMING

INTEGRATED AUTOMATION FOR SUSTAINABLE SPECIALTY CROP FARMING

INTEGRATED AUTOMATION FOR SUSTAINABLE SPECIALTY CROP FARMING

(SURI) BREAKING THE 'LAUNCH ONCE, USE ONCE' PARADIGM

NEW; MOLECULAR-LEVEL DESIGN OF HETEROGENEOUS CHIRAL CATALYSTS; PI: ANDREW GELLMAN

ADOLESCENTS WITH AND WITHOUT DIABETES: TRANSITION TO EMERGING ADULTHOOD

INTERDISCIPLINARY TRAINING IN COMPUTATIONAL NEUROSCIENCE

VAN DER WAALS REPROGRAMMABLE QUANTUM SIMULATOR

"(CONGRESSIONAL) INTEGRATED NANOSENSOR SYSTEMS FOR A SAFER AMERICA

NEW START GRANT TO CARNEGIE MELLON UNIVERSITY

COLLABORATIVE RESEARCH: NEXT-GENERATION MODEL CHECKING AND ABSTRACT INTERPRETATION WITH A FOCUS ON EMBEDDED CONTROL AND SYSTEMS BIOLOGY

TAS:: 97 0400 ::TAS STATEMENT OF WORK ENTITLED "VELOCITY SENSOR ASSISTED MICRO INERTIAL MEASUREMENT (VSAMIM)".

COMPUTATIONAL METHODS TO INTEGRATE AND INTERPRET THE TRANSCRIPTOME FROM SINGLE CELL AND TISSUE LEVEL DATA

NEW START MURI CA "SSYMBIOTIC - SELF-SUSTAINING SENSORIZED MUSCLE-BASED BIOHYBRID TECHNOLOGIES WITH INTEGRATED CONTROL"

RESEARCH TRAINING PROGRAMS IN THE EDUCATION SCIENCES

BIOENGINEERING CORNEA WITH AUTOLOGOUS STEM CELLS

ELECTROPHYSIOLOGICAL SOURCE IMAGING OF PARTIAL EPILEPSY

ELECTROPHYSIOLOGY-COMPATIBLE WEARABLE TRANSCRANIAL FOCUSED ULTRASOUND NEUROMODULATION ARRAY PROBES - PROJECT SUMMARY NONINVASIVE HIGH PRECISION NEUROMODULATION TECHNOLOGIES ARE CRUCIAL FOR PROBING MECHANISMS OF NEURAL CIRCUITS AND ENABLING THE NON-PHARMACOLOGICAL TREATMENT OF BRAIN DISORDERS. TRANSCRANIAL-FOCUSED ULTRASOUND (TFUS) NEUROMODULATION HAS DEMONSTRATED ITS EFFICACY AND PRECISION IN MODULATING THE BRAIN, FROM NEURON TO CIRCUIT LEVEL. WE PROPOSE TO DEVELOP HIGHLY NOVEL TFUS NEUROMODULATION SYSTEMS ENABLING NONINVASIVE HIGH PRECISION TARGETING AND STIMULATION OF BRAIN CIRCUITS WITH HIGH FOCALITY AND DEEP BRAIN PENETRATION IN SMALL AND LARGE ANIMAL MODELS DURING AWAKE BEHAVING TASKS WITH SIMULTANEOUS NEURAL ACTIVITY MONITORING CAPABILITIES. WE WILL DEVELOP AND VALIDATE NOVEL WEARABLE ULTRASOUND NEUROMODULATION TRANSDUCER ARRAY (WUNTA) PROBES, COMPATIBLE WITH INTRACRANIAL ELECTROPHYSIOLOGICAL RECORDINGS, FOR PRECISE MODULATION AND RECORDING OF BRAIN ELECTRICAL ACTIVITIES IN BEHAVING ANIMAL MODELS. WE WILL USE EXISTING RODENT AND NON-HUMAN PRIMATE MODELS OF COMPLEX BEHAVIORS TO VALIDATE THE PERFORMANCE OF THE PROPOSED TFUS DEVICE THROUGH BEHAVIORAL ASSESSMENTS AND ELECTROPHYSIOLOGICAL RECORDINGS. THIS PROJECT HAS THREE SPECIFIC AIMS. AIM 1. DEVELOPING WEARABLE TFUS NEUROMODULATION ARRAY PROBES COMPATIBLE WITH ELECTROPHYSIOLOGICAL RECORDINGS AND BEHAVIOR ASSESSMENTS. WE WILL DEVELOP NOVEL 64-ELEMENT WUNTA PROBES FOR IN VIVO BEHAVING ANIMAL TESTING, WITH SIMULTANEOUS ELECTROPHYSIOLOGICAL RECORDING CAPABILITY. WE WILL DEVELOP THE PROPOSED NOVEL NEUROMODULATION PROBES, CONTROL SOFTWARE, AND OPTIMIZE THE TFUS PARAMETERS BASED ON A SERIES OF COMPUTER SIMULATIONS AND PHANTOM EXPERIMENTS. AIM 2. VALIDATING THE PERFORMANCE OF WEARABLE TFUS PROBE FOR SMALL ANIMALS THROUGH ELECTROPHYSIOLOGICAL RECORDINGS AT THE NUCLEUS ACCUMBENS IN AWAKE, BEHAVING RATS. FOLLOWING AN EFFECTIVE PARAMETER SEARCH ON AWAKE HEAD-FIXED RATS, WE WILL RIGOROUSLY EVALUATE THE PERFORMANCE OF A WEARABLE TFUS PROBE WITH ELECTROPHYSIOLOGICAL RECORDINGS, ON RATS THROUGH A REWARD-DRIVEN DISCRIMINATIVE STIMULUS BEHAVIOR TASK, WITH KNOWN NEURAL MECHANISMS INVOLVING THE NUCLEUS ACCUMBENS AND INPUTS FROM THE VENTRAL SUBICULUM. AIM 3. VALIDATING THE PERFORMANCE OF WEARABLE TFUS PROBE FOR LARGE ANIMALS AND OPTIMIZING STIMULATION PARAMETERS IN AN AWAKE, BEHAVING NON-HUMAN PRIMATE MODEL. WE WILL ASSESS THE PROPOSED PROBE IN A HEAD-FIXED, BEHAVING NON-HUMAN PRIMATE MODEL, VALIDATING THE PERFORMANCE METRICS OF THE WEARABLE TFUS PROBE FOR LARGE ANIMALS AND OPTIMIZING TFUS PARAMETERS TO ACHIEVE EFFECTIVE NEUROMODULATION. OVERALL, THE SUCCESSFUL DEVELOPMENT OF THE PROPOSED WEARABLE ULTRASOUND NEUROMODULATION TRANSDUCER ARRAY SYSTEM, INTEGRATED WITH ELECTROPHYSIOLOGICAL RECORDINGS IN AWAKE BEHAVING ANIMALS, PROMISES TO SIGNIFICANTLY ADVANCE OUR ABILITY TO INTERROGATE NEURAL CIRCUITS IN VARIOUS BEHAVING ANIMAL MODELS WITH A HIGH SPATIOTEMPORAL RESOLUTION AND HAS TREMENDOUS POTENTIAL FOR TRANSLATION TO CLINICAL UTILITY.

TAS::97 0400::TAS MACHINE LEARNING FOR ADAPTABLE HETEROGENEOUS INDEXING AND SEARCH

LINKS OF COMMUNAL COPING IN COUPLES WITH DIABETES TO SELF-CARE BEHAVIOR

MACHINE LEARNING ALGORITHMS FOR STATISTICAL PATTERNS IN LARGE DATA SETS

RETROFITTING SECURITY POLICY TO LATE-STAGE SOFTWARE--TAMING GIANTS THROUGH TYPES AND WIMPS

TWC SBE: OPTION: FRONTIER: COLLABORATIVE: TOWARDS EFFECTIVE WEB PRIVACY NOTICE AND CHOICE: A MULTI-DISCIPLINARY PROSPECTIVE

SPECIALIZATION OF NEURAL PROCESSING DURING ACTIVE ACOUSTIC SENSING IN MARINE MAMMALS AND HUMANS

TIP DIRECTED FIELD EMISSION NANOMANUFATURING

VETTING WHOLE COTS SYSTEMS FOR SAFETY AGAINST MALICIOUS FUNCTIONALITY

INTELLIGENT HW-SW COMPILERS FOR SIGNAL PROCESSING APPLICATIONS

NEW GRANT EFFORT TO SUPPORT 'STIRLING MICROCOOLER ARRAY WITH ELEMENTAL IN-PLANE FLOW

"NEW; MACHINE LEARNING FOR MASSIVE SCALE COSMOLOGY; PI - JEFF SCHNEIDER"

CORTICAL ORGANIZATION OF ACTION KNOWLEDGE BEFORE AND AFTER BRAIN SURGERY

COGNITIVELY COMPLIANT COMMAND FOR MULTIROBOT TEAMS

NEW MURI COOPERATIVE AGREEMENT "COMPLEXITY, NONLOCALITY, AND UNCERTAINTY IN HETEROGENEOUS SOLIDS"

IGERT: EDUCATING AND THE INTERFACE: NANOMATERIAL ENVIRONMENTAL IMPACTS AND POLICY (EI-NEIP)

CARNEGIE MELLON UNIVERSITY: NEW AWARD CONTROL NUMBER: 1970-1544 PROJECT TITLE: HIGH ENERGY DENSITY MODULAR HEAT EXCHANGERS THROUGH DESIGN, MATERIALS, PROCESSING, AND MANUFACTURING INNOVATIONS CARNEGIE MELLON UNIVERSITY WILL COORDINATE TO CHANGE WHAT IS POSSIBLE IN HEAT EXCHANGER TECHNOLOGY FOR ARPA-E BY DELIVERING A 900 °C, 250 BAR ULTRA-PERFORMANCE HEAT EXCHANGER ENABLED BY ADDITIVE TECHNOLOGY (UPHEAT).

BIOINFORMATICS PROGRAMS AT MINORITY INSTITUTIONS

SCALING HYDROGEN-DIRECT REDUCED IRON PATHWAYS TO DECARBONIZE IRON AND STEELMAKING

TO PROVIDE CAPACITY BUILDING TRAININGS TO EXPAND INTERNET AND ENHANCE CYBERSECURITY CAPABILITIES.

DISABILITY AND REHABILITATION RESEARCH PROGRAM: INCLUSIVE CLOUD AND WEB COMPUTING

MAPPING THE CELL SPECIFIC DNA DAMAGE-INDUCED MOLECULAR AND BIOELECTRICAL RESPONSES IN THE 3D CARDIAC UNIT - PROJECT SUMMARY THIS PROJECT WILL TEST THE HYPOTHESIS THAT DNA DAMAGE IN CARDIOMYOCYTES ACTIVATES P53 LEADING TO MITOCHONDRIAL ALTERATIONS AND SECRETION OF PARACRINE FACTORS THAT DRIVE HEART FAILURE. THE PREMISE FOR THIS HAS BEEN ESTABLISHED FROM OUR PRELIMINARY DATA AND FROM THE WORK OF OTHERS. FIRST, DNA DAMAGE AND ACTIVATED DNA DAMAGE RESPONSE (DDR) HAVE BEEN OBSERVED IN CARDIOVASCULAR DISEASE (CVD) IN HUMANS. SECOND, STUDIES ALSO SHOW EVIDENCE THAT MULTIPLE CELL TYPES IN THE CARDIAC UNIT, INCLUDING CARDIOMYOCYTES (CM) AND CARDIAC FIBROBLASTS (CF) DISPLAY MARKERS OF DNA DAMAGE AND CELLULAR SENESCENCE IN SEVERAL DISEASE PATHOLOGIES. THIRD, WE HAVE RECENTLY IDENTIFIED THAT NUCLEAR DNA DAMAGE DRIVES DILATED CARDIOMYOPATHY. SPECIFICALLY, CARDIOMYOCYTE-DEPLETION OF THE DNA REPAIR ENDONUCLEASE, ERCC1-XPF IN MICE, UPREGULATES THE DNA DAMAGE RESPONSE GENE, P53, AND LEADS TO IRREGULAR MITOCHONDRIAL CRISTAE, ACCUMULATION OF LIPIDS AND INCREASED OXIDATIVE STRESS. ADDITIONALLY, THERE IS AN INCREASE IN SEVERAL CARDIAC FAILURE AND SENESCENCE ASSOCIATED MARKERS. HOWEVER, THE EXACT MOLECULAR UNDERPINNINGS AND CELL-SPECIFICITY OF THESE DNA DAMAGE-INDUCED CHANGES IS POORLY UNDERSTOOD. ONE BARRIER TO ADDRESSING THIS QUESTION IN VIVO HAS BEEN LACK OF APPROPRIATE TOOLS, WHERE DNA DAMAGE CAN BE INTRODUCED IN ONLY ONE CELL TYPE (E.G., CM) AND ITS EFFECT ON CF AND CARDIAC FUNCTION CAN BE INVESTIGATED. ADDITIONALLY, 2D CELL CULTURE AND CO-CULTURE SYSTEMS FALL SHORT, AS THEY CANNOT REPRODUCE TISSUE DYNAMICS PRESENT IN A CARDIAC UNIT. HEREIN, WE HAVE DEVELOPED SEVERAL TOOLS ENABLE THE STUDY OF CELL-CELL COMMUNICATION OF 3D MULTICELLULAR SYSTEM. SPECIFIC AIM 1 WILL MAP THE MOLECULAR, FUNCTIONAL, AND ARCHITECTURAL CHANGES UPON LOSS OF ERCC1 IN CM. IN THIS AIM, WE WILL TEST THE MECHANISTIC ROLE OF P53 AND REACTIVE OXYGEN SPECIES ON A NUMBER OF CELLULAR AND MITOCHONDRIAL PARAMETERS, AS WELL AS CARDIOMYOCYTE ELECTROPHYSIOLOGY. SPECIFIC AIM 2 WILL TEST WHETHER STOCHASTIC, SPONTANEOUS DNA DAMAGE IN THE CM OR CF DRIVES CARDIAC ELECTROMECHANICAL DYSFUNCTION IN A CELL- AUTONOMOUS OR CELL NON-AUTONOMOUS MANNER THROUGH A PARACRINE EFFECT ON NEIGHBORING CELLS. HERE, WE WILL ANALYZE THE PATHOLOGICAL SECRETOME UPON GENOTOXIC STRESS, AS WELL AS TEST THE ROLE OF ELIMINATING SENESCENT CELLS ON CARDIAC HEALTH. THIS WORK IS TECHNICALLY INNOVATIVE AS IT USES A NUMBER OF UNIQUE TOOLS INCLUDING CONCOMITANT OPTICAL AND BIOELECTRICAL MEASUREMENTS IN 3D CARDIAC ORGANOIDS. THESE CONTRIBUTIONS WILL BE SIGNIFICANT BECAUSE DNA DAMAGE IS UNAVOIDABLE AND INTIMATELY LINKED TO CARDIAC HEALTH AND DISEASE. OUR TEAM IS UNIQUELY QUALIFIED TO PERFORM THIS WORK, WITH EXPERTISE IN DNA DAMAGE/ REPAIR, CELLULAR SENESCENCE, NANOFABRICATION, HUMAN IPSC- DERIVED CARDIAC TISSUE ENGINEERING, AND DATA SCIENCE. THIS ANALYSIS, WE BELIEVE, WILL INCREASE OUR FUNDAMENTAL UNDERSTANDING OF THE CONNECTION BETWEEN DNA DAMAGE AND HEART DISEASE AND POTENTIALLY PAVE THE WAY FOR NEW TREATMENT STRATEGIES.

NCRN-MN: DATA INTEGRATION, ONLINE DATA COLLECTION, AND PRIVACY PROTECTION FOR CENSUS 2020

BREAKTHROUGH MOLECULAR DYNAMICS RESEARCH VIA AN ANTON2 SUPERCOMPUTER

HCC: LARGE: SSCI-MISR: SYMBIOTIC SPATIAL COORDINATED HUMAN-ROBOT INTERACTION FOR MULTIPLE INDOOR SERVICE ROBOTS

OVERCOMING UNEXPECTED FAILURES USING NEUROCOGNITIVE MULTI-ABSTRACTION ACTIVE EXPLORATION ONR WHITE PAPER TRACKING NUMBER 23-000005331

REAPER: READING, EXTRACTION, AND ASSEMBLY OF PATHWAYS FOR EVIDENTIARY READING

PERSUASION, IDENTITY, & MORALITY IN SOCIAL-CYBER ENVIRONMENTS.

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH SUPPORTING THE DEFENSE ADVANCED RESEARCH PROJECTS AGENCY DARPA BIOLOGICAL TECHNOLOGIES OFFICES BTO DARPA TRIAGE CHALLENGE DTC PROGRAM. THIS EFFORT SHALL BE CARRIED OUT GENERALLY AS SET FORTH IN EXHIBIT B, RESEARCH DESCRIPTION DOCUMENT TRACK D, DATED OCTOBER 2, 2023, AND IN THE RECIPIENTS REVISED PROPOSAL TITLED, STRAPS STAND OFF TRIAGE WITH REALTIME ADVANCED PHYSIOLOGICAL SIGNATURES, DATED FEBRUARY 27, 2023, COPIES OF WHICH ARE IN THE POSSESSION OF BOTH PARTIES.

DOE TRAINEESHIP IN ROBOTICS

THIS GRANT SHALL BE PERFORMED IN ACCORDANCE WITH THE STATEMENT OF WORK ENTITLED, "PIEZOELECTRIC NON-LINEAR NANOMECHANICAL TEMPERATURE AND ACCELERATIO

FOWARD MODELING OF ELECTRON SCATTERING MODALITIES FOR MICROSTRUCTURAL QUANTIFICATION IN STRUCTURAL MATERIALS

INTELLIGENT SCIENCE STATIONS: DEVELOPING ADAPTIVE MIXED-REALITY TECHNOLOGY TO ENHANCE INQUIRY-BASED STEM LEARNING IN SCHOOLS -THE PROJECT AIMS TO DEVELOP AND RESEARCH INTELLIGENT SCIENCE STATIONS, A NEW GENRE OF INTERACTIVE SCIENCE EXPERIENCES. THE MOTIVATION BEHIND THIS PROJECT IS THE NEED FOR ENGAGING, INQUIRY-BASED SCIENCE LEARNING OPPORTUNITIES FOR YOUNG CHILDREN IN THE CLASSROOM, TO SUSTAIN EARLY INTEREST IN SCIENCE. THE INTELLIGENT SCIENCE STATIONS WILL PROVIDE STUDENTS IN KINDERGARTEN TO 4TH GRADE WITH HANDS-ON SCIENCE EXPERIENCES, AUGMENTED BY AN INTELLIGENT AGENT THAT OFFERS FEEDBACK BASED ON ARTIFICIAL INTELLIGENCE (AI) COMPUTER VISION. THESE INTELLIGENT SCIENCE STATIONS INCORPORATE SCIENTIFIC APPARATUSES SUCH AS EARTHQUAKE TABLES OR BALANCE SCALES, AND STUDENTS' ACTIONS ARE OBSERVED AND EVALUATED BY THE INTELLIGENT AGENT. THE AGENT APPEARS AS AN ANIMATED CHARACTER ON A SCREEN AND PROVIDES INTERACTIVE FEEDBACK TO GUIDE STUDENTS THROUGH SCIENTIFIC INQUIRY. THIS INNOVATIVE APPROACH OFFERS EVIDENCE-BASED, PERSONALIZED SUPPORT AND FEEDBACK TO CHILDREN, WHILE ALSO ASSISTING TEACHERS IN INTEGRATING MORE INQUIRY-BASED SCIENCE LEARNING INTO THEIR CLASSROOMS. BY MODELING BEHAVIORS LIKE ASKING QUESTIONS, MAKING PREDICTIONS, AND EXPLAINING SCIENTIFIC PHENOMENA, THE INTERACTIVE AI SYSTEM HELPS TEACHERS ENHANCE THEIR CLASSROOM EXPERIENCES. THE PROJECT AIMS TO DEVELOP FOUR INTELLIGENT SCIENCE STATIONS, EACH ACCOMPANIED BY LESSON PLANS, TEACHER PROFESSIONAL DEVELOPMENT, AND ONLINE RESOURCES SUCH AS VIDEO DEMONSTRATIONS AND LEARNING MATERIALS. THE SCIENCE CONTENT COVERED INCLUDES EARLY PHYSICS, BALANCE AND STABILITY, FORCES AND MOTION, FORCES AND INTERACTIONS, INQUIRY, AND ENGINEERING DESIGN. THE DEVELOPMENT AND RESEARCH WILL TAKE PLACE IN MULTIPLE SCHOOLS WITH STUDENTS FROM DIVERSE BACKGROUNDS, TARGETING AN ESTIMATED 3,000 STUDENTS PER SCHOOL YEAR OVER A THREE-YEAR PERIOD. THE EVALUATION AND RESEARCH COMPONENTS OF THE PROJECT HAVE TWO MAIN OBJECTIVES. FIRST, IT SEEKS TO ADVANCE SCIENTIFIC UNDERSTANDING BY INVESTIGATING THE LEARNING SUPPORT FEATURES THAT EFFECTIVELY ENGAGE CHILDREN IN SUSTAINED LEARNING EXPERIENCES INVOLVING SCIENTIFIC INQUIRY AND ENGINEERING DESIGN IN SCHOOL SETTINGS. SECOND, IT AIMS TO DETERMINE THE CURRICULAR AND LANGUAGE SUPPORTS NECESSARY TO FOSTER ENGAGEMENT AND ENHANCE SCIENCE LEARNING FOR CHILDREN WITH DIFFERENT BACKGROUNDS, ACADEMIC STRENGTHS, AND NEEDS. USER-CENTERED ITERATIVE DESIGN RESEARCH, FORMATIVE EVALUATION, AND CLASSROOM OBSERVATIONS WILL BE EMPLOYED TO DESIGN MIXED-REALITY SYSTEMS THAT BEST CATER TO STUDENT AND TEACHER LEARNING NEEDS IN FORMAL LEARNING ENVIRONMENTS. THROUGH CLASSROOM OBSERVATIONS AND CONTROLLED EXPERIMENTS, THE PROJECT WILL COMPARE BUSINESS AS USUAL CONDITIONS WITH THE USE OF INTELLIGENT SCIENCE STATIONS, PROVIDING INSIGHTS INTO STUDENT INQUIRY PROCESSES, SCIENCE CONVERSATIONS, STUDENT ENGAGEMENT, AND SCIENCE INQUIRY PROCESSES. THE PROJECT ALSO INTENDS TO SHARE ITS FINDINGS THROUGH PEER-REVIEWED PUBLICATIONS TARGETED AT RESEARCHERS AND DEVELOPERS, AS WELL AS PROVIDE EXTENSIVE PROFESSIONAL DEVELOPMENT RESOURCES AND VIDEO DEMONSTRATIONS TO TEACHERS AND EDUCATORS VIA SOCIAL MEDIA AND THE PROJECT WEBSITE. THE DISCOVERY RESEARCH PREK-12 PROGRAM (DRK-12) SEEKS TO SIGNIFICANTLY ENHANCE THE LEARNING AND TEACHING OF SCIENCE, TECHNOLOGY, ENGINEERING AND MATHEMATICS (STEM) BY PREK-12 STUDENTS AND TEACHERS, THROUGH RESEARCH AND DEVELOPMENT OF INNOVATIVE RESOURCES, MODELS AND TOOLS. PROJECTS IN THE DRK-12 PROGRAM BUILD ON FUNDAMENTAL RESEARCH IN STEM EDUCATION AND PRIOR RESEARCH AND DEVELOPMENT EFFORTS THAT PROVIDE THEORETICAL AND EMPIRICAL JUSTIFICATION FOR PROPOSED PROJECTS.? THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

TAS:: 97 0400::TAS RECONCILING PURPOSE, DATA PRIVACY, AND USER PREFERENCES: A HOLISTIC APPROACH TO MANAGING PRIVACY

EFFICIENT AND COST-EFFECTIVE MULTIMODAL SYSTEM FOR PAIN MANAGEMENT IN LOW BACK PAIN

ELUCIDATE MECHANISMS OF QUINOLONE ALKALOID BIOSYNTHESIS VIA IRON(II)/2-OXOGLUTARATE DEPENDENT ENZYMES: DIVERSE, BUT CONTROLLED REACTIVITY

MECHANISM AND ROLE OF MEMBRANE FUSION BY THE ATLASTIN GTPASE

MINDFULNESS MEDITATION TRAINING IN LONELY OLDER ADULTS

IGERT: USABLE PRIVACY AND SECURITY

SIRNA DELIVERY BY NANOSTRUCTURED POLYMERS TO PREVENT HETEROTOPIC OSSIFICATION IN COMBAT POLYTRAUMA

CO-ROBOTIC GAMES FOR LOW RESOURCE LEARNERS

COLLABORATIVE RESEARCH: COMPUTATIONAL PHOTO-SCATTEROGRAPHY: UNRAVELING SCATTERED PHOTONS FOR BIO-IMAGING

CSR: CHS: LARGE: WEARABLE COGNITIVE ASSISTANCE

DEVELOPING THE SCIENTIFIC UNDERPINNING OF BIOWARFARE AGENT DISCLOSURE SPRAYS

AUTOMATED EARLY WARNING SYSTEM FOR CYBER-INTRUSION DETECTION

COMPUTATIONAL METHODS FOR NEXT-GENERATION COMPARATIVE GENOMICS

CIRCUIT-INSPIRED STRATEGIES TO RESTORE BASAL GANGLIA FUNCTION IN MOUSE MODELS OF PARKINSON?S DISEASE - PROJECT SUMMARY THE EXTERNAL SEGMENT OF THE GLOBUS PALLIDUS (GPE) IS A NEURONALLY DIVERSE AND HIGHLY INTERCONNECTED NUCLEUS WITHIN THE BASAL GANGLIA. UNDER CONDITIONS OF LOW DOPAMINE, PLASTICITY IN THE GPE PROMOTES THE EMERGENCE OF PATHOLOGICAL FIRING PATTERNS THAT CONTRIBUTE TO WIDESPREAD BASAL GANGLIA DYSFUNCTION. IN PARKINSON’S DISEASE (PD), DEEP BRAIN STIMULATION (DBS) IN THE GPE CAN ALLEVIATE MOTOR SYMPTOMS, SUGGESTING THERE IS A MECHANISTIC LINK BETWEEN NEURONAL DYSFUNCTION IN THE GPE AND MOTOR SYMPTOMS OF PD. USING OPTOGENETICS TO TARGET NEURONAL SUBPOPULATIONS IN THE GPE, WE DISCOVERED THAT PERSISTENT BEHAVIORAL RESCUE COULD BE INDUCED BY INTERVENTIONS THAT EXCITED PARVALBUMIN-EXPRESSING GPE NEURONS (PV-GPE) AND INHIBITED LIM HOMEOBOX 6-EXPRESSING GPE NEURONS (LHHX6-GPE). DIFFERENCES IN THE SYNAPTIC INPUTS ONTO THESE NEURONAL SUBPOPULATIONS ENABLED US TO DEVELOP A HUMAN-TRANSLATABLE ELECTRICAL DBS PROTOCOL THAT COULD ACHIEVE THE SAME CELL-TYPE SPECIFICITY OF OPTOGENETICS. IN PARKINSONIAN MICE, THESE CIRCUIT-INSPIRED BURST DBS PROTOCOLS PROVIDED SUPERIOR THERAPEUTIC BENEFIT OVER CONVENTIONAL PROTOCOLS, EXTENDING THE THERAPEUTIC DURATION FOR HOURS BEYOND THE PERIOD OF ACTIVE STIMULATION. WE ARE NOW COLLABORATING WITH NEUROSURGEONS AT ALLEGHENY GENERAL IN PITTSBURGH TO TEST THE THERAPEUTIC EFFICACY OF CIRCUIT-INSPIRED DBS PROTOCOLS IN HUMANS. RESULTS FROM IN VIVO PHYSIOLOGICAL RECORDINGS REVEALED THAT GPE INTERVENTIONS REVERSE PARKINSONIAN PATHOPHYSIOLOGY IN THE BASAL GANGLIA FOR HOURS FOLLOWING STIMULATION, RAISING THE INTRIGUING POSSIBILITY THAT GPE INTERVENTIONS INDUCE THERAPEUTIC PLASTICITY THAT RESTORES CIRCUIT FUNCTION IN DISEASE. THIS WOULD REPRESENT A TRANSFORMATIVE ADVANCE IN PD THERAPEUTICS. BUT A NUMBER OF QUESTIONS STILL REMAIN ABOUT HOW TRANSIENT INTERVENTIONS IN THE GPE TRANSLATE INTO LONG-LASTING THERAPEUTIC EFFECTS AT THE BEHAVIORAL LEVEL. THIS PROPOSAL WILL USE ELECTROPHYSIOLOGICAL, OPTOGENETIC, AND BEHAVIORAL APPROACHES TO IDENTIFY THE THERAPEUTIC MECHANISMS OF PERSISTENT BEHAVIORAL RESCUE BY ACHIEVING THREE MAIN GOALS: (1) WE WILL MAP THE NEURAL PATHWAYS REQUIRED FOR PERSISTENT BEHAVIORAL RESCUE, INCLUDING TESTING AN INNOVATIVE HYPOTHESIS THAT BOTH MOTOR AND AROUSAL CIRCUITS ARE INVOLVED (2) WE WILL IDENTIFY SHORT-TERM AND LONG-TERM EFFECTS OF GPE INTERVENTIONS ON BASAL GANGLIA PHYSIOLOGY, TESTING THE HYPOTHESIS THAT GPE INTERVENTIONS DRIVE THERAPEUTIC PLASTICITY IN DOPAMINE DEPLETED MICE, AND (3) WE WILL ASSESS THE THERAPEUTIC EFFICACY OF GPE INTERVENTIONS DELIVERED AT DIFFERENT STAGES OF DOPAMINE DEPLETION ON BOTH MOTOR AND NON-MOTOR SYMPTOMS TO FURTHER STUDY THE NEURAL CIRCUITS INVOLVED, AS WELL AS TO ADVANCE PRECLINICAL TESTING OF GPE INTERVENTIONS FOR CONTINUED THERAPEUTIC DEVELOPMENT. THESE STUDIES WILL ADVANCE THE DEVELOPMENT OF CIRCUIT-INSPIRED APPROACHES THAT REPAIR, RATHER THAN MASK CIRCUIT DYSFUNCTION FOR LONG-TERM RECOVERY OF BRAIN FUNCTION IN DISEASE.

DBS PROTOCOLS FOR LONG-LASTING THERAPEUTIC BENEFIT IN MOUSE AND PRIMATE MODELS OF PARKINSON'S DISEASE

MID-LEVEL PLANNING AND CONTROL FOR ARTICULATED LOCOMOTING SYSTEMS

TC:LARGE:NUDGING USERS TOWARDS PRIVACY

TAS:97:0400:TAS GENERATING HYPER-PORTABLE FUTURE-PROOF COMPUTATIONAL KERNALS WITH SPIRAL

UNIFIED SCALABLE COMPUTATIONAL GAME THEORY

COMBINED USE OF POLYCARBOXYBETAINE COATINGS WITH A SELECTIVE FXIIA INHIBITOR TO CREATE POTENT BIOMATERIAL ANTICOAGULATION WITHOUT BLEEDING DURING EXTRACORPOREAL LIFE SUPPORT - ABSTRACT OVER 190,000 PEOPLE SUFFER FROM ACUTE RESPIRATORY DISTRESS SYNDROME IN THE US EACH YEAR, WITH MORTALITY RATES FROM 30-40% WITH THE BEST TREATMENT. IN ADDITION, THERE ARE OVER 12 MILLION PATIENTS WITH CHRONIC LUNG DISEASE, 6.9 MILLION EMERGENCY ROOM VISITS, AND OVER 180,000 DEATHS. WHEN MECHANICAL VENTILATION IS INSUFFICIENT TO SUPPORT THESE PATIENTS, EXTRA-CORPOREAL MEMBRANE OXYGENATION (ECMO) IS USED AS A BRIDGE TO RECOVERY OR BRIDGE TO TRANSPLANTATION. UNFORTUNATELY, ECMO IS PLAGUED BY BLEEDING AND THROMBOTIC COMPLICATIONS THAT REDUCE PATIENT SURVIVAL BY APPROXIMATELY 40 AND 33%, RESPECTIVELY. THE CAUSE OF COAGULATION IS PRIMARILY SURFACE ADSORPTION OF PLASMA PROTEINS, SUBSEQUENT ACTIVATION OF THE INTRINSIC BRANCH OF THE COAGULATION CASCADE, AND PLATELET BINDING TO ADSORBED FIBRINOGEN. THIS IS COMBATED USING SYSTEMIC, INTRAVENOUS HEPARIN, BUT THIS INHIBITS BOTH BIOMATERIAL- INDUCED COAGULATION IN THE ECMO CIRCUIT AND TISSUE-FACTOR INDUCED COAGULATION IN THE PATIENT’S TISSUES, RESULTING IN BLEEDING COMPLICATIONS. TO ELIMINATE BOTH OF THESE PROBLEMS SIMULTANEOUSLY, WE PROPOSE TO COMBINE TWO MEANS OF SELECTIVELY INHIBITING COAGULATION AT THE BLOOD-BIOMATERIAL INTERFACE WHILE LEAVING TISSUE-BASED COAGULATION INTACT. THE FIRST IS BIOMATERIAL SURFACE COATING WITH ZWITTERIONIC POLYCARBOXYBETAINE (PCB). OUR INITIAL RESULTS DEMONSTRATE THAT THE PCB COATING DRAMATICALLY DECREASES PROTEIN ADSORPTION AND PLATELET BINDING IN VITRO AND LONG-TERM CLOT FORMATION DURING SHEEP ECMO. THE SECOND IS FXII900, A POTENT, HIGHLY-SELECTIVE BICYCLIC PEPTIDE FXIIA INHIBITOR. FXII900 INHIBITS SURFACE-INDUCED ACTIVATION OF COAGULATION AT NANOMOLAR CONCENTRATIONS WITHOUT AFFECTING THE TISSUE-BASED EXTRINSIC BRANCH OR COMMON BRANCH OF THE COAGULATION CASCADE. IN OUR PRELIMINARY, SHORT-TERM RABBIT ECMO STUDIES, WE DEMONSTRATE A 94% REDUCTION IN CLOT FORMATION VS. STANDARD CLINICAL HEPARIN ANTICOAGULATION. AT THE SAME TIME, FXII900 PLUS PCB MAINTAINED A NORMAL BLEEDING TIME, WHILE THE HEPARIN INCREASED THE BLEEDING TIME TO 2.9 TIMES NORMAL. THE GOALS OF THIS PROPOSAL ARE TO EXTEND THIS TECHNOLOGY TOWARD CLINICAL APPLICATIONS BY I) PROVING THE EFFECTIVENESS OF COMBINED PCB PLUS FXII900 ANTICOAGULATION DURING 5-DAY IN VIVO EXTRACORPOREAL LIFE SUPPORT AND II) DEVELOPING LONG-ACTING FXII900 FORMULATIONS THAT ENABLE BOLUS DOSING EVERY 8 OR 12 HOURS RATHER THAN A CONTINUOUS INTRAVENOUS DRIP. IF SUCCESSFUL, THESE STUDIES WOULD LEAD TO A CLINICAL ANTICOAGULATION STRATEGY THAT I) REDUCES BLEEDING AND THROMBOTIC COMPLICATIONS DURING ECMO, II) REDUCES ECMO MORTALITY, AND III) SIMPLIFIES CLINICAL APPLICATION OF ECMO. THESE BENEFITS, WHEN COMBINED, MIGHT ALSO ALLOW SAFE LONG-TERM ECMO OUTSIDE THE INTENSIVE CARE UNIT.

BI-DIRECTIONAL HYBRID AI FOR ROBUST AUTONOMY

INNOVATIVE SUPERCOMPUTING FOR BREAKTHROUGH MOLECULAR DYNAMICS

MINDFULNESS MEDITATION TRAINING FOR IRRITABLE BOWEL SYNDROME - PROJECT SUMMARY/ABSTRACT MINDFULNESS-BASED INTERVENTION (MBI) TRAINING PROGRAMS HAVE BEEN SHOWN TO REDUCE STRESS AND IMPROVE A BROAD RANGE OF STRESS-RELATED DISEASE OUTCOMES IN INITIAL RANDOMIZED CONTROLLED TRIALS (RCTS). FOR EXAMPLE, THERE IS INITIAL EVIDENCE FROM SMALL RCTS THAT MBIS REDUCE SYMPTOMS IN IRRITABLE BOWEL SYNDROME (IBS) PATIENTS. YET WE KNOW LITTLE ABOUT THE UNDERLYING ACTIVE TREATMENT MECHANISMS OF MINDFULNESS TRAINING. GUIDED BY A THEORETICAL AND CONCEPTUAL MODEL OF THE ACTIVE TREATMENT ELEMENTS OF MBIS, CALLED MONITOR AND ACCEPTANCE THEORY (MAT), WE RECENTLY SHOWED IN TWO PUBLISHED DISMANTLING MBI RCTS THAT ACCEPTANCE SKILLS TRAINING IS CRITICAL FOR DRIVING STRESS REDUCTION EFFECTS IN HEALTHY STRESSED COMMUNITY ADULTS. SPECIFICALLY, STANDARD MBI PROGRAMS WITH ATTENTION MONITORING AND ACCEPTANCE SKILLS TRAINING WERE SUPERIOR IN REDUCING STRESS RELATIVE TO PARALLEL MBI PROGRAMS THAT DID NOT INCLUDE ACCEPTANCE SKILLS TRAINING (OR TO CONTROL GROUPS) AT POST-TREATMENT. WE OBSERVED CONSISTENT STRESS REDUCTION EFFECTS ACROSS INTERVENTION DELIVERY APPROACHES IN THESE TWO DISMANTLING TRIALS, USING EITHER A 2-WEEK REMOTE SMARTPHONE MBI OR WITH AN 8-WEEK GROUP-BASED MINDFULNESS-BASED STRESS REDUCTION (MBSR) MBI TREATMENT APPROACH. HERE WE PROPOSE THE FIRST TRANSLATIONAL TRIAL OF THIS MECHANISTIC ACCOUNT, EXAMINING WHETHER ACCEPTANCE SKILLS TRAINING DRIVES STRESS RESILIENCE AND IMPROVED SYMPTOM OUTCOMES IN IBS PATIENTS. IN THE LARGEST AND MOST WELL-CONTROLLED RCT OF MBI TRAINING IN IBS TO-DATE (N=325), WE WILL EVALUATE WHETHER A SMARTPHONE MBI PROGRAM (WITH ATTENTION MONITORING AND ACCEPTANCE SKILLS TRAINING; MONITOR+ACCEPT, MA-MBI) REDUCES DAILY LIFE STRESS AND IBS SYMPTOMS AT POST-TREATMENT AND TWO-MONTH FOLLOW-UP, RELATIVE TO A MATCHED MBI PROGRAM WITH ACCEPTANCE SKILLS TRAINING REMOVED (TRAINING IN ATTENTION MONITORING SKILLS ONLY; MONITOR ONLY, MO-MBI) OR TO AN ACTIVE STRESS MANAGEMENT TRAINING CONTROL GROUP (COPING CONTROL, CC). PARTICIPANTS WILL NOT ONLY PROVIDE CLINICIAN AND PATIENT ASSESSED MEASURES OF IBS SYMPTOMS AT THE THREE TIME POINTS, BUT THEY WILL ALSO PROVIDE SENSITIVE EXPERIENCE SAMPLING ASSESSMENTS (USING ECOLOGICAL MOMENTARY ASSESSMENT) OF THEIR STRESS AND SYMPTOMS IN DAILY LIFE AT EACH TIME POINT. FINALLY, AS AN EXPLORATORY AIM, PARTICIPANTS WILL PROVIDE STOOL SAMPLES AT BASELINE AND POST-INTERVENTION TO PROVIDE THE FIRST EVER TEST OF WHETHER MBIS CAN ALTER THE GUT MICROBIOME IN IBS. GUIDED BY A CONCEPTUAL MODEL, THE PROPOSED STUDY WILL EXPERIMENTALLY EVALUATE WHETHER ACCEPTANCE SKILLS TRAINING IS A KEY INGREDIENT FOR STRESS REDUCTION AND HEALTH BENEFITS IN IBS PATIENTS, AND WILL PROVIDE AN IMPORTANT MECHANISTICALLY-FOCUSED EVALUATION OF THE ACTIVE TREATMENT ELEMENTS OF MBIS FOR AT RISK STRESSED PATIENT POPULATIONS. WE BELIEVE THAT THIS TRIAL NOT ONLY CAN HELP IDENTIFY A NEW ACCESSIBLE AND SCALABLE EVIDENCE-BASED TREATMENT FOR IBS PATIENTS, BUT THE MECHANISTIC FOCUS WILL ALSO HELP THE FIELD ADVANCE MORE EFFECTIVE AND EFFICIENT ACCEPTANCE SKILLS-BASED MINDFULNESS TRAINING APPROACHES AMONG AT-RISK STRESSED PATIENT POPULATIONS.

HIGHLY MULTIPLEXED NANOSCALE IMAGING PLATFORMS FOR PROFILING AND INTERROGATION OF COMPLEX DISEASES

A VALUE AFFIRMATION INTERVENTION FOR PHYSICAL SYMPTOMS AND MEDICATION ADHERENCE IN BREAST CANCER PATIENTS TAKING AROMATASE INHIBITORS

III: LARGE: DISCOVERING COMPLEX ANOMALOUS PATTERNS

NATIONAL CENTER FOR EDUCATION RESEARCH

PHASE SEPARATION-INDUCED NUCLEAR ORGANIZATION IN ALT CANCER

FORMATION AND TUNING OF COMPLEX AUDITORY CATEGORIES

TAS::57 3600::TAS "TRUSTWORTHY HUMAN INTERACTION WITH ROBOTIC SWARMS"

EPR AND MOSSBAUER CHARACTERIZATION OF MN AND FE PROTIENS, PROTINS, MODELS, INTER

TARGETED FLUORESCENT INDICATORS FOR ENDOTHELIAL PHYSIOLOGY: CA(II), ROS, NO

GENOME-TRANSCRIPTION-PHENOME-WIDE ASSOCIATION: A NEW PARADIGM FOR ASSOCIATION STU

TAS::97 0400::TAS NEVER-ENDING LEARNING FOR DEEP UNDERSTANDING OF NATURAL LANGUAGE

CELL RESPONSE TO 3D ENGINEERED GRADIENTS OF FGF-2

DETERMINANTS OF SPARSE ACTIVITY IN NEOCORTEX - ABSTRACT SYNAPTIC PLASTICITY IN NEOCORTICAL NEURONS IS INTIMATELY TIED TO LEARNING AND MEMORY. DECADES OF RESEARCH IN ACUTE BRAIN SLICES HAVE CHARACTERIZED THE PATTERNS OF SPIKE TIMING REQUIRED TO EVOKE SYNAPTIC CHANGE IN MINUTE DETAIL, BUT IT REMAINS UNKNOWN WHETHER THESE CONDITIONS OCCUR AND ARE SUFFICIENT TO DRIVE SYNAPTIC PLASTICITY IN THE LIVING BRAIN. INDEED, IN VIVO RECORDINGS INDICATE THAT NEOCORTICAL NEURONS LIVE IN AN ENVIRONMENT OF PROFOUND INHIBITION THAT LOWERS OVERALL FIRING RATES AND PREVENTS PLASTICITY. HOW THEN DO CORTICAL NEURONS ESCAPE THIS INHIBITION TO ENCOUNTER APPROPRIATE CONDITIONS FOR PLASTICITY DURING LEARNING? NEW EVIDENCE SUGGESTS THAT PARVALBUMIN (PV) GABAERGIC NEURONS MAY PLAY A DOMINANT ROLE IN REGULATING CORTICAL ACTIVITY AND CONTROLLING NETWORK REWIRING, PARTICULARLY AT THE EARLY STAGES OF LEARNING. USING A MULTIWHISKER STIMULUS COUPLED TO A WATER REWARD, WE HAVE DEVELOPED A PARADIGM FOR SENSORY ASSOCIATION LEARNING THAT DRIVES RAPID CHANGES IN EXCITATORY SYNAPTIC STRENGTH IN MOUSE BARREL CORTEX. IMPORTANTLY, OUR NEW DATA INDICATE THAT PV OUTPUT TO NEOCORTICAL PYRAMIDAL NEURONS IS MARKEDLY SUPPRESSED AT THE EARLIEST STAGES OF SENSORY TRAINING. OUR EXPERIMENTS WILL INTEGRATE IN VIVO AND ACUTE BRAIN SLICE RECORDINGS TO TEST THE HYPOTHESIS THAT PV NEURONS ARE A DOMINANT REGULATOR OF SENSORY- EVOKED ACTIVITY IN MOUSE BARREL CORTEX. WE PROPOSE THAT REWARD-RELATED ACETYLCHOLINE RELEASE INDIRECTLY SUPPRESSES PV NEURAL FIRING TO DEPRESS PV OUTPUT AND INCREASE SENSORY-EVOKED ACTIVITY DURING LEARNING. OUR EXPERIMENTS WILL IDENTIFY MECHANISMS FOR CORTICAL DISINHIBITION THAT FACILITATE EXPERIENCE-DEPENDENT SYNAPTIC PLASTICITY IN SENSORY CORTEX.

DRRP ON ROBOTICS AND AUTOMATION FOR INCLUSIVE TRANSPORTATION

HIGH THROUGHPUT APPROACHES FOR CELL-SPECIFIC SYNAPSE CHARACTERIZATION

3D CARBON-NANOTUBES INTEGRATED MICRODEVICE FOR EXTRACELLULAR VESICLE ISOLATION AND IN SITU SAMPLE PREPARATION TOWARDS NONINVASIVE PANCREATIC CANCER DIAGNOSIS

ELUCIDATION AND MODULATION OF LIGAND-DRIVEN SEGREGATION IN MULTICOMPONENT HYBRID PARTICLES FOR DYNAMIC ASSEMBLY OF NANOSTRUCTURES

ELECTROPHYSIOLOGICAL SOURCE IMAGING GUIDED TRANSCRANIAL FOCUSED ULTRASOUND

GENETIC CONTROL OF C. ALBICANS BIOFILM FORMATION

IMAGING EPILEPSY SOURCES WITH BIOPHYSICALLY CONSTRAINED DEEP NEURAL NETWORKS - PROJECT SUMMARY THE GOAL OF THIS PROJECT IS TO DEVELOP AND VALIDATE A NOVEL ELECTROPHYSIOLOGICAL SOURCE IMAGING (ESI) APPROACH BASED ON BIOPHYSICALLY CONSTRAINED DEEP NEURAL NETWORKS (BIODNN), TO SIGNIFICANTLY IMPROVE SURGICAL PLANNING IN DRUG RESISTANT FOCAL EPILEPSY PATIENTS. EPILEPSY AFFECTS ABOUT 70 MILLION PEOPLE WORLDWIDE. FOR APPROXIMATELY 33% OF THE 3.4 MILLION AMERICANS WITH EPILEPSY, SEIZURES ARE NOT CONTROLLED BY MEDICATIONS ALONE. EPILEPSY SURGERY IS THE MOST VIABLE OPTION FOR CURING DRUG RESISTANT FOCAL EPILEPSY, ONLY IF SEIZURE SOURCES CAN BE ACCURATELY LOCALIZED AND SAFELY REMOVED. THERE IS A CLINICAL NEED TO INNOVATE TECHNOLOGICAL TOOLS FOR BETTER SURGICAL PLANNING OF FOCAL EPILEPSY. WE PROPOSE IN THIS PROJECT A NOVEL ESI TECHNOLOGY BASED ON BIOPHYSICALLY CONSTRAINED DEEP NEURAL NETWORK (BIODNN) TO PROVIDE ACCURATE, ROBUST, AND OBJECTIVE SPATIO-TEMPORAL ESTIMATES OF THE UNDERLYING EPILEPTOGENIC ZONE (EZ). OF INNOVATION IS THAT THE TRAINED NEURAL NETWORK, IS CAPABLE OF IMAGING BRAIN SOURCES WITHOUT THE NEED TO TUNE THE MODEL’S HYPER-PARAMETERS BY AN OPERATOR FOR EVERY NEW INSTANCE OF DATA, THUS MAKING THE TECHNIQUE OBJECTIVE AND EASY-TO-USE IN CLINICAL SETTINGS. OUR SPECIFIC AIMS ARE: AIM 1. ESTABLISHING AND VALIDATING THE BIODNN FOR IMAGING EPILEPTOGENIC TISSUE FROM EEG INTER-ICTAL EPILEPTIFORM DISCHARGES (IEDS) OF FOCAL EPILEPSY PATIENTS. WE WILL ESTABLISH, OPTIMIZE AND VALIDATE THE PROPOSED BIODNN FOR IMAGING EZ FROM IEDS IN EEG IN 200 FOCAL DRUG RESISTANT EPILEPSY (DRE) PATIENTS, IN COMPARISON TO CLINICAL “GROUND TRUTH". AIM 2. DEVELOPING AND VALIDATING THE BIODNN MODEL FOR IMAGING EPILEPTOGENIC TISSUE FROM MEG INTER-ICTAL EPILEPTIFORM DISCHARGES OF FOCAL EPILEPSY PATIENTS. WE WILL DEVELOP AND OPTIMIZE THE BIODNN MODEL FOR IMAGING EZ FROM MEG IEDS AND VALIDATE THE MEG-BIODNN MODEL AND COMPARE WITH THE EEG-BIODNN MODEL IN 80 FOCAL DRE PATIENTS IN COMPARISON TO CLINICAL “GROUND TRUTH. AIM 3. DEVELOPING AND VALIDATING THE BIODNN MODEL FOR IMAGING EPILEPTOGENIC TISSUE FROM ICTAL EEG OF FOCAL EPILEPSY PATIENTS. WE WILL DEVELOP THE BIODNN FOR IMAGING THE SOZ FROM SCALP ICTAL EEG AND VALIDATE IT FROM HIGH DENSITY ICTAL EEG RECORDINGS IN 120 FOCAL DRE PATIENTS, IN COMPARISON TO CLINICAL “GROUND TRUTH”. THE SUCCESSFUL COMPLETION OF THE PROPOSED RESEARCH WILL ESTABLISH A NOVEL MACHINE LEARNING TECHNOLOGY TO NON-INVASIVELY LOCALIZE AND IMAGE UNDERLYING EPILEPTOGENIC TISSUE FROM INTERICTAL AND ICTAL ELECTROPHYSIOLOGICAL BIOMARKERS. THE ESTABLISHMENT OF SUCH A NOVEL TECHNOLOGY PROMISES TO SIGNIFICANTLY IMPROVE THE PRECISION OF INTRACRANIAL EEG ELECTRODES IMPLANTATION AND AID SURGICAL PLANNING, LEADING TO SIGNIFICANT IMPROVEMENT IN SURGICAL OUTCOMES, AND BENEFITING NUMEROUS DRUG RESISTANT EPILEPSY PATIENTS. 1

AUTOMATED HIGH-THROUPUT ESTIMATION AND MODELING OF PROTEIN NETWORK DISTRIBUTIONS

THIS GRANT SHALL BE PREFORMED IN ACCORDANCE WITH THE STATEMENT OF WORK (ATTACHMENT 2), ENTITLED 'SPLIT CHIP DESIGN FOR OBFUSCATION AND IC TRUST', DAT

NEW; SISGR-QUANTIFYING DAMAGE ACCUMULATION DURING DUCTILE PLASTIC DEFORMATION USING SYNCHROTRON RADIATION; PI- ROBERT SUTER

CPS: LARGE: CENTER FOR AUTONOMOUS TRANSPORTATION SYSTEMS