University Of Notre Dame Du Lac

TAS::89 0227::TAS RECOVERY; RECOVERY ACT - MATERIALS SCIENCE OF ACTINIDES -- EFRC; PI - PETER BURNS

RAFIATION AND PHOTOCHEMISTRY IN THE CONDENSED PHASE

PFC: JOINT INSTITUTE FOR NUCLEAR ASTROPHYSICS, JINA

CENTER FOR SHOCK WAVE-PROCESSING OF ADVANCED REACTIVE MATERIALS (C-SWARM)

STRONG BEGINNINGS: LEVERAGING THE HOME, SCHOOL, AND CHURCH TO DEVELOP THE WHOLE CHILD IN HAITI.

MOUNTAIN TERRAIN ATMOSPHERIC MODELING AND OBSERVATIONS (MATERHORN)PROGRAM

QUARKNET

NUCLEAR STRUCTURE AND NUCLEAR ASTROPHYSICS

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

NUCLEAR STRUCTURE AND NUCLEAR ASTROPHYSICS

READ HAITI: SCALING EARLY GRADE READING IMPROVEMENT IN HAITI

III-N DEVICES AND ARCHITECTURES FOR TERAHERTZ ELECTRONICS

NUCLEAR STRUCTURE AND NUCLEAR ASTROPHYSICS

TAS::89 0336::TAS RECOVERY GLOBAL WARMING POTENTIAL (GWP) OF CURRENT REFRIGERANTS IS MORE THAN 1000 TIMES THE GWP OF CO2. THIS MAKES CO2 VERY ATTR

TAS::89 0336::TAS RECOVERY A RECENT DISCOVERY BY NOTRE DAME HAS IDENTIFIED A CLASS OF IONIC LIQUID MATERIALS WHICH UNDERGO A PHASE TRANSITION FROM

NOVEL OXADIAZOLS FOR THE TREATMENT OF DRUG-RESISTANT GRAM-POSITIVE BACTERIA

BROAD AGENCY ANNOUNCEMENT (BAA) UNDER THE MEDIA LITERACY FOR NEW DIGITAL ARRIVALS

"(HEL-MRI FY07) AIRBORNE AERO-OPTICS LABORATORY (AAOL)"

NUCLEAR STRUCTURE AND NUCLEAR ASTROPHYSICS

(R)-ND-336 FOR THE TREATMENT OF DIABETIC FOOT ULCERS

NOTRE DAME STUDY OF RESILIENCY IN LATER LIFE

TAS::57 3600::TAS "AIRBORNE AERO-OPTICS LABORATORY-TRANSONIC (AAOL-T)" DATED, 01 FEB 2012 AND REVISED BUDGET 14 SEP 2012"

MOLECULAR PROBES FOR BIOMEMBRANE RECOGNITION

BIOLOGICALLY-INSPIRED CNN IMAGE PROCESSORS WITH DYNAMICALLY-INTEGRATED HYPERSPECTRAL NANOSCALE SENSORS

INTERACTIONS REGULATING TRANSLATION AND PROTEIN BIOGENESIS IN VIVO

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

PENICILLIN-BINDING PROTEINS, MECHANISM AND INHIBITION

QUARKNET

CHEMISTRY-BIOCHEMISTRY-BIOLOGY INTERFACE TRAINING PROGRAM AT NOTRE DAME

RESEARCH WITH THE CMS DETECTOR AT THE LHC

RESISTANCE TO CARBAPENEM ANTIBIOTICS IN ACINETOBACTER BAUMANNII

QUARKNET

TRAFFICKING SIGNALS IN P. FALCIPARUM

COMPARATIVE TRANSCRIPTOMIC AND EPIGENOMIC ANALYSES OF MULLER GLIA REPROGRAMMING

THE QUINAZOLINONE CLASS OF ANTIBACTERIAL AGENTS

AIRBORNE AERO-OPTICS LABORATORY-BEAM CONTROL

DIAPAUSE IN CULEX MOSQUITOES

FOSTERING HEALTHY DEVELOPMENT AMONG MALTREATED PRESCHOOL-AGED CHILDREN

NETHEALTH: MODELING THE CO-EVOLUTION OF SOCIAL NETWORKS AND HEALTH BEHAVIORS

RESEARCH WITH THE CMS DETECTOR AT THE LHC

E2CDA: TYPE I: EXTREMELY ENERGY EFFICIENT COLLECTIVE ELECTRONICS (EXCEL)

AIR-SEA COUPLING IN MONSOON INTRASEASONAL OSCILLATIONS

AMINOGLYCOSIDE RESISTANCE IN ENTEROCOCCI

CHAPERONE THERAPEUTICS FOR THE TREATMENT OF DPN

MECHANISMS OF ERYTHROCYTIC INFECTION & ANEMIA IN MALARIA

DEVELOPING ANTI-VIRAL RIBOZYMES TO SUPPRESS ARBOVIRUSES IN TRANSGENIC MOSQUITOES

NEW COOPERATIVE AGREEMENT IONIC LIQUIDS: BREAKTHROUGH ABSORPTION TECHNOLOGY FOR POST COMBUSTION CO2 CAPTURE

BIOMATERIALS AND FIXATION METHODS DEVELOPMENT FOR TRAUMATIC ORTHOPAEDIC INJURIES

NEW GK-12: THE NOTRE DAME EXTENDED RESEARCH COMMUNITY (NDERC)

CHILDREN AND POLITICAL VIOLENCE IN NORTHERN IRELAND

DESIGN/SYNTHESES/STUDIES/NOVEL ANTITUBERCULOSIS AGENTS

BEST DATA COLLECTION VALIDATION AND RESEARCH

RESEARCH IN COLLIDER PHYSICS

DIAGONAL CAPILLARY ELECTROPHORESIS FOR PHOSPHORYLATION AND SIALYLATION ANALYSIS

QUIC-TAQS: DETERMINISTICALLY PLACED NUCLEAR SPIN QUANTUM MEMORIES FOR ENTANGLEMENT DISTRIBUTION

FORECASTING SPREAD AND BIOECONOMIC IMPACTS OF AQUATIC INVASIVE SPECIES FROM MULTIPLE PATHWAYS TO IMPROVE MANAGEMENT AND POLICY IN THE GREAT LAKES.

MRI: ACQUISITION OF AN ACCELERATOR FOR STELLAR NUCLEOSYNTHESIS MEASUREMENTS

RESEARCH IN COLLIDER PHYSICS

EFFECTS OF AGRICULTURAL EXPANSION AND INTENSIFICATION ON INFECTIONS

PHYSICAL BASIS FOR T CELL RECEPTOR BINDING AND ACTIVITY

DIANA, A NOVEL NUCLEAR ACCELERATOR LAB UNDERGROUND

FUNCTIONAL GENOMICS OF INVERSION 2LA IN ANOPHELES GAMBIAE

GOLD NANOCRYSTAL ANTIBIOTICS FOR THE TREATMENT OF MULTIDRUG-RESISTANT GRAM NEGATI

PHARMACOLOGICAL BLOCKAGE OF XBP-1S EXPRESSION IN CANCER

BLOOD COAGULATION PROTEIN-METAL ION-LIPID INTERACTIONS

IDENTIFICATION OF KIDNEY REGENERATION MECHANISMS USING THE ZEBRAFISH

DESIGN AND USE OF NOVEL BACTERIOCINS

UPWARD BOUND

AIRBORNE AERO-OPTICS LABORATORY - TRANSONIC (AAOL-T)

JOINT INSTITUTE FOR NUCLEAR ASTROPHYSICS - JINA

M. AVIUM GPLS IN MACROPHAGE ACTIVATION AND VIRULENCE

CONTROL OF VECTOR-BORNE DISEASES: DEVELOPMENT OF HUMAN-SAFE INSECTICIDES FOR US MILITARY PROTECTION AND IMPROVING GLOBAL HEALTH II

DATA AND SOFTWARE PRESERVATION FOR OPEN SCIENCE (DASPOS)

REGULATION OF OVARIAN CARCINOMA PROTEINASES

TALENT SEARCH PROGRAM

TALENT SEARCH PROGRAM

NORTHWEST INDIANA COMPUTATIONAL GRID (NWIC-GRID)

EFRI 2-DARE: MONOLAYER HETEROSTRUCTURES: EPITAXY TO BEYOND-CMOS DEVICES

DIMENSIONS US-CHINA: INTEGRATING THE DIMENSIONS OF BIODIVERSITY TO UNDERSTAND TREE PERFORMANCE IN A CHANGING WORLD

INFLUENCE OF TRANSLATION ON PROTEIN FOLDING

IONIC LIQUIDS FOR THE UTILIZATION OF GEOTHERMAL ENERGY

TUBOVESICULAR TRAFFIC INDUCED IN RED CELLS IN PLASMODIA

RESEARCH IN COLLIDER PHYSICS

IGERT: GLOBAL LINKAGES OF BIOLOGY, ENVIRONMENT, AND SOCIETY (GLOBES)

MATURATION OF BACTERIAL CELL WALL

RTG: GEOMETRY AND TOPOLOGY

DETERMINANTS OF GROWTH AND FITNESS IN DRUG RESISTANT MALARIA PARASITES

CLASS A CARBAPENEMASES

NEW; TITLE: IN SITU CORRELATED MOLECULAR IMAGING OF CHEMICALLY COMMUNICATING MICROBIAL COMMUNITIES; PI: PAUL BOHN

DIANA, AN UNDERGROUND ACCELERATOR FACILITY FOR NUCLEAR ASTROPHYSICS

CCI PHASE I: NSF CENTER FOR COMPUTER ASSISTED SYNTHESIS

TAS::89 0321::TAS CDP TO NOTRE DAME UNIVERSITY FOR PASSIVE NOX REMOVAL CATALYST RESEARCH.

PATHOPHYSIOLOGIES INVOLVING HEMOSTASIS-RELATED GENES

MULTI-SCALE SEPARATION AND ANALYSIS OF HETEROGENEOUS TRINITE PHASES ANTONIO SIMONETTI, P.I.

PROTEOSTATIC MECHANISMS OF RESISTANCE IN MALARIA

GENERATION OF NOVEL MODELS OF KIDNEY DEFECTS USING THE ZEBRAFISH

UPWARD BOUND PROGRAM

DEVELOPMENT AND EVALUATION OF PURINE AND COUMARIN BASED HSP90 INHIBITORS

MOLECULAR ASPECTS OF TRANSPORT IN THIN FILMS OF CONTROLLLED ARCHITECTURE

NEB: PHYSICS-INSPIRED NON-BOOLEAN COMPUTATION BASED ON SPATIAL- TEMPORAL WAVE EXCITATIONS

COLLABORATIVE RESEARCH AND NEON: MSB CATEGORY 2: PALEON - A PALEOECOLOGICAL OBSERVATORY NETWORK TO ASSESS TERRESTRIAL ECOSYSTEM MODELS

QUANTITATIVE PROTEOMICS OF XENOPUS OOCYTES, EGGS, BLASTOMERES, AND NUCLEAR TRANSPLANTS

CDI-TYPE II: BUILDING AND STUDYING A VIRTUAL ORGANIZATION FOR ADAPTATION TO CLIMATE CHANGE

SP-MIMO RADAR STUDIES

NEB: NANOELECTRONICS WITH MIXED-VALENCE MOLECULAR QCA

DEVELOPMENT OF HSP90 INHIBITORS FOR THE TREATMENT OF CANCER

ENGINEERING OF OXIDE/NITRIDE STRUCTURES (EONS)

HYBRID ENCAPSULATED IONIC LIQUIDS FOR POST-COMBUSTION CARBON DIOXIDE CAPTURE

PROTO-OKN THEME 1: EXPLOITING FEDERAL DATA AND BEYOND: A MULTI-MODAL KNOWLEDGE NETWORK FOR COMPREHENSIVE WILDLIFE MANAGEMENT UNDER CLIMATE CHANGE -THIS PROTOTYPE-OPEN KNOWLEDGE NETWORK PROJECT SEEKS TO CREATE A COMPREHENSIVE, INTEGRATIVE KNOWLEDGE NETWORK FOR THE MANAGEMENT OF WILDLIFE IN THE CONTEXT OF CLIMATE CHANGE, CALLED KN-WILDLIFE. EFFECTIVE WILDLIFE MANAGEMENT IS ESSENTIAL FOR SAFEGUARDING BIODIVERSITY, ECOSYSTEM HEALTH, AND ECONOMIC STABILITY OF ANY REGION. THE LOOMING THREAT OF CLIMATE CHANGE CAN DISRUPT THE DISTRIBUTION, BEHAVIOR, AND POPULATION DYNAMICS OF MANY SPECIES, PARTICULARLY THOSE THAT ARE INVASIVE OR THREATENED OR ECONOMICALLY IMPORTANT. WHILE SPECIES DISTRIBUTION MODELS (SDMS) HAVE BEEN USED TO PREDICT SPECIES RESPONSES TO CLIMATE CHANGE, THEIR PREDICTIVE CAPABILITY CAN BE HAMPERED BY THE OMISSION OF SEVERAL INFLUENCING FACTORS LIKE INTERSPECIES COMPETITION, CHANGES IN LAND USE, OR THE MIGRATION ABILITY OF VARIOUS SPECIES. A NUMBER OF DATA SOURCES ARE AVAILABLE THAT ARE RELEVANT TO THESE CONSIDERATIONS INCLUDING THE UNITED STATES GEOLOGICAL SURVEY (USGS), THE GLOBAL BIODIVERSITY INFORMATION FACILITY, AND THE IUCN RED LIST OF THREATENED SPECIES. HOWEVER, THE EFFECTIVE USE OF THESE DATA IS CURRENTLY IMPEDED BY FACTORS ASSOCIATED WITH THE HETEROGENEITY, SPATIAL AND TEMPORAL DISCREPANCIES, AND VARYING QUALITY AND COMPLETENESS OF THE DATA. KN-WILDLIFE WILL ADDRESS THIS PROBLEM BY PROVIDING AN OPEN-ACCESS PLATFORM THAT COUPLES DATA WITH VISUALIZATION TOOLS AND PREDICTIVE MODELS TO DISTILL COMPLEX MULTIMODAL DATA INTO AN INTUITIVE, UNIFIED REPRESENTATION OF MANAGED SPECIES. KN-WILDLIFE WOULD HELP INFORM DECISION-MAKING PROCESSES AND WHILE PROVIDING STAKEHOLDERS WITH ACTIONABLE INSIGHTS. THE PROJECT WILL BEGIN BY PROVIDING COMPREHENSIVE KNOWLEDGE AND PREDICTIVE MODELS FOR SPECIES OF CONCERN TO STAKEHOLDERS IN THESE TWO US STATES, VIZ., INDIANA AND FLORIDA. PROJECT COLLABORATORS INCLUDE STAKEHOLDERS FROM THE FISH AND WILDLIFE COMMISSIONS (FWC) AND DEPARTMENTS OF HEALTH (DOH) FROM BOTH OF THESE STATES. KN-WILDLIFE WILL INITIALLY FOCUS ON AROUND 3,000 MANAGED SPECIES OF INTEREST TO THE STAKEHOLDERS, ENCOMPASSING A BROAD TAXONOMY FROM FUNGI AND BACTERIA TO FISH AND MAMMALS. WORKING IN COLLABORATION WITH THE LUCY FAMILY INSTITUTE AT THE UNIVERSITY OF NOTRE DAME, THE PROJECT WILL INTEGRATE USE OF KN-WILDLIFE INTO THE NSF-FUNDED INTERDISCIPLINARY TRAINEESHIP FOR SOCIALLY RESPONSIBLE AND ENGAGED DATA SCIENTISTS (ITREDS) PROGRAM AND THE SUMMER EDUCATION AND ENGAGEMENT FOR DATA SCIENCE (SEEDS) PROGRAM. THESE INITIATIVES ARE SPECIFICALLY DESIGNED TO PROVIDE UNDERGRADUATE DATA SCIENCE TRAINING CENTERED ON SOCIETAL CHALLENGES, AND ALSO PROVIDE K-12 TRAINING OPPORTUNITIES FOR THOSE FROM UNDER-RESOURCED SCHOOLS AND COMMUNITIES. ALL KN-WILDLIFE RESOURCES WILL BE PUBLICLY AVAILABLE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

RECODE: VASCULAR DIFFERENTIATION AND MORPHOGENESIS CONTROLLED WITH HYBRID MEMRISTORS -HOW GROUPS OF STEM CELLS DIFFERENTIATE AND FORM PATTERNED BLOOD VESSELS REMAINS AN UNRESOLVED MYSTERY. SOLVING THIS CHALLENGE WILL BROADLY ADVANCE THE GROWING TISSUE ENGINEERING INDUSTRY, WHICH PRODUCES IMPLANTABLE TISSUES AND ORGANS. PRESENT METHODS FOR STEM CELL DIFFERENTIATION ARE COSTLY AND INEFFICIENT. ADDITIONALLY, MANUFACTURING THREE-DIMENSIONAL TISSUES WITH PRECISION IS AN UNMET CHALLENGE. THIS RECODE PROJECT WILL DEVELOP AND TEST A NEW PLATFORM THAT CONTROLS ELECTRICAL AND CHEMICAL SIGNALING TO DIFFERENTIATE STEM CELLS INTO PATTERNED BLOOD VESSEL NETWORKS. THIS PROJECT WILL IMPACT THE BIOMEDICAL COMMUNITY THROUGH RESEARCH FINDINGS AND EDUCATION AND OUTREACH ACTIVITIES. THE TEAM WILL ORGANIZE A MULTIDISCIPLINARY CONFERENCE AT THE INTERFACE BETWEEN MULTIPLE FIELDS OF BIOLOGY AND ENGINEERING. TO SUPPORT TRAINEES FROM UNDERREPRESENTED GROUPS, TRAVEL AWARDS WILL BE PROVIDED TO COVER THEIR COSTS TO ATTEND THE CONFERENCE. TOWARD DIVERSIFYING THE STEM WORKFORCE, UNDERGRADUATE STUDENTS FROM DIVERSE DEMOGRAPHIC BACKGROUNDS WILL BE RECRUITED FOR SUMMER AND SEMESTER RESEARCH PROJECTS. THE OVERALL GOAL OF THIS RECODE PROJECT IS TO EXPLORE THE FUNDAMENTAL MECHANISMS OF HOW CELL SIGNALING AND PHYSIOLOGY REGULATE STEM CELL DIFFERENTIATION AND VASCULARIZATION. TO ACHIEVE THIS GOAL, THE MULTIDISCIPLINARY RESEARCH TEAM WILL ENGINEER THE FIRST AUTONOMOUS HYBRID MEMORY RESISTOR (MEMRISTOR) AND CELL CULTURE DEVICE TO CONTROL THE DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS INTO ENDOTHELIAL CELLS AND THEIR MORPHOGENESIS INTO MATURE VASCULAR NETWORKS. SUCH AN ACHIEVEMENT WILL HAVE BROAD IMPLICATIONS IN BOTH DEVELOPMENTAL BIOLOGY AND REGENERATIVE MEDICINE. THE PLATFORM TECHNOLOGY WILL INVOLVE EMBEDDING AN ARTIFICIAL NEURONAL NETWORK THAT INCLUDES MEMRISTOR CIRCUITS TO CONCENTRATE AND PATTERN EXTRACELLULAR SIGNALS AND COORDINATE THE INTRACELLULAR OSCILLATIONS BETWEEN COMMUNICATING CELLS. THE MULTIDISCIPLINARY RESEARCH TEAM WILL DESIGN THIS MEMRISTOR CIRCUIT TO SYNERGIZE WITH AN EXPANDING SYNTHETIC BIOLOGY TOOLKIT THAT INCLUDES CONTROLLING CELL SIGNALING AND DIFFERENTIATION WITH LIGHT, SYNTHETIC HYDROGELS, QUANTITATIVE AND DYNAMIC BIOMARKER MEASUREMENTS, MOLECULAR MANIPULATION, AND MACHINE LEARNING ALGORITHMS. EXPECTED OUTCOMES INCLUDE A DEEPER MECHANISTIC UNDERSTANDING OF HOW CHEMICAL AND PHYSIOLOGICAL SIGNALING INFLUENCES THE DIFFERENTIATION AND FORMATION OF VASCULAR NETWORKS AND NEW METHODS FOR THE ROBUST, REPRODUCIBLE, AND SCALABLE PRODUCTION OF DIFFERENTIATED CELL TYPES. THIS RECODE PROJECT IS JOINTLY FUNDED BY THE ENGINEERING BIOLOGY AND HEALTH CLUSTER IN THE DIVISION OF CHEMICAL, BIOENGINEERING, ENVIRONMENTAL, AND TRANSPORT SYSTEMS, AND THE PHYSIOLOGICAL MECHANISMS AND BIOMECHANICS PROGRAM AND ANIMAL DEVELOPMENTAL MECHANISMS PROGRAM IN THE DIVISION OF INTEGRATIVE ORGANISMAL SYSTEMS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

INTERVENTION OF DISEASE BY SELECTIVE GELATINASE INHIBITORS

DEVICES AND ARCHITECTURES FOR TERAHERTZ ELECTRONICS

REU SITE: PHYSICS REU AND RET PROGRAMS AT THE UNIVERSITY OF NOTRE DAME

GLYCOLIPID METABOLISM IN SINGLE CELLS

CDI-TYPE II: OPEN SOURCING THE DESIGN OF CIVIL INFRASTRUCTURE (OSD-CI)

TOWARDS REALISTIC MODELS OF HETEROGENEOUS CATALYSIS: SIMULATIONS OF REDOX ...

MOLECULAR MECHANISMS OF CELL INVASION

FUNCTION OF INHIBITOR OF DNA BINDING (ID) GENES IN THE CIRCADIAN SYSTEM

META-OPTICS ENABLED MULTIFUNCTIONAL IMAGING

NEW PARADIGMS FOR HSP90 INHIBITION

(PQD-3) SPATIOTEMPORAL MOLECULAR INTERROGATION OF EARLY METASTATIC EVOLUTION IN SITU

REU/RET SITE: PHYSICS REU AND RET PROGRAMS AT THE UNIVERSITY OF NOTRE DAME

REU SITE: PHYSICS REU AND RET PROGRAMS AT THE UNIVERSITY OF NOTRE DAME

FORCASTING SPREAD AND BIOECONOMIC IMPACTS OF AQUATIC INVASIVE SPECIES FROM MULTIPLE PATHWAYS TO IMPROVEMAAGEMENT AND POLICY IN THE GREAT LAKES (PART

TAS::97 0400::TAS "(DARPA) - ENSEMBLE-BASED MODELING OF LARGE GRAPHS AND ITS APPLICATIONS TO SOCIAL NETWORKS"

PHOTO-INITIATED CARTILAGE CROSSLINKING AS A PREVENTATIVE FOR POST-TRAUMATIC OSTEOARTHRITIS

GENETIC HIERARCHY UNDERLYING PHOTORECEPTOR REGENERATION

FUNCTIONAL MOTIONS OF MODULAR SIGNALING PROTEINS

AN EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION OF NEXT-GENERATION CASING TREATMENTS FOR FRONT-STAGE

CIF: MEDIUM: MODELING, ANALYSIS, AND CODE DESIGN FOR PORTABLE WIRELESS DEVICE TRANSMITTERS SUBJECT TO AN ELECTROMAGNETIC EXPOSURE CONSTRAINT

FINDING YOUR VOCATION IN STEM

TAS::57 3600::TAS 'HIGH REYNOLDS NUMBER QUIET MACH 6 NOZZLE FABRICATION AND NATURAL TRANSITION EXPERIMENTS' DATED: 16 FEB 2017'

NUCLEAR REACTION AND STRUCTURE STUDIES WITH RADIOACTIVE AND STABLE BEAMS

EMSW21-RTG: NOTRE DAME'S MATHEMATICAL LOGIC PROGRAM

ENABLING LONG TIMESTEP MOLECULAR DYNAMICS ON PARALLEL CPU AND GPU ENVIRONMENTS

THE RECIPIENT SHALL FURNISH THE NECESSARY QUALIFIED PERSONNEL, MATERIALS, FACILITIES, SUPPLIES AND SERVICES TO PERFORM RESEARCH IN ACCORDANCE WITH TH

IONIC LIQUIDS: BREAKTHROUGH ABSORPTION TECHNOLOGY FOR POST COMBUSTION CO2 CAPTURE

LABORATORY FOR ENGINEERING OF OXIDE/NITRIDE STRUCTURES

NUCLEAR ASTROPHYSICAL PROBES OF MATTER AT HIGHT TEMPERATUREAND DENSITY

COMBINED MULTISCALE MODELING AND EXPERIMENTAL STUDY OF BACTERIAL SWARMING

INTEGRATIVE COMPUTATIONAL FRAMEWORK FOR PATTERN MINING IN BIG -OMICS DATA: LINKING SYNONYMOUS CODON USAGE TO PROTEIN BIOGENESIS

ROLES OF TNFA AND NOTCH TO INITIATE RETINAL REGENERATION FROM MULLER GLIA

SYNTHESIS AND BIOSYNTHESIS OF PYRAN AND SPIROKETAL STRUCTURAL UNITS

INTERNAL WAVES AND MIXING IN THE EAST INDIAN COASTAL CURRENT OFF SRI LANKA

SEMISYNBIO: CARDIAC MUSCLE-CELL-BASED COUPLED OSCILLATOR NETWORKS FOR COLLECTIVE COMPUTING

OUTER MEMBRANE SECRETION MECHANISM FOR AUTOTRANSPORTER PROTEINS

TAS::89 0222::TAS INNOVATION PARK AT NOTRE DAME, SOUTH BEND, IN

COLLABORATIVE RESEARCH: EDGE FGT: GENOME-WIDE KNOCK-OUT MUTANT LIBRARIES FOR THE MICROCRUSTACEAN DAPHNIA -MUTATING THE DNA SEQUENCES OF GENES OF INTEREST IS A VALUABLE APPROACH FOR UNDERSTANDING THEIR BIOLOGICAL FUNCTIONS IN DIVERSE ORGANISMS. IN CONTRAST TO ESTABLISHED MODEL SYSTEMS, LARGE COLLECTIONS OF GENE KNOCK-OUT MUTANTS ARE NOT WIDELY AVAILABLE IN EMERGING MODEL ORGANISMS. THIS LIMITATION GREATLY DIMINISHES THE POWER OF EMERGING MODEL SYSTEMS FOR MAKING NOVEL SCIENTIFIC DISCOVERIES. TO ADDRESS THE ISSUE, THIS PROJECT WILL DEVELOP A LARGE COLLECTION OF GENE KNOCK-OUT MUTANTS USING CRISPR GENE EDITING IN THREE SPECIES OF THE FRESHWATER MICROCRUSTACEAN DAPHNIA (D. MAGNA, D. PULEX, AND D. PULICARIA), WHICH IS AN EMERGING MODEL SYSTEM IN ECOLOGICAL GENOMICS, EVOLUTIONARY GENOMICS, AND ENVIRONMENTAL GENOMICS. THE DAPHNIA KNOCK-OUT MUTANTS WILL PROVIDE UNPRECEDENTED OPPORTUNITIES FOR THE SCIENTIFIC COMMUNITY TO CHARACTERIZE THE BIOLOGICAL FUNCTIONS OF THE GENES. THE PROJECT WILL ALSO DISSEMINATE TECHNICAL EXPERTISE FOR CRISPR GENE EDITING IN DAPHNIA THROUGH FREE WORKSHOPS, TARGETING BIOLOGISTS AT DIFFERENT CAREER STAGES INCLUDING UNDERGRADUATES, GRADUATES, POSTDOCTORAL RESEARCHERS, AND FACULTY. FURTHERMORE, THE PROJECT WILL DEVELOP AN INNOVATIVE GENOMICS CURRICULUM TO ENABLE HANDS-ON RESEARCH IN THE CLASSROOM AND ENHANCE THE EDUCATION EXPERIENCE OF DIVERSE UNDERGRADUATE STUDENTS. THE PLAN IS TO KNOCK OUT GENES IN DAPHNIA, INCLUDING MANY CANDIDATE GENES THAT MAY PLAY CRITICAL ROLES IN ACCLIMATION, ADAPTATION, AND EVOLUTION OF THESE SPECIES. INDIVIDUAL KNOCK-OUT MUTANT LINES WILL BE GENERATED, MAINTAINED IN THE LABORATORY, AND FREELY SHARED WITH THE RESEARCH COMMUNITY. EACH MUTANT LINE WILL BE WHOLE-GENOME SEQUENCED TO CHARACTERIZE ITS GENOMIC BACKGROUND. IN COLLABORATION WITH THE GLOBAL DAPHNIA RESEARCH COMMUNITY, THIS PROJECT WILL EVALUATE THE FUNCTIONAL CHANGES IN KNOCK-OUT MUTANTS AT BOTH GENOMIC AND ORGANISM LEVELS TO VALIDATE THE ROLE OF THE GENES IN VARIOUS ENVIRONMENTAL SETTINGS AND TO INFER GENE INTERACTION AND GENE REGULATION NETWORKS. LASTLY, A FREE, PUBLIC-FACING DATABASE WILL BE DEVELOPED TO HOST THE GENOMIC AND PHENOTYPIC DATA OF THE MUTANT LINES, TO PROMOTE AND MANAGE THE DISTRIBUTION OF DAPHNIA MUTANTS, AND TO DISTRIBUTE EXPERIMENTAL PROTOCOLS AND REAGENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

RESEARCH IN CP VIOLATION IN THE B MESON SECTOR

MECHANISMS OF TARGETING TRIPLE-NEGATIVE BREAST CANCER GENOMIC VULNERABILITY

BEYOND BOREDOM: MODELING AND PROMOTING ENGAGEMENT DURING COMPLEX LEARNING

ECOLOGICAL GENOMICS OF ANOPHELES GAMBIAE

OPTIMIZATION AND INVESTIGATION OF CRUENTAREN A ANALOGS

CONTROL OF VECTOR-BORNE DISEASES: DEVELOPMENT OF HUMAN-SAFE INSECTICIDES FOR US MILITARY PROTECTION AND IMPROVING GLOBAL HEALTH

RESISTANCE TO BETA-LACTAM ANTIBIOTICS

SHF: MEDIUM: COLLABORATIVE RESEARCH: SEMANTICALLY-ENHANCED SOFTWARE TRACEABILITY FOR SUPPORTING HUMAN-CENTRIC TASKS

PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM

TAS::89 0222::TAS; NEW; TITLE: INORGANIC CONTROLS ON NEPTUNIUM MOBILITY IN THE SUBSURFACE; PI: PETER C. BURNS

COLLABORATIVE RESEARCH: DEVELOPING A MULTI-SCALE UNDERSTANDING OF MICROTUBULE DYNAMIC INSTABILITY

BUILDING COUPLED STORM SURGE AND WAVE OPERATIONAL FORECASTING CAPACITY FOR WESTERN ALASKA

DAPHNIA FUNCTIONAL GENOMICS RESOURCE

NEW; TOWARD AN IMPROVED UNDERSTANDING OF STRUCTURE AND MAGNETISM IN NEPTUNIUM AND PLUTONIUM PHOSPHONATES AND SULFONATES; PI: THOMAS ALBRECHT-SCHMITT

COUPLED AIR-SEA PROCESSES AND EM DUCTING RESEARCH (CASPER): EFFECTS OF ATMOSPHERIC BOUNDARY LAYER DYNAMICS ON PROPAGATION

BIGDATA: F: DKM: ADDRESSING THE TWO V'S OF VERACITY AND VARIETY IN BIG DATA

CPS: SYNERGY: RESILIENT WIRELESS SENSOR-ACTUATOR NETWORKS

DE-FE0031862, UNIVERSITY OF NOTRE DAME, TITLED ''PROCESS INTENSIFICATION BY A ONE-STEP, PLASMA-ASSISTED SYNTHESIS OF LIQUID CHEMICALS FROM LIGHT HYDROCARBONS.''

GENETIC ANALYSIS OF RETINAL DEGENERATION

PRECURSORS OF RETARDATION IN CHILDREN WITH TEEN MOTHERS

AMERICORPS*NATIONAL

COLLABORATIVE RESEARCH: MRA: EVALUATING HYPOTHESES OF LONG-TERM WOODY CARBON DYNAMICS WITH EMPIRICAL DATA -CHANGES IN THE VEGETATION OF THE AMERICAN UPPER MIDWEST OVER A TEN-THOUSAND YEAR PERIOD, BETWEEN THE END OF THE LAST ICE AGE AND THE 19TH CENTURY ARE RECORDED IN FOSSIL POLLEN BURIED IN THE SEDIMENTS OF LAKES, SWAMPS AND BOGS. IT IS NECESSARY TO USE THIS FOSSIL RECORD BECAUSE WRITTEN VEGETATION SURVEYS DID NOT BEGIN UNTIL THE INDUSTRIAL PERIOD. PAST INVESTIGATION OF THESE POLLEN ASSEMBLAGES HAS REVEALED SHIFTS IN VEGETATION WITH CLIMATE CHANGE (SUCH AS POST-GLACIAL WARMING) AND NATURAL DISTURBANCE (SUCH AS THE WILDFIRES THAT PREVENTED TREES FROM INVADING PRAIRIES). THIS PROJECT TAKES ADVANTAGE OF NEW STATISTICAL AND COMPUTER MODELING APPROACHES TO QUANTIFY POST-GLACIAL CHANGES IN MIDWESTERN VEGETATION AND CLIMATE IN TERMS THAT ARE USEFUL TO SOCIETY (CHANGES IN THE NUMBERS AND BIOMASS OF TREES ON THE LANDSCAPE OVER CENTURIES). BETTER QUANTIFICATION OF PRE-INDUSTRIAL MIDWESTERN VEGETATION IS IMPORTANT FOR TWO REASONS RELATED TO THIS PROJECT. FIRST, THE PRE-INDUSTRIAL LANDSCAPE IS A KEY BENCHMARK FOR: LAND MANAGERS (A BASELINE FOR CONSERVATION, TIMBER MANAGEMENT, ETC.); GLOBAL CHANGE RESEARCHERS (CHANGES IN PRE-INDUSTRIAL VEGETATION BIOMASS ARE AMONG THE MOST UNCERTAIN COMPONENTS OF THE GLOBAL CARBON CYCLE); AND THE PUBLIC (PRE-INDUSTRIAL VEGETATION HELPS DEFINE THE CHARACTER OF THE LAND). THIS PROJECT WILL ENGAGE WITH EACH OF THESE COMMUNITIES THROUGH: CONFERENCES, PUBLICLY-AVAILABLE RECONSTRUCTIONS OF THOUSANDS OF YEARS OF VEGETATION CHANGE, AND FREE, ONLINE EDUCATION MODULES THAT WILL BE TAUGHT TO A BROAD ARRAY OF STUDENTS, FROM HIGH-SCHOOLERS TO PROFESSIONAL RESOURCE MANAGERS. SECOND, BETTER QUANTIFICATION OF LONG-TERM VEGETATION FILLS A KEY GAP IN OUR BASIC UNDERSTANDING OF THE ECOLOGY OF VEGETATION CHANGE. RESEARCHERS KNOW THAT CHANGING CLIMATE AND DISTURBANCES, LIKE FIRE, CAN CHANGE VEGETATION SUDDENLY AND IRREVERSIBLY OVER LARGE AREAS, BUT THE ABSENCE OF WELL-QUANTIFIED RECORDS OF LONG-TERM VEGETATION CHANGE HAS BEEN AN OBSTACLE TO ECOLOGICAL UNDERSTANDING OF HOW AND WHEN SUCH CHANGES ACTUALLY OCCUR. THIS PROJECT USES AN INTEGRATED MODELING FRAMEWORK TO ENSURE THAT THE NEW RECONSTRUCTIONS OF VEGETATION CHANGES, WHICH SPAN CENTURIES OF TREE-LIFETIMES, WILL COMPLEMENT THE EXISTING UNDERSTANDING OF VEGETATION CHANGE, WHICH IS PRIMARILY BASED ON DATA ONLY COLLECTED OVER RECENT DECADES. IN ADDITION TO THE CONFERENCES, PUBLIC OUTREACH AND ONLINE TRAINING, THIS PROJECT WILL ALSO EDUCATE AND TRAIN 4 GRADUATE STUDENTS IN QUANTITATIVE PALEO-ECOLOGY. THE PROJECT BUILDS ON AND IMPROVES A RECENTLY-DEVELOPED STATISTICAL MODEL OF CHANGES IN ABOVEGROUND WOODY BIOMASS POOLS (AGWB) ACROSS THE MIDWEST OVER THE LAST 10,000 YEARS. THESE RECONSTRUCTIONS OF AGWB OVER SPACE AND TIME ARE THE DATA THAT TEST A SET OF HYPOTHESES ABOUT MIDWESTERN VEGETATION HISTORY CENTERED ON THE OVERALL QUESTION OF WHETHER INTERNAL FEEDBACKS (FOR EXAMPLE BETWEEN VEGETATION AND WILDFIRE) PLAYED IMPORTANT ROLES IN STABILIZING OR DESTABILIZING THE RESPONSE OF AGWB TO CHANGING CLIMATES OVER THE HOLOCENE, AND WHETHER MODERN LAND-USE HAS ALTERED THESE FEEDBACKS SIGNIFICANTLY. THE PROJECT WILL MAKE JOINT PROBABILISTIC INFERENCE ABOUT CHANGING BIOMASS POOLS, DEMOGRAPHIC RATES IN FORESTS, AND CLIMATE DRIVERS CONSTRAINED BY THE AGWB RECONSTRUCTIONS, AN ENSEMBLE OF MODELED HOLOCENE CLIMATE TRAJECTORIES, AND ALTERNATIVE MODELS OF THE ECOLOGICAL PROCESS OF FOREST CHANGE. NONLINEAR THRESHOLD RESPONSES OF VEGETATION TO CLIMATE ARE A SPECIAL FOCUS OF THESE RETROSPECTIVE ?HINDCASTS?. THE QUANTITATIVE TOOLS DEVELOPED IN THE PROJECT UNDERLIE EDUCATION AND OUTREACH PROGRAMS TO STUDENTS, LAND MANAGERS, AND OTHER RESEARCHERS THROUGH EXERCISES, MODULES, AND CURRICULA THAT THE RESEARCHERS WILL TEST-DRIVE IN A DIVERSE SET OF SHORT COURSES, THEN MADE AVAILABLE TO THE PUBLIC ONLINE. TRAINING OF FOUR GRADUATE STUDENTS WILL ALSO BE INTERWOVEN WITH THE RESEARCH AND OUTREACH OBJECTIVES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

DISTRIBUTED SPECTRUM SENSING WITH COLLABORATIVE AND RESPONSIVE NODES (ARL PARAGRAPH 1.2.6 - DR. JOE QIU)

ANALYSIS OF HOST OBESITY AND THERAPEUTIC RESPONSE IN OVARIAN CANCER

IONIC LIQUIDS FOR THE UTILIZATION OF GEOTHERMAL ENERGY

PREEVENTS TRACK 2: COLLABORATIVE RESEARCH: SUBGRID-SCALE CORRECTIONS TO INCREASE THE ACCURACY AND EFFICIENCY OF STORM SURGE MODELS

HIGH-THROUGHPUT ELECTROKINETIC FRACTIONATION AND ANALYSIS OF EXTRACELLULAR RNA NANO-CARRIERS

X-RAY AND CHEMICAL STUDIES OF METALLOPORPHYRINS

GAANN: MATERIALS ENGINEERING TO REALIZE INNOVATIVE TECHNOLOGIES FOR SUSTAINABILITY (MERITS) FELLOWS TRAINING PROGRAM

DMREF: COLLABORATIVE RESEARCH: GOALI: MULTISCALE DESIGN OF ZEOLITE SITES FOR PRECISE CATALYTIC TRANSFORMATIONS

CPS: TTP OPTION: SYNERGY: COLLABORATIVE RESEARCH: DEPENDABLE MULTI-ROBOT COOPERATIVE TASKING IN UNCERTAIN AND DYNAMIC ENVIRONMENTS

SLEEP AND SELECTIVE EMOTIONAL MEMORY CONSOLIDATION FROM YOUNG ADULTHOOD THROUGH MIDDLE AGE

BIOMAPS: EXPERIMENTAL AND COMPUTATIONAL STUDIES OF MICROTUBULE DYNAMICS AND REGULATION BY BINDING PROTEINS

NEESR-CR: POST-TENSIONED COUPLED SHEAR WALL SYSTEMS

(DURIP 15) "LARGE HYPERSONIC QUIET TUNNEL: DRIVER TUBE AND AIR SUPPLY"

EDUCATION RESEARCH PROGRAM

CONFORMATIONAL FLEXIBILITY AND ANTIBIOTIC RESISTANCE

IMPROVING CYBERCRIME KNOWLEDGE AND FORENSIC SKILLS

CHILD LABOR

ROBUST DIAGNOSIS IN ELECTRONIC HEALTH RECORDS INTEGRATING PHYSICS-BASED MISSING DATA MULTIPLE IMPUTATION, FAST INFERENCE FOR HEMODYNAMIC MODELS, AND DIFFERENTIAL PRIVACY.

COLLABORATIVE RESEARCH: REGULATION OF LAKE PRODUCTIVITY BY TERRESTRIAL DISSOLVED ORGANIC MATTER

INTEGRATING MULTISCALE MODELING AND IN VIVO EXPERIMENTS FOR STUDYING BLOOD CLOT DEVELOPMENT

EFFECTIVE INTERFERING RNA LURE-AND-KILL-BAITED OVITRAPS FOR BIORATIONAL AEDES ZIKA VECTOR MOSQUITO CONTROL

PREDICTING THE IMPACT OF CLIMATE CHANGE ON ANIMAL DISTRIBUTIONS: THE IMPORTANCE OF LOCAL ADAPTATION AND SPECIES TRAITS

COUPLED TRANSPORT AND REACTIONS IN LOW-DIMENSIONAL NANOFLUIDIC STRUCTURES FOR ENHANCED CHEMICAL MEASUREMENTS

ELECTRON SPIN EFFECTS IN SEMICONDUCTOR NANOSTRUCTURES

NEW; REACTION FIELD MODEL FOR TREATMENT OF SOLVATION IN ELECTRONIC STRUCTURE CALCULATIONS; PI: DANIEL CHIPMAN

TRIO - TALENT SEARCH - TALENT SEARCH PROGRAM

MRI: ACQUISITION: ESTABLISHMENT OF THE MIDWEST ISOTOPE AND TRACE ELEMENT RESEARCH ANALYTICAL CENTER (MITERAC)

MOLECULAR ASPECTS OF TRANSPORT IN THIN FILMS OF CONTROLLLED ARCHITECTURE

SOCS: EXPLORATIONS ON THE EFFECTS OF PERVASIVE NETWORKING ON SOCIAL RELATIONSHIPS AND RESOURCE PLANNING

ASSESSMENT OF CORROSION RESISTANCE OF PROMISING ACCIDENT TOLERANT FUEL CLADDING UNDER REACTOR CONDITIONS