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EDUCATION, RESEARCH, MEDICAL SERVICES AND OTHER PUBLIC SERVICES.
Source: IRS Form 990 (Tax Year 2024)
Source: IRS e-Filed Form 990 (from the IRS e-File system), Tax Year 2023
Total Revenue
▼$6.6B
Program Spending
93%
of total expenses go to program services
Total Contributions
$621.6M
Total Expenses
▼$6.4B
Total Assets
$18.6B
Total Liabilities
▼$4.8B
Net Assets
$13.8B
Officer Compensation
→$14.9M
Other Salaries
$3B
Investment Income
$705.1M
Fundraising
▼$311.1K
Tax Year 2023 · Source: IRS Form 990, Schedule I (Grants and Other Assistance)
Total grants awarded: $120.8M
| Recipient | Location | Amount | Type | Purpose |
|---|---|---|---|---|
SLOAN KETTERING INSTITUTE13-1924236 | NEW YORK, NY | $6.2M | Cash | Research |
JOHN HOPKINS UNIVERSITY52-0595110 | CHICAGO, IL | $4.1M | Cash | Research |
COLUMBIA UNIVERSITY13-5598093 | NEW YORK, NY | $3.8M | Cash | Research |
UNIVERSITY OF ILLINOIS37-6000511 | CHICAGO, IL | $3.4M | Cash | Research |
UNIVERSITY OF MASSACHUSETTS | WORCESTER, MA | $2.9M | Cash | Research |
BRIGHAM & WOMENS HOSPITAL INC | BOSTON, MA | $2.8M | Cash | Research |
| LOS ANGELES, CA | $2.7M | Cash | Research-Mechanical Engineering | |
UNIVERSITY OF CALIFORNIA LOS ANGELES95-6006143 | LOS ANGELES, CA | $2.4M | Cash | Research |
RUTGERS STATE UNI OF NJ22-6001086 | PISCATAWAY, NJ | $2.4M | Cash | Research |
University of Florida59-6002052 | Gainesville, FL | $2.3M | Cash | Research |
Board of Trustees Leland Stanford Univ94-1156365 | Stanford, CA | $2.2M | Cash | Research |
DUKE UNIVERSITY56-0532129 | CHARLOTTE, NC | $2.1M | Cash | Research-Agricultural Sciences |
YALE UNIVERSITY GRANTS AND CONTRACT | NEW HAVEN, CT | $2.1M | Cash | Research |
University of Notre Dame du Lac35-0868188 | Notre Dame, IN | $2M | Cash | Research-Physics |
HARVARD UNIVERSITY | CAMBRIDGE, MA | $1.9M | Cash | Research |
RESEARCH FOUND FOR THE STATE UNI OF NY14-1368361 | ALBANY, NY | $1.8M | Cash | Research |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY | CAMBRIDGE, MA | $1.8M | Cash | Research |
REGENTS THE UNIVERSITY OF MICHIGAN38-6006309 | Ann Arbor, MI | $1.8M | Cash | Research |
UNIV OF PGHCMLTH SYS OF HIGHER ED25-0965591 | Pittsburgh, PA | $1.6M | Cash | Research |
Board of Regents of the UW System39-6006492 | Madison, WI | $1.6M | Cash | Research |
UNIVERSITY OF VIRGINIA54-6001796 | CHARLOTTESVILLE, VA | $1.5M | Cash | Research |
ROCKEFELLER UNIVERSITY13-1624158 | NEW YORK, NY | $1.4M | Cash | Research |
HACKENSACK UNIV MEDICAL CENTER22-1487576 | NUTLEY, NJ | $1.4M | Cash | Research |
New York University13-5562308 | New York, NY | $1.4M | Cash | Research-Physics |
UNIVERSITY OF ALABAMA AT BIRMINGHAM63-6005396 | BIRMINGHAM, AL | $1.4M | Cash | Research |
Regents Of the University of California94-6002123 | Merced, CA | $1.3M | Cash | Research |
TULANE UNIVERSITY HEALTH72-0423889 | NEW ORLEANS, LA | $1.2M | Cash | Research |
NEW YORK GENOME CENTER INC80-0631734 | NEW YORK, NY | $1.1M | Cash | Research |
Sathguru Inc80-0664005 | Quincy, MA | $1.1M | Cash | Research-Life Sciences |
| CHAPEL HILL, NC | $1.1M | Cash | Research-Biological & Biomedical Sciences | |
UNIVERSITY OF MINNESOTA41-6007513 | MINNEAPOLIS, MN | $1M | Cash | Research |
Boyce Thompson Inst for Plant Rsh Inc13-1739923 | Ithaca, NY | $1M | Cash | Research |
FRED HUTCHINSON23-7156071 | SEATTLE, WA | $1M | Cash | Research |
| Santa Barbara, CA | $1M | Cash | Research | |
BOSTON MEDICAL CENTER CORPORATION | BOSTON, MA | $996.9K | Cash | Research |
State of Maryland52-6002033 | Baltimore, MD | $991.4K | Cash | Research |
UNIVERSITY OF CHICAGO36-2177139 | CHICAGO, IL | $991.4K | Cash | Research |
ICAHN SCHOOL OF MEDICINE AT MOUNT13-6171197 | NEW YORK, NY | $981.8K | Cash | Research |
HOSPITAL FOR SPECIAL SURGERY13-1624135 | NEW YORK, NY | $966.5K | Cash | Research-Biological & Biomedical Sciences |
UT SOUTHWESTERN MEDICAL CENTER75-6002868 | DALLAS, TX | $885.7K | Cash | Research |
| Miami, FL | $867.9K | Cash | Research | |
Concepts Inc52-2029941 | Bethesda, MD | $858.1K | Cash | Research |
ARIZONA STATE UNIVERSITY86-0196696 | TEMPE, AZ | $857.6K | Cash | Research |
WASHINGTON UNIVERSITY IN ST LOUIS43-0653611 | ST LOUIS, MO | $838.8K | Cash | Research |
NORTHWESTERN UNIVERSITY36-2167817 | EVANSTON, IL | $831.8K | Cash | Research |
UNIVERSITY OF PENNSYLVANIA23-1352685 | PHILADELPHIA, PA | $798.7K | Cash | Research-Other Engineering |
BOSTON CHILDRENS HOSPITAL | BOSTON, MA | $789.3K | Cash | Research |
REGENTS OF THE UCLA DAVIS | LOS ANGELES, CA | $787.7K | Cash | Research |
ST JUDE CHILDRENS RESEARCH HOSPITAL85-2379541 | MEMPHIS, TN | $762K | Cash | Research |
The University of Arizona74-2652689 | Tucson, AZ | $741.9K | Cash | Research |
UNIVERSITY OF CALIFORNIA SAN DIEGO95-6006144 | LOS ANGELES, CA | $724.9K | Cash | Research |
North Carolina State University56-6000756 | Raleigh, NC | $715.3K | Cash | Research |
DANA FARBER CANCER INSTITUTE | BOSTON, MA | $710.5K | Cash | Research-Bioengineering/Biomedical Engineering |
RESEARCH FOUNDATION OF CUNY13-1988190 | NEW YORK, NY | $702.4K | Cash | Research |
SCRIPPS RESEARCH INSTITUTE33-0435954 | LOS ANGELES, CA | $677.4K | Cash | Research |
Clemson University57-6000254 | Clemson, SC | $650.1K | Cash | Research-Agricultural Sciences |
PURDUE UNIVERSITY35-6002041 | CHICAGO, IL | $637.8K | Cash | Research-Physics |
FLORIDA STATE UNIVERSITY59-1961248 | TALLAHASSEE, FL | $630.9K | Cash | Research |
ALBERT EINSTEIN COLLEGE OF MEDICINE13-1624225 | BRONX, NY | $606.2K | Cash | Research |
BROWN UNIVERSITY | PROVIDENCE, RI | $604.6K | Cash | Research |
PENNSYLVANIA STATE UNIVERSITY24-6000376 | HERSHEY, PA | $592.9K | Cash | Research |
OHIO STATE UNIVERSITY31-6025986 | COLUMBUS, OH | $566.4K | Cash | Research |
Wesleyan University | Middletown, CT | $554K | Cash | Research |
GEORGIA TECH RESEARCH CORP58-0603146 | ATLANTA, GA | $553.6K | Cash | Research |
Syracuse University15-0532081 | Syracuse, NY | $536.2K | Cash | Research |
BOSTON UNIVERSITY | Boston, MA | $532.2K | Cash | Research |
University of Miami59-0624458 | MIAMI, FL | $489.4K | Cash | Research-Biological & Biomedical Sciences |
State University of Iowa42-6004813 | Iowa City, IA | $488.3K | Cash | Research |
COLORADO STATE UNIVERSITY84-6000545 | FORT COLLINS, CO | $487.9K | Cash | Research |
UNIVERSITY OF COLORADO DENVER84-6000555 | DENVER, CO | $477.7K | Cash | Research |
GEORGE WASHINGTON UNIVERSITY53-0196584 | PHILADELPHIA, PA | $462.2K | Cash | Research |
California Institute of Technology95-1643307 | Pasadena, CA | $448.4K | Cash | Research |
Texas A & M University74-6000531 | College Station, TX | $448.2K | Cash | Research |
US Dept of Agriculture72-0564834 | Saint Louis, MO | $418.2K | Cash | Research |
EMORY UNIVERSITY58-0566256 | ATLANTA, GA | $405.8K | Cash | Research |
MASSACHUSETTS GENERAL HOSPITAL | BOSTON, MA | $398.3K | Cash | Research |
The Trustees of Princeton University21-0634501 | Princeton, NJ | $395.8K | Cash | Research |
UNIVERSITY OF SOUTHERN CALIFORNIA95-1642394 | LOS ANGELES, CA | $393.8K | Cash | Research |
VANDERBILT UNIVERSITY62-0476822 | NASHVILLE, TN | $383.1K | Cash | Research |
THE BOARD OF REGENTS UNIV OF NEBRASKA47-0049123 | LINCOLN, NE | $377K | Cash | Research |
Northeastern University | Boston, MA | $376.2K | Cash | Research-Physics |
HLEE MOFFITT CANCER CENTER &59-2451713 | ATLANTA, GA | $369.7K | Cash | Research |
Oregon State University61-1730890 | Corvallis, OR | $366.9K | Cash | Research |
OREGON HEALTH & SCIENCE UNIVERSITY93-1176109 | PORTLAND, OR | $360.4K | Cash | Research |
Rice University74-1109620 | Houston, TX | $355.4K | Cash | Research-Physics |
University of Rochester16-0743209 | Rochester, NY | $352.9K | Cash | Research |
Rochester Institute of Tech16-0743140 | Rochester, NY | $343K | Cash | Research |
University of Vermont & State Ag College | Burlington, VT | $335.9K | Cash | Research |
Battelle Memorial Institute31-4379427 | Columbus, OH | $330K | Cash | Research |
The University of Texas at Austin74-6000203 | Austin, TX | $314.5K | Cash | Research |
State of Colorado School of Mines84-6000551 | Golden, CO | $294K | Cash | Research |
University of Puerto Rico66-0560806 | Mayaguez, PR | $282K | Cash | Research |
INDIANA UNIVERSITY RESEARCH35-6001673 | INDIANAPOLIS, IN | $276.4K | Cash | Research |
George Mason University54-0836354 | Philadelphia, PA | $274.5K | Cash | Research |
University of Washington91-6001537 | Seattle, WA | $273.2K | Cash | Research |
New York Institute of Technology11-1788788 | Old Westbury, NY | $272.9K | Cash | Research |
Kansas State University48-0771751 | Manhattan, KS | $263K | Cash | Research |
University of Maine System | Portland, ME | $260.9K | Cash | Research-Agricultural Sciences |
Northern Illinois University36-6008480 | Dekalb, IL | $259.2K | Cash | Research |
Virginia Polytech Inst&State Univ54-6001805 | Blacksburg, VA | $257.9K | Cash | Research-Agricultural Sciences |
TEXAS A&M ENGINEERING EXPERIMENT ST74-1974733 | COLLEGE STATIN, TX | $257.3K | Cash | Research |
INSTITUTE FOR APPLIED GERONTOLOGY I11-3135751 | NEW YORK, NY | $255.2K | Cash | Research |
University of South Florida59-6001874 | Tampa, FL | $251.1K | Cash | Research-Civil Engineering |
Trustees of Dartmouth College | Hanover, NH | $236.8K | Cash | Research |
TEXAS A & M AGRILIFE RESEARCH74-6000541 | COLLEGE STATION, TX | $231.6K | Cash | Research |
LIFESPAN OF GREATER ROCHESTER INC16-0986298 | ROCHESTER, NY | $230.3K | Cash | Research |
Carnegie Mellon University25-0969449 | Pittsburgh, PA | $224.6K | Cash | Research |
Montana State University81-6010045 | Bozeman, MT | $220.6K | Cash | Research |
NYP CU WC INTERGRATED SERVICES LLC46-2875125 | NEW YORK, NY | $211.7K | Cash | Research |
JACKSON LAB | BAR HARBOR, ME | $207K | Cash | Research |
BROOKHAVEN SCIENCE ASSOCIATES LLC11-3403915 | UPTON, NY | $206.7K | Cash | Research |
WORCESTER POLYTECHNIC INSTITUTE | WORCESTER, MA | $205.9K | Cash | Research |
CHILDRENS HOSPITAL OF PHILADELPHIA23-1352166 | PHILADELPHIA, PA | $205.2K | Cash | Research |
Virginia Commonwealth University54-6001758 | Richmond, VA | $204.2K | Cash | Research |
TEMPLE UNIVERSITY23-1365971 | PHILADELPHIA, PA | $203.8K | Cash | Research |
UNIVERSITY OF TEXAS MD ANDERSON74-6001118 | HOUSTON, TX | $202.3K | Cash | Research |
Skyline Nav AI Inc85-2955757 | Cambridge, MA | $200K | Cash | Research |
Soctera Inc84-4363263 | Ithaca, NY | $200K | Cash | Research |
Beneficent Technology Inc77-0555413 | Palo Alto, CA | $197.8K | Cash | Research |
Health Research Inc14-1402155 | Buffalo, NY | $194K | Cash | Research-Biological & Biomedical Sciences |
FRED HUTCHINSON CANCER CENTER91-1935159 | SEATTLE, WA | $193.3K | Cash | Research |
Washington State University91-6001108 | Prosser, WA | $191K | Cash | Research |
Reaction Engineering International87-0474621 | Midvale, UT | $190.2K | Cash | Research |
Organic Robotics Corp83-2161768 | Ithaca, NY | $188.2K | Cash | Research |
Alliance for Sust Energy LLC26-1939342 | LKWood, CO | $185K | Cash | Research |
The University of Texas at El Paso74-6000813 | El Paso, TX | $184K | Cash | Research-Engineering |
UNIVERSITY OF UTAH87-6000525 | SALT LAKE CITY, UT | $173K | Cash | Research |
RECINTO DE CIENCIAS MEDICAS66-0433762 | SAN JUAN, PR | $172.8K | Cash | Research |
West Virginia Univ Research Corp55-0665758 | Morgantown, WV | $170.1K | Cash | Research |
HENRY M JACKSON FOUNDATION FOR THE52-1317896 | BETHESDA, MD | $166.6K | Cash | Research |
University Corp for Atmospheric Research84-0412668 | Boulder, CO | $161K | Cash | Research |
UNIV OF MISSOURI43-6003859 | Columbia, MO | $159.2K | Cash | Research |
ANN & ROBERT H LURIE36-2170833 | CHICAGO, IL | $155.1K | Cash | Research |
VAN ANDEL RESEARCH INSTITUTE52-2000823 | GRAND RAPIDS, MI | $148.8K | Cash | Research |
VMR Consulting Inc75-3196889 | Huntington Beach, CA | $143.5K | Cash | Research |
Climate Conservation27-1226829 | Bozeman, MT | $142.2K | Cash | Research |
The Catholic University of America53-0196583 | Washington, DC | $135.4K | Cash | Research |
New Markets Lab27-3977364 | Washington, DC | $135.2K | Cash | Research |
University Kansas Ctr for Research Inc48-0680117 | Lawrence, KS | $131.4K | Cash | Research |
SLOAN KETTERING CANCER CENTER13-1624182 | NEW YORK, NY | $130.8K | Cash | Research |
UT-Battelle LLC62-1788235 | Oak Ridge, TN | $125.2K | Cash | Research |
Cultural Practice LLC52-2236285 | Bethesda, MD | $118.7K | Cash | Research |
Conservation Metrics Inc45-5163605 | Santa Cruz, CA | $118.7K | Cash | Research |
Advanced Conservation Str20-4002778 | Williamsburg, VA | $117K | Cash | Research |
Connecticut Agricultural Experiment Sta | New Haven, CT | $117K | Cash | Research-Biological & Biomedical Sciences |
EVIDERA INC54-1759539 | BETHESDA, MD | $115.7K | Cash | Research |
| SAN ANTONIO, TX | $112.3K | Cash | Research | |
Paleontological Research Institution15-0554849 | Ithaca, NY | $111.5K | Cash | Research |
BLUE MARBLE SPACE27-0184094 | SEATTLE, WA | $109K | Cash | Research |
Intl Food Policy Research Institute52-1041632 | Washington, DC | $106.9K | Cash | Research-Health Sciences |
Ithaca College15-0532204 | Ithaca, NY | $105.9K | Cash | Other-Agricultural Sciences |
| Washington, DC | $105K | Cash | Research | |
AMERICAN CANCER SOCIETY13-1788491 | OKLAHOMA CITY, OK | $104.1K | Cash | Research |
University of New Mexico85-6000642 | Albuquerque, NM | $103.8K | Cash | Research-Physics |
NYS Coop Ext Assoc of Broome Cty16-6072872 | Binghamton, NY | $102.7K | Cash | Research |
MEDICAL COLLEGE OF WISCONSIN INC39-0806261 | MILWAUKEE, WI | $101.4K | Cash | Research |
VISITING NURSE SERVICE OF NY13-3189926 | NEW YORK, NY | $98.4K | Cash | Research |
University of Arkansas71-6003252 | Fayetteville, AR | $97.3K | Cash | Research |
| Ames, IA | $97K | Cash | Research | |
THIRD SECTOR NEW ENGLAND INC | BOSTON, MA | $95.1K | Cash | Research |
Planetary Science Institute33-0175263 | Tucson, AZ | $93.6K | Cash | Research |
J DAVID GLADSTONE INSTITUTES23-7203666 | SAN FRANCISCO, CA | $92.5K | Cash | Research |
Board of Trustees of Michigan State Univ38-6005984 | East Lansing, MI | $92.2K | Cash | Research-Agricultural Sciences |
University of Oklahoma73-6017987 | Norman, OK | $91.9K | Cash | Research |
GripTape Inc84-1835502 | New York, NY | $91.2K | Cash | Research |
HEALTH CORE51-0365660 | WILMINGTON, DE | $90.7K | Cash | Research |
Children's Research Institute47-0379754 | Silver Spring, MD | $89.1K | Cash | Research |
Centro Internacional de Agr Tropical Inc23-7187762 | Medlye, FL | $88.5K | Cash | Research-Agricultural Sciences |
Case Western Reserve University34-1018992 | Cleveland, OH | $88.4K | Cash | Research |
REGENTS OF THE UNIVERSITY OF SANTA CRUZ94-1539563 | SANTA CRUZ, CA | $85.9K | Cash | Research |
CINCINNATI CHILDRENS HOSPITAL31-0833936 | CINCINNATI, OH | $83.7K | Cash | Research |
Research Triangle Institute56-0686338 | Research Triangle Park, NC | $82.9K | Cash | Research |
Albert Einstein College of Medicine Inc47-2209056 | Bronx, NY | $81.1K | Cash | Research |
PULMONARY FIBROSIS FOUNDATION84-1558631 | CHICAGO, IL | $80.6K | Cash | Research |
THE BROAD INSTITUTE INC26-3428781 | CAMBRIDGE, MA | $80.1K | Cash | Research |
Bigelow Laboratory for Ocean Sciences | East Boothbay, ME | $79.3K | Cash | Research-Biological & Biomedical Sciences |
University of Wisconsin System39-1805963 | Madison, WI | $77.4K | Cash | Research |
The University of Alabama in Huntsville63-0520830 | Huntsville, AL | $76.5K | Cash | Research |
| Detroit, MI | $75.4K | Cash | Research | |
NATIONAL JEWISH HEALTH74-2044647 | DENVER, CO | $75.3K | Cash | Research |
Glynwood Center Inc13-3852957 | Cold Spring, NY | $72.7K | Cash | Research |
UNIVERSITY OF TEXAS AT SAN ANTONIO74-1717115 | SAN ANTONIO, TX | $72.2K | Cash | Research |
Arkansas State University71-6000556 | State University, AR | $71.9K | Cash | Research |
THE ROGOSIN INSTITUTE13-3184198 | NEW YORK, NY | $71.8K | Cash | Research |
VITALANT86-0098929 | PHOENIX, AZ | $71.2K | Cash | Research |
Cornell Coop Ext Suffolk Cty11-6081424 | Yaphank, NY | $69.1K | Cash | Other-Agricultural Sciences |
Resources for Independent Living94-2344976 | Pennsville, NJ | $69.1K | Cash | Research |
Brigham Young University87-0217280 | Provo, UT | $68.9K | Cash | Research-Physics |
Sciencenter Discovery Museum22-2470652 | Ithaca, NY | $68.8K | Cash | Research |
UNIVERSITY OF LOUISVILLE RESEARCH61-1029626 | LOUISVILLE, KY | $68.7K | Cash | Research |
University of Alaska92-6000147 | Fairbanks, AK | $67.5K | Cash | Research |
UNIVERSITY OF KANSAS MEDICAL CENTER48-1108830 | KANSAS CITY, KS | $67.5K | Cash | Research |
COLD SPRING HARBOR LABORATORY11-2013303 | COLD SPRING HARBOR, NY | $65.4K | Cash | Research |
FEINSTEIN INSTITUTE FOR MEDICAL RES11-2973595 | PHILADELPHIA, PA | $65.2K | Cash | Research |
Trustees of Tufts College | Boston, MA | $62.6K | Cash | Research-Other Physical Sciences |
UNIVERSITY OF HAWAII99-6000354 | HONOLULU, HI | $62.4K | Cash | Research-Agricultural Sciences |
Movimiento para el Alcance deVida Ind66-0446732 | San Juan, PR | $60.9K | Cash | Research |
| Kingston, NY | $60.6K | Cash | Research | |
CLINICAL DIRECTORS NETWORK INC14-1717344 | NEW YORK, NY | $58.4K | Cash | Research |
UNIVERSITY MEDICAL CENTER MANAGEMEN25-1925187 | NEW ORLEANS, LA | $58K | Cash | Research |
REEgen Inc88-2825057 | Ithaca, NY | $55K | Cash | Research |
Human Computation Institute81-5402321 | Ithaca, NY | $54.8K | Cash | Research |
NEW YORK METHODIST HOSPITAL11-1631796 | BROOKLYN, NY | $53.5K | Cash | Research |
Center for Transformative Action16-0990318 | Ithaca, NY | $51.5K | Cash | Research |
New England Aquarium Corporation | Boston, MA | $51.4K | Cash | Research-Biological & Biomedical Sciences |
Brigaid LLC83-0721610 | Middletown, CT | $51.2K | Cash | Research |
SWIM ACROSS AMERICA22-3248256 | Charlotte, NC | $50K | Cash | Community Sponsorship/Donation |
Mary Imogene Bassett Hospital13-5596796 | Cooperstown, NY | $47.5K | Cash | Research |
BAYLOR COLLEGE OF MEDICINE74-1613878 | HOUSTON, TX | $47.4K | Cash | Research |
CLEVELAND CLINIC FOUNDATION34-0714585 | CLEVELAND, OH | $47K | Cash | Research |
Mississippi State University64-6000819 | Mississippi State, MS | $45.9K | Cash | Research |
Space Science Institute84-1215290 | Boulder, CO | $45.6K | Cash | Research |
Institute for Systems Biology91-2003593 | Seattle, WA | $43.9K | Cash | Research |
METHODIST HOSPITAL87-0721923 | HOUSTON, TX | $43.9K | Cash | Research |
Virgin Islands Advocacy Incorporated66-0363251 | Frederiksted, VI | $43.4K | Cash | Research |
EpiBone Inc80-0952869 | Brooklyn, NY | $42.4K | Cash | Research |
SETI Institute94-2951356 | Mountain View, CA | $41.9K | Cash | Research |
| Baton Rouge, LA | $41.5K | Cash | Research | |
| Norfolk, VA | $41.4K | Cash | Research | |
HARVARD PILGRIM HEALTH CARE INC | BOSTON, MA | $41.3K | Cash | Research |
Beth Israel Deaconess Medical Ctr | Boston, MA | $40.7K | Cash | Research |
NEW YORK PRESBYTERIANQUEENS11-1839362 | FLUSHING, NY | $40K | Cash | Research |
VANDERBILT UNIVERSITY MEDICAL35-2528741 | NASHVILLE, TN | $39.9K | Cash | Research |
AguaClara Reach Inc82-2023059 | Ithaca, NY | $39.6K | Cash | Research |
WAKE FOREST UNIVERSITY BAPTIST51-0190238 | WINSTOSALEM, NC | $38.8K | Cash | Research |
Tuskegee University63-0288878 | Tuskegee, AL | $38.4K | Cash | Research |
Florida Atlantic University65-0385507 | Boca Raton, FL | $37.9K | Cash | Research |
Cornell Coop Ext Tompkins Cty16-6072897 | Ithaca, NY | $37.8K | Cash | Research |
HENRY FORD HEALTH SYSTEM38-1357020 | TROY, MI | $37.6K | Cash | Research |
Texas Tech University75-2668014 | Lubbock, TX | $36.3K | Cash | Research |
Cornell Coop Extension of Monroe County16-6072886 | Rochester, NY | $35.9K | Cash | Research |
MaineHealth | Westbrook, ME | $35.5K | Cash | Research |
UNIVERSITY OF CINCINNATI31-6000989 | CINCINNATI, OH | $34.9K | Cash | Research |
Smithsonian Institution53-0206027 | Washington, DC | $33.8K | Cash | Research-Astronomy & Astrophysics |
Cornell Coop Extension Assoc Essex14-6048677 | Lewis, NY | $33K | Cash | Research |
Goshen College35-2158366 | Goshen, IN | $32.6K | Cash | Research |
EAST CAROLINA UNIVERSITY56-6000403 | Greenville, NC | $32.4K | Cash | Research |
Somerset County Soil and Water Conservation | Skowhegan, ME | $32K | Cash | Research-Biological & Biomedical Sciences |
University of Tennessee62-6001636 | Knoxville, NY | $31.6K | Cash | Research |
INSTITUTE FOR CANCER RESEARCH23-6296135 | PHILADELPHIA, PA | $30K | Cash | Research |
Bradley University37-0861494 | Peoria, IL | $29.8K | Cash | Research-Biological & Biomedical Sciences |
LOUISIANA PUBLIC HEALTH INSTITUTE72-1379921 | NEW ORLEANS, LA | $29.5K | Cash | Research |
1199 Seiu Home Care Ind71-1028611 | NEW YORK, NY | $26.6K | Cash | Research |
University of North Texas75-6002149 | Denton, TX | $26.5K | Cash | Research |
PrisAM LLC84-4840892 | Rochester, NY | $25K | Cash | Research |
Cornell Coop Ext of Saratoga Cty14-6036892 | Ballston Spa, NY | $25K | Cash | Research |
Datalytica LLC83-0933023 | Laurel, MD | $25K | Cash | Research |
AVS US Inc34-2012599 | Lansing, NY | $25K | Cash | Research |
Cornell Coop Ext of Steuben Cty16-6072895 | Bath, NY | $24.9K | Cash | Research |
Board Trustees Southern Illinois Univ37-6005961 | Carbondale, IL | $24.6K | Cash | Research |
Florida Institute of Technology Inc59-6046500 | Melbourne, FL | $24.4K | Cash | Research |
MAYO CLINIC41-6011702 | MINNEAPOLIS, MN | $24.1K | Cash | Research |
Blue Marble Space | Seattle, WA | $23.9K | Cash | Research-Astronomy & Astrophysics |
Donald Danforth Plant Science Center31-1584621 | Saint Louis, MO | $23.7K | Cash | Research |
Regents of the University of Idaho82-6000945 | Parma, ID | $23.3K | Cash | Research-Astronomy & Astrophysics |
END DOMESTIC ABUSE WISCONSIN39-1380437 | MADISON, WI | $23.3K | Cash | Research |
North Dakota State University45-6002439 | Fargo, ND | $23.2K | Cash | Research |
Manpower Demonstration Research Corp23-7379473 | New York, NY | $22.9K | Cash | Research |
Rooted WI Inc39-1854762 | Madison, WI | $22.6K | Cash | Research |
Stockholm Environment Institute US Inc20-4659308 | Somerville, MA | $22.1K | Cash | Research |
Lehigh University24-0795445 | Bethlehem, PA | $21.1K | Cash | Research |
The Land Institute48-0842156 | Salina, KS | $21K | Cash | Research |
RED WIND CONSULTING INC20-3369356 | COLORADO SPRINGS, CO | $20.5K | Cash | Research |
The New School13-3297197 | New York, NY | $20K | Cash | Research |
AMERICAN AUSTRIAN FOUND13-3275103 | NEW YORK, NY | $20K | Cash | Comm Sponsorship/Donation |
Pratt Institute11-1630822 | Brooklyn, NY | $20K | Cash | Research |
CLEVELAND STATE UNIVERSITY34-0966056 | CLEVELAND, OH | $19.6K | Cash | Research |
United States Geological Survey53-0196958 | Laurel, MD | $19.5K | Cash | Research |
OCHSNER CLINIC FOUNDATION72-0502505 | NEW ORLEANS, LA | $19.3K | Cash | Research |
SPAULDING REHABILITATION HOSPITAL C | SOMERVILLE, MA | $19.2K | Cash | Research |
Lautec US Inc38-4102913 | Boston, MA | $18.9K | Cash | Research |
University of Rhode Island22-3011455 | Kingston, RI | $18.9K | Cash | Research-Agricultural Sciences |
Trustees of Union College14-1338580 | Schenectady, NY | $18.3K | Cash | Research-Mechanical Engineering |
Barnard College13-1628149 | New York, NY | $18K | Cash | Research |
Auburn University63-6000724 | Auburn University, AL | $17.9K | Cash | Research |
| Rye Brook, NY | $17.5K | Cash | Community Sponsorship/Donation | |
Cornell Co-Op Ext of St Lawrence Cty14-6037202 | Canton, NY | $16.4K | Cash | Research |
Rensselaer Polytechnic Institute14-1340095 | Troy, NY | $15.3K | Cash | Research-Mechanical Engineering |
| Yakima, WA | $15.1K | Cash | Research | |
LEUKEMIA AND LYMPHOMA SOCIETY INC13-5644916 | NEW YORK, NY | $15K | Cash | Membership |
International Community Foundation33-0457858 | National City, CA | $15K | Cash | Research |
DARTMOUTH HITCHCOCK MEDICAL CENTER22-2715483 | LEBANON, NH | $14.9K | Cash | Research |
Delaware State University51-0305893 | Dover, DE | $14.7K | Cash | Research |
RESEARCH FOUNDATION FOR MENTAL14-1410842 | MENANDS, NY | $14.2K | Cash | Research |
Skidmore College14-1338562 | Satatoga Springs, NY | $14.1K | Cash | Research |
FRONTIER SCIENCE & TECHNOLOGY16-1056814 | BOSTON, MA | $14K | Cash | Research |
Benaroya Research Institute at91-0653422 | Seattle, WA | $13.5K | Cash | Research |
CATHOLIC MANAGED LONG TERM CARE20-8180809 | NEW YORK, NY | $13.2K | Cash | Research |
Windsor Central School District15-6002440 | Windsor, NY | $12.8K | Cash | Research |
Cornell Coop Ext of Jefferson Cty16-6072882 | Watertown, NY | $12.2K | Cash | Other-Psychology |
B&D Engineering and Consulting LLC46-5624420 | Lander, WY | $12.2K | Cash | Research |
University of Mississippi64-6001159 | University, MS | $12.1K | Cash | Research |
DisabilityIN26-0482057 | Alexandria, VA | $11.5K | Cash | Research |
Global Philanthropy Partnership56-2342600 | Chicago, IL | $11.5K | Cash | Research |
Cornell Coop Ext of Erie Cty16-6072879 | East Aurora, NY | $11.3K | Cash | Research |
iFood Decision Sciences Inc47-5657549 | Kenmore, WA | $10.8K | Cash | Research |
Maine Organic Farmers & Gardeners | Unity, ME | $10.6K | Cash | Research |
FRIENDS RESEARCH INSTITUTE52-0701445 | BALTIMORE, MD | $10.4K | Cash | Research |
THE CHARLOTTE-MECHLENBURG HOSPITAL56-0529945 | CHARLOTTE, NC | $10.4K | Cash | Research |
ALLIANCE MFG&TECH STHERN TIER16-1340290 | Binghamt, NY | $10.3K | Cash | Research |
Binghamton City School District15-6002134 | Binghamton, NY | $10.2K | Cash | Research |
CHILDRENS RESEARCH INSTITUTE52-1654453 | SILVER SPRING, MD | $10.1K | Cash | Research |
AMERICAN HOSPITAL OF PARIS54-1031618 | NEW YORK, NY | $10K | Cash | Comm Sponsorship/Donation |
PANCREATIC CANCER ACTION NETWORK33-0841281 | Manhattan Beach, CA | $10K | Cash | Community Sponsorship/Donation |
| Columbia, MD | $10K | Cash | Community Sponsorship/Donation | |
BOSTON COLLEGE | CHESTNUT HILL, MA | $9,711 | Cash | Research |
Colorado Seminary84-1512831 | Denver, CO | $9,608 | Cash | Research |
RESEARCH AMERICA52-1609875 | Arlington, VA | $8,600 | Cash | Membership |
EMPIRICAN PRN INC81-2538163 | BUFFALO, NY | $8,580 | Cash | Research |
The Village at Ithaca Inc16-1554144 | Ithaca, NY | $8,400 | Cash | Research |
Ithaca Health Alliance Inc90-0192978 | Ithaca, NY | $8,400 | Cash | Research |
Colgate University15-0532078 | Hamilton, NY | $8,262 | Cash | Research |
COOK CHILDRENS HEALTH CARE SYSTEM75-2705881 | FORT WORTH, TX | $8,000 | Cash | Research |
SEATTLE CHILDRENS HOSPITAL91-0564748 | SEATTLE, WA | $8,000 | Cash | Research |
University System of New Hampshire Inc | Concord, NH | $7,999 | Cash | Research-Agricultural Sciences |
Cornell Coop Ext of Sullivan County14-6036894 | Liberty, NY | $7,756 | Cash | Research |
UNITED HOSPITAL FUND OF NEW YORK13-1562656 | NEW YORK, NY | $7,500 | Cash | Community Sponsorship/Donation |
Kean University22-2960726 | Union, NJ | $7,416 | Cash | Research |
| DALLAS, TX | $7,374 | Cash | Research | |
The Piedmont Environmental Council54-0935569 | Warrenton, VA | $7,125 | Cash | Research |
FRIENDS OF ST CATHERINE PARK13-3955098 | NEW YORK, NY | $7,000 | Cash | Community Sponsorship/Donation |
BRIGHAM AND WOMENS PHYSICIANS | BOSTON, MA | $7,000 | Cash | Research |
WESTERN INSTITUTE FOR VETERANS RESE87-0470748 | SALT LAKE CITY, UT | $6,861 | Cash | Research |
Intrepid Museum Foundation Inc13-3062419 | New York, NY | $6,850 | Cash | Research-Mechanical Engineering |
LA NET COMMUNITY HEALTH RESOURCE NE45-4682159 | PICO RIVERA, CA | $6,600 | Cash | Research |
Lithoz America LLC82-0879276 | Troy, NY | $6,400 | Cash | Research |
Alfred University16-0743900 | Alfred, NY | $6,269 | Cash | Research |
HARVEY SOCIETY13-6165708 | NEW YORK, NY | $6,000 | Cash | Membership |
Welfare Research Inc14-6046778 | Albany, NY | $5,708 | Cash | Research |
SUNY Broome Community College16-1393336 | Binghamton, NY | $5,469 | Cash | Research |
BRANDEIS UNIVERSITY | WALTHAM, MA | $5,037 | Cash | Research |
| Total | $120.8M | |||
NEW YORK, NY
$6.2M
CHICAGO, IL
$4.1M
NEW YORK, NY
$3.8M
CHICAGO, IL
$3.4M
UNIVERSITY OF MASSACHUSETTS
WORCESTER, MA
$2.9M
BRIGHAM & WOMENS HOSPITAL INC
BOSTON, MA
$2.8M
LOS ANGELES, CA
$2.7M
LOS ANGELES, CA
$2.4M
PISCATAWAY, NJ
$2.4M
Gainesville, FL
$2.3M
Stanford, CA
$2.2M
CHARLOTTE, NC
$2.1M
YALE UNIVERSITY GRANTS AND CONTRACT
NEW HAVEN, CT
$2.1M
Notre Dame, IN
$2M
HARVARD UNIVERSITY
CAMBRIDGE, MA
$1.9M
ALBANY, NY
$1.8M
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
CAMBRIDGE, MA
$1.8M
Ann Arbor, MI
$1.8M
Pittsburgh, PA
$1.6M
Madison, WI
$1.6M
CHARLOTTESVILLE, VA
$1.5M
NEW YORK, NY
$1.4M
NUTLEY, NJ
$1.4M
New York, NY
$1.4M
BIRMINGHAM, AL
$1.4M
Merced, CA
$1.3M
NEW ORLEANS, LA
$1.2M
NEW YORK, NY
$1.1M
Quincy, MA
$1.1M
CHAPEL HILL, NC
$1.1M
MINNEAPOLIS, MN
$1M
Ithaca, NY
$1M
SEATTLE, WA
$1M
Santa Barbara, CA
$1M
BOSTON MEDICAL CENTER CORPORATION
BOSTON, MA
$996.9K
Baltimore, MD
$991.4K
CHICAGO, IL
$991.4K
NEW YORK, NY
$981.8K
NEW YORK, NY
$966.5K
DALLAS, TX
$885.7K
$867.9K
Bethesda, MD
$858.1K
TEMPE, AZ
$857.6K
ST LOUIS, MO
$838.8K
EVANSTON, IL
$831.8K
PHILADELPHIA, PA
$798.7K
BOSTON CHILDRENS HOSPITAL
BOSTON, MA
$789.3K
REGENTS OF THE UCLA DAVIS
LOS ANGELES, CA
$787.7K
MEMPHIS, TN
$762K
Tucson, AZ
$741.9K
LOS ANGELES, CA
$724.9K
Raleigh, NC
$715.3K
DANA FARBER CANCER INSTITUTE
BOSTON, MA
$710.5K
NEW YORK, NY
$702.4K
LOS ANGELES, CA
$677.4K
Clemson, SC
$650.1K
CHICAGO, IL
$637.8K
TALLAHASSEE, FL
$630.9K
BRONX, NY
$606.2K
BROWN UNIVERSITY
PROVIDENCE, RI
$604.6K
HERSHEY, PA
$592.9K
COLUMBUS, OH
$566.4K
Wesleyan University
Middletown, CT
$554K
ATLANTA, GA
$553.6K
Syracuse, NY
$536.2K
BOSTON UNIVERSITY
Boston, MA
$532.2K
MIAMI, FL
$489.4K
Iowa City, IA
$488.3K
FORT COLLINS, CO
$487.9K
DENVER, CO
$477.7K
PHILADELPHIA, PA
$462.2K
Pasadena, CA
$448.4K
College Station, TX
$448.2K
Saint Louis, MO
$418.2K
ATLANTA, GA
$405.8K
MASSACHUSETTS GENERAL HOSPITAL
BOSTON, MA
$398.3K
Princeton, NJ
$395.8K
LOS ANGELES, CA
$393.8K
NASHVILLE, TN
$383.1K
LINCOLN, NE
$377K
Northeastern University
Boston, MA
$376.2K
ATLANTA, GA
$369.7K
Corvallis, OR
$366.9K
PORTLAND, OR
$360.4K
Houston, TX
$355.4K
Rochester, NY
$352.9K
Rochester, NY
$343K
University of Vermont & State Ag College
Burlington, VT
$335.9K
Columbus, OH
$330K
Austin, TX
$314.5K
Golden, CO
$294K
Mayaguez, PR
$282K
INDIANAPOLIS, IN
$276.4K
Philadelphia, PA
$274.5K
Seattle, WA
$273.2K
Old Westbury, NY
$272.9K
Manhattan, KS
$263K
University of Maine System
Portland, ME
$260.9K
Dekalb, IL
$259.2K
Blacksburg, VA
$257.9K
COLLEGE STATIN, TX
$257.3K
NEW YORK, NY
$255.2K
Tampa, FL
$251.1K
Trustees of Dartmouth College
Hanover, NH
$236.8K
COLLEGE STATION, TX
$231.6K
ROCHESTER, NY
$230.3K
Pittsburgh, PA
$224.6K
Bozeman, MT
$220.6K
NEW YORK, NY
$211.7K
JACKSON LAB
BAR HARBOR, ME
$207K
UPTON, NY
$206.7K
WORCESTER POLYTECHNIC INSTITUTE
WORCESTER, MA
$205.9K
PHILADELPHIA, PA
$205.2K
Richmond, VA
$204.2K
PHILADELPHIA, PA
$203.8K
HOUSTON, TX
$202.3K
Cambridge, MA
$200K
Ithaca, NY
$200K
Palo Alto, CA
$197.8K
Buffalo, NY
$194K
SEATTLE, WA
$193.3K
Prosser, WA
$191K
Midvale, UT
$190.2K
Ithaca, NY
$188.2K
LKWood, CO
$185K
El Paso, TX
$184K
SALT LAKE CITY, UT
$173K
SAN JUAN, PR
$172.8K
Morgantown, WV
$170.1K
BETHESDA, MD
$166.6K
Boulder, CO
$161K
Columbia, MO
$159.2K
CHICAGO, IL
$155.1K
GRAND RAPIDS, MI
$148.8K
Huntington Beach, CA
$143.5K
Bozeman, MT
$142.2K
Washington, DC
$135.4K
Washington, DC
$135.2K
Lawrence, KS
$131.4K
NEW YORK, NY
$130.8K
Oak Ridge, TN
$125.2K
Bethesda, MD
$118.7K
Santa Cruz, CA
$118.7K
Williamsburg, VA
$117K
Connecticut Agricultural Experiment Sta
New Haven, CT
$117K
BETHESDA, MD
$115.7K
SAN ANTONIO, TX
$112.3K
Ithaca, NY
$111.5K
SEATTLE, WA
$109K
Washington, DC
$106.9K
Ithaca, NY
$105.9K
Washington, DC
$105K
OKLAHOMA CITY, OK
$104.1K
Albuquerque, NM
$103.8K
Binghamton, NY
$102.7K
MILWAUKEE, WI
$101.4K
NEW YORK, NY
$98.4K
Fayetteville, AR
$97.3K
$97K
THIRD SECTOR NEW ENGLAND INC
BOSTON, MA
$95.1K
Tucson, AZ
$93.6K
SAN FRANCISCO, CA
$92.5K
East Lansing, MI
$92.2K
Norman, OK
$91.9K
New York, NY
$91.2K
WILMINGTON, DE
$90.7K
Silver Spring, MD
$89.1K
Medlye, FL
$88.5K
Cleveland, OH
$88.4K
SANTA CRUZ, CA
$85.9K
CINCINNATI, OH
$83.7K
Research Triangle Park, NC
$82.9K
$81.1K
CHICAGO, IL
$80.6K
CAMBRIDGE, MA
$80.1K
Bigelow Laboratory for Ocean Sciences
East Boothbay, ME
$79.3K
Madison, WI
$77.4K
Huntsville, AL
$76.5K
Detroit, MI
$75.4K
DENVER, CO
$75.3K
Cold Spring, NY
$72.7K
SAN ANTONIO, TX
$72.2K
State University, AR
$71.9K
NEW YORK, NY
$71.8K
PHOENIX, AZ
$71.2K
Yaphank, NY
$69.1K
Pennsville, NJ
$69.1K
Provo, UT
$68.9K
Ithaca, NY
$68.8K
LOUISVILLE, KY
$68.7K
Fairbanks, AK
$67.5K
KANSAS CITY, KS
$67.5K
COLD SPRING HARBOR, NY
$65.4K
PHILADELPHIA, PA
$65.2K
Trustees of Tufts College
Boston, MA
$62.6K
HONOLULU, HI
$62.4K
San Juan, PR
$60.9K
Kingston, NY
$60.6K
NEW YORK, NY
$58.4K
NEW ORLEANS, LA
$58K
Ithaca, NY
$55K
Ithaca, NY
$54.8K
BROOKLYN, NY
$53.5K
Ithaca, NY
$51.5K
New England Aquarium Corporation
Boston, MA
$51.4K
Middletown, CT
$51.2K
Charlotte, NC
$50K
Cooperstown, NY
$47.5K
HOUSTON, TX
$47.4K
CLEVELAND, OH
$47K
Mississippi State, MS
$45.9K
Boulder, CO
$45.6K
Seattle, WA
$43.9K
HOUSTON, TX
$43.9K
Frederiksted, VI
$43.4K
Brooklyn, NY
$42.4K
Mountain View, CA
$41.9K
Baton Rouge, LA
$41.5K
Norfolk, VA
$41.4K
HARVARD PILGRIM HEALTH CARE INC
BOSTON, MA
$41.3K
Beth Israel Deaconess Medical Ctr
Boston, MA
$40.7K
FLUSHING, NY
$40K
NASHVILLE, TN
$39.9K
Ithaca, NY
$39.6K
WINSTOSALEM, NC
$38.8K
Tuskegee, AL
$38.4K
Boca Raton, FL
$37.9K
Ithaca, NY
$37.8K
TROY, MI
$37.6K
Lubbock, TX
$36.3K
Rochester, NY
$35.9K
MaineHealth
Westbrook, ME
$35.5K
CINCINNATI, OH
$34.9K
Washington, DC
$33.8K
Lewis, NY
$33K
Goshen, IN
$32.6K
Greenville, NC
$32.4K
Somerset County Soil and Water Conservation
Skowhegan, ME
$32K
Knoxville, NY
$31.6K
PHILADELPHIA, PA
$30K
Peoria, IL
$29.8K
NEW ORLEANS, LA
$29.5K
NEW YORK, NY
$26.6K
Denton, TX
$26.5K
Rochester, NY
$25K
Ballston Spa, NY
$25K
Laurel, MD
$25K
Lansing, NY
$25K
Bath, NY
$24.9K
Carbondale, IL
$24.6K
Melbourne, FL
$24.4K
MINNEAPOLIS, MN
$24.1K
Blue Marble Space
Seattle, WA
$23.9K
Saint Louis, MO
$23.7K
Parma, ID
$23.3K
MADISON, WI
$23.3K
Fargo, ND
$23.2K
New York, NY
$22.9K
Madison, WI
$22.6K
Somerville, MA
$22.1K
Bethlehem, PA
$21.1K
Salina, KS
$21K
COLORADO SPRINGS, CO
$20.5K
New York, NY
$20K
NEW YORK, NY
$20K
Brooklyn, NY
$20K
CLEVELAND, OH
$19.6K
Laurel, MD
$19.5K
NEW ORLEANS, LA
$19.3K
SPAULDING REHABILITATION HOSPITAL C
SOMERVILLE, MA
$19.2K
Boston, MA
$18.9K
Kingston, RI
$18.9K
Schenectady, NY
$18.3K
New York, NY
$18K
Auburn University, AL
$17.9K
Rye Brook, NY
$17.5K
Canton, NY
$16.4K
Troy, NY
$15.3K
$15.1K
NEW YORK, NY
$15K
National City, CA
$15K
LEBANON, NH
$14.9K
Dover, DE
$14.7K
MENANDS, NY
$14.2K
Satatoga Springs, NY
$14.1K
BOSTON, MA
$14K
Seattle, WA
$13.5K
NEW YORK, NY
$13.2K
Windsor, NY
$12.8K
Watertown, NY
$12.2K
Lander, WY
$12.2K
University, MS
$12.1K
Alexandria, VA
$11.5K
Chicago, IL
$11.5K
East Aurora, NY
$11.3K
Kenmore, WA
$10.8K
Maine Organic Farmers & Gardeners
Unity, ME
$10.6K
BALTIMORE, MD
$10.4K
CHARLOTTE, NC
$10.4K
Binghamt, NY
$10.3K
Binghamton, NY
$10.2K
SILVER SPRING, MD
$10.1K
NEW YORK, NY
$10K
Manhattan Beach, CA
$10K
Columbia, MD
$10K
BOSTON COLLEGE
CHESTNUT HILL, MA
$9,711
Denver, CO
$9,608
Arlington, VA
$8,600
BUFFALO, NY
$8,580
Ithaca, NY
$8,400
Ithaca, NY
$8,400
Hamilton, NY
$8,262
FORT WORTH, TX
$8,000
SEATTLE, WA
$8,000
University System of New Hampshire Inc
Concord, NH
$7,999
Liberty, NY
$7,756
NEW YORK, NY
$7,500
Union, NJ
$7,416
$7,374
Warrenton, VA
$7,125
NEW YORK, NY
$7,000
BRIGHAM AND WOMENS PHYSICIANS
BOSTON, MA
$7,000
SALT LAKE CITY, UT
$6,861
New York, NY
$6,850
PICO RIVERA, CA
$6,600
Troy, NY
$6,400
Alfred, NY
$6,269
NEW YORK, NY
$6,000
Albany, NY
$5,708
Binghamton, NY
$5,469
BRANDEIS UNIVERSITY
WALTHAM, MA
$5,037
Source: USAspending.gov · Searched by organization name
VA/DoD Awards
$166.9M
VA/DoD Award Count
14
Funding from the Department of Veterans Affairs and/or Department of Defense.
Total Federal Funding (partial)
$3.2B
Awards Found
200+
Additional awards may exist. View all on USAspending.gov →
National Science Foundation
$137.9M
NNIN: NATIONAL NANOTECHNOLOGY INFRASTRUCTURE NETWORK
National Science Foundation
$106M
OPERATION OF CORNELL HIGH ENERGY SYNCHROTRON SOURCE (CHESS)
National Science Foundation
$79.4M
U.S. CMS UPGRADES FOR THE HIGH-LUMINOSITY LARGE HADRON COLLIDER
Department of Health and Human Services
$76.4M
CLINICAL AND TRANSLATIONAL SCIENCE CENTER
National Science Foundation
$74.9M
OPERATION OF THE CORNELL HIGH ENERGY SYNCHROTRON SOURCE (CHESS)
National Science Foundation
$59M
OPERATION OF THE NSF CENTER FOR HIGH ENERGY X-RAY SCIENCE (NSF-CHEXS)
Department of Health and Human Services
$48.2M
TRI-INSTITUTIONAL TB RESEARCH UNIT: PERSISTENCE AND LATENCY
National Science Foundation
$47.7M
AST COOPERATIVE SUPPORT AGREEMENT PY 2006
Department of Health and Human Services
$44.6M
CORNELL CLINICAL TRIALS UNIT
Department of Health and Human Services
$42.8M
CLINICAL AND TRANSLATIONAL SCIENCE CENTER
National Science Foundation
$42.1M
GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)
Department of Health and Human Services
$41.4M
CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)
National Science Foundation
$40.1M
SUPPORT OF THE CORNELL ELECTRON STORAGE RING (CESR) FACILITY
Department of Health and Human Services
$35.4M
CLEAVED, STABILIZED HIV-1 ENV TRIMERS FOR STRUCTURAL AND VACCINE STUDIES
Department of Education
$35.1M
CORNELL UNIVERSITY CARES ACT REQUEST - INSTITUTIONAL PORTION
Department of Energy
$34.6M
TAS::89 0227::TAS RECOVERY; RECOVERY ACT - NANOSTRUCTURED INTERFACES FOR ENERGY GENERATION, CONVERSION, AND STORAGE -- EFRC; PI - HECTOR ABRUNA
National Science Foundation
$34.6M
GRADUATE RESERACH FELLOWSHIP PROGRAM (GRFP)
Department of Health and Human Services
$34M
WEILL CORNELL/ROCKEFELLER/SLOAN-KETTERING MST PROGRAM
National Science Foundation
$32.7M
MID-SCALE RI-2: A FIRST-OF-ITS-KIND X-RAY FACILITY FOR NEW SCIENCE AT THE HIGH MAGNETIC FIELD FRONTIER
Department of Defense
$31.9M
THIS COOPERATIVE AGREEMENT SHALL BE PERFORMED IN ACCORDANCE WITH THE STATEMENT OF WORK (SOW) ENTITLED , "THE MATERIALS SOLUTIONS NETWORK AT CORNELL HI
Department of Health and Human Services
$31.2M
NE-CAT: A RESOURCE FOR ADVANCED MACROMOLECULAR CRYSTALLOGRAPHY
National Science Foundation
$31.1M
GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)
National Science Foundation
$31M
MID-SCALE: OPERATIONS OF THE CENTER FOR HIGH ENERGY X-RAY SCIENCE (CHEXS) -THIS AWARD CONTINUES TO SUPPORT OPERATIONS OF THE CENTER FOR HIGH ENERGY X-RAY SCIENCE (CHEXS), A NATIONAL FACILITY PROVIDING ACCESS TO UNIQUE, WORLD-LEADING EXPERIMENTAL CAPABILITIES FOR THE US AND INTER-NATIONAL RESEARCH COMMUNITY. CHEXS CONSISTS OF FOUR CORE RESEARCH EFFORTS, EACH ATTACHED TO SPECIFIC SYNCHROTRON BEAMLINES AT THE CORNELL HIGH ENERGY SYNCHROTRON SOURCE (CHESS). THESE RESEARCH PRO-GRAMS ALIGN WITH THE GOALS OF THE THREE NSF DIRECTORATES (BIO, ENG, AND MPS) WHICH HAVE SUPPORTED CHEXS SINCE 2019. RESEARCH AT ALL BEAMLINES IS FUNDAMENTALLY INTERDISCIPLINARY, AND PROPOSALS FROM ANY FIELD OF SCIENCE ARE ELIGIBLE FOR BEAMTIME, SUBJECT ONLY TO EXTERNAL PEER REVIEW BASES ON THE NSF REVIEW CRITERIA (SCIENTIFIC MERIT AND BROADER IMPACTS). CHEXS ALSO SUPPORTS EFFORTS IN X-RAY TECHNOLOGY R&D, EDUCATION OF THE NEXT GENERATION OF X-RAY EXPERTS, AND DEVELOPMENT AND INTEGRATION OF ADVANCED COMPUTATION AND DATA SCIENCE FOR SYNCHROTRONS. CHEXS HAS AN OVERARCHING MISSION TO BROADEN PARTICIPATION IN SYNCHROTRON RESEARCH, AND TO RECRUIT AND TRAIN A DIVERSE AND GROWING USER COMMUNITY. LOCATED ON THE CENTRAL CAMPUS OF CORNELL UNIVERSITY, CHEXS IS UNIQUELY ABLE TO TRAIN THE NEXT GENERATION OF SYNCHROTRON SCIENTISTS. CHEXS SUPPORTS POST-DOCS AND PH.D. STUDENTS, HOSTS HANDS-ON SCIENTIFIC WORKSHOPS TO TRAIN NEW USERS IN X-RAY METHODS, PROVIDES SUMMER TRAINING AND MENTORSHIP PROGRAMS TARGETING UNDERGRADUATES FROM UNDERREPRESENTED GROUPS IN STEM FIELDS, AND PROVIDES HIGH QUALITY IN-FORMATIONAL MATERIALS TO THE GENERAL PUBLIC. SPECIFIC RESEARCH AREAS TARGETED AT THE CENTER FOR HIGH ENERGY X-RAY SCIENCE (CHEXS) ARE: (1) TIME-RESOLVED STUDIES OF MANUFACTURING PROCESSES OF STRUCTURAL METALS; (2) STRUCTURAL STUDIES OF BIOMOLE-CULES IN EXTREME ENVIRONMENTS TO ELUCIDATE THE RULES OF LIFE; (3) HIGH-THROUGHPUT CHARACTERIZATION OF QUANTUM MATERIALS TO UNCOVER INTERTWINED QUANTUM CORRELATIONS; AND (4) SPECTROSCOPIC STUDIES OF VA-LENCE ELECTRONIC STATES IN FUNCTIONAL MATERIALS AND INSIDE OPERATING DEVICES. THE CHEXS TAKES ADVANTAGE OF THE HIGH BEAM ENERGY AND LARGE BUNCH CHARGES AVAILABLE FROM THE CORNELL ENERGY STORAGE RING (CESR) TO OFFER EXCITING OPPORTUNITIES FOR NANOSECOND-SCALE MEASUREMENTS OF DYNAMICS INSIDE HEAVY MATERIALS. CHEXS BEAMLINES ARE HARNESSING THE OPPORTUNITY PRESENTED BY RAPIDLY GROWING DATA COLLEC-TION RATES, INCORPORATING NEW ANALYSIS METHODS, DATA ANALYTICS AND MACHINE LEARNING. DEVELOPMENT OF FRONTIER RESEARCH AT CHEXS IS SUPPORTED BY AN X-RAY TECHNOLOGY R&D PROGRAM ON NEXT GENERATION, COST-EFFECTIVE, HIGH-PERFORMANCE UNDULATOR SOURCES, HIGH-HEAT-LOAD CRYSTAL OPTICS, FASTER X-RAY DETEC-TORS, AND BEAMLINE AUTOMATION. THE SPECIFIC X-RAY BEAMLINES INCLUDE: FORMING AND SHAPING TECHNOLOGY (FAST) BEAMLINE SUPPORTS SUB-MILLISECOND TIME-RESOLVED STUDIES OF MANUFACTURING PROCESSES SUCH AS LASER WELDING AND RAPID QUENCHING. EXTREME BIOLOGY (XBIO) BEAMLINES STUDIES THE BUILDING BLOCKS OF LIFE AT THE MOLECULAR LEVEL, UNDER EXTREME CONDITIONS SUCH AS HIGH PRESSURE, STRICT ANOXIC CONDITIONS, DISSOLVED GASSES, EXTREMES OF HEAT AND COLD, AND HARSH CHEMICAL ENVIRONMENTS. XBIO COMBINES BOTH CRYSTALLOGRAPHY AND SMALL ANGLE SCATTERING TO DETERMINE THE ATOMIC STRUCTURE, SHAPE, FOLDING AND OLIGOMERIC STATE OF MOLECULES. Q-MAPPING FOR QUANTUM MATERIALS (QM2) BEAMLINE PROVIDES HIGH-THROUGHPUT CHARACTERIZATION OF QUANTUM MATERIALS IN RECIPROCAL SPACE (ALSO KNOWN AS ?Q-SPACE?) TO UNCOVER INTERTWINED QUANTUM CORRELATIONS OF SPINS, CHARGES, AND ORBITALS, FROM HIGH TO LOW TEMPERATURES AND SPANNING ENTIRE PHASE DIAGRAMS. PHOTON-IN, PHOTON-OUT X-RAY SPECTROSCOPY (PIPOXS) BEAMLINE ENABLES SPECTROSCOPIC STUDIES OF VALENCE ELECTRONIC STATES IN FUNCTIONAL MATERIALS USING HARD X-RAYS, ALLOWING ACCESS TO OPAQUE MATERIALS OR SAMPLE ENVIRONMENTS. THE BEAMLINE SUPPORTS IN SITU AND OPERANDO STUDIES OF MAN-MADE CATALYSTS AND ENZYMES WITH APPLICATIONS TO FUEL-CELLS, BATTERIES, AND ELECTRONIC EXCITATIONS IN QUANTUM MATERIALS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.
National Science Foundation
$30.9M
IMR: PHASE IB ENERGY RECOVERY LINAC (ERL) TECHNOLOGY R&D
Department of Defense
$28.5M
ENHANCING EXPOSURE THERAPY FOR PTSD: VIRTUAL REALITY AND IMAGINAL EXPOSURE WITH A COGNITIVE ENHANCER
Department of Health and Human Services
$27.9M
BELIEVE: BENCH TO BED ENHANCED LYMPHOCYTE INFUSIONS TO ENGINEER VIRAL ERADICATION
National Science Foundation
$27.8M
MIP: PLATFORM FOR THE ACCELERATED REALIZATION, ANALYSIS, AND DISCOVERY OF INTERFACE MATERIALS (PARADIM)
Department of Health and Human Services
$27.5M
REACH: RESEARCH ENTERPRISE TO ADVANCE A CURE FOR HIV - PROJECT SUMMARY/ABSTRACT DESPITE THE SUCCESS OF STANDARD ANTIRETROVIRAL THERAPY (ART), THE NEED FOR AN HIV CURE REMAINS COMPELLING, BOTH TO IMPROVE THE LIVES OF PWH AND TO BRING ABOUT THE END OF THE PANDEMIC. STRATEGIES FOR AN HIV CURE FALL UNDER TWO CATEGORIES: THOSE THAT SEEK ART-FREE ‘REMISSION’, AND THOSE TARGETING A CLASSICAL CURE OR ‘ERADICATION’. WHILE PRECEDENTS EXIST FOR BOTH SCENARIOS, THE LATTER HAVE ONLY BEEN ACHIEVED WITH BONE MARROW TRANSPLANTATION. IN CONTRAST, ALTHOUGH NATURALLY OCCURRING IMMUNE-MEDIATED CONTROL OF HIV (REMISSION) IS RELATIVELY RARE, MANY SUCH CASES HAVE BEEN DESCRIBED. OUR PROPOSED “MARTIN DELANEY COLLABORATORY FOR HIV CURE RESEARCH” PROGRAM IS ENTITLED “REACH” - RESEARCH ENTERPRISE TO ADVANCE A CURE FOR HIV. THE CENTRAL THEME OF REACH IS THAT CELLULAR IMMUNE RESPONSES (NK AND T-CELLS), COMBINED WITH NEXT GENERATION VIRUS-NEUTRALIZING BIOLOGICS, CAN BE HARNESSED TO ACHIEVE DURABLE REMISSION AND ERADICATION OF HIV RESERVOIRS. THE PROPOSED RESEARCH FOCUSES ON CLOSING GAPS IN OUR UNDERSTANDING OF THE FUNDAMENTALS OF THE SYSTEM THAT WE ARE TRYING TO PERTURB, I.E.: THE HIV RESERVOIR IN RELATION TO CELLULAR IMMUNITY, AS THE MEANS TO ACHIEVE REAL PROGRESS TOWARDS EFFECTIVE AND VIABLE HIV CURE STRATEGIES. OUR APPROACH CENTERS AROUND THREE RESEARCH FOCI, WHICH EMPHASIZE BACK TO BASICS SCIENCE, BUT CONNECT THIS WITH DISCOVERY TO TRANSLATIONAL PIPELINES DIRECTED TOWARDS BOTH REMISSION AND ERADICATION. THE PROPOSED OBJECTIVES, BROADLY DEFINED, AIM TO: (1) REDEFINE THE THREE-WAY RELATIONSHIP BETWEEN THE PERSISTENT HIV RESERVOIR, CD8+ T-CELLS, AND REBOUND VIRUS AT THE LEVELS OF: SINGLE CELLS, INDIVIDUALS, AND DIVERSE POPULATIONS, (2) HARNESS CONVENTIONAL AND UNCONVENTIONAL (BNAB-INDUCED) CD8+ T-CELLS RESPONSES, IN COMBINATION WITH BNABS AND ‘NEXT GENERATION’ BIOLOGICS, TO ACHIEVE DURABLE CONTROL OF HIV REPLICATION, AND (3) DEVELOP A DISCOVERY-TO- TRANSLATION PIPELINE TO OVERCOME MULTIPLE BARRIERS TO THE ERADICATION OF HIV RESERVOIRS BY CTL/NK CELLS. THESE STUDIES WILL BE ROOTED IN A STRONG BASIC SCIENCE PROGRAM THAT WILL CONTEXTUALIZE RESULTS WITH NOVEL INSIGHTS INTO BARRIERS TO IMMUNE-MEDIATED RESERVOIR ELIMINATION, INCLUDING THE ROLE OF THE PROVIRAL INTEGRATION SITE AND OF VIRAL AND HOST FACTORS INFLUENCING IMMUNE SUSCEPTIBILITY. OUR PROGRAM PRIORITIZES THE STUDY OF DIVERSE POPULATIONS, INCLUDING AFRICAN POPULATIONS INFECTED WITH NON-B SUBTYPE VIRUS, AND WOMEN – BOTH TO ADVANCE TOWARDS A CURE FOR ALL, AND TO BENEFIT FROM DIVERSE PERSPECTIVES AS A SOURCE OF FUNDAMENTAL INSIGHTS. THESE OBJECTIVES WILL BE REALIZED BY A GROUP OF ACCOMPLISHED INVESTIGATORS OF DIVERSE EXPERTISE AND WITH STRONG COLLABORATIVE HISTORIES, ALONG WITH COMMUNITY AND INDUSTRY PARTNERS.
Agency for International Development
$27.3M
THE FEED THE FUTURE INNOVATION LAB CROP IMPROVEMENT WILL BE ENABLE THE DEVELOPMENT OF GLOBAL PORTFOLIO OF CROP IMPROVEMENT RESEARCH-FOR-DEVELOPMENT ACTIVITIES.
Department of Health and Human Services
$27M
IMMUNOLOGIC AND VIROLOGIC DETERMINANTS OF CONGENITAL CYTOMEGALOVIRUS TRANSMISSION AND DISEASE IN RHESUS MONKEYS
Department of Health and Human Services
$26M
PEDIATRIC PHYSICIAN SCIENTIST PROGRAM AWARD
Department of Health and Human Services
$24.9M
DISTINCT AND OVERLAPPING PATHWAYS OF FIBROSIS AND EMPHYSEMA IN CIGARETTE SMOKERS
Department of Health and Human Services
$24.8M
MACCHESS SYNCHROTRON SOURCE FOR STRUCTURAL BIOLOGY
National Science Foundation
$24.5M
STC: CENTER FOR RESEARCH ON PROGRAMMABLE PLANT SYSTEMS
National Science Foundation
$23.8M
CORNELL CENTER FOR MATERIALS RESEARCH - MRSEC
Department of Health and Human Services
$23.3M
TISSUE REGULATION OF T CELL FUNCTION
National Science Foundation
$23M
MIP: PLATFORM FOR THE ACCELERATED REALIZATION, ANALYSIS, AND DISCOVERY OF INTERFACE MATERIALS (PARADIM)
Department of Energy
$21.3M
CENTER FOR ALKALINE-BASED ENERGY SOLUTIONS (CABES)
Department of Defense
$21.2M
THE MATERIALS SOLUTIONS NETWORK AT CORNELL HIGH ENERGY SYNCHROTRON SOURCE
National Science Foundation
$21.2M
OPERATION OF THE CORNELL HIGH ENERGY SYNCHROTRON RADIATION LABORATORY (CHESS)
Department of Health and Human Services
$21.2M
MATERNAL AND INFANT IMMUNIZATION TO ELIMINATE BREAST MILK TRANSMISSION OF HIV-1
National Science Foundation
$20M
RESEARCH INFRASTRUCTURE: MID-SCALE RI-1 (MI:IP): X-RAYS FOR LIFE SCIENCES, ENVIRONMENTAL SCIENCES, AGRICULTURE, AND PLANT SCIENCES (XLEAP) -SUPPORT FROM THIS AWARD WILL ALLOW FOR CONSTRUCTION OF A NEW, WORLD-LEADING SYNCHROTRON BEAMLINE DELIVERING X-RAYS FOR LIFE, ENVIRONMENTAL, AGRICULTURAL, AND PLANT SCIENCES (XLEAP) AT THE CORNELL HIGH ENERGY SYNCHROTRON SOURCE (CHESS). THE XLEAP FACILITY WILL PROVIDE USERS WITH A MICRO-FOCUSED, ENERGY-TUNABLE, HIGHLY FLEXIBLE X-RAY MICROSCOPE AND CUSTOM PLANT GROWTH CHAMBERS FOR STUDYING LIVING SYSTEMS IN AS CLOSE TO NATURAL CONDITIONS AS POSSIBLE. THE XLEAP INSTRUMENT WILL PROVIDE RESEARCHERS A UNIQUE COMBINATION OF X-RAY TECHNIQUES INCLUDING 2D AND 3D ELEMENTAL IMAGING MODES, OXIDATION STATE MEASUREMENTS, AND COMPLEMENTARY NON-X-RAY MICROSCOPY. TOGETHER, THESE NEW RESOURCES WILL ENABLE RESEARCHERS TO ASK AND ANSWER ENTIRELY NEW QUESTIONS ABOUT HOW PLANTS TAKE UP, TRANSPORT, AND USE METALS AND MICRONUTRIENTS; HOW PLANTS RESPOND TO ENVIRONMENTAL STIMULI LIKE BACTERIA, MICROPLASTICS, AND CLIMATE; HOW METALS ARE TRANSFORMED IN SOIL DEGRADATION PROCESSES AND AT THE SOIL-ROOT INTERFACE; AND HOW METALS AND MICRONUTRIENTS ARE TAKEN UP AND STORED IN MARINE PLANT AND ANIMAL LIFE. THESE RESEARCH QUESTIONS ARE CRITICAL TO EFFORTS TO DEVELOP NUTRITIOUS AND CLIMATE RESILIENT CROPS, IMPROVE AGRICULTURAL PRACTICES, AND REDUCE HUMAN IMPACTS ON THE ENVIRONMENT. XLEAP WILL LEVERAGE A RELATIONSHIP WITH THE CORNELL SCHOOL OF INTEGRATIVE PLANT SCIENCES TO ENGAGE ITS FUTURE USER COMMUNITY DURING CONSTRUCTION. FURTHERMORE, A PARTNERSHIP BETWEEN CORNELL AND THE UNIVERSITY OF TEXAS AT EL PASO (UTEP) WILL ALLOW FOUR UTEP GRADUATE STUDENTS TO GAIN HANDS-ON TRAINING IN PROJECT MANAGEMENT AND CUTTING-EDGE X-RAY TECHNIQUES AS THEY PERFORM PILOT PROJECTS THAT HELP COMMISSION XLEAP'S CAPABILITIES. XLEAP WILL PROVIDE A UNIQUE COMBINATION OF CAPABILITIES, INCLUDING (1) BOTH HIGH FLUX AND HIGH-ENERGY-RESOLUTION SUBMICRON MODES, (2) SUB-MICRON FOCUSED X-RAYS FROM 5-30 KEV, (3) ?1 ?M FOCUSED X-RAYS FROM 30-70 KEV, (4) AN OPEN SAMPLE AREA ACCOMMODATING CUSTOM IN-SITU PLANT GROWTH CHAMBERS AND RHIZO-BOXES AS WELL AS A CRYOSTAT, (5) CHESS-DEVELOPED 3D CONFOCAL MICRO-X-RAY FLUORESCENCE (XRF), AND (6) DEDICATED OPTICAL MICROSCOPY INTEGRATED WITH X-RAY MICROSCOPY WORKFLOWS. THE FACILITY WILL ALSO INCLUDE AN ON-SITE GROWTH CHAMBER FOR CONTROLLED ENVIRONMENTS DURING BEAMTIME, AS WELL AS DEDICATED SAMPLE PREPARATION FACILITIES (STEREOMICROSCOPE, MICROTOME, CRYO-MICROTOME) FOR ROOM-TEMPERATURE AND FROZEN HYDRATED TISSUES. XLEAP WILL OFFER XRF IMAGING, TOMOGRAPHY, AND CONFOCAL MODES; X-RAY ABSORPTION SPECTROSCOPY (XAS) IN TIME-RESOLVED OR SPATIALLY RESOLVED MODES; AND MICRO- X-RAY DIFFRACTION (XRD) IMAGING. COMBINATIONS (E.G. XRF + XRD) AND RAPID SWITCHES BETWEEN THESE MODES (E.G. FROM XRF TO XAS) WILL BE IMPORTANT IN THE DESIGN AND CONSTRUCTION OF THE BEAMLINE. THE ABILITY TO STUDY LIVING PLANTS IN-SITU IN A CUSTOMIZED GROWTH CHAMBER ON THE BEAMLINE WILL ENABLE RESEARCHERS TO EXAMINE GENOTYPE-PHENOTYPE RELATIONSHIPS IN NON-STRESSED TISSUES. MICROFOCUSED X-RAYS AT ENERGIES >40 KEV AND CUTTING-EDGE DETECTORS WITH LOW PER-PIXEL DWELL TIMES WILL MINIMIZE RADIATION DOSE AND DAMAGE TO LIVING TISSUE, ENABLING STUDY OF DYNAMIC CHANGES IN LIVING TISSUES ON MULTIPLE TIME SCALES. HIGH ENERGIES WILL OFFER HIGH-SENSITIVITY UNAMBIGUOUS MEASUREMENTS OF HIGH-Z ELEMENTS LIKE IODINE AND RARE EARTH ELEMENTS. IN THE 5-30 KEV RANGE, SUBMICRON X-RAYS WILL ENABLE CELLULAR-LEVEL STUDIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.
Department of Health and Human Services
$19M
CENTER RESEARCH AND EDUCATION FOR AGING AND TECHNOLOGY
National Science Foundation
$18.6M
CORNELL CENTER FOR MATERIALS RESEARCH - CEMRI
Department of Health and Human Services
$18.5M
HEALTH ECONOMICS OF SUBSTANCE USE DISORDER, HCV, AND HIV TREATMENT IN THE ERA OF INTEGRATED HEALTH CARE
Department of Energy
$17.9M
TAS::89 0321::TAS LARGE-SCALE PRODUCTION OF FUELS AND FEED FROM MARINE MICROALGAE
Department of Energy
$17M
CORNELL UNIVERSITY ''MULTI-UNIVERSITY CENTER OF EXCELLENCE FOR PULSED POWER-DRIVEN HIGH ENERGY DENSITY SCIENCE'' NEW AWARD PROVIDES INCREMENTAL FUNDING TO FULLY FUND BUDGET PERIOD 1 OF THE PROJECT PERIOD
Department of Health and Human Services
$16M
STRUCTURE AND IMMUNOGENICITY OF CLEAVED, STABILIZED HIV-1 ENVELOPE TRIMERS
Department of Health and Human Services
$15.9M
CORNELL FIRST - CORNELL UNIVERSITY AIMS TO INCREASE THE NUMBER OF MINORITIZED FACULTY IN THE BIOLOGICAL, BIOMEDICAL, AND HEALTH SCIENCES THROUGH ESTABLISHING AN NIH FIRST PROGRAM AT CORNELL UNIVERSITY. CORNELL FIRST WILL SUPPORT THE HIRING AND RETENTION OF 10 NEW ASSISTANT PROFESSORS FROM GROUPS UNDERREPRESENTED IN THEIR FIELDS, WHILE TRANSFORMING INSTITUTIONAL CLIMATE INTO A CULTURE OF INCLUSIVE EXCELLENCE. THE STRENGTH OF CORNELL’S PROGRAM IS ITS FOUNDATIONAL ROOTS AS A COMPLEX PRIVATE INSTITUTION WITH A PUBLIC MISSION, WITH ITS FOUNDING BASED ON SUPPORT FOR DIVERSITY, A CULTURE OF INTERDISCIPLINARY RESEARCH, AND A TRACK RECORD OF CATALYZING CHANGE AT DIFFERENT SCALES THAT WERE INSTITUTIONALIZED. GIVEN CORNELL’S SUCCESS IN ESTABLISHING PROGRAMS FOR THE EFFECTIVE DEVELOPMENT AND SUPPORT OF EARLY-CAREER FACULTY, PARTICULARLY THOSE UNDERREPRESENTED IN THEIR FIELDS, CORNELL IS IN AN EXCELLENT POSITION TO TEST THE HYPOTHESIS THAT FIRST COHORT FACULTY WILL BE SUCCESSFUL IN AN ENVIRONMENT THAT SUPPORTS ADVOCACY THROUGH SPONSORSHIP, CONSISTENT AND INDIVIDUAL-CENTERED MENTORING, AND EVIDENCE-BASED PROFESSIONAL DEVELOPMENT. WE FURTHER HYPOTHESIZE THAT CORNELL’S INSTITUTIONAL CULTURE AND SCIENTIFIC EXCELLENCE WILL BE ENHANCED WITH THE HIRING OF A FIRST COHORT OF DIVERSE FACULTY. CORNELL’S FIRST PROGRAM FEATURES INTERDISCIPLINARY HIRING OF FACULTY UNDERREPRESENTED IN THEIR FIELDS, ACROSS SIX COLLEGES AND 20 DEPARTMENTS, WITH A FOCUS ON RETENTION, CAREER DEVELOPMENT, AND EVALUATION. CORNELL PROPOSES 1) TO HIRE A DIVERSE COHORT OF 10 NEW FACULTY INTO 3 RESEARCH CLUSTERS, TAKING ADVANTAGE OF CORNELL’S EXISTING INTERDISCIPLINARY FIELD SYSTEM APPROACH WHERE FACULTY ARE ORGANIZED BY RESEARCH INTEREST RATHER THAN BY DEPARTMENT, WITHIN BROAD AREAS OF QUANTITATIVE BIOMEDICAL SCIENCES, INFECTION BIOLOGY, AND HEALTH EQUITY; 2) FOSTER SUSTAINABLE INSTITUTIONAL CULTURE CHANGE USING NOVEL COMBINATIONS OF INSTITUTIONAL POLICIES THAT IMPACT HIRING, MENTORING, PROMOTION AND TENURE, SALARY EQUITY, AND OTHER INITIATIVES AIMED AT ENHANCING COMPOSITIONAL DIVERSITY, RETENTION, AND SUCCESS; 3) ENHANCE FACULTY DEVELOPMENT, RETENTION, PROGRESSION, AND PROMOTION BUILDING ON CORNELL’S TRACK RECORD OF SUCCESSFULLY DEVELOPING AND IMPLEMENTING CUTTING EDGE PROGRAMS THAT EFFECTIVELY SUPPORT FACULTY THROUGH THEIR CAREER, PARTICULARLY THOSE UNDERREPRESENTED IN THEIR FIELDS; AND 4) TO EVALUATE AND LEARN FROM OUR HIRING, CLIMATE, AND FACULTY DEVELOPMENT APPROACHES BY IDENTIFYING WHICH STRATEGIES AND ACTIVITIES ARE MOST EFFECTIVE AND SUSTAINABLE AT AN INSTITUTIONAL SCALE ASSESSING OUR PROGRESS TO ENSURE THAT THEY ARE DEVELOPED AND IMPLEMENTED IN AN EFFECTIVE MANNER, AND EFFECTIVELY INTERACT WITH THE FIRST CEC. WE EXPECT THAT THE CORNELL FIRST PROGRAM WILL SUCCESSFULLY HIRE, RETAIN, AND SUPPORT 10 NEW FACULTY UNDERREPRESENTED IN THEIR FIELDS, WHILE FOSTERING SUSTAINABLE INSTITUTIONAL CULTURE CHANGE TO SUPPORT INCLUSIVE EXCELLENCE. CORNELL FIRST WILL INCREASE FACULTY DIVERSITY IN THE BIOLOGICAL, BIOMEDICAL, AND HEALTH SCIENCES WHILE CONTRIBUTING TO THE DIVERSITY OF ACADEMY, AND FUTURE GENERATIONS OF THE STEM WORKFORCE.
Department of Health and Human Services
$15.8M
TRANSMISSION AEROBIOLOGY OF M. TUBERCULOSIS: GENES AND METABOLIC PATHWAYS THAT SUSTAIN MTB ACROSS AN EVOLUTIONARY BOTTLENECK - ABSTRACT UNLESS COVID OVERTAKES IT, TUBERCULOSIS IS LIKELY TO KEEP ITS GRIP ON ITS GRIM RECORD OF BEING THE LEADING INFECTIOUS CAUSE OF HUMAN DEATH. HUMANS ARE THE ONLY KNOWN NATURAL HOST AND TRANSMITTING RESERVOIR FOR THE CAUSATIVE AGENT, MYCOBACTERIUM TUBERCULOSIS (MTB). THIS MEANS THAT PERSON-TO-PERSON TRANSMISSION THROUGH AIR IS ESSENTIAL FOR MTB'S SURVIVAL AS A SPECIES. DESPITE MULTIFACETED EFFORTS TO REDUCE TB'S TRANSMISSIBILITY, TB'S REPRODUCTIVE NUMBER, RO, REMAINS AMONG THE HIGHEST OF FREQUENTLY-LETHAL INFECTIOUS DISEASES. AEROGENIC TRANSMISSION IS A STAGE IN MTB'S LIFE CYCLE THAT MUST HAVE BEEN SUBJECTED TO STRONG EVOLUTIONARY PRESSURES, YET OUR KNOWLEDGE OF MTB'S TRANSMISSION BIOLOGY IS SORELY LACKING. THE PROBLEM HAS BEEN NEARLY INACCESSIBLE TO BASIC-SCIENCE STUDY FOR WANT OF SUITABLE TECHNOLOGIES AND ANIMAL MODELS. THIS PROGRAM PROJECT PROPOSES TO LAY A BASIC-SCIENCE FOUNDATION FOR POTENTIAL NEW TRANSMISSION BLOCKING INTERVENTIONS BY BRINGING A SYNERGISTIC COMBINATION OF INVESTIGATORS AND DISCIPLINES TOGETHER FOR A COLLABORATIVE ATTACK THAT MOBILIZES GENOME-WIDE SCREENING UNDER TRANSMISSION-RELEVANT CONDITIONS, CHARACTERIZES MTB'S METABOLOMIC, LIPIDOMIC AND BIOCHEMICAL RESPONSES TO THOSE CONDITIONS, INTRODUCES AND IMPROVES ANIMAL MODELS, AND USES AEROSOL PHYSICS AS A GUIDE AND TOOL. PROJECT 1 WILL IDENTIFY GENES THAT MTB REQUIRES TO SURVIVE THE TRANSITIONS BETWEEN MAJOR STATES THAT THE PATHOGEN ENCOUNTERS EN ROUTE TO, DURING AND AFTER AEROSOL TRANSMISSION. PROJECT 2 WILL IDENTIFY CONSERVED, ESSENTIAL METABOLIC PROGRAMS IN MTB THAT HAVE EVOLVED IN RESPONSE TO TRANSMISSION-RELATED STRESSES, SUCH AS CHANGES IN HUMIDITY AND GAS COMPOSITION. PROJECT 3 BUILDS ON THE RECENT DISCOVERY OF COUGH-INDUCING LIPIDS PRODUCED BY MTB TO CHARACTERIZE AN EVEN MORE POTENT TUSSIVE LIPID AS A VIRULENCE FACTOR AND TO DEVELOP A MODEL OF COUGH-BASED TRANSMISSION AMONG GUINEA PIGS. PROJECT 4 CHARACTERIZES THE PHYSICAL AND RHEOLOGICAL PROPERTIES OF RESPIRATORY FLUIDS RELEVANT TO TB TRANSMISSION AND USES THAT INFORMATION TO CONTROL THE MECHANICAL GENERATION OF PHYSIOLOGICALLY RELEVANT, RESPIRABLE AEROSOLS OF MTB. CORE A ENSURES THE EFFICIENT FLOW OF INFORMATION, PERSONNEL AND MATERIEL AMONG THESE INTERCONNECTED UNITS, WHILE CORE B DEVELOPS A MOUSE MODEL OF SIMULATED TRANSMISSION USING THE AEROSOLIZATION DEVICE AND SETTINGS OF PROJECT 4 AND APPLIES THAT MODEL TO CONFIRM WHICH GENES MTB DEPENDS ON TO SURVIVE AEROSOL TRANSMISSION TO A NEW HOST.
Department of Health and Human Services
$15.5M
MACROMOLECULAR DIFFRACTION RESOURCE: MACCHESS
Department of Health and Human Services
$15.3M
CENTER FOR LUPUS RESEARCH
Department of Health and Human Services
$15.2M
PATHWAY ANALYSIS IN TUBERCULOSIS
National Science Foundation
$15.2M
NSF I-CORPS HUB (TRACK 1): INTERIOR NORTHEAST REGION -THE BROADER IMPACT/COMMERCIAL POTENTIAL OF THIS NSF I-CORPS HUB PROJECT IS THE DEVELOPMENT OF A REGIONAL NETWORK THAT OFFERS A REPEATABLE, INCLUSIVE MODEL OF EDUCATION AND WORKFORCE TRAINING DESIGNED FOR AND BY INNOVATORS IN RURAL AREAS AND SMALL CITIES. THE INTERIOR NORTHEAST REGION IS REPRESENTATIVE OF LARGE PORTIONS OF THE US THAT ARE RURAL, ECONOMICALLY UNDERSERVED, AND STRUGGLING TO REDUCE OUT-MIGRATION AND RESTORE ECONOMIC VITALITY AFTER THE DECLINE OF MANUFACTURING AND EXTRACTIVE INDUSTRIES. THE REGION ALSO IS RICH IN NATURAL RESOURCES, OPEN SPACE, AND STRONG RESEARCH UNIVERSITIES. THE INTERIOR NORTHEAST REGION I-CORPS HUB SEEKS TO DEPLOY INCLUSIVE TEACHING AND PROGRAM DEVELOPMENT PRACTICES TO SUPPORT INNOVATORS OUTSIDE MAJOR METRO AREAS IN A WAY THAT BROADENS PARTICIPATION AND REPRESENTS A RISING TIDE OF OPPORTUNITY FROM INNOVATION ACROSS ALL REGIONS, RATHER THAN ONE THAT IS CONCENTRATED IN A FEW LARGE CITIES. A PARTICULAR EMPHASIS IS PLACED ON I-CORPS PROGRAMS FOR THE DEAF AND HARD OF HEARING. THE I-CORPS INTERIOR NORTHEAST HUB INSTITUTIONS WILL CREATE A ?HUB OF HUBS? INFRASTRUCTURE TO CONNECT REGIONAL RESEARCH LABORATORIES AND INSTITUTIONS WITH A SMALLER SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) RESEARCH FOOTPRINT TO I-CORPS. THE HUB PROPOSES TO RECRUIT DIVERSE INSTRUCTORS, MENTORS, AND STAFF SO UNDERREPRESENTED MINORITIES FIND OPPORTUNITIES AT ALL LEVELS OF I-CORPS. LEARNINGS FROM THE DEPLOYMENT OF PROGRAMS TO THE DEAF AND HARD OF HEARING, RECRUITMENT OF DIVERSE INSTRUCTORS AND TEAMS, AND SUPPORT FOR THE GROWTH OF RURAL INNOVATION COMMUNITIES WILL BE DISSEMINATED THROUGHOUT THE NATIONAL INNOVATION NETWORK. THIS I-CORPS HUB PROJECT PROVIDES INCLUSIVE I-CORPS TRAINING, MENTORING AND SUPPORT TO STEM RESEARCHERS ACROSS THE INTERIOR NORTHEAST REGION, TO ACCELERATE THE TRANSLATION OF BASIC RESEARCH DISCOVERIES TO PRODUCTS AND SERVICES THAT BENEFIT SOCIETY AND TO REDUCE THE RISK OF PURSING COMMERCIALIZATION WITHOUT INSIGHTS INTO INDUSTRY NEEDS AND CHALLENGES. IN ADDITION, THE HUB PROPOSES TO PROVIDE A PROGRAM INFRASTRUCTURE THAT ALLOWS INNOVATORS OUTSIDE MAJOR METRO AREAS TO RECEIVE THE BENEFITS OF LEARNING THE I-CORPS METHOD OF CUSTOMER DISCOVERY AND APPLYING IT TO OPPORTUNITIES WHILE REMAINING CONNECTED TO THEIR HOME INSTITUTIONS. PARTICIPANTS WILL GLEAN THE BENEFITS OF BEING PART OF A DIVERSE COHORT OF INNOVATORS IN A VIBRANT RURAL REGION. TO ACHIEVE THESE GOALS, THE HUB PROPOSES TO FOCUS ON: 1) MAXIMIZING THE REACH AND REPUTATION OF I-CORPS WITH DEEP TECH RESEARCHERS BY ENGAGING ESTEEMED STEM FACULTY WHO VALUE I-CORPS AS PROGRAM AMBASSADORS, THOUGHT LEADERS AND HUB ADVISORS; 2) PROVIDING NUMEROUS LEARNING OPPORTUNITIES THAT SUPPORT GEOGRAPHICALLY-DISPERSED PARTICIPANTS AND ARE LED BY EXPERIENCED INSTRUCTORS WHO UTILIZE INCLUSIVE TEACHING PRACTICES; AND 3) SUPPORTING THE PROFESSIONAL DEVELOPMENT OF STEM RESEARCHERS WHO ARE UNDERREPRESENTED MINORITIES (URMS) INCLUDING WOMEN, VETERANS, PEOPLE OF COLOR, AND PEOPLE WITH DISABILITIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
Department of Health and Human Services
$14.1M
NE-CAT CENTER FOR ADVANCED MACROMOLECULAR CRYSTALLOGRAPHY
National Science Foundation
$13.3M
BIOLOGY OF RARE ALLELES IN MAIZE AND ITS WILD RELATIVES
Department of Health and Human Services
$13M
DETERMINANTS OF TB CONTROL, RELAPSE AND REINFECTION - MYCOBACTERIUM TUBERCULOSIS (MTB), THE CAUSATIVE AGENT OF TUBERCULOSIS (TB), CONTINUES TO BE A SEVERE GLOBAL HEALTH PROBLEM. TB IS MULTIFACETED, BUT A CENTRAL CLINICAL AND MICROBIOLOGIC FEATURE OF THE DISEASE IS THE ABILITY OF MTB TO RESIST COMPLETE ELIMINATION, BOTH BY THE HOST IMMUNE SYSTEM AND BY CHEMOTHERAPEUTIC AGENTS WITH POTENT GROWTH INHIBITORY ACTIVITY. THIS PERSISTENCE IN THE FACE OF IMMUNOLOGIC AND ANTIBIOTIC PRESSURE UNDERLIES SEVERAL IMPORTANT FACETS OF TB DISEASE, INCLUDING 1) THE EXISTENCE OF LATENT TUBERCULOSIS INFECTION (LTBI) AND, IN THE SETTING OF IMMUNOLOGIC FAILURE OF LTBI CONTROL, ITS ROLE IN THE GENESIS OF ACTIVE TB AND 2) THE PROLONGED COURSE OF TB ANTIBIOTIC THERAPY, WHICH REQUIRES 6 MONTHS OF MULTIDRUG THERAPY TO ACHIEVE RELIABLE CLINICAL CURE. RATHER THAN PRODUCING COMPLETE BACTERIAL ERADICATION IN ALL TREATED SUBJECTS, CURE FOLLOWING TB CHEMOTHERAPY IS NOW UNDERSTOOD TO BE AN ANTIBIOTIC INDUCED PAUCIBACILLARY STATE IN WHICH PREVENTION OF RELAPSE DEPENDS IN PART ON POORLY UNDERSTOOD HOST FACTORS. THE HOST AND BACTERIAL DETERMINANTS THAT MEDIATE THESE TWO INTERRELATED TYPES OF PERSISTENCE ARE ONLY PARTIALLY UNDERSTOOD, A KNOWLEDGE GAP THE TRI-I-TBRU AIMS TO FILL. WE PROPOSE A SET OF 3 INTERSECTING PROJECTS AND 3 CORES ALL FOCUSED ON DIFFERENT FACETS OF THE PROBLEM OF PAUCIBACILLARY TB, BOTH POST TREATMENT AND LTBI. THE PROJECTS WILL USE SAMPLES AND CLINICAL DATA FROM TB COHORTS AT OUR CLINICAL SITE AT GHESKIO IN PORT AU PRINCE HAITI, TO EXAMINE THE IMMUNOLOGIC, MICROBIOMIC, TRANSCRIPTOMIC, PHARMACOKINETIC, AND GENETIC FACTORS THAT INFLUENCE OR PREDICT THE TRANSITION POINTS BETWEEN PAUCIBACILLARY STATES OF TB DISEASE AND ACTIVE TRANSMISSIBLE INFECTION. THESE HUMAN STUDIES WILL BE COMPARED AND CONTRASTED WITH A NEW MOUSE MODEL OF PAUCIBACILLARY INFECTION THAT WILL ALLOW US TO TEST MECHANISTIC HYPOTHESES ABOUT THE HOST AND BACTERIAL DETERMINANTS OF PAUCIBACILLARY DISEASE. THIS WORK WITH BE CONDUCTED BY A TEAM OF HIGHLY COLLABORATIVE INVESTIGATORS WHO HAVE WHO HAVE WORKED WELL TOGETHER FOR SEVERAL YEARS.
National Science Foundation
$12.7M
MRSEC: CORNELL CENTER FOR MATERIALS RESEARCH
Department of Health and Human Services
$12.6M
CENTER ON THE MICROENVIRONMENT AND METASTASIS
Department of Health and Human Services
$12.4M
RISK GENES AND ENVIRONMENT INTERACTIONS IN NTDS
Department of Health and Human Services
$12.3M
STRUCTURE, FUNCTION, AND DYNAMICS OF MACRO-MOLECULAR COMPLEXES THAT EXECUTE AND REGULATE GENOME FUNCTION - PROJECT SUMMARY/ABSTRACT THE GENETIC INFORMATION ENCODED IN OUR GENOME IS DECODED AND IMPLEMENTED VIA MANY MULTI-STEP PROCESSES, INCLUDING THE PROPER DECODING BY TRANSCRIPTION. TRANSCRIPTION OF GENES INTO MRNA BY RNA POLYMERASE II (POL II) IS A COMPLEX PROCESS THAT IS PRECISELY REGULATED BOTH TEMPORALLY AND SPATIALLY AT MULTIPLE STEPS BY MANY LARGE MOLECULAR COMPLEXES (LMCS). IN THE PAST, A NUMBER OF THESE LMCS HAVE BEEN IDENTIFIED AND THEIR STRUCTURAL AND FUNCTIONAL ROLE HAS BEEN STUDIED. ALTHOUGH WE HAVE LEARNED A GREAT DEAL ABOUT THESE LMCS AT AN INDIVIDUAL LEVEL, HOW THESE LMCS INTERACT AND AFFECT ONE ANOTHER AND POL II AT A MORE COMPREHENSIVE LEVEL HAS YET TO BE ACHIEVED. IN THIS PROJECT, WE ARE PROPOSING A MULTI-PRONG APPROACH TO DEFINE INTERACTIONS AND STRUCTURES OF LMCS, POL II, AND MODEL TRANSCRIPTION FACTORS (TFS) IN AN UNBIASED WAY AND, AS MUCH AS POSSIBLE, UNDER NATIVE CONDITIONS. WE WILL ALSO EVALUATE THE FUNCTION OF THESE SPECIFIC INTERACTIONS ON THE MOLECULAR MECHANICS OF TRANSCRIPTION AND REGULATION IN CELLS. TO THIS END, WE WILL UTILIZE A NOVEL GFP APTAMER-BASED PURIFICATION METHOD TO IDENTIFY LMCS AND TFS THAT ASSOCIATE WITH GFP-TAGGED POL II AND OTHER CRITICAL LMCS. PURIFICATIONS WILL BE PERFORMED RAPIDLY AND UNDER NATIVE CONDITIONS TO ENSURE RETENTION OF PHYSIOLOGICAL INTERACTIONS, AND THE RESULTING COMPLEXES WILL BE ANALYZED BY BOTH MASS SPECTROMETRY AND CRYO-EM TO DEFINE THE COMPOSITION AND STRUCTURE OF THESE LMCS AT THE HIGHEST DEPTH AND RESOLUTION POSSIBLE. CROSSLINKING WITH NOVEL PROTEIN-PROTEIN CROSSLINKERS AND SUBSEQUENT MS ANALYSIS (XL-MS) WILL ALSO BE USED TO CAPTURE MORE TRANSIENT LMC AND TF INTERACTIONS. IN PARALLEL, LMC-APEX2 FUSIONS WILL BE USED TO BIOTINYLATE NEARBY PROTEINS AND IDENTIFY THEM BY MS ANALYSIS FOLLOWING STREPTAVIDIN PURIFICATION. ADDITIONALLY, WE WILL DEFINE THE LOCATION OF DISTINCTLY MODIFIED POL II COMPLEXES OR POL II ASSOCIATED WITH DISTINCT LMCS AT BASE-PAIR RESOLUTION ALONG TRANSCRIPTION UNITS USING OUR NEW PRO-IP-SEQ PROTOCOL. THIS INFORMATION COMBINED WITH THE MS ANALYSIS PROVIDES A UNIQUE AND DYNAMIC VIEW OF POL II’S PHOSPHORYLATION STATUS, COMPOSITION, ASSOCIATIONS, AND PRECISE POSITIONING ALONG GENES, AND THIS INFORMATION WILL BE CRITICAL IN DERIVING MOLECULAR MODELS OF TRANSCRIPTION AND ITS REGULATION. PREVIOUSLY KNOWN AND NEWLY IDENTIFIED LMCS AND TFS THAT ARE DEEMED TO HAVE CRITICAL INTERACTIONS WILL BE PERTURBED BY EITHER RNA APTAMER INHIBITORS OR DEGRON- TAGGING TO TEASE APART THEIR FUNCTIONAL ROLES. THE RAPID EXPRESSION RNA APTAMERS, WHICH INTERFERE WITH SPECIFIC LMC INTERACTIONS, AND THE RAPID DEGRADATION OF WHOLE LMC SUBUNITS WITH DEGRON TECHNOLOGY WILL ALLOW THE DETECTION OF THE IMMEDIATE, “PRIMARY” ROLES OF THOSE INTERACTIONS GENOME-WIDE USING THE HIGH-RESOLUTION ASSAYS SUCH AS PRO-SEQ AND CHIP-EXO. THESE ASSAYS WILL ENABLE US TO IDENTIFY THE SPECIFIC FUNCTIONS OF THE KEY LMCS AND THEIR INTERACTIONS AT AN UNPRECEDENTED RESOLUTION AND SENSITIVITY. OVERALL, WE EXPECT TO DERIVE A MUCH BETTER AND MORE COMPLETE UNDERSTANDING OF THE TRANSCRIPTION CYCLE AND ITS REGULATION. THIS WILL IMPACT HUMAN HEALTH BY IDENTIFYING NEW THERAPEUTIC VENUES AND POSSIBLE LEAD DRUGS (RNA APTAMERS), AS MISREGULATION OF TRANSCRIPTION HAS BEEN OBSERVED IN MANY DISEASE CONDITIONS.
Department of Health and Human Services
$12.2M
NORTHEAST REGIONAL CENTER FOR EXCELLENCE IN VECTOR BORNE DISEASES
Department of Health and Human Services
$12.1M
CENTER FOR GENOMIC INFORMATION ENCODED BY RNA NUCLEOTIDE MODIFICATIONS - SUMMARY: POST-TRANSCRIPTIONAL MECHANISMS CONTROL GENE EXPRESSION IN VIRTUALLY EVERY CELL. A MAJOR MEDIATOR OF POST-TRANSCRIPTIONAL GENE REGULATION IS THE TRANSLATING RIBOSOME, WHICH COMPRISES THREE DIFFERENT TYPES OF RNAS: RRNA, TRNA AND MRNA. THESE RNAS, ALONG WITH RIBOSOMAL AND MRNA-BINDING PROTEINS, FORM A MULTI-RNA/MULTI-PROTEIN COMPLEX THAT CAN MARKEDLY INFLUENCE MRNA STABILITY AND TRANSLATION. IMPORTANTLY, THIS COMPLEX IS NOT CONSTITUTIVE. INSTEAD, RRNA-TRNA, RRNA-MRNA, AND TRNA-MRNA INTERACTIONS ARE HIGHLY REGULATED, ALTHOUGH THE MECHANISMS OF ITS REGULATION ARE POORLY UNDERSTOOD. A POTENTIAL MECHANISM MAY INVOLVE CHEMICAL MODIFICATION OF THEIR NUCLEOTIDES. INDEED, RRNA, TRNA AND MRNA ARE SUBJECTED TO DIVERSE CHEMICAL MODIFICATIONS WHOSE STOICHIOMETRY IS HIGHLY REGULATED IN DIFFERENT TISSUES OR DISEASE STATES. OUR UNDERLYING HYPOTHESIS IS THAT THE REGULATED NUCLEOTIDE MODIFICATIONS IN RRNA, TRNA, AND MRNA ACT AS A “CODE” THAT CONTROLS THESE RNAS AND THEIR MUTUAL INTERACTIONS, THUS ENCODING UNIQUE PATTERNS OF GENE EXPRESSION. ALTHOUGH RRNA, TRNA, AND MRNA NUCLEOTIDE MODIFICATIONS ARE POISED TO BE CRITICAL REGULATORS OF GENE EXPRESSION, STUDYING HOW THESE MODIFICATIONS INFLUENCE EACH OTHER TO CONTROL GENE EXPRESSION HAS BEEN DIFFICULT TO EXPLORE. IN PART THIS REFLECTS THE LACK OF SCALABLE METHODS TO QUANTIFY AND PROFILE NUCLEOTIDE MODIFICATIONS IN RRNA, TRNA, AND MRNA. ANOTHER PROBLEM IS THAT UNDERSTANDING THE INTERACTIONS OF RRNA, TRNA, AND MRNA REQUIRES SPECIALIZED EXPERTISE IN EACH OF THESE THREE MAJOR AREAS OF RNA BIOLOGY. IT IS THEREFORE CRITICAL FOR EXPERTS IN RRNA, TRNA, AND MRNA TO WORK TOGETHER TO DECIPHER THE MUTUAL INTERACTIONS OF THESE RNAS. THE CENTER WILL BRING TOGETHER A TEAM OF EXPERTS IN THESE DIVERSE TYPES OF RNAS WHO WILL WORK TOGETHER TO DEVELOP NOVEL TECHNIQUES TO PROBE NUCLEOTIDE MODIFICATIONS AND HOW THEY INTERACT TO ORCHESTRATE UNIQUE PATTERNS OF GENE EXPRESSION. THE CENTER WILL DEVELOP NOVEL TECHNOLOGIES FOR MAPPING AND QUANTIFYING RRNA, TRNA, AND MRNA MODIFICATIONS, IDENTIFY THE DYNAMIC MODIFICATION SITES IN TISSUES AND DISEASE, AND DETERMINE THE FUNCTION OF THESE DYNAMIC MODIFICATIONS. THE METHODS AND DATASETS THAT WILL BE DEVELOPED IN THE CENTER WILL PROVIDE THE FOUNDATIONAL KNOWLEDGE NEEDED TO ACCELERATE NEW AREAS OF EPITRANSCRIPTOMICS RESEARCH IN RRNA, TRNA, AND MRNA BIOLOGY. THE CENTER HAS A MAJOR OUTREACH AND EDUCATIONAL MISSION. THE OUTREACH/EDUCATIONAL OPPORTUNITIES WILL INCLUDE SPONSORED UNDERGRADUATE RESEARCH, BREAKOUT PROJECT FUNDING, PROJECT FUNDING FOR UNDERREPRESENTED MINORITY TRAINEES, FUNDING FOR TRAINING VISITING OUTSIDE INVESTIGATORS, AND FUNDING FOR AN ANNUAL SYMPOSIUM. WE WILL ALSO DEVELOP A WEBSITE THAT CURATES THE EPITRANSCRIPTOMIC MAPPING DATA GENERATED BY THE CENTER TO ENSURE RAPID AND EASY ACCESS TO THE NEW DATA WE GENERATE. OVERALL, THE CENTER’S MISSION IS TO SERVE AS A HUB FOR TRAINING RESEARCHERS IN EPITRANSCRIPTOMICS, AS WELL AS TO DEVELOP NEW ENABLING TECHNOLOGIES, DEVELOP FOUNDATIONAL DATASETS, AND REVEAL FUNDAMENTAL PRINCIPLES OF MODIFIED NUCLEOTIDE FUNCTION IN RRNA, TRNA, AND MRNA THAT ARE NEEDED TO OPEN UP NEW AREAS OF EPITRANSCRIPTOMICS RESEARCH.
Department of Health and Human Services
$12.1M
CENTER FOR RESEARCH AND EDUCATION ON AGING AND TECHNOLOGY ENHANCEMENT - CREATE - PROJECT SUMMARY THE LANDSCAPE OF AGING AND TECHNOLOGY HAS CHANGED DRAMATICALLY. UPTAKE OF TECHNOLOGY IS INCREASING AMONG AGING ADULTS; MORE RESEARCHERS ARE FOCUSING ON THIS TOPIC (MANY OF WHOM ARE CREATE PROGENY); TECHNOLOGY IS INCREASINGLY BEING CONSIDERED AS A SOLUTION FOR THE SUPPORT NEEDS OF AGING ADULTS; AND MORE TECHNOLOGY PRODUCTS ARE MARKETED TO SENIORS. THESE TRENDS UNDERSCORE THE CONTINUED SIGNIFICANCE OF THE CENTER FOR RESEARCH AND EDUCATION ON AGING AND TECHNOLOGY ENHANCEMENT (CREATE). DEPLOYMENT OF TECHNOLOGY IN HEALTHCARE AND DAY-TO-DAY ACTIVITIES IS INCREASING AND ADVANCES IN TECHNOLOGY SUCH AS ARTIFICIAL INTELLIGENCE (AI) ARE INCREASINGLY AIMED AT SUPPORTING OLDER ADULTS. YET, AGING ADULTS ARE OFTEN IGNORED IN DESIGN, AND ROBUST RESEARCH EVALUATING THE USABILITY, SAFETY, AND EFFICACY OF THESE SYSTEMS WITH OLDER ADULTS IS LIMITED. EVEN AMONG OLDER TECHNOLOGY ADOPTERS, RAPID CHANGES IN TECHNOLOGY POSE CHALLENGES IN TERMS OF THE CONSTANT NEED FOR ADAPTATION AND CONTINUAL LEARNING. FURTHER, THERE REMAINS A LAG IN UPTAKE AMONG MANY OLDER ADULT SUB-GROUPS, INCLUDING ETHNIC MINORITIES, OLDER COHORTS, THOSE OF LOWER SOCIO-ECONOMIC STATUS, THOSE LIVING IN A RURAL LOCATION, OR WITH A COGNITIVE IMPAIRMENT SUCH AS MILD COGNITIVE IMPAIRMENT (MCI) OR ALZHEIMER'S DISEASE/ALZHEIMER'S DISEASE RELATED DEMENTIAS (AD/ADRD). THIS APPLICATION IS A REQUEST FOR CONTINUED SUPPORT FOR CREATE, AN ESTABLISHED MULTIDISCIPLINARY, COHESIVE, HIGHLY PRODUCTIVE, AND INNOVATIVE CENTER THAT FOCUSES ON AGING ADULTS AND TECHNOLOGY INTERACTIONS. CREATE’S GOAL IS TO ENSURE THAT OLDER ADULTS ARE ABLE TO USE AND REALIZE THE BENEFITS OF TECHNOLOGY. CREATE V HAS A NEW VISION, EXPANDED RESEARCH PROGRAM AND TEAMS, AND TARGET POPULATIONS, SUCH AS THOSE WITH MCI, EXPANDED TECHNICAL EXPERTISE, AND ACCESS TO AN ARRAY OF RESOURCES, COMMUNITY AND CLINICAL PARTNERS. GIVEN THAT AGE IS A SIGNIFICANT RISK FACTOR FOR COGNITIVE IMPAIRMENTS SUCH AS MCI AND AD/ADRD, AND THE CRITICALITY OF COGNITION TO EVERYDAY FUNCTIONING, A THRUST OF OUR PLANNED RESEARCH IS ON USING EMERGING TECHNOLOGIES TO HELP MAINTAIN COGNITIVE HEALTH AND PROVIDE SUPPORT FOR THOSE WITH COGNITIVE IMPAIRMENTS. OUR RESEARCH PROGRAM INCLUDES THREE HIGHLY INTEGRATED CROSS-SITE PROJECTS FOCUSED ON: 1) ENHANCING COGNITIVE HEALTH AND COGNITIVE AND SOCIAL ENGAGEMENT AND PREVENTING COGNITIVE IMPAIRMENT; 2) PROVIDING SUPPORT FOR ADULTS WITH MCI AND USING INNOVATIVE TECHNIQUES TO ASSESS FURTHER COGNITIVE DECLINE SUCH AS CONVERSION TO AD/ADRD; AND 3) PROVIDING COGNITIVE SUPPORT FOR HEALTH-MANAGEMENT ACTIVITIES FOR THOSE WITH AND WITHOUT COGNITIVE IMPAIRMENTS. OUR CROSS- SITE APPROACH ALLOWS US TO EXAMINE HETEROGENEITY IN RESPONSE TO OUR PROMISING INTERVENTIONS. OUR PROGRAM WILL ALSO INCLUDE AN EXPANDED PILOT RESEARCH PROGRAM TO SUPPORT NEW RESEARCH AND INVESTIGATORS. CREATE WILL INVOLVE THREE MAIN SITES: WEILL CORNELL MEDICINE, FLORIDA STATE U. AND THE U. OF ILLINOIS URBANA-CHAMPAIGN. J. SHARIT WILL REMAIN AS A CO-LEADER (U. OF MIAMI). WE WILL ALSO DRAW ON FACULTY SUPPORT FROM OTHER CAMPUSES AND INSTITUTIONS. THE CENTER WILL INCLUDE ADMINISTRATIVE, DATA AND TECHNICAL DEVELOPMENT, AND DISSEMINATION CORES, EXTERNAL SCIENTIFIC AND COMMUNITY ADVISORY BOARDS, AND AN INDUSTRY ADVISORY COUNCIL.
Department of Energy
$12.1M
CENTER FOR THE STUDY OF PULSED-POWER-DRIVEN HIGH ENERGY DENSITY PLASMAS
Agency for International Development
$11.8M
MOD. FOR 5 YEAR EXTENSION, INCREASE IN TEC AND INCREMENTAL FUNDING/
Department of Health and Human Services
$11.7M
NATIONAL CENTER FOR ADVANCED ESR TECHNOLOGY
National Science Foundation
$11.6M
ATMOSPHERIC SCIENCES (ATM) COOPERATIVE SUPPORT AGREEMENT PY 2006
Department of Health and Human Services
$11.6M
INSTITUTIONAL CAREER DEVELOPMENT CORE
Department of Health and Human Services
$11.4M
CORNELL ROYBAL CENTER FOR TRANSLATIONAL RESEARCH
National Science Foundation
$11.3M
GRADUATE RESEARCH FELLOWSHIP PROGRAM
Department of Health and Human Services
$11.3M
DISARRAY OF INJURY/REGENERATION HOMEOSTASIS IN SMOKING-INDUCED COPD
Department of Energy
$11.2M
CENTER FOR PULSED-POWER-DRIVEN-HIGH-ENERGY-DENSITY PLASMAS
Department of Health and Human Services
$11M
REGULATION OF PROTECTIVE IMMUNITY FOLLOWING ENTERIC VIRAL INFECTION
National Science Foundation
$10.9M
PHASE I ENERGY RECOVERY LINAC (ERL) SYNCHROTRON LIGHT SOURCE AT CORNELL UNIVERSITY
Environmental Protection Agency
$10.9M
THE OBJECTIVE OF THE 'EXPANDING CAPACITY IN ENVIRONMENTAL EDUCATION PROJECT IS TO IMPROVE ENVIRONMENTAL QUALITY THROUGH DIVERSIFYING AND STRENGTHENI
Department of Health and Human Services
$10.9M
FULL YEAR, PART DAY HEAD START AND SERVICES TO CHILDREN WITH HANDICAPPING CONDITIONS
Department of Health and Human Services
$10.9M
WEILL CORNELL MEDICINE (WCM) SPORE IN PROSTATE CANCER
National Science Foundation
$10.8M
CENTER FOR NANOSCALE SYSTEMS IN INFORMATION TECHNOLOGIES
Department of Health and Human Services
$10.8M
LINKING TAU PROTEOSTASIS WITH NEURONAL ACTIVITY IN FTD
Department of Health and Human Services
$10.6M
THE CAPTURE STUDY: VALIDATING A UNIQUE COPD SCREENING TOOL IN PRIMARY CARE
National Science Foundation
$10.6M
CORNELL PROGRAM FOR STUDENT-CENTERED ACCELERATOR SCIENCE
Department of Health and Human Services
$10.4M
PSYCHOSOCIAL APPROACHES TO BETTER UNDERSTANDING & END-STAGE CANCER CARE (PROTECT)
Department of Health and Human Services
$10.2M
PROLIFERATION, NEURAL SPECIFICATION & BRAIN FUNCTION
Department of Health and Human Services
$10.2M
CENTER ON THE PHYSICS OF CANCER METABOLISM
Department of Health and Human Services
$10.1M
CELL INTERACTIONS IN VASCULAR INJURY AND ATHEROGENESIS
National Science Foundation
$9.8M
GENETIC ARCHITECTURE OF MAIZE AND TEOSINTE
Department of Health and Human Services
$9.8M
SIGNAL TRANSDUCTION TO P70 S6 KINASE 1
National Science Foundation
$9.7M
A TECHNOLOGY DEVELOPMENT PROJECT FOR THE LARGE-N/SMALL-D SKA CONCEPT
Department of Agriculture
$9.6M
BREEDING INSIGHT PHASE 2: EXPANSION TO SUPPORT MORE DIVERSE PLANT AND ANIMAL USE CASES - BREEDING INSIGHT (BI) WILL CONTINUE TO SUPPORT BREEDING PROJECTS ACROSS ARS BY WITH A TEAM OF SPECIALISTS IN INFORMATION TECHNOLOGY, GENOMICS, AND BREEDING PROCESS DESIGN WHO PARTNER WITH INDIVIDUAL ARS PRE-BREEDING AND BREEDING GROUPS. THE INITIAL TWO YEARS FOCUSED ON RECRUITING THE BI TEAM, RAMPING UP BREEDING PROGRAMS FOR NEW TECHNOLOGIES, AND INTEGRATING INFORMATICS TOOLS. THE PROJECT LEVERAGES INVESTMENTS IN NINE OPEN SOURCE INFORMATIC TOOLS THAT ARE ALREADY FUNDED BY ARS, CGIAR, USAID, AND BMGF AND BEING USED AND DEVELOPED BY SIX INSTITUTIONS. CURRENTLY, THESE NINE TOOLS COVER THE DOMAIN SPACE (VARIOUS ACTIVITIES) NEEDED FOR MOST BREEDING PROGRAMS TO OPERATE EFFICIENTLY, BUT THEY DO NOT INTER-OPERATE WELL AND SOME NEEDS/ACTIVITIES ARE NOT COVERED (E.G., ANIMAL WELFARE MANAGEMENT). ADDITIONALLY, SOME OF THE TOOLS HAVE BEEN SCALED FOR VERY LARGE PROGRAMS, AND THEY NEED TO BE SIMPLIFIED FOR SMALLER BREEDING PROGRAMS. THE SOFTWARE ENGINEERS WILL CONTINUE TO IMPROVE AND INTEGRATE THESE TOOLS, OR CREATE NEW TOOLS, SO THEY CAN BE APPLIED TO SPECIALTY ANIMAL AND PLANT BREEDING PROGRAMS. INITIALLY, THE PLATFORM ADDRESSES FOUR USE CASES: EFFICIENT GENOTYPING, PEDIGREE VERIFICATION, GENOMIC PREDICTION, AND IDENTIFICATION OF NOVEL FAVORABLE VARIANTS. A DIRECTOR, A SOFTWARE DEVELOPMENT TEAM, AND APPLICATION SPECIALIST COORDINATORS LEAD THIS EFFORT FROM ITHACA, NY. IN THE INITIAL YEARS, THE PROJECT HAS FOCUSED ON SIX BREEDING PROGRAMS DURING THE PILOT PHASE. IN THIS PHASE, THE PROJECT IN COLLABORATION WITH ARS COORDINATORS WILL EXPAND SERVICE AND SUPPORT TO AN ADDITIONAL FIVE SPECIES (BRINGING TOTAL SPECIES SERVED TO ELEVEN). THE SOFTWARE ENGINEERING TEAM IN LATER YEARS WILL FOCUS ON INTEGRATION WITH GERMPLASM COLLECTIONS, SCALING, AND SUPPORT FOR THE WIDE RANGE OF BIOLOGY ENCOUNTERED ACROSS DOZENS OF BREEDING PROGRAMS. BREEDING INSIGHT HAS THE POSSIBILITY OF MORE THAN DOUBLING THE EFFICIENCY OF BREEDING PROGRAMS, WHICH WOULD RESULT IN MORE SUSTAINABLE, NUTRITIOUS, PROFITABLE FRUITS, VEGETABLES, AQUACULTURAL SPECIES, AND RANGE LAND PLANTS. THE SHARED OPEN SOURCE PLATFORM WILL ALSO ALLOW INNOVATION AND TALENT TO BE SHARED MUCH MORE WIDELY. THE OPEN SOURCE SOFTWARE SYSTEM DEVELOPED BY THIS PROJECT WILL ALSO HAVE BROAD APPLICABILITY TO NUMEROUS NON-AGRICULTURAL SPECIES, INCLUDING SPECIES CRITICAL FOR ECOLOGY, CONSERVATION BIOLOGY, PATHOLOGY OR ANY GENOMIC DIVERSITY STUDY. THIS PROJECT CONDUCTS TRAINING TO ENSURE RESEARCHERS IN OTHER COMMUNITIES CAN USE AND CONTRIBUTE TO THE SOFTWARE PLATFORM. ADDITIONALLY, BECAUSE OF THE TRAINING AND THE PLATFORM'S OPEN SOURCE NATURE IT WILL PROVIDE A CATALYST FOR START-UP COMPANIES AND UNIVERSITY-BASED BREEDING PROGRAMS TO ACCELERATE THEIR EFFORTS.
Department of Energy
$9.4M
NEW; SISGR - USING INTERFACES TO CREATE STRONGLY-COUPLED MAGNETIC-FERROELECTRICS; PI - DARRELL G. SCHLOM
Department of Health and Human Services
$9.4M
IMPACT OF BDNF GENOTYPES AND STRESS ON LEARNING AND BRAIN DEVELOPMENT
Department of Health and Human Services
$9.4M
PARTNERSHIP FOR PREVENTION OF HPV-ASSOCIATED CANCERS IN PEOPLE LIVING WITH HIV: BRAZIL, MEXICO, AND PUERTO RICO
Department of Health and Human Services
$9.4M
ELUCIDATING SINGLE CELL CHANGES IN NEUROGENIC BRAIN REGIONS DURING HIV AND CANNABINOID EXPOSURE - PROJECT SUMMARY (ABSTRACT) THE USE OF CANNABIS FOR RECREATION AND MEDICINAL PURPOSES IS DISPROPORTIONATELY HIGH AMONG PEOPLE LIVING WITH HIV (PLWH) AND NEARLY HALF OF CANNABIS USING PLWH ARE ESTIMATED TO BE AT RISK FOR CANNABIS USE DISORDER. YET, WHETHER CANNABIS IS THERAPEUTIC OR DETRIMENTAL ON THE CENTRAL NERVOUS SYSTEM (CNS) OF PLWH REMAINS CONTROVERSIAL, HIGHLIGHTING THE NEED FOR WELL-CONTROLLED STUDIES GENERATING REPRODUCIBLE DATA FROM SPECIFIC CANNABINOIDS, BRAIN REGIONS, AND CNS CELL TYPES. OUR RESEARCH HAS SHOWN THAT CELL-TYPE SPECIFIC EPIGENETIC PATTERNS RELATE TO HIV-ASSOCIATED COGNITIVE IMPAIRMENT IN PLWH, MORE FREQUENT OR RECENT CANNABIS USE MAY REDUCE MYELOID INFLAMMATION AND IMPACT BRAIN STRUCTURE IN PLWH, AND OUR RECENT SINGLE CELL STUDIES OF THE CNS IN PLWH REVEALED DISTINCT CSF MICROGLIA-LIKE CELLS EXPRESSING CD204 IN PLWH AND ONGOING HIV VIRAL TRANSCRIPTION IN CEREBROSPINAL FLUID CELLS DESPITE ART. PRIOR RESEARCH HAS SHOWN NEUROGENIC BRAIN REGIONS INCLUDING THE SUBVENTRICULAR ZONE OF THE LATERAL VENTRICLES AND HIPPOCAMPUS ARE OF HIGH RELEVANCE TO PERSISTENT HIV INFECTION AND CANNABINOID EXPOSURES. HOWEVER, CRITICAL GAPS IN UNDERSTANDING NEUROGENIC BRAIN REGIONS AT SINGLE CELL LEVEL IN THE SETTING OF HIV AND CANNABINOID EXPOSURES REMAIN. WE ARE LEVERAGING BRAIN TISSUES FROM AN ESTABLISHED ORAL DOSING MODEL OF CANNABIDIOL AND THC IN A NONHUMAN PRIMATE (NHP) MODEL OF HIV, APPLICATION OF NEW SINGLE CELL TECHNOLOGIES PERMITTING THE SIMULTANEOUS PROFILING OF GENE EXPRESSION AND OPEN CHROMATIN FROM THE SAME CELL (10X GENOMICS MULTIOME: RNA+ATAC) IN BRAIN TISSUES, A NEW SINGLE CELL ASSAY CAPABLE OF MEASURING MULTIPLE HISTONE MODIFICATIONS, AND PHARMACOLOGICAL PROFILING OF CURRENT ART REGIMENS AND CANNABINOID LEVELS IN BRAIN TISSUES. OUR CENTRAL HYPOTHESIS IS A THERAPEUTIC ROLE OF CANNABINOIDS IN AMELIORATING HIV NEUROPATHOGENESIS IN THE CNS BY ENHANCING THE PROLIFERATION AND SURVIVAL OF NEURAL PROGENITOR CELLS AND IMMATURE NEURONS AND REDUCING GLIAL INFLAMMATION. TO IDENTIFY CELL TYPES, EPIGENETIC CELL STATES, AND GENE PATHWAYS RELEVANT TO NEUROPATHOGENESIS, VIRAL PERSISTENCE, AND CANNABINOID EXPOSURES, WE ARE HARNESSING 180 BRAIN TISSUE SAMPLES FROM AN ESTABLISHED ORAL ADMINISTRATION OF EITHER CANNABIDIOL (CBD) OR 9- TETRAHYDROCANNABINOL (THC) IN NHP AND SINGLE CELL ASSAYS (10X GENOMICS SINGLE NUCLEUS MULTIOME AND A NEW SINGLE CELL ASSAY DEVELOPED AT THE NYGC CAPABLE OF MEASURING THE GENOME-WIDE PRESENCE OF MULTIPLE HISTONE MODIFICATIONS AND PROTEIN-DNA BINDING SITES). MOREOVER, ACCOMPANYING SINGLE CELL DATA WILL BE GENERATED FROM CONSERVED NEUROGENIC BRAIN REGIONS OF HUMAN POSTMORTEM BRAIN TISSUES FROM 40 DONORS BASED ON HIV STATUS (+/-) AND CANNABIS EXPOSURE (+/-). WE WILL ALSO EXPLORE THE FREQUENCY OF SINGLE CELLS IN NEUROGENIC REGIONS OF THE BRAIN THAT ARE INFECTED AND IMPACTED BY CANNABINOIDS BY HARNESSING A BIOINFORMATICS PIPELINE THAT DETECTS BOTH VIRAL TRANSCRIPTS AND TRANSPOSASE ACCESSIBLE PROVIRUS. THIS PROJECT WILL GENERATE COMPREHENSIVE SINGLE CELL DATASETS IN NHP AND HUMANS TO IMPROVE OUR UNDERSTANDING OF THE CROSS TALK BETWEEN HIV AND CANNABINOIDS IN NEUROGENIC REGIONS OF THE BRAIN AND HAS HIGH PROGRAMMATIC PRIORITY TO GOALS OF THE SCORCH PROGRAM EXPANSION.
Department of Agriculture
$9.3M
BREEDING INSIGHT PLATFORM (BIP) INITIATIVE - THE BREEDING INSIGHT PLATFORM (BIP) WILL SUPPORT BREEDING PROJECTS ACROSS ARS BY BUILDING A TEAM OF SPECIALISTS IN INFORMATION TECHNOLOGY, GENOMICS, AND BREEDING PROCESS DESIGN THAT WILL PARTNER WITH INDIVIDUAL ARS PRE-BREEDING AND BREEDING GROUPS. THE INITIAL TWO YEARS WILL FOCUS ON RECRUITING THE BIP TEAM AND INTEGRATING INFORMATICS TOOLS. THE PROJECT WILL LEVERAGE INVESTMENTS IN NINE OPEN SOURCE INFORMATIC TOOLS THAT ARE ALREADY FUNDED BY ARS, CGIAR, USAID, AND BMGF AND BEING DEVELOPED BY SIX INSTITUTIONS. CURRENTLY, THESE NINE TOOLS COVER THE DOMAIN SPACE (VARIOUS ACTIVITIES) NEEDED FOR BREEDING PROGRAMS TO OPERATE EFFICIENTLY, BUT THEY DO NOT INTER-OPERATE WELL. ADDITIONALLY, SOME OF THE TOOLS HAVE BEEN SCALED FOR VERY LARGE PROGRAMS, AND THEY NEED TO BE SIMPLIFIED FOR SMALLER BREEDING PROGRAMS. THE SOFTWARE ENGINEERS WILL IMPROVE AND INTEGRATE THESE TOOLS SO THEY CAN BE APPLIED TO SPECIALTY BREEDING PROGRAMS. INITIALLY, THE PLATFORM WILL ADDRESS FOUR USE CASES: EFFICIENT GENOTYPING, PEDIGREE VERIFICATION, GENOMIC PREDICTION, AND IDENTIFICATION OF NOVEL FAVORABLE VARIANTS. A DIRECTOR, A SOFTWARE DEVELOPMENT TEAM, AND APPLICATION SPECIALIST COORDINATORS WILL LEAD THIS EFFORT FROM ITHACA, NY. IN THE FIRST TWO YEARS, THE PROJECT WILL FOCUS ON FIVE BREEDING PROGRAMS DURING THE PILOT PHASE. IN YEARS 3-5, THE PROJECT IN COLLABORATION WITH ARS COORDINATORS WILL EXPAND ALONG WITH ITS ADVISORY TEAM TO EXTEND THE RESULTS TO ADDITIONAL REMAINING PRE-BREEDING AND BREEDING PROGRAMS. THE SOFTWARE ENGINEERING TEAM IN LATER YEARS WILL FOCUS ON INTEGRATION WITH GERMPLASM COLLECTIONS, SCALING, AND SUPPORT FOR THE WIDE RANGE OF BIOLOGY ENCOUNTERED ACROSS DOZENS OF BREEDING PROGRAMS. THE BREEDING INSIGHT PLATFORM HAS THE POSSIBILITY OF MORE THAN DOUBLING THE EFFICIENCY OF BREEDING PROGRAMS, WHICH WOULD RESULT IN MORE SUSTAINABLE, NUTRITIOUS, PROFITABLE FRUITS, VEGETABLES, AQUACULTURAL SPECIES, AND RANGE LAND PLANTS. THE SHARED OPEN SOURCE PLATFORM WILL ALSO ALLOW INNOVATION AND TALENT TO BE SHARED MUCH MORE WIDELY. THE OPEN SOURCE SOFTWARE SYSTEM DEVELOPED BY THIS PROJECT WILL ALSO HAVE BROAD APPLICABILITY TO NUMEROUS NON-AGRICULTURAL SPECIES, INCLUDING SPECIES CRITICAL FOR ECOLOGY, CONSERVATION BIOLOGY, PATHOLOGY OR ANY GENOMIC DIVERSITY STUDY. THIS PROJECT WILL CONDUCT TRAINING TO ENSURE RESEARCHERS IN OTHER COMMUNITIES CAN USE AND CONTRIBUTE TO THE SOFTWARE PLATFORM. ADDITIONALLY, BECAUSE OF THE TRAINING AND THE PLATFORM'S OPEN SOURCE NATURE IT WILL PROVIDE A CATALYST FOR START-UP COMPANIES AND UNIVERSITY-BASED BREEDING PROGRAMS TO ACCELERATE THEIR EFFORTS.
Department of Health and Human Services
$9.2M
MITOGENIC AND ONCOGENIC REGULATION OF ERK/RSK SIGNALING
Department of Health and Human Services
$9.2M
CORNELL ACISR IN LATE LIFE DEPRESSION
Department of Health and Human Services
$9.2M
IMMUNE CELLS AND SECRETORY PATHWAYS LEADING TO HUMAN SYSTEMIC AUTOIMMUNITY
Department of Agriculture
$9.1M
PROJECT ABSTRACT - CORNELL UNIVERSITY CORNELL COOPERATIVE EXTENSION (CCE) CONNECTS COMMUNITIES WITH CORNELL UNIVERSITY (CORNELL) RESEARCH AND EXPERTISE TO ENRICH AND EMPOWER NEW YORK STATE NEIGHBORS, LOCAL BUSINESSES, TOWNS, AND CITIES. IN NEIGHBORHOODS, HOMES, WORKPLACES, AND SCHOOLS, CCE EDUCATORS WORK TO EMPOWER INDIVIDUALS AND FAMILIES WITH RAISING CHILDREN, SAVING ENERGY AND MONEY, GROWING, AND PREPARING FOOD, STARTING, SUSTAINING BUSINESSES, AND PROTECTING THE ENVIRONMENT. EACH CCE OFFICE RELIES ON COUNTY, STATE, AND FEDERAL FUNDS TO SOLVE LOCAL PROBLEMS AND STRENGTHEN COMMUNITIES. CCE IS COLLABORATIVE BY DESIGN. FROM VOLUNTEERS AND STAFF TO CORNELL FACULTY AND COMMUNITY PARTNERS, CCE WORKS WITH AND WITHIN THE COMMUNITY TO BETTER OUR STATE. CCE PARTNERS WITH LOCAL, STATE, AND FEDERAL GOVERNMENT AGENCIES, WORKING WITH BOTH INNOVATORS AND LAWMAKERS TO AFFECT REAL CHANGE FOR NEW YORK STATE. ACROSS ALL OUR COMMUNITIES, 27,000 NEW YORKERS SPEND THEIR FREE TIME VOLUNTEERING WITH CCE.CCE CONNECTS CORNELL'S WORLD-CLASS FACULTY AND RESEARCH WITH REGIONAL AND COUNTY-BASED EDUCATORS AND PARTNERS ACROSS THE STATE. FACULTY AND STAFF-PRIMARILY FROM THE COLLEGE OF AGRICULTURE AND LIFE SCIENCES AND THE COLLEGE OF HUMAN ECOLOGY-COLLABORATE WITH EXTENSION ASSOCIATES, AGRICULTURE SPECIALISTS, CCE EDUCATORS AND STAFF, LOCAL PARTNERS, AND VOLUNTEERS ACROSS NEW YORK STATE TO ENGAGE AND EMPOWER COMMUNITIES TO TRANSFORM AND GROW. EVERY YEAR CCE TALLIES NEARLY 1.7 MILLION INTERACTIONS WITH NEW YORK RESIDENTS: CHILDREN, FAMILIES, FARMERS, VETERANS, ENTREPRENEURS, COMMUNITY ORGANIZERS, AND MORE, ALL WORKING FOR A BETTER FUTURE. NEARLY 300,000 CHILDREN AND TEENS FROM NEW YORK'S LARGEST CITIES TO SMALLEST TOWNS ARE INVOLVED WITH 4- H, LEARNING SKILLS FOR HEALTHY LIVING, CIVIC ENGAGEMENT, AND SCIENTIFIC DISCOVERY. CCE EXPERTS HELP RESIDENTS RESPOND TO LOCAL CONCERNS. ACROSS NEW YORK, CCE WORKS HARD TO IMPROVE: O FARMING AND FOOD PRODUCTION O PARENTING, FAMILY LIFE, AND FAMILY DYNAMICS OCHILD HEALTH AND NUTRITION O VETERAN AND MILITARY FAMILY OPPORTUNITIES O WATER, LAND AND ENERGY CONSERVATION AND MANAGEMENT O COMMUNITY RESILIENCE O NUTRITION EDUCATION AND HEALTH O FINANCIAL SECURITY AND ECONOMIC VITALITY
Department of Agriculture
$9.1M
CORNELL COOPERATIVE EXTENSION (CCE) CONNECTS COMMUNITIES WITH CORNELL UNIVERSITY (CORNELL) RESEARCH AND EXPERTISE TO ENRICH AND EMPOWER NEW YORK STATE NEIGHBORS, LOCAL BUSINESSES, TOWNS, AND CITIES. IN NEIGHBORHOODS, HOMES, WORKPLACES, AND SCHOOLS, CCE EDUCATORS WORK TO EMPOWER INDIVIDUALS AND FAMILIES WITH RAISING CHILDREN, SAVING ENERGY AND MONEY, GROWING, AND PREPARING FOOD, STARTING, SUSTAINING BUSINESSES, AND PROTECTING THE ENVIRONMENT. EACH CCE OFFICE RELIES ON COUNTY, STATE, AND FEDERAL FUNDS TO SOLVE LOCAL PROBLEMS AND STRENGTHEN COMMUNITIES. CCE IS COLLABORATIVE BY DESIGN. FROM VOLUNTEERS AND STAFF TO CORNELL FACULTY AND COMMUNITY PARTNERS, CCE WORKS WITH AND WITHIN THE COMMUNITY TO BETTER OUR STATE. CCE PARTNERS WITH LOCAL, STATE, AND FEDERAL GOVERNMENT AGENCIES, WORKING WITH BOTH INNOVATORS AND LAWMAKERS TO AFFECT REAL CHANGE FOR NEW YORK STATE. ACROSS ALL OUR COMMUNITIES, 27 ,000 NEW YORKERS SPEND THEIR FREE TIME VOLUNTEERING WITH CCE. CCE CONNECTS CORNELL'S WORLD-CLASS FACULTY AND RESEARCH WITH REGIONAL AND COUNTY-BASED EDUCATORS AND PARTNERS ACROSS THE STATE. FACULTY AND STAFF-PRIMARILY FROM THE COLLEGE OF AGRICULTURE AND LIFE SCIENCES AND THE COLLEGE OF HUMAN ECOLOGY-COLLABORATE WITH EXTENSION ASSOCIATES, AGRICULTURE SPECIALISTS, CCE EDUCATORS AND STAFF, LOCAL PARTNERS, AND VOLUNTEERS ACROSS NEW YORK STATE TO ENGAGE AND EMPOWER COMMUNITIES TO TRANSFORM AND GROW. EVERY YEAR CCE TALLIES NEARLY 1.7 MILLION INTERACTIO NS WITH NEW YORK RESIDENTS: CHILDREN, FAMILIES, FARMERS, VETERANS, ENTREPRENEURS, COMMUNITY ORGANIZERS, AND MORE, ALL WORKING FOR A BETTER FUTURE. NEARLY 300,000 CHILDREN AND TEENS FROM NEW YORK'S LARGEST CITIES TO SMALLEST TOWNS ARE INVOLVED WITH 4-H, LEARNING SKILLS FOR HEALTHY LIVING, CIVIC ENGAGEMENT, AND SCIENTIFIC DISCOVERY. CCE EXPERTS HELP RESIDENTS RESPOND TO LOCAL CONCERNS. ACROSS NEW YORK, CCE WORKS HARD TO IMPROVE - FARMING AND FOOD PRODUCTION; PARENTING, FAMILY LIFE, AND FAMILY DYNAMICS; CHILD HEALTH AND NUTRITION; VETERAN AND MILITARY FAMILY OPPORTUNITIES; WATER, LAND AND ENERGY CONSERVATION AND MANAGEMENT; COMMUNITY RESILIENCE; NUTRITION EDUCATION AND HEALTH; FINANCIAL SECURITY AND ECONOMIC VITALITY.
Department of Agriculture
$9.1M
CORNELL COOPERATIVE EXTENSION (CCE) CONNECTS COMMUNITIES WITH CORNELL UNIVERSITY (CORNELL) RESEARCH AND EXPERTISE TO ENRICH AND EMPOWER NEW YORK STATE NEIGHBORS, LOCAL BUSINESSES, TOWNS, AND CITIES. IN NEIGHBORHOODS, HOMES, WORKPLACES, AND SCHOOLS, CCE EDUCATORS WORK TO EMPOWER INDIVIDUALS AND FAMILIES WITH RAISING CHILDREN, SAVING ENERGY AND MONEY, GROWING, AND PREPARING FOOD, STARTING, SUSTAINING BUSINESSES, AND PROTECTING THE ENVIRONMENT. EACH CCE OFFICE RELIES ON COUNTY, STATE, AND FEDERAL FUNDS TO SOLVE LOCAL PROBLEMS AND STRENGTHEN COMMUNITIES. CCE IS COLLABORATIVE BY DESIGN. FROM VOLUNTEERS AND STAFF TO CORNELL FACULTY AND COMMUNITY PARTNERS, CCE WORKS WITH AND WITHIN THE COMMUNITY TO BETTER OUR STATE. CCE PARTNERS WITH LOCAL, STATE, AND FEDERAL GOVERNMENT AGENCIES, WORKING WITH BOTH INNOVATORS AND LAWMAKERS TO AFFECT REAL CHANGE FOR NEW YORK STATE. ACROSS ALL OUR COMMUNITIES, 27 ,000 NEW YORKERS SPEND THEIR FREE TIME VOLUNTEERING WITH CCE. CCE CONNECTS CORNELL'S WORLD-CLASS FACULTY AND RESEARCH WITH REGIONAL AND COUNTY-BASED EDUCATORS AND PARTNERS ACROSS THE STATE. FACULTY AND STAFF-PRIMARILY FROM THE COLLEGE OF AGRICULTURE AND LIFE SCIENCES AND THE COLLEGE OF HUMAN ECOLOGY-COLLABORATE WITH EXTENSION ASSOCIATES, AGRICULTURE SPECIALISTS, CCE EDUCATORS AND STAFF, LOCAL PARTNERS, AND VOLUNTEERS ACROSS NEW YORK STATE TO ENGAGE AND EMPOWER COMMUNITIES TO TRANSFORM AND GROW. EVERY YEAR CCE TALLIES NEARLY 1.7 MILLION INTERACTIO NS WITH NEW YORK RESIDENTS: CHILDREN, FAMILIES, FARMERS, VETERANS, ENTREPRENEURS, COMMUNITY ORGANIZERS, AND MORE, ALL WORKING FOR A BETTER FUTURE. NEARLY 300,000 CHILDREN AND TEENS FROM NEW YORK'S LARGEST CITIES TO SMALLEST TOWNS ARE INVOLVED WITH 4-H, LEARNING SKILLS FOR HEALTHY LIVING, CIVIC ENGAGEMENT, AND SCIENTIFIC DISCOVERY. CCE EXPERTS HELP RESIDENTS RESPOND TO LOCAL CONCERNS. ACROSS NEW YORK, CCE WORKS HARD TO IMPROVE - FARMING AND FOOD PRODUCTION; PARENTING, FAMILY LIFE, AND FAMILY DYNAMICS; CHILD HEALTH AND NUTRITION; VETERAN AND MILITARY FAMILY OPPORTUNITIES; WATER, LAND AND ENERGY CONSERVATION AND MANAGEMENT; COMMUNITY RESILIENCE; NUTRITION EDUCATION AND HEALTH; FINANCIAL SECURITY AND ECONOMIC VITALITY.
Department of Agriculture
$9.1M
CORNELL COOPERATIVE EXTENSION (CCE) CONNECTS COMMUNITIES WITH CORNELL UNIVERSITY (CORNELL) RESEARCH AND EXPERTISE TO ENRICH AND EMPOWER NEW YORKERS ACROSS THE STATE. CCE PUTS KNOWLEDGE TO WORK IN PURSUIT OF ECONOMIC VITALITY, ECOLOGICAL SUSTAINABILITY AND SOCIAL WELL-BEING. ROOTED IN EVERY COUNTY OF NEW YORK STATE, WE BRING LOCAL EXPERIENCE AND RESEARCH-BASED SOLUTIONS TOGETHER, HELPING FAMILIES AND COMMUNITIES THRIVE IN OUR RAPIDLY CHANGING WORLD. WITH A PRESENCE IN ALL NEW YORK STATE COUNTIES AND THE FIVE BOROUGHS OF NEW YORK CITY, LOCAL CCE OFFICES PROVIDE PROGRAMMING AND RESOURCES TAILORED TO MEET THE NEEDS OF THEIR COMMUNITIES. IN NEIGHBORHOODS, HOMES, WORKPLACES, AND SCHOOLS, CCE EDUCATORS WORK TO EMPOWER INDIVIDUALS AND FAMILIES, WITH RAISING CHILDREN, SAVING ENERGY AND MONEY, GROWING AND PREPARING FOOD, STARTING AND SUSTAINING BUSINESSES, AND PROTECTING THE ENVIRONMENT. EACH CCE OFFICE RELIES ON COUNTY, STATE, AND FEDERAL FUNDS TO SOLVE LOCAL PROBLEMS AND STRENGTHEN COMMUNITIES. CCE IS COLLABORATIVE BY DESIGN. FROM VOLUNTEERS AND STAFF TO CORNELL FACULTY AND COMMUNITY PARTNERS, CCE WORKS WITH AND WITHIN THE COMMUNITY TO BETTER OUR STATE. CCE PARTNERS WITH LOCAL, STATE, AND FEDERAL GOVERNMENT AGENCIES, WORKING WITH BOTH INNOVATORS AND LAWMAKERS TO AFFECT REAL CHANGE FOR NEW YORK STATE. ACROSS ALL OUR COMMUNITIES, 27,000 NEW YORKERS SPEND THEIR FREE ??ME VOLUNTEERING WITH CCE. CCE CONNECTS CORNELL'S WORLD-CLASS FACULTY AND RESEARCH WITH REGIONAL AND COUNTY-BASED EDUCATORS AND PARTNERS ACROSS THE STATE. FACULTY AND STAFF-PRIMARILY FROM THE COLLEGE OF AGRICULTURE AND LIFE SCIENCES AND THE COLLEGE OF HUMAN ECOLOGY-COLLABORATE WITH EXTENSION ASSOCIATES, AGRICULTURE SPECIALISTS, CCE EDUCATORS AND STAFF, LOCAL PARTNERS, AND VOLUNTEERS ACROSS NEW YORK STATE TO ENGAGE AND EMPOWER COMMUNITIES TO TRANSFORM AND GROW. EVERY YEAR CCE TALLIES NEARLY 1.7 MILLION INTERACTIONS WITH NEW YORK RESIDENTS: CHILDREN, FAMILIES, FARMERS, VETERANS, ENTREPRENEURS, COMMUNITY ORGANIZERS, AND MORE, ALL WORKING FOR A BETTER FUTURE. NEARLY 170,000 YOUNG PEOPLE FROM NEW YORK'S LARGEST CI??ES TO SMALLEST TOWNS ARE INVOLVED WITH 4-H, LEARNING SKILLS FOR HEALTHY LIVING, CIVIC ENGAGEMENT, AND SCIENTIFIC DISCOVERY. CCE EXPERTS HELP RESIDENTS RESPOND TO LOCAL CONCERNS. ACROSS NEW YORK, CCE WORKS HARD TO IMPROVE - FARMING AND FOOD PRODUCTION; PAREN??NG, FAMILY LIFE, AND FAMILY DYNAMICS; CHILD HEALTH AND NUTRITION; VETERAN AND MILITARY FAMILY OPPORTUNITIES; WATER, LAND AND ENERGY CONSERVATION AND M ANAGEMENT; COMMUNITY RESILIENCE; NUTRI??ON EDUCATION AND HEALTH; FINANCIAL SECURITY AND ECONOMIC VITALITY.
National Science Foundation
$9M
NEURONEX TECHNOLOGY HUB: OPTICAL TECHNOLOGIES FOR LARGE SCALE, NONINVASIVE RECORDING OF NEURAL ACTIVITY
Department of Health and Human Services
$9M
AN UNDULATOR RESOURCE FOR STRUCTURAL BIOLOGY
Department of Defense
$8.9M
A PHASE 2 STUDY OF INHALED CO FOR THE TREATMENT OF ARDS
Department of Health and Human Services
$8.9M
MECHANISM-BASED TARGETING OF MANTLE CELL LYMPHOMA
Department of Health and Human Services
$8.9M
COMPREHENSIVE CTR OF EXCELLENCE IN DISPARITIES RES & COMMUN ENGAGEMENT (CEDREC)
Department of Health and Human Services
$8.8M
FOREBRAIN PLASTICY IN HYPERTENSION
Department of Health and Human Services
$8.7M
CORNELL ME/CFS COLLABORATIVE RESEARCH CENTER
National Science Foundation
$8.7M
FRONTIER RESEARCH AT THE JICAMARCA RADIO OBSERVATORY -THE IONIZED PORTION OF THE UPPER ATMOSPHERE AT THE MAGNETIC EQUATOR (EQUATORIAL IONOSPHERE) IS A UNIQUE PLASMA ENVIRONMENT WHICH HOSTS DIVERSE PLASMA PHENOMENA RANGING FROM EQUATORIAL PLASMA BUBBLES TO SMALL-SCALE PLASMA STRUCTURES. PLASMA BUBBLES AND OTHER PLASMA DENSITY STRUCTURES ARE KNOWN TO DISTURB RADIO AND SATELLITE COMMUNICATIONS AND THUS REPRESENT A SPACE WEATHER HAZARD. THE JICAMARCA RADIO OBSERVATORY (JRO) NEAR LIMA, PER? HAS BEEN PROVIDING HIGH-QUALITY OBSERVATIONS OF THESE PHENOMENA AND THE ASSOCIATED PLASMA PROCESSES FOR 60 YEARS. JRO IS OWNED AND OPERATED BY THE PERUVIAN GEOPHYSICAL INSTITUTE (INSTITUTO GEOF?SICO DEL PER?) WITH SUPPORT FROM AN AWARD FROM THE GEOSPACE FACILITIES PROGRAM AT NSF TO CORNELL UNIVERSITY. JRO IS THE EQUATORIAL ANCHOR OF THE GEOSPACE FACILITIES CHAIN AND THE ONLY SUCH FACILITY THAT ENABLES EXPERIMENTAL INVESTIGATIONS OF SPACE PLASMA PHYSICS AND SPACE WEATHER DISTURBANCES NEAR THE MAGNETIC EQUATOR. OVER THE YEARS, JRO HAS UNDERGONE CONTINUAL IMPROVEMENT AND UPGRADES AND ITS CENTERPIECE, THE JICAMARCA INCOHERENT SCATTER RADAR (ISR), IS CURRENTLY THE LARGEST ISR IN TERMS OF THE POWER-APERTURE PRODUCT, A MEASURE OF HOW SENSITIVE THE RADAR IS TO VARIOUS PLASMA DISTURBANCES. THE WORK WILL EXPLOIT THE JRO?S UNIQUE CAPABILITIES ASSOCIATED WITH ITS LOCATION NEAR THE MAGNETIC EQUATION AND ITS HIGH SENSITIVITY BY FOCUSING ON NEW CLASSES OF PLASMA PHENOMENA AND PROCESSES UNIQUE TO THE EQUATORIAL ZONE. THESE INCLUDE UPPER-HYBRID PLASMA INSTABILITY IN THE DAYTIME 150-KM REGION, LOWER-HYBRID WAVES IN THE HIGH TOPSIDE AT NIGHT, SOLAR ECHO EXPERIMENTS, MULTI-FREQUENCY PLASMA IRREGULARITY STUDIES, THE EFFECTS OF COULOMB COLLISIONS ON THE INCOHERENT RADAR SPECTRUM, AND METEOR ECHOES AND DERIVED NEUTRAL WINDS. THIS WORK WILL EXPAND RELATIONSHIPS WITH OUTSIDE RESEARCHERS AND PROGRAMS THROUGH COLLABORATIVE INVESTIGATIONS AND BY HOSTING VISITS FROM STUDENTS AND PROFESSIONALS; MAINTAIN AN EFFICIENT, DIVERSE MANAGEMENT SYSTEM THAT IS RESILIENT TO CHANGES OCCURRING AT NSF, CORNELL, AND IN PERU; EXPAND STEM EDUCATIONAL OPPORTUNITIES BY DIRECTLY SUPPORTING UNDERGRADUATE AND GRADUATE STUDENTS; AND TRAIN THE NEXT GENERATION OF RADIO SCIENTISTS THROUGH A COMBINATION OF SUMMER SCHOOLS, WORKSHOPS, AND HOSTED VISITS AS WELL AS THE CREATION OF CURRICULA AND EDUCATIONAL MATERIALS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
Department of Health and Human Services
$8.6M
NEW MECHANISMS AND TECHNOLOGIES FOR UNDERSTANDING POST-TRANSCRIPTIONAL GENE REGULATION IN NEURONS
Department of Health and Human Services
$8.5M
CELL SIGNALING AND CELL DECISIONS
Department of Health and Human Services
$8.5M
MULTI-SCALE MODEL OF THORMBOSIS IN ARTIFICIAL CIRCULATION
Department of Health and Human Services
$8.5M
RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
Department of Health and Human Services
$8.3M
REASONS FOR GEOGRAPHIC AND RACIAL DIFFERENCES IN STROKE-MYOCARDIAL INFARCTION-4 (REGARDS-MI-4) - BLACK-WHITE CORONARY HEART DISEASE (CHD) AND HEART FAILURE (HF) DISPARITIES PERSIST IN THE US DESPITE DECADES OF RESEARCH AND NATIONAL PUBLIC HEALTH CAMPAIGNS. THE ROLE OF SOCIAL DETERMINANTS OF HEALTH (SDH) LIKE STRUCTURAL RACISM IN HEALTH DISPARITIES HAS BEEN STUDIED IN ONLY 1% OF PUBLISHED WORK. FEW STUDIES OF SDH HAVE TAKEN A LIFE COURSE PERSPECTIVE RELATED TO RISK OF CHD AND HF. THE ABILITY TO RECOVER AFTER THE STRESS OF AN ACUTE HEALTH EVENT, OR RESILIENCE, IS AN IMPORTANT PATIENT-CENTERED OUTCOME, BUT THE INFLUENCE OF SDH ON RESILIENCE IS UNKNOWN. FEW PAST STUDIES HAVE EXAMINED BOTH STRUCTURAL AND INTERMEDIARY SDH IN THE WORLD HEALTH ORGANIZATION'S (WHO) COMMISSION ON SDH (WHOCSD) CONCEPTUAL FRAMEWORK IN A LONGITUDINAL NATIONAL SAMPLE WITH RIGOROUSLY ADJUDICATED CHD AND HF ENDPOINTS, WHICH IS ONE OF THE AIMS OF THIS APPLICATION. WE PROPOSE A SERIES OF STUDIES TO FILL THESE GAPS, WHILE ALSO PROVIDING RIGOROUSLY ADJUDICATED CHD AND HF EVENTS AND CAUSES OF DEATH TO A HOST OF INVESTIGATORS INTERESTED IN USING THESE DATA (TO DATE, OVER 500 HAVE USED THESE DATA). WE BUILD ON A TRACK RECORD OF MENTORING TO PROPOSE A FORMAL YEAR-LONG CAREER DEVELOPMENT PROGRAM FOR EARLY-STAGE INVESTIGATORS (ESI), ESPECIALLY UNDERREPRESENTED MINORITIES (URM). THE SPECIFIC AIMS OF THIS APPLICATION ARE TO: (AIM 1) CONDUCT STUDIES EXAMINING UNDERLYING MECHANISMS OF HEALTH DISPARITIES, GUIDED BY THE WHOCSD CONCEPTUAL FRAMEWORK, IN THREE THEMATIC AREAS: A) THE INCIDENCE AND RECURRENCE OF CHD; B) THE INCIDENCE AND RECURRENCE OF HF WITH PRESERVED EJECTION FRACTION AND HF WITH REDUCED EJECTION FRACTION; C) RESERVE AND RESILIENCE AFTER AN INCIDENT OR RECURRENT CHD OR HF EVENT. (AIM 2) TO CONTINUE TO ADJUDICATE CHD EVENTS, HF HOSPITALIZATIONS, AND CAUSES OF DEATH TO SUPPORT A WIDE RANGE OF STUDIES BY INVESTIGATORS BEYOND OUR GROUP, AND TO LINK THE COHORT WITH MEDICARE DATA TO SUPPORT INVESTIGATORS CONDUCTING HEALTH SERVICES UTILIZATION STUDIES. (AIM 3) TO SUPPORT THE DEVELOPMENT OF RESEARCHERS IN CVD HEALTH EQUITY, ESPECIALLY URMS, THROUGH A NEW MENTORED RESEARCH PROGRAM FOR A COHORT OF EARLY STAGE INVESTIGATORS, INCLUDING ANALYTIC AND STATISTICAL SUPPORT AND AN ANNUAL 2-DAY HEALTH EQUITY RESEARCH SUMMER INSTITUTE OF PRESENTATIONS, TRAINING, MOCK STUDY SECTION, AND NETWORKING. EARLY STAGE INVESTIGATORS WILL GRADUATE WITH SPECIFIC COMPETENCIES IN CVD HEALTH EQUITY RESEARCH. THE PROPOSED GRANT WILL INFORM POLICY, ADVOCACY, AND THE DESIGN OF INTERVENTIONS BY GENERATING NEW EVIDENCE ON WHICH SDH AND DISPARITIES IN HEALTH SERVICES LEAD TO POPULATION-LEVEL DISPARITIES IN INCIDENT AND RECURRENT CHD AND HF, AND ON RESILIENCE IN RECOVERY AFTER A CHD OR HF EVENT. OUR MULTIDISCIPLINARY TEAM INCLUDES EPIDEMIOLOGISTS, SOCIOLOGISTS, HEALTH SERVICES RESEARCHERS, BIOSTATISTICIANS, CLINICIANS, AND A PARTICIPANT ADVISORY BOARD, ASSURING RIGOR AND RELEVANCE OF THE PROPOSED RESEARCH. CONTINUED FUNDING FOR THE REGARDS-MI INFRASTRUCTURE WILL SUPPORT A HOST OF ADDITIONAL STUDIES LED BY AN EXPANDING GROUP OF INVESTIGATORS. FUNDING WILL ALSO EXPAND THE CADRE OF RESEARCHERS DEDICATED TO DISCOVERING STRATEGIES TO ACHIEVE HEALTH EQUITY FOR ALL US ADULTS, A GOAL SUPPORTED BY NHLBI, THE NATIONAL ACADEMY OF SCIENCES, THE CDC, THE AMERICAN HEART ASSOCIATION, AND ALL MAJOR PROFESSIONAL SOCIETIES IN THE US.
National Science Foundation
$8.3M
NEW FRONTIERS AT THE JICAMARCA RADIO OBSERVATORY: THE BEGINNING OF SOLAR CYCLE 24
National Science Foundation
$8.2M
CC*DNI DIBBS: DATA ANALYSIS AND MANAGEMENT BUILDING BLOCKS FOR MULTI-CAMPUS CYBERINFRASTRUCTURE THROUGH CLOUD FEDERATION
Department of Health and Human Services
$8.2M
CORNELL ME/CFS COLLABORATIVE RESEARCH CENTER - PROJECT SUMMARY: OVERALL DESPITE THE ENORMOUS SUFFERING ENDURED BY MILLIONS OF PEOPLE WORLDWIDE, THE UNDERLYING CAUSES OF MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (ME/CFS) ARE UNKNOWN AND EFFECTIVE THERAPIES ARE LACKING. ME/CFS IS CHARACTERIZED BY DEBILITATING FATIGUE, MUSCULOSKELETAL PAIN, HEADACHES, COGNITIVE DIFFICULTIES ORTHOSTATIC INTOLERANCE, AND SLEEP DISTURBANCES. THE ABSENCE OF SIMPLE OBJECTIVE TESTS PREVENTS MANY FROM OBTAINING AN APPROPRIATE DIAGNOSIS AND INHIBITS DRUG DEVELOPMENT BECAUSE OF THE LACK OF BIOMARKERS TO MONITOR THE EFFICACY OF EXPERIMENTAL THERAPIES. IN ORDER TO GAIN FUNDAMENTAL MECHANISTIC INSIGHTS INTO ME/CFS, WE WILL LEVERAGE THE EXPERIENCE, CAPABILITIES AND VARIED BACKGROUNDS OF RESEARCHERS FROM FOUR DIFFERENT COLLEGES AT CORNELL UNIVERSITY, FLORIDA ATLANTIC UNIVERSITY, THE HOSPITAL FOR SPECIAL SURGERY, AND AN ME/CFS EXPERT PHYSICIAN. WE WILL TAKE ADVANTAGE OF AN ENORMOUS AMOUNT OF DATA ALREADY OBTAINED FROM PATIENTS AND CONTROLS BOTH BEFORE AND AFTER SYMPTOM PROVOCATION THROUGH EXERCISE, AS WELL AS A VALUABLE SET OF NEW SAMPLES. THREE RESEARCH PROJECTS WILL SEEK TO (1) USE CUTTING-EDGE MULTI-OMIC SINGLE CELL PROFILING TO EXAMINE ALTERATIONS IN CELL TYPES, GENE EXPRESSION, AND CELL-CELL INTERACTIONS THAT OCCUR IN ME/CFS MUSCLE (PROJECT 1), (2) IDENTIFY TISSUE INJURED IN ME/CFS FOLLOWING EXERCISE THROUGH CHARACTERIZATION OF RNA RELEASED INTO CIRCULATION AND (3) IDENTIFY THE RNA AND PROTEIN CARGO OF EXTRACELLULAR VESICLES IN ME/CFS PATIENTS THAT MAY ALTER FUNCTION OF TARGET CELLS (PROJECT 2) AND (4) USE GENOMIC AND COMPUTATIONAL METHODS TO BETTER UNDERSTAND THE GENE REGULATORY MECHANISMS THAT RESULT IN IMMUNE DYSREGULATION IN ME/CFS AND SYSTEMATICALLY IDENTIFY ME/CFS-SPECIFIC ALTERATIONS IN SIGNALING ACROSS THE IMMUNE SYSTEM (PROJECT 3). THESE THREE RESEARCH PROJECTS ARE SUPPORTED BY A RESEARCH CORE THAT WILL ACT AS A RESOURCE FOR GENOMICS TECHNOLOGY EXPERTISE, REAGENTS, AND SERVICES AND FOR DATA MANAGEMENT AND INTEGRATED ANALYSIS. MULTI-OMIC ANALYSIS AND PREDICTIVE MODELING CARRIED OUT IN ALL THREE PROJECTS WILL PROVIDE A FOUNDATION FOR FUTURE DEVELOPMENT OF THERAPEUTICS AND DIAGNOSTIC TESTS. ALL CENTER ACTIVITIES WILL BE COORDINATED THROUGH AN ADMINISTRATIVE CORE, WHICH WILL FOSTER SYNERGY AND INTEGRATION WITHIN THE CENTER, WHILE ALSO BEING THE PLATFORM FOR COLLABORATION WITH OTHER ME/CFS COLLABORATIVE RESEARCH CENTERS, A PATIENT/ADVOCATE/CAREGIVER COMMITTEE, OTHER ME/CFS RESEARCHERS, AND THE DATA MANAGEMENT COORDINATING CENTER. THE ADMINISTRATIVE CORE WILL ALSO BE RESPONSIBLE FOR OUTREACH ACTIVITIES THAT ARE DESIGNED TO INCREASE AWARENESS AND UNDERSTANDING OF ME/CFS WITHIN THE RESEARCH COMMUNITY, HEALTH PROFESSIONALS, AND THE GENERAL PUBLIC, AND WILL ADMINISTER A PILOT PROJECT PROGRAM DESIGNED TO BRING NEW IDEAS AND RESEARCHERS INTO THE ME/CFS FIELD.
Department of Defense
$8.2M
MULTIPHYSICS CONTROL OF SPRAY FORMATION AND DISPERSION
National Science Foundation
$8.2M
NNCI: CORNELL NANOSCALE SCIENCE AND TECHNOLOGY FACILITY (CNF)
Department of Health and Human Services
$8.2M
THE ORIGIN, PREDICTORS, AND IMMUNE CORRELATES OF VIRAL REBOUND IN ORALLY SHIV INFECTED INFANT MONKEYS
Department of Health and Human Services
$8.1M
SPERMATOGENIC GENE REGULATION AND INFERTILITY - THE CORNELL CENTER FOR REPRODUCTIVE GENOMICS (CRG) WAS FOUNDED IN 2007 WITH THE GOAL OF LEVERAGING STATE-OF- THE-ART GENOMICS TECHNOLOGIES FOR UNDERSTANDING THE BIOLOGY OF THE MAMMALIAN GERM CELL. MORE SPECIFICALLY, OUR GOAL HAS BEEN TO UNDERSTAND THE GENETIC, EPIGENETIC, AND EPITRANSCRIPTOMIC BASIS FOR THE GENERATION OF VIABLE HEALTHY GAMETES AND TO EXPLORE HOW ALTERATIONS IN THESE EVENTS COULD CONTRIBUTE TO HUMAN INFERTILITY. IT IS WELL KNOWN THAT DISRUPTION OF GENES REQUIRED FOR REGULATING ALL ASPECTS OF GENE EXPRESSION, INCLUDING CHROMATIN MODIFIERS, THE TRANSCRIPTION MACHINERY, AND COMPONENTS OF POST-TRANSCRIPTIONAL REGULATORY PATHWAYS, LEADS TO THE FORMATION OF SPERMATOZOA WITH ABNORMAL HEAD MORPHOLOGY IN THE MOUSE, WHILE SPERM FROM MEN WITH INCREASED ABNORMAL SPERM MORPHOLOGY SIGNIFICANTLY HIGHER RATES OF CHROMOSOMAL ANEUPLOIDY, CHROMATIN COMPACTION DEFECTS, AND ALTERED TRANSCRIPTOME PROFILES COMPARED TO SPERM FROM FERTILE MEN. THUS, IN THIS APPLICATION, WE SEEK TO UNDERSTAND HOW TRANSCRIPTIONAL, POST-TRANSCRIPTIONAL, AND EPITRANSCRIPTOMIC REGULATION OF GENE EXPRESSION AND CHROMATIN STATE CONTRIBUTES TO THE DIFFERENTIATION OF HAPLOID GERM CELLS INTO MATURE SPERMATOZOA. THREE PROJECTS ARE PROPOSED AND THREE CORES ARE PROPOSED. PROJECT I (DANKO AND COHEN) WILL FOCUS ON THE IMPORTANCE OF TRANSCRIPTIONAL REGULATION OF GENE EXPRESSION AT THE EXIT FROM MEIOSIS AND ENTRY INTO SPERMIOGENESIS, WITH A FOCUS ON THE ROLE OF THE BROMODOMAIN PROTEIN, BRDT IN FACILITATING TRANSCRIPTIONAL SHUTDOWN AND THUS PERMITTING APPROPRIATE HISTONE-TO-PROTAMINE REPLACEMENT AND NUCLEAR COMPACTION. PROJECT II (GRIMSON, SCHIMENTI, HWANG) WILL FOCUS ON MECHANISMS AND FUNCTIONS OF POST-TRANSCRIPTIONAL PROCESSING AND REGULATION OF MRNAS DURING SPERMIOGENESIS AND WHETHER DEFECTS IN THESE PROCESSES CAN UNDERLIE DEFECTS IN SPERM MORPHOLOGY IN PATIENTS SEEKING ASSISTED REPRODUCTIVE TECHNOLOGIES. PROJECT III (JAFFREY) WILL EXPLORE THE DYNAMICS OF N6-METHYLADENOSINE (M6A) AND N6, 2’-O-DIMETHYLADENOSINE (M6AM) MODIFICATIONS ON RNA THROUGH SPERMATOGENESIS IN MICE AND IN MEN, AND THE IMPORTANCE OF THESE EPITRANSCRIPTOMIC CHANGES FOR THE PRODUCTION OF HEALTHY SPERM IN MICE AND MEN. THESE STUDIES WILL BE SUPPORTED BY A WELL-ESTABLISHED ADMINISTRATIVE CORE (COHEN) THAT WILL FACILITATE CLOSE INTERACTIONS THROUGH REGULAR MEETINGS, TRAINEE EVENTS, PILOT AND SEED GRANTS, AND OUR POPULAR “TRI-REPRO” ANNUAL SYMPOSIUM. OUR STATE-OF- THE-ART GENOME INNOVATION CORE (GRENIER) WILL SERVE AS AN INNOVATION HUB FOR EXPLORING ALL ASPECTS OF GENE REGULATION IN REPRODUCTION, SPECIALIZING IN A RANGE OF NEXT GENERATION SEQUENCING TECHNOLOGIES TO SUPPORT THE PROJECTS. FINALLY, OUR OUTREACH CORE (LIN) WILL PROVIDE LAB OPPORTUNITIES FOR NEARBY, AND TRADITIONALLY UNDERSERVED, SCHOOL DISTRICTS THROUGHOUT UPSTATE NEW YORK, AT THE SAME TIME SENDING OUR TRAINEES AND FACULTY OUT TO THESE COMMUNITIES AS ROLE MODELS FOR YOUNG BUDDING SCIENTISTS. OUR CENTER WILL BENEFIT FROM THE STRONG RESEARCH AND CLINICAL INTEGRATION WE HAVE ESTABLISHED OVER THE PAST 13 YEARS, BY ROBUST AND UNEQUIVOCAL INSTITUTIONAL SUPPORT, AND BY THE OUTSTANDING SCIENTIFIC ENVIRONMENT PROVIDED BY CORNELL UNIVERSITY.
National Science Foundation
$8.1M
COLLABORATIVE RESEARCH: COMPSUSTNET: EXPANDING THE HORIZONS OF COMPUTATIONAL SUSTAINABILITY
Agency for International Development
$8.1M
AGRICULTURE EDUCATION AND INNOVATION SYSTEMS PROJECT
Department of Health and Human Services
$8M
MODERNIZATION AND EXPANSION OF THE CITIGROUP BIOMEDICAL IMAGING CENTER AT WEILL CORNELL MEDICAL COLLEGE - ABSTRACT THE PROPOSED PROJECT INVOLVES MAJOR MODERNIZATION AND FOCUSED CONSTRUCTION AT THE RAPIDLY GROWING CITIGROUP BIOMEDICAL IMAGING CENTER (CBIC) OF WEILL CORNELL MEDICAL COLLEGE IN MANHATTAN, NEW YORK CITY. THE CBIC IS A COMPREHENSIVE IMAGING RESEARCH RESOURCE DEDICATED TO THE DEVELOPMENT OF NEW BIOMEDICAL IMAGING TECHNIQUES IN SUPPORT OF A WIDE RANGE OF INVESTIGATORS ENGAGED IN THE DIAGNOSIS AND TREATMENT OF HUMAN DISEASE. SINCE ITS INCEPTION IN 2001, THE CBIC HAS ROUTINELY SERVED OVER 100 PRINCIPAL INVESTIGATORS FROM MORE THAN 10 INSTITUTIONS IN ANY GIVEN YEAR (148 GROUPS FROM 14 INSTITUTIONS IN 2022, OUR LARGEST USAGE EVER). THE RESEARCH SUPPORTED BY THE CBIC HAS BOTH A NATIONAL AND INTERNATIONAL IMPACT DUE TO THE MANY INVESTIGATORS WHO ARE LEADERS IN THEIR RESPECTIVE DISCIPLINES, LEAD LARGE MULTI-INSTITUTIONAL RESEARCH PROJECTS, INVENT NEW IMAGING TECHNIQUES, AND RECRUIT HUMAN SUBJECTS WORLDWIDE. THE RANGE OF PROJECTS SUPPORTED WITH CBIC IMAGING RESOURCES IS EXTREMELY BROAD, AND INCLUDES STUDIES IN NEUROSURGERY, PSYCHIATRY, NEURODEGENERATIVE DISEASE, ONCOLOGY, ORTHOPEDICS, GENETIC MEDICINE, AND STRUCTURAL BIOLOGY. THE ANNUAL TOTAL COSTS OF NIH GRANTS THAT ARE SUPPORTED TYPICALLY EXCEEDS $50 MILLION. IN 2022, A RECORD 172 NIH FUNDED PROJECTS WERE SUPPORTED BY CBIC WITH TOTAL COSTS OF OVER $118 MILLION. THE CENTER OFFERS TEN MAJOR IMAGING AND SPECTROSCOPY PLATFORMS FOR BOTH HUMAN AND PRE-CLINICAL STUDIES, INCLUDING MAGNETIC RESONANCE IMAGING (MRI) AND SPECTROSCOPY, POSITRON EMISSION TOMOGRAPHY (PET), COMPUTED TOMOGRAPHY (CT), SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY, ULTRASOUND, AND OPTICAL IMAGING. IN ADDITION, COMPLETE CYCLOTRON AND RADIOCHEMISTRY FACILITIES ARE AVAILABLE. WE HAVE NOW SURPASSED THE 20-YEAR MARK SINCE THE CENTER WAS ESTABLISHED, AND WE HAVE AN URGENT NEED FOR MAJOR MODERNIZATION AND CONSTRUCTION OF INFRASTRUCTURE IN ORDER TO CONTINUE TO PROVIDE A SAFE, STATE-OF-THE-ART ENVIRONMENT FOR IMAGING STUDIES INVOLVING BOTH HUMAN SUBJECTS AND ANIMAL MODELS OF DISEASE FOR OUR RAPIDLY INCREASING POOL OF INVESTIGATORS. IN ORDER TO MEET OUR PRESENT AND FUTURE NEEDS, WE PROPOSE THE FOLLOWING FIVE PROJECT COMPONENTS: 1) CONSTRUCTION OF A NEW POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY (PET/CT) SUITE, FACILITATING WHOLE-BODY PET FOR THE FIRST TIME, 2) CONSTRUCTION OF A NEW MODERN HIGH FIELD NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY SUITE FOR OUR THREE HIGH FIELD NMR SPECTROMETERS, 3) RENOVATION OF OUR RADIOPHARMACEUTICAL PRODUCTION SUITE, ALLOWING US TO SEPARATE RADIOCHEMISTRY NEEDED FOR PRODUCTION OF OUR HIGH DEMAND CARBON-11 LABELED RADIOTRACERS FROM THAT OF TRACERS PRODUCED WITH OTHER RADIOISOTOPES, 4) INSTALLATION OF TANK MANIFOLDS AND SUPPLY LINES TO ENABLE GENERAL ANESTHESIA CAPABILITY, ALLOWING US TO ACCEPT A WIDER RANGE OF RESEARCH SUBJECTS THAN IS CURRENTLY POSSIBLE, 5) ADDITION OF ELECTRICAL INFRASTRUCTURE TO TWO KEY SCANNERS (ONE MRI AND ONE PET) TO ENSURE THAT TRANSIENT POWER INTERRUPTIONS ARE MINIMIZED, THEREBY SIGNIFICANTLY INCREASING THE SAFETY OF ONGOING AND ANTICIPATED IMAGE- GUIDED THERAPEUTIC INTERVENTIONS.
Department of Health and Human Services
$8M
OVEREXPRESSION OF APP AND CEREBROVASCULAR REGULATION
National Science Foundation
$7.9M
COLLABORATIVE RESEARCH: COMPUTATIONAL SUSTAINABILITY: COMPUTATIONAL METHODS FOR A SUSTAINABLE ENVIRONMENT, ECONOMY, AND SOCIETY
Department of Health and Human Services
$7.9M
MACROMOLECULAR DIFFRACTION RESOURCE: MACCHESS
Department of Health and Human Services
$7.9M
A PRACTICAL MICROBICIDE BASED ON HIV-1 ENTRY INHIBITORS
National Science Foundation
$7.8M
NSDL TECHNICAL NETWORK SERVICES: A CYBERINFRASTRUCTURE PLATFORM FOR STEM EDUCATION
Department of Energy
$7.8M
GROUND-TRUTHING: EXPLORATORY BOREHOLE CHARACTERIZATION AND MODELING TO VERIFY AND EXPAND TECHNO-ECONOMIC EVALUATION OF EARTH SOURCE HEAT AT CORNELL UNIVERSITY
Department of Energy
$7.7M
CREATING NEW QUANTUM STATES OF MATTER IN TIME AND SPACE THROUGH ENGINEERING ARTIFICIAL INTERFACES AND STRUCTURES
Department of Health and Human Services
$7.7M
A LONGITUDINAL COHORT STUDY TO EVALUATE CARDIOVASCULAR RISK FACTORS AND DISEASE IN HAITI
Department of Health and Human Services
$7.6M
BACILLUS SUBTILIS STRESS RESPONSES
Department of Health and Human Services
$7.6M
DISRUPTED ADENOVIRUS SEROTYPE 5-BASED ANTI-COCAINE VACCINE
National Science Foundation
$7.6M
GENETIC NETWORKS REGULATING STRUCTURE AND FUNCTION OF THE MAIZE SHOOT APICAL MERISTEM
National Science Foundation
$7.5M
NNCI: CORNELL NANOSCALE SCIENCE AND TECHNOLOGY FACILITY (CNF)
Department of Health and Human Services
$7.5M
STRUCTURE AND FUNCTION OF NEUROTRANSMITTER TRANSPORTERS
Department of Defense
$7.5M
TAS::57 3600::TAS '(MURI) SCIENTIFIC AUTONOMOUS REASONING AGENT (SARA): INTERGRATING MATERIALS THEORY, EXPERIMENTAL AND COMPUTATION'
Department of Defense
$7.5M
TAS::57 3600::TAS "(MURI 15)- ATOMICALLY-THIN SYSTEMS THAT UNFOLD, INTERACT AND COMMUNICATE AT THE CELLULAR SCALE", DATED, 23 FEB 2015 (THE GRANTEE'S
Department of Defense
$7.5M
PERISCOPE: PERCEPTUAL REPRESENTATIONS FOR ACTIONS, COMPOSITION, AND VERIFICATION
Department of Defense
$7.5M
MURI-18 HYBRID-MATERIALS VALLEY OPTOELECTRONICS FOR PHOTON SPIN COMMUNICATION ** FAADC MIGRATION NOTE - ACTION TYPE:"1" TO "A", RECORD TYPE:"2", BUSINESS FUNDS INDICATOR:"NON", INDIVIDUAL RECIPIENT INDICATOR:"NO", RESEARCH AND DEVELOPMENT FUNDS INDICATOR:"YES", COMPETED OPPORTUNITY:"1" TO "C", NUMBER OF PROPOSALS OR APPLICATIONS:"1", AWARDING SUB-TIER AGENCY CODE "5700" DERIVED FROM AWARDING OFFICE CODE "FA9550", FUNDING SUB-TIER AGENCY CODE "5700" DERIVED FROM FUNDING OFFICE CODE "F4FGA0", PPOP COUNTRY CODE:"USA", SMALL BUSINESS INDICATOR:"O", SAM EXCEPTION:"X" **
Department of Health and Human Services
$7.5M
SYSTEMATIC ANALYSIS OF C ELEGANS LONGEVITY DETERMINANTS
Department of Health and Human Services
$7.4M
SMALL RNA PATHWAYS IN MAMMALIAN GAMETOGENESIS
National Science Foundation
$7.4M
SPACE WEATHER RESEARCH AT THE JICAMARCA RADIO OBSERVATORY
Department of Health and Human Services
$7.3M
PREDOCTORAL TRAINING IN CELLULAR AND MOLECULAR BIOLOGY
Environmental Protection Agency
$7.3M
DESCRIPTION:THE PURPOSE OF THIS AGREEMENT IS TO PROVIDE ASSISTANCE TO THE CORNELL UNIVERSITY OFFICE OF SPONSORED PROGRAMS TO IMPLEMENT ITS PROJECT TO SUPPORT THE LONG ISLAND SOUND COMPREHENSIVE CONSERVATION AND MANAGEMENT PLAN TO PROTECT AND RESTORE LONG ISLAND SOUND BY PROVIDING OUTREACH AND EDUCATION TO THE PUBLIC ON ENVIRONMENTAL STEWARDSHIP AND TO PROVIDE TECHNICAL ASSISTANCE TO STATE AND LOCAL GOVERNMENTS ON SUSTAINABILITY AND CLIMATE RESILIENCY. ACTIVITIES:SPECIFICALLY, UNDER THIS COOPERATIVE AGREEMENT THE RECIPIENT WILL 1) CONDUCT PUBLIC ENVIRONMENTAL EDUCATION AND INVOLVEMENT PROGRAMS FOR THE LONG ISLAND SOUND IN THE STATE OF NEW YORK; AND 2) PROVIDE TECHNICAL ASSISTANCE TO SUPPORT SUSTAINABLE AND RESILIENT COMMUNITIES.SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:UNDER THIS COOPERATIVE AGREEMENT, THE ANTICIPATED DELIVERABLES FOR THE FIRST ACTIVITY ARE TO: CONDUCT TWO WORKSHOPS FOR TEACHERS; PUBLISH THE SOUND UPDATE NEWSLETTER; PROVIDE INFORMATION THROUGH MULTIPLE COMMUNICATIONS PRODUCTS; ORGANIZE CITIZENS ADVISORY COMMITTEE MEETINGS; SUPPORT THE WORK OF OTHER LONG ISLAND SOUND STUDY WORK GROUPS; CONDUCT VOLUNTEER OPPORTUNITIES AT STEWARDSHIP SITES; AND SUPPORT THREE TRAININGS AIMED AT INCREASING LISS PARTNERS' UNDERSTANDING OF DIVERSITY, EQUITY, INCLUSION, AND JUSTICE TERMINOLOGY, HISTORY AND PRACTICES. THE ANTICIPATED DELIVERABLES FOR THE SECOND ACTIVITY ARE TO ADVANCE SUSTAINABILITY AND RESILIENCE BY LOCAL GOVERNMENTS, DEVELOP TRAINING PROGRAMS BASED ON THE NEEDS ASSESSMENT, HOLD A BI-STATE WORKSHOP, DEVELOP A CLEARINGHOUSE OF TOOLS AND RESOURCES, IMPROVE COORDINATION AMONG LEVELS OF GOVERNMENT, AND INCREASE IMPLEMENTATION OF LONG ISLAND SOUND SUSTAINABILITY AND RESILIENCE PROJECTS. THE BENEFICIARIES AND OUTCOMES OF THIS WORK WILL BE RESIDENTS WITH AWARENESS, KNOWLEDGE, AND SKILLS TO PROTECT LONG ISLAND SOUND, POLICY MAKERS AND STAKEHOLDERS HAVING INFORMATIONAL RESOURCES TO COLLABORATE; SUSTAINABLE AND RESILIENT NEW AND EXISTING DEVELOPMENT; AN EDUCATED PUBLIC INVOLVED IN ENVIRONMENTAL RESTORATION AND PROTECTION; ACTIONS IMPLEMENTED THROUGH COORDINATED STRATEGIES BY ALL LEVELS OF GOVERNMENT AND DIVERSE STAKEHOLDERS; AND IMPLEMENTATION ADAPTED AND IMPROVED THROUGH APPLICATION OF NEW INFORMATION AND KNOWLEDGE.
Department of Health and Human Services
$7.2M
SYNAPTIC MECHANISMS OF GENERAL ANESTHETIC ACTION
Department of Health and Human Services
$7.2M
TARGETING EPIGENETIC CIRCUITS IN B-CELL LYMPHOMAS
Department of Health and Human Services
$7.1M
MOLECULAR MECHANISMS OF SIGNAL TRANSDUCTION INVOLVING LIGHT, REDOX AND TRANSMEMBRANE COMPLEXES
Department of Health and Human Services
$7.1M
ADAPTABLE TISSUE-SPECIFIC ENDOTHELIAL CELLS FOR ORGAN REGENERATION
Department of Health and Human Services
$7.1M
EFFECTS OF COENZYME Q10 IN PARKINSON DISEASE-PHASE 3
Agency for International Development
$7.1M
AGRICULTURAL BIOTECHNOLOGY SUPPORT PROGRAM II
Department of Health and Human Services
$7M
STRENGTHENING TRAINING, EVALUATION, AND PARTNERSHIPS IN THE PREVENTION AND CONTROL OF VECTOR-BORNE DISEASES - THE NEW ENGLAND AND MIDDLE-ATLANTIC REGIONS OF THE UNITED STATES FACE SOME OF THE GREATEST VECTOR-BORNE DISEASE CHALLENGES IN THE NATION. IN ADDITION TO LYME DISEASE, OTHER TICK-BORNE INFECTIONS ARE INCREASING RAPIDLY AND INCIDENCE OF MOSQUITO-BORNE ARBOVIRUSES INCLUDING EASTERN EQUINE ENCEPHALITIS VIRUS AND EMERGING JAMESTOWN CANYON VIRUS ARE A CONCERN. OUR ABILITY TO RESPOND TO THESE VECTOR-BORNE DISEASE THREATS IS LIMITED AND WE NEED NEW WAYS OF ADDRESSING AND PREVENTING THESE CHALLENGES. ONE ROOT CAUSE OF THE PROBLEM IS A LACK OF TRAINED PROFESSIONALS WHO CAN ADDRESS VECTOR-BORNE DISEASE THREATS. THERE IS ALSO A GROWING NEED TO EVALUATE THE EFFICACY OF VECTOR-BORNE DISEASE PREVENTION STRATEGIES THAT ARE GROUNDED IN COMMUNITY- AND REGIONAL-SPECIFIC CONTEXTS. IN THIS PROPOSAL, WE OUTLINE A TRAINING AND EVALUATION AGENDA THAT WILL ADDRESS THESE GAPS AND FILL CRITICAL NEEDS. THE HIGHLY INTEGRATIVE NORTHEAST REGIONAL CENTER FOR EXCELLENCE IN VECTOR-BORNE DISEASES (NEVBD) WILL ACCOMPLISH THESE GOALS ACROSS 3 SPECIFIC AIMS: (1) INCREASE OPPORTUNITIES FOR STUDENTS AND PROFESSIONALS TO RECEIVE TRAINING IN VECTOR-BORNE DISEASE PREVENTION AND CONTROL, (2) EVALUATE THE IMPACT AND EFFECTIVENESS OF VECTOR-BORNE DISEASE PREVENTION AND CONTROL PROGRAMS, TOOLS, AND STRATEGIES, AND (3) BUILD PARTNERSHIPS AMONG RELEVANT STAKEHOLDERS. OUR COLLABORATIVE EFFORTS WILL FOCUS ON IDENTIFYING THE PRESSING NEEDS FOR ACADEMIC, PROFESSIONAL, AND CLINICAL AUDIENCES REGARDING VECTOR-BORNE DISEASE KNOWLEDGE, TRAINING, AND WORKFORCE CAPACITY. WE WILL CONTINUE TO SUPPORT AND EXPAND TRAINING EFFORTS WITH A PROVEN TRACK RECORD OF SUCCESS, INCLUDING OUR INNOVATIVE DEGREE PROGRAMS AND HANDS-ON BOOT CAMPS AND WORKSHOPS ADDRESSING PROFESSIONAL DEVELOPMENT NEEDS IN THE NORTHEAST REGION. OUR EXPANDED ACADEMIC OPPORTUNITIES WILL INCLUDE SUPPORT FOR UNDERGRADUATE COURSEWORK, INTERNSHIPS, AND MASTER OF PUBLIC HEALTH APPLIED PRACTICAL EXPERIENCES IN VECTOR ECOLOGY, BIOLOGY, SURVEILLANCE, AND CONTROL. WE WILL ENHANCE OUR FOCUS ON DIVERSITY, EQUITY, AND INCLUSION THROUGH TARGETED RECRUITMENT AND ENGAGEMENT WITH UNDERREPRESENTED POPULATIONS IN THE STEM FIELD THROUGH THESE ACADEMIC TRAINING OPPORTUNITIES, INCLUDING A SPECIFIC FOCUS ON ENGAGEMENT WITH TRIBAL COMMUNITIES IN THE REGION. OUR PROFESSIONAL DEVELOPMENT OPPORTUNITIES WILL BE EXPANDED TO INCLUDE OPTIMIZATION OF CONTINUING MEDICAL EDUCATION OPPORTUNITIES FOR FRONTLINE MEDICAL PROVIDERS AND THE DEVELOPMENT OF A CERTIFICATE IN MEDICAL ENTOMOLOGY. OUR EFFORTS INCLUDE EVALUATION, STANDARDIZATION, AND IMPROVEMENT OF EXISTING VECTOR CONTROL TOOLS AND SURVEY TOOLS TO PROVIDE ROBUST ASSESSMENTS OF THE PERCEPTIONS AND BEHAVIORS OF COMMUNITIES AT INCREASED RISK OF VECTOR-BORNE DISEASE IN THE NORTHEAST REGION. WE HAVE ASSEMBLED AN INTERDISCIPLINARY NETWORK OF HIGHLY ACCOMPLISHED AND TALENTED EXPERTS REPRESENTING THE BROAD SPECTRUM OF ESSENTIAL SKILLS AND PERSPECTIVES NECESSARY TO CARRY OUT OUR PROPOSED GOALS IN TRAINING AND EVALUATION.
Department of Labor
$7M
PROGRAM PURPOSE AWARD THE PURPOSE OF THIS PROGRAM IS TO IDENTIFY AND PROMOTE ADOPTION OF INNOVATIVE AND EQUITABLEEVIDENCE-BASED POLICY AND PRACTICE SOLUTIONS TO HELP PUBLIC AND PRIVATE SECTOR EMPLOYERS OF ALLSIZES RECRUIT, HIRE, RETAIN, AND ADVANCE PEOPLE WITH DISABILITIES, INCLUDING THOSE FROM HISTORICALLYUNDERSERVED COMMUNITIES. THE RECIPIENT WILL CONDUCT RESEARCH THAT VALUES THE PERSPECTIVES OF HISTORICALLY UNDERSERVED GROUPS, CONDUCT POLICY ANALYSIS TO IDENTIFY AND VALIDATEEFFECTIVE DISABILITY-INCLUSIVE POLICY AND PRACTICE MODELS, TRANSLATE THAT KNOWLEDGE INTO ENGAGINGTOOLS FOR EMPLOYERS AND INTERMEDIARY ORGANIZATIONS, AND PROVIDE TECHNICAL ASSISTANCE AND TRAININGTO HELP EMPLOYERS OF ALL SIZES, BOTH PUBLIC AND PRIVATE, CREATE INCLUSIVE WORKPLACE CULTURES THATSUPPORT HIGH-QUALITY EMPLOYMENT OF PEOPLE WITH DISABILITIES. ACTIVITIES TO BE PERFORMED 1. IDENTIFY EMPLOYER NEEDS: ENGAGING WITH EMPLOYERS AND BUSINESS INTERMEDIARIES REGARDING THEIR EEDS, INCLUDING INTERMEDIARIES REPRESENTING PEOPLE WITH DISABILITIES AND HISTORICALLY UNDERSERVED COMMUNITIES 2. CONDUCT RESEARCH: CONDUCTING RESEARCH AND POLICY ANALYSIS TO IDENTIFY PRACTICES AND POLICY SOLUTIONS TO ADDRESS IDENTIFIED PROBLEMS. SEEK TO UNDERSTAND RELATED PERSPECTIVES, EXPERIENCES, AND OUTCOMES OF PEOPLE WITH DISABILITIES AND MULTIPLY MARGINALIZED IDENTITIES. 3. DEVELOP AND DISSEMINATE NEEDED RESOURCES: COLLABORATING WITH PARTNERS TO DEVELOP AND SHARE RESOURCES DELIVERABLES EXPECTED OUTCOME RESEARCH, POLICY, AND TOOL RESOURCE DEVELOPMENT THAT IS INFORMED BY PARTNERS STRENGTHENED RELATIONSHIPS AND INCREASED UNDERSTANDING OF DISABILITY INCLUSION AMONG PARTNERS. EFFECTIVE POLICY AND PRACTICE SOLUTIONS IDENTIFIED TO INFORM TOOLS AND RESOURCE DEVELOPMENT. EMPLOYERS AND COMMUNITY ORGANIZATIONS HAVE ACCESS TO EQUITABLE TOOLS RESOURCES RELEVANT TO THEIR NEEDS AND TAILORED TO SUPPORT IMPLEMENTATION OF SOLUTIONS INCREASED AWARENESS OF EARN AND ITS RESOURCES ADOPTION AND UTILIZATION OF EQUITABLE AND INNOVATIVE POLICIES, PRACTICES, AND TOOLS RESOURCES. THE INCLUSION AT WORKLEADERSHIP COUNCIL INTENDED BENEFICIARY(IES)HISTORICALLY UNDERSERVED GROUPS, DISABLED PERSONS, PUBLIC AND PRIVATE EMPLOYERS AND INTERMEDIARY ORGANIZATIONS . SUBRECIPIENT ACTIVITIES CONCEPTS, INC., THE COMMUNICATION PARTNER PLAYS A CRITICAL ROLE IN THE ACHIEVEMENT OF OUR TECHNICAL ASSISTANCE, OUTREACH AND DISSEMINATION EFFORTS AS THEY ARE RESPONSIBLE FOR OUTREACH TO NEW AUDIENCES, SUPPORTING EXISTING RELATIONSHIPS WITH PARTNERS, REVIEWING AND POLISHING OUR TOOLS AND RESOURCES, AND CONDUCTING SOCIAL MEDIA AND OTHER PROMOTIONAL ACTIVITIES FOR EARN CONTENT. RUTGERS, THE EXTERNAL EVALUATION PARTNER, WILL CONDUCT AND SHARE ONGOING FORMATIVE AND SUMMATIVE EVALUATION FOR CONTINUOUS IMPROVEMENT OF THE PROJECT. THEY WILL EVALUATE OUR ABILITY TO DEVELOP DELIVERABLES THAT MEET AGREED UPON PERFORMANCE INDICATORS, OUR ENGAGEMENT WITH OUR AUDIENCES, AND THE IMPACT THE PROJECT HAS ON EMPLOYER ORGANIZATIONS BECAUSE OF ADOPTION OF EARN WORK INTO POLICY AND PRACTICE.
National Science Foundation
$7M
THE GENETIC BASIS OF TRANSGRESSIVE VARIATION IN RICE
Department of Health and Human Services
$7M
SYSTEMIC REGULATION OF METASTASIS
Department of Defense
$6.9M
MULTIVARIATE HEAVY TAIL PHENOMENA: MODELING AND DIAGNOSTICS
Department of Health and Human Services
$6.9M
INTERNAL BONDING IN PROTEINS
Department of Health and Human Services
$6.9M
OPTIMIZING PAIN TREATMENT IN CHILDREN ON MECHANICAL VENTILATION (OPTICOM) - PROJECT SUMMARY/ABSTRACT MORE THAN 24,000 CHILDREN DEVELOP ACUTE RESPIRATORY FAILURE (ARF) AND REQUIRE INVASIVE MECHANICAL VENTILATION (MV) – AN INTRUSIVE, PAINFUL, YET LIFESAVING PROCEDURE – IN THE US EACH YEAR. THERE IS A CRITICAL KNOWLEDGE GAP REGARDING THE OPTIMAL APPROACH FOR ANALGOSEDATION (ANALGESIA-BASED SEDATION) IN THESE CHILDREN. AS A RESULT, THE CURRENT STANDARD-OF-CARE IS TO PROVIDE OPIOIDS FOR THE DURATION OF MV. DESPITE HIGH-DOSE OPIOID EXPOSURE, MORE THAN 90% OF THESE CHILDREN HAVE SUBOPTIMAL PAIN CONTROL. STUDIES SHOW THAT REPEATED EPISODES OF ACUTE PAIN AND PROLONGED OPIOID EXPOSURE PUT CHILDREN AT RISK FOR CHRONIC PAIN, OPIOID TOLERANCE, WITHDRAWAL, DELIRIUM, AND OTHER NEGATIVE EFFECTS. YET, FEW RANDOMIZED CONTROLLED TRIALS (RCTS) TARGET OPTIMIZING ACUTE PAIN MANAGEMENT IN THIS HIGH-RISK POPULATION. IN OUR STUDY, OPTIMIZING PAIN TREATMENT IN CHILDREN ON MECHANICAL VENTILATION (OPTICOM), THE CENTRAL HYPOTHESIS IS THAT A PROTOCOLIZED STRATEGY OF ADMINISTERING NON-OPIOID ADJUVANT THERAPIES TO CHILDREN WITH ARF WILL REDUCE PAIN AND DECREASE OPIOID EXPOSURE. THE PRIMARY OBJECTIVE OF OPTICOM IS TO DEFINE THE EFFECTIVENESS OF SUPPLEMENTING OPIOIDS WITH ACETAMINOPHEN AND/OR KETOROLAC AT DECREASING EPISODES OF ACUTE PAIN IN CHILDREN WITH ARF ON MV. THIS LARGE-SCALE MULTI-SITE DOUBLE- BLIND PLACEBO CONTROLLED RCT WILL ENROLL 644 CHILDREN ACROSS 14 PEDIATRIC INTENSIVE CARE UNITS (PICUS) AND RANDOMIZE TO ONE OF 4 ARMS: ACETAMINOPHEN + PLACEBO; KETOROLAC + PLACEBO; ACETAMINOPHEN + KETOROLAC; OR PLACEBO + PLACEBO. WE WILL SYSTEMATICALLY MONITOR ALL CHILDREN FOR ACUTE PAIN FOR THE FIRST 5 DAYS OF IMV AND QUANTIFY TOTAL OPIOID EXPOSURE IN MORPHINE MILLIGRAM EQUIVALENTS PER KG AS DEFINED BY THE HEAL COMMON DATA ELEMENTS. EFFECTS OF ACETAMINOPHEN AND KETOROLAC WILL BE DETERMINED USING A 2X2 FACTORIAL DESIGN. THIS INNOVATIVE PROPOSAL WILL LEVERAGE THE EXTENSIVE RESOURCES AND EXPERIENCE OF THE COLLABORATIVE PEDIATRIC CRITICAL CARE RESEARCH NETWORK (CPCCRN) AT EXECUTING CLINICAL TRIALS IN THE COMPLICATED PICU ENVIRONMENT TO ACHIEVE RESULTS WITHIN THE 5-YEAR STUDY PERIOD. CPCCRN WILL ENSURE ENROLLMENT OF A GEOGRAPHICALLY, RACIALLY, AND SOCIOECONOMICALLY DIVERSE PATIENT POPULATION TO ALLOW FOR WIDE GENERALIZABILITY OF STUDY FINDINGS. BY EXPANDING HEAL-KIDS RESEARCH INTO A UNIQUE AND UNSTUDIED POPULATION, THIS PROJECT WILL LEAD TO A PARADIGM SHIFT IN THE CARE PROVIDED TO CRITICALLY ILL CHILDREN. CONSISTENT WITH THE GOALS OF THE ACUTE PAIN CLINICAL TRIALS PROGRAM, THE OPTICOM STUDY WILL ADVANCE THE TREATMENT OF ACUTE PAIN IN A DIVERSE POPULATION OF CHILDREN ACROSS THE AGE- SPECTRUM AND ADVANCE OUR ULTIMATE GOAL OF DEVELOPING COMPREHENSIVE EVIDENCE-BASED CLINICAL GUIDELINES FOR MANAGEMENT OF PAIN IN CHILDREN WITH ARF.
Department of Health and Human Services
$6.9M
CENTRAL THALAMIC STIMULATION FOR TRAUMATIC BRAIN INJURY
Department of Health and Human Services
$6.8M
MAMMALIAN DNA REPAIR PROTEINS IN MEIOTIC RECOMBINATION
Department of Health and Human Services
$6.8M
COORDINATE GENE REGULATION IN ANIMAL CELLS
Environmental Protection Agency
$6.7M
THIS PROJECT SUPPORTS THE GREAT LAKES RESTORATION INITIATIVE (GLRI) AND THE GREAT LAKES WATER QUALITY AGREEMENT, PURSUANT TO CLEAN WATER ACT, SECTION 118(C)(7), AS AMENDED BY PUBLIC LAW 114-322, TO PROTECT AND RESTORE THE CHEMICAL, PHYSICAL AND BIOLOGICAL INTEGRITY OF THE GREAT LAKES BASIN ECOSYSTEM. THE GREAT LAKES BIOLOGY MONITORING PROGRAM (GLBMP): ZOOPLANKTON, MYSIS, AND BENTHOS COMPONENTS BENEFITS FEDERAL, STATE, AND TRIBAL FISHERIES AND WATER QUALITY MANAGERS BY FOCUSING ON WHOLE-LAKE RESPONSES TO CHANGES IN LOADS OF ANTHROPOGENIC SUBSTANCES, AND MORE RECENTLY, AQUATIC INVASIVE SPECIES. SPECIFICALLY, THIS PROJECT WILL ASSESS AND INVESTIGATE THE ECOLOGICAL HEALTH OF THE GREAT LAKES BY SAMPLING AND ANALYZING THE COMMUNITY STRUCTURE OF THE BIOTA.
Department of Health and Human Services
$6.7M
CENTRAL PROCESSING OF VISUAL INFORMATION
Department of Health and Human Services
$6.7M
NEW TARGETS FOR REPRODUCTIVE CONTROL OF MOSQUITO VECTORS
Department of Health and Human Services
$6.7M
MACROPHAGE-LIPOPROTEIN INTERACTIONS
Department of Education
$6.6M
NATIONAL INSTITUTE ON DISABILITY AND REHABILITATION RESEARCH - DISABILITY AND REHABILITATION RESEARCH PROJECTS
Department of Health and Human Services
$6.6M
WEILL CORNELL/ROCKEFELLER/SLOAN KETTERING MST PROGRAM - PROJECT SUMMARY THE MISSION OF THE TRI-INSTITUTIONAL MD-PHD PROGRAM (TRI-I) IS TO TRAIN A DIVERSE AND EMPOWERED GROUP OF CLINICIAN-SCIENTISTS PREPARED TO BRIDGE THE GAP BETWEEN LABORATORY RESEARCH AND CLINICAL MEDICINE. GRADUATES OF THE PROGRAM ARE WELL-GROUNDED IN HUMAN BIOLOGY, PATHOPHYSIOLOGY, AND CLINICAL MEDICINE AND ARE ENDOWED WITH AN ADVANCED UNDERSTANDING OF BIOMEDICAL SCIENCE, AS WELL AS A MASTERY OF CRITICAL THINKING AND EXPERIMENTAL SKILLS. THESE SKILLS WILL ALLOW THEM TO UNDERTAKE COMPLEX, INTERDISCIPLINARY, QUANTITATIVE, AND COLLABORATIVE STUDIES TO ELUCIDATE BASIC BIOLOGICAL PROCESSES PERTAINING TO HUMAN HEALTH AND DISEASE AND TO TRANSFER ADVANCES IN RESEARCH TO THE UNDERSTANDING, PREVENTION, AND TREATMENT OF HUMAN DISEASE. TRI-I IS A JOINT UNDERTAKING BETWEEN WEILL CORNELL MEDICINE (WCM), THE ROCKEFELLER UNIVERSITY (RU), AND MEMORIAL SLOAN KETTERING CANCER CENTER (MSK). TRAINEES COMPLETE THEIR MD DEGREE AT WEILL CORNELL MEDICAL COLLEGE (WCMC), AND PHD TRAINING AT ONE OF THE THREE PARTICIPATING GRADUATE SCHOOLS: WEILL CORNELL GRADUATE SCHOOL OF MEDICAL SCIENCES (WCGS); THE DAVID ROCKEFELLER GRADUATE PROGRAM IN BIOSCIENCE AT RU; OR THE LOUIS V. GERSTNER JR. GRADUATE SCHOOL OF BIOMEDICAL SCIENCES (GSK) AT MSK. AN INTEGRATED CURRICULUM REINFORCES THE STUDENTS’ IDENTITIES AS CLINICIAN- SCIENTISTS. IN THE FIRST TWO YEARS IN THE PROGRAM, MD-PHD-SPECIFIC GRADUATE-LEVEL COURSEWORK, INCLUDING TRAINING IN QUANTITATIVE METHODS, RESPONSIBLE CONDUCT OF RESEARCH, AND RIGOR AND REPRODUCIBILITY, IS INTEGRATED WITH PRE- CLINICAL MEDICAL SCHOOL COURSES AND 18 WEEKS OF CORE CLINICAL CLERKSHIPS. STUDENTS COMPLETE THREE LABORATORY RESEARCH ROTATIONS IN AT LEAST TWO DIFFERENT INSTITUTIONS BEFORE SELECTING A THESIS LAB AND ENROLLING IN THE GRADUATE SCHOOL AT WHICH THEIR THESIS MENTOR HAS THEIR PRIMARY APPOINTMENT. PHD REQUIREMENTS ARE COMPARABLE FOR ALL MD- PHD STUDENTS ACROSS GRADUATE INSTITUTIONS, AND TRAINEES MAY TAKE COURSES FOR CREDIT IN ANY OF THE GRADUATE SCHOOLS. AFTER THEY HAVE DEFENDED THEIR THESIS, TRAINEES COMPLETE THEIR REMAINING CLINICAL TRAINING AT WCMC. OVER 200 PARTICIPATING FACULTY MEMBERS SERVE AS MENTORS AND UNDERGO TRAINING TO ENSURE A SAFE TRAINING ENVIRONMENT, RESPONSIBLE CONDUCT OF RESEARCH, AND SCIENTIFIC RIGOR AND REPRODUCIBILITY. STUDENTS RECEIVE MULTI-LAYERED MENTORSHIP AND ADVISING, PARTICULARLY AROUND TRANSITIONS TO AND FROM THE LABORATORY AND IN PREPARATION FOR POST- GRADUATE RESIDENCY TRAINING. BASED ON TRI-I’S HIGH TRAINEE RETENTION IN THE PROGRAM AND IN ACADEMIA AND BIOMEDICAL RESEARCH FOLLOWING GRADUATION, THIS APPLICATION REQUESTS FUNDS TO SUPPORT 49 TRAINEES PER YEAR. NO TRAINEE WILL BE APPOINTED TO THE GRANT FOR MORE THAN A TOTAL OF FOUR YEARS. THE STUDENT BODY AVERAGES 150 MD- PHD TRAINEES; CURRENTLY, 47% IDENTIFY AS WOMEN AND 23% COME FROM RACIAL AND ETHNIC BACKGROUNDS UNDERREPRESENTED IN MEDICINE AND SCIENCE. OVER THE PAST 50 YEARS, 451 MD-PHDS HAVE GRADUATED FROM TRI-I AND ITS PREDECESSORS. IN THE PAST 15 YEARS, 85% OF GRADUATES HAVE APPOINTMENTS IN MEDICAL SCHOOLS, RESEARCH INSTITUTES, OR BIOTECH/PHARMA. TRI-I IS COMMITTED TO MAINTAINING ITS LONGSTANDING TRADITION OF TRAINING FUTURE LEADERS OF BIOMEDICAL RESEARCH.
Department of Health and Human Services
$6.6M
MITOCHONDRIAL INTEGRATED STRESS RESPONSE IN NEUROLOGICAL DISEASES - MITOCHONDRIA PLAY ESSENTIAL ROLES IN CELL BIOLOGY BECAUSE ARE CENTRAL HUBS OF MOST METABOLIC PATHWAYS. THEY ARE NOT ONLY ESSENTIAL FOR ENERGY CONVERSION, BUT ALSO FOR THE BIOSYNTHESIS AND CATABOLISM OF VIRTUALLY ALL CELL CONSTITUENTS. MITOCHONDRIAL DYSFUNCTION CAUSES HAVOC IN ALL CELLS, BUT ESPECIALLY IN THOSE CELL TYPES THAT ARE HIGHLY DEPENDENT ON MITOCHONDRIAL ENERGETIC AND METABOLIC FUNCTIONS, SUCH AS NEURONS AND GLIA. GENETIC ALTERATIONS OF THE MITOCHONDRIAL PROTEOME, WHICH INCLUDES MORE THAN 1000 PROTEINS, ENCODED BY BOTH THE NUCLEAR AND THE MITOCHONDRIAL GENOMES, RESULT IN PRIMARY MITOCHONDRIAL DISORDERS. THESE DISEASES, FOR WHICH THERE IS CURRENTLY NO EFFECTIVE TREATMENT, RESULT IN SEVERE AND OFTEN FATAL NEURODEGENERATION. MITOCHONDRIAL DYSFUNCTION ALSO PLAYS A ROLE IN THE PATHOGENESIS OF MANY AGE-RELATED NEURODEGENERATIVE DISORDERS, SUCH AS ALZHEIMER AND PARKINSON DISEASE AND ALS. THEREFORE, ADDRESSING THERAPEUTICALLY THE CONSEQUENCES OF MITOCHONDRIAL DYSFUNCTION COULD HAVE A PROFOUND IMPACT ON THE TREATMENT OF MANY HUMAN DISORDERS. A MAJOR CHALLENGE IN DEVISING EFFECTIVE TREATMENTS FOR MITOCHONDRIAL ENCEPHALOPATHIES IS OUR LIMITED UNDERSTANDING OF THE RAMIFICATIONS OF THE EFFECTS OF MITOCHONDRIAL DYSFUNCTION. THE CONVENTIONAL VIEW THAT THESE DISORDERS ARE CAUSED SIMPLY BY ENERGY FAILURE IS INADEQUATE, AS IT IS BECOMING INCREASINGLY CLEAR THAT MITOCHONDRIAL DYSFUNCTION AFFECTS MUCH MORE THAN JUST ATP GENERATION AND LEADS TO AN EXTENSIVE REWIRING OF CELL METABOLISM. AN EXCITING NEW DEVELOPMENT IN THE FIELD IS THE OBSERVATION THAT VARIOUS TYPES OF MITOCHONDRIAL DYSFUNCTION ACTIVATE TRANSCRIPTIONAL AND METABOLIC RESPONSES THAT INVOLVE MULTIPLE STRESS SIGNALING PATHWAYS. WE AND OTHERS HAVE IDENTIFIED A “MITOCHONDRIAL INTEGRATED STRESS RESPONSE” (MTISR) IN DIVERSE GENETIC FORMS OF MITOCHONDRIAL DISORDERS, SUGGESTING THAT MTISR IS STRONGLY ASSOCIATED WITH MITOCHONDRIAL DISEASES AND A POTENTIAL PATHOGENIC COMMON DENOMINATOR. WE POSTULATE THAT, WHILE IN THE SHORT TERM THESE RESPONSES MAY BE COMPENSATORY, IF SUSTAINED AND UNRESOLVED, THEY BECOME MALADAPTIVE AND CAUSES IMBALANCES OF KEY METABOLITES, WHICH MAY BE MORE DETRIMENTAL THAN THE ENERGY DEFECT ITSELF. WHILE WE NOW FULLY APPRECIATE THESE MALADAPTIVE MECHANISMS IN PERIPHERAL TISSUES, SUCH AS MUSCLE AND HEART, VERY LITTLE IS KNOWN ABOUT THEM IN THE CNS AFFECTED BY MITOCHONDRIAL ENCEPHALOPATHIES. A DEEPER KNOWLEDGE OF THE CHARACTERISTICS AND THE CONSEQUENCES OF THE MTISR IN THE CNS IS NEEDED TO UNDERSTAND ITS PATHOGENIC SIGNIFICANCE AND DEVELOP TARGETS THERAPEUTIC STRATEGIES. OUR RESEARCH GROUP HAS A LONG-STANDING COMMITMENT TO INVESTIGATING THE PATHOGENIC MECHANISMS OF MITOCHONDRIAL DISEASES AND WE HAVE ACCUMULATED OVER TWO DECADES OF EXPERTISE IN STUDYING THE MECHANISMS OF MITOCHONDRIAL ENCEPHALOPATHIES AND MITOCHONDRIAL DYSFUNCTION IN NEURODEGENERATION. IN THIS R35 APPLICATION, WE FOCUS ON FUNDAMENTAL GAPS IN KNOWLEDGE ON THE MTISR IN MITOCHONDRIAL ENCEPHALOPATHIES BY STUDYING DISEASE MODELS THAT RECAPITULATE HUMAN DISEASES. WE WILL USE A SERIES OF APPROACHES, BOTH ESTABLISHED AND TECHNOLOGICALLY INNOVATIVE, TO GENERATE A BLUEPRINT OF THE METABOLIC REWIRING IN THE DISEASED CNS AND IDENTIFY TARGETS POTENTIALLY RESPONSIVE TO THERAPEUTIC MODULATION.
Department of Health and Human Services
$6.6M
BLOOD PRESSURE, CEREBRAL PERFUSION & COGNITIVE OUTCOME IN HYPERTENSION.
Department of Defense
$6.6M
THERAPEUTIC TARGETING OF BREAST CANCER AND HOST IMMUNE RESPONSES AT INFLECTION POINTS IN THE DISEASE TRAJECTORY
Department of Agriculture
$6.6M
RECENT ANALYSES HAVE EMPHASIZED THE ECONOMIC AND ENVIRONMENTAL IMPORTANCE OF DEVELOPING NEW GRAPE CULTIVARS WITH HIGH FRUIT QUALITY (FQ) AND RESISTANCE TO POWDERY MILDEW (PM). AN ADVISORY PANEL OF TABLE, JUICE, RAISIN AND WINE GRAPE INDUSTRY MEMBERS CONCURS THAT HIGH-QUALITY, PM-RESISTANT CULTIVARS ARE A TOP PRIORITY. THE PROPOSED PROJECT (VITISGEN2) WILL I) EXPAND ON VITISGEN PROGRESS IN DEVELOPING NOVEL ECONOMIC, PHENOTYPING AND GENETICS KNOWLEDGE AND TOOLS RELATED TO NEW GRAPE CULTIVARS, AND II) TRANSLATE THESE AND PREVIOUS VITISGEN INNOVATIONS INTO NEW APPLICATIONS FOR IMPROVING GRAPE BREEDING PROGRAMS AND MANAGING EXISTING VINEYARD PLANTINGS. THE ECONOMICS TEAM WILL EVALUATE THE CONSEQUENCES OF INTRODUCING NEW GRAPE TRAITS, INCLUDING IMPACTS UPON COST, YIELD, REVENUE, PROFIT, PESTICIDE USE, AND THE ENVIRONMENT. THE TRAIT EVALUATION TEAM WILL DEVELOP NOVEL HIGH-THROUGHPUT METHODS, AND APPLY THESE ALONG WITH PROVEN APPROACHES TO CHARACTERIZE A RANGE OF PHENOTYPES, SUCH AS PM RESISTANCE DURABILITY AND UNDESIRABLE FRUIT QUALITIES, AS WELL AS LOCALLY IMPORTANT TRAITS. THE GENETICS TEAM WILL COUPLE PHENOTYPING RESULTS WITH HIGH-RESOLUTION GENETIC MAPS, WHICH CAN BE COMBINED WITH GENOME ASSEMBLY AND RNA-SEQ ANALYSES TO DEVELOP INEXPENSIVE, HIGH-RESOLUTION MARKERS SPANNING KEY GENES. FINALLY, THE OUTREACH TEAM WILL COMMUNICATE SCIENTIFIC OPPORTUNITIES AND DISCOVERIES, AND PROVIDE STAKEHOLDERS WITH KNOWLEDGE OF THE BENEFITS OF ADOPTING NEW HIGH-QUALITY PM-RESISTANT CULTIVARS ALONG WITH NEW TOOLS FOR CHARACTERIZING PM AND FQ IN THEIR EXISTING PLANTINGS. THE PROPOSED WORK UTILIZES PLANT BREEDING AND GENOMICS APPROACHES TO IMPROVE GRAPE CHARACTERISTICS AND ENHANCE THE ECONOMIC AND ENVIRONMENTAL SUSTAINABILITY OF GRAPE PRODUCTION.
Department of Health and Human Services
$6.6M
HEAL DATA2ACTION MODELING AND ECONOMIC RESOURCE CENTER - THE HEAL DATA2ACTION (D2A) PROGRAM IS A COORDINATED EFFORT TO PROMOTE THE SYNTHESIS AND REAL-WORLD APPLICATION OF EXISTING DATA TO GUIDE AND MONITOR IMPROVEMENTS IN SERVICE DELIVERY TO PREVENT OR TREAT OPIOID USE DISORDER (OUD) AND PAIN. COLLECTIVELY, THESE PROJECTS WILL ADDRESS GAPS IN THE DELIVERY OF EVIDENCE-BASED PRACTICES IN EACH OF THE FOUR PILLARS OF THE HHS OVERDOSE PREVENTION STRATEGY: PRIMARY PREVENTION, HARM REDUCTION, TREATMENT OF OPIOID USE DISORDER, AND RECOVERY SUPPORT. THE HEAL D2A MODELING AND ECONOMIC RESOURCE CENTER (MERC) WILL SUPPORT THE HEAL D2A INNOVATION PROJECTS BY PROVIDING EXPERTISE IN SIMULATION MODELING AND ECONOMIC EVALUATION METHODS AND WILL CONSULT WITH THE HEAL D2A INNOVATION GRANT RECIPIENTS ON APPLYING THESE METHODS AND INSIGHTS IN THEIR LOCAL IMPLEMENTATION ACTIVITIES. THE MERC WILL ALSO CONDUCT ORIGINAL RESEARCH APPLYING STATE-OF-THE-ART ECONOMIC AND SIMULATION MODELING EXPERTISE TO UNDERSTAND AND ADDRESS THE OVERDOSE CRISIS. SINCE 2015, WE HAVE WORKED COLLABORATIVELY TO LEAD A HIGHLY SUCCESSFUL MULTI- INSTITUTIONAL NIDA-FUNDED NATIONAL CENTER OF EXCELLENCE, THE CENTER FOR HEALTH ECONOMICS OF TREATMENT INTERVENTIONS FOR SUBSTANCE USE DISORDER, HCV, AND HIV (CHERISH). WE ARE THUS UNIQUELY QUALIFIED TO LEAD THE HEAL D2A MERC WITH THE FOLLOWING AIMS: 1) TO SUPPORT THE HEAL D2A INNOVATION PROJECTS BY PROVIDING METHODOLOGICAL CONSULTATION ON THE APPLICATION OF RIGOROUS MODELING TECHNIQUES, COST ANALYSES, AND BEHAVIORAL ECONOMIC STRATEGIES TO SUPPORT THE PROJECTS' SELECTION AND IMPLEMENTATION OF EVIDENCE-BASED PRACTICES TO ADDRESS SERVICE DELIVERY NEEDS; 2) TO DEVELOP TOOLS THAT CAN BE READILY USED BY THE INNOVATION PROJECTS TO MAKE INFORMED DECISIONS ABOUT THE RELATIVE COSTS OF DIFFERENT IMPLEMENTATION INTERVENTIONS TO DIFFERENT STAKEHOLDERS, TO MEASURE THE OVERALL COSTS OF THESE EFFORTS, AND TO INFORM THE DESIGN OF APPROPRIATE PAYMENT SYSTEMS THAT SUPPORT SUSTAINABILITY; 3) TO USE META-MODELING TECHNIQUES TO DEVELOP A USER-FRIENDLY INTERFACE SO THAT SIMULATION MODEL RESULTS GENERATED FOR ONE SYSTEM OR COMMUNITY CAN BE ADAPTED FOR OTHER SYSTEMS/COMMUNITIES OR ADAPTED WHEN LOCAL CIRCUMSTANCES CHANGE; 4) TO CONDUCT NOVEL RESEARCH USING ADVANCED MODELING AND HEALTH ECONOMICS APPROACHES THAT BUILD ON EXISTING DATA TO PROVIDE INSIGHTS INTO THE COMPLEX DYNAMICS OF ADDRESSING THE OVERDOSE CRISIS THROUGH STRATEGIC IMPLEMENTATION OF EVIDENCE-BASED PRACTICES. THE HEAL D2A MERC WILL SUPPORT THE APPLICATION OF HEALTH ECONOMICS AND MODELING RESEARCH TO REAL-WORLD DECISION MAKING ABOUT SERVICES TO PREVENT OR TREAT OPIOID USE DISORDER AND PAIN, WILL FURTHER SCIENTIFIC INNOVATION IN THE FIELD, AND WILL ESTABLISH A PARADIGM FOR INTEGRATING HEALTH ECONOMICS AND MODELING INTO SUBSTANCE USE TREATMENT AND PREVENTION POLICIES AT THE SYSTEM LEVEL. THE HEAL D2A MERC WILL BE COLLABORATIVE WITH THE WORK OF THE HEAL D2A RESEARCH ADOPTION SUPPORT CENTER (RASC), INCLUDING THE CONSULTATIONS AND CATALOG OF MEASURES AND TOOLS OF THE IMPLEMENTATION SUPPORT CORES, AND WILL LEVERAGE AND CONTRIBUTE TO THE RESOURCES OF THE HEAL D2A DATA INFRASTRUCTURE SUPPORT CENTER (DISC).
Department of Health and Human Services
$6.5M
CREATING NATIONAL SURVEILLANCE INFRASTRUCTURE FOR PRIORITY MEDICAL DEVICES
Department of Defense
$6.5M
PRECLINICAL READINESS OF PEDIATRIC HEART ASSIST SYSTEM FOR CONGENITAL HEART FAILURE IN INFANTS AND CHILDREN
Department of Health and Human Services
$6.5M
SCALE: SMALL CHANGES AND LASTING EFFECTS
Department of Health and Human Services
$6.4M
CONDITIONAL EXPRESSION OF MYCOBACTERIAL GENES
Source: Federal Audit Clearinghouse (fac.gov)
Total Audits
10
Clean Audits
10
Material Weakness
No
Noncompliance Issues
No
| Year | Status | Financial Report | Federal Expenditure | Low Risk | Accepted |
|---|---|---|---|---|---|
| 2025 | Clean | Unmodified (Clean) | $1B | Yes | 2026-03-25 |
| 2024 | Clean | Unmodified (Clean) | $985.6M | Yes | 2025-03-28 |
| 2023 | Clean | Unmodified (Clean) | $956.1M | Yes | 2024-03-28 |
| 2022 | Clean | Unmodified (Clean) | $892.5M | Yes | 2023-03-29 |
| 2021 | Clean | Unmodified (Clean) | $796.3M | Yes | 2022-08-24 |
| 2020 | Clean | Unmodified (Clean) | $754.1M | Yes | 2021-07-13 |
| 2019 | Clean | Unmodified (Clean) | $729M | Yes | 2020-02-12 |
| 2018 | Clean | Unmodified (Clean) | $679M | Yes | 2019-03-19 |
| 2017 | Clean | Unmodified (Clean) | $651.5M | Yes | 2018-02-28 |
| 2016 | Clean | Unmodified (Clean) | $642.3M | Yes | 2017-02-15 |
Financial Report
Unmodified (Clean)
Federal Expenditure
$1B
Financial Report
Unmodified (Clean)
Federal Expenditure
$985.6M
Financial Report
Unmodified (Clean)
Federal Expenditure
$956.1M
Financial Report
Unmodified (Clean)
Federal Expenditure
$892.5M
Financial Report
Unmodified (Clean)
Federal Expenditure
$796.3M
Financial Report
Unmodified (Clean)
Federal Expenditure
$754.1M
Financial Report
Unmodified (Clean)
Federal Expenditure
$729M
Financial Report
Unmodified (Clean)
Federal Expenditure
$679M
Financial Report
Unmodified (Clean)
Federal Expenditure
$651.5M
Financial Report
Unmodified (Clean)
Federal Expenditure
$642.3M
Tax Year 2023 · Source: IRS e-Filed Form 990Schedule J available
Individuals serving as officers, directors, or trustees of the organization.
| Name | Title | Hrs/Wk | Compensation | Related Orgs | Other |
|---|
Source: IRS Publication 78, Auto-Revocation List & e-Postcard Data
Tax-deductible contributions: Yes
Deductibility code: PC
990-N (e-Postcard) Filing History
This organization files simplified Form 990-N (annual gross receipts ≤ $50,000).
Sources: IRS e-Filed Form 990 (XML) & ProPublica Nonprofit Explorer
Scroll →
| Year | Revenue | Contributions | Expenses | Assets | Net Assets |
|---|---|---|---|---|---|
| 2023IRS e-File | $6.6B | $621.6M | $6.4B | $18.6B | $13.8B |
| 2022IRS e-File | $5.9B | $617.7M | $5.8B | $17.3B | $13.3B |
| 2021 | $6.1B | $660.3M | $5.4B | $17.4B | $13B |
| 2020 | $5.1B |
Sources: ProPublica Nonprofit Explorer & IRS e-File Index
| Tax Year | Form Type | Source | Documents |
|---|---|---|---|
| 2024 | 990 | IRS e-File | |
| 2023 | 990 | DataIRS e-File | PDF not yet published by IRSView Filing → |
| 2022 | 990 | DataIRS e-File |
Financial data: IRS e-Filed Form 990 (Tax Year 2023)
Leadership & compensation: IRS e-Filed Form 990, Part VII (Tax Year 2023)
Federal grants: USAspending.gov (live)
Organization info: IRS Business Master File
Tax-deductibility: IRS Publication 78
| Total |
|---|
| Martha E Pollack | President | 55 | $1.7M | $0 | $51.9K | $1.7M |
| Francis Lee | Interim Dean Of Wcm (1/1/23 - 9/11/23) | 55 | $1.3M | $0 | $69.5K | $1.4M |
| Robert Harrington | Provost For Medical Affairs & Dean | 55 | $1.1M | $0 | $5,747 | $1.1M |
| Michael I Kotlikoff | Provost | 55 | $910K | $0 | $103.9K | $1M |
| Donica Varner | University Counsel | 55 | $746.7K | $0 | $50.1K | $796.8K |
| Christopher J Cowen | EVP & CFO | 55 | $754.2K | $0 | $39.8K | $794K |
Martha E Pollack
President
$1.7M
Hrs/Wk
55
Compensation
$1.7M
Related Orgs
$0
Other
$51.9K
Francis Lee
Interim Dean Of Wcm (1/1/23 - 9/11/23)
$1.4M
Hrs/Wk
55
Compensation
$1.3M
Related Orgs
$0
Other
$69.5K
Robert Harrington
Provost For Medical Affairs & Dean
$1.1M
Hrs/Wk
55
Compensation
$1.1M
Related Orgs
$0
Other
$5,747
Michael I Kotlikoff
Provost
$1M
Hrs/Wk
55
Compensation
$910K
Related Orgs
$0
Other
$103.9K
Donica Varner
University Counsel
$796.8K
Hrs/Wk
55
Compensation
$746.7K
Related Orgs
$0
Other
$50.1K
Christopher J Cowen
EVP & CFO
$794K
Hrs/Wk
55
Compensation
$754.2K
Related Orgs
$0
Other
$39.8K
Highest compensated employees who are not officers or directors.
| Name | Title | Hrs/Wk | Compensation | Related Orgs | Other | Total |
|---|---|---|---|---|---|---|
| Zev Rosenwaks Md | Academic Professor | 55 | $9.3M | $0 | $58.8K | $9.4M |
| Kiehyun Daniel Riew Md | Assistant Professor | 55 | $6.1M | $0 | $68K | $6.2M |
| Leonard Girardi Md | Academic Chair | 55 | $5.9M | $0 |
Zev Rosenwaks Md
Academic Professor
$9.4M
Hrs/Wk
55
Compensation
$9.3M
Related Orgs
$0
Other
$58.8K
Kiehyun Daniel Riew Md
Assistant Professor
$6.2M
Hrs/Wk
55
Compensation
$6.1M
Related Orgs
$0
Other
$68K
Leonard Girardi Md
Academic Chair
$6M
Hrs/Wk
55
Compensation
$5.9M
Related Orgs
$0
Other
$46.5K
Members of the governing board. Board members often serve without compensation.
| Name | Title | Hrs/Wk | Compensation | Related Orgs | Other | Total |
|---|---|---|---|---|---|---|
| A'Ndrea L Van Schoick | Trustee | 2 | $0 | $0 | $0 | $0 |
| Abigail C Cohn | Professor & Trustee | 2 | $143.7K | $0 | $39.4K | $183K |
| Alexander D Hanson | Trustee | 2 | $0 | $0 | $0 | $0 |
| Ana G Pinczuk | Trustee | 2 | $0 | $0 | $0 | $0 |
| Andrea Stewart-Cousins | Trustee | 2 |
A'Ndrea L Van Schoick
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Abigail C Cohn
Professor & Trustee
$183K
Hrs/Wk
2
Compensation
$143.7K
Related Orgs
$0
Other
$39.4K
Alexander D Hanson
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Individuals who previously served as officers or key employees.
| Name | Title | Hrs/Wk | Compensation | Related Orgs | Other | Total |
|---|---|---|---|---|---|---|
| Augustine Mk Choi Md | Former Provost - Medical Affairs & Dean | 55 | $2M | $0 | $46.1K | $2M |
| Joanne M Destefano | Former CFO & EVP | 55 | $530K | $0 | $55.5K | $585.5K |
Augustine Mk Choi Md
Former Provost - Medical Affairs & Dean
$2M
Hrs/Wk
55
Compensation
$2M
Related Orgs
$0
Other
$46.1K
Joanne M Destefano
Former CFO & EVP
$585.5K
Hrs/Wk
55
Compensation
$530K
Related Orgs
$0
Other
$55.5K
| $511M |
| $5.2B |
| $14.4B |
| $10B |
| 2019 | $5B | $420.7M | $4.9B | $13.6B | $10.4B |
| 2018 | $5B | $437.6M | $4.6B | $13.3B | $10.3B |
| 2017 | $4.7B | $606M | $4.4B | $12.8B | $9.8B |
| 2016 | $4.4B | $510.4M | $4.2B | $12.4B | $8.9B |
| 2015 | $4.4B | $584.5M | $4B | $12.7B | $9.4B |
| 2014 | $4.4B | $842.6M | $3.7B | $12.5B | $9.2B |
| 2013 | $3.4B | $478.6M | $3.2B | $11.5B | $8.1B |
| 2012 | $3.4B | $672.3M | $3.1B | $10.9B | $7.5B |
| 2021 | 990 | Data | PDF not yet published by IRS |
| 2020 | 990 | Data |
| 2019 | 990 | Data |
| 2018 | 990 | Data |
| 2017 | 990 | Data |
| 2016 | 990 | Data |
| 2015 | 990 | Data |
| 2014 | 990 | Data |
| 2013 | 990 | Data |
| 2012 | 990 | Data |
| 2011 | 990 | — |
| 2010 | 990 | — |
| 2009 | 990 | — |
| 2008 | 990 | — |
| 2007 | 990 | — |
| 2006 | 990 | — |
| 2005 | 990 | — |
| 2004 | 990 | — |
| 2003 | 990 | — |
| 2002 | 990 | — |
| 2001 | 990 | — |
| $46.5K |
| $6M |
| Hey-Joo Kang Md | Associate Professor - Clinical | 55 | $5.4M | $0 | $58.3K | $5.4M |
| Rony T Elias Md | Assistant Professor | 55 | $4.6M | $0 | $58.8K | $4.7M |
| Robert J Min Md | Pres. & CEO Of Physician Org | 55 | $2.8M | $0 | $45.9K | $2.8M |
| Kenneth Miranda | Chief Invesment Officer | 55 | $2.8M | $0 | $34.5K | $2.8M |
| Scott Puccino | CFO & Assoc. Treasurer - Weill | 55 | $1.1M | $0 | $46.1K | $1.2M |
| Thomas Stokes | VP For Finance/cfo Wcm | 55 | $861.2K | $0 | $69K | $930.2K |
Hey-Joo Kang Md
Associate Professor - Clinical
$5.4M
Hrs/Wk
55
Compensation
$5.4M
Related Orgs
$0
Other
$58.3K
Rony T Elias Md
Assistant Professor
$4.7M
Hrs/Wk
55
Compensation
$4.6M
Related Orgs
$0
Other
$58.8K
Robert J Min Md
Pres. & CEO Of Physician Org
$2.8M
Hrs/Wk
55
Compensation
$2.8M
Related Orgs
$0
Other
$45.9K
Kenneth Miranda
Chief Invesment Officer
$2.8M
Hrs/Wk
55
Compensation
$2.8M
Related Orgs
$0
Other
$34.5K
Scott Puccino
CFO & Assoc. Treasurer - Weill
$1.2M
Hrs/Wk
55
Compensation
$1.1M
Related Orgs
$0
Other
$46.1K
Thomas Stokes
VP For Finance/cfo Wcm
$930.2K
Hrs/Wk
55
Compensation
$861.2K
Related Orgs
$0
Other
$69K
| $0 |
| $0 |
| $0 |
| $0 |
| Anne Meinig Smalling | Trustee | 2 | $0 | $0 | $0 | $0 |
| Aryan Shayegani Md | Trustee | 2 | $0 | $0 | $0 | $0 |
| Beth Anderson | Trustee | 2 | $0 | $0 | $0 | $0 |
| Bradley H Stone | Trustee | 2 | $0 | $0 | $0 | $0 |
| Bruce S Raynor | Trustee | 2 | $0 | $0 | $0 | $0 |
| Carl E Heastie | Trustee | 2 | $0 | $0 | $0 | $0 |
| Dale S Rosenthal | Trustee | 2 | $0 | $0 | $0 | $0 |
| Dan Bromberg | Graduate Student & Trustee | 2 | $31.2K | $0 | $0 | $31.2K |
| David J Breazzano | Trustee | 2 | $0 | $0 | $0 | $0 |
| David R Lee | Professor & Trustee | 2 | $1,207 | $0 | $1,207 | $2,414 |
| Deborah J Arrindell | Trustee | 2 | $0 | $0 | $0 | $0 |
| Doug Mitarotonda | Trustee | 2 | $0 | $0 | $0 | $0 |
| Eldora Ellison | Trustee | 2 | $0 | $0 | $0 | $0 |
| Enrique J Vila-Biaggi | Trustee | 2 | $0 | $0 | $0 | $0 |
| Eric Kutcher | Trustee | 2 | $0 | $0 | $0 | $0 |
| Ezra Cornell | Trustee | 2 | $0 | $0 | $0 | $0 |
| Gary S Davis | Co-vice Chairman | 2 | $0 | $0 | $0 | $0 |
| Gilda Perez-Alvarado | Trustee | 2 | $0 | $0 | $0 | $0 |
| Girish V Reddy | Trustee | 0.2 | $0 | $0 | $0 | $0 |
| Harriet P Schleifer | Trustee | 2 | $0 | $0 | $0 | $0 |
| Hei Hei Depew | Employee & Trustee | 2 | $94.8K | $0 | $25K | $119.8K |
| Hernan J Saenz | Trustee | 2 | $0 | $0 | $0 | $0 |
| Hon Stephen C Robinson | Trustee | 2 | $0 | $0 | $0 | $0 |
| Howard L Morgan | Trustee | 2 | $0 | $0 | $0 | $0 |
| Howard P Milstein | Trustee | 2 | $0 | $0 | $0 | $0 |
| J Allen Smith | Trustee | 2 | $0 | $0 | $0 | $0 |
| Jennifer L Davis | Trustee | 2 | $0 | $0 | $0 | $0 |
| Jessica M Bibliowicz | Trustee | 2 | $0 | $0 | $0 | $0 |
| Jia Zhu | Trustee | 2 | $0 | $0 | $0 | $0 |
| John Ceriale | Trustee | 2 | $0 | $0 | $0 | $0 |
| John R Toohey-Morales | Trustee | 2 | $0 | $0 | $0 | $0 |
| Jp Swenson | Student & Trustee | 2 | $0 | $0 | $0 | $0 |
| K Lisa Yang | Trustee | 2 | $0 | $0 | $0 | $0 |
| Kathy Hochul | Trustee & Governor | 2 | $0 | $0 | $0 | $0 |
| Katrina E James | Co-vice Chairman | 2 | $0 | $0 | $0 | $0 |
| Kevin Jacobs | Trustee | 2 | $0 | $0 | $0 | $0 |
| Kevin Johnson | Trustee | 2 | $0 | $0 | $0 | $0 |
| Kimberly A Wagner | Trustee | 2 | $0 | $0 | $0 | $0 |
| Kimberly N Dowdell | Trustee | 2 | $0 | $0 | $0 | $0 |
| Kraig H Kayser | Chairman | 2 | $0 | $0 | $0 | $0 |
| Linda M Gadsby | Trustee | 2 | $0 | $0 | $0 | $0 |
| Mario Cilento | Trustee | 2 | $0 | $0 | $0 | $0 |
| Martin F Scheinman Esq | Trustee | 2 | $2,000 | $0 | $0 | $2,000 |
| Mary Armstrong Meduski | Trustee | 2 | $0 | $0 | $0 | $0 |
| Matthew L Biben | Trustee | 2 | $0 | $0 | $0 | $0 |
| Michael L Thompson | Trustee | 2 | $0 | $0 | $0 | $0 |
| Paul D Rubacha | Trustee | 2 | $0 | $0 | $0 | $0 |
| Peggy J Koenig | Co-vice Chairman | 2 | $0 | $0 | $0 | $0 |
| Peter R Call | Trustee | 2 | $0 | $0 | $0 | $0 |
| Rebecca Robertson | Trustee | 2 | $0 | $0 | $0 | $0 |
| Reuben A Munday | Trustee | 2 | $0 | $0 | $0 | $0 |
| Richard S Emmet | Trustee | 2 | $0 | $0 | $0 | $0 |
| Robert Jain | Trustee | 2 | $0 | $0 | $0 | $0 |
| Robert W Selander | Trustee | 2 | $0 | $0 | $0 | $0 |
| Susan C Schnabel | Trustee | 2 | $0 | $0 | $0 | $0 |
| Valisha Graves | Trustee | 2 | $0 | $0 | $0 | $0 |
| William J Lipinski | Trustee | 2 | $0 | $0 | $0 | $0 |
| William Lim | Trustee | 2 | $0 | $0 | $0 | $0 |
Ana G Pinczuk
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Andrea Stewart-Cousins
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Anne Meinig Smalling
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Aryan Shayegani Md
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Beth Anderson
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Bradley H Stone
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Bruce S Raynor
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Carl E Heastie
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Dale S Rosenthal
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Dan Bromberg
Graduate Student & Trustee
$31.2K
Hrs/Wk
2
Compensation
$31.2K
Related Orgs
$0
Other
$0
David J Breazzano
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
David R Lee
Professor & Trustee
$2,414
Hrs/Wk
2
Compensation
$1,207
Related Orgs
$0
Other
$1,207
Deborah J Arrindell
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Doug Mitarotonda
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Eldora Ellison
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Enrique J Vila-Biaggi
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Eric Kutcher
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Ezra Cornell
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Gary S Davis
Co-vice Chairman
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Gilda Perez-Alvarado
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Girish V Reddy
Trustee
$0
Hrs/Wk
0.2
Compensation
$0
Related Orgs
$0
Other
$0
Harriet P Schleifer
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Hei Hei Depew
Employee & Trustee
$119.8K
Hrs/Wk
2
Compensation
$94.8K
Related Orgs
$0
Other
$25K
Hernan J Saenz
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Hon Stephen C Robinson
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Howard L Morgan
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Howard P Milstein
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
J Allen Smith
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Jennifer L Davis
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Jessica M Bibliowicz
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Jia Zhu
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
John Ceriale
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
John R Toohey-Morales
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Jp Swenson
Student & Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
K Lisa Yang
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Kathy Hochul
Trustee & Governor
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Katrina E James
Co-vice Chairman
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Kevin Jacobs
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Kevin Johnson
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Kimberly A Wagner
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Kimberly N Dowdell
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Kraig H Kayser
Chairman
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Linda M Gadsby
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Mario Cilento
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Martin F Scheinman Esq
Trustee
$2,000
Hrs/Wk
2
Compensation
$2,000
Related Orgs
$0
Other
$0
Mary Armstrong Meduski
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Matthew L Biben
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Michael L Thompson
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Paul D Rubacha
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Peggy J Koenig
Co-vice Chairman
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Peter R Call
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Rebecca Robertson
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Reuben A Munday
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Richard S Emmet
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Robert Jain
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Robert W Selander
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Susan C Schnabel
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Valisha Graves
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
William J Lipinski
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
William Lim
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0