University Of Delaware

NIIMBL RESEARCH, DEVELOPMENT, AND TESTBEDS TO HELP THE NATION PREVENT, PREPARE FOR, AND RESPOND TO CORONAVIRUS

THE NATIONAL INSTITUTE FOR INNOVATION IN MANUFACTURING BIOPHARMACEUTICALS (NIIMBL)

THE NATIONAL INSTITUTE FOR INNOVATION IN MANUFACTURING BIOPHARMACEUTICALS (NIIMBL)

TAS::89 0227::TAS RECOVERY; NEW: RECOVERY ACT - RATIONAL DESIGN OF INNOVATIVE CATALYTIC TECHNOLOGIES FOR BIOMASS DERIVATIVE UTILIZATION -- EFRC; PI

DELAWARE INBRE

DELAWARE - CTR

PURPOSE: PROJECT SUMMARY: MEETING LOCAL RESILIENCE NEEDS THROUGH NATIONAL AND PAN-REGIONAL COLLABORATION PROJECT TITLE: MEETING LOCAL RESILIENCE NEEDS THROUGH NATIONAL AND PAN-REGIONAL COLLABORATION PRIMARY CONTACT: GERHARD F. KUSKA, MARACOOS, UNIVERSITY OF DELAWARE 451 WYOMING AVE NEWARK DE 19716 302-519-1971 KUSKA@MARACOOS.ORG PRIMARY RECIPIENT INSTITUTION: UNIVERSITY OF DELAWARE OTHER INVESTIGATORS/PARTNERS (NAME, AFFILIATED INSTITUTION): CLARISSA ANDERSON, SCRIPPS INSTITUTION OF OCEANOGRAPHY, UNIVERSITY OF CALIFORNIA SAN DIEGO (SCOOS) JENNIFER BOEHME, GREAT LAKES OBSERVING SYSTEM (GLOS) JORGE BRENNER, TEXAS A&M UNIVERSITY, COLLEGE STATION (GCOOS) DEBRA HERNANDEZ, SOUTHEAST COASTAL OCEAN OBSERVING REGIONAL ASSOCIATION (SECOORA) MELISSA IWAMOTO, PACIFIC ISLANDS OCEAN OBSERVING SYSTEM, UNIVERSITY OF HAWAII (PACIOOS) JAKE KRITZER, NORTHEASTERN REGIONAL ASSOCIATION OF COASTAL OCEAN OBSERVING SYSTEMS (NERACOOS) JULIO MORELL, CARICOOS, INC. JAN NEWTON, UNIVERSITY OF WASHINGTON (NANOOS) HENRY RUHL, MONTEREY BAY AQUARIUM RESEARCH INSTITUTE (CENCOOS) SHEYNA WISDOM, ALASKA SEALIFE CENTER (AOOS) KRISTEN YARINCIK, IOOS ASSOCIATION SUMMARY: COASTAL COMMUNITIES AND THE ECOSYSTEMS THAT SUPPORT THEM ARE INCREASINGLY THREATENED BY THE IMPACTS OF CLIMATE CHANGE, INCLUDING RISING TEMPERATURES, OCEAN ACIDIFICATION, SEA LEVEL RISE, COASTAL EROSION AND INUNDATION, HIGHER STORM SURGE, HEAVIER PRECIPITATION, AND STRONGER STORMS. COMMUNITIES ON THE FRONTLINE WHO ARE TRADITIONALLY MARGINALIZED AND UNDERSERVED FOR EXAMPLE LOW-INCOME COMMUNITIES, COMMUNITIES OF COLOR, AND TRIBES AND INDIGENOUS COMMUNITIES ARE DISPROPORTIONATELY AFFECTED BY THE IMPACTS OF CLIMATE AND ECOSYSTEM CHANGE. THIS PROPOSED PROJECT BUILDS ON EXISTING IOOS INFRASTRUCTURE (E.G., OBSERVING PLATFORMS, DATA AND DATA MANAGEMENT SYSTEMS) AND THE DECADES OF EXPERIENCE WITHIN THE IOOS REGIONAL ASSOCIATIONS (RAS) FOR ENGAGING WITH DIVERSE LOCAL COMMUNITIES TO INCREASE DATA AND INFORMATION TOOLS NEEDED BY THOSE COMMUNITIES FOR IMPROVED PLANNING, PREPAREDNESS, AND RESILIENCE. AT THE SAME TIME, THE PROJECT BUILDS NATIONAL CAPACITY FOR UNDERSTANDING ECOSYSTEM AND COASTAL CHANGE AND FOR SERVICE DELIVERY AT SCALES RANGING FROM THE HYPERLOCAL COMMUNITY LEVEL TO NATIONAL MODELS, FORECASTS, ASSESSMENTS, AND TOOLS. THIS PROJECT INTEGRATES THREE INITIATIVES THAT LEVERAGE EXISTING IOOS CAPACITY. THE FIRST TWO ECOSYSTEM CHANGE (ECOCHG) AND WATER LEVEL, WAVES, AND WEBCAMS (WWW) FOCUS ON DATA RELATED TO MONITORING AND UNDERSTANDING EXTREME EVENTS AND CHANGE TO INFORM DECISIONS. THEY INCLUDE GOALS TO: UNDERSTAND AND MEET COMMUNITY NEEDS FOR RELATED OBSERVATIONS; BUILD COMMUNITIES OF PRACTICE TO SHARE AND EVOLVE BEST PRACTICES; DEVELOP COMMON DATA MANAGEMENT PRACTICES AND STANDARDS; AND TO OPTIMIZE PRODUCT DEVELOPMENT AND DELIVERY THROUGH ITERATIVE COMMUNITY ENGAGEMENT. MORE SPECIFICALLY, THE ECOCHG INITIATIVE RE-ENVISIONS ECOSYSTEM CHANGE ASSESSMENT BY BUILDING NATIONAL AND PAN-REGIONAL PARTNERSHIPS TO DELIVER EQUITABLE ECOSYSTEM INFORMATION SERVICES. WORKING IN COLLABORATION, RAS WILL COLLECT AND PROCESS ECOSYSTEM-SCALE INFORMATION THAT ENABLES DECISIONS THAT PROTECT THE ECONOMY, SAFETY, AND LIVELIHOODS OF COMMUNITIES AND THE NATION. THE RESULTING NATIONAL ECOSYSTEM OBSERVING CAPACITY WILL DELIVER REGIONAL INFORMATION THAT IS NEEDED BY FEDERAL, STATE, AND TRIBAL AGENCIES, LOCAL COMMUNITIES, AND INDUSTRIES. THE WWW INITIATIVE WILL BRING OCEAN OBSERVATIONS TO PLACES WHERE INFRASTRUCTURE IS LACKING TO ENABLE WIDER SERVICE TO FRONTLINE COMMUNITIES TO BUILD RESILIENCE TO COASTAL HAZARDS AND INUNDATION. THE RAS WILL WORK WITH COMMUNITIES TO ESTABLISH COORDINATED AND COST-EFFICIENT WWW OBSERVING NETWORKS THAT MEET THEIR LOCAL NEEDS FOR INFORMATION AND DEVELOP SCALABLE GUIDANCE USEFUL FOR NATIONAL IMPLEMENTATION AND INCREASING COVERAGE IN EXISTING FEDERAL NETWORKS OF OBSERVATIONS (E.G., NOAA NATIONAL DATA BUOY CENTER WAVE BUOYS AND NATIONAL WATER LEVEL OBSERVATION NETWORK WATER

TO ADDRESS THE PRESSING FINANCIAL NEED OF STUDENTS DUE TO THE DISRUPTION OF CAMPUS OPERATIONS FROM CORONAVIRUS, AND PURSUANT TO THE AUTHORITY DULY DELEGATED TO THE SECRETARY UNDER THE CARES ACT

TO ADDRESS THE PRESSING FINANCIAL NEED OF STUDENTS DUE TO THE DISRUPTION OF CAMPUS OPERATIONS FROM CORONAVIRUS, AND PURSUANT TO THE AUTHORITY DULY DELEGATED TO THE SECRETARY UNDER THE CARES ACT

MARACOOS (MID-ATLANTIC IOOS): POWERING UNDERSTANDING AND PREDICTION OF THE MID-ATLANTIC OCEAN, COAST, AND ESTUARIES

DISCOVERY OF CHEMICAL PROBES AND THERAPEUTIC LEADS

CENTER OF BIOMEDICAL RESEARCH EXCELLENCE IN CARDIOVASCULAR HEALTH

THE PURPOSE OF THIS MODIFICATION IS TO ADD INCREMENTAL FUNDING IN THE AMOUNT OF 4,563,596.00

DELAWARE EPSCOR: MEETING DELAWARE'S 21ST CENTURY WATER AND ENERGY CHALLENGES THROUGH RESEARCH, EDUCATION, AND INNOVATION

THE BADER CONSORTIUM

RII TRACK 1: WATER SECURITY IN DELAWARE'S CHANGING COASTAL ENVIRONMENT

UNIVERSITY OF DELAWARE MRSEC - CENTER FOR HYBRID, ACTIVE, AND RESPONSIVE MATERIALS (CHARM)

CENTER FOR PLASTICS INNOVATION (CPI)

LARGE-SCALE COPE: COASTAL HAZARDS, EQUITY, ECONOMIC PROSPERITY, AND RESILIENCE (CHEER) -COMMUNITY RESILIENCE REMAINS CHALLENGING TO ACHIEVE IN PRACTICE IN PART DUE TO CONSTRAINTS IMPOSED BY THE PARALLEL, AND SOMETIMES COMPETING, OBJECTIVES OF EQUITY AND ECONOMIC PROSPERITY, PARTICULARLY IN THE CONTEXT OF CLIMATE CHANGE. TO ADDRESS THIS CHALLENGE, THE HUB RESEARCH GOALS ARE TO: (1) IDENTIFY, EXPLAIN, AND QUANTIFY INTERACTIONS AND TRADEOFFS AMONG THE COASTAL COMMUNITY GOALS OF EQUITY, ECONOMIC PROSPERITY, AND RESILIENCE TO HAZARDS; (2) DEVELOP METHODS TO MODEL LONG-TERM HURRICANE HAZARDS THAT ACCOUNT FOR CLIMATE CHANGE AND INTEGRATE MULTIPLE HAZARDS?WIND, RAIN, STORM SURGE, WAVES; AND (3) DEVELOP A COMPUTATIONAL FRAMEWORK TO DESIGN AND EVALUATE POLICY INTERVENTIONS THAT CAN ACHIEVE SUSTAINABLE EQUITY, ECONOMIC PROSPERITY, AND COASTAL RESILIENCE IN THE CONTEXT OF CLIMATE CHANGE. THE NEW DYNAMIC AND SPATIAL COMPUTATIONAL FRAMEWORK WILL CONSIST OF SEVEN INTERACTING MODULES DESCRIBING THE INTERACTIVE DECISION-MAKING OF THREE STAKEHOLDER TYPES--(1) HOUSEHOLDS, (2) INSURERS, AND (3) THREE LEVELS OF GOVERNMENT; AND THE NATURAL, BUILT, AND ECONOMIC ENVIRONMENTS IN WHICH THOSE DECISIONS ARE MADE?(4) HAZARDS, (5) DAMAGE/LOSS, (6) BUILDINGS, AND (7) ECONOMY. THE FRAMEWORK RESULTS WILL INCLUDE: (A) RECOMMENDED GOVERNMENT POLICIES DESIGNED WITH AN AWARENESS OF HOW INSURERS AND HOUSEHOLDS ARE LIKELY TO RESPOND; (B) OUTCOMES FOR EACH STAKEHOLDER TYPE INCLUDING UNCERTAINTY AND HETEROGENEITY WITHIN THEM; AND (C) BASED ON THOSE STAKEHOLDER-SPECIFIC OUTCOMES, ASSESSMENTS OF COMMUNITY EQUITY, ECONOMIC PROSPERITY, AND RESILIENCE OVER TIME. HUB RESEARCH WILL FOCUS ON THREE CASE STUDY AREAS?EASTERN NORTH CAROLINA; PORT ARTHUR, TX; AND HOUSTON, TX. THE COMPUTATIONAL FRAMEWORK WILL SERVE AS THE BASIS OF A DECISION SUPPORT TOOL, WHICH WILL PROPEL IMPLEMENTATION OF COASTAL RESILIENCE FORWARD BY ADDRESSING IMPEDIMENTS THAT INTERACTIONS WITH EQUITY, ECONOMIC PROSPERITY, AND CLIMATE CHANGE CREATE, AND CAPITALIZING ON THE OPPORTUNITIES THEY PRESENT. CLOSE COLLABORATION WITH PRACTITIONER AND COMMUNITY PARTNERS WILL ENSURE THE DECISION TOOL IS USEFUL TO PRACTITIONERS AND ADVANCES THE INTERESTS OF COMMUNITIES. JUST AS THE REGIONAL LOSS MODELING FRAMEWORK PROVIDED A STRUCTURE THAT HAS GUIDED RESEARCH FOR DECADES, THE HUB?S FRAMEWORK CAN FACILITATE FUTURE INTERDISCIPLINARY RESEARCH THAT MAKES LOSS MODELING DYNAMIC AND INCLUDES A RICH REPRESENTATION OF DECISION-MAKING EMBEDDED IN THE RELEVANT SOCIAL AND ECONOMIC CONTEXT. MORE SPECIFIC DISCIPLINARY ADVANCES INCLUDE UNDERSTANDING HOW WIND, RAIN, INLAND AND COASTAL FLOODING HAZARDS DYNAMICALLY INTERACT, INCLUDING POTENTIAL IMPACTS UNDER FUTURE CLIMATE SCENARIOS; DEVELOPING AN AUTOMATED, SCALABLE METHOD FOR CREATING A HIGH RESOLUTION, DETAILED INVENTORY OF RESIDENTIAL BUILDINGS; ENHANCING UNDERSTANDING OF HURRICANES? EFFECTS ON REGIONAL ECONOMIES? EVOLUTION; MODELING INTERACTIONS AMONG LEVELS OF GOVERNMENT; OPERATIONALIZING MULTIPLE CONCEPTS OF EQUITY AND THEIR IMPLICATIONS; AND EXPANDING UNDERSTANDING OF RENTERS? AND MOBILE HOME RESIDENTS? EXPERIENCES WITH RISK AND RISK MANAGEMENT. THE HUB WILL IMPLEMENT A COMPREHENSIVE, RESEARCH-BASED MENTORING PROGRAM, INCLUDING QUICK RESPONSE FIELDWORK TRAINING, AND WILL BROADEN PARTICIPATION OF STUDENTS THROUGH PARTNERSHIPS WITH THE MCNAIR SCHOLARS PROGRAM AND BILL ANDERSON FUND, NATIONAL ORGANIZATIONS SUPPORTING GRADUATE STUDENTS FROM UNDERREPRESENTED GROUPS. THE HUB WILL ENGAGE OTHER RESEARCHERS AND THE PUBLIC THROUGH DEVELOPMENT OF DISCIPLINE PRIMERS AND DRC IT! MODULES; WORKSHOPS WITHIN THE CASE STUDY COMMUNITIES; AND THE HURRICON II CONFERENCE. PARTNERSHIPS WITH SIMCENTER, DESIGNSAFE-CI, AND THE DISASTER RESEARCH CENTER WILL HELP ENSURE SUSTAINABILITY. THIS PROJECT IS JOINTLY FUNDED BY THE COASTLINES & PEOPLE (COPE) PROGRAM AND THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

IDEA NETWORK OF BIOMEDICAL RESEARCH EXCELLENCE

DELAWARE EPSCOR RESEARCH IMPROVEMENT (RII-2) PROPOSAL: BUILDING RESEARCH AND EDUCATION INFRASTRUCTURE TO ENHANCE ENVIRONMENTAL SCIENCE AND ITS APPLIC

COMPOSITES RESEARCH, ENGINEERING AND ADVANCED TECHNOLOGY CREATE

CENTER FOR HANDS-ON TRAINING AND LEARNING ENVIRONMENT FOR THE NEXT GENERATION RAILROAD TECHNICAL WORKFORCE HTL

DELAWARE CENTER FOR MUSCULOSKELETAL RESEARCH - PROJECT SUMMARY/ABSTRACT THE MUSCULOSKELETAL SYSTEM HAS BOTH MECHANICAL AND BIOLOGICAL FUNCTIONS—IT GENERATES, TRANSMITS, AND SUPPORTS FORCES, AND IT REGULATES ORGAN-LEVEL HOMEOSTASIS AND WHOLE-BODY METABOLISM. THE MECHANICS AND BIOLOGY OF THE MUSCULOSKELETAL SYSTEM ARE INEXTRICABLY INTERTWINED AND LONG-RANGING, WHERE MECHANICAL CUES, MOLECULAR SIGNALS, AND CELL INTERACTIONS AFFECT EACH OTHER ACROSS MULTIPLE SCALES, FROM THE BODY, TO ORGAN, TISSUE, CELL, AND MOLECULE LEVELS. PROGRESS IN MUSCULOSKELETAL RESEARCH DEPENDS ON ADDRESSING THE MECHANICS AND BIOLOGY OF ADJACENT ORGANS, AND EVALUATING THE EFFECTS OF INJURY AS WELL AS AGING. IDENTIFYING THE MECHANISMS UNDERLYING MUSCULOSKELETAL HEALTH AND MUSCULOSKELETAL DISORDERS (E.G., OSTEOARTHRITIS, OSTEOPOROSIS, MUSCLE WASTING, POST-TRAUMATIC REPAIR, DEGENERATION) THEREFORE REQUIRES A RESEARCH PARADIGM THAT ADDRESSES THE SYNERGIES WITHIN THE MUSCULOSKELETAL SYSTEM AND COMBINES BOTH MECHANICAL AND BIOLOGICAL APPROACHES ACROSS MULTIPLE SCALES. THE DELAWARE CENTER FOR MUSCULOSKELETAL RESEARCH (DCMR) WILL SUPPORT BASIC AND PRECLINICAL RESEARCH ON THE CENTRAL THEME OF MUSCULOSKELETAL HEALTH—FROM THE LEVEL OF THE ENTIRE BODY TO THE ACTIONS OF KEY CELLS AND MOLECULES—WITH EMPHASIS ON UNDERSTANDING THE MECHANISMS BY WHICH PHYSICAL AND BIOLOGICAL CUES INFLUENCE TISSUE STRUCTURE AND NORMAL FUNCTION AND DYSFUNCTION, AND IDENTIFYING POTENTIAL THERAPEUTIC INTERVENTIONS. THE PROPOSED DCMR WILL: AIM 1: ACCELERATE FUNDAMENTAL MUSCULOSKELETAL RESEARCH BY SUPPORTING SYNERGISTIC AND MULTIDISCIPLINARY RESEARCH PROJECTS. AIM 2: GALVANIZE CAPABILITIES FOR MUSCULOSKELETAL RESEARCH BY ESTABLISHING A MULTISCALE ASSESSMENTS RESEARCH CORE. AIM 3: AMPLIFY THE IMPACT OF MUSCULOSKELETAL RESEARCH THROUGH FACULTY MENTORING, EXPANSION, AND RETENTION. COMPLETION OF THIS 5-YEAR PHASE I COBRE WILL BUILD CROSS-CUTTING AND SYNERGISTIC RESEARCH COLLABORATIONS ACROSS MULTI-SCALE AND MULTIDISCIPLINARY RESEARCH PROJECTS AND ESTABLISH A STATE-OF-THE-ART RESEARCH CORE. THE DCMR, WHICH WILL FOCUS ON FUNDAMENTAL DISCOVERY AND PRECLINICAL RESEARCH, WILL COMPLEMENT THE OUTSTANDING TRANSLATIONAL AND CLINICAL MUSCULOSKELETAL RESEARCH PROGRAMS AT DELAWARE, CREATING A COMPREHENSIVE BASIC-TO- CLINICAL RESEARCH PIPELINE AT UD. THROUGH FOSTERING CROSS-CUTTING AND CONVERGENT RESEARCH PARTNERSHIPS, THE DCMR AIMS TO SUBSTANTIALLY REDUCE THE BURDEN OF MUSCULOSKELETAL DISORDERS AND IMPROVE MUSCULOSKELETAL HEALTH.

EARLY HEAD START

THIS COOPERATIVE AGREEMENT SHALL BE PERFORMED IN ACCORDANCE WITH THE STATEMENT OF WORK (SOW) ENTITLED, "LOW-COST COMPOSITE PARTS - TAILORABLE FEEDSTOC

DIRECTOR

HEAD START

MID-SCALE RI:1 (M1:IP): A WORLD-CLASS NEUTRON SPIN ECHO SPECTROMETER FOR THE NATION: UD-NIST-UMD CONSORTIUM

COMPOSITE APPLIED RESEARCH AND TECHNOLOGY

COBRE FOR WOMEN IN SCIENCE & ENGINEERING ON OSTEOARTHRITIS

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - THIS PROJECT WILL CONTINUE A DESIGN-BUILD CONSTRUCTION EFFORT FOR A CURRENT GOOD MANUFACTURING PRACTICES (CGMP) FACILITY TO SUPPORT BIOPHARMACEUTICAL INNOVATION TO BE LOCATED ON THE UNIVERSITY OF DELAWARE’S (UD’S) SCIENCE, TECHNOLOGY, AND ADVANCED RESEARCH (STAR) CAMPUS. THE ENVISIONED SECURING AMERICAN BIOMANUFACTURING RESEARCH AND EDUCATION (SABRE) CENTER WILL PROVIDE INFRASTRUCTURE TO SUPPORT DEVELOPMENT AND MANUFACTURING OF CUTTING-EDGE SUCH AS GENE THERAPIES, MRNA VACCINES, AND OTHER BIOPHARMACEUTICALS.

NATIONAL CENTER FOR SPECIAL RESEARCH (NCSER)

BUILDING COASTAL COMMUNITY RESILIENCE WITH NATURE-BASED SHORELINE SOLUTIONS

EARLY HEAD START

NIIMBL RESPONDS TO THE COVID-19 PANDEMIC #1

SPECIALIZED SERVICES FOR HIGH-RISK BIRTH PARENTS

CENTER FOR NEUTRON SCIENCE AT THE UNIVERSITY OF DELAWARE: SOLVING GRAND CHALLENGE PROBLEMS WITH NEUTRON SCATTERING

PRO: A PROTEIN ONTOLOGY IN OPEN BIOMEDICAL ONTOLOGIES

MCKINLY LABORATORY ANIMAL FACILITY RENOVATION AND EXPAN*

CA NEW START FOR UNIVERSITY OF DELAWARE - CLEAN HYDROGEN PARTNERSHIP

ADVANCED METROLOGY FOR NANOMATERIALS CHARACTERIZATION: COMPLEX FLUIDS AND BIOMATERIALS UNDER APPLIED FIELDS, PROTEIN AND POLYELECTROLYTE STRUCTURE-FU

MOLECULAR DESIGN OF ADVANCED BIOMATERIALS

MULTIFUNCTION ENABLED ACCESS THROUGH NETWORKED SENSORS (MEANS)

MULTIFUNCTIONAL COMPOSITE MATERIALS AND STRUCTURES FOR LIGHT WEIGHT VEHICLE PROTECTION

ANTICIPATING THREATS TO NATURAL SYSTEMS ACTIONS

PURPOSE: THE PURPOSE OF THIS PROJECT IS TO PROCURE BIOPHARMACEUTICAL MANUFACTURING EQUIPMENT AT THE PILOT / CLINICAL SCALE AT THE NATIONAL INSTITUTE FOR INNOVATION IN MANUFACTURING BIOPHARMACEUTICALS (NIIMBL). THIS EQUIPMENT WILL SERVE AS A TESTBED THAT WILL BE USED BY PARTNERS AND SCIENTISTS FROM ACROSS THE NIIMBL ECOSYSTEM TO BENCHMARK CURRENT AND FUTURE BIOPHARMACEUTICAL MANUFACTURING INNOVATIONS. IT WILL ALSO BE AVAILABLE TO SUPPORT TRAINING OF THE WORKFORCE. THIS TESTBED IS ENVISIONED TO EVENTUALLY BE HOUSED IN THE PLANNED SECURING AMERICAN BIOMANUFACTURING RESEARCH AND EDUCATION (SABRE) CENTER. ACTIVITIES TO BE PERFORMED: PHASE 1 (MONTHS 0-9): FINALIZE DETAILS, SPECIFICATIONS, AND RECEIVE NECESSARY QUOTATIONS FOR EQUIPMENT. IN THIS PHASE, THE TEAM WILL WORK WITH SUBJECT MATTER EXPERTS FROM NIIMBL AS WELL AS IPS, THE CONTRACTED DESIGN TEAM, TO FINALIZE SPECIFICATIONS OF EQUIPMENT TO BE PROCURED AS PART OF THIS TESTBED. WHILE THE DETAILED SPECIFICATIONS NEED TO BE WRITTEN UP IN CONCERT WITH THE FACILITY DESIGN, THE HIGH-LEVEL SPECIFICATION IS FOR COLD STORAGE (CONTROLLED RATE FREEZERS), SEED ROCKING BIOREACTORS, TWO SINGLE USE PILOT SCALE BIOREACTORS, TANGENTIAL FLOW FILTRATION SYSTEMS, CHROMATOGRAPHY SYSTEMS, AND WATER FOR INJECTION SYSTEMS. PHASE 2 (MONTHS 9-12): PROCURE EQUIPMENT INCLUDING ENSURE FACTORY ACCEPTANCE TESTING (AS APPROPRIATE), RECEIPT AND PROPER INSTALLATION, AND SITE ACCEPTANCE TESTING AND COMMISSIONING. IN THIS PHASE, UNIVERSITY OF DELAWARE OR THE CONSTRUCTION MANAGEMENT FIRM AS A CONTRACTOR, WILL GO THROUGH PROCUREMENT ACTIONS TO PLACE PURCHASE ORDERS FOR EQUIPMENT, FOLLOWING APPROPRIATE POLICIES AND APPLICABLE FEDERAL REGULATIONS AND TERMS AND CONDITIONS, AND WORK WITH VENDORS TO MONITOR LEAD TIMES, PURCHASE MISCELLANEOUS NECESSARY SUPPLIES, PERFORM ANY NECESSARY FACILITY UPDATES REQUIRED TO OPERATE THE EQUIPMENT (E.G., RUN EMERGENCY BACKUP POWER LINES TO APPROPRIATE SPACES), RECEIVE EQUIPMENT, AND ENSURE PROPER INSTALLATION AND QUALIFICATION OF THE EQUIPMENT. EXPECTED OUTCOMES: ONCE INSTALLED, THIS EQUIPMENT WILL BE USED BOTH FOR WORKFORCE DEVELOPMENT TRAINING ACTIVITIES WHICH WILL BENEFIT THE BROAD ECOSYSTEM BY ENSURING A POOL OF CAPABLE WORKERS, AS WELL AS BE USED TO DO PILOT SCALE MANUFACTURING WITH AN INTENSIFIED PROCESSING APPROACH - HELPING ACCELERATE THE INDUSTRY'S PUSH IN THIS DIRECTION. THUS, ONE IMPORTANT IMPACT OF THIS TESTBED IS TO ENHANCE THE IMPACT OF THE NIIMBL PROCESS INTENSIFICATION TESTBED BY ALLOWING LARGER SCALE STUDIES AND TESTING OF NEW INNOVATIONS, AS WELL AS TO SUPPORT WORKFORCE DEVELOPMENT. DATA THAT WILL BE COLLECTED CAN BE USED TO INFORM SHARED MODELS FOR PROCESS DEVELOPMENT AND MANUFACTURING AND MATERIALS THAT ARE GENERATED CAN BE DISTRIBUTED AND SHARED TO SUPPORT ANALYTICAL STUDIES WITHIN NIIMBL. THE IMPACT OF THIS PROJECT WILL BE EVALUATED AND MEASURED BY QUANTIFYING: 1) THE NUMBER OF BATCHES PRODUCED USING THE EQUIPMENT SPECIFIED AS PART OF THIS PROJECT. 2) THE NUMBER OF INDIVIDUALS THAT ACCESS THE EQUIPMENT THROUGH NIIMBL AND NIIMBL-RELATED ACTIVITIES. 3) THE NUMBER OF TRAININGS OFFERED ASSOCIATED WITH THE EQUIPMENT IN THE PLANNED SABRE CENTER. INTENDED BENEFICIARIES: BENEFICIARIES WILL BE PARTNERS AND SCIENTISTS FROM ACROSS THE NIIMBL ECOSYSTEM TO BENCHMARK CURRENT AND FUTURE BIOPHARMACEUTICAL MANUFACTURING INNOVATIONS. IT WILL ALSO SUPPORT TRAINING OF THE WORKFORCE. SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

SMALL ANGLE NEUTRON SCATTERING ON POLYMERS AND COMPLEX FLUIDS

SYNTHETIC METHYLOTROPHY TO LIQUID FUEL

MEMBRANE SKELETON REGULATION OF CELL SHAPE AND INTERACTIONS IN LENS DEVELOPMENT

THE INFLUENCE OF CAPSULE COMPOSITION ON LENS BIOLOGY

SHIP OPERATIONS- R/V HUGH R. SHARP CY 18-22

RII TRACK-2 FEC: G2P IN VOM: AN EXPERIMENTAL AND ANALYTICAL FRAMEWORK FOR GENOME TO PHENOME CONNECTIONS IN VIRUSES OF MICROBES

CHRONIC LOW BACK PAIN IN OLDER ADULTS: THE ROLE OF CO-EXISTING HIP IMPAIRMENTS

DELAWARE SEA GRANT 2018-2022 OMNIBUS

ART: TRANSLATING ENGINEERING DRIVEN HEALTH INITIATIVES FROM IDEA TO IMPACT -DESPITE THE HIGH LEVEL OF FUNDAMENTAL RESEARCH PRODUCTIVITY EXHIBITED AT THE UNIVERSITY OF DELAWARE, THE LEVEL OF TRANSLATIONAL RESEARCH ACTIVITY REMAINS RELATIVELY LOW. THIS ACCELERATING RESEARCH TRANSLATION (ART) PROJECT INTRODUCES AN ACCELERATED INNOVATION ECOSYSTEM WHERE UNMET NEEDS AND USE-DEFINED GAPS DERIVED FROM RELEVANT STAKEHOLDERS AND CORPORATE PARTNERS PROVIDE INSPIRATION. A CLUSTER OF INNOVATORS IN THE ENGINEERING DRIVEN HEALTH SPACE AND OTHER APPLIED RESEARCH DOMAINS WILL CONVERT USE-INSPIRED RESEARCH INTO ENABLING TECHNOLOGY WITH WELL-DEFINED APPLICATION RESULTING IN IMPACTFUL TECHNOLOGY TRANSLATION. ENTREPRENEURIALLY MINDED INDIVIDUALS FROM ACROSS CAMPUS WILL BENEFIT FROM TRAINING ACTIVITIES FOR EDUCATION AND WORKFORCE DEVELOPMENT. IT IS CRITICALLY IMPORTANT THAT AS AN ECONOMIC ENGINE FOR DELAWARE STATE AND REGION, THE UNIVERSITY OF DELAWARE (UD) LEVERAGES ITS WORLD-CLASS TALENT FOR PRODUCING NOVEL TECHNOLOGIES WITH SOCIETAL BENEFIT FOR CITIZENS AND THE NATION. THIS PROJECT WILL: (1) STRENGTHEN INSTITUTIONAL CAPACITY FOR USE-INSPIRED AND TRANSLATIONAL RESEARCH AT UD, (2) CONTINUALLY EDUCATE NEW COHORTS OF TRAINEES IN TRANSLATIONAL RESEARCH TO BECOME ENTREPRENEURS OR SEEK TRANSLATIONAL RESEARCH-ORIENTED CAREERS IN PUBLIC/PRIVATE SECTORS, AND (3) CREATE AND NURTURE A SET OF ART AMBASSADORS WHO ARE CHANGE AGENTS IN A CULTURE OF INNOVATION. A SERIES OF CAPACITY-BUILDING ACTIVITIES INVOLVING THE CREATION OF CRITICAL POSITIONS IN TECH TRANSFER AND CORPORATE ENGAGEMENT, INCLUSION OF PTIE.ORG-INSPIRED INCENTIVES IN PROMOTION AND TENURE POLICIES, AND STREAMLINED PROCESSES TO PROMOTE CORPORATE PARTNERSHIP WILL BE INTEGRATED WITH UD OFFICE OF ECONOMIC INNOVATION AND PARTNERSHIPS OPERATIONS. TRAINING PROGRAMS DESCRIBING THE INTERNAL MECHANISMS AND SUPPORT AVAILABLE TO INNOVATORS WHO ARE INTERESTED IN EXPLORING THE COMMERCIALIZATION POTENTIAL OF THEIR INVENTIONS WILL BE ROLLED OUT IN PARTNERSHIP WITH THE HORN ENTREPRENEURSHIP PROGRAM TO A DIVERSE SET OF UNDERGRADUATE AND GRADUATE STUDENTS, POSTDOCTORAL RESEARCHERS, STAFF, FACULTY, AND VISITING SCHOLARS ACROSS DISCIPLINES. THIS ACCELERATED MODEL OF RESEARCH TRANSLATION WILL BE DEMONSTRATED WITH AT LEAST TWO NEW SEED TRANSLATIONAL RESEARCH PROJECTS PER YEAR, WITH THE INSTITUTE FOR ENGINEERING DRIVEN HEALTH SERVING AS THE INITIAL TEST PLATFORM. ADDITIONAL HUBS OF ENTREPRENEURIAL ACTIVITY IN AGRICULTURE, SOCIAL SCIENCES, OR OTHER DOMAINS WILL BE IDENTIFIED AND INVITED TO PARTICIPATE IN ALL ART PROGRAMS. REGULAR INTERACTIONS WITH MENTORS AT PRINCETON UNIVERSITY TO SHARE EXPERTISE IN TRANSLATIONAL ACTIVITIES WILL ALSO ENABLE RICH CONVERSATIONS ABOUT REGIONAL INNOVATION ENGINES. IN THE SHORT TERM, ART ACTIVITIES WILL DRIVE INNOVATION AND TRANSLATION IN THE BIOMEDICAL ARENA, WHILE IN THE LONG TERM THE INFRASTRUCTURE DEVELOPED THROUGH THIS PROCESS WILL ACCELERATE ENTREPRENEURSHIP AND COMMERCIALIZATION ACTIVITIES ACROSS MULTIPLE UNITS AT UD. BEYOND THE QUANTITATIVE OUTCOMES, THIS PROJECT WILL HAVE A PROFOUND IMPACT ON THE CAMPUS CULTURE BY ENCOURAGING AN ENTREPRENEURIAL MINDSET AND FOSTERING INNOVATION EXCELLENCE. THIS TYPE OF ENVIRONMENT WILL ATTRACT LIKE-MINDED STUDENTS AND FACULTY DESTINED TO IMPROVE THE HUMAN CONDITION BY BRINGING INNOVATIONS TO LIFE. THIS PROJECT IS JOINTLY FUNDED BY THE TECHNOLOGY, INNOVATION, AND PARTNERSHIPS (TIP) DIRECTORATE AND THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR) AND THE LOUIS STOKES ALLIANCES FOR MINORITY PARTICIPATION (LSAMP) PROGRAM WITHIN THE DIVISION OF EQUITY FOR EXCELLENCE IN STEM (EES/EDU). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

SHIP OPERATIONS- R/V HUGH R. SHARP

DELAWARE SEA GRANT 2014-2017 OMNIBUS

RII TRACK-2 FEC: NEURAL NETWORKS UNDERLYING THE INTEGRATION OF KNOWLEDGE AND PERCEPTION

URBAN AIR MOBILITY (UAM) A SAFE AND EFFICIENT AIR TRANSPORTATION SYSTEM FOR ON-DEMAND MOBILITY (ODM) FROM SMALL PACKAGE DELIVERY TO AIR TAXIS HAS ARRIVED AS THE NEXT FRONTIER IN AIR TRANSPORTATION. MARKET STUDIES HAVE ESTABLISHED ECONOMIC FACTORS

UNDERSTANDING THE RICE EPIGENOME: FROM GENES TO GENOMES

DELAWARE SEA GRANT 2010 OMNIBUS

MOLECULAR DESIGN OF ADVANCED BIOMATERIALS

SHIP OPERATIONS

ASSESSING REHABILITATION OUTCOMES AFTER SEVERE NEUROMUSCULOSKELETAL INJURY DEVELOPMENT OF PATIENT REPORTED OUTCOMES ASSESSMENT INSTRUMENTS

CAPPING ACTIN GROWTH IN ERYTHROID AND NONERYTHROID CELLS

OSTEOARTHRITIS: PREVENTION AND TREATMENT

A HYDROGEL-BASED CELLULAR MODEL OF THE HUMAN VOCAL FOLD

LOW COST BACK CONTACT HETEROJUNCTION SOLAR CELLS ON THIN C-SI WAFERS: INTEGRATING LASER AND THIN FILM PROCESSING FOR IMPROVED MANUFACTURABILITY

PURPOSE: THE PURPOSE OF THIS COOPERATIVE AGREEMENT IS TO ADVANCE NEUTRON SCATTERING METROLOGY FOR RESEARCH IN SOFT MATTER SCIENCE AND ENGINEERING.ACTIVITIES TO BE PERFORMED: SUPPORT AND DEVELOP ADVANCED NEUTRON METROLOGY INSTRUMENTATION AND METHODS AND ASSIST THE BROADER U.S. NEUTRON RESEARCH COMMUNITY IN ACADEMIA, INDUSTRY, AND GOVERNMENT SERVICE. DISSEMINATE DATA AND RESEARCH RESULTS; CONTRIBUTE TO THE NEXT GENERATION OF RESEARCHERS; PROVIDE RESEARCH ASSISTANCE TO NCNR FACILITY USERS; PROVIDE SUPPORT FOR PROJECT OBJECTIVES BY COLLABORATING WITH NIST SCIENTISTS. ENHANCE THE TRAINING, EDUCATION, AND OUTREACH ACTIVITIES THROUGH DIRECT INTERACTION WITH U.S. NEUTRON RESEARCHERS. PROJECTS RANGE FROM ENERGY RESEARCH (I.E., CHARACTERIZATION OF ION TRANSPORT TO SUPPORT DEVELOPMENT HIGH-PERFORMANCE SOLID POLYMER ELECTROLYTES AND ZEOLITE-BASED MATERIALS FOR HYDROGEN STORAGE) TO BIOPHARMACEUTICAL STABILITY.EXPECTED OUTCOMES: IT IS ANTICIPATED THAT THE WORK OUTLINED IN THIS PROPOSAL WILL PRODUCE SIGNIFICANT SCIENTIFIC ADVANCEMENTS AS WELL AS IMPROVEMENTS TO THE NIST FACILITY BY DEVELOPING, DESIGNING, AND BUILDING NEW INSTRUMENTS; DEVELOPING NEW AND IMPROVED SOFTWARE INTERFACES FOR EXISTING AND NEW INSTRUMENTS; AND SUPPORTING RESEARCH ACTIVITIES AT THE NCNR BY ADVANCING THE USE OF NEUTRONS BY SCIENTISTS M ACADEMIA AND INDUSTRY.INTENDED BENEFICIARIES: U.S. SCIENTIFIC COMMUNITY AND THE GENERAL PUBLIC.SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

POST TRANSCRIPTIONAL CONTROL OF GENE EXPRESSION IN THE LENS (LENS GENE EXPRESSION

2019-2023 OPERATIONS, MAINTENANCE, REPAIR, AND UPGRADE OF UNIV OF DELAWARE OCEANOGRAPHIC RESEARCH ASSETS

FROM FIRST PRINCIPLES DESIGN TO REALIZATION OF BIMETALLIC CATALYSTS FOR ENHANCED SELECTIVITY

EXPANDS CLIMATE-SMART LEGUMES, CITRUS, VEG. AND INDUSTRIAL HEMP MARKETS IN DE, PA, VA, MD, NJ, SC, GA, FL, AL, CA ,OR SUPPORTING FARMERS WITH CLIMATE-SMART PRACTICE IMPLEMENTATION AND MONITORING.

PIRE: BIO-INSPIRED MATERIALS AND SYSTEMS

PURPOSE: MARACOOS ACTIVITIES WILL STRENGTHEN THE REGIONAL ASSOCIATION BY DIRECTLY CONTRIBUTING TO MARACOOS STRATEGIC PLAN GOALS OF: 1) AN EXPANDED AND DIVERSIFIED STAKEHOLDER COMMUNITY; 2) AN INCREASED UNDERSTANDING OF STAKEHOLDER NEEDS; 3) MORE DEPENDABLE, INNOVATIVE, AND EXPANDED DATA COLLECTION AND CURATION; 4) TAILORED DATA PRODUCTS AND SOLUTIONS BASED ON STAKEHOLDER NEEDS; AND 5) A MORE DIVERSE, COLLABORATIVE, INNOVATIVE AND OVERALL HEALTHIER ORGANIZATION.

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - THIS PROJECT WILL CONTINUE A DESIGN AND BUILD CONSTRUCTION EFFORT FOR A CURRENT GOOD MANUFACTURING PRACTICES (CGMP) CAPABLE FACILITY TO SUPPORT BIOPHARMACEUTICAL INNOVATION TO BE LOCATED ON THE UNIVERSITY OF DELAWARE SCIENCE, TECHNOLOGY, AND ADVANCED RESEARCH (STAR) CAMPUS. THE ENVISIONED SECURING AMERICAN BIOMANUFACTURING RESEARCH AND EDUCATION (SABRE) CENTER WILL PROVIDE INFRASTRUCTURE TO SUPPORT DEVELOPMENT AND MANUFACTURING OF CUTTING-EDGE BIOPHARMACEUTICALS SUCH AS GENE THERAPIES, MONOCLONAL ANTIBODIES, AND OTHER RELATED BIOPHARMACEUTICALS.

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - THIS PROJECT WILL INITIATE A DESIGN-BUILD CONSTRUCTION EFFORT FOR A CURRENT GOOD MANUFACTURING PRACTICES (CGMP) FACILITY TO SUPPORT BIOPHARMACEUTICAL INNOVATION TO BE LOCATED ON THE UNIVERSITY OF DELAWARE'S (UD'S) SCIENCE, TECHNOLOGY, AND ADVANCED RESEARCH (STAR) CAMPUS. THE ENVISIONED SECURING AMERICAN BIOMANUFACTURING RESEARCH AND EDUCATION (SABRE) CENTER WILL PROVIDE INFRASTRUCTURE TO SUPPORT DEVELOPMENT AND MANUFACTURING OF CUTTING-EDGE SUCH AS GENE THERAPIES, MRNA VACCINES, AND OTHER BIOPHARMACEUTICALS.

PURPOSE: PROVIDE EQUIPMENT FOR NIIMBL GENE VECTOR PRODUCTION AT THE UNIVERSITY OF DELAWARE (UD). THE EQUIPMENT WILL FACILITATE PROCESS IMPROVEMENTS, WORKFORCE DEVELOPMENT, AND THE TESTING AND DEMONSTRATION OF BIOPHARMACEUTICAL INNOVATIONS. THIS FACILITY WILL LEVERAGE THE KNOWLEDGE AND EXPERIENCE OF THE NIIMBL, A PUBLIC-PRIVATE PARTNERSHIP FOCUSED ON THE ACCELERATION OF THE BIOPHARMACEUTICAL INNOVATION. ACTIVITIES TO BE PERFORMED: THIS PROJECT WILL PROCURE, INSTALL, AND VALIDATE EQUIPMENT AT UD FOR GENE VECTOR PRODUCTION THAT WILL SERVE AS A SCALE-DOWN MODEL OF THE INDUSTRIAL SCALE PROCESSES. PHASE 1 WILL INCLUDE FINALIZING DETAILS, SPECIFICATIONS, AND RECEIVE NECESSARY QUOTATIONS FOR EQUIPMENT. IN PHASE 2, THEY WILL PROCURE AND INSTALL EQUIPMENT, AND PERFORM SITE ACCEPTANCE TESTING. EXPECTED OUTCOMES: THE UD GENE VECTOR PRODUCTION TESTBED WILL ALLOW SMALLER SCALE, MORE RAPID, AND MORE AFFORDABLE BIOPHARMACEUTICAL EXPERIMENTS TO BE PERFORMED. THE TESTBED WILL ENABLE WORKFORCE DEVELOPMENT AND TRAINING, DATA TO BE COLLECTED AND USED IN PROCESS MODELS BEING DEVELOPED AND PRODUCE NEW MATERIALS THAT CAN BE SHARED WITH THE BIOPHARMACEUTICAL MANUFACTURING INNOVATION COMMUNITY. INTENDED BENEFICIARIES:1. TO NIST: THE WORK PLANS ALIGN WITH NIST'S MANUFACTURING MISSION SPACE FOR BOTH ADVANCED MANUFACTURING TECHNOLOGY AND SUPPLY CHAIN SECURITY. NIST STAFF CAN LEVERAGE THIS PROJECT TO FURTHER THE IMPACT OF OUR TECHNICAL EXPERTISE IN BIOMANUFACTURING FOR GENE THERAPIES. THE PROJECT ALSO LEVERAGES NIST'S INVESTMENT IN NIIMBL. 2. TO AWARDEE: THE UNIVERSITY OF DELAWARE, AS THE LEAD OF THE NIIMBL CONSORTIUM, WILL BE ABLE TO ESTABLISH A MORE COST-EFFICIENT CAPABILITY TO DO SMALL SCALE PROCESS-DEVELOPMENT WORK ON INDUSTRIALLY RELEVANT EQUIPMENT FOR GENE THERAPY MANUFACTURING INNOVATION. 3. TO THE NATION: THE IMPORTANCE OF AN AGILE DOMESTIC CAPACITY FOR PRODUCTION OF BIOMANUFACTURED GENE THERAPIES IS CRITICAL FOR ADVANCING THE NATION'S CAPABILITIES TO SUPPORT BOTH DOMESTIC COMPETITIVENESS AND PUBLIC HEALTH NEEDS. THE UNIVERSITY OF DELAWARE'S LEADERSHIP OF THE NIIMBL PARTNERSHIP SUPPORTS THE COLLABORATIVE DEVELOPMENT OF THE NEXT GENERATION PROCESSES FOR MANUFACTURING THESE CRITICAL PRODUCTS. THIS FUNDING WILL ENABLE NIIMBL TO PROVIDE AN OPEN COLLABORATION RESOURCE FOR THE US BIOECONOMY THAT WILL AID IN DEVELOPING NEW TECHNOLOGIES TO SUPPORT FASTER TO MARKET, HIGHER QUALITY AND EXTENDED SUPPLY AND AVAILABILITY OF CELLULAR AND GENE-THERAPY PRODUCTS. SUBRECIPIENT ACTIVITIES:NO SUBRECIPIENT ACTIVITIES WILL BE INVOLVED WITH THIS GRANT.

EDUCATION RESEARCH AND DEVELOPMENT CENTERS

WIND TURBINE MODEL AND PILOT POJECT FOR ALTERNATIVE ENERGY

PROGRAM ABSTRACT PURPOSE: THE NATIONAL SEA GRANT COLLEGE PROGRAM WAS ESTABLISHED BY THE U.S. CONGRESS IN 1966 (AMENDED IN 2008, PUBLIC LAW 110-394) TO BE A HIGHLY LEVERAGED FEDERAL AND STATE PARTNERSHIP TO HARNESS THE INTELLECTUAL CAPACITY OF THE NATION'S UNIVERSITIES AND RESEARCH INSTITUTIONS TO SOLVE PROBLEMS AND GENERATE OPPORTUNITIES IN COASTAL COMMUNITIES. FOR OVER 50 YEARS, THE NATIONAL SEA GRANT COLLEGE PROGRAM HAS SUPPORTED COASTAL AND GREAT LAKES COMMUNITIES THROUGH RESEARCH, EXTENSION, AND EDUCATION. SEA GRANT'S MISSION IS TO ENHANCE THE PRACTICAL USE AND CONSERVATION OF COASTAL, MARINE AND GREAT LAKES RESOURCES IN ORDER TO CREATE A SUSTAINABLE ECONOMY AND ENVIRONMENT. THIS GRANT IS THE VEHICLE THROUGH WHICH DELAWARE SEA GRANT LAYS OUT ITS PLAN TO IMPLEMENT THE GOALS LAID OUT IN IN THEIR FY2024-27 STRATEGIC PLAN, WHICH CAN BE FOUND AT: HTTPS://SEAGRANT.NOAA.GOV/INSIDESEAGRANT/PLANNING IN ADDITION TO REQUIRED GRANT PROGRESS REPORTING, THE RECIPIENT WILL REPORT DEFINED MEASURES AND METRICS AS WELL AS SUCCESS STORIES ANNUALLY AND WILL BE EVALUATED ON PERFORMANCE DURING A SITE REVIEW EXPECTED IN 2028 OR 2029. ACTIVITIES TO BE PERFORMED: EACH UNIVERSITY-BASED SEA GRANT PROGRAM CONTRIBUTES TO THE NATIONAL FOCUS AREAS AND GOALS, AND DELAWARE SEA GRANT IS NO DIFFERENT, ALIGNING THEIR FOCUS AREAS WITH THE NATIONAL SEA GRANT STRATEGIC PLAN'S FOCUS AREAS OF: HEALTHY COASTAL ECOSYSTEMS, SUSTAINABLE FISHERIES AND AQUACULTURE, RESILIENT COMMUNITIES AND ECONOMIES, AND ENVIRONMENTAL LITERACY AND WORKFORCE DEVELOPMENT. ACTIVITIES WITHIN EACH OF THESE FOCUS AREAS INCLUDE RESEARCH, EXTENSION AND EDUCATIONAL PROJECTS THAT AIM TO FURTHER THE NATIONAL SEA GRANT COLLEGE PROGRAM'S STATED MISSION. EXPECTED OUTCOMES: NOAA PROVIDES FUNDING TO SEA GRANT INSTITUTIONS TO INCREASE THE UNDERSTANDING, ASSESSMENT, DEVELOPMENT, MANAGEMENT, UTILIZATION, AND CONSERVATION OF THE NATION'S OCEAN, COASTAL, AND GREAT LAKES RESOURCES. THESE IMPORTANT EFFORTS PROMOTE A STRONG EDUCATIONAL BASE, RESPONSIVE RESEARCH AND TRAINING ACTIVITIES, BROAD AND PROMPT DISSEMINATION OF KNOWLEDGE AND TECHNIQUES, AND MULTIDISCIPLINARY APPROACHES TO ENVIRONMENTAL PROBLEMS, IN ACCORDANCE WITH 33 U.S.C. 1121(B). SPECIFIC OUTCOMES IDENTIFIED BY THE RECIPIENT INCLUDE, BUT ARE NOT LIMITED TO: RESOURCE MANAGERS ARE INFORMED OF ADVANCES IN THE SCIENTIFIC UNDERSTANDING OF ORGANISMS, HABITATS, AND ECOSYSTEM FUNCTION, AND ANTHROPOGENIC DISTURBANCES TO HELP MAKE SOUND RESOURCE MANAGEMENT DECISIONS. COMMUNITIES RECEIVE TARGETED INFORMATION AND TECHNIQUES TO HELP THEM ENHANCE THEIR ECONOMIC ACTIVITIES WITHOUT DIMINISHING THE LONG-TERM HEALTH OF THE NATURAL ENVIRONMENT OR COMMUNITY CHARACTER. RESULTS OF DELAWARE SEA GRANT COMPETITIVELY-AWARDED RESEARCH PROJECTS WILL BE COMMUNICATED WITH FISHERIES MANAGERS AND INDUSTRY AGENTS THROUGH PRESENTATIONS, PEER-REVIEWED ARTICLES, OUTREACH MATERIALS, AND TECHNICAL PUBLICATIONS TO ASSIST IN IMPROVED MANAGEMENT OF FISHERIES RESOURCES. DELAWARE SEA GRANT DELIVERS COASTAL AND MARINE SCIENCE AND POLICY CAREER INFORMATION IN PERSON AND ONLINE TO K-12 AUDIENCES THROUGH IN-SCHOOL, AFTER-SCHOOL, AND ONLINE PROGRAMMING LEADING TO MORE STUDENTS PURSUING SCIENCE-RELATED OPPORTUNITIES IN THE FUTURE. INTENDED BENEFICIARIES: RESIDENTS, STAKEHOLDERS, AND DECISION-MAKERS OF THE STATE OF DELAWARE AS WELL AS THROUGHOUT THE MID-ATLANTIC REGION. SUBRECIPIENT ACTIVITIES: THE RECIPIENT PLANS TO SUBAWARD FUNDS TO PRINCIPAL INVESTIGATORS THROUGHOUT THE STATE OF DELAWARE WHO SUCCESSFULLY COMPETED FOR FUNDING FOLLOWING THE NATIONAL SEA GRANT COLLEGE PROGRAM'S COMPETITION POLICY. ADDITIONALLY, FUNDING MAY BE SUBAWARDED FOR EXTENSION OR EDUCATION WORK.

COMPOSITES RESEARCH, ENGINEERING AND ADVANCED TECHNOLOGY (CREATE)

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

CENTER FOR NEUTRON SCIENCE AT THE UNIVERSITY OF DELAWARE: NEUTRON METROLOGY FOR SOLVING GRAND CHALLENGE PROBLEMS BY ENGINEERING THE TOOLS OF SCIENTIFIC DISCOVERY

SCIPE: BUILDING A COMPUTATIONAL AND DATA-INTENSIVE RESEARCH WORKFORCE & NETWORK IN THE MID-ATLANTIC REGION -WITH RAPID ADVANCES IN HARDWARE ARCHITECTURE AND SOFTWARE ECOSYSTEM, THERE IS A CRUCIAL NEED TO MODERNIZE APPLICATIONS AND LEVERAGE THE ADVANCEMENTS IN HIGH PERFORMANCE COMPUTING (HPC), ARTIFICIAL INTELLIGENCE (AI), MACHINE LEARNING (ML) AND DATA SCIENCE. THESE ADVANCEMENTS CAN ONLY BE ACHIEVED BY CREATING PARTNERSHIPS BETWEEN DOMAIN SCIENTISTS AND COMPUTATIONAL EXPERTS. SUCH COLLABORATIONS WILL HELP BUILD A TRAINED AND SKILLED WORKFORCE CAPABLE OF HARNESSING THE BENEFITS OF MODERN HARDWARE AND SOFTWARE IN A MANNER THAT ALIGNS WITH DOMAIN SCIENCE PERSPECTIVES. THIS PROJECT ADDRESSES THIS NEED BY CREATING A TEAM OF CYBERINFRASTRUCTURE PROFESSIONALS (ALSO CALLED RESEARCH SOFTWARE ENGINEERS (RSES)) TO SUPPORT COMPUTATIONAL AND DATA-INTENSIVE RESEARCH IN THE MID-ATLANTIC REGION. THIS TEAM FOCUSES ON IMPROVING RSE SKILLS AND SUPPORT TO ADVANCE (I) SOCIAL, BEHAVIORAL, AND ECONOMIC (SBE) SCIENCES AND (II) COASTAL SCIENCES AND INFRASTRUCTURE (CSI). THE UNIVERSITY OF DELAWARE (UD) WILL IMPLEMENT THE PROPOSED WORK IN CLOSE COLLABORATION WITH HOWARD UNIVERSITY, DELAWARE STATE UNIVERSITY, AND LINCOLN UNIVERSITY?THREE MINORITY SERVING INSTITUTIONS (MSIS). THE PROJECT ADDRESSES THE CHALLENGE OF BUILDING AND SUSTAINING RSE TEAMS BY OFFERING TRAINING, EDUCATION, AND CERTIFICATION, AS WELL AS CAREER DEVELOPMENT PROGRAMS. THE GOAL IS TO ENSURE THE RECOGNITION, RECRUITMENT, AND RETENTION OF RSES, MAKING THE TEAM A ROLE MODEL AND A STEADY SOURCE OF FUTURE RSES. VIA AN INTER-INSTITUTIONAL INITIATIVE, THIS PROJECT IS (A) IDENTIFYING AND CREATING A SUSTAINABLE AND SCALABLE TALENT PIPELINE OF RSES TO ACCELERATE AND ENABLE DOMAIN SCIENCES, ESPECIALLY THE SBE AND CSI DOMAIN AREAS TRADITIONALLY UNDERSERVED BY RSES, (B) CONNECTING RSES FROM OTHER INITIATIVES SUCH AS ACCESS, SCIPE, AND US-RSE TO FOSTER A BROADER NETWORK, (C) ESTABLISHING A GRADUATE LEVEL COURSE AND RSE PILOT CERTIFICATE, AND (D) STUDYING THE NOVEL APPLICABILITY OF DATA-DRIVEN ML/AI METHODS AND HPC ON THE DOMAIN SCIENCE PROBLEMS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

THE PROPOSED ACTIVITY IS A WORKFORCE DEVELOPMENT PROJECT WITH A SPECIFIC FOCUS ON THE DEVELOPMENT OF A RAILROAD ENGINEERING PROGRAM BY THE UNIVERSITY OF DELAWARE FOR IMPLEMENTATION AT MORGAN STATE UNIVERSITY (MSU), A HISTORICALLY BLACK COLLEGE AND UNIVERSITY (HBCU) LOCATED IN BALTIMORE, MARYLAND. THIS DEVELOPMENT AND IMPLEMENTATION ACTIVITY WILL SERVE AS A TEMPLATE AND MODEL FOR IMPLEMENTATION OF SIMILAR PROGRAMS AT OTHER HBCUS IN OTHER PARTS OF THE UNITED STATES. THE ULTIMATE GOALS ARE TO TRAIN MORE STAKEHOLDERS AND INCREASE THE WORKFORCE DIVERSITY.

COBRE: MEMBRANE PROTEIN PRODUCTION AND CHARACTERIZATION

VASCULAR EFFECTS OF DIETARY SALT IN HUMANS WITH SALT-RESISTANT BP

TAS::89 0336::TAS RECOVERY VEHICLE TECHNOLOGIES NOVEL HIGH ENERGY DENSITY, LOW RARE-EARTH CONTENT MAGNETIC MATERIALS WITH DOUBLE THE ENERGY DENSIT

FLAVOPROTEINS IN OXIDATIVE PROTEIN FOLDING

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE PRIMARY PURPOSE OF THE NORTHEAST CENTER IS TO FULFILL USDA'S GOAL OF ENSURING A STRONG FARM FINANCIAL SAFETY NET BY PROVIDING U.S. AGRICULTURAL PRODUCERS AND THEIR FAMILIES, AS APPROPRIATE, WITH KNOWLEDGE, SKILLS AND TOOLS NEEDED TO MAKE INFORMED RISK MANAGEMENT DECISIONS THAT MAY ENHANCE THE PROFITABILITY OF THEIR OPERATIONS. THE CENTER, IN CONJUNCTION WITH THE OTHER REGIONAL CENTERS, ANNUALLY CONDUCTS THE EXTENSION RISK MANAGEMENT EDUCATION (ERME) COMPETITIVE GRANTS PROGRAM. THE ERME PROGRAM PROVIDES FUNDING TO BOTH PUBLIC AND PRIVATE ORGANIZATIONS FOR EDUCATIONAL PROJECTS DESIGNED TO IMPROVE THE ABILITY OFAGRICULTURAL PRODUCERS TO EFFECTIVELY MANAGE THE RISKS ASSOCIATED WITH THEIR AGRIBUSINESSES. THIS PROGRAM'S MISSION - EDUCATING AMERICA'S FARMERS AND RANCHERS TO MANAGE THE UNIQUE RISKS OF PRODUCING FOOD FOR THE WORLD'S TABLE. A KEY FEATURE OF THE PRODUCER-FOCUSED PROGRAM IS THAT IT IS RESULTS-BASED - AWARDS ARE MADE TO PROJECT DIRECTORS WHO CLEARLY IDENTIFY RISK MANAGEMENT RESULTS FOR THE PARTICIPANTS. THE RESULTS ARE THE SPECIFIC, MEASURABLE AND VERIFIABLE RISK MANAGEMENT OUTCOMES THAT PRODUCERS WILL UNDERSTAND, ANALYZE, DEVELOP, DECIDE OR IMPLEMENT IN MANAGING THEIR AGRIBUSINESSES, AND WHICH WILL ULTIMATELY ENHANCE THEIR ECONOMIC VIABILITY. AS INVESTORS OF THE FEDERAL RESOURCES DESIGNATED FOR RISK MANAGEMENT EDUCATION THROUGH ARPA, THE ERME CENTERS (AND THUS NIFA) ARE NOT FUNDING PROJECT TEAM ACTIVITIES, BUT RATHER A CHANGE IN RISK MANAGEMENT BEHAVIOR FOR A GROUP OF PARTICIPATING PRODUCERS. IN ITS ROLE AS A REGIONAL RESOURCE, THE NORTHEAST CENTER PROVIDES LEADERSHIP AND COORDINATION, ESTABLISHES PRIORITIES FOR RME PROGRAMMING, AND DISSEMINATES INFORMATION REGARDING RISK MANAGEMENT ACTIVITIES OCCURRING THROUGHOUT THE NORTHEAST AND THE NATION. TODAY'S FARMERS AND RANCHERS FACE AN UNPRECEDENTED RISK ENVIRONMENT, AND WHEN A SPECIFIC EDUCATIONAL NEED ARISES, THE NORTHEAST CENTER POSSESSES THE CONTACTS AND THE RESOURCES TO ENSURE THAT THE NEED IS PROMPTLY ADDRESSED.

CZO: SPATIAL AND TEMPORAL INTEGRATION OF CARBON AND MINERAL FLUXES: A WHOLE WATERSHED APPROACH TO QUANTIFYING ANTHROPOGENIC MODIFICATION OF CRITICAL

THE PRIMARY PURPOSE OF THE NORTHEAST CENTER IS TO FULFILL USDA'S GOAL OF ENSURING A STRONG FARM FINANCIAL SAFETY NET BY PROVIDING U.S. AGRICULTURAL PRODUCERS AND THEIR FAMILIES, AS APPROPRIATE, WITH KNOWLEDGE, SKILLS AND TOOLS NEEDED TO MAKE INFORMED RISK MANAGEMENT DECISIONS THAT MAY ENHANCE THE PROFITABILITY OF THEIR OPERATIONS. THE CENTER, IN CONJUNCTION WITH THE OTHER REGIONAL CENTERS, ANNUALLY CONDUCTS THE EXTENSION RISK MANAGEMENT EDUCATION (ERME) COMPETITIVE GRANTS PROGRAM. THE ERME PROGRAM PROVIDES FUNDING TO BOTH PUBLIC AND PRIVATE ORGANIZATIONS FOR EDUCATIONAL PROJECTS DESIGNED TO IMPROVE THE ABILITY OF AGRICULTURAL PRODUCERS TO EFFECTIVELY MANAGE THE RISKS ASSOCIATED WITH THEIR AGRIBUSINESSES. THIS PROGRAM'S MISSION, "EDUCATING AMERICA'S FARMERS AND RANCHERS TO MANAGE THE UNIQUE RISKS OF PRODUCING FOOD FOR THE WORLD'S TABLE", IS DIRECTLY ALIGNED WITH USDA STRATEGIC GOALS FOR 2018-2022. A KEY FEATURE OF THE PRODUCER-FOCUSED PROGRAM IS THAT IT IS "RESULTS-BASED" - AWARDS ARE MADE TO PROJECT DIRECTORS WHO CLEARLY IDENTIFY RISK MANAGEMENT RESULTS FOR THE PARTICIPANTS. THE RESULTS ARE THE SPECIFIC, MEASURABLE AND VERIFIABLE RISK MANAGEMENT OUTCOMES THAT PRODUCERS WILL UNDERSTAND, ANALYZE, DEVELOP, DECIDE OR IMPLEMENT IN MANAGING THEIR AGRIBUSINESSES, AND WHICH WILL ULTIMATELY ENHANCE THEIR ECONOMIC VIABILITY. AS INVESTORS OF THE FEDERAL RESOURCES DESIGNATED FOR RISK MANAGEMENT EDUCATION THROUGH ARPA, THE ERME CENTERS (AND THUS NIFA) ARE NOT FUNDING PROJECT TEAM ACTIVITIES, BUT RATHER A CHANGE IN RISK MANAGEMENT BEHAVIOR FOR A GROUP OF PARTICIPATING PRODUCERS. IN ITS ROLE AS A REGIONAL RESOURCE, THE NORTHEAST CENTER PROVIDES LEADERSHIP AND COORDINATION, ESTABLISHES PRIORITIES FOR RME PROGRAMMING, AND DISSEMINATES INFORMATION REGARDING RISK MANAGEMENT ACTIVITIES OCCURRING THROUGHOUT THE NORTHEAST AND THE NATION. TODAY'S FARMERS AND RANCHERS FACE AN UNPRECEDENTED RISK ENVIRONMENT, AND WHEN A SPECIFIC EDUCATIONAL NEED ARISES, THE NORTHEAST CENTER POSSESSES THE CONTACTS AND THE RESOURCES TO ENSURE THAT THE NEED IS PROMPTLY ADDRESSED.

DESGC GOALS ARE: (I) DEVELOP A NETWORK OF EDUCATIONAL UNITS WITH INTERESTS AND CAPABILITIES IN STEM SUBJECTS LINKED WITH NASA AND OTHER NATIONAL AEROSPACE RESOURCES (II) STIMULATE SUPPORT AND COORDINATE INTERDISCIPLINARY INTER-UNIVERSITY AND UNIVERSITY/INDUSTRY RESEARCH JOB TRAINING AND EDUCATIONAL PROGRAMS (III) WORK WITH EDUCATORS INDUSTRY AND GOVERNMENT TO PROMOTE STRONG STEM EDUCATION AT ALL LEVELS AND (IV) PROVIDE SUPPORT FOR PROFESSIONAL DEVELOPMENT OF PRE-COLLEGE EDUCATORS.

TOOLKIT FOR FAST, MULTIPURPOSE AND INDUCIBLE BIOORTHOGONAL CHEMISTRY

THIS COOPERATIVE AGREEMENT IS AWARDED TO THE UNIVERSITY OF DELAWARE FOR A PROJECT ENTITLED ''BIOENERGY PRODUCTION BASED ON AN ENGINEERED MIXOTROPHIC COCULTURE FOR ENHANCED CO2 FIXATION.'' THIS AWARD IS BEING MADE IN ACCORDANCE WITH FOA NUMBER DE-FOA-0002387(ECOSYNBIO) AND APPLICATION CONTROL NUMBER 2387-1513.

AN INVERSE DESIGN METHODOLOGY TO FABRICATE LOW-COST AGILE TOOLS FOR MANUFACTURING LIGHTWEIGHT AUTOMOTIVE COMPONENTS

EQUIPMENT: MRI: TRACK 2 ACQUISITION OF A 600 MHZ DYNAMIC NUCLEAR POLARIZATION NMR SYSTEM FOR INTERDISCIPLINARY RESEARCH, EDUCATION, AND TRAINING -AN AWARD IS MADE TO THE UNIVERSITY OF DELAWARE TO ACQUIRE A 600 MHZ SOLID-STATE DYNAMIC NUCLEAR POLARIZATION (DNP) SYSTEM TO ENABLE RESEARCH ACROSS VARIOUS SCIENTIFIC DISCIPLINES. THIS NEW INSTRUMENT WILL SIGNIFICANTLY ENHANCE THE SCIENTIFIC INFRASTRUCTURE IN THE MID-ATLANTIC, NORTHEAST, AND ?RUST BELT? REGIONS BY PROVIDING ACCESS TO UNIQUE DNP NUCLEAR MAGNETIC RESONANCE (NMR) CAPABILITIES FOR CUTTING-EDGE SCIENTIFIC DISCOVERIES. THE INSTRUMENT WILL SERVE AS A VITAL REGIONAL RESOURCE FOR NUMEROUS ACADEMIC AND INDUSTRIAL PARTNERS, FACILITATING THE DEVELOPMENT OF NEW COLLABORATIONS AND DRIVING INNOVATIVE PROJECTS. ACCESS TO THIS STATE-OF-THE-ART TECHNOLOGY WILL PROVIDE EXCEPTIONAL TRAINING OPPORTUNITIES FOR GRADUATE, UNDERGRADUATE, AND POSTDOCTORAL STUDENTS. THE OUTREACH PROGRAM INCLUDES A RICH ARRAY OF SOCIETALLY BENEFICIAL ACTIVITIES AIMED AT SHARING ADVANCED NMR CAPABILITIES WITH THE BROADER COMMUNITY, INCREASING PUBLIC AWARENESS OF NSF-FUNDED RESEARCH, AND CONTRIBUTING TO THE DEVELOPMENT OF AN EFFECTIVE AND HIGHLY SKILLED STEM WORKFORCE. THE SCIENCE ENABLED BY THE NEW SPECTROMETER WILL IMPACT MULTIPLE FIELDS, INCLUDING CHEMISTRY, CHEMICAL AND BIOMOLECULAR ENGINEERING, FUNDAMENTAL BIOPHYSICS, NMR SPECTROSCOPY, STRUCTURAL BIOCHEMISTRY, MOLECULAR CELL BIOLOGY, MATERIAL SCIENCES, BIOTECHNOLOGY, AND MARINE SCIENCES. THE SIGNIFICANT SENSITIVITY ENHANCEMENTS ACHIEVED IN DNP EXPERIMENTS WILL FACILITATE THE INVESTIGATIONS OF A WIDE VARIETY OF SYSTEMS PREVIOUSLY INACCESSIBLE WITH CURRENT INSTRUMENTATION, SUCH AS INTACT CELLS OR ORGANISMS, MACROMOLECULAR ASSEMBLIES, POLYMERS, BIOLOGICS, HIGHLY COMPLEX ORGANIC MIXTURES, SURFACES, AND ENGINEERED MATERIALS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

MICROBIAL COMMUNITY ENGINEERING TOOLS FOR ENHANCING WASTE PLASTIC DEGRADATION AND VALORIZATION

GENETIC AND HISTOLOGICAL DISSECTION OF PHENOTYPIC VARIATION IN QUANTITATIVE RESISTANCE TO MAIZE DISEASES

PROMOTING RECOVERY OPTIMIZATION WITH WALKING EXERCISE AFTER STROKE (PROWALKS)

INDUSTRY 4.0 IMPLEMENTATION IN CONTINUOUS PHARMACEUTICAL MANUFACTURING

DISC MECHANICS AND ALTERED LOADING IN DEGENERATION

DELAWARE AND NEW JERSEY CJ-DATS RESEARCH CENTER

DYNAMIC STABILITY IN THE ACL INJURED KNEE

ADVANCING NEUTRON SCATTERING METROLOGY(SANS, VSANS, NEUTRON REFLECTOMETRY AND NSE)FOR SUSTAINABLE ENERGY, HUMAN HEALTH, AND NANOMATERIALS RESEARCH

LEADERSHIP EDUCATION IN NEURODEVELOPMENTAL AND RELATED DISORDERS TRAINING PROGRAM

GCR: LIFE CYCLE MANAGEMENT OF MATERIALS: SUSTAINABLE BIOMASS TO DESIGNER POLYMER SYSTEMS

MEASURING SYMPTOM CLUSTERS IN PEOPLE WITH SUDDEN-ONSET DISABILITIES

ADVANCED METROLOGY USING USANS SANS NEUTRON REFLECTOMETRY AND NSE IN SUPPORT OF SUSTAINABLE ENERGY HEALTH AND NANOMATERIALS RESEARCH.

ADVANCING CONTINUOUS BIOMANUFACTURING OF MONOCLONAL ANTIBODIES USING AN EXPERIMENTALLY VALIDATED MODELING PLATFORM - PROJECT SUMMARY DUE TO INCREASED DEMAND FOR BIOLOGICS, THERE IS AN ONGOING NEED TO SCIENTIFICALLY AND COMMERCIALLY ADVANCE MANUFACTURING IN BOTH UPSTREAM CELL CULTURE AND DOWNSTREAM PURIFICATION STEPS. OUR GOAL IS TO PROVIDE AN EXPERIMENTAL INFRASTRUCTURE COMPLEMENTED BY A COMPUTATIONAL FRAMEWORK TO INVESTIGATE THE CONTINUOUS MANUFACTURING OF MONOCLONAL ANTIBODIES (MABS). THE MODELING APPROACH WILL BE BASED AND VALIDATED USING SPECIFIC EXPERIMENTAL EVIDENCE TO ENHANCE OUR PROCESS UNDERSTANDING AND IMPROVE MODEL PERFORMANCE AND UTILIZATION DURING THE DESIGN PHASE. THE PROPOSED INNOVATIONS STEM FROM THE FOLLOWING OBJECTIVES THAT WILL BE DELIVERED AS THE OUTCOME OF THIS PROJECT, NAMELY, 1) TO DEVELOP A MULTISCALE MODEL FOR PERFUSION BIOREACTOR CAPTURING THE EFFECTS OF OPERATING PARAMETERS AND CELL LINE CHARACTERISTICS ON CRITICAL QUALITY ATTRIBUTES (CQAS) VALIDATED BY EXPERIMENTAL RESULTS; 2) TO DEVELOP METHODS FOR OPTIMIZING CONTINUOUS CHROMATOGRAPHIC OPERATIONS, INCLUDING PRIMARY CAPTURE AND POLISHING STEPS, UNDER A RANGE OF PROCESS CONDITIONS FOR OPTIMAL CLEARANCE OF PROCESS- AND PRODUCT-RELATED IMPURITIES; AND 3) TO DEVELOP PREDICTIVE MODELS THAT WILL ENABLE DETERMINATION OF OPTIMAL OPERATING CONDITIONS WITH DIRECT COUPLING OF UPSTREAM AND DOWNSTREAM UNITS ACCOUNTING FOR PRODUCT QUALITY ATTRIBUTES. TO ENABLE PROCESS CONTROL, WHICH IS THE ULTIMATE TARGET OF ADVANCED MANUFACTURING, WE WILL EXPLORE THE DESIGN SPACE AND IDENTIFY THE RELATIONSHIPS BETWEEN CRITICAL PROCESS PARAMETERS (CPPS), CRITICAL MATERIAL ATTRIBUTES (CMAS), AND TARGETED CQAS. WE WILL DEVELOP PREDICTIVE MODELS FOR ALL THE IMPORTANT UNIT OPERATIONS, VALIDATED BY EXPERIMENTS, THAT CAN BE USED TO DETERMINE THE DESIGN SPACE ALONG WITH STATISTICAL ANALYSIS OF EXPERIMENTAL DATA TO IDENTIFY ALL CRITICAL PARAMETERS/ATTRIBUTES. THE VALIDATED MODELS WILL THEN BE USED AS A VIRTUAL TOOL TO PERFORM RISK ASSESSMENT FOR IN-PLANT DOWNSTREAM OPERATIONS SUCH AS SCALE-UP/START-UP/SHUTDOWN AND COMPARE PROCESS OPERATING SCENARIOS. IN TERMS OF COMBINING THE DEVELOPED STRATEGIES, WE ENVISION THE INTEGRATION WITH A CONTINUOUS UPSTREAM FACILITY TO ACHIEVE A FULLY AUTOMATED CONTINUOUS BIOMANUFACTURING LINE EXPLORING AND OPTIMIZING THE PROCESS INTERACTIONS. THIS PROOF-OF-CONCEPT LINE WILL BE USED TO CLEARLY QUANTIFY RISK AND PERFORMANCE-BASED METRICS.

COLLABORATIVE RESEARCH: FEC: TRI-STATE COLLABORATIVE FOR DEFLUORINATION OF PER- AND POLYFLUOROALKYL SUBSTANCES -PER- AND POLYFLUOROALKYL SUBSTANCES (PFAS) ARE SYNTHETIC CHEMICALS, AND CERTAIN LEGACY PFAS MAY POSE HEALTH AND ENVIRONMENTAL RISKS DUE TO THE STRONG CHEMICAL BONDS. THIS PROJECT ADDRESSES THE CHALLENGE OF PFAS REMOVAL AND CONVERSION BY INTEGRATING EXPERTISE IN MATERIALS SCIENCE, SEPARATIONS, REACTION ENGINEERING, ELECTROCHEMISTRY, PROCESS SYSTEMS, MULTISCALE MODELING, ARTIFICIAL INTELLIGENCE, AND SOCIAL SCIENCE. SPANNING DELAWARE, ALABAMA, AND SOUTH CAROLINA, THE PROJECT AIMS TO BUILD REGIONAL RESEARCH CAPACITY AND INFRASTRUCTURE TO SUPPORT PFAS MITIGATION WITHIN A CIRCULAR ECONOMY FRAMEWORK. LED BY THE UNIVERSITY OF DELAWARE, IN COLLABORATION WITH DELAWARE STATE UNIVERSITY, UNIVERSITY OF ALABAMA AT HUNTSVILLE, ALABAMA A&M UNIVERSITY, UNIVERSITY OF SOUTH CAROLINA, CLEMSON UNIVERSITY, AND BENEDICT COLLEGE, THE PROJECT HAS THE POTENTIAL TO REVOLUTIONIZE DEFLUORINATION TECHNOLOGIES ACROSS WATER, AIR, AND SOIL, IMPACTING MEDICAL, AGRICULTURAL, AND INDUSTRIAL SECTORS. EDUCATION AND OUTREACH EFFORTS WILL TRAIN SKILLED EDUCATORS, SCIENTISTS, AND ENGINEERS TO TACKLE PFAS CHALLENGES AND ADVANCE NATIONAL HEALTH, PROSPERITY, AND ECONOMIC GROWTH. THE PROJECT WILL EMPLOY A MULTI-SCALE RESEARCH FRAMEWORK, INTEGRATING EXPERIMENTS AND MODELING, TO CREATE INNOVATIVE KNOWLEDGE AND ROBUST TECHNOLOGIES FOR PFAS SEPARATION AND CONVERSION, AIMING FOR NEAR-ZERO FLUORO-POLLUTION. IT WILL ADDRESS CRITICAL KNOWLEDGE GAPS IN PFAS CONCENTRATION AND DEFLUORINATION WITHIN A CIRCULAR ECONOMY CONTEXT, WHILE TACKLING ENGINEERING CHALLENGES, SUCH AS COMPLEX WATER MATRICES, PILOT-SCALE TESTING, AND ENVIRONMENTAL AND COST ANALYSES. THE MAJOR RESEARCH GOALS INCLUDE: (I) ADVANCING PFAS ADSORPTION AND ELECTROCHEMICAL SEPARATION ACROSS DIVERSE WATER SOURCES; (II) UNCOVERING MECHANISMS FOR SELECTIVE ELECTROCHEMICAL AND PLASMA-ASSISTED PFAS REDUCTION; AND (III) DESIGNING ENERGY-EFFICIENT, MODULAR SYSTEMS THAT COUPLE UP-CONCENTRATION WITH REDUCTION PROCESSES. THE PROJECT WILL STRENGTHEN STEM CAPACITY AND RESEARCH INFRASTRUCTURE ACROSS THREE EPSCOR JURISDICTIONS BY BUILDING PFAS EXPERTISE, LAUNCHING SUSTAINABLE STEM EDUCATION AND TRAINING PROGRAMS ACROSS SEVEN PARTNER INSTITUTIONS, AND FOSTERING LONG-TERM COLLABORATION WITH NATIONAL LABS, INDUSTRY, AND COMMUNITIES TO CULTIVATE A DIVERSE NEW GENERATION OF INNOVATORS AND EDUCATORS. THIS PROJECT IS SUPPORTED BY THE EPSCOR RESEARCH INFRASTRUCTURE IMPROVEMENT PROGRAM: FOCUSED EPSCOR COLLABORATIONS (FEC), WHICH SUPPORTS INTERJURISDICTIONAL TEAMS OF EPSCOR INVESTIGATORS TO PERFORM RESEARCH IN TOPICS THAT ALIGN WITH NSF PRIORITIES, WITH THE GOALS OF DRIVING DISCOVERY AND BUILDING SUSTAINABLE STEM CAPACITY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

TESTING A DUAL MECHANISM MODEL OF ADOLESCENT ANXIETY DEVELOPMENT & RELATED SEX DIFFERENCES - ABSTRACT ANXIETY DISORDERS REMAIN ONE OF THE MOST COMMON FORMS OF MENTAL ILLNESS AND THE 6TH LEADING CAUSE OF DISABILITY WORLDWIDE. ANXIETY PATHOLOGY TENDS TO EMERGE DURING EARLY ADOLESCENCE, AND THIS PROCESS OCCURS DIFFERENTIALLY BETWEEN THE SEXES, WITH RATES BECOMING 2- TO 3-FOLD HIGHER IN GIRLS (VS. BOYS) POST-PUBERTY. THUS, IDENTIFYING ADOLESCENCE-SPECIFIC FACTORS THAT PREDISPOSE TOWARDS ANXIETY DISORDERS IS CRUCIAL FOR IDENTIFYING AT-RISK INDIVIDUALS EARLY, BEFORE TRAJECTORIES CRYSTALIZE, AND FOR PROVIDING NOVEL INTERVENTION TARGETS. INTERESTINGLY, THE DEVELOPMENTAL COURSE OF ANXIETY IS INVERSELY RELATED TO THE MATURATION OF EMOTION-REGULATION CAPACITY, WITH DECREMENTS IN CAPACITY APPEARING DURING THE TRANSITION INTO ADOLESCENCE. WE AND OTHERS HAVE PROPOSED THAT THE DEVELOPMENT OF ADOLESCENT ANXIETY IS DUE, IN PART, TO DIFFERENCES IN THE MATURATIONAL TRAJECTORIES OF BRAIN NETWORKS SUPPORTING EMOTION REGULATION (I.E., EMOTION DYSREGULATION IS A KEY ENDOPHENOTYPE FOR ANXIETY DEVELOPMENT). HOWEVER, THE ADOLESCENT- AND SEX-SPECIFIC NEUROBIOLOGICAL MECHANISMS THAT SUPPORT THE DEVELOPMENT OF EMOTION REGULATION, AND THEIR IMPLICATIONS FOR THE MANIFESTATION OF ANXIETY PATHOLOGY, ARE NOT WELL UNDERSTOOD. WE WILL TEST A MODEL INCORPORATING TWO RISK FACTORS: PUBERTAL TESTOSTERONE AND AXONAL MYELINATION OF PREFRONTAL-SUBCORTICAL CIRCUITS. WE WILL COLLECT LONGITUDINAL (3 WAVES, EACH 1 YEAR APART) MULTI-MODAL (E.G., DIFFUSION, ULTRA-FAST FMRI) NEUROIMAGING DATA FROM INDIVIDUALS AT THE TRANSITION INTO ADOLESCENCE, HALF OF WHOM ARE AT HIGH RISK FOR DEVELOPING AN ANXIETY DISORDER. AIM 1: WE RECENTLY PROPOSED A MODEL IN WHICH TESTOSTERONE DAMPENS THE EFFECTIVENESS OF KEY EMOTION-REGULATION CIRCUITRY, WHEREAS MYELINATION OF WHITE MATTER IN THAT CIRCUIT HAS THE OPPOSITE EFFECT. AIM 1 WILL EVALUATE THIS MODEL BY TESTING WHETHER (I) INCREASES OVER TIME IN PUBERTAL TESTOSTERONE ARE LINKED TO FUNCTIONAL DECOUPLING BETWEEN ORBITOFRONTAL CORTEX (OFC) AND AMYGDALA AND (II) THIS DECOUPLING PREDICTS EMOTION DYSREGULATION AND CONSEQUENT ANXIETY INCREASES. THIS AIM WILL ALSO TEST WHETHER SPARSER BASELINE MYELINATION OF UNCINATE FASCICULUS (CONNECTING OFC-AMYGDALA) IS LINKED TO WEAKER FUNCTIONAL COUPLING, HIGHER DYSREGULATION, AND ANXIETY. AIM 2: THE BIOLOGICAL MECHANISMS THAT CONFER GREATER RISK FOR ANXIETY IN FEMALES REMAIN UNKNOWN. OUR WORK IN HEALTHY ADOLESCENTS SUGGESTS THAT FEMALES HAVE A HIGHER SENSITIVITY TO TESTOSTERONE IN THE OFC- AMYGDALA CIRCUIT, AND THERE IS SOME EVIDENCE OF MYELINATION DIFFERENCES IN THIS CIRCUIT. AIM 2 WILL TEST WHETHER TESTOSTERONE AND MYELINATION HAVE A GREATER IMPACT ON EMOTION-REGULATION CIRCUITRY/PATHOLOGICAL ANXIETY IN GIRLS. AIM 3: IT IS CRITICAL TO IDENTIFY BASELINE BIOMARKERS PREDICTIVE OF FUTURE ANXIETY DEVELOPMENT IN ORDER TO DETECT AT- RISK INDIVIDUALS BEFORE TRAJECTORIES CRYSTALIZE. AIM 3 WILL TEST WHETHER TESTOSTERONE AND MYELINATION CAN BE USED TO PREDICT THE EMERGENCE OF FUTURE ANXIETY. IN SUM, THIS PROJECT AIMS TO IDENTIFY NEURAL AND HORMONAL MECHANISMS RESPONSIBLE FOR THE DEVELOPMENT OF ADOLESCENT ANXIETY. THIS WORK HAS THE POTENTIAL FOR TREMENDOUS PUBLIC HEALTH IMPACT BY HARNESSING CUTTING-EDGE METHODS TO UNCOVER AND VALIDATE NOVEL RISK TRAJECTORIES FOR ANXIETY.

PARTICLE THEORY AND COSMOLOGY

SOLUTE TRANSPORT IN THE BONE LACUNAR-CANALICULAR SYSTEM

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

E-RISE RII: AN INVESTIGATION OF SALTWATER INTRUSION IN THE COMPLEX COASTAL ENVIRONMENT OF DELAWARE -THIS PROJECT WILL INVESTIGATE THE CRITICAL ISSUE OF SALTWATER INTRUSION IN DELAWARE'S COMPLEX COASTAL ENVIRONMENT. SALTWATER INTRUSION, THE MOVEMENT OF SEAWATER INTO FRESHWATER RESOURCES, POSES SIGNIFICANT THREATS TO THE STATE'S DRINKING WATER SUPPLIES, AGRICULTURE, NATURAL ECOSYSTEMS, AND INFRASTRUCTURE. THIS PROJECT AIMS TO ADVANCE UNDERSTANDING OF THE PROCESSES DRIVING SALTWATER INTRUSION AND DEVELOP STRATEGIES TO MITIGATE ITS IMPACTS. THE RESEARCH TEAM, CONSISTING OF FACULTY, STAFF, AND STUDENTS FROM DELAWARE STATE UNIVERSITY, DELAWARE TECHNICAL COMMUNITY COLLEGE, GOLDEY-BEACOM COLLEGE, WILMINGTON UNIVERSITY, AND UNIVERSITY OF DELAWARE, WILL COLLABORATE WITH PARTNERS ACROSS THE STATE TO ADDRESS THIS PRESSING CHALLENGE. THEY WILL COLLECT FIELD DATA, CONDUCT EXPERIMENTS, AND DEVELOP COMPUTER MODELS TO STUDY HOW VARIOUS FACTORS AFFECT SALTWATER INTRUSION IN URBAN, SUBURBAN, RURAL, AND NATURAL AREAS. THE PROJECT WILL ALSO EXPLORE INNOVATIVE SOLUTIONS, SUCH AS DEVELOPING SALINITY-RESISTANT CROPS, FACILITATING MARSH MIGRATION, AND PROMOTING WETLAND-BASED CARBON REMOVAL. BY ENGAGING PARTNERS THROUGHOUT THE STATE AND TRAINING THE NEXT GENERATION OF SOCIAL AND NATURAL SCIENTISTS AND ENGINEERS, THE PROJECT AIMS TO ENHANCE REGIONAL RESILIENCE AND PROMOTE LONG-TERM ECONOMIC WELL-BEING. ULTIMATELY, THE PROJECT WILL PROVIDE VITAL INFORMATION TO SUPPORT SUSTAINABLE WATER MANAGEMENT, PROTECT DELAWARE'S VALUABLE WATER RESOURCES, AND ENSURE A RESILIENT FUTURE FOR COASTAL COMMUNITIES IN DELAWARE AND BEYOND. THE PROJECT WILL EMPLOY A CONVERGENT, MULTIDISCIPLINARY APPROACH TO ELUCIDATE THE COMPLEX HYDROLOGIC, GEOLOGIC, BIOGEOCHEMICAL, ECONOMIC, AND SOCIAL FACTORS IMPACTING SALTWATER INTRUSION IN DELAWARE'S COASTAL ENVIRONMENTS. THE PROJECT TEAM WILL ESTABLISH A NETWORK OF MONITORING WELLS TO CONTINUOUSLY MEASURE GROUNDWATER SALINITY, COLLECT GEOPHYSICAL DATA TO CHARACTERIZE SUBSURFACE AQUIFER STRUCTURE, AND USE ADVANCED GEOCHEMICAL TRACERS TO FINGERPRINT THE SOURCES AND PATHWAYS OF SALTWATER INTRUSION. HIGH-RESOLUTION NUMERICAL MODELS, COUPLING SURFACE WATER AND GROUNDWATER DYNAMICS, WILL BE DEVELOPED TO SIMULATE THE INTERPLAY BETWEEN VARIOUS ENVIRONMENTAL FACTORS, GROUNDWATER ABSTRACTION, AND HUMAN DECISION-MAKING ON SALTWATER INTRUSION. THE PROJECT WILL INVESTIGATE THE PHYSICAL RISKS (HAZARDS, EXPOSURE, AND VULNERABILITIES) AND ASSESS HOW PEOPLE MAKE DECISIONS RELATED TO WATER WITHDRAWALS, LAND USES, STORMWATER AND INFRASTRUCTURE MANAGEMENT, ADAPTATION, AND MITIGATION IN URBAN, SUBURBAN, RURAL, AND NATURAL SYSTEMS. INNOVATIVE SOLUTIONS, SUCH AS TARGETED AQUIFER RECHARGE, COASTAL WETLAND RESTORATION, SALINITY-RESISTANT CROPS, MARSH MIGRATION STRATEGIES, AND ECOSYSTEM SERVICE INCENTIVES, WILL BE PROPOSED AND DEVELOPED TO MITIGATE THE IMPACTS OF SALTWATER INTRUSION. THE PROJECT WILL SUPPORT AND MENTOR SIX EARLY-CAREER FACULTY, TWO POST-DOCTORAL RESEARCHERS, 36 GRADUATE STUDENTS, AND AT LEAST 40 UNDERGRADUATE STUDENTS, ENGAGING THEM IN PROFESSIONAL DEVELOPMENT COHORTS ACROSS INSTITUTIONS TO BUILD WORKFORCE SKILLS, TEAM SCIENCE, COMMUNICATION, AND PROBLEM-SOLVING. OUTCOMES OF THIS RESEARCH WILL PROVIDE A ROBUST SCIENTIFIC FOUNDATION FOR THE DEVELOPMENT OF ADAPTIVE WATER MANAGEMENT STRATEGIES TO ENHANCE THE RESILIENCE OF DELAWARE'S COASTAL COMMUNITIES AND ECOSYSTEMS IN THE FACE OF INCREASING WATER DEMAND AND COMPLEX ENVIRONMENTAL CONDITIONS. THIS PROJECT IS SUPPORTED BY THE EPSCOR RESEARCH INFRASTRUCTURE IMPROVEMENT PROGRAM: EPSCOR RESEARCH INCUBATORS FOR STEM EXCELLENCE (E-RISE). E-RISE SUPPORTS THE DEVELOPMENT OF SUSTAINABLE RESEARCH INFRASTRUCTURE AND CAPACITY IN EPSCOR JURISDICTIONS THROUGH COLLABORATIVE, HYPOTHESIS-DRIVEN, OR PROBLEM-DRIVEN RESEARCH AND WORKFORCE DEVELOPMENT TO IMPROVE COMPETITIVENESS IN SELECTED STEM FIELDS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

COBRE ON MEMBRANE PROTEIN PRODUCTION AND CHARACTERIZATION

UD ADVANCE PROVOST'S INSTITUTE: W2L (WOMEN FACULTY TO LEADERSHIP)

EXAMINING THE EFFICACY OF A FRACTION SENSE INTERVENTION GROUNDED IN PRINCIPLES FROM THE SCIENCE OF LEARNING

EDUCATION RESEARCH PROGRAM

PT/PHD PREDOCTORAL TRAINING PROGRAM

EDUCATION RESEARCH PROGRAM

PURPOSE: THE NATIONAL SEA GRANT COLLEGE PROGRAM WAS ESTABLISHED BY THE U.S. CONGRESS IN 1966 (AMENDED IN 2008, PUBLIC LAW 110-394) TO BE A HIGHLY LEVERAGED FEDERAL AND STATE PARTNERSHIP TO HARNESS THE INTELLECTUAL CAPACITY OF THE NATION'S UNIVERSITIES AND RESEARCH INSTITUTIONS TO SOLVE PROBLEMS AND GENERATE OPPORTUNITIES IN COASTAL COMMUNITIES. FOR OVER 50 YEARS, THE NATIONAL SEA GRANT COLLEGE PROGRAM HAS SUPPORTED COASTAL AND GREAT LAKES COMMUNITIES THROUGH RESEARCH, EXTENSION AND EDUCATION. SEA GRANT'S MISSION IS TO ENHANCE THE PRACTICAL USE AND CONSERVATION OF COASTAL, MARINE AND GREAT LAKES RESOURCES IN ORDER TO CREATE A SUSTAINABLE ECONOMY AND ENVIRONMENT. THIS GRANT IS THE VEHICLE THROUGH WHICH DELAWARE SEA GRANT LAYS OUT ITS PLAN TO IMPLEMENT THE GOALS LAID OUT IN IN THEIR FY2018-23 STRATEGIC PLAN, WHICH CAN BE FOUND AT: HTTPS://SEAGRANT.NOAA.GOV/INSIDESEAGRANT/PLANNING IN ADDITION TO REQUIRED GRANT PROGRESS REPORTING, THE RECIPIENT WILL REPORT DEFINED MEASURES AND METRICS AS

HEALTH CONSEQUENCES OF FEAR OF CANCER RECURRENCE IN BREAST CANCER SURVIVORS AND PARTNERS

UNIVERSITY OF DELAWARE: NEW AWARD. CONTROL NUMBER: 1564-1516 TITLE: ''SIMULTANEOUS OPTIMIZATION OF VEHICLE AND POWERTRAIN OPERATION USING CONNECTIVITY AND AUTOMATION''

BEHAVIORAL AND NEUROPHYSIOLOGIC PROCESSES OF LOCOMOTOR LEARNING AFTER STROKE

CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING

EARLY INTERVENTION FOR CHILDREN ADOPTED INTERNATIONALLY

RECASTING AND BOOK READING UNDER IDEAL (DOSE-CONTROLLED) AND TYPICAL (DOSE-VARIABLE) CONDITIONS: THE ROLE OF FIDELITY AND ADHERENCE IN PRODUCTION AND COMPREHENSION OUTCOMES FOR CHILDREN WITH DLD

EARLY READING FIRST

BEHAVIORAL- AND BIO-MARKERS OF SUBCONCUSSION WITH CONTROLLED HUMAN HEAD IMPACT

CARDIOVASCULAR CONSEQUENCES OF DUCHENNE AND BECKER MUSCULAR DYSTROPHINOPATHIES - ABSTRACT/PROJECT SUMMARY DUCHENNE AND BECKER MUSCULAR DYSTROPHINOPATHIES (DMD/BMD) HAVE A MUTATION IN THE DYSTROPHIN GENE THAT, TOGETHER, REPRESENT OVER 80% OF ALL CASES OF MUSCULAR DYSTROPHY. HISTORICALLY, RESPIRATORY FAILURE WAS THE MAJOR CAUSE OF MORBIDITY AND MORTALITY BUT RECENT TREATMENT ADVANCES HAVE CHANGED THE PROGNOSIS, WITH DILATED CARDIOMYOPATHY AND THE RESULTING HEART FAILURE NOW BEING THE LEADING CAUSE OF DEATH. CURRENTLY, THERE IS NO CONSENSUS ON PREDICTORS OF CARDIAC DISEASE TRAJECTORY, WHEN TO START TREATMENT WITH CARDIAC MEDICATIONS, OR THE MOST APPROPRIATE OUTCOME MEASURES TO EVALUATE THE IMPACT OF THERAPIES ON THE HEART IN PATIENTS WITH DMD AND BMD. THE LONG-TERM GOAL IS TO REDUCE THE INCIDENCE AND DELAY THE PROGRESSION OF DILATED CARDIOMYOPATHY/HEART FAILURE IN CHILDREN WITH DMD AND BMD. THE OBJECTIVE OF THIS STUDY IS TO DETERMINE THE EFFECTS OF DMD AND BMD ON PERIPHERAL VASCULAR FUNCTION AND PULSATILE LOAD ON THE LEFT VENTRICLE (LV), AND TO DETERMINE IF THESE VARIABLES CAN PREDICT CARDIAC FUNCTION. THE CENTRAL HYPOTHESIS IS THAT BOTH DMD AND BMD PATIENTS WILL EXHIBIT DETRIMENTAL CHANGES IN THEIR PERIPHERAL VASCULAR HEALTH AND PULSATILE LOAD ON THE LV WHICH WILL RELATE TO THEIR CARDIAC FUNCTION. THIS HYPOTHESIS IS BASED ON NOVEL PRELIMINARY DATA SHOWING AN ATTENUATION IN PERIPHERAL VASCULAR FUNCTION AND AUGMENTED CENTRAL PRESSURES AND WAVE REFLECTIONS, SUGGESTIVE OF INCREASED PULSATILE LOAD, IN BOTH DMD AND BMD PATIENTS. THE CENTRAL HYPOTHESIS WILL BE TESTED BY PURSUING THREE SPECIFIC AIMS: 1) DETERMINE THE EFFECTS OF DMD AND BMD ON PERIPHERAL VASCULAR FUNCTION; 2) DETERMINE THE EFFECTS OF DMD AND BMD ON PULSATILE LOAD ON THE LV; AND 3) DETERMINE IF PERIPHERAL VASCULAR FUNCTION AND PULSATILE LOAD ON THE LV CAN HELP PREDICT CARDIAC FUNCTION IN PATIENTS WITH DMD AND BMD. UNDER THE FIRST AIM PERIPHERAL VASCULAR FUNCTION WILL BE ASSESSED USING BOTH A CROSS-SECTIONAL (BASELINE) AND LONGITUDINAL DESIGN (12 & 24 MONTHS) IN COHORTS OF DMD AND BMD PATIENTS AND TYPICALLY-DEVELOPING CHILDREN. FOR THE SECOND AIM, PULSATILE LOAD ON THE LV WILL BE EVALUATED BY ASSESSING REFLECTION MAGNITUDE, FORWARD WAVE AMPLITUDE, AORTIC CHARACTERISTIC IMPEDANCE, AND ARTERIAL STIFFNESS IN THE SAME DESIGN AND PARTICIPANTS AS STUDY AIM 1. FINALLY, THE THIRD AIM WILL USE MEASURES OF PERIPHERAL VASCULAR FUNCTION AND PULSATILE LOAD TO EVALUATE PREDICTORS OF CARDIAC FUNCTION MEASURED BY ECHOCARDIOGRAPHY. THE RESEARCH PROPOSED IN THIS APPLICATION IS INNOVATIVE BECAUSE IT REPRESENTS THE INITIAL ATTEMPTS AT DETERMINING PERIPHERAL VASCULAR FUNCTION AND PULSATILE LOAD ON THE LV IN DMD AND BMD PATIENTS WHICH IS THE LOGICAL NEXT STEP TO PREVIOUS ANIMAL STUDIES. ADDITIONALLY, THE STUDY USES NOVEL, STATE-OF-THE-ART NON-INVASIVE METHODOLOGY THAT HAS THE POTENTIAL TO BE INTEGRATED INTO REGULAR CLINICAL PRACTICE TO BETTER DIAGNOSE AND POSSIBLY PREDICT CARDIOMYOPATHY DEVELOPMENT THROUGHOUT DMD AND BMD DISEASE PROGRESSION. THE PROPOSED RESEARCH IS SIGNIFICANT BECAUSE IT WILL INFORM FUTURE INTERVENTIONAL STUDIES, INCLUDING CLINICAL TRIALS THAT WILL ULTIMATELY ALTER THE TRAJECTORY OF CARE FOR THE YOUNG PATIENTS STRUGGLING WITH DMD AND BMD-RELATED CARDIOMYOPATHY.

INTERVENING WITH OPIOID-DEPENDENT MOTHERS LIVING IN POVERTY: EFFECTS ON MOTHERS' AND INFANTS' BEHAVIORAL AND BIOLOGICAL REGULATION

COGNITIVE AND BIOLOGICAL MECHANISMS IN PEDIATRIC VOICE THERAPY

COLLABORATIVE RESEARCH: E-CORE RII: STRENGTHENING PARTNERSHIPS FOR ADVANCING RESEARCH CAPACITY IN DELAWARE -THIS COLLABORATIVE PROJECT IS LED BY THE UNIVERSITY DELAWARE. THE PROJECT'S VISION IS TO CREATE AN INCLUSIVE, OPEN, COLLABORATIVE RESEARCH ECOSYSTEM WHERE FACULTY AND STUDENTS ARE SUPPORTED AND ENCOURAGED TO EXPAND THEIR INTERESTS. A HIGHLY SKILLED WORKFORCE WILL BE EXPANDED AND RETAINED, AND RESEARCH INNOVATION AND INTERCONNECTEDNESS WILL BE INCREASED ACROSS ALL STATE PRIORITY SECTORS. THE PROJECT HAS POTENTIAL TO FOSTER NEW COLLABORATIONS ACROSS INSTITUTIONS IN DELAWARE. ADDITIONALLY, THROUGH ITS FOCUS ON STRENGTHENING THE STATE'S RESEARCH INFRASTRUCTURE, THE PROJECT HAS POTENTIAL TO STRENGTHEN THE STATE'S DATA AND INTELLECTUAL PROPERTY INFRASTRUCTURE, IMPROVE COMMUNICATION AND ACCESS TO STEM PROGRAMMING, AND SUPPORT ENTREPRENEURIAL TRAINING. BY ADDRESSING THESE NEEDS, THIS PROJECT HAS POTENTIAL TO BOOST CUTTING-EDGE RESEARCH CARRIED OUT BY INTERDISCIPLINARY TEAMS, RESULTING IN SUBSTANTIAL GAINS IN DELAWARE'S KNOWLEDGE-BASED ECONOMY. THIS COLLABORATIVE PROJECT IS LED BY THE UNIVERSITY DELAWARE IN PARTNERSHIP WITH THE DELAWARE EPSCOR STATE COMMITTEE, DELAWARE STATE UNIVERSITY, DELAWARE TECHNICAL COMMUNITY COLLEGE, GOLDEY-BEACOM COLLEGE AND WILMINGTON UNIVERSITY. THE PROJECT GOALS ARE TO FORM LASTING NETWORKS THAT FACILITATE ACCESS TO EXPERTISE, SPECIALIZED EQUIPMENT AND RESOURCES, AND SUPPORT FOR MEANINGFUL EXPERIENTIAL-ENTREPRENEURIAL LEARNING OPPORTUNITIES. TO ACHIEVE THIS, THE PROJECT WILL INVEST IN THREE SPECIALIZED CORES, ALONG WITH AN ADMINISTRATIVE CORE. THE PROJECT WILL SUPPORT A RESEARCH SUPPORT CORE TO PROVIDE HIGH-QUALITY RESEARCH TRANSLATION, STRENGTHEN DATA INFRASTRUCTURE, CONNECTIVITY, AND NETWORKING CAPABILITIES THROUGH STRATEGIC INVESTMENTS IN CYBER, HUMAN, AND PHYSICAL INFRASTRUCTURE. THE STEM PATHWAYS K-16 CORE AIMS TO STRENGTHEN AND BROADEN PARTICIPATION IN DELAWARE'S STEM PIPELINE AND RELATED PATHWAYS. THE WORKFORCE DEVELOPMENT CORE WILL FOCUS ON STRENGTHENING SKILLS AND BROADENING PARTICIPATION IN STEM THROUGH INVESTMENTS IN TEAM BUILDING, RESEARCH COLLABORATION, AND CONNECTIVITY TO MEET THE NEEDS OF EMPLOYERS IN THE STATE'S PRIORITY AREAS. IN ADDITION, AN ADMINISTRATIVE CORE WILL SUPPORT OVERALL COHESION, FACILITATE RESEARCH AND INFRASTRUCTURE COLLABORATIONS, COMMUNICATE OPPORTUNITIES AND ENHANCE AND SUSTAIN JURISDICTION-WIDE RESEARCH ADMINISTRATION. THESE INVESTMENTS WILL MAKE DELAWARE AN IDEAL TESTBED TO IMPLEMENT E-CORE'S MISSION TO PROMOTE SUSTAINABLE IMPROVEMENTS IN THE RESEARCH INFRASTRUCTURE AND R&D CAPACITY AND COMPETITIVENESS. THIS PROJECT IS SUPPORTED BY THE EPSCOR RESEARCH INFRASTRUCTURE IMPROVEMENT PROGRAM: EPSCOR COLLABORATIONS FOR OPTIMIZING RESEARCH ECOSYSTEMS (E-CORE). E-CORE SUPPORTS JURISDICTIONS IN STRENGTHENING THEIR JURISDICTION-WIDE RESEARCH ECOSYSTEMS THROUGH FOSTERING INTERCONNECTED NETWORKS, BUILDING RESEARCH INFRASTRUCTURE, AND GROWING RESEARCH CAPACITY AND COMPETITIVENESS ALIGNED WITH JURISDICTIONAL PRIORITIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

NEURAL SUBTYPES OF DEVELOPMENTAL STUTTERING - PROJECT SUMMARY/ABSTRACT WHILE THE BEHAVIORAL HETEROGENEITY OF STUTTERING HAS BEEN LONG RECOGNIZED, VERY LITTLE IS KNOWN ABOUT MECHANISMS UNDERLYING THE HETEROGENEITY. WITHOUT THIS KNOWLEDGE, THE COMPLEX ETIOLOGY OF STUTTERING CANNOT BE FULLY UNDERSTOOD, AND THE DEVELOPMENT OF INDIVIDUALIZED TREATMENT APPROACHES WILL CONTINUE TO BE SEVERELY HINDERED. OUR LONG-TERM GOAL IS TO DEVELOP NEUROSCIENCE-BASED TREATMENT APPROACHES FOR DEVELOPMENTAL STUTTERING. IN PURSUIT OF THIS GOAL, THE OBJECTIVE OF THE PRESENT APPLICATION IS TO IDENTIFY SUBTYPES OF CHILDREN WHO STUTTER (CWS) BASED ON NEUROANATOMICAL ANOMALIES AND CHARACTERIZE EACH SUBTYPE’S BEHAVIORAL PROFILES AND BRAIN ACTIVITY DURING SPEECH PRODUCTION. THE CENTRAL HYPOTHESIS IS THAT EACH NEURAL SUBTYPE IS ASSOCIATED WITH BEHAVIORAL AND BRAIN ACTIVITY CHANGES CONSISTENT WITH ITS PRIMARY NEUROANATOMICAL ANOMALIES. THE RATIONALE OF THIS PROPOSED PROJECT IS THAT ELUCIDATING THE NEURAL SUBTYPES OF STUTTERING WILL HELP US UNDERSTAND THE HETEROGENEITY AND NEUROLOGICAL ETIOLOGIES OF THE DISORDER, WHICH IS AN IMPORTANT BASIS FOR DEVELOPING NEW TREATMENT APPROACHES THAT TARGET INDIVIDUAL NEUROLOGICAL DEFICITS. WE WILL TEST OUR CENTRAL HYPOTHESIS BY PURSUING THREE SPECIFIC AIMS. I) IDENTIFY SUBTYPES OF CWS BASED UPON PATTERNS OF NEUROANATOMICAL ANOMALIES. TO ACHIEVE THIS AIM, WE WILL USE A CLUSTERING METHOD TO ANALYZE GRAY MATTER VOLUME PATTERNS IN CWS. WE HYPOTHESIZE THAT CWS COMPRISE NEURAL SUBTYPES, CHARACTERIZED BY PRIMARY STRUCTURAL ANOMALIES IN THE PREFRONTAL AREAS, THE BASAL GANGLIA THALAMOCORTICAL CIRCUIT AND THE CEREBELLUM. II) CHARACTERIZE BEHAVIORAL PROFILES ASSOCIATED WITH EACH NEURAL SUBTYPE. BASED ON CONTEMPORARY MODELS OF SPEECH MOTOR CONTROL, WE HYPOTHESIZE THAT EACH NEURAL SUBTYPE WILL DIFFER IN BOTH STUTTERING BEHAVIORS, LANGUAGE ABILITY, AND SPEECH MOTOR PERFORMANCE DEPENDING ON THE FUNCTIONS OF ITS PRIMARY NEUROANATOMICAL ANOMALY LOCI. III) CHARACTERIZE BRAIN ACTIVITY ASSOCIATED WITH SPEECH PRODUCTION IN EACH NEURAL SUBTYPE. TO ACHIEVE THIS AIM, WE WILL IDENTIFY DIFFERENCES IN BRAIN ACTIVITY BETWEEN NEURAL SUBTYPES DURING OVERT CONTINUOUS SPEECH USING FUNCTIONAL MAGNETIC RESONANCE IMAGING. OUR WORKING HYPOTHESIS IS THAT COMPARED TO CONTROLS, EACH NEURAL SUBTYPE OF CWS WILL EXHIBIT REDUCED ACTIVATION ASSOCIATED WITH ITS PRIMARY ANATOMICAL ANOMALIES AS WELL AS THEIR COMMON INPUT REGION, THE LEFT PREMOTOR AREAS. UPON SUCCESSFUL COMPLETION OF THE PROPOSED RESEARCH, WE EXPECT TO GAIN AN EXPANDED UNDERSTANDING OF ANATOMICAL NEURAL SUBTYPES OF STUTTERING, AND FOR THE FIRST TIME, LINK BEHAVIORS AND BRAIN ACTIVITY DIFFERENCES DURING SPEECH PRODUCTION AMONG THE DIFFERENT SUBTYPES. BETTER CHARACTERIZING NEURAL SUBTYPES OF STUTTERING WOULD SUBSTANTIALLY CONTRIBUTE TO OUR UNDERSTANDING OF THE HETEROGENEITY OF STUTTERING, WHICH IS AN IMPORTANT STEP IN ELUCIDATING THE DISORDER’S COMPLEX ETIOLOGY.

CENTER FOR SPINTRONICS AND BIODETECTION

ROBOTIC EXOSKELETONS, FES, AND BIOMECHANICS: TREATING MOVEMENT DISORDERS

PURPOSE: CREATE THE UNIVERSITY OF DELAWARE (UD) PROCESS DEVELOPMENT TESTBED WITH RELEVANT EQUIPMENT TO FACILITATE PROCESS IMPROVEMENTS, WORKFORCE DEVELOPMENT, AND THE TESTING AND DEMONSTRATION OF BIOPHARMACEUTICAL INNOVATIONS. THIS FACILITY WILL LEVERAGE THE KNOWLEDGE AND EXPERIENCE OF THE NIIMBL, A PUBLIC-PRIVATE PARTNERSHIP FOCUSED ON THE ACCELERATION OF THE BIOPHARMACEUTICAL INNOVATION. ACTIVITIES TO BE PERFORMED: THIS PROJECT WILL PROCURE AND INSTALL EQUIPMENT FOR UD PROCESS DEVELOPMENT TESTBED THAT WILL SERVE AS A SCALE-DOWN MODEL OF THE NIIMBL PROCESS INTENSIFICATION TESTBED. PHASE 1 WILL INCLUDE FINALIZING DETAILS, SPECIFICATIONS, AND RECEIVE NECESSARY QUOTATIONS FOR EQUIPMENT. IN PHASE 2, THEY WILL PROCURE AND INSTALL EQUIPMENT, AND PERFORM SITE ACCEPTANCE TESTING.EXPECTED OUTCOMES: THE UD PROCESS DEVELOPMENT TESTBED WILL ALLOW SMALLER SCALE, MORE RAPID, AND MORE AFFORDABLE BIOPHARMACEUTICAL EXPERIMENTS TO BE PERFORMED. THE TESTBED WILL ENABLE WORKFORCE DEVELOPMENT AND TRAINING, DATA TO BE COLLECTED AND USED IN PROCESS MODELS BEING DEVELOPED IN THE NIIMBL BIG DATA PROGRAM, AND NEW MATERIALS (HARVEST CELL CULTURE FLUID, CHROMATOGRAPHY ELUATES, ETC.) PRODUCED THAT CAN BE SHARED WITH THE BIOPHARMACEUTICAL MANUFACTURING INNOVATION COMMUNITY. INTENDED BENEFICIARIES:1. TO NIST: THE WORK PLANS ALIGN WITH NIST'S MANUFACTURING MISSION SPACE FOR BOTH ADVANCED MANUFACTURING TECHNOLOGY AND SUPPLY CHAIN SECURITY. NIST STAFF CAN LEVERAGE THIS PROJECT TO FURTHER THE IMPACT OF OUR TECHNICAL EXPERTISE IN BIOMANUFACTURING, SPECIFICALLY THE ONGOING DEVELOPMENT OF THE RESEARCH GRADE REFERENCE CELL-LINE EXPRESSING THE NIST-MAB TO FOSTER INNOVATION BIOPHARMACEUTICAL MANUFACTURING. THE PROJECT ALSO LEVERAGES NIST'S INVESTMENT IN NIIMBL. 2. TO AWARDEE: THE UNIVERSITY OF DELAWARE, AS THE LEAD OF THE NIIMBL CONSORTIUM, WILL BE ABLE TO ESTABLISH A MORE COST-EFFICIENT CAPABILITY TO DO SMALL SCALE BIOPHARMA PROCESS-DEVELOPMENT WORK ON INDUSTRIALLY RELEVANT EQUIPMENT TO PREPARE FOR RUNS OF THE NIIMBL PROCESS INTENSIFICATION TEST BED. 3. TO THE NATION: THE PANDEMIC HAS FULLY REVEALED THE IMPORTANCE OF AN AGILE DOMESTIC CAPACITY FOR PRODUCTION OF BIOMANUFACTURED THERAPIES SUCH AS VACCINES. THE UNIVERSITY OF DELAWARE'S LEADERSHIP OF THE NIIMBL PARTNERSHIP SUPPORTS THE COLLABORATIVE DEVELOPMENT OF THE NEXT GENERATION PROCESSES FOR MANUFACTURING THESE CRITICAL PRODUCTS. THIS FUNDING WILL ENABLE NIIMBL TO PROVIDE AN OPEN COLLABORATION RESOURCE FOR THE US BIOECONOMY THAT WILL AID IN DEVELOPING NEW TECHNOLOGIES TO SUPPORT FASTER TO MARKET, HIGHER QUALITY AND EXTENDED SUPPLY AND AVAILABILITY OF DRUG PRODUCTS. SUBRECIPIENT ACTIVITIES:NO SUBRECIPIENT ACTIVITIES WILL BE INVOLVED WITH THIS GRANT.

FMRG: ECO: A SYSTEMS-ENABLED PARADIGM SHIFT FOR MODULAR SUSTAINABLE CHEMICAL MANUFACTURING

IGERT: SYSTEMS BIOLOGY OF CELLS IN ENGINEERED ENVIRONMENTS (SBE2)

SENSABLE, MANAGEABLE, ADAPTABLE, REUSABLE TOOLING (SMARTOOLING) FOR LIGHTWEIGHT COMPOSITE AUTOMOTIVE COMPONENTS

NRT- HDR: COMPUTING AND DATA SCIENCE TRAINING FOR MATERIALS INNOVATION, DISCOVERY, ANALYTICS

TENSOR APPROACHES FOR SIMULATING KINETIC SYSTEMS

NEW: TITLE: EXPERIMENTAL SYSTEMS-BIOLOGY APPROACHES FOR CLOSTRIDIA-BASED BIOENERGY PRODUCTION; PI: ELEFTHERIOS PAPOUTSAKIS

DEVELOPMENT OF THE ORIENTING POSITIVE EMOTIONS IN NEW EDUCATORS FOR MATHEMATICS (OPEN FOR MATH) PROFESSIONAL LEARNING PROGRAM -THE SOCIAL AND EMOTIONAL ASPECTS OF A CLASSROOM CLIMATE ARE ESSENTIAL TO CREATING A SPACE CONDUCIVE TO LEARNING. RESEARCH HAS SHOWN THAT THE EMOTIONS ELEMENTARY SCHOOL TEACHERS AND THEIR STUDENTS EXPERIENCE WHEN ENGAGING IN MATHEMATICS ACTIVITIES PLAY AN IMPORTANT ROLE IN MATHEMATICS TEACHING AND LEARNING. IF TEACHERS OR THEIR STUDENTS REGULARLY EXPERIENCE NEGATIVE EMOTIONS SUCH AS ANXIETY AND ANGER WHEN WORKING ON MATHEMATICS ACTIVITIES, THEN THE QUALITY OF TEACHING AND LEARNER ENGAGEMENT IN THE MATHEMATICS MAY BE NEGATIVELY IMPACTED. IF TEACHERS OR THEIR STUDENTS ENGAGE IN MINDFULNESS AND EMOTIONAL REGULATION AND CAN EXPERIENCE MORE POSITIVE EMOTIONS WHEN ENGAGING IN MATHEMATICS ACTIVITIES, THEN THE QUALITY OF TEACHING AND LEARNER ENGAGEMENT IN THE MATHEMATICS CAN BE POSITIVELY IMPACTED. YET, THE FIELD LACKS MATHEMATICS-SPECIFIC PROFESSIONAL LEARNING OPPORTUNITIES FOR ELEMENTARY TEACHERS THAT FOCUS ON THE ROLE OF TEACHERS? AND LEARNERS? EMOTIONS IN THE WAY THEY EXPERIENCE MATHEMATICS IN THE CLASSROOM. PROFESSIONAL LEARNING OPPORTUNITIES HAVE ALSO NOT FOCUSED ON THE UNIQUE NEEDS AND EXPERIENCES OF FIRST-YEAR EDUCATORS. THIS PROJECT WILL ADDRESS THESE GAPS BY DEVELOPING AND TESTING THE ORIENTING POSITIVE EMOTIONS IN NEW TEACHERS FOR MATHEMATICS (OPEN FOR MATH) PROFESSIONAL LEARNING PROGRAM. OPEN FOR MATH PROFESSIONAL LEARNING PROGRAM WILL SUPPORT BEGINNING ELEMENTARY EDUCATORS? ABILITY TO CREATE AN EQUITABLE AND POSITIVE MATHEMATICS CLASSROOM IN WHICH TEACHERS LEVERAGE THE EMOTIONS THEY AND THEIR STUDENTS? EXPERIENCE WHEN ENGAGING IN MATHEMATICS ACTIVITIES TO FACILITATE STUDENTS? POSITIVE MATHEMATICS ENGAGEMENT AND ACHIEVEMENT. THIS PROJECT WILL SERVE TO INCREASE THE FIELD?S CAPACITY TO IMPROVE ELEMENTARY MATHEMATICS TEACHERS? EFFECTIVENESS AND RETENTION VIA MORE EMOTIONALLY RESPONSIVE TEACHER PROFESSIONAL LEARNING AND MAY REDUCE THE MATHEMATICS ACHIEVEMENT GAPS CURRENTLY OBSERVED BETWEEN UNDER-SERVED AND ADEQUATELY SERVED U.S. STUDENTS. THIS TEACHING STRAND, DESIGN AND DEVELOPMENT (EARLY STAGE), LEVEL 2 PROJECT AT THE UNIVERSITY OF DELAWARE WILL BE CARRIED OUT IN PARTNERSHIP WITH DISTRICT AND SCHOOL LEADERS AND EDUCATORS FROM FIVE PUBLIC SCHOOL DISTRICTS IN THE STATE OF DELAWARE. THE RESEARCH TEAM WILL WORK IN COLLABORATION WITH INSTRUCTIONAL DESIGNERS, SCHOOL LEADERS, AND IN-SERVICE EDUCATORS TO DEVELOP AN INITIAL VERSION OF OPEN FOR MATH CONTENT AND A DELIVERY PLAN THAT IS RESPONSIVE TO THE NEEDS AND EXPERIENCES OF THE PROJECT?S FOCAL AUDIENCES. IN THE INITIAL STAGES OF THIS PROJECT, THE RESEARCH TEAM WILL COLLABORATE WITH DISTRICT AND SCHOOL LEADERS TO ASSESS POTENTIAL IMPLEMENTATION BARRIERS AND SUPPORTS TO IMPLEMENTING THE OPEN FOR MATH PROFESSIONAL LEARNING PROGRAM. IN THE LATTER STAGES OF THIS PROJECT, THE RESEARCH TEAM WILL CONDUCT TWO CONSECUTIVE YEAR-LONG PILOT TRIALS OF OPEN FOR MATH WITH FIRST-YEAR EDUCATORS IN PARTNERING DISTRICTS, RECRUITING APPROXIMATELY 90 FIRST YEAR TEACHERS. OPEN FOR MATH CONTENT AND DELIVERY STRATEGIES WILL BE REVISED BASED ON DETAILED USER FEEDBACK COLLECTED THROUGHOUT EACH PILOT TRIAL. THE RESEARCH TEAM WILL COLLECT A COMBINATION OF SURVEY, INTERVIEW, AND CLASSROOM OBSERVATION DATA FROM AMONG PILOT PARTICIPANTS TO PERFORM MIXED-METHODS ANALYSES THAT WILL SPEAK TO THE POTENTIAL EFFICACY OF OPEN FOR MATH IN IMPROVING TARGET TEACHER-AND CLASSROOM-LEVEL OUTCOMES. THE RESEARCH TEAM WILL ANALYZE DATA TO BETTER UNDERSTAND WHICH FEATURES OF OPEN FOR MATH TEACHERS USE WHEN TEACHING AND ARE RESPONSIVE TO THE NEEDS OF BEGINNING TEACHERS. THE WORK WILL ALSO INVESTIGATE THE EXTENT TO WHICH TEACHERS? EMOTIONS WHEN ENGAGING WITH MATHEMATICAL ACTIVITIES AND THEIR MATHEMATICAL INSTRUCTIONAL PRACTICES CHANGE, HOW THEIR PERSONAL CHARACTERISTICS INFLUENCE THEIR RESPONSE TO THE PROGRAM AND HOW OPEN FOR MATH COULD BE SUCCESSFULLY APPLIED IN DIFFERENT CONTEXTS. LASTLY, A RETROACTIVE IMPLEMENTATION EVALUATION WILL BE CARRIED OUT TO INFORM FUTURE ADAPTATION AND SCALING OF THE PROGRAM. THE DISCOVERY RESEARCH PREK-12 PROGRAM (DRK-12) SEEKS TO SIGNIFICANTLY ENHANCE THE LEARNING AND TEACHING OF SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) BY PREK-12 STUDENTS AND TEACHERS, THROUGH RESEARCH AND DEVELOPMENT OF INNOVATIVE RESOURCES, MODELS, AND TOOLS. PROJECTS IN THE DRK-12 PROGRAM BUILD ON FUNDAMENTAL RESEARCH IN STEM EDUCATION AND PRIOR RESEARCH AND DEVELOPMENT EFFORTS THAT PROVIDE THEORETICAL AND EMPIRICAL JUSTIFICATION FOR PROPOSED PROJECTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

HAZARDS SEES TYPE 2: DYNAMIC INTEGRATION OF NATURAL, HUMAN, AND INFRASTRUCTURE SYSTEMS FOR HURRICANE EVACUATION AND SHELTERING

HARNESSING ALKYL AMINES AND ALKYL ALCOHOLS IN CROSS-COUPLING REACTIONS

NEURAL ENCODING OF SOCIAL INFORMATION

IMPROVING PROFESSIONAL DEVELOPMENT IN MATHEMATICS BY UNDERSTANDING THE MECHANISMS THAT TRANSLATE TEACHER LEARNING INTO STUDENT LEARNING

NATIONAL CENTER FOR EDUCATION RESEARCH

ADAPTIVE AND MALADAPTIVE NEURAL NETWORK RESPONSES TO INHIBITORY CHALLENGES

MENTAL HEALTH SERVICES FOR TODDLERS IN FOSTER CARE

BIOMECHANICAL ENGINEERING OF FIBROUS LOAD-BEARING TISSUE

CENTER FOR SPINTRONICS AND BIODETECTION

UNIVERSITY CENTER FOR EXCELLENCE IN DEVELOPMENTAL DISABILITIES

AFRICAN AMERICAN FAMILIES FIGHTING PARENTAL CANCER TOGETHER

DEDICATED BEAMLINE FACILITIES FOR CATALYTIC RESEARCH

SCHOOL-BASED MENTAL HEALTH PROMOTION IN THE FIRST STATE: BUILDING CAPACITY WITH MULTI-TIERED SYSTEMS OF SUPPORT

CHEMISTRY AND BIOLOGY INTERFACE (CBI) NIH T32 TRAINING GRANT

MECHANISMS UNDERLYING THE PROTECTIVE VASCULAR EFFECTS OF DIETARY POTASSIUM IN HUMANS

THE GUIDING PRINCIPLES OF THE DELAWARE SPACE GRANT COLLEGE (DESGC) PROGRAM ARE AS FOLLOWS: REASON FOR DESGC'S EXISTENCE: TO SERVE THE STUDENTS AND RE

HIGH-RESOLUTION, ANISOTROPIC MR ELASTOGRAPHY OF THE BRAIN

THIS PROJECT INTEGRATES SEVEN TASKS THAT LEVERAGE EXISTING CAPACITY TO ADDRESS AGING INFRASTRUCTURE AND PROTECT VALUABLE RESOURCES. TASK 1 WILL REPLACE AGING COMPONENTS OF THE HIGH FREQUENCY RADAR OBSERVING SYSTEM. THE BENEFITS OF THIS WORK WILL INCREASE THE COVERAGE AND DATA QUALITY OF THE SURFACE CURRENT MEASUREMENTS IN THE REGION. THE US COAST GUARD USES THE SURFACE CURRENTS OPERATIONALLY FOR SEARCH AND RESCUE AND NOAA OFFICE OF RESPONSE AND RESTORATION FOR OIL SPILL RESPONSE AND THIS WILL ENHANCE THEIR CAPABILITIES. TASK 2 WILL ADDRESS CREATING A MULTI-SENSOR STREET COASTAL FLOOD OBSERVATION TESTBED TO FOCUS ON THE MOST HIGHLY POPULATED PART OF THE MARACOOS REGION, THE NEW YORK CITY METROPOLITAN AREA THAT IS AFFECTED MORE FREQUENTLY BY FLOODING. THIS PROJECT WILL HELP INNOVATE ON-STREET MEASUREMENTS OF FLOODING AND THE DEVELOPMENT OF MODELS THAT CAN HELP PREDICT NEIGHBORHOOD FLOODING ALONG OUR COASTS, INCLUDING IN UNDERSERVED AND UNDERREPRESENTED COMMUNITIES. TASK 3 WILL ADDRESS DEVELOPING USER DRIVEN PRODUCTS THAT WILL PROVIDE SEVERAL UNIQUE DATA PRODUCTS MADE SPECIFICALLY FOR OUR REGIONAL STAKEHOLDERS FROM HFR DATA AND WATER LEVEL / FLOOD OBSERVATION DATA/MODELS COLLECTED AND DEVELOPED THROUGH THE ABOVE-REFERENCED INFRASTRUCTURE, AS WELL AS OTHER CRITICAL DATA SETS COLLECTED OR LEVERAGED BY MARACOOS AND ITS PARTNERS. WE WILL ADVANCE AND REFINE THE TOOLS TO IMPROVE UNDERSTANDING AND USER OPERATIONS SO THAT WE CAN PROVIDE CRITICAL TOOLS NEEDED FOR COMMUNITIES TO UNDERSTAND WHAT IS HAPPENING AND HOW TO ADDRESS CONCERNS. TASK 4 WILL PROVIDE MUCH NEEDED IMPROVEMENTS TO THE GLIDER DAC INCLUDING STABILITY, SECURITY UPDATES, PERFORMANCE MONITORING AND REPORTING ENHANCEMENTS AND USER COMMUNITY NOTIFICATION IMPROVEMENTS ON INFRASTRUCTURE AND SYSTEMS AVAILABILITY.

IDENTIFYING CAUSAL MECHANISMS IN AN EMOTION-BASED PREVENTIVE INTERVENTION

PATHWAYS TO MENTAL HEALTH CARE: EXAMINING THE LONGITUDINAL IMPACT OF STIGMA MECHANISMS ON TREATMENT ENGAGEMENT IN EMERGING ADULTS - PROJECT SUMMARY/ABSTRACT MANY EMERGING ADULTS (AGED 18-25) IN THE U.S. ARE LIVING WITH UNRECOGNIZED AND/OR UNTREATED DEPRESSION AND ANXIETY. EMERGING ADULTS HAVE THE HIGHEST RATES (26%) OF MENTAL ILLNESS (MI) AND LOWEST RATES OF TREATMENT SEEKING (38%), COMPARED TO ALL OTHER AGE GROUPS. UNTREATED DEPRESSION AND ANXIETY ARE PARTICULARLY PREVALENT AMONG EMERGING ADULTS AND ARE KEY RISK FACTORS FOR THE DEVELOPMENT OF SUBSTANCE USE DISORDERS, CARDIOVASCULAR DISEASE, AND CHRONIC HEALTH CONDITIONS LATER IN ADULTHOOD, AS WELL AS PREMATURE DEATH. EFFICACIOUS MI TREATMENTS ARE AVAILABLE, BUT MI STIGMA IS A SUBSTANTIAL BARRIER TO RECOGNIZING AND TREATING DEPRESSION AND ANXIETY. EMERGING ADULTS ARE PARTICULARLY VULNERABLE TO MI STIGMA GIVEN INTENSE COGNITIVE, BIOLOGICAL, AND SOCIAL CHANGES OCCURRING DURING THESE YEARS. ALTHOUGH SCIENTISTS HAVE BEGUN TO ASSEMBLE AND REFINE AN EVIDENCE-BASED STIGMA-REDUCTION TOOLBOX, STIGMA INTERVENTIONS HAVE FALLEN SHORT OF FULLY ADDRESSING MI STIGMA IN PART BECAUSE THEY TAKE A “ONE SIZE FITS ALL” APPROACH. STIGMA INTERVENTIONS MAY BE MORE EFFICACIOUS IF THEY ADDRESS STIGMA MECHANISMS WHEN THEY ARE MOST PRONOUNCED, TARGET THE SPECIFIC STIGMA MECHANISM(S) THAT ARE MOST HARMFUL TO TREATMENT OUTCOMES, AND PROVIDE EXTRA SUPPORT FOR PEOPLE WHO LACK RESILIENCE TO STIGMA. OUR LONG-TERM GOAL IS TO TAILOR MI STIGMA INTERVENTIONS FOR EMERGING ADULTS TO PROMOTE POSITIVE TREATMENT OUTCOMES AND LIFETIME WELLBEING. IN ORDER TO INFORM THE TAILORING OF THESE INTERVENTIONS, WE NEED GREATER UNDERSTANDING OF HOW STIGMA EVOLVES AND IMPACTS TREATMENT OUTCOMES DURING EMERGING ADULTHOOD. THE OBJECTIVE OF THE CURRENT PROPOSAL IS TO EXAMINE LONGITUDINAL RELATIONSHIPS BETWEEN MI STIGMA AND TREATMENT OUTCOMES AMONG A LARGE, NATIONAL SAMPLE OF EMERGING ADULTS. OUR SPECIFIC AIMS ARE TO: (1) CHARACTERIZE TRAJECTORIES OF MI STIGMA MECHANISMS AND IDENTIFY MODERATORS OF TRAJECTORIES AMONG EMERGING ADULTS EXPERIENCING DEPRESSION AND/OR ANXIETY; (2) EXAMINE ASSOCIATIONS BETWEEN MI STIGMA MECHANISMS, MI RECOGNITION AND MI TREATMENT ENGAGEMENT OVER TIME; AND (3) IDENTIFY LATENT PROFILES OF MI STIGMA MECHANISMS, HOW INDIVIDUALS TRANSITION ACROSS PROFILES OVER TIME, AND LINKS BETWEEN PROFILES AND TREATMENT ENGAGEMENT. WE PROPOSE A NATIONAL, LONGITUDINAL STUDY OF EMERGING ADULTS (AGED 18-25), SURVEYING 4000 PARTICIPANTS 4 TIMES A YEAR FOR 3 YEARS REGARDING STIGMA MECHANISMS, MODERATING FACTORS, MENTAL HEALTH, AND TREATMENT ENGAGEMENT. BASED ON EPIDEMIOLOGICAL ESTIMATES, WE PROJECT THAT ~30% (N=1200) OF PARTICIPANTS WILL EXPERIENCE A NEW ONSET OF DEPRESSION OR ANXIETY DURING THE STUDY. DATA WILL BE ANALYZED USING MULTILEVEL MODELING, MODERATION ANALYSES, LATENT PROFILE AND LATENT TRANSITION ANALYSES. FINDINGS WILL ENABLE RESEARCHERS TO BETTER IDENTIFY: (1) THE IDEAL TIMING OF STIGMA INTERVENTIONS TO MAXIMIZE IMPACT AMONG EMERGING ADULTS, (2) WHO AMONG EMERGING ADULTS ARE MOST VULNERABLE TO THE EFFECTS OF STIGMA, (3) WHICH STIGMA MECHANISMS SHOULD BE TARGETED FOR INTERVENTION TO IMPROVE LIFELONG HEALTH AND WELLBEING, AND (4) HOW TO COMBINE STIGMA-REDUCTION TOOLS FOR SUBGROUPS OF EMERGING ADULTS. THIS PROPOSAL RESPONDS TO NIMH AND NICHD’S STRATEGIC OBJECTIVES TO DETERMINE WHEN, WHERE, AND HOW TO INTERVENE TO IMPROVE HEALTHCARE DURING THE TRANSITION TO ADULTHOOD.

DELAWARES UNIVERSITY CENTER FOR EXCELLENCE IN DEVELOPMENTAL DISABILITIES

PAIN AND MOTOR LEARNING IN OLDER ADULTS - PROJECT SUMMARY THE MAJORITY OF OLDER ADULT PATIENTS WHO SEEK PHYSICAL THERAPY HAVE PAIN. PHYSICAL REHABILITATION FOR MANY PAINFUL ORTHOPEDIC AND NEUROLOGIC CONDITIONS OFTEN INVOLVES THE USE OF MOTOR LEARNING STRATEGIES, IN WHICH NEW MOVEMENT PATTERNS ARE TAUGHT USING REPEATED TRIAL-AND-ERROR PRACTICE. HOWEVER, PRELIMINARY DATA FROM OUR LAB SUGGESTS THAT PAIN MAY NEGATIVELY AFFECT THE RETENTION OF NEWLY LEARNED MOTOR PATTERNS. IF CORRECT, THIS WOULD SUGGEST THAT THE PRESENCE OF PAIN MAY LIMIT REHABILITATION OUTCOMES SOUGHT THROUGH MOTOR LEARNING-BASED INTERVENTIONS. TO DATE, THE EFFECTS OF ACUTE OR CHRONIC PAIN ON MOTOR LEARNING HAVE NOT BEEN THOROUGHLY INVESTIGATED IN CLINICAL POPULATIONS. FURTHER, IT IS NOT KNOWN HOW PAIN AFFECTS MOTOR LEARNING IN OLDER ADULTS SPECIFICALLY, DESPITE THE FACT THAT COGNITIVE DECLINES, WHICH ARE WELL-DOCUMENTED IN THE ELDERLY, COULD ALSO NEGATIVELY AFFECT LEARNING AND MOTOR MEMORY. BROADLY, THE PURPOSE OF THIS RESEARCH IS TO INVESTIGATE THE IMPACT OF BOTH ACUTE AND CHRONIC PAIN ON LOCOMOTOR LEARNING AND ITS RETENTION IN YOUNG AND OLDER ADULTS AS WELL AS OLDER ADULTS WITH CHRONIC LOW BACK PAIN. OUR CENTRAL HYPOTHESIS IS THAT BOTH ACUTE AND CHRONIC PAIN IMPAIR RETENTION OF LOCOMOTOR LEARNING AND THAT IN OLDER ADULTS, THESE DEFICITS ARE WORSENED AND ARE RELATED TO THE DEGREE OF COGNITIVE DECLINE. WE WILL INVESTIGATE THIS HYPOTHESIS WITH THREE AIMS: (1) USING OUR EXPERIMENTAL PAIN PARADIGM, TO COMPARE EFFECTS OF ACUTE PAIN ON RETENTION OF LOCOMOTOR LEARNING IN HEALTHY YOUNG AND HEALTHY OLDER ADULTS; (2) TO DETERMINE WHETHER OLDER ADULTS WITH CHRONIC LOW BACK PAIN HAVE IMPAIRED RETENTION OF LOCOMOTOR LEARNING; AND (3) TO ASSESS RELATIONSHIPS BETWEEN CHRONIC PAIN, COGNITION, AND MOTOR LEARNING RETENTION CAPACITY IN OLDER ADULTS. MOTOR LEARNING AND ITS RETENTION WILL BE ASSESSED USING OUR NOVEL VISUALLY- DRIVEN LOCOMOTOR LEARNING PARADIGM. SEVERAL ASPECTS OF COGNITION WILL BE QUANTIFIED WITH A COGNITIVE BATTERY, WITH SPECIAL FOCUS ON ATTENTION AND WORKING MEMORY. FINALLY, PAIN WILL BE QUANTIFIED WITH ASSESSMENTS OF INTENSITY, INTERFERENCE AND SENSITIVITY. RESULTS FROM THIS WORK WILL PROVIDE MUCH NEEDED DATA CONCERNING THE RELATIONSHIP BETWEEN PAIN AND MOTOR LEARNING IN OLDER ADULT CLINICAL POPULATIONS. GIVEN THAT MANY REHABILITATION INTERVENTIONS UTILIZE MOTOR LEARNING-BASED STRATEGIES TO RECOVER NORMAL MOVEMENT PATTERNS, GAINING THIS NEW KNOWLEDGE IS LIKELY TO FUNDAMENTALLY IMPROVE DELIVERY OF REHABILITATION IN MULTIPLE PATIENT POPULATIONS THAT EXPERIENCE PAIN.

UNOLS EAST COAST VAN POOL

BENEFITS AND HARMS OF ANTIHYPERTENSIVE MANAGEMENT STRATEGIES FOR NURSING HOME RESIDENTS WITH ADRD - PROJECT SUMMARY HYPERTENSION (HTN) AFFECTS OVER 90% OF OLDER ADULTS WITH ALZHEIMER'S DISEASE AND RELATED DEMENTIAS (ADRD). RANDOMIZED TRIALS HAVE SHOWN THAT AN INTENSIVE HTN TREATMENT STRATEGY (INCREASING THE DOSE OR ADDING MEDICATIONS WHEN THE SYSTOLIC BLOOD PRESSURE [SBP] IS >130 MMHG) REDUCES THE RISK OF CARDIOVASCULAR EVENTS, MORTALITY, INCIDENT DEMENTIA, AND COGNITIVE DECLINE AMONG HEALTHY OLDER ADULTS. HARMS OF INTENSIVE HTN TREATMENT INCLUDED SYNCOPE, FALL-RELATED INJURIES, ELECTROLYTE ABNORMALITIES, AND ACUTE RENAL INJURY. HOWEVER, TRIALS EXCLUDED PERSONS WITH ADRD AND THOSE RESIDING IN NURSING HOMES (NH). LITTLE DATA EXIST TO PROVIDE DIRECT EVIDENCE ON THE BENEFITS AND HARMS OF AN INTENSIVE HTN TREATMENT STRATEGY FOR OLDER ADULTS WITH ADRD, HALF OF WHOM RESIDE IN NH. INTENSIVE HTN TREATMENT MAY OFFER CRITICAL BENEFITS FOR OLDER ADULTS WITH ADRD, AS THEY ARE AT HIGH RISK OF CV EVENTS AND COGNITIVE DECLINE. CONVERSELY, INTENSIVE HTN TREATMENT MAY CAUSE DISPROPORTIONATE HARMS IN THIS POPULATION BECAUSE OF A HIGH PREVALENCE OF RISK FACTORS FOR FALLS AND ADVERSE EVENTS, LIKE POLYPHARMACY, FRAILTY, AND COGNITIVE IMPAIRMENT. GIVEN THE DIVERSE RANGE OF PATIENTS WITH ADRD RESIDING IN NH, THESE BENEFITS AND HARMS ARE ALSO LIKELY MODIFIED BY CLINICAL (E.G., PRIOR STROKE, HEART FAILURE) AND DEMOGRAPHIC (E.G., SEX) CHARACTERISTICS. EVIDENCE-BASED HTN TREATMENT STRATEGIES ARE NEEDED TO AVOID HARMS WHILE MAXIMIZING BENEFITS FOR OLDER ADULTS WITH ADRD. WITHOUT ADDITIONAL EVIDENCE, PROVIDERS MAY CONTINUE TO EITHER OVER- OR UNDERTREAT HTN IN PEOPLE WITH ADRD. THE OVERALL OBJECTIVE OF THIS PROPOSAL IS TO COMPARE THE SAFETY AND EFFECTIVENESS OF DIFFERENT HTN TREATMENT STRATEGIES FOR OLDER ADULTS WITH ADRD RESIDING IN NH. THIS PROPOSAL HAS THREE AIMS: (1) DESCRIBE HTN TREATMENT STRATEGIES AMONG NH RESIDENTS WITH ADRD, INCLUDING BP MEASURES AND CHANGES TO MEDICATIONS; 2) ESTIMATE THE BENEFITS AND HARMS OF AN INTENSIVE HTN TREATMENT STRATEGY FOR NH RESIDENTS WITH ADRD; AND (3) IDENTIFY OPTIMAL HTN TREATMENT STRATEGIES FOR CLINICALLY RELEVANT SUBGROUPS OF NH RESIDENTS. OUR CENTRAL HYPOTHESIS IS INTENSIVE HTN TREATMENT PROVIDES LIMITED BENEFITS AND INCREASED HARMS FOR MANY NH RESIDENTS WITH ADRD, YET SELECT SUBGROUPS CAN STILL DERIVE BENEFITS. OUR RIGOROUS PHARMACOEPIDEMIOLOGIC STUDIES WILL COMBINE NOVEL NH RESIDENT ELECTRONIC HEALTH RECORD (EHR) DATA FROM UP TO 10,000 NHS LINKED WITH SEVERAL OTHER RICH DATA SOURCES INCLUDING: (1) MEDICARE PART A AND PART B CLAIMS DATA; (2) MEDICARE PART D DRUG CLAIMS; (3) MINIMUM DATA SET VERSION 3.0 CLINICAL ASSESSMENTS; (4) THE CERTIFICATION AND SURVEY PROVIDER ENHANCED REPORTS AND LTCFOCUS DATABASES; AND (5) SEVERAL OTHER DATABASES, INCLUDING U.S. CENSUS DATA. STUDIES WILL LEVERAGE INNOVATIVE CAUSAL INFERENCE METHODS INCLUDING DYNAMIC TREATMENT STRATEGIES, G-COMPUTATION, AND TARGET TRIAL EMULATION. THIS PROJECT WILL PRODUCE CRITICAL, GENERALIZABLE EVIDENCE TO OPTIMIZE HTN TREATMENT STRATEGIES FOR OLDER ADULTS WITH AND WITHOUT ADRD AND INFORM DEPRESCRIBING INTERVENTIONS. THIS RESEARCH PROJECT WILL ADDRESS STRATEGIC GOALS C AND D OF THE NATIONAL INSTITUTE ON AGING AND NOT-AG-21-045: “OPPORTUNITIES FOR RESEARCH IN EPIDEMIOLOGY OF AD/ADRD AND COGNITIVE RESILIENCE.”

CAN NEUROMUSCULAR TRAINING ALTER MOVEMENT PATTERNS?

CONTROL NO. 3387-2025 UNIVERSITY OF DELAWARE DE-FOA-0003387 VISION OPEN 2024 PROJECT TITLE: RECYCLING OF POLYOLEFINS VIA NOVEL ELECTROTHERMOCHEMICAL PROCESSING NEW AWARD UNIVERSITY OF DELAWARE AIMS TO CONVERT SINGLE-USE PLASTICS AT LOW TEMPERATURES AND SIGNIFICANTLY DECREASED REACTION TIMES. THE TEAM WILL ELECTRIFY THE HEATING PROCESS TO BREAKDOWN PLASTICS INTO SMALLER COMPONENTS THAT CAN BE REUSED WITH GREATER THAN 90% YIELD. THIS TECHNOLOGY WILL ALLOW RECYCLING OF SINGLE-USE PLASTICS, THEREBY REMOVING CARBON FROM THE ENVIRONMENT AND ELIMINATING THE NEED TO FOSSIL FUEL FEEDSTOCKS.

ADVERSE NEUROGENIC ACTIONS OF DIETARY SALT

COATS: COLLAGEN-MIMETIC PEPTIDE AND THERAPEUTIC GENE-MODIFIED COLLAGENS FOR CELL-MEDIATED HEALING OF DIABETIC FOOT ULCERS - PROJECT SUMMARY – DIABETIC FOOT ULCERS (DFU) ARE AN ENORMOUSLY COSTLY WORLDWIDE HEALTH CONCERN. THEY CAUSE NEARLY 80,000 LOWER LEG AMPUTATIONS ANNUALLY IN THE U.S. ALONE AND ARE ASSOCIATED WITH SIGNIFICANTLY INCREASED LIKELIHOOD OF DEATH. STRATEGIES TO IMPROVE THEIR HEALING HAVE BEEN A SUBJECT OF INTENSE STUDY FOR DECADES, YET MYRIAD CELLULAR AND PATHOPHYSIOLOGICAL ABNORMALITIES CONTINUE TO SEVERELY LIMIT EFFICACY OF STANDARD THERAPIES. PROMISING THERAPEUTIC ALTERNATIVES INCLUDE THE APPLICATION OF CELLULAR SCAFFOLDS, TOPICAL GROWTH FACTORS (ESPECIALLY PLATELET-DERIVED GROWTH FACTOR), OR COMBINATION WOUND DRESSINGS. HOWEVER, THE INCIDENCE OF COMPLETE CLOSURE REMAINS STRIKINGLY LOW AND GROWTH FACTOR DELIVERY STRATEGIES LARGELY FAIL OWING TO THEIR INSTABILITY IN THE INFLAMMATORY, MMP-RICH ENVIRONMENT OF THE CHRONIC WOUND. NEW STRATEGIES THAT CAN NORMALIZE THIS PROTEOLYTIC AND INFLAMMATORY ENVIRONMENT, BY STIMULATING LOCAL PRODUCTION OF THERAPEUTIC PROTEINS BY FIBROBLASTS AND MACROPHAGES, WOULD THUS OFFER A PROVOCATIVE APPROACH TO IMPROVE CLINICAL OUTCOMES. WE HAVE RECENTLY DEMONSTRATED THAT PROTEASE ACTIVITY IN THE WOUND BED CAN BE HARNESSED TO STIMULATE LOCALIZED GROWTH FACTOR GENE DELIVERY AND PROVIDE TAILORABLE EXPRESSION OF GROWTH FACTORS OVER MULTIWEEK TIMEFRAMES. WE INTRODUCE COLLAGEN MIMETIC PEPTIDE (CMP) AND THERAPEUTIC GENE-MODIFIED COLLAGENS (COATS) AS A PLATFORM FOR (I) ROBUST RETENTION OF GROWTH FACTOR-ENCODING POLYPLEXES IN COLLAGEN- CONTAINING WOUND DRESSINGS AND (II) LOCALIZED, CELL-INITIATED GENE DELIVERY DURING COLLAGEN REMODELING. BECAUSE COATS INTEGRATE DNA POLYPLEXES DIRECTLY INTO COLLAGEN FIBRILS, OUR APPROACHES HAVE BEEN SHOWN TO SIGNIFICANTLY IMPROVE IN VIVO WOUND REPAIR AT CONCENTRATIONS OF GROWTH FACTORS ORDERS OF MAGNITUDE LOWER THAN THOSE IN CURRENTLY EMPLOYED TOPICAL THERAPIES. THESE OUTCOMES, COUPLED WITH RECENT ADVANCES IN THE TRANSLATION OF OTHER GENE THERAPIES, SUGGESTS THE HIGH POTENTIAL FOR CLINICAL IMPACT OF THE COATS PLATFORM. IN THE PROPOSED R01 PROGRAM, WE WILL APPLY COATS IN EXPERIMENTAL DFUS AND CELL-BASED ASSAYS TO UNDERSTAND THREE IMPORTANT ASPECTS OF ORCHESTRATING WOUND REPAIR, IN THE FOLLOWING THREE AIMS. IN AIM 1, WE WILL PROBE VARIATIONS IN CMP MODIFICATIONS THAT OPTIMIZE THE EXTENDED DELIVERY OF GENES (INITIALLY FOR PLATELET-DERIVED GROWTH FACTOR (PDGF)) IN A MURINE DIABETIC WOUND ENVIRONMENT. IN AIM 2, WE WILL COMPLEMENT THESE STUDIES WITH CELL-BASED INVESTIGATIONS THAT ELUCIDATE THE ROLE OF MMPS (SOLUBLE AND MEMBRANE-BOUND) IN REGULATING PDGF GENE DELIVERY BY COATS AND PDGF PROTEIN LIFETIME. IN AIM 3, WE WILL TEST HOW COATS-MEDIATED, SEQUENTIAL DELIVERY OF GENES FOR IMMUNOMODULATORY CYTOKINES (IL4 AND IL10) MODULATES MMP ACTIVITY IN DFUS. THESE APPROACHES WILL PROVIDE BOTH MECHANISTIC INSIGHTS FOR RESOLVING THE CHRONICITY OF DFUS, AND ALSO A NEW PLATFORM THAT COULD BE INTEGRATED INTO EXISTING WOUND-CARE STRATEGIES TO DRAMATICALLY IMPROVE CLINICAL OUTCOMES.

TAS::57 3600::TAS COHERENT PHOTONIC DEVICES FOR HIGH PERFORMANCE RF APPLICATIONS

CENTER FOR BIOMEDICAL RESEARCH EXCELLENCE IN MULTISCALE BIOMOLECULAR SENSING (MBS) - OVERALL PLAN PROJECT SUMMARY / ABSTRACT THE ABILITY TO SENSE AND RESPOND TO BIOLOGICAL SIGNALS STANDS AT THE FOREFRONT OF ALL ASPECTS OF HUMAN HEALTH AND DISEASE. NATURE HAS EVOLVED A HOST OF MECHANISMS TO SENSE CHANGES IN THE ENVIRONMENT RANGING IN SCALE FROM SMALL MOLECULE CHEMICAL CUES, TO PROTEIN-PROTEIN INTERACTIONS, TO LARGER PHYSICAL CHANGES IN ORGANS. SENSING AND MEASUREMENT OF THESE BIOCHEMICAL PROCESSES IN AND BETWEEN DISTINCT CELL TYPES IS CRITICAL TO UNDERSTANDING AND TREATING HUMAN DISEASES SUCH AS NEURODEGENERATIVE, CARDIOVASCULAR AND AUTOIMMUNE DISORDERS, AND CHRONIC PAIN. TO UNDERSTAND THESE DISEASES, STUDIES MUST REVEAL NOT ONLY THE CHEMICAL AND BIOCHEMICAL REACTIONS THAT ARE OCCURRING, BUT ALSO MUST RESOLVE THESE EVENTS IN TIME (RELATIVE TO OTHER BIOCHEMICAL EVENTS) AND SPACE (WHERE IN CELLS, TISSUES, AND ORGANS) AND BE ABLE TO SIMULTANEOUSLY DETECT MULTIPLE UNIQUE PROCESSES. THE CENTER OF BIOMEDICAL RESEARCH EXCELLENCE IN MULTISCALE BIOMOLECULAR SENSING WILL UNITE EXPERTS IN BIOLOGY, BIOCHEMISTRY, CHEMISTRY, SPECTROSCOPY, MATERIALS SCIENCE, AND BIOMEDICAL ENGINEERING TO DEVELOP NOVEL MECHANISMS AND TOOLS FOR SENSING OF BIOCHEMICAL AND BIOLOGICAL PROCESSES THAT WILL DIRECTLY IMPACT A WIDE RANGE OF HUMAN DISEASES. PROJECTS IN THIS COBRE WILL ENABLE SENSING ACROSS SIZE SCALES FROM MOLECULES TO ANIMALS. THIS COBRE WILL: AIM 1: ACCELERATE FUNDAMENTAL RESEARCH INVOLVING MULTI-SCALE SENSING BY SUPPORTING SYNERGISTIC AND MULTIDISCIPLINARY RESEARCH PROJECTS. AIM 2: ENABLE RESEARCH IN BIOLOGICAL SENSING BY ESTABLISHING THE MULTISCALE BIOMOLECULAR SENSING RESEARCH CORE. AIM 3: ESTABLISH OF A ROBUST ADVISORY COMMITTEE FOR CENTER OVERSIGHT. AIM 4: AMPLIFY FACULTY SUCCESS WITH MENTORING AND RETENTION PROGRAMS, RECRUITMENT, AND PILOT PROJECTS. COMPLETION OF THIS 5-YEAR PHASE I COBRE WILL ESTABLISH DELAWARE AS A LEADING RESEARCH HUB IN MULTISCALE BIOMOLECULAR SENSING. A STATE-OF-THE-ART RESEARCH CORE, INNOVATIVE MENTORING AND RETENTION TECHNIQUES, SUPPORTIVE LEADERSHIP, AND SYNERGISTIC COLLABORATIONS WILL CREATE A ROBUST AND HIGHLY COLLABORATIVE RESEARCH COMMUNITY. THIS CENTER, AND THE STUDIES THAT EMERGE FROM IT, WILL ILLUMINATE BIOCHEMICAL PATHWAYS, ENABLE DEEPER UNDERSTANDING OF HUMAN DISEASE STATES, AND RESULT IN THE DEVELOPMENT OF NOVEL TREATMENTS AND TECHNOLOGIES TO IMPROVE HUMAN HEALTH.

SHIP SUPPORT

THE GUIDING PRINCIPLES OF THE DELAWARE SPACE GRANT COLLEGE (DESGC) PROGRAM ARE AS FOLLOWS: REASON FOR DESGC'S EXISTENCE: TO SERVE THE PEOPLE OF THE S

COBRE ON MEMBRANE PROTEIN PRODUCTION AND CHARACTERIZATION

SUPPORTING TEACHERS TO TEACH MATHEMATICS THROUGH PROBLEM POSING

SUSTAINABLE MATERIAL AND PROCESS DEVELOPMENT FOR LARGE OFF-SHORE WIND BLADE SPAR CAPS

AWARD TYPE: PROJECT GRANT; ACTIVITIES TO BE PERFORMED: PROVIDE HIGH QUALITY SUPPORT AND TECHNICAL ASSISTANCE WITH PANDEMIC RELIEF PROGRAMS AND RECOVERY SERVICES TO SMALL BUSINESSES.; DELIVERABLES: GRANTEES WILL PROVIDE REPORTS ON ACTIVITIES AND PROGRESS TOWARD STATED GOALS TO SBA ON A QUARTERLY BASIS.; EXPECTED OUTCOMES: INCREASE AWARENESS OF AND PARTICIPATION IN PROGRAMS OF THE U.S SMALL BUSINESS ADMINISTRATION AND OTHER GOVERNMENT AGENCIES.; INTENDED BENEFICIARIES: SMALL BUSINESSES AND ENTREPRENEURS THAT FALL INTO A HISTORICALLY UNDERSERVED CATEGORY, INCLUDING MINORITY ENTREPRENEURS (BLACK, INDIGENOUS, AND PEOPLE OF COLOR), ENTREPRENEURS WITH DISABILITIES, LGBTQ ENTREPRENEURS, RURAL ENTREPRENEURS; VETERANS AND MILITARY ENTREPRENEURS (INCLUDING SPOUSES), WOMEN ENTREPRENEURS, INNOVATIVE STARTUPS, MICRO BUSINESSES, AND SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESSES; SUBRECIPIENT ACTIVITIES: GRANTEES (HUBS) AND THEIR CONTRACTORS (SPOKES) WILL PROVIDE HIGH QUALITY SUPPORT AND TECHNICAL ASSISTANCE WITH PANDEMIC RELIEF PROGRAMS AND RECOVERY SERVICES TO SMALL BUSINESSES. THIS SUPPORT TAKES THE FORM OF 1:1 COUNSELING AND GROUP TRAININGS.

UNIVERSITY OF DELAWARE DE-FOA-0002459, OPEN 2021 NEW AWARD CONTROL NO. 2459-2892 PROJECT TITLE: EFFICIENT MANUFACTURING OF LIGHTWEIGHT COMPOSITE ARCHITECTED STRUCTURES FOR TRANSPORTATION VEHICLES

IMANAGE-SEXUAL WELLNESS: DEVELOPMENT OF A SYMPTOM-MONITORING/SELF-MANAGEMENT PROGRAM TO ENHANCE SEXUAL WELLNESS AFTER SCI AND TBI

DOES A SUPERMARKET IMPROVE THE DIET & FOOD ENVIRONMENTOF LOW-INCOME RESIDENTS

CYBERCORPS SCHOLARSHIP FOR SERVICE: DEFENDING CYBERSPACE THROUGH ACTIVE LEARNING -THE UDARE CYBER SCHOLARSHIPS FOR SERVICE (SFS) PROGRAM AT THE UNIVERSITY OF DELAWARE (UD) WILL ADVANCE CYBERSECURITY EDUCATION AND CULTIVATE A SKILLED WORKFORCE BY PREPARING HIGHLY QUALIFIED CYBERSECURITY PROFESSIONALS FOR SERVICE IN CRUCIAL ROLES ACROSS FEDERAL, STATE, LOCAL, AND TRIBAL SECURITY SECTORS. THIS SFS PROJECT WILL PREPARE TWENTY UNDERGRADUATE AND MASTER'S STUDENTS FROM UD?S BROAD CYBERSECURITY DEGREE PROGRAMS, EMPLOYING A MULTIFACETED APPROACH TO PROFESSIONAL DEVELOPMENT. SFS SCHOLARS WILL BE IMMERSED IN RIGOROUS ACADEMIC TRAINING AND PRACTICAL, HANDS-ON EXPERIENCES THROUGH RESEARCH, DIVERSE ENRICHMENT ACTIVITIES, AND INTERNSHIPS. FURTHERMORE, THE UDARE PROGRAM WILL FOSTER A DIVERSE AND GLOBALLY COMPETITIVE STEM WORKFORCE BY ACTIVELY RECRUITING AND INVOLVING MEMBERS OF UNDERREPRESENTED GROUPS, INCLUDING WOMEN, INDIVIDUALS WITH DISABILITIES, AND MINORITIES. THIS COMPREHENSIVE TRAINING MODEL ADDRESSES A CRITICAL NATIONAL NEED FOR SKILLED CYBERSECURITY PROFESSIONALS, CONTRIBUTING TO SAFEGUARDING U.S. CYBERSPACE AGAINST VARIOUS THREATS. IN ADDITION, THE PROJECT ENHANCES PUBLIC CYBERSECURITY LITERACY, CONTRIBUTING SIGNIFICANTLY TO SOCIETAL WELL-BEING AND NATIONAL SECURITY. THE UDARE PROGRAM IS DESIGNED TO ADVANCE BOTH THE THEORETICAL AND PRACTICAL ASPECTS OF CYBERSECURITY. THE PROGRAM WILL PROVIDE SCHOLARSHIPS TO STUDENTS FROM UD?S UNDERGRADUATE CYBERSECURITY ENGINEERING AND THE GRADUATE CYBERSECURITY DEGREE PROGRAMS. THESE STUDENTS ARE GUIDED BY TWO FACULTY ADVISORS EACH, ENSURING A WELL-ROUNDED AND DIVERSE PERSPECTIVE IN THEIR FIELD OF STUDY. THE CURRICULUM COVERS VARIOUS CONCENTRATIONS WITHIN CYBERSECURITY, INCLUDING SECURE SOFTWARE, SECURE SYSTEMS, SECURITY ANALYTICS, AND SECURITY MANAGEMENT, PROVIDING A COMPREHENSIVE KNOWLEDGE BASE. A KEY COMPONENT OF THE UDARE SFS PROGRAM IS STUDENTS' ENGAGEMENT IN CUTTING-EDGE RESEARCH, DOCUMENTED THROUGH THESIS OR SENIOR PROJECTS, AND THEIR PARTICIPATION IN CYBERSECURITY-FOCUSED CONFERENCES AND WORKSHOPS. THE PROGRAM ALSO INCLUDES ENRICHMENT ACTIVITIES LIKE THE CYBERSECURITY SCHOLARS PROGRAM, DISTINGUISHED LECTURE SERIES, AND CAPTURE THE FLAG COMPETITIONS TO ENHANCE PRACTICAL SKILLS AND INDUSTRY READINESS. A SPECIALIZED PROFESSIONAL DEVELOPMENT COURSE WILL PREPARE STUDENTS FOR INTERNSHIP EXPERIENCES AND EVENTUAL JOB PLACEMENTS WITHIN THE FEDERAL GOVERNMENT. FINALLY, AN INDEPENDENT EVALUATOR WILL ASSESS THE PROGRAM'S EFFECTIVENESS AND IMPACT, ENSURING CONTINUOUS IMPROVEMENT AND ACCOUNTABILITY. THIS PROJECT IS SUPPORTED BY THE CYBERCORPS? SCHOLARSHIP FOR SERVICE (SFS) PROGRAM, WHICH FUNDS PROPOSALS ESTABLISHING OR CONTINUING SCHOLARSHIP PROGRAMS IN CYBERSECURITY AND ALIGNS WITH THE U.S. NATIONAL CYBER STRATEGY TO DEVELOP A SUPERIOR CYBERSECURITY WORKFORCE. FOLLOWING GRADUATION, SCHOLARSHIP RECIPIENTS ARE REQUIRED TO WORK IN CYBERSECURITY FOR A FEDERAL, STATE, LOCAL, OR TRIBAL GOVERNMENT ORGANIZATION FOR THE SAME DURATION AS THEIR SCHOLARSHIP SUPPORT. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

UNIVERSITY OF DELAWARE - NEW AWARD CONTROL NUMBER:1858-2651 ADVANCED ALKALINE MEMBRANE H2/AIR FUEL CELL SYSTEM WITH NOVEL TECHNIQUE FOR AIR CO2

RECOVERY OF SYMPTOMS, FUNCTION, TENDON STRUCTURE AND MECHANICAL PROPERTIES IN PATIENTS WITH ACHILLES TENDINOPATHY: A COMPARISON BETWEEN MEN AND WOMEN

HURRICAN SANDY MARSH RESOTRATION ACTIVITY ACROSS THE NORTHEAST SHORELINE

CENTER FOR DISABILITIES STUDIES (CDS)A UNIVERSITY CENTER FOR EXCELLENCE IN DEVELOPMENTAL DISABILITIES

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) -THE NATIONAL SCIENCE FOUNDATION (NSF) GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) IS A HIGHLY COMPETITIVE, FEDERAL FELLOWSHIP PROGRAM. GRFP HELPS ENSURE THE VITALITY AND DIVERSITY OF THE SCIENTIFIC AND ENGINEERING WORKFORCE OF THE UNITED STATES. THE PROGRAM RECOGNIZES AND SUPPORTS OUTSTANDING GRADUATE STUDENTS WHO ARE PURSUING RESEARCH-BASED MASTER'S AND DOCTORAL DEGREES IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) AND IN STEM EDUCATION. THE GRFP PROVIDES THREE YEARS OF FINANCIAL SUPPORT FOR THE GRADUATE EDUCATION OF INDIVIDUALS WHO HAVE DEMONSTRATED THEIR POTENTIAL FOR SIGNIFICANT RESEARCH ACHIEVEMENTS IN STEM AND STEM EDUCATION. THIS AWARD SUPPORTS THE NSF GRADUATE FELLOWS PURSUING GRADUATE EDUCATION AT THIS GRFP INSTITUTION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

NIH-FES-ASSISTED CYCLING TO IMPROVE FITNESS AND STRENGTH IN CHILDREN WITH CP

IGERT: SUSTAINABLE ENERGY FROM SOLAR HYDROGEN

UNRAVELING FIBROSIS WITH DYNAMIC MICROENVIRONMENTS AND MOLECULAR TOOLS

BOOSTING EFFICACY OF ORAL VACCINE CANDIDATES BY ENABLING SPORE DISPLAY OF NITRATED ANTIGENS - PROJECT SUMMARY MANY DISEASES COULD BE PREVENTED OR TREATED BY ENLISTING THE IMMUNE SYSTEM TO RECOGNIZE A SPECIFIC ANTIGEN. BACTERIAL DISEASES WARRANT HEIGHTENED ATTENTION AS MANY BACTERIAL PATHOGENS LACK EFFICACIOUS VACCINES AND EXHIBIT RISING RATES OF ANTIBIOTIC RESISTANCE. THESE PATHOGENS OFTEN FIND MANY WAYS OF EVADING IMMUNE SYSTEM DETECTION, INCLUDING VARYING THEIR MOST IMMUNOGENIC ANTIGENS. WHILE MANY VIRULENCE-RELATED PROTEINS CAN BE STRONGLY CONSERVED ACROSS PATHOGEN SEROTYPES, THEY OFTEN EXHIBIT WEAK IMMUNOGENICITY THAT IS INSUFFICIENT TO DRAW THE RESPONSE OF THE IMMUNE SYSTEM. IN THIS PROJECT, WE ASK: ARE THERE STRATEGIES TO SHINE A LIGHT ON LIVE BACTERIAL ANTIGENS FOR INCREASED RECOGNITION BY IMMUNE CELLS? FURTHERMORE, CAN WE COUPLE THESE STRATEGIES TO SHELF-STABLE DELIVERY VECTORS THAT ARE SIMPLE TO ADMINISTER TO PATIENTS ACROSS THE WORLD? WE PROPOSE A TRANSFORMATIONAL APPROACH TO EXPAND THE LIST OF CANDIDATE ANTIGENS FOR USE IN LIVE BACTERIAL VACCINE VECTORS BY TEACHING BACILLUS SUBTILIS TO PRODUCE AND HARNESS AN IMMUNOGENIC AMINO ACID. THIS AMINO ACID HAS BEEN DEMONSTRATED TO TERMINATE IMMUNE SELF-TOLERANCE WHEN SUBSTITUTED ON THE SURFACE OF AUTOLOGOUS PROTEINS IN MICE. SITE-SPECIFIC INTRODUCTION OF NITRATED RESIDUES WITHIN PROTEINS HAS RESULTED IN PRESENTATION OF A NEOEPITOPE THAT IS RECOGNIZED BY HELPER T CELLS FOR SUBSEQUENT ACTIVATION OF B CELLS THAT PRODUCE POLYCLONAL ANTIBODIES. IT STANDS TO REASON THAT THE IMMUNOGENICITY OF MANY WEAKLY IMMUNOGENIC FOREIGN ANTIGENS COULD BE INCREASED USING THIS STRATEGY, THOUGH THIS HAS NOT YET BEEN TESTED. ONE CHALLENGE IS THAT PRIOR STUDIES ALSO ESTABLISHED A CRITICAL BUT POORLY UNDERSTOOD ROLE OF THE MHC CLASS II LOCUS IN ENABLING IMMUNE RESPONSE TO NITRATED ANTIGENS. OUR PROJECT WILL INVESTIGATE THE POTENTIAL OF SPORE-DISPLAYED NITRATED ANTIGENS AS A TRANSFORMATIONAL VACCINATION PLATFORM FOR BACTERIAL DISEASE, WITH THE SHIGELLA INVASION PROTEIN ANTIGENS AS A MODEL SYSTEM. WE WILL FIRST PERFORM ANIMAL STUDIES WITH SHIGELLA ANTIGENS THAT ARE WEAKLY IMMUNOGENIC BUT STRONGLY CONSERVED ACROSS PATHOGEN SEROTYPES TO DETERMINE IF NITRATION CAN INCREASE THEIR IMMUNOGENICITY. TO BETTER UNDERSTAND WHERE NITRATED RESIDUES SHOULD BE PLACED FOR OPTIMAL RECOGNITION BY IMMUNE CELL MACHINERY, WE WILL DEVELOP A HIGH-THROUGHPUT MICROBIAL DISPLAY PLATFORM TO SCREEN MHC-II PREFERENCE TOWARDS UNNATURAL PEPTIDE LIGANDS. IN PARALLEL, WE WILL DEVELOP TOOLS TO ENABLE SITE-SPECIFIC INCORPORATION OF THE IMMUNOGENIC AMINO ACID WITHIN PROTEINS FUSED TO THE SPORE COAT OF B. SUBTILIS. RECOMBINANT SPORES OF THIS NON-PATHOGENIC ORGANISM CAN BE ORALLY ADMINISTERED AND MAINTAIN IMMUNIZATION EFFICACY AFTER EXPOSURE TO HARSH CONDITIONS. THE SPORE-BASED PLATFORM HAS PROMISE TO OVERCOME LIMITATIONS IN THE MANUFACTURE, TRANSPORT, AND ADMINISTRATION OF VACCINES; HOWEVER, THE PLATFORM HAS LOW IMMUNOGENICITY. OUR STRATEGY TO FORM NITRATED RESIDUES USING THIS PLATFORM COULD OVERCOME THAT LIMITATION. FROM THIS PROJECT, WE WILL GAIN INSIGHTS ABOUT THE REQUIREMENTS FOR ENHANCED IMMUNOGENICITY DUE TO NITRATION, AND WE WILL ADVANCE TOWARDS A PLATFORM TECHNOLOGY FOR IMMUNIZATION THAT FEATURES SHELF-STABILITY AND ORAL DELIVERY.

ALLIANCE FOR NANOHEALTH COMPETITIVE RESEARCH PROGRAM

DELAWARE SPACE GRANT CONSORTIUM

MECHANICAL INTEGRITY OF MEMORY SYSTEMS IN MILD COGNITIVE IMPAIRMENT